Joseph Loscalzo

CIK 1276128 · View on SEC EDGAR ↗

Insider

First SEC filing: May 6, 2026 · Latest: May 6, 2026

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Insider at

Insider transactions

0 buys (P) 6 sells (S) Net: $-8,047,872 + 93 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

93 other filings hidden
Date Ticker Code Shares Price Value Owned after Δ own A/D vs now
May 4, 2026 IONS S 10b5-1 17,781 $75.58 $1,343,888 36,330 Direct -32.86% Disposed -20.8% (price as of 2026-08-21)
May 4, 2026 IONS S 10b5-1 59,508 $74.90 $4,457,149 54,111 Direct -52.38% Disposed -20.1% (price as of 2026-08-21)
March 4, 2026 IONS S 10b5-1 200 $80.00 $16,000 36,330 Direct -0.55% Disposed -25.1% (price as of 2026-08-21)
March 3, 2026 IONS S 10b5-1 832 $80.33 $66,835 36,330 Direct -2.24% Disposed -25.5% (price as of 2026-08-21)
Oct. 31, 2025 IONS S 10b5-1 16,000 $75.10 $1,201,600 36,330 Direct -30.58% Disposed -20.3% (price as of 2026-08-21)
Sept. 3, 2025 IONS S 10b5-1 16,000 $60.15 $962,400 36,330 Direct -30.58% Disposed -0.4% (price as of 2026-08-21)
Nov. 12, 2024 IONS S 10b5-1 13,508 $37.86 $511,413 32,251 Direct -29.52% Disposed 58.2% (price as of 2026-08-21)

Showing latest 100 of 131 transactions

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II)

Options, RSUs and convertible securities reported on Form 4 Table II.

Date Ticker Security Underlying Exercise price Expiration Shares A/D
July 1, 2026 IONS Restricted Stock Unit Common Stock (2,301) — — 2,301 Acquired
July 1, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (5,369) $79.19 June 30, 2036 5,369 Acquired
May 4, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (16,000) $64.80 June 30, 2029 16,000 Disposed
May 4, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (12,000) $60.20 June 30, 2030 12,000 Disposed
May 4, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (16,000) $42.88 July 1, 2028 16,000 Disposed
May 4, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (10,321) $41.08 July 2, 2033 10,321 Disposed
May 4, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (12,000) $40.05 June 30, 2031 12,000 Disposed
May 4, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (10,968) $38.06 June 30, 2032 10,968 Disposed
March 13, 2026 CYPH Restricted Stock Units Common Stock (74,700) $0.00 — 74,700 Disposed
March 13, 2026 CYPH Restricted Stock Units Common Stock (94,050) $0.00 — 94,050 Disposed
March 4, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (200) $38.06 June 30, 2032 200 Disposed
March 3, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (832) $38.06 June 30, 2032 832 Disposed
Dec. 23, 2025 CYPH Restricted Stock Units Common Stock (94,050) — — 94,050 Acquired
Nov. 11, 2025 CYPH Restricted Stock Units Common Stock (74,700) — — 74,700 Acquired
Oct. 31, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (16,000) $52.22 July 2, 2027 16,000 Disposed
Sept. 3, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (16,000) $24.42 June 30, 2026 16,000 Disposed
July 15, 2025 IONS Restricted Stock Unit Common Stock (4,079) — — 4,079 Disposed
July 1, 2025 IONS Restricted Stock Unit Common Stock (5,220) — — 5,220 Acquired
July 1, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (11,518) $39.94 June 30, 2035 11,518 Acquired
Oct. 2, 2024 CYPH Stock Option (Right to Buy) Common Stock (25,000) $2.45 Oct. 2, 2034 25,000 Acquired
July 15, 2024 IONS Restricted Stock Unit Common Stock (4,677) — — 4,677 Disposed
July 1, 2024 IONS Restricted Stock Unit Common Stock (4,079) — — 4,079 Acquired
July 1, 2024 IONS Non-Qualified Stock Option (right to buy) Common Stock (10,111) $47.11 June 30, 2034 10,111 Acquired
Jan. 29, 2024 CYPH Stock Option (Right to Buy) Common Stock (25,000) $2.68 Jan. 29, 2034 25,000 Acquired
Aug. 23, 2023 CYPH Stock Option (Right to Buy) Common Stock (15,000) $2.21 Aug. 23, 2033 15,000 Acquired
July 17, 2023 IONS Restricted Stock Unit Common Stock (5,333) — — 5,333 Disposed
July 17, 2023 IONS Restricted Stock Unit Common Stock (1,777) — — 1,777 Disposed
July 3, 2023 IONS Restricted Stock Unit Common Stock (4,677) — — 4,677 Acquired
July 3, 2023 IONS Non-Qualified Stock Option (right to buy) Common Stock (10,321) $41.08 July 2, 2033 10,321 Acquired
March 31, 2023 CYPH Stock Option (Right to Buy) Common Stock (150,000) $0.34 March 31, 2033 150,000 Acquired
Sept. 1, 2022 CYPH Stock Option (Right to Buy) Common Stock (25,000) $1.43 Aug. 31, 2032 25,000 Acquired
July 15, 2022 IONS Restricted Stock Unit Common Stock (2,665) — — 2,665 Disposed
July 15, 2022 IONS Restricted Stock Unit Common Stock (5,333) — — 5,333 Disposed
July 1, 2022 IONS Non-Qualified Stock Option (right to buy) Common Stock (12,000) $38.06 June 30, 2032 12,000 Acquired
July 1, 2022 IONS Restricted Stock Unit Common Stock (5,333) — — 5,333 Acquired
Jan. 31, 2022 CYPH Stock Option (Right to Buy) Common Stock (55,000) $1.94 Jan. 30, 2032 55,000 Acquired
July 15, 2021 IONS Restricted Stock Unit Common Stock (1,778) — — 1,778 Disposed
July 15, 2021 IONS Restricted Stock Unit Common Stock (666) — — 666 Disposed
July 15, 2021 IONS Restricted Stock Unit Common Stock (889) — — 889 Disposed
July 15, 2021 IONS Restricted Stock Unit Common Stock (5,333) — — 5,333 Disposed
July 1, 2021 IONS Restricted Stock Unit Common Stock (5,333) — — 5,333 Acquired
July 1, 2021 IONS Non-Qualified Stock Option (right to buy) Common Stock (12,000) $40.05 June 30, 2031 12,000 Acquired
Jan. 4, 2021 CYPH Stock Option (Right to Buy) Common Stock (32,300) $2.18 Jan. 3, 2031 32,300 Acquired
Aug. 10, 2020 CYPH Stock Option (Right to Buy) Common Stock (10,000) $1.97 Aug. 9, 2030 10,000 Acquired
July 6, 2020 IONS Restricted Stock Units Common Stock (667) — — 667 Disposed
July 2, 2020 IONS Restricted Stock Units Common Stock (889) — — 889 Disposed
July 1, 2020 IONS Director Stock Option (right to buy) Common Stock (12,000) $60.20 June 30, 2030 12,000 Acquired
July 1, 2020 IONS Restricted Stock Units Common Stock (5,333) — — 5,333 Acquired
July 1, 2020 IONS Restricted Stock Units Common Stock (1,778) — — 1,778 Disposed
July 1, 2020 IONS Restricted Stock Units Common Stock (666) — — 666 Disposed
April 9, 2020 CYPH Stock Option (Right to Buy) Common Stock (10,000) $1.69 April 9, 2030 10,000 Acquired
March 2, 2020 CYPH Stock Option (Right to Buy) Common Stock (20,000) $2.94 March 1, 2030 20,000 Acquired
July 3, 2019 IONS Restricted Stock Units Common Stock (667) — — 667 Disposed
July 2, 2019 IONS Restricted Stock Units Common Stock (889) — — 889 Disposed
July 1, 2019 IONS Director Stock Option (right to buy) Common Stock (16,000) $64.80 June 30, 2029 16,000 Acquired
July 1, 2019 IONS Restricted Stock Units Common Stock (7,110) — — 7,110 Acquired
July 1, 2019 IONS Restricted Stock Units Common Stock (667) — — 667 Disposed
July 1, 2019 IONS Restricted Stock Units Common Stock (666) — — 666 Disposed
June 11, 2019 CYPH Stock Option (Right to Buy) Common Stock (10,000) $1.39 June 10, 2029 10,000 Acquired
Jan. 1, 2019 CYPH Stock Option (Right to Buy) Common Stock (7,500) $2.00 Dec. 31, 2028 7,500 Acquired
July 3, 2018 IONS Restricted Stock Units Common Stock (667) — — 667 Disposed
July 2, 2018 IONS Director Stock Option (right to buy) Common Stock (16,000) $42.88 July 1, 2028 16,000 Acquired
July 2, 2018 IONS Restricted Stock Units Common Stock (3,555) — — 3,555 Acquired
July 1, 2018 IONS Restricted Stock Units Common Stock (2,000) — — 2,000 Disposed
April 18, 2018 CYPH Stock Option (Right to Buy) Common Stock, $0.001 par value per share $7.66 April 17, 2028 11,250 Acquired
Feb. 3, 2018 IONS Restricted Stock Units Common Stock (937) — — 937 Disposed
July 3, 2017 IONS Director Stock Option (right to buy) Common Stock (16,000) $52.22 July 2, 2027 16,000 Acquired
July 3, 2017 IONS Restricted Stock Units Common Stock (2,667) — — 2,667 Acquired
July 1, 2017 IONS Restricted Stock Units Common Stock (2,001) — — 2,001 Disposed
Feb. 3, 2017 IONS Restricted Stock Units Common Stock (937) — — 937 Disposed
Jan. 23, 2017 CYPH Stock Option (Right to Buy) Common Stock, $0.001 par value per share $9.90 Jan. 22, 2027 15,000 Acquired
Jan. 23, 2017 CYPH Stock Option (Right to Buy) Common Stock, $0.001 par value per share $9.90 Jan. 22, 2027 11,000 Acquired
July 1, 2016 IONS Director Stock Option (right to buy) Common Stock (16,000) $24.42 June 30, 2026 16,000 Acquired
July 1, 2016 IONS Restricted Stock Units Common Stock (2,667) — — 2,667 Acquired
July 1, 2016 IONS Restricted Stock Units Common Stock (1,334) — — 1,334 Disposed
Feb. 3, 2016 IONS Restricted Stock Units Common Stock (938) — — 938 Disposed
July 1, 2015 IONS Director Stock Option (right to buy) Common Stock (16,000) $57.16 June 30, 2025 16,000 Acquired
July 1, 2015 IONS Restricted Stock Units Common Stock (2,667) — — 2,667 Acquired
July 1, 2015 IONS Restricted Stock Units Common Stock (667) — — 667 Disposed
Feb. 3, 2015 IONS Restricted Stock Units Common Stock (938) — — 938 Disposed
July 1, 2014 IONS Director Stock Option (right to buy) Common Stock (16,000) $35.53 June 30, 2024 16,000 Acquired
July 1, 2014 IONS Restricted Stock Units Common Stock (2,667) — — 2,667 Acquired
Feb. 3, 2014 IONS Restricted Stock Units Common Stock (3,750) — — 3,750 Acquired
Feb. 3, 2014 IONS Director Stock Option (right to buy) Common Stock (22,500) $49.09 Feb. 2, 2024 22,500 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 1 holding

Securities held when first becoming an insider, per SEC Form 3.

Date Ticker Security Shares Ownership
Feb. 5, 2014 IONS No Securities Owned 0 Direct