TYRA Tyra Biosciences, Inc. - Common Stock
$25.34
Price · Aug 24, 2026
Fundamentals as of Aug 4, 2026
52W Range
$12–$41
47% of range
Analyst Rating
BUY
22 analysts
Price Target
$51
+101% upside
P/E (TTM)
-12.6
ROE
-42.7%
Net Profit Margin
—
TYRA Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$25.34
Market Cap
$1.36B
P/E (TTM)
-12.6
EPS (TTM)
$-2.01
Revenue (TTM)
—
Div Yield
—
ROE
-42.7%
Debt/Equity
—
52W Range
$12 – $41
TYRA Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
Configure
10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
—
EPS
$-2.01
2021-12-31
→
2025-12-31
Free Cash Flow
$-95M
2021-12-31
→
2025-12-31
Margins
—
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
TYRA
Peer Median
P/E (TTM)
-12.6
—
P/B
5.3
2.7
Price / FCF
-14.3
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
TYRA
Peer Median
ROA
-37.1%
-43.1%
ROE
-42.7%
-49.0%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
TYRA
Peer Median
Current Ratio
14.7
9.0
Quick Ratio
4.3
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
TYRA
Peer Median
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
TYRA
Peer Median
TYRA Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
22 analysts
- Strong Buy 9 40.9%
- Buy 11 50.0%
- Hold 2 9.1%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
11 analysts · 2026-08-23
Median
$53.00
Mean
$50.82
← Below all targets
$25.34
Low
$39.00
High
$59.00
Median target
$53.00
+109.2%
Mean target
$50.82
+100.5%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.00%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| June 30, 2026 | $-0.69 | $-0.66 | -0.03% |
| March 31, 2026 | $-0.64 | $-0.60 | -0.04% |
| Dec. 31, 2025 | $-0.57 | $-0.54 | -0.03% |
| Sept. 30, 2025 | $-0.50 | $-0.51 | 0.01% |
| June 30, 2025 | $-0.47 | $-0.54 | 0.07% |
| March 31, 2025 | $-0.47 | $-0.50 | 0.03% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| TYRA | $1.41B | -13.1 | — | — | -42.7% | — |
| FBRX | $353M | -5.8 | 106.6% | -2555.2% | -86.9% | — |
| ZYME | $1.97B | -24.4 | 38.9% | -76.6% | -26.9% | — |
| XNCR | $1.10B | -12.3 | 13.7% | -73.2% | -14.0% | — |
| TRAX | — | — | — | — | — | — |
| BCAX | $953M | -6.7 | — | — | -33.0% | — |
| VIR | $841M | -1.9 | -7.6% | -638.9% | -51.1% | — |
| ABSI | $529M | -4.2 | -38.2% | -4113.7% | -63.5% | — |
| INBX | $1.15B | -8.7 | 550.0% | -10773.5% | -365.9% | — |
| NVAX | $1.09B | 2.6 | 64.7% | 39.2% | -977.1% | — |
| ORIC | $806M | -5.6 | — | — | -36.5% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 12
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| R&D Expense | $103M | $80M | $63M | $43M | $21M | $7M | |
| SG&A Expense | $30M | $24M | $17M | $16M | $6M | $2M | |
| Operating Expenses | $133M | $104M | $80M | $59M | $26M | $9M | |
| Operating Income | $-133M | $-104M | $-80M | $-59M | $-26M | $-9M | |
| Other Non-op | $13M | $18M | $11M | $4M | $-6.0K | $-39.0K | |
| Income Tax | $0 | $0 | $0 | $2.0K | $1.0K | $1.0K | |
| Net Income | $-120M | $-86M | $-69M | $-55M | $-26M | $-9M | |
| EPS (Basic) | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 | · | |
| EPS (Diluted) | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 | · | |
| Shares (Basic) | 59,602,328 | 57,217,746 | 42,704,876 | 41,883,904 | 13,780,546 | · | |
| Shares (Diluted) | 59,602,328 | 57,217,746 | 42,704,876 | 41,883,904 | 13,780,546 | · | |
| EBITDA | $-132M | $-104M | $-80M | $-59M | $-26M | · |
Balance Sheet 19
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $77M | $92M | $58M | $251M | $302M | $15M | |
| Prepaid Expense | $9M | $6M | $8M | $6M | $2M | $57.0K | |
| Current Assets | $265M | $347M | $212M | $257M | $304M | $15M | |
| PP&E (Net) | $1M | $2M | $2M | $1M | $1M | $297.0K | |
| PP&E (Gross) | · | $3M | $2M | $2M | $1M | $340.0K | |
| Accum. Depreciation | · | $1M | $807.0K | $461.0K | $169.0K | $43.0K | |
| Other Non-current Assets | $9M | $7M | $5M | $4M | $312.0K | $21.0K | |
| Total Assets | $283M | $364M | $226M | $266M | $307M | $16M | |
| Accounts Payable | $1M | $590.0K | $5M | $1M | $599.0K | $664.0K | |
| Current Liabilities | $18M | $15M | $15M | $6M | $4M | $2M | |
| Capital Leases | $5M | $6M | $6M | $2M | $981.0K | $0 | |
| Other Non-current Liabilities | $0 | $3.0K | $46.0K | $169.0K | $367.0K | $140.0K | |
| Total Liabilities | $23M | $20M | $22M | $8M | $5M | $2M | |
| Common Stock | $5.0K | $5.0K | $4.0K | $4.0K | $4.0K | $0 | |
| Retained Earnings | $-371M | $-251M | $-165M | $-96M | $-40M | $-14M | |
| AOCI | $393.0K | $770.0K | $381.0K | $0 | · | · | |
| Stockholders' Equity | $259M | $343M | $204M | $258M | $302M | $-14M | |
| Liabilities + Equity | $283M | $364M | $226M | $266M | $307M | $16M | |
| Shares Outstanding | 53,706,357 | 50,749,945 | 43,024,634 | 42,353,550 | 41,441,135 | 1,829,377 |
Cash Flow 9
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| D&A | $546.0K | $519.0K | $357.0K | $296.0K | $140.0K | $47.0K | |
| Stock-based Comp | $28M | $23M | $14M | $11M | $3M | $439.0K | |
| Other Non-cash | $-4M | $-7M | $5M | $-6M | $-478.0K | · | |
| Operating Cash Flow | $-95M | $-70M | $-50M | $-50M | $-24M | $-8M | |
| CapEx | $141.0K | $664.0K | $770.0K | $559.0K | $661.0K | $312.0K | |
| Investing Cash Flow | $72M | $-98M | $-145M | $-559.0K | $-645.0K | $-312.0K | |
| Financing Cash Flow | $8M | $202M | $2M | $632.0K | $311M | $23M | |
| Net Change in Cash | $-15M | $34M | $-193M | $-50M | $287M | $15M | |
| Free Cash Flow | $-95M | $-70M | $-51M | $-51M | $-24M | · |
Profitability 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| ROA | -37.1% | -29.3% | -28.1% | -19.3% | -16.3% | · | |
| ROE | -42.7% | -24.5% | -32.4% | -21.1% | -8.6% | · |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Current Ratio | 14.7 | 23.8 | 13.8 | 45.1 | 84.1 | · | |
| Quick Ratio | 4.3 | 6.3 | 3.8 | 44.1 | 83.6 | · |
Valuation (TTM) 8
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Net Income TTM | $-120M | $-86M | $-69M | $-55M | $-26M | · | |
| Market Cap | $1.41B | $705M | $596M | $322M | $583M | · | |
| P/E | -13.1 | -9.2 | -8.5 | -5.8 | -7.4 | · | |
| P/B | 5.4 | 2.1 | 2.9 | 1.2 | 1.9 | · | |
| P / Tangible Book | 5.4 | 2.1 | 2.9 | 1.2 | 1.9 | · | |
| P / Cash Flow | -14.8 | -10.1 | -11.9 | -6.4 | -24.6 | · | |
| P / FCF | -14.8 | -10.0 | -11.7 | -6.3 | -23.9 | · | |
| Earnings Yield | -7.6% | -10.9% | -11.7% | -17.4% | -13.6% | · |
Income Statement 11
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $39M | $33M | $28M | $25M | $24M | $25M | $22M | $23M | $18M | $17M | $21M | $19M | $12M | $10M | $10M | $11M | |
| SG&A Expense | $10M | $9M | $8M | $7M | $7M | $7M | $8M | $6M | $6M | $5M | $5M | $5M | $4M | $4M | $10M | $173.0K | |
| Operating Expenses | $49M | $42M | $37M | $33M | $31M | $32M | $30M | $29M | $24M | $22M | $26M | $24M | $16M | $14M | $15M | $14M | |
| Operating Income | $-49M | $-42M | $-37M | $-33M | $-31M | $-32M | $-30M | $-29M | $-24M | $-22M | $-26M | $-24M | $-16M | $-14M | $-15M | $-14M | |
| Other Non-op | $3M | $3M | $3M | $3M | $3M | $4M | $4M | $5M | $5M | $4M | $3M | $3M | $3M | $2M | $3M | $5.0K | |
| Net Income | $-46M | $-39M | $-34M | $-30M | $-28M | $-28M | $-26M | $-24M | $-19M | $-18M | $-23M | $-21M | $-13M | $-12M | $-13M | $-13M | |
| EPS (Basic) | $-0.69 | $-0.64 | $-0.57 | $-0.50 | $-0.47 | $-0.47 | $-0.43 | $-0.41 | $-0.32 | $-0.35 | $-0.54 | $-0.49 | $-0.31 | $-0.28 | $-0.30 | $-0.30 | |
| EPS (Diluted) | $-0.69 | $-0.64 | $-0.57 | $-0.50 | $-0.47 | $-0.47 | $-0.43 | $-0.41 | $-0.32 | $-0.35 | $-0.54 | $-0.49 | $-0.31 | $-0.28 | $-0.30 | $-0.30 | |
| Shares (Basic) | 65,991,171 | 61,746,050 | -118,955,750 | 59,670,757 | 59,550,771 | 59,336,550 | -112,554,397 | 58,874,497 | 58,668,712 | 52,228,934 | -85,147,300 | 42,868,340 | 42,589,213 | 42,394,623 | -83,442,210 | 41,997,195 | |
| Shares (Diluted) | 65,991,171 | 61,746,050 | -118,955,750 | 59,670,757 | 59,550,771 | 59,336,550 | -112,554,397 | 58,874,497 | 58,668,712 | 52,228,934 | -85,147,300 | 42,868,340 | 42,589,213 | 42,394,623 | -83,442,210 | 41,997,195 | |
| EBITDA | $-49M | $-42M | · | $-33M | $-31M | $-32M | · | $-29M | $-24M | $-22M | · | $-24M | $-16M | $-14M | · | $-14M |
Balance Sheet 19
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $74M | $85M | $77M | $62M | $98M | $101M | $92M | $104M | $99M | $254M | $58M | $216M | $232M | $242M | $251M | $263M | |
| Prepaid Expense | $13M | $11M | $9M | $6M | $6M | $6M | $6M | $5M | $5M | $8M | $8M | $9M | $8M | $5M | $6M | $4M | |
| Current Assets | $367M | $395M | $265M | $281M | $302M | $325M | $347M | $366M | $379M | $391M | $212M | $225M | $241M | $247M | $257M | $267M | |
| PP&E (Net) | $1M | $1M | $1M | $1M | $1M | $2M | $2M | $2M | $2M | $2M | $2M | $1M | $1M | $1M | $1M | $1M | |
| PP&E (Gross) | · | · | · | · | · | $3M | · | $3M | $3M | $3M | $2M | $2M | $2M | $2M | $2M | $2M | |
| Accum. Depreciation | · | · | · | · | · | $1M | · | $1M | $1M | $926.0K | $807.0K | $706.0K | $629.0K | $544.0K | $461.0K | $379.0K | |
| Other Non-current Assets | $9M | $10M | $9M | $13M | $11M | $10M | $7M | $6M | $5M | $5M | $5M | $5M | $866.0K | $4M | $4M | $4M | |
| Total Assets | $383M | $412M | $283M | $302M | $321M | $343M | $364M | $381M | $392M | $405M | $226M | $238M | $250M | $255M | $266M | $276M | |
| Accounts Payable | $2M | $4M | $1M | $2M | $2M | $2M | $590.0K | $1M | $2M | $3M | $5M | $2M | $1M | $1M | $1M | $3M | |
| Current Liabilities | $25M | $19M | $18M | $16M | $14M | $14M | $15M | $12M | $10M | $9M | $15M | $10M | $5M | $4M | $6M | $5M | |
| Capital Leases | $5M | $5M | $5M | $5M | $6M | $6M | $6M | $6M | $6M | $6M | $6M | $6M | $6M | $2M | $2M | $3M | |
| Other Non-current Liabilities | · | · | $0 | $0 | $0 | $0 | $3.0K | $11.0K | $20.0K | $29.0K | $46.0K | $77.0K | $108.0K | $139.0K | $169.0K | $226.0K | |
| Total Liabilities | $30M | $24M | $23M | $21M | $19M | $20M | $20M | $18M | $16M | $15M | $22M | $16M | $11M | $6M | $8M | $8M | |
| Common Stock | $6.0K | $6.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $4.0K | $4.0K | $4.0K | $4.0K | $4.0K | $4.0K | |
| Retained Earnings | $-456M | $-411M | $-371M | $-337M | $-308M | $-279M | $-251M | $-226M | $-202M | $-183M | $-165M | $-142M | $-121M | $-108M | $-96M | $-83M | |
| AOCI | $-580.0K | $107.0K | $393.0K | $442.0K | $436.0K | $688.0K | $770.0K | $2M | $-184.0K | $-6.0K | $381.0K | · | · | · | $0 | · | |
| Stockholders' Equity | $354M | $388M | $259M | $281M | $302M | $324M | $343M | $362M | $376M | $390M | $204M | $222M | $239M | $249M | $258M | $268M | |
| Liabilities + Equity | $383M | $412M | $283M | $302M | $321M | $343M | $364M | $381M | $392M | $405M | $226M | $238M | $250M | $255M | $266M | $276M | |
| Shares Outstanding | 59,662,877 | 59,469,687 | 53,706,357 | 53,318,198 | 53,233,494 | 53,089,957 | 50,749,945 | 52,871,825 | 52,736,458 | 52,474,533 | 43,024,634 | 42,928,884 | 42,817,233 | 42,535,374 | 42,353,550 | 42,136,971 |
Cash Flow 11
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $138.0K | $138.0K | $132.0K | $131.0K | $140.0K | $143.0K | $144.0K | $127.0K | $126.0K | $122.0K | $102.0K | $86.0K | $89.0K | $83.0K | $82.0K | $82.0K | |
| Stock-based Comp | $10M | $8M | $8M | $8M | $6M | $6M | $7M | $8M | $4M | $4M | $4M | $4M | $3M | $2M | $3M | $1M | |
| Other Non-cash | · | $-1M | · | · | · | $-4M | · | · | · | $-8M | · | · | · | $-483.0K | · | · | |
| Operating Cash Flow | $-31M | $-33M | $-24M | $-22M | $-24M | $-25M | $-20M | $-18M | $-10M | $-22M | $-14M | $-17M | $-10M | $-10M | $-12M | $-12M | |
| CapEx | $66.0K | $88.0K | $57.0K | $39.0K | $31.0K | $14.0K | $6.0K | $52.0K | $470.0K | $136.0K | $603.0K | $83.0K | $43.0K | $41.0K | $21.0K | $48.0K | |
| Investing Cash Flow | $18M | $-120M | $34M | $-15M | $21M | $32M | $7M | $22M | $-145M | $18M | $-144M | $-83.0K | $-43.0K | $-41.0K | $-21.0K | $-48.0K | |
| Stock Issued | $0 | $148M | · | · | $0 | $0 | · | · | · | · | · | · | · | · | · | · | |
| Net Stock Activity | · | $148M | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Financing Cash Flow | $2M | $160M | $5M | $647.0K | $583.0K | $2M | $706.0K | $743.0K | $373.0K | $200M | $324.0K | $467.0K | $370.0K | $376.0K | $3.0K | $364.0K | |
| Net Change in Cash | $-11M | $8M | $15M | $-37M | $-2M | $9M | $-12M | $4M | $-155M | $196M | $-158M | $-17M | $-9M | $-10M | $-12M | $-12M | |
| Free Cash Flow | · | $-33M | · | · | · | $-25M | · | · | · | $-22M | · | · | · | $-10M | · | · |
Profitability 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -12.9% | -10.4% | · | -8.8% | -7.9% | -7.5% | · | -7.8% | -5.8% | -5.5% | · | -8.2% | -4.9% | -4.3% | · | -4.2% | |
| ROE | -13.9% | -11.1% | · | -9.3% | -8.3% | -7.9% | · | -8.2% | -6.1% | -5.7% | · | -8.6% | -5.1% | -4.4% | · | -4.3% |
Liquidity & Solvency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 14.9 | 20.5 | · | 17.7 | 21.9 | 22.8 | · | 29.5 | 36.5 | 44.8 | · | 22.1 | 44.5 | 67.0 | · | 48.7 | |
| Quick Ratio | 3.0 | 4.4 | · | 3.9 | 7.2 | 7.1 | · | 8.4 | 9.6 | 29.2 | · | 21.3 | 43.0 | 65.6 | · | 48.0 |
Valuation (TTM) 8
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-143M | $-125M | · | $-110M | $-99M | $-89M | · | $-82M | $-71M | $-64M | · | $-59M | $-53M | $-54M | · | $-49M | |
| Market Cap | $1.91B | $2.28B | · | $746M | $509M | $494M | · | $1.24B | $843M | $861M | · | $591M | $729M | $684M | · | $370M | |
| P/E | -13.9 | -18.4 | · | -7.6 | -5.7 | -6.0 | · | -15.0 | -10.9 | -11.5 | · | -10.0 | -13.6 | -12.4 | · | -5.1 | |
| P/B | 5.4 | 5.9 | · | 2.7 | 1.7 | 1.5 | · | 3.4 | 2.2 | 2.2 | · | 2.7 | 3.1 | 2.7 | · | 1.4 | |
| P / Tangible Book | 5.4 | 5.9 | · | 2.7 | 1.7 | 1.5 | · | 3.4 | 2.2 | 2.2 | · | 2.7 | 3.1 | 2.7 | · | 1.4 | |
| P / Cash Flow | · | -69.9 | · | · | · | -19.4 | · | · | · | -39.1 | · | · | · | -69.4 | · | · | |
| P / FCF | · | -69.7 | · | · | · | -19.4 | · | · | · | -38.8 | · | · | · | -69.1 | · | · | |
| Earnings Yield | -7.2% | -5.4% | · | -13.2% | -17.4% | -16.7% | · | -6.7% | -9.2% | -8.7% | · | -10.0% | -7.3% | -8.1% | · | -19.8% |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Net Income | $-120M | $-86M | $-69M | $-55M | $-26M |
| Diluted EPS | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Current Ratio | 14.7 | 23.8 | 13.8 | 45.1 | 84.1 |
| Quick Ratio | 4.3 | 6.3 | 3.8 | 44.1 | 83.6 |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Free Cash Flow | $-95M | $-70M | $-51M | $-51M | $-24M |
My Metrics Your personal watchlist — selected rows from Full Fundamentals
📊
Pick the metrics that matter to you — click the ➕ next to any row in Full Fundamentals above.
Your selection is saved and follows you across all tickers.
Institutional owners (13F) 181 filers · $1.9B total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 33 (-24 vs prior Q) | 22 (+9 vs prior Q) | 67 (+15 vs prior Q) | 49 (+12 vs prior Q) | +6.1M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $389,624,083 | 12,198,625 | 20.33% | Shares |
| FMR LLC | $259,465,452 | 8,123,527 | 13.54% | Shares |
| Alta Partners Management Company, L.P. | $122,120,195 | 3,823,425 | 6.37% | Shares |
| Nextech Invest Ltd. | $113,501,505 | 3,553,585 | 5.92% | Shares |
| TCG Crossover Management, LLC | $103,772,421 | 3,248,980 | 5.42% | Shares |
| STATE STREET CORP | $68,363,354 | 2,140,368 | 3.57% | Shares |
| Commodore Capital LP | $59,887,500 | 1,875,000 | 3.13% | Shares |
| Paradigm Biocapital Advisors LP | $58,405,708 | 1,828,607 | 3.05% | Shares |
| Nextech Invest Ltd. | $56,376,468 | 4,055,861 | 2.94% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $48,179,797 | 1,508,447 | 2.51% | Shares |
| BVF INC/IL | $47,149,700 | 1,476,196 | 2.46% | Shares |
| VANGUARD GROUP INC | $36,938,081 | 1,405,024 | 1.93% | Shares |
| 5AM Venture Management, LLC | $32,875,778 | 1,029,298 | 1.72% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $32,482,980 | 1,017,000 | 1.70% | Shares |
| Hood River Capital Management LLC | $32,475,794 | 1,016,775 | 1.69% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $27,157,539 | 850,108 | 1.42% | Shares |
| Caligan Partners LP | $25,775,133 | 806,986 | 1.35% | Shares |
| Canaan Partners XI LLC | $23,955,000 | 750,000 | 1.25% | Shares |
| Siren, L.L.C. | $23,156,500 | 725,000 | 1.21% | Shares |
| Sio Capital Management, LLC | $22,208,361 | 695,315 | 1.16% | Shares |
| STEMPOINT CAPITAL LP | $20,210,163 | 632,754 | 1.05% | Shares |
| MARSHALL WACE, LLP | $18,625,268 | 583,133 | 0.97% | Shares |
| JENNISON ASSOCIATES LLC | $14,403,791 | 450,964 | 0.75% | Shares |
| TWO SIGMA INVESTMENTS, LP | $14,366,868 | 449,808 | 0.75% | Shares |
| GOLDMAN SACHS GROUP INC | $13,394,997 | 419,380 | 0.70% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12,872,427 | 403,019 | 0.67% | Shares |
| Defilade Capital Management, L.P. | $12,037,228 | 376,870 | 0.63% | Shares |
| Walleye Capital LLC | $11,111,862 | 347,898 | 0.58% | Shares |
| Woodline Partners LP | $10,222,078 | 320,040 | 0.53% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9,086,930 | 284,500 | 0.47% | Call option |
| BANK OF AMERICA CORP /DE/ | $8,955,529 | 280,386 | 0.47% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $8,550,306 | 267,699 | 0.45% | Shares |
| Qube Research & Technologies Ltd | $8,525,872 | 266,934 | 0.44% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $7,672,850 | 240,227 | 0.40% | Shares |
| ALGERT GLOBAL LLC | $7,637,493 | 239,120 | 0.40% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $7,180,272 | 224,805 | 0.37% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $6,691,686 | 209,508 | 0.35% | Shares |
| Affinity Asset Advisors, LLC | $6,388,383 | 200,012 | 0.33% | Shares |
| FRANKLIN RESOURCES INC | $6,143,340 | 192,340 | 0.32% | Shares |
| HighVista Strategies LLC | $5,901,681 | 184,774 | 0.31% | Shares |
| MILLENNIUM MANAGEMENT LLC | $5,674,844 | 177,672 | 0.30% | Shares |
| CITADEL ADVISORS LLC | $5,581,036 | 174,735 | 0.29% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $5,543,474 | 173,559 | 0.29% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $5,174,280 | 162,000 | 0.27% | Shares |
| Jump Financial, LLC | $5,014,580 | 157,000 | 0.26% | Shares |
| VICTORY CAPITAL MANAGEMENT INC | $4,873,565 | 152,585 | 0.25% | Shares |
| Ensign Peak Advisors, Inc | $4,680,392 | 146,537 | 0.24% | Shares |
| Trexquant Investment LP | $4,239,716 | 132,740 | 0.22% | Shares |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $3,931,495 | 123,090 | 0.21% | Shares |
| BARCLAYS PLC | $3,631,578 | 113,700 | 0.19% | Call option |
| ORBIMED ADVISORS LLC | $3,257,880 | 102,000 | 0.17% | Shares |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2,849,208 | 89,205 | 0.15% | Shares |
| JANUS HENDERSON GROUP PLC | $2,711,816 | 70,814 | 0.14% | Shares |
| OPPENHEIMER & CO INC | $2,676,029 | 83,783 | 0.14% | Shares |
| XTX Topco Ltd | $2,597,361 | 81,320 | 0.14% | Shares |
| Kalehua Capital Management LLC | $2,378,412 | 74,465 | 0.12% | Shares |
| RAYMOND JAMES FINANCIAL INC | $2,177,094 | 68,162 | 0.11% | Shares |
| SEI INVESTMENTS CO | $2,127,428 | 66,607 | 0.11% | Shares |
| Squarepoint Ops LLC | $2,037,932 | 63,805 | 0.11% | Shares |
| Fisher Asset Management, LLC | $1,923,745 | 60,230 | 0.10% | Shares |
| ALPS ADVISORS INC | $1,921,478 | 60,159 | 0.10% | Shares |
| CITIGROUP INC | $1,921,383 | 60,156 | 0.10% | Shares |
| ALLIANCEBERNSTEIN L.P. | $1,854,486 | 48,420 | 0.10% | Shares |
| AXA Investment Managers S.A. | $1,801,758 | 128,789 | 0.09% | Shares |
| RHUMBLINE ADVISERS | $1,662,114 | 52,039 | 0.09% | Shares |
| TD Asset Management Inc | $1,597,000 | 50,000 | 0.08% | Shares |
| Arkadios Wealth Advisors | $1,575,792 | 49,336 | 0.08% | Shares |
| TWO SIGMA ADVISERS, LP | $1,548,481 | 58,900 | 0.08% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $1,491,502 | 46,697 | 0.08% | Shares |
| JANE STREET GROUP, LLC | $1,437,300 | 45,000 | 0.08% | Put option |
| Susquehanna Portfolio Strategies, LLC | $1,433,403 | 44,878 | 0.07% | Shares |
| Swiss National Bank | $1,427,718 | 44,700 | 0.07% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1,415,804 | 44,327 | 0.07% | Shares |
| ExodusPoint Capital Management, LP | $1,310,370 | 41,026 | 0.07% | Shares |
| Rafferty Asset Management, LLC | $1,236,142 | 38,702 | 0.06% | Shares |
| Bank of New York Mellon Corp | $1,224,612 | 38,341 | 0.06% | Shares |
| Verdad Advisers, LP | $1,149,936 | 36,003 | 0.06% | Shares |
| WELLS FARGO & COMPANY/MN | $1,071,938 | 33,561 | 0.06% | Shares |
| Sofinnova Investments, Inc. | $1,030,608 | 32,267 | 0.05% | Shares |
| Engineers Gate Manager LP | $1,020,739 | 31,958 | 0.05% | Shares |
| BlackRock, Inc. | $841,236 | 26,338 | 0.04% | Shares |
| PDT Partners, LLC | $820,347 | 25,684 | 0.04% | Shares |
| MILLENNIUM MANAGEMENT LLC | $798,500 | 25,000 | 0.04% | Call option |
| STRS OHIO | $705,874 | 22,100 | 0.04% | Shares |
| MetLife Investment Management, LLC | $693,833 | 21,723 | 0.04% | Shares |
| LMR Partners LLP | $675,563 | 21,151 | 0.04% | Shares |
| Auour Investments LLC | $671,379 | 21,020 | 0.04% | Shares |
| Vanguard Global Advisers, LLC | $643,719 | 20,154 | 0.03% | Shares |
| Elmind Capital, LP | $638,800 | 20,000 | 0.03% | Shares |
| PROFUND ADVISORS LLC | $625,641 | 19,588 | 0.03% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $594,467 | 18,612 | 0.03% | Shares |
| Cubist Systematic Strategies, LLC | $549,946 | 39,310 | 0.03% | Shares |
| AMERIPRISE FINANCIAL INC | $540,425 | 16,920 | 0.03% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $538,764 | 16,868 | 0.03% | Shares |
| WINTON GROUP Ltd | $536,592 | 16,800 | 0.03% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $494,399 | 15,479 | 0.03% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $479,100 | 15,000 | 0.03% | Put option |
| Invesco Ltd. | $463,897 | 14,524 | 0.02% | Shares |
| FOX RUN MANAGEMENT, L.L.C. | $461,533 | 14,450 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $412,761 | 12,923 | 0.02% | Shares |
Company insiders 24 insiders · 12 officers · 12 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Todd Harris | President and CEO | May 5, 2026 A | 1,437,631 | 0 | 0 | $0 |
| Alan Fuhrman | Chief Financial Officer | May 5, 2026 A | 36,164 | 0 | 0 | $0 |
| Esther Van Den Boom | Chief Financial Officer | Sept. 15, 2022 A | 121,897 | 0 | 0 | $0 |
| Bhavesh Ashar | Chief Operating Officer | May 5, 2026 A | 15,013 | 0 | 0 | $0 |
| Yuliya Rueb | Vice President, Finance (PAO) | May 5, 2026 A | 43,354 | 0 | 0 | $0 |
| Douglas J Warner | Chief Medical Officer | May 5, 2026 A | 25,000 | 0 | 0 | $0 |
| Daniel Bensen | Chief Discovery Officer | Feb. 12, 2026 S | 146,981 | 0 | 11 | $-4,811,405 |
| Hiroomi Tada | Chief Medical Officer | March 15, 2024 A | 86,435 | 0 | 0 | $0 |
| Patel Piyush R. | Chief Development Officer | Feb. 21, 2023 G | 73,794 | 0 | 0 | $0 |
| Robert L. Hudkins | Chief Technology Officer | Sept. 15, 2022 A | 273,576 | 0 | 0 | $0 |
| Ronald V. Swanson | Chief Scientific Officer | Sept. 6, 2022 A | 273,254 | 0 | 0 | $0 |
| Ali D. Fawaz | General Counsel and Secretary | May 16, 2022 A | — | 0 | 0 | $0 |
| Habib J Dable | Director | April 16, 2026 A | — | 0 | 0 | $0 |
| Gilla Kaplan | Director | March 26, 2026 M | 28,231 | 0 | 1 | $-528,486 |
| Robert J More | Director | Dec. 19, 2025 S | 3,823,425 | 0 | 2 | $-5,249,138 |
| Stephen Michael Rothenberg | Director | May 29, 2025 A | — | 0 | 0 | $0 |
| Rehan Verjee | Director | May 29, 2025 A | — | 0 | 0 | $0 |
| Susan Moran | Director | May 29, 2025 A | — | 0 | 0 | $0 |
| Nina S Kjellson | Director | Feb. 5, 2025 S | 443,885 | 0 | 0 | $0 |
| Adele M. Gulfo | Director | Jan. 29, 2025 A | — | 0 | 0 | $0 |
| Siddarth Subramony | Director | May 29, 2024 A | — | 0 | 0 | $0 |
| Jake Simson | Director | May 29, 2024 A | — | 0 | 0 | $0 |
| Isan Chen | Director | May 31, 2023 A | 192,783 | 0 | 0 | $0 |
| Boxer Capital Management, LLC | — | Oct. 18, 2024 A | 4,448,359 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 5 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. ×7 filings | March 6, 2026 | 21.20% | Amendment | — | SEC |
| MVA Investors, LLC, Aaron I. Davis, Boxer Capital Management, LLC ×3 filings | Dec. 6, 2024 | — | Initial filing | — | SEC |
| Boxer Asset Management Inc, Joe Lewis | Oct. 15, 2024 | — | Initial filing | — | SEC |
| Boxer Capital, LLC, MVA Investors, LLC, Aaron I. Davis, Boxer Capital Management, LLC, Siddarth Subramony ×4 filings | Oct. 15, 2024 | — | Initial filing | — | SEC |
| Alta Partners NextGen Fund II, L.P., Alta Partners NextGen Fund II Management, LLC, Peter Hudson, Daniel Janney, Robert More | Sept. 27, 2021 | — | Initial filing | Passive investment | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 43 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| SBIO · ALPS ETF Trust | 1.15% | 55,509 NS | May 31, 2026 | N-PORT |
| BBC · ETFis Series Trust I | 1.14% | 12,196 NS | April 30, 2026 | N-PORT |
| CANC · Tema ETF Trust | 0.30% | 15,780 NS | May 31, 2026 | N-PORT |
| ESSC · Strategy Shares | 0.25% | 1,876 NS | April 30, 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0.25% | 37,514 NS | April 30, 2026 | N-PORT |
| VFMO · VANGUARD WELLINGTON FUND | 0.13% | 81,594 SH | Aug. 19, 2026 | Daily |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0.10% | 3,505 SH | Aug. 21, 2026 | Daily |
| BIB · ProShares Trust | 0.09% | 1,974 NS | May 31, 2026 | N-PORT |
| FFSM · FIDELITY COVINGTON TRUST | 0.09% | 33,120 NS | April 30, 2026 | N-PORT |
| IBB · iShares Trust | 0.08% | 330,973 SH | Aug. 21, 2026 | Daily |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0.07% | 39,429 SH | Aug. 19, 2026 | Daily |
| IWO · iShares Trust | 0.06% | 339,557 SH | Aug. 21, 2026 | Daily |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.04% | 211,804 SH | Aug. 19, 2026 | Daily |
| IWM · iShares Trust | 0.03% | 937,680 SH | Aug. 21, 2026 | Daily |
| RSSL · Global X Funds | 0.03% | 11,184 NS | April 30, 2026 | N-PORT |
| GSSC · Goldman Sachs ETF Trust | 0.02% | 7,291 NS | May 31, 2026 | N-PORT |
| RB · ProShares Trust | 0.02% | 8 NS | May 31, 2026 | N-PORT |
| ITWO · ProShares Trust | 0.02% | 1,219 NS | May 31, 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0.02% | 114,471 NS | May 31, 2026 | N-PORT |
| OMFS · Invesco Exchange-Traded Self-Indexe… | 0.02% | 1,805 SH | Aug. 21, 2026 | Daily |
| UWM · ProShares Trust | 0.01% | 954 NS | May 31, 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0.01% | 340,900 SH | Aug. 19, 2026 | Daily |
| VHT · VANGUARD WORLD FUND | 0.01% | 67,148 SH | Aug. 19, 2026 | Daily |
| URTY · ProShares Trust | 0.01% | 967 NS | May 31, 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0.01% | 6,122 NS | April 30, 2026 | N-PORT |
| ISCV · iShares Trust | 0.01% | 1,827 SH | Aug. 21, 2026 | Daily |
| ONEQ · Fidelity Commonwealth Trust | 0.01% | 18,052 NS | May 31, 2026 | N-PORT |
| ISCB · iShares Trust | 0.01% | 583 SH | Aug. 21, 2026 | Daily |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.00% | 1,002 NS | May 31, 2026 | N-PORT |
| ISCG · iShares Trust | 0.00% | 1,509 SH | Aug. 21, 2026 | Daily |
| HDG · ProShares Trust | 0.00% | 24 NS | May 31, 2026 | N-PORT |
| WSML · iShares Trust | 0.00% | 955 SH | Aug. 21, 2026 | Daily |
| DFAS · Dimensional ETF Trust | 0.00% | 12,741 NS | April 30, 2026 | N-PORT |
| ITOT · iShares Trust | 0.00% | 46,934 SH | Aug. 21, 2026 | Daily |
| SCHB · SCHWAB STRATEGIC TRUST | 0.00% | 13,115 NS | May 31, 2026 | N-PORT |
| IWV · iShares Trust | 0.00% | 6,620 SH | Aug. 21, 2026 | Daily |
| DCOR · Dimensional ETF Trust | 0.00% | 548 NS | April 30, 2026 | N-PORT |
| DFUS · Dimensional ETF Trust | 0.00% | 1,440 NS | April 30, 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0.00% | 682 NS | April 30, 2026 | N-PORT |
| AVSU · AMERICAN CENTURY ETF TRUST | 0.00% | 10 NS | May 31, 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 1,135,472 SH | Aug. 19, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 3,044 SH | Aug. 19, 2026 | Daily |
| SMMV · iShares Trust | — | 4,074 SH | Aug. 19, 2026 | Daily |