Insider at

04

Insider transactions

05
0 buys (P) 4 sells (S) Net: $-3,738,554 + 49 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

49 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
June 26, 2026 IONS S 10b5-1 26,000 $81.05 $2,107,300 77,114 Direct -25.21% Disposed -46.3% (price as of 2026-10-02)
March 19, 2026 IONS S 10b5-1 5,812 $70.97 $412,478 63,890 Direct -8.34% Disposed -38.7% (price as of 2026-10-02)
Jan. 30, 2026 IONS S 6,179 $83.45 $515,638 69,702 Direct -8.14% Disposed -47.8% (price as of 2026-10-02)
Jan. 16, 2026 IONS S 9,302 $75.59 $703,138 63,890 Direct -12.71% Disposed -42.4% (price as of 2026-10-02)
Sept. 3, 2025 IONS S 10b5-1 7,203 $61.42 $442,408 51,507 Direct -12.27% Disposed -29.1% (price as of 2026-10-02)
Sept. 3, 2025 IONS S 10b5-1 12,455 $60.46 $753,029 58,710 Direct -17.50% Disposed -28.0% (price as of 2026-10-02)
Aug. 4, 2025 IONS S 10b5-1 9,549 $42.80 $408,697 51,507 Direct -15.64% Disposed 1.7% (price as of 2026-10-02)
Jan. 31, 2025 IONS S 1,484 $32.20 $47,785 61,056 Direct -2.37% Disposed 35.2% (price as of 2026-10-02)
Jan. 16, 2025 IONS S 6,523 $32.79 $213,889 58,508 Direct -10.03% Disposed 32.8% (price as of 2026-10-02)
Feb. 2, 2024 IONS S 2,106 $49.59 $104,437 47,659 Direct -4.23% Disposed -12.2% (price as of 2026-10-02)
Feb. 2, 2024 IONS S 2,071 $49.59 $102,701 49,812 Direct -3.99% Disposed -12.2% (price as of 2026-10-02)
Jan. 17, 2024 IONS S 5,482 $50.42 $276,402 47,850 Direct -10.28% Disposed -13.6% (price as of 2026-10-02)
Jan. 12, 2024 IONS S 8,000 $53.50 $428,000 38,170 Direct -17.33% Disposed -18.6% (price as of 2026-10-02)
Dec. 26, 2023 IONS S 25,000 $51.46 $1,286,500 36,052 Direct -40.95% Disposed -15.4% (price as of 2026-10-02)
Feb. 6, 2023 IONS S 1,413 $40.67 $57,467 24,946 Direct -5.36% Disposed 7.1% (price as of 2026-10-02)
Jan. 18, 2023 IONS S 4,752 $39.57 $188,037 22,326 Direct -17.55% Disposed 10.0% (price as of 2026-10-02)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
June 26, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (26,000) $60.89 Jan. 1, 2027 26,000 Disposed
Jan. 15, 2026 IONS Restricted Stock Unit [F8] Common Stock (9,675) · · 9,675 Acquired
Jan. 15, 2026 IONS Restricted Stock Unit Common Stock (21,685) · · 21,685 Disposed
Jan. 15, 2026 IONS Performance Restricted Stock Units [F4] Common Stock (25,800) $0.00 · 25,800 Acquired
Jan. 2, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (19,350) $79.67 Jan. 1, 2036 19,350 Acquired
Sept. 3, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (19,658) $53.77 Jan. 1, 2026 19,658 Disposed
Jan. 15, 2025 IONS Restricted Stock Unit Common Stock (17,372) · · 17,372 Disposed
Jan. 15, 2025 IONS Restricted Stock Unit [F6] Common Stock (33,000) · · 33,000 Acquired
Jan. 15, 2025 IONS Performance Restricted Stock Units [F4] Common Stock (22,000) $0.00 · 22,000 Acquired
Jan. 2, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (22,000) $34.69 Jan. 1, 2035 22,000 Acquired
Jan. 16, 2024 IONS Restricted Stock Unit Common Stock (15,162) · · 15,162 Disposed
Jan. 15, 2024 IONS Restricted Stock Unit [F3] Common Stock (20,400) · · 20,400 Acquired
Jan. 15, 2024 IONS Performance Restricted Stock Units [F1] Common Stock (17,000) $0.00 · 17,000 Acquired
Jan. 12, 2024 IONS Non-Qualified Stock Option (right to buy) Common Stock (8,000) $32.60 Jan. 2, 2032 8,000 Disposed
Jan. 2, 2024 IONS Non-Qualified Stock Option (right to buy) Common Stock (27,200) $52.87 Jan. 1, 2034 27,200 Acquired
Dec. 26, 2023 IONS Non-Qualified Stock Option (right to buy) Common Stock (25,000) $47.34 Jan. 2, 2024 25,000 Disposed
Jan. 17, 2023 IONS Restricted Stock Unit Common Stock (13,046) · · 13,046 Disposed
Jan. 15, 2023 IONS Restricted Stock Unit [F3] Common Stock (17,207) · · 17,207 Acquired
Jan. 15, 2023 IONS Performance Restricted Stock Units [F1] Common Stock (14,338) $0.00 · 14,338 Acquired
Jan. 3, 2023 IONS Non-Qualified Stock Option (right to buy) Common Stock (22,942) $37.58 Jan. 2, 2033 22,942 Acquired
Oct. 17, 2022 IONS Restricted Stock Unit Common Stock (416) · · 416 Disposed
Jan. 18, 2022 IONS Restricted Stock Unit Common Stock (10,400) · · 10,400 Disposed
Jan. 15, 2022 IONS Restricted Stock Unit [F3] Common Stock (16,133) · · 16,133 Acquired
Jan. 15, 2022 IONS Performance Restricted Stock Units [F1] Common Stock (12,099) $0.00 · 12,099 Acquired
Jan. 3, 2022 IONS Non-Qualified Stock Option (right to buy) Common Stock (32,265) $32.60 Jan. 2, 2032 32,265 Acquired
Oct. 15, 2021 IONS Restricted Stock Unit Common Stock (417) · · 417 Disposed
Jan. 15, 2021 IONS Restricted Stock Units Common Stock (7,503) · · 7,503 Disposed
Jan. 15, 2021 IONS Restricted Stock Units Common Stock (15,753) · · 15,753 Acquired
Jan. 4, 2021 IONS Employee Stock Option (right to buy) Common Stock (35,444) $56.78 Jan. 3, 2028 35,444 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 15 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
April 19, 2023 IONS Common Stock [F1] 13,224 Direct
Jan. 6, 2021 IONS Common Stock 2,118 Direct
Jan. 6, 2021 IONS Employee Stock Option (right to buy)→ Common Stock (6,100) 6,100 Direct
Jan. 6, 2021 IONS Employee Stock Option (right to buy)→ Common Stock (18,750) 18,750 Direct
Jan. 6, 2021 IONS Employee Stock Option (right to buy)→ Common Stock (11,000) 11,000 Direct
Jan. 6, 2021 IONS Employee Stock Option (right to buy)→ Common Stock (25,000) 25,000 Direct
Jan. 6, 2021 IONS Employee Stock Option (right to buy)→ Common Stock (25,000) 25,000 Direct
Jan. 6, 2021 IONS Employee Stock Option (right to buy)→ Common Stock (7,500) 7,500 Direct
Jan. 6, 2021 IONS Employee Stock Option (right to buy)→ Common Stock (19,658) 19,658 Direct
Jan. 6, 2021 IONS Employee Stock Option (right to buy)→ Common Stock (26,000) 26,000 Direct
Jan. 6, 2021 IONS Restricted Stock Units→ Common Stock (1,041) 1,041 Direct
Jan. 6, 2021 IONS Restricted Stock Units→ Common Stock (2,777) 2,777 Direct
Jan. 6, 2021 IONS Restricted Stock Units→ Common Stock (833) 833 Direct
Jan. 6, 2021 IONS Restricted Stock Units→ Common Stock (6,552) 6,552 Direct
Jan. 6, 2021 IONS Restricted Stock Units→ Common Stock (11,556) 11,556 Direct