Insider at

04

Insider transactions

05
0 buys (P) 22 sells (S) Net: $-19,402,305 + 42 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

42 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
Feb. 27, 2026 KRYS S 10b5-1 9,430 $275.45 $2,597,494 75,666 Indirect -11.08% Disposed 17.0% (price as of 2026-10-02)
Feb. 27, 2026 KRYS S 10b5-1 2,373 $276.17 $655,351 73,293 Indirect -3.14% Disposed 16.7% (price as of 2026-10-02)
Feb. 26, 2026 KRYS S 10b5-1 5,103 $275.28 $1,404,754 87,734 Indirect -5.50% Disposed 17.1% (price as of 2026-10-02)
Feb. 26, 2026 KRYS S 10b5-1 2,638 $276.32 $728,932 85,096 Indirect -3.01% Disposed 16.6% (price as of 2026-10-02)
Feb. 25, 2026 KRYS S 10b5-1 700 $275.00 $192,500 92,837 Indirect -0.75% Disposed 17.2% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 569 $262.91 $149,596 37,326 Direct -1.50% Disposed 22.6% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 1,733 $264.12 $457,720 35,593 Direct -4.64% Disposed 22.0% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 3,557 $265.08 $942,890 32,036 Direct -9.99% Disposed 21.6% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 8,986 $266.18 $2,391,893 23,050 Direct -28.05% Disposed 21.1% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 11,673 $266.97 $3,116,341 11,377 Direct -50.64% Disposed 20.7% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 6,671 $268.04 $1,788,095 4,706 Direct -58.64% Disposed 20.2% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 3,963 $268.97 $1,065,928 743 Direct -84.21% Disposed 19.8% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 370 $269.83 $99,837 373 Direct -49.80% Disposed 19.4% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 373 $271.09 $101,117 0 Direct -100.00% Disposed 18.9% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 62 $263.05 $16,309 107,300 Indirect -0.06% Disposed 22.5% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 900 $264.60 $238,140 106,400 Indirect -0.84% Disposed 21.8% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 1,604 $265.54 $425,926 104,796 Indirect -1.51% Disposed 21.4% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 4,339 $266.62 $1,156,864 100,457 Indirect -4.14% Disposed 20.9% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 1,891 $267.37 $505,597 98,566 Indirect -1.88% Disposed 20.5% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 1,674 $268.67 $449,754 96,892 Indirect -1.70% Disposed 20.0% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 930 $269.50 $250,635 95,962 Indirect -0.96% Disposed 19.6% (price as of 2026-10-02)
Feb. 24, 2026 KRYS S 10b5-1 2,425 $274.90 $666,632 93,537 Indirect -2.53% Disposed 17.2% (price as of 2026-10-02)
June 9, 2023 KRYS S 3,935 $129.29 $508,756 122,362 Indirect -3.12% Disposed 149.3% (price as of 2026-10-02)
June 9, 2023 KRYS S 5,000 $128.84 $644,200 117,362 Indirect -4.09% Disposed 150.1% (price as of 2026-10-02)
June 9, 2023 KRYS S 10,000 $128.53 $1,285,300 107,362 Indirect -8.52% Disposed 150.7% (price as of 2026-10-02)
June 8, 2023 KRYS S 4,604 $127.96 $589,128 152,758 Indirect -2.93% Disposed 151.9% (price as of 2026-10-02)
June 8, 2023 KRYS S 1,073 $129.02 $138,438 151,685 Indirect -0.70% Disposed 149.8% (price as of 2026-10-02)
June 8, 2023 KRYS S 5,388 $128.73 $693,597 146,297 Indirect -3.55% Disposed 150.4% (price as of 2026-10-02)
June 8, 2023 KRYS S 5,000 $127.96 $639,800 141,297 Indirect -3.42% Disposed 151.9% (price as of 2026-10-02)
June 8, 2023 KRYS S 10,000 $127.96 $1,279,600 131,297 Indirect -7.08% Disposed 151.9% (price as of 2026-10-02)
June 8, 2023 KRYS S 5,000 $127.86 $639,300 126,297 Indirect -3.81% Disposed 152.1% (price as of 2026-10-02)
May 19, 2023 KRYS S 10b5-1 50,000 $95.02 $4,751,000 157,362 Indirect -24.11% Disposed 239.2% (price as of 2026-10-02)
May 9, 2023 KRYS S 10b5-1 17,100 $90.74 $1,551,654 207,362 Indirect -7.62% Disposed 255.2% (price as of 2026-10-02)
April 19, 2023 KRYS S 10b5-1 7,900 $90.32 $713,528 224,462 Indirect -3.40% Disposed 256.8% (price as of 2026-10-02)
Dec. 10, 2021 KRYS S 100,000 $70.50 $7,050,000 266,362 Indirect -27.30% Disposed 357.1% (price as of 2026-10-02)
Aug. 30, 2019 KRYS S 32,190 $46.18 $1,486,534 366,362 Indirect -8.08% Disposed 597.9% (price as of 2026-10-02)
Aug. 29, 2019 KRYS S 700 $47.50 $33,250 398,552 Indirect -0.18% Disposed 578.5% (price as of 2026-10-02)
Aug. 29, 2019 KRYS S 55,794 $46.61 $2,600,558 399,252 Indirect -12.26% Disposed 591.4% (price as of 2026-10-02)
Sept. 22, 2017 KRYS P 200,000 $10.00 $2,000,000 330,590 Indirect +153.15% Acquired 3122.8% (price as of 2026-10-02)
March 21, 2017 ESPR S 700 $48.19 $33,733 1,359,967 Indirect -0.05% Disposed
March 21, 2017 ESPR S 56,855 $47.54 $2,702,887 1,360,667 Indirect -4.01% Disposed
March 21, 2017 ESPR S 59,798 $46.60 $2,786,587 1,417,522 Indirect -4.05% Disposed
March 21, 2017 ESPR S 111,307 $45.43 $5,056,677 1,477,320 Indirect -7.01% Disposed
March 21, 2017 ESPR S 121,340 $44.91 $5,449,379 1,588,627 Indirect -7.10% Disposed
Oct. 21, 2014 ESPR P 500,000 $20.00 $10,000,000 2,552,189 Indirect +24.36% Acquired
July 1, 2013 ESPR P 235,714 $14.00 $3,299,996 2,052,189 Indirect +12.98% Acquired

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
Sept. 14, 2026 KRYS Stock Option (Right to Buy) Common Stock (1,187) $340.03 Sept. 13, 2036 1,187 Acquired
Sept. 14, 2026 KRYS Restricted Stock Award Common Stock (471) · · 471 Acquired
Feb. 24, 2026 KRYS Stock Option (Right to Buy) Common Stock (37,895) $2.46 Nov. 9, 2026 37,895 Disposed
June 30, 2025 KRYS Stock Option (Right to Buy) Common Stock (5,000) $137.46 June 30, 2035 5,000 Acquired
June 30, 2024 KRYS Stock Option (Right to Buy) Common Stock (5,000) $183.64 June 30, 2034 5,000 Acquired
June 30, 2023 KRYS Stock Option (Right to Buy) Common Stock (6,800) $117.40 June 30, 2033 6,800 Acquired
June 30, 2022 KRYS Stock Option (Right to Buy) Common Stock (6,800) $65.66 June 30, 2032 6,800 Acquired
June 30, 2021 KRYS Stock Option (Right to Buy) Common Stock (6,800) $68.00 June 30, 2031 6,800 Acquired
June 30, 2020 KRYS Stock Option (Right to Buy) Common Stock (6,800) $41.42 June 29, 2030 6,800 Acquired
June 17, 2019 STRO Stock Option (right to buy Common Stock) Common Stock (11,610) $11.12 June 16, 2029 11,610 Acquired
Oct. 1, 2018 STRO Series E Preferred Stock Common Stock (514,211) · · 18,698,578 Disposed
Oct. 1, 2018 STRO Series D Preferred Stock Common Stock (382,698) · · 9,449,318 Disposed
Oct. 1, 2018 STRO Series C Preferred Stock Common Stock (458,331) · · 12,387,324 Disposed
Oct. 1, 2018 STRO Series B Preferred Stock Common Stock (589,661) · · 10,201,769 Disposed
Sept. 26, 2018 STRO Stock Option (right to buy Common Stock) Common Stock (26,033) $15.00 Sept. 25, 2028 26,033 Acquired
May 31, 2018 KRYS Stock Option (Right to Buy) Common Stock (7,500) $10.29 May 31, 2028 7,500 Acquired
May 23, 2018 ESPR Stock Option (right to buy) Common Stock (10,100) $38.32 May 23, 2028 10,100 Acquired
Jan. 18, 2018 ESPR Warrant to Purchase Common Stock Common Stock (71,237) $6.99 Feb. 12, 2018 71,237 Disposed
Sept. 22, 2017 KRYS Series A Convertible Preferred Stock Common Stock (124,456) · · 124,456 Disposed
April 17, 2017 ESPR Stock Option (right to buy) Common Stock (14,000) $38.96 April 17, 2027 14,000 Acquired
June 9, 2016 ESPR Stock Option (right to buy) Common Stock (8,000) $17.75 June 9, 2026 8,000 Acquired
May 14, 2015 ESPR Stock Option (right to buy) Common Stock (8,000) $107.74 May 14, 2025 8,000 Acquired
May 15, 2014 ESPR Stock Option (right to buy) Common Stock (5,000) $14.42 May 15, 2024 5,000 Acquired
July 1, 2013 ESPR Warrant to Purchase Common Stock Common Stock (71,237) · Feb. 12, 2018 71,237 Acquired
July 1, 2013 ESPR Warrant to Purchase Preferred Stock Series A Preferred Stock (497,666) · Feb. 12, 2018 497,666 Disposed
July 1, 2013 ESPR Series A Preferred Stock Common Stock (1,816,475) · · 1,816,475 Disposed

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 15 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Sept. 26, 2018 STRO No securities beneficially held 0 Direct
Sept. 26, 2018 STRO Series B Preferred Stock→ Common Stock (10,201,769) 10,201,769 Indirect
Sept. 26, 2018 STRO Series C Preferred Stock→ Common Stock (12,387,324) 12,387,324 Indirect
Sept. 26, 2018 STRO Series D Preferred Stock→ Common Stock (9,449,318) 9,449,318 Indirect
Sept. 26, 2018 STRO Series E Preferred Stock→ Common Stock (18,698,578) 18,698,578 Indirect
Sept. 26, 2018 STRO Series C Preferred Stock Warrant (right to buy)→ Series C Preferred Stock (671,997) 671,997 Indirect
Sept. 25, 2017 KRYS Common Stock 130,590 Indirect
Sept. 25, 2017 KRYS Series A Convertible Preferred Stock [F4]→ Common Stock · Indirect
Sept. 25, 2017 KRYS Stock Option (Right to Buy)→ Common Stock (37,894) 37,894 Direct
Sept. 19, 2017 KRYS Common Stock 130,590 Direct
Sept. 19, 2017 KRYS Series A Convertible Preferred Stock [F1] 124,456 Indirect
Sept. 19, 2017 KRYS Stock Option (Right to Buy)→ Common Stock (37,894) 37,894 Direct
June 25, 2013 ESPR Series A Preferred Stock→ Common Stock (1,816,475) 1,816,475 Indirect
June 25, 2013 ESPR Warrant to Purchase Preferred Stock→ Series A Preferred Stock · Indirect
June 25, 2013 ESPR Stock Option (right to buy)→ Common Stock (21,471) 21,471 Direct