Insider at

04

Insider transactions

05
0 buys (P) 2 sells (S) Net: $-1,193,280 + 91 non-open-market transactions below 12 months to the week close of 2026-10-23

Price change vs the latest weekly close (updated to the current quote in your browser when available), split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

91 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
June 15, 2026 IONS S 10b5-1 8,000 $73.49 $587,920 156,013 Direct -4.88% Disposed -41.6% (price as of )
June 1, 2026 IONS S 10b5-1 8,000 $75.67 $605,360 156,013 Direct -4.88% Disposed -43.3% (price as of )
June 17, 2024 IONS S 16,000 $40.29 $644,640 147,257 Direct -9.80% Disposed 6.6% (price as of )
June 23, 2021 IONS S 10b5-1 15,000 $37.74 $566,100 100,983 Direct -12.93% Disposed 13.8% (price as of )
June 23, 2020 IONS S 10b5-1 15,000 $58.76 $881,400 96,983 Direct -13.39% Disposed -26.9% (price as of )
June 24, 2019 IONS S 10b5-1 5,310 $63.37 $336,495 94,094 Direct -5.34% Disposed -32.3% (price as of )
June 24, 2019 IONS S 10b5-1 9,690 $63.84 $618,610 94,094 Direct -9.34% Disposed -32.8% (price as of )
June 25, 2018 IONS S 10b5-1 5,700 $42.03 $239,571 91,427 Direct -5.87% Disposed 2.1% (price as of )
June 25, 2018 IONS S 10b5-1 9,300 $42.47 $394,971 91,427 Direct -9.23% Disposed 1.1% (price as of )

Loaded 100 of 174 rows

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
July 15, 2026 IONS Restricted Stock Unit Common Stock (5,220) · · 5,220 Disposed
July 1, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (5,369) $79.19 June 30, 2036 5,369 Acquired
July 1, 2026 IONS Restricted Stock Unit Common Stock (2,301) · · 2,301 Acquired
June 15, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (8,000) $24.42 June 30, 2026 8,000 Disposed
June 1, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (8,000) $24.42 June 30, 2026 8,000 Disposed
July 15, 2025 IONS Restricted Stock Unit Common Stock (4,079) · · 4,079 Disposed
July 1, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (11,518) $39.94 June 30, 2035 11,518 Acquired
July 1, 2025 IONS Restricted Stock Unit Common Stock (5,220) · · 5,220 Acquired
July 15, 2024 IONS Restricted Stock Unit Common Stock (4,677) · · 4,677 Disposed
July 1, 2024 IONS Non-Qualified Stock Option (right to buy) Common Stock (10,111) $47.11 June 30, 2034 10,111 Acquired
July 1, 2024 IONS Restricted Stock Unit Common Stock (4,079) · · 4,079 Acquired
June 17, 2024 IONS Non-Qualified Stock Option (right to buy) Common Stock (16,000) $35.53 June 30, 2024 16,000 Disposed
July 17, 2023 IONS Restricted Stock Unit Common Stock (1,777) · · 1,777 Disposed
July 17, 2023 IONS Restricted Stock Unit Common Stock (5,333) · · 5,333 Disposed
July 3, 2023 IONS Non-Qualified Stock Option (right to buy) Common Stock (10,321) $41.08 July 2, 2033 10,321 Acquired
July 3, 2023 IONS Restricted Stock Unit Common Stock (4,677) · · 4,677 Acquired
June 20, 2023 IONS Non-Qualified Stock Option (right to buy) Common Stock (11,250) $28.47 June 30, 2023 11,250 Disposed
July 15, 2022 IONS Restricted Stock Unit Common Stock (5,333) · · 5,333 Disposed
July 15, 2022 IONS Restricted Stock Unit Common Stock (2,665) · · 2,665 Disposed
July 1, 2022 IONS Non-Qualified Stock Option (right to buy) Common Stock (12,000) $38.06 June 30, 2032 12,000 Acquired
July 1, 2022 IONS Restricted Stock Unit Common Stock (5,333) · · 5,333 Acquired
June 7, 2022 IONS Non-Qualified Stock Option (right to buy) Common Stock (11,250) $12.94 July 1, 2022 11,250 Disposed
July 15, 2021 IONS Restricted Stock Unit Common Stock (5,333) · · 5,333 Disposed
July 15, 2021 IONS Restricted Stock Unit Common Stock (889) · · 889 Disposed
July 15, 2021 IONS Restricted Stock Unit Common Stock (666) · · 666 Disposed
July 15, 2021 IONS Restricted Stock Unit Common Stock (1,778) · · 1,778 Disposed
July 1, 2021 IONS Non-Qualified Stock Option (right to buy) Common Stock (12,000) $40.05 June 30, 2031 12,000 Acquired
July 1, 2021 IONS Restricted Stock Unit Common Stock (5,333) · · 5,333 Acquired
June 23, 2021 IONS Non-Qualified Stock Option (right to buy) Common Stock (15,000) $9.30 June 30, 2021 15,000 Disposed
July 6, 2020 IONS Restricted Stock Units Common Stock (667) · · 667 Disposed
July 2, 2020 IONS Restricted Stock Units Common Stock (889) · · 889 Disposed
July 1, 2020 IONS Restricted Stock Units Common Stock (666) · · 666 Disposed
July 1, 2020 IONS Restricted Stock Units Common Stock (1,778) · · 1,778 Disposed
July 1, 2020 IONS Restricted Stock Units Common Stock (5,333) · · 5,333 Acquired
July 1, 2020 IONS Director Stock Option (right to buy) Common Stock (12,000) $60.20 June 30, 2030 12,000 Acquired
June 23, 2020 IONS Director Stock Option (right to buy) Common Stock (15,000) $9.22 June 30, 2020 15,000 Disposed
July 3, 2019 IONS Restricted Stock Units Common Stock (667) · · 667 Disposed
July 2, 2019 IONS Restricted Stock Units Common Stock (889) · · 889 Disposed
July 1, 2019 IONS Restricted Stock Units Common Stock (666) · · 666 Disposed
July 1, 2019 IONS Restricted Stock Units Common Stock (667) · · 667 Disposed
July 1, 2019 IONS Restricted Stock Units Common Stock (7,110) · · 7,110 Acquired
July 1, 2019 IONS Director Stock Option (right to buy) Common Stock (16,000) $64.80 June 30, 2029 16,000 Acquired
June 24, 2019 IONS Director Stock Option (right to buy) Common Stock (15,000) $16.32 June 30, 2019 15,000 Disposed
July 3, 2018 IONS Restricted Stock Units Common Stock (667) · · 667 Disposed
July 2, 2018 IONS Restricted Stock Units Common Stock (3,555) · · 3,555 Acquired
July 2, 2018 IONS Director Stock Option (right to buy) Common Stock (16,000) $42.88 July 1, 2028 16,000 Acquired
July 1, 2018 IONS Restricted Stock Units Common Stock (2,000) · · 2,000 Disposed
June 25, 2018 IONS Director Stock Option (right to buy) Common Stock (15,000) $13.88 June 30, 2018 15,000 Disposed
July 3, 2017 IONS Restricted Stock Units Common Stock (2,667) · · 2,667 Acquired
July 3, 2017 IONS Director Stock Option (right to buy) Common Stock (16,000) $52.22 July 2, 2027 16,000 Acquired
July 1, 2017 IONS Restricted Stock Units Common Stock (2,469) · · 2,469 Disposed
Feb. 24, 2017 IONS Director Stock Option (right to buy) Common Stock (12,500) $9.77 July 1, 2017 12,500 Disposed
July 2, 2016 IONS Restricted Stock Units Common Stock (312) · · 312 Disposed
July 1, 2016 IONS Restricted Stock Units Common Stock (1,803) · · 1,803 Disposed
July 1, 2016 IONS Restricted Stock Units Common Stock (2,667) · · 2,667 Acquired
July 1, 2016 IONS Director Stock Option (right to buy) Common Stock (16,000) $24.42 June 30, 2026 16,000 Acquired
Feb. 19, 2016 IONS Director Stock Option (right to buy) Common Stock (12,500) $5.93 July 2, 2016 12,500 Disposed
July 2, 2015 IONS Restricted Stock Units Common Stock (312) · · 312 Disposed
July 1, 2015 IONS Restricted Stock Units Common Stock (469) · · 469 Disposed
July 1, 2015 IONS Restricted Stock Units Common Stock (667) · · 667 Disposed
July 1, 2015 IONS Restricted Stock Units Common Stock (2,667) · · 2,667 Acquired
July 1, 2015 IONS Director Stock Option (right to buy) Common Stock (16,000) $57.16 June 30, 2025 16,000 Acquired
April 17, 2015 IONS Director Stock Option (right to buy) Common Stock (10,000) $3.95 June 30, 2015 10,000 Acquired
July 2, 2014 IONS Restricted Stock Units Common Stock (313) · · 313 Disposed
July 1, 2014 IONS Restricted Stock Units Common Stock (469) · · 469 Disposed
July 1, 2014 IONS Restricted Stock Units Common Stock (2,667) · · 2,667 Acquired
July 1, 2014 IONS Director Stock Option (right to buy) Common Stock (16,000) $35.53 June 30, 2024 16,000 Acquired
April 17, 2014 IONS Employee Stock Option (right to buy) Common Stock (10,000) $5.72 June 30, 2014 10,000 Disposed
July 2, 2013 IONS Restricted Stock Units Common Stock (313) · · 313 Disposed
July 1, 2013 IONS Director Stock Option (right to buy) Common Stock (11,250) $28.47 June 30, 2023 11,250 Acquired
July 1, 2013 IONS Restricted Stock Units Common Stock (1,875) · · 1,875 Acquired
Feb. 21, 2013 IONS Director Stock Option (right to buy) Common Stock (10,000) $5.17 June 30, 2013 10,000 Disposed
July 2, 2012 IONS Restricted Stock Units Common Stock (1,250) · · 1,250 Acquired
July 2, 2012 IONS Director Stock Option (right to buy) Common Stock (11,250) $12.94 July 1, 2022 11,250 Acquired
June 25, 2012 IONS Director Stock Option (right to buy) Common Stock (10,000) $8.15 June 30, 2012 10,000 Disposed
May 22, 2012 IONS Director Stock Option (right to buy) Common Stock (17,269) $9.40 May 30, 2012 17,269 Disposed
May 21, 2012 IONS Director Stock Option (right to buy) Common Stock (2,731) $9.40 May 30, 2012 2,731 Disposed
July 1, 2011 IONS Director Stock Option (right to buy) Common Stock (15,000) $9.30 June 30, 2021 15,000 Acquired
July 1, 2010 IONS Director Stock Option (right to buy) Common Stock (15,000) $9.22 June 30, 2020 15,000 Acquired
July 1, 2009 IONS Director Stock Option (right to buy) Common Stock (15,000) $16.32 June 30, 2019 15,000 Acquired
July 1, 2008 IONS Director Stock Option (right to buy) Common Stock (15,000) $13.88 June 30, 2018 15,000 Acquired
July 2, 2007 IONS Director Stock Option (right to buy) Common Stock (12,500) $9.77 July 1, 2017 12,500 Acquired
July 3, 2006 IONS Director Stock Option (right to buy) Common Stock (12,500) $5.93 July 2, 2016 12,500 Acquired
July 1, 2005 IONS Director Stock Option (right to buy) Common Stock (10,000) $3.95 June 30, 2015 10,000 Acquired
July 1, 2004 IONS Director Stock Option (right to buy) Common Stock (10,000) $5.72 June 30, 2014 10,000 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Holdings reported on Form 4 30 reported holdings

08

Positions listed on each Form 4 without a transaction in that filing (Table I and II holdings), newest filing first.

DateTickerSecuritySharesExercise priceExpirationOwnership
July 17, 2026 IONS Common Stock 70 · · Indirect
June 16, 2026 IONS Common Stock 70 · · Indirect
June 3, 2026 IONS Common Stock 70 · · Indirect
July 17, 2025 IONS Common Stock 70 · · Indirect
July 17, 2024 IONS Common Stock 70 · · Indirect
June 20, 2024 IONS Common Stock 70 · · Indirect
July 19, 2023 IONS Common Stock 70 · · Indirect
June 22, 2023 IONS Common Stock 70 · · Indirect
July 19, 2022 IONS Common Stock 70 · · Indirect
June 9, 2022 IONS Common Stock 70 · · Indirect
July 19, 2021 IONS Common Stock 70 · · Indirect
June 25, 2021 IONS Common Stock 70 · · Indirect
July 6, 2020 IONS Common Stock 70 · · Indirect
June 25, 2020 IONS Common Stock 70 · · Indirect
July 3, 2019 IONS Common Stock 70 · · Indirect
June 26, 2019 IONS Common Stock 70 · · Indirect
July 3, 2018 IONS Common Stock 70 · · Indirect
June 25, 2018 IONS Common Stock 70 · · Indirect
July 3, 2017 IONS Common Stock 70 · · Indirect
Feb. 27, 2017 IONS Common Stock 70 · · Indirect
July 6, 2016 IONS Common Stock 70 · · Indirect
Feb. 22, 2016 IONS Common Stock 70 · · Indirect
July 2, 2015 IONS Common Stock 70 · · Indirect
April 17, 2015 IONS Common Stock 70 · · Indirect
July 2, 2014 IONS Common Stock 70 · · Indirect
April 17, 2014 IONS Common Stock 70 · · Indirect
July 3, 2013 IONS Common Stock 70 · · Indirect
Feb. 22, 2013 IONS Common Stock 70 · · Indirect
June 25, 2012 IONS Common Stock 70 · · Indirect
May 22, 2012 IONS Common Stock 70 · · Indirect