TYRA Tyra Biosciences, Inc. - Common Stock
NASDAQ · Biotechnology · View on SEC EDGAR ↗ 10-K/10-Q Aug 4, 2026
$21.32
· of 52w range
· above low
· to high
$13.3552w low
$40.6552w high
Market Cap (MRQ)
$1.27B
P/E
-10.6
EPS
$-2.01
your badges
52W Range
$13–$41
Analyst Rating
BUY
Price Target
$47
P/E
-10.6
ROE
-42.7%
Net Profit Margin
·
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TYRA Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$21.32
Market Cap (MRQ)
$1.27B
P/E
-10.6
EPS
$-2.01
ROE
-42.7%
52W Range
$13–$41
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10-Year Performance Revenue, net income, margins and EPS trends
EPS$-2.012021-12-31 → 2025-12-31
Free Cash Flow$-95M2021-12-31 → 2025-12-31
Valuation & Ratios
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
| Metric | 5Y trend | TYRA | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| P/E | -10.65Y avg ≈-8.8 | ≈-8.8 | · | · | |
| P/B (MRQ) | 3.65Y avg ≈2.7 | ≈2.7 | 4.8 | Fair value | |
| Price / FCF (TTM) | -11.65Y avg ≈-13.4 | ≈-13.4 | · | · | |
| Price / Cash Flow (TTM) | -11.65Y avg ≈-13.6 | ≈-13.6 | · | · | |
| Price / Tangible Book | 4.45Y avg ≈2.7 | ≈2.7 | · | · |
Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.
Profitability Gross, operating and net margins; ROE, ROA, ROIC
| Metric | 5Y trend | TYRA | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| ROA | -37.1%5Y avg ≈-26.0% | ≈-26.0% | -39.3% | Top tier | |
| ROE | -42.7%5Y avg ≈-25.9% | ≈-25.9% | -51.7% | Top tier |
Financial Health Debt, liquidity, solvency — balance sheet strength
| Metric | 5Y trend | TYRA | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| Current Ratio (MRQ) | 14.95Y avg ≈36.3 | ≈36.3 | 9.6 | Strong liquidity | |
| Quick Ratio | 4.35Y avg ≈28.4 | ≈28.4 | 5.6 | Low liquidity |
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
No data for this ratio group yet
Not enough fundamentals data to compute this ratio group yet.
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
No data for this ratio group yet
Not enough fundamentals data to compute this ratio group yet.
value · ≈ 5Y avg · industry median · verdict relative to median
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.73%
Next Report
Nov 03, 2026
| Period | Report | EPS Actual | EPS Est | Surprise |
|---|---|---|---|---|
| June 30, 2026 | Aug 12, 2026 | $-0.69 | $-0.66 | -4.1% |
| March 31, 2026 | $-0.64 | $-0.60 | -5.9% | |
| Dec. 31, 2025 | $-0.57 | $-0.54 | -5.8% | |
| Sept. 30, 2025 | $-0.50 | $-0.51 | 1.5% | |
| June 30, 2025 | $-0.47 | $-0.54 | 12.8% | |
| March 31, 2025 | $-0.47 | $-0.50 | 5.9% |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| R&D Expense | $103M | $80M | $63M | $43M | $21M | $7M | |
| SG&A Expense | $30M | $24M | $17M | $16M | $6M | $2M | |
| Operating Expenses | $133M | $104M | $80M | $59M | $26M | $9M | |
| Operating Income | $-133M | $-104M | $-80M | $-59M | $-26M | $-9M | |
| Other Non-op | $13M | $18M | $11M | $4M | $-6.0K | $-39.0K | |
| Income Tax | $0 | $0 | $0 | $2.0K | $1.0K | $1.0K | |
| Net Income | $-120M | $-86M | $-69M | $-55M | $-26M | $-9M | |
| EPS (Basic) | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 | · | |
| EPS (Diluted) | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 | · | |
| Shares (Basic) | 59,602,328 | 57,217,746 | 42,704,876 | 41,883,904 | 13,780,546 | · | |
| Shares (Diluted) | 59,602,328 | 57,217,746 | 42,704,876 | 41,883,904 | 13,780,546 | · | |
| EBITDA | $-132M | $-104M | $-80M | $-59M | $-26M | · |
Balance Sheet
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $77M | $92M | $58M | $251M | $302M | $15M | |
| Prepaid Expense | $9M | $6M | $8M | $6M | $2M | $57.0K | |
| Current Assets | $265M | $347M | $212M | $257M | $304M | $15M | |
| PP&E (Net) | $1M | $2M | $2M | $1M | $1M | $297.0K | |
| PP&E (Gross) | · | $3M | $2M | $2M | $1M | $340.0K | |
| Accum. Depreciation | · | $1M | $807.0K | $461.0K | $169.0K | $43.0K | |
| Other Non-current Assets | $9M | $7M | $5M | $4M | $312.0K | $21.0K | |
| Total Assets | $283M | $364M | $226M | $266M | $307M | $16M | |
| Accounts Payable | $1M | $590.0K | $5M | $1M | $599.0K | $664.0K | |
| Current Liabilities | $18M | $15M | $15M | $6M | $4M | $2M | |
| Capital Leases | $5M | $6M | $6M | $2M | $981.0K | $0 | |
| Other Non-current Liabilities | $0 | $3.0K | $46.0K | $169.0K | $367.0K | $140.0K | |
| Total Liabilities | $23M | $20M | $22M | $8M | $5M | $2M | |
| Common Stock | $5.0K | $5.0K | $4.0K | $4.0K | $4.0K | $0 | |
| Retained Earnings | $-371M | $-251M | $-165M | $-96M | $-40M | $-14M | |
| AOCI | $393.0K | $770.0K | $381.0K | $0 | · | · | |
| Stockholders' Equity | $259M | $343M | $204M | $258M | $302M | $-14M | |
| Liabilities + Equity | $283M | $364M | $226M | $266M | $307M | $16M | |
| Shares Outstanding | 53,706,357 | 50,749,945 | 43,024,634 | 42,353,550 | 41,441,135 | 1,829,377 |
Cash Flow
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| D&A | $546.0K | $519.0K | $357.0K | $296.0K | $140.0K | $47.0K | |
| Stock-based Comp | $28M | $23M | $14M | $11M | $3M | $439.0K | |
| Other Non-cash | $-4M | $-7M | $5M | $-6M | $-478.0K | · | |
| Operating Cash Flow | $-95M | $-70M | $-50M | $-50M | $-24M | $-8M | |
| CapEx | $141.0K | $664.0K | $770.0K | $559.0K | $661.0K | $312.0K | |
| Investing Cash Flow | $72M | $-98M | $-145M | $-559.0K | $-645.0K | $-312.0K | |
| Financing Cash Flow | $8M | $202M | $2M | $632.0K | $311M | $23M | |
| Net Change in Cash | $-15M | $34M | $-193M | $-50M | $287M | $15M | |
| Free Cash Flow | $-95M | $-70M | $-51M | $-51M | $-24M | · |
Profitability
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| ROA | -37.1% | -29.3% | -28.1% | -19.3% | -16.3% | · | |
| ROE | -42.7% | -24.5% | -32.4% | -21.1% | -8.6% | · |
Liquidity & Solvency
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Current Ratio | 14.7 | 23.8 | 13.8 | 45.1 | 84.1 | · | |
| Quick Ratio | 4.3 | 6.3 | 3.8 | 44.1 | 83.6 | · |
Per Share
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Book Value / Share | $4.83 | $6.76 | $4.75 | $6.09 | $7.28 | · | |
| Cash Flow / Share | $-1.60 | $-1.22 | $-1.17 | $-1.20 | · | · | |
| Cash / Share | $1.44 | $1.81 | $1.35 | $5.93 | $7.29 | · | |
| EPS (TTM) | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 | · |
Valuation (TTM)
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Net Income TTM | $-120M | $-86M | $-69M | $-55M | $-26M | · | |
| Market Cap | $1.41B | $705M | $596M | $322M | $583M | · | |
| P/E | -13.1 | -9.2 | -8.5 | -5.8 | -7.4 | · | |
| P/B | 5.4 | 2.1 | 2.9 | 1.2 | 1.9 | · | |
| P / Tangible Book | 5.4 | 2.1 | 2.9 | 1.2 | 1.9 | · | |
| P / Cash Flow | -14.8 | -10.1 | -11.9 | -6.4 | -24.6 | · | |
| P / FCF | -14.8 | -10.0 | -11.7 | -6.3 | -23.9 | · | |
| Earnings Yield | -7.6% | -10.9% | -11.7% | -17.4% | -13.6% | · |
Income Statement
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $39M | $33M | $28M | $25M | $24M | $25M | $22M | $23M | $18M | $17M | $21M | $19M | $12M | $10M | $10M | $11M | |
| SG&A Expense | $10M | $9M | $8M | $7M | $7M | $7M | $8M | $6M | $6M | $5M | $5M | $5M | $4M | $4M | $10M | $173.0K | |
| Operating Expenses | $49M | $42M | $37M | $33M | $31M | $32M | $30M | $29M | $24M | $22M | $26M | $24M | $16M | $14M | $15M | $14M | |
| Operating Income | $-49M | $-42M | $-37M | $-33M | $-31M | $-32M | $-30M | $-29M | $-24M | $-22M | $-26M | $-24M | $-16M | $-14M | $-15M | $-14M | |
| Other Non-op | $3M | $3M | $3M | $3M | $3M | $4M | $4M | $5M | $5M | $4M | $3M | $3M | $3M | $2M | $3M | $5.0K | |
| Net Income | $-46M | $-39M | $-34M | $-30M | $-28M | $-28M | $-26M | $-24M | $-19M | $-18M | $-23M | $-21M | $-13M | $-12M | $-13M | $-13M | |
| EPS (Basic) | $-0.69 | $-0.64 | $-0.57 | $-0.50 | $-0.47 | $-0.47 | $-0.43 | $-0.41 | $-0.32 | $-0.35 | $-0.54 | $-0.49 | $-0.31 | $-0.28 | $-0.30 | $-0.30 | |
| EPS (Diluted) | $-0.69 | $-0.64 | $-0.57 | $-0.50 | $-0.47 | $-0.47 | $-0.43 | $-0.41 | $-0.32 | $-0.35 | $-0.54 | $-0.49 | $-0.31 | $-0.28 | $-0.30 | $-0.30 | |
| Shares (Basic) | 65,991,171 | 61,746,050 | · | 59,670,757 | 59,550,771 | 59,336,550 | · | 58,874,497 | 58,668,712 | 52,228,934 | · | 42,868,340 | 42,589,213 | 42,394,623 | · | 41,997,195 | |
| Shares (Diluted) | 65,991,171 | 61,746,050 | · | 59,670,757 | 59,550,771 | 59,336,550 | · | 58,874,497 | 58,668,712 | 52,228,934 | · | 42,868,340 | 42,589,213 | 42,394,623 | · | 41,997,195 | |
| EBITDA | $-49M | $-42M | · | $-33M | $-31M | $-32M | · | $-29M | $-24M | $-22M | · | $-24M | $-16M | $-14M | · | $-14M |
Balance Sheet
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $74M | $85M | $77M | $62M | $98M | $101M | $92M | $104M | $99M | $254M | $58M | $216M | $232M | $242M | $251M | $263M | |
| Prepaid Expense | $13M | $11M | $9M | $6M | $6M | $6M | $6M | $5M | $5M | $8M | $8M | $9M | $8M | $5M | $6M | $4M | |
| Current Assets | $367M | $395M | $265M | $281M | $302M | $325M | $347M | $366M | $379M | $391M | $212M | $225M | $241M | $247M | $257M | $267M | |
| PP&E (Net) | $1M | $1M | $1M | $1M | $1M | $2M | $2M | $2M | $2M | $2M | $2M | $1M | $1M | $1M | $1M | $1M | |
| PP&E (Gross) | · | · | · | · | · | $3M | · | $3M | $3M | $3M | $2M | $2M | $2M | $2M | $2M | $2M | |
| Accum. Depreciation | · | · | · | · | · | $1M | · | $1M | $1M | $926.0K | $807.0K | $706.0K | $629.0K | $544.0K | $461.0K | $379.0K | |
| Other Non-current Assets | $9M | $10M | $9M | $13M | $11M | $10M | $7M | $6M | $5M | $5M | $5M | $5M | $866.0K | $4M | $4M | $4M | |
| Total Assets | $383M | $412M | $283M | $302M | $321M | $343M | $364M | $381M | $392M | $405M | $226M | $238M | $250M | $255M | $266M | $276M | |
| Accounts Payable | $2M | $4M | $1M | $2M | $2M | $2M | $590.0K | $1M | $2M | $3M | $5M | $2M | $1M | $1M | $1M | $3M | |
| Current Liabilities | $25M | $19M | $18M | $16M | $14M | $14M | $15M | $12M | $10M | $9M | $15M | $10M | $5M | $4M | $6M | $5M | |
| Capital Leases | $5M | $5M | $5M | $5M | $6M | $6M | $6M | $6M | $6M | $6M | $6M | $6M | $6M | $2M | $2M | $3M | |
| Other Non-current Liabilities | · | · | $0 | $0 | $0 | $0 | $3.0K | $11.0K | $20.0K | $29.0K | $46.0K | $77.0K | $108.0K | $139.0K | $169.0K | $226.0K | |
| Total Liabilities | $30M | $24M | $23M | $21M | $19M | $20M | $20M | $18M | $16M | $15M | $22M | $16M | $11M | $6M | $8M | $8M | |
| Common Stock | $6.0K | $6.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $4.0K | $4.0K | $4.0K | $4.0K | $4.0K | $4.0K | |
| Retained Earnings | $-456M | $-411M | $-371M | $-337M | $-308M | $-279M | $-251M | $-226M | $-202M | $-183M | $-165M | $-142M | $-121M | $-108M | $-96M | $-83M | |
| AOCI | $-580.0K | $107.0K | $393.0K | $442.0K | $436.0K | $688.0K | $770.0K | $2M | $-184.0K | $-6.0K | $381.0K | · | · | · | $0 | · | |
| Stockholders' Equity | $354M | $388M | $259M | $281M | $302M | $324M | $343M | $362M | $376M | $390M | $204M | $222M | $239M | $249M | $258M | $268M | |
| Liabilities + Equity | $383M | $412M | $283M | $302M | $321M | $343M | $364M | $381M | $392M | $405M | $226M | $238M | $250M | $255M | $266M | $276M | |
| Shares Outstanding | 59,662,877 | 59,469,687 | 53,706,357 | 53,318,198 | 53,233,494 | 53,089,957 | 50,749,945 | 52,871,825 | 52,736,458 | 52,474,533 | 43,024,634 | 42,928,884 | 42,817,233 | 42,535,374 | 42,353,550 | 42,136,971 |
Cash Flow
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $138.0K | $138.0K | $132.0K | $131.0K | $140.0K | $143.0K | $144.0K | $127.0K | $126.0K | $122.0K | $102.0K | $86.0K | $89.0K | $83.0K | $82.0K | $82.0K | |
| Stock-based Comp | $10M | $8M | $8M | $8M | $6M | $6M | $7M | $8M | $4M | $4M | $4M | $4M | $3M | $2M | $3M | $1M | |
| Other Non-cash | · | $-1M | · | · | · | $-4M | · | · | · | $-8M | · | · | · | $-483.0K | · | · | |
| Operating Cash Flow | $-31M | $-33M | $-24M | $-22M | $-24M | $-25M | $-20M | $-18M | $-10M | $-22M | $-14M | $-17M | $-10M | $-10M | $-12M | $-12M | |
| CapEx | $66.0K | $88.0K | $57.0K | $39.0K | $31.0K | $14.0K | $6.0K | $52.0K | $470.0K | $136.0K | $603.0K | $83.0K | $43.0K | $41.0K | $21.0K | $48.0K | |
| Investing Cash Flow | $18M | $-120M | $34M | $-15M | $21M | $32M | $7M | $22M | $-145M | $18M | $-144M | $-83.0K | $-43.0K | $-41.0K | $-21.0K | $-48.0K | |
| Stock Issued | $0 | $148M | · | · | $0 | $0 | · | · | · | · | · | · | · | · | · | · | |
| Net Stock Activity | · | $148M | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Financing Cash Flow | $2M | $160M | $5M | $647.0K | $583.0K | $2M | $706.0K | $743.0K | $373.0K | $200M | $324.0K | $467.0K | $370.0K | $376.0K | $3.0K | $364.0K | |
| Net Change in Cash | $-11M | $8M | $15M | $-37M | $-2M | $9M | $-12M | $4M | $-155M | $196M | $-158M | $-17M | $-9M | $-10M | $-12M | $-12M | |
| Free Cash Flow | · | $-33M | · | · | · | $-25M | · | · | · | $-22M | · | · | · | $-10M | · | · |
Profitability
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -12.9% | -10.4% | · | -8.8% | -7.9% | -7.5% | · | -7.8% | -5.8% | -5.5% | · | -8.2% | -4.9% | -4.3% | · | -4.2% | |
| ROE | -13.9% | -11.1% | · | -9.3% | -8.3% | -7.9% | · | -8.2% | -6.1% | -5.7% | · | -8.6% | -5.1% | -4.4% | · | -4.3% |
Liquidity & Solvency
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 14.9 | 20.5 | · | 17.7 | 21.9 | 22.8 | · | 29.5 | 36.5 | 44.8 | · | 22.1 | 44.5 | 67.0 | · | 48.7 | |
| Quick Ratio | 3.0 | 4.4 | · | 3.9 | 7.2 | 7.1 | · | 8.4 | 9.6 | 29.2 | · | 21.3 | 43.0 | 65.6 | · | 48.0 |
Per Share
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Book Value / Share | $5.93 | $6.52 | · | $5.26 | $5.68 | $6.09 | · | $6.85 | $7.13 | $7.43 | · | $5.18 | $5.57 | $5.85 | · | $6.35 | |
| Cash Flow / Share | · | $-0.53 | · | · | · | $-0.43 | · | · | · | $-0.42 | · | · | · | $-0.23 | · | · | |
| Cash / Share | $1.24 | $1.43 | · | $1.16 | $1.85 | $1.90 | · | $1.97 | $1.89 | $4.85 | · | $5.02 | $5.43 | $5.68 | · | $6.25 | |
| EPS (TTM) | $-2.40 | $-2.18 | · | $-1.87 | $-1.78 | $-1.63 | · | $-1.62 | $-1.70 | $-1.69 | · | $-1.38 | $-1.19 | $-1.24 | · | $0.70 |
Valuation (TTM)
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-149M | $-131M | · | $-112M | $-106M | $-96M | · | $-84M | $-81M | $-75M | · | $-59M | $-51M | $-52M | · | $-52M | |
| Market Cap | $1.91B | $2.28B | · | $746M | $509M | $494M | · | $1.24B | $843M | $861M | · | $591M | $729M | $684M | · | $370M | |
| P/E | -13.3 | -17.6 | · | -7.5 | -5.4 | -5.7 | · | -14.5 | -9.4 | -9.7 | · | -10.0 | -14.3 | -13.0 | · | 12.6 | |
| P/B | 5.4 | 5.9 | · | 2.7 | 1.7 | 1.5 | · | 3.4 | 2.2 | 2.2 | · | 2.7 | 3.1 | 2.7 | · | 1.4 | |
| P / Tangible Book | 5.4 | 5.9 | · | 2.7 | 1.7 | 1.5 | · | 3.4 | 2.2 | 2.2 | · | 2.7 | 3.1 | 2.7 | · | 1.4 | |
| P / Cash Flow | · | -69.9 | · | · | · | -19.4 | · | · | · | -39.1 | · | · | · | -69.4 | · | · | |
| Earnings Yield | -7.5% | -5.7% | · | -13.4% | -18.6% | -17.5% | · | -6.9% | -10.6% | -10.3% | · | -10.0% | -7.0% | -7.7% | · | 8.0% |
Most recent period on the left · null values shown as ·
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Net Income | $-120M | $-86M | $-69M | $-55M | $-26M |
| Diluted EPS | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 |
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Current Ratio | 14.7 | 23.8 | 13.8 | 45.1 | 84.1 |
| Quick Ratio | 4.3 | 6.3 | 3.8 | 44.1 | 83.6 |
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Free Cash Flow | $-95M | $-70M | $-51M | $-51M | $-24M |
Institutional owners (13F) 178 filers · $2.2B total · As of Sept. 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Holders
178
Value held
$2.2B
New positions
32
Exited positions
23
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 32 (-25 vs prior Q) | 23 (+10 vs prior Q) | 73 (+15 vs prior Q) | 45 (+13 vs prior Q) | +2.8M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $389,624,083 | 12,198,625 | 17.85% | Shares |
| FMR LLC | $284,921,184 | 8,920,513 | 13.05% | Shares |
| JANUS HENDERSON GROUP PLC | $148,867,244 | 3,890,589 | 6.82% | Shares |
| Alta Partners Management Company, L.P. | $122,120,195 | 3,823,425 | 5.59% | Shares |
| Nextech Invest Ltd. | $113,501,505 | 3,553,585 | 5.20% | Shares |
| TCG Crossover Management, LLC | $103,772,421 | 3,248,980 | 4.75% | Shares |
| BlackRock, Inc. | $96,841,186 | 3,031,972 | 4.44% | Shares |
| STATE STREET CORP | $68,363,354 | 2,140,368 | 3.13% | Shares |
| Commodore Capital LP | $59,887,500 | 1,875,000 | 2.74% | Shares |
| Paradigm Biocapital Advisors LP | $58,405,708 | 1,828,607 | 2.68% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $48,179,797 | 1,508,447 | 2.21% | Shares |
| BVF INC/IL | $47,149,700 | 1,476,196 | 2.16% | Shares |
| VANGUARD GROUP INC | $41,348,518 | 1,572,785 | 1.89% | Shares |
| 5AM Venture Management, LLC | $32,875,778 | 1,029,298 | 1.51% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $32,482,980 | 1,017,000 | 1.49% | Shares |
| Hood River Capital Management LLC | $32,475,794 | 1,016,775 | 1.49% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $31,010,333 | 970,734 | 1.42% | Shares |
| Caligan Partners LP | $25,775,133 | 806,986 | 1.18% | Shares |
| Siren, L.L.C. | $23,156,500 | 725,000 | 1.06% | Shares |
| Sio Capital Management, LLC | $22,208,361 | 695,315 | 1.02% | Shares |
| STEMPOINT CAPITAL LP | $20,210,163 | 632,754 | 0.93% | Shares |
| MARSHALL WACE, LLP | $18,625,268 | 583,133 | 0.85% | Shares |
| Canaan Partners XI LLC | $16,402,500 | 750,000 | 0.75% | Shares |
| GOLDMAN SACHS GROUP INC | $14,803,455 | 463,477 | 0.68% | Shares |
| JENNISON ASSOCIATES LLC | $14,403,791 | 450,964 | 0.66% | Shares |
| TWO SIGMA INVESTMENTS, LP | $14,366,868 | 449,808 | 0.66% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12,872,427 | 403,019 | 0.59% | Shares |
| Defilade Capital Management, L.P. | $12,037,228 | 376,870 | 0.55% | Shares |
| BANK OF AMERICA CORP /DE/ | $11,170,440 | 349,732 | 0.51% | Shares |
| Walleye Capital LLC | $11,111,862 | 347,898 | 0.51% | Shares |
| Woodline Partners LP | $10,222,078 | 320,040 | 0.47% | Shares |
| NORTHERN TRUST CORP | $9,904,084 | 310,084 | 0.45% | Shares |
| MORGAN STANLEY | $9,592,284 | 300,322 | 0.44% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9,086,930 | 284,500 | 0.42% | Call option |
| CITADEL ADVISORS LLC | $8,889,126 | 278,307 | 0.41% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $8,550,306 | 267,699 | 0.39% | Shares |
| Qube Research & Technologies Ltd | $8,525,872 | 266,934 | 0.39% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $7,672,850 | 240,227 | 0.35% | Shares |
| ALGERT GLOBAL LLC | $7,637,493 | 239,120 | 0.35% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $7,180,272 | 224,805 | 0.33% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $6,933,472 | 217,078 | 0.32% | Shares |
| Affinity Asset Advisors, LLC | $6,388,383 | 200,012 | 0.29% | Shares |
| FRANKLIN RESOURCES INC | $6,143,340 | 192,340 | 0.28% | Shares |
| HighVista Strategies LLC | $5,901,681 | 184,774 | 0.27% | Shares |
| RAYMOND JAMES FINANCIAL INC | $5,777,339 | 180,881 | 0.26% | Shares |
| JPMORGAN CHASE & CO | $5,743,677 | 178,263 | 0.26% | Shares |
| MILLENNIUM MANAGEMENT LLC | $5,674,844 | 177,672 | 0.26% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $5,543,474 | 173,559 | 0.25% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $5,174,280 | 162,000 | 0.24% | Shares |
| Jump Financial, LLC | $5,014,580 | 157,000 | 0.23% | Shares |
Activists & 5%+ owners 6 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| Peter Kolchinsky, RA Capital Healthcare Fund, L.P., RA Capital Management, L.P., Rajeev Shah | Sept. 17, 2026 | 19.90% | Amendment | · | SEC |
| RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. ×7 filings | March 6, 2026 | 21.20% | Amendment | · | SEC |
| MVA Investors, LLC, Aaron I. Davis, Boxer Capital Management, LLC ×3 filings | Dec. 6, 2024 | · | Initial filing | · | SEC |
| Boxer Capital, LLC, MVA Investors, LLC, Aaron I. Davis, Boxer Capital Management, LLC, Siddarth Subramony ×4 filings | Oct. 15, 2024 | · | Initial filing | · | SEC |
| Boxer Asset Management Inc, Joe Lewis | Oct. 15, 2024 | · | Initial filing | · | SEC |
| Alta Partners NextGen Fund II, L.P., Alta Partners NextGen Fund II Management, LLC, Peter Hudson, Daniel Janney, Robert More | Sept. 27, 2021 | · | Initial filing | Passive investment | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Company insiders 24 insiders · 12 officers · 12 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Todd Harris | President and CEO | Sept. 15, 2026 A | 1,438,495 | 0 | 0 | $0 |
| Alan Fuhrman | Chief Financial Officer | Sept. 15, 2026 A | 37,115 | 0 | 0 | $0 |
| Esther Van Den Boom | Chief Financial Officer | Sept. 15, 2022 A | 121,897 | 0 | 0 | $0 |
| Bhavesh Ashar | Chief Operating Officer | May 5, 2026 A | 15,013 | 0 | 0 | $0 |
| Yuliya Rueb | Vice President, Finance (PAO) | Sept. 15, 2026 A | 11,258 | 0 | 0 | $0 |
| Douglas J Warner | Chief Medical Officer | May 5, 2026 A | 25,000 | 0 | 0 | $0 |
| Daniel Bensen | Chief Discovery Officer | Feb. 12, 2026 S | 146,981 | 0 | 11 | $-4,811,405 |
| Hiroomi Tada | Chief Medical Officer | March 15, 2024 A | 86,435 | 0 | 0 | $0 |
| Patel Piyush R. | Chief Development Officer | Feb. 21, 2023 G | 73,794 | 0 | 0 | $0 |
| Robert L. Hudkins | Chief Technology Officer | Sept. 15, 2022 A | 273,576 | 0 | 0 | $0 |
| Ronald V. Swanson | Chief Scientific Officer | Sept. 6, 2022 A | 273,254 | 0 | 0 | $0 |
| Ali D. Fawaz | General Counsel and Secretary | May 16, 2022 A | · | 0 | 0 | $0 |
| Rehan Verjee | Director | Sept. 9, 2026 P | 972 | 1 | 0 | $20,004 |
| Stephen Michael Rothenberg | Director | May 28, 2026 A | · | 0 | 0 | $0 |
| Jake Simson | Director | May 28, 2026 A | · | 0 | 0 | $0 |
| Susan Moran | Director | May 28, 2026 A | · | 0 | 0 | $0 |
| Adele M. Gulfo | Director | May 28, 2026 A | · | 0 | 0 | $0 |
| Robert J More | Director | May 28, 2026 A | 3,823,425 | 0 | 2 | $-5,249,138 |
| Habib J Dable | Director | April 16, 2026 A | · | 0 | 0 | $0 |
| Gilla Kaplan | Director | March 26, 2026 M | 28,231 | 0 | 1 | $-528,486 |
| Nina S Kjellson | Director | Feb. 5, 2025 S | 443,885 | 0 | 0 | $0 |
| Siddarth Subramony | Director | May 29, 2024 A | · | 0 | 0 | $0 |
| Isan Chen | Director | May 31, 2023 A | 192,783 | 0 | 0 | $0 |
| Boxer Capital Management, LLC | · | Oct. 18, 2024 A | 4,448,359 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
ETF ownership Held by 32 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| BBC · ETFis Series Trust I | 0.79% | 11,516 NS | July 31, 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0.31% | 47,312 NS | July 31, 2026 | N-PORT |
| ESSC · Strategy Shares | 0.22% | 2,506 NS | July 31, 2026 | N-PORT |
| VFMO · VANGUARD WELLINGTON FUND | 0.13% | 81,594 SH | Aug. 19, 2026 | Daily |
| PWS · Pacer Funds Trust | 0.09% | 646 NS | July 31, 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0.08% | 4,480 SH | Oct. 23, 2026 | Daily |
| IBB · iShares Trust | 0.08% | 339,625 SH | Sept. 11, 2026 | Daily |
| FFSM · FIDELITY COVINGTON TRUST | 0.07% | 33,485 NS | July 31, 2026 | N-PORT |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0.07% | 39,429 SH | Aug. 19, 2026 | Daily |
| IWO · iShares Trust | 0.06% | 345,348 SH | Sept. 11, 2026 | Daily |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.04% | 211,804 SH | Aug. 19, 2026 | Daily |
| RSSL · Global X Funds | 0.04% | 17,612 NS | July 31, 2026 | N-PORT |
| IWM · iShares Trust | 0.03% | 944,901 SH | Sept. 11, 2026 | Daily |
| BBSC · J.P. Morgan Exchange-Traded Fund Tr… | 0.02% | 3,582 NS | July 31, 2026 | N-PORT |
| OMFS · Invesco Exchange-Traded Self-Indexe… | 0.01% | 1,799 SH | Oct. 23, 2026 | Daily |
| DFAS · Dimensional ETF Trust | 0.01% | 55,674 NS | July 31, 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0.01% | 10,602 NS | July 31, 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0.01% | 340,900 SH | Aug. 19, 2026 | Daily |
| VHT · VANGUARD WORLD FUND | 0.01% | 67,148 SH | Aug. 19, 2026 | Daily |
| ISCG · iShares Trust | 0.00% | 1,514 SH | Sept. 11, 2026 | Daily |
| WSML · iShares Trust | 0.00% | 965 SH | Sept. 11, 2026 | Daily |
| DCOR · Dimensional ETF Trust | 0.00% | 1,590 NS | July 31, 2026 | N-PORT |
| ITOT · iShares Trust | 0.00% | 46,806 SH | Sept. 11, 2026 | Daily |
| IWV · iShares Trust | 0.00% | 6,676 SH | Sept. 11, 2026 | Daily |
| DFAC · Dimensional ETF Trust | 0.00% | 8,234 NS | July 31, 2026 | N-PORT |
| DFUS · Dimensional ETF Trust | 0.00% | 2,793 NS | July 31, 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0.00% | 1,279 NS | July 31, 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 1,135,472 SH | Aug. 19, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 3,044 SH | Aug. 19, 2026 | Daily |
| ISCB · iShares Trust | · | 583 SH | Sept. 11, 2026 | Daily |
| ISCV · iShares Trust | · | 1,827 SH | Sept. 11, 2026 | Daily |
| SMMV · iShares Trust | · | 5,421 SH | Sept. 1, 2026 | Daily |
TYRA Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
rating · 21 analysts
BUY
Median target
$50.00
+134.5%
9 42.9%
Strong Buy
10 47.6%
Buy
2 9.5%
Hold
0 0.0%
Sell
0 0.0%
Strong Sell
12-Month Price Target
11 analysts · 2026-10-25Mean target $47.45 +122.6%
← Below all targets
Current price $21.32
Low$29.00
Mean$47.45
High$59.00
Peer comparison (GICS sub-industry) Key metrics vs sector peers
FY basis, prices as of each company's last fiscal year-end close.
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| TYRA | $1.41B | -13.1 | · | · | -42.7% | · |
| NVAX | $1.09B | 2.6 | 64.7% | 39.2% | -977.1% | · |
| RARE | $2.22B | -3.9 | 20.2% | -85.4% | -1613.2% | · |
| TRAX | · | · | · | · | · | · |
| ANAB | · | -105.4 | 157.0% | · | · | · |
| INBX | $1.15B | -8.7 | 550.0% | -10773.5% | -365.9% | · |
| FRNM | · | · | · | · | · | · |
| TSHA | $1.57B | -16.2 | 17.3% | -1115.3% | -44.0% | · |
| KRSA | · | · | · | · | · | · |
| DMRA | · | · | 38.3% | -17981.1% | -167.0% | · |
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Source: SEC 10-Q filed Aug 4, 2026