Insider at

04

Insider transactions

05
0 buys (P) 66 sells (S) Net: $-9,634,415 + 14 non-open-market transactions below 12 months to the week close of 2026-10-23

Price change vs the latest weekly close (updated to the current quote in your browser when available), split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

14 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
March 5, 2026 ALNY S 10b5-1 124 $321.81 $39,904 21,103 Direct -0.58% Disposed -30.4% (price as of )
March 5, 2026 ALNY S 10b5-1 233 $323.25 $75,317 20,870 Direct -1.10% Disposed -30.7% (price as of )
March 5, 2026 ALNY S 10b5-1 148 $324.60 $48,041 20,722 Direct -0.71% Disposed -31.0% (price as of )
March 5, 2026 ALNY S 10b5-1 153 $326.24 $49,915 20,569 Direct -0.74% Disposed -31.3% (price as of )
March 4, 2026 ALNY S 29 $319.03 $9,252 21,831 Direct -0.13% Disposed -29.8% (price as of )
March 4, 2026 ALNY S 28 $320.01 $8,960 21,803 Direct -0.13% Disposed -30.0% (price as of )
March 4, 2026 ALNY S 59 $320.81 $18,928 21,744 Direct -0.27% Disposed -30.2% (price as of )
March 4, 2026 ALNY S 79 $321.82 $25,424 21,665 Direct -0.36% Disposed -30.4% (price as of )
March 4, 2026 ALNY S 96 $323.01 $31,009 21,569 Direct -0.44% Disposed -30.6% (price as of )
March 4, 2026 ALNY S 210 $323.84 $68,006 21,359 Direct -0.97% Disposed -30.8% (price as of )
March 4, 2026 ALNY S 75 $324.88 $24,366 21,284 Direct -0.35% Disposed -31.0% (price as of )
March 4, 2026 ALNY S 57 $325.67 $18,563 21,227 Direct -0.27% Disposed -31.2% (price as of )
March 3, 2026 ALNY S 10b5-1 289 $316.55 $91,483 23,223 Direct -1.23% Disposed -29.2% (price as of )
March 3, 2026 ALNY S 10b5-1 282 $318.62 $89,851 22,941 Direct -1.21% Disposed -29.7% (price as of )
March 3, 2026 ALNY S 10b5-1 722 $320.51 $231,408 22,219 Direct -3.15% Disposed -30.1% (price as of )
March 3, 2026 ALNY S 10b5-1 359 $321.58 $115,447 21,860 Direct -1.62% Disposed -30.3% (price as of )
March 2, 2026 ALNY S 47 $323.62 $15,210 25,063 Direct -0.19% Disposed -30.8% (price as of )
March 2, 2026 ALNY S 90 $324.65 $29,218 24,973 Direct -0.36% Disposed -31.0% (price as of )
March 2, 2026 ALNY S 258 $325.63 $84,013 24,715 Direct -1.03% Disposed -31.2% (price as of )
March 2, 2026 ALNY S 392 $326.81 $128,110 24,323 Direct -1.59% Disposed -31.4% (price as of )
March 2, 2026 ALNY S 329 $327.67 $107,803 23,994 Direct -1.35% Disposed -31.6% (price as of )
March 2, 2026 ALNY S 100 $328.71 $32,871 23,894 Direct -0.42% Disposed -31.8% (price as of )
March 2, 2026 ALNY S 170 $329.71 $56,051 23,724 Direct -0.71% Disposed -32.1% (price as of )
March 2, 2026 ALNY S 81 $330.85 $26,799 23,643 Direct -0.34% Disposed -32.3% (price as of )
March 2, 2026 ALNY S 94 $331.93 $31,201 23,549 Direct -0.40% Disposed -32.5% (price as of )
March 2, 2026 ALNY S 37 $332.64 $12,308 23,512 Direct -0.16% Disposed -32.7% (price as of )
Feb. 17, 2026 ALNY S 10b5-1 2,041 $331.96 $677,530 21,264 Direct -8.76% Disposed -32.5% (price as of )
Feb. 13, 2026 ALNY S 1,959 $310.08 $607,447 23,305 Direct -7.75% Disposed -27.8% (price as of )
Jan. 13, 2026 ALNY S 10b5-1 197 $367.52 $72,401 23,357 Direct -0.84% Disposed -39.0% (price as of )
Jan. 13, 2026 ALNY S 10b5-1 562 $368.76 $207,243 22,795 Direct -2.41% Disposed -39.2% (price as of )
Jan. 13, 2026 ALNY S 10b5-1 644 $370.00 $238,280 22,151 Direct -2.83% Disposed -39.5% (price as of )
Jan. 13, 2026 ALNY S 10b5-1 485 $371.24 $180,051 21,666 Direct -2.19% Disposed -39.7% (price as of )
Jan. 13, 2026 ALNY S 10b5-1 280 $372.93 $104,420 21,386 Direct -1.29% Disposed -39.9% (price as of )
Jan. 13, 2026 ALNY S 10b5-1 122 $374.33 $45,668 21,264 Direct -0.57% Disposed -40.2% (price as of )
Jan. 12, 2026 ALNY S 39 $353.95 $13,804 25,025 Direct -0.16% Disposed -36.7% (price as of )
Jan. 12, 2026 ALNY S 42 $355.16 $14,917 24,983 Direct -0.17% Disposed -36.9% (price as of )
Jan. 12, 2026 ALNY S 41 $356.09 $14,600 24,942 Direct -0.16% Disposed -37.1% (price as of )
Jan. 12, 2026 ALNY S 96 $357.17 $34,288 24,846 Direct -0.38% Disposed -37.3% (price as of )
Jan. 12, 2026 ALNY S 123 $358.18 $44,056 24,723 Direct -0.50% Disposed -37.5% (price as of )
Jan. 12, 2026 ALNY S 85 $359.14 $30,527 24,638 Direct -0.34% Disposed -37.6% (price as of )
Jan. 12, 2026 ALNY S 155 $360.22 $55,834 24,483 Direct -0.63% Disposed -37.8% (price as of )
Jan. 12, 2026 ALNY S 98 $361.45 $35,422 24,385 Direct -0.40% Disposed -38.0% (price as of )
Jan. 12, 2026 ALNY S 73 $362.38 $26,454 24,312 Direct -0.30% Disposed -38.2% (price as of )
Jan. 12, 2026 ALNY S 47 $363.55 $17,087 24,265 Direct -0.19% Disposed -38.4% (price as of )
Jan. 12, 2026 ALNY S 199 $364.83 $72,601 24,066 Direct -0.82% Disposed -38.6% (price as of )
Jan. 12, 2026 ALNY S 220 $365.56 $80,423 23,846 Direct -0.91% Disposed -38.7% (price as of )
Jan. 12, 2026 ALNY S 50 $366.41 $18,320 23,796 Direct -0.21% Disposed -38.9% (price as of )
Jan. 12, 2026 ALNY S 41 $367.40 $15,063 23,755 Direct -0.17% Disposed -39.0% (price as of )
Jan. 12, 2026 ALNY S 92 $368.62 $33,913 23,663 Direct -0.39% Disposed -39.2% (price as of )
Jan. 12, 2026 ALNY S 40 $369.48 $14,779 23,623 Direct -0.17% Disposed -39.4% (price as of )
Jan. 12, 2026 ALNY S 19 $370.87 $7,047 23,604 Direct -0.08% Disposed -39.6% (price as of )
Jan. 12, 2026 ALNY S 2 $372.46 $745 23,602 Direct -0.01% Disposed -39.9% (price as of )
Jan. 12, 2026 ALNY S 14 $374.44 $5,242 23,588 Direct -0.06% Disposed -40.2% (price as of )
Jan. 12, 2026 ALNY S 19 $375.65 $7,137 23,569 Direct -0.08% Disposed -40.4% (price as of )
Jan. 12, 2026 ALNY S 15 $377.82 $5,667 23,554 Direct -0.06% Disposed -40.7% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 8,168 $449.00 $3,667,432 25,224 Direct -24.46% Disposed -50.1% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 96 $450.09 $43,209 25,128 Direct -0.38% Disposed -50.2% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 129 $451.51 $58,245 24,999 Direct -0.51% Disposed -50.4% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 368 $455.24 $167,528 24,631 Direct -1.47% Disposed -50.8% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 364 $456.25 $166,075 24,267 Direct -1.48% Disposed -50.9% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 262 $457.39 $119,836 24,005 Direct -1.08% Disposed -51.0% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 794 $458.41 $363,978 23,211 Direct -3.31% Disposed -51.1% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 622 $459.89 $286,052 22,589 Direct -2.68% Disposed -51.3% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 707 $460.84 $325,814 21,882 Direct -3.13% Disposed -51.4% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 323 $461.96 $149,213 21,559 Direct -1.48% Disposed -51.5% (price as of )
Nov. 17, 2025 ALNY S 10b5-1 295 $463.08 $136,609 21,264 Direct -1.37% Disposed -51.6% (price as of )
Oct. 2, 2025 ALNY S 96 $446.53 $42,867 27,576 Direct -0.35% Disposed -49.8% (price as of )
Oct. 2, 2025 ALNY S 47 $447.92 $21,052 27,529 Direct -0.17% Disposed -50.0% (price as of )
Oct. 2, 2025 ALNY S 150 $448.77 $67,316 27,379 Direct -0.54% Disposed -50.1% (price as of )
Oct. 2, 2025 ALNY S 207 $449.79 $93,107 27,172 Direct -0.76% Disposed -50.2% (price as of )
Oct. 2, 2025 ALNY S 449 $450.81 $202,414 26,723 Direct -1.65% Disposed -50.3% (price as of )
Oct. 2, 2025 ALNY S 276 $451.86 $124,713 26,447 Direct -1.03% Disposed -50.4% (price as of )
Oct. 2, 2025 ALNY S 555 $452.69 $251,243 25,892 Direct -2.10% Disposed -50.5% (price as of )
Oct. 2, 2025 ALNY S 273 $453.77 $123,879 25,619 Direct -1.05% Disposed -50.6% (price as of )
Oct. 2, 2025 ALNY S 203 $454.84 $92,333 25,416 Direct -0.79% Disposed -50.7% (price as of )
Oct. 2, 2025 ALNY S 60 $455.82 $27,349 25,356 Direct -0.24% Disposed -50.9% (price as of )
Oct. 2, 2025 ALNY S 122 $457.43 $55,806 25,234 Direct -0.48% Disposed -51.0% (price as of )
Oct. 2, 2025 ALNY S 3 $457.64 $1,373 25,231 Direct -0.01% Disposed -51.0% (price as of )
Aug. 18, 2025 ALNY S 39 $447.98 $17,471 24,076 Direct -0.16% Disposed -50.0% (price as of )
Aug. 18, 2025 ALNY S 90 $449.92 $40,493 23,986 Direct -0.37% Disposed -50.2% (price as of )
Aug. 18, 2025 ALNY S 39 $450.92 $17,586 23,947 Direct -0.16% Disposed -50.3% (price as of )
Aug. 18, 2025 ALNY S 103 $451.99 $46,555 23,844 Direct -0.43% Disposed -50.4% (price as of )
Aug. 18, 2025 ALNY S 329 $452.96 $149,024 23,515 Direct -1.38% Disposed -50.5% (price as of )
Aug. 18, 2025 ALNY S 543 $454.04 $246,544 22,972 Direct -2.31% Disposed -50.7% (price as of )
Aug. 18, 2025 ALNY S 241 $454.84 $109,616 22,731 Direct -1.05% Disposed -50.7% (price as of )
Aug. 18, 2025 ALNY S 12 $455.82 $5,470 22,719 Direct -0.05% Disposed -50.9% (price as of )

Loaded 100 of 180 rows

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
March 2, 2026 ALNY Stock Option (right to buy) Common Stock (8,105) $325.07 March 2, 2036 8,105 Acquired
Feb. 26, 2026 OVID Employee Stock Option (Right to Buy) Common Stock (65,000) $1.65 Feb. 25, 2036 65,000 Acquired
Nov. 17, 2025 ALNY Stock Option (right to buy) Common Stock (8,161) $119.13 March 1, 2028 8,161 Disposed
March 3, 2025 ALNY Stock Option (right to buy) Common Stock (7,819) $243.53 March 3, 2035 7,819 Acquired
Feb. 20, 2025 OVID Stock Option (right to buy) Common Stock (45,000) $0.57 Feb. 19, 2035 45,000 Acquired
Dec. 12, 2024 OVID Stock Option (Right to Buy) Common Stock (90,000) $1.06 Dec. 11, 2034 90,000 Acquired
Aug. 12, 2024 ALNY Stock Option (right to buy) Common Stock (14,058) $85.00 Feb. 28, 2029 14,058 Disposed
Aug. 12, 2024 ALNY Stock Option (right to buy) Common Stock (6,667) $97.72 Dec. 7, 2025 6,667 Disposed
Feb. 22, 2024 OVID Stock Option (Right to Buy) Common Stock (30,000) $3.68 Feb. 21, 2034 30,000 Acquired
Feb. 23, 2023 OVID Stock Option (Right to Buy) Common Stock (15,000) $2.50 Feb. 22, 2033 15,000 Acquired
Feb. 3, 2022 OVID Stock Option (Right to Buy) Common Stock (15,000) $2.72 Feb. 2, 2032 15,000 Acquired
Oct. 6, 2021 OVID Stock Option (Right to Buy) Common Stock (30,000) $3.44 Oct. 5, 2031 30,000 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 11 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
March 28, 2024 ALNY Common Stock 12,881 Direct
March 28, 2024 ALNY Common Stock 537 Indirect
March 28, 2024 ALNY Performance Stock Option 2017 (right to buy)→ Common Stock (9,000) 9,000 Direct
March 28, 2024 ALNY Stock Option (right to buy)→ Common Stock (16,250) 16,250 Direct
March 28, 2024 ALNY Stock Option (right to buy)→ Common Stock (6,667) 6,667 Direct
March 28, 2024 ALNY Stock Option (right to buy)→ Common Stock (14,580) 14,580 Direct
March 28, 2024 ALNY Stock Option (right to buy)→ Common Stock (9,000) 9,000 Direct
March 28, 2024 ALNY Stock Option (right to buy)→ Common Stock (20,382) 20,382 Direct
March 28, 2024 ALNY Stock Option (right to buy)→ Common Stock (15,692) 15,692 Direct
March 28, 2024 ALNY Stock Option (right to buy)→ Common Stock (9,279) 9,279 Direct
March 28, 2024 ALNY Stock Option (right to buy)→ Common Stock (10,352) 10,352 Direct

Holdings reported on Form 4 15 reported holdings

08

Positions listed on each Form 4 without a transaction in that filing (Table I and II holdings), newest filing first.

DateTickerSecuritySharesExercise priceExpirationOwnership
March 6, 2026 ALNY Common Stock 537 · · Indirect
March 4, 2026 ALNY Common Stock 537 · · Indirect
Feb. 25, 2026 ALNY Common Stock 537 · · Indirect
Feb. 17, 2026 ALNY Common Stock 537 · · Indirect
Jan. 14, 2026 ALNY Common Stock 537 · · Indirect
Nov. 19, 2025 ALNY Common Stock 537 · · Indirect
Oct. 3, 2025 ALNY Common Stock 537 · · Indirect
Aug. 19, 2025 ALNY Common Stock 537 · · Indirect
July 2, 2025 ALNY Common Stock 537 · · Indirect
March 5, 2025 ALNY Common Stock 537 · · Indirect
March 3, 2025 ALNY Common Stock 537 · · Indirect
Feb. 18, 2025 ALNY Common Stock 537 · · Indirect
Nov. 27, 2024 ALNY Common Stock 537 · · Indirect
Aug. 14, 2024 ALNY Common Stock 537 · · Indirect
June 26, 2024 ALNY Common Stock 537 · · Indirect

Compensation (DEF 14A)

10

Matched by name from proxy statements (DEF 14A) — verify against the filing.

ALNY

EVP
Fiscal yearSalaryBonusStock awards Option awardsNon-equity incentivePension changeOtherTotal
2024 $586,600 · · · $616,550 · $22,150 $2,673,200

Figures from the Summary Compensation Table of the company's proxy statement (DEF 14A). Compensation is not a recommendation.