Insider at

04

Insider transactions

05
0 buys (P) 4 sells (S) Net: $-4,810,107 + 14 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

14 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
July 7, 2026 IONS S 10b5-1 362 $84.30 $30,517 22,096 Direct -1.61% Disposed -48.4% (price as of 2026-10-02)
June 12, 2026 IONS S 10b5-1 19,842 $74.05 $1,469,300 22,458 Direct -46.91% Disposed -41.2% (price as of 2026-10-02)
June 12, 2026 IONS S 10b5-1 41,004 $73.09 $2,996,982 42,300 Direct -49.22% Disposed -40.4% (price as of 2026-10-02)
Jan. 16, 2026 IONS S 4,141 $75.66 $313,308 14,718 Direct -21.96% Disposed -42.5% (price as of 2026-10-02)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
June 12, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (21,000) $60.89 Jan. 1, 2027 21,000 Disposed
June 12, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (7,951) $60.89 Jan. 1, 2027 7,951 Disposed
June 12, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (19,895) $56.78 Jan. 3, 2028 19,895 Disposed
June 12, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (12,000) $32.60 Jan. 2, 2032 12,000 Disposed
Jan. 15, 2026 IONS Restricted Stock Unit [F6] Common Stock (11,250) · · 11,250 Acquired
Jan. 15, 2026 IONS Restricted Stock Unit [F6] Common Stock (13,650) · · 13,650 Acquired
Jan. 15, 2026 IONS Restricted Stock Unit Common Stock (11,119) · · 11,119 Disposed
Jan. 2, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (7,500) $79.67 Jan. 1, 2036 7,500 Acquired
Jan. 2, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (9,100) $79.67 Jan. 1, 2036 9,100 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 8 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Jan. 6, 2026 IONS Common Stock 7,740 Direct
Jan. 6, 2026 IONS Non-Qualified Stock Option (right to buy)→ Common Stock (12,000) 12,000 Direct
Jan. 6, 2026 IONS Non-Qualified Stock Option (right to buy)→ Common Stock (10,000) 10,000 Direct
Jan. 6, 2026 IONS Non-Qualified Stock Option (right to buy)→ Common Stock (11,500) 11,500 Direct
Jan. 6, 2026 IONS Non-Qualified Stock Option (right to buy)→ Common Stock (19,800) 19,800 Direct
Jan. 6, 2026 IONS Non-Qualified Stock Option (right to buy)→ Common Stock (19,895) 19,895 Direct
Jan. 6, 2026 IONS Non-Qualified Stock Option (right to buy)→ Common Stock (28,951) 28,951 Direct
Jan. 6, 2026 IONS Restricted Stock Unit [F1]→ Common Stock (31,949) 31,949 Direct