O'NEIL PATRICK R.

CIK 1564926 · View on SEC EDGAR ↗

Insider

First SEC filing: March 11, 2026 · Latest: March 11, 2026

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Insider at

Insider transactions

0 buys (P) 16 sells (S) Net: $-16,034,086 + 68 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

68 other filings hidden
Date Ticker Code Shares Price Value Owned after Δ own A/D vs now
June 26, 2026 IONS S 10b5-1 3,069 $80.00 $245,520 61,470 Direct -4.76% Disposed -24.6% (price as of 2026-08-19)
March 9, 2026 IONS S 10b5-1 10,148 $75.25 $763,637 62,211 Direct -14.02% Disposed -19.8% (price as of 2026-08-19)
Jan. 30, 2026 IONS S 6,179 $83.53 $516,132 71,983 Direct -7.91% Disposed -27.8% (price as of 2026-08-19)
Jan. 16, 2026 IONS S 9,191 $75.84 $697,045 66,171 Direct -12.20% Disposed -20.4% (price as of 2026-08-19)
Oct. 6, 2025 IONS S 10b5-1 3,241 $69.27 $224,504 53,889 Direct -5.67% Disposed -12.9% (price as of 2026-08-19)
Oct. 6, 2025 IONS S 10b5-1 10,200 $69.89 $712,878 57,130 Direct -15.15% Disposed -13.7% (price as of 2026-08-19)
Oct. 2, 2025 IONS S 10b5-1 34,461 $67.69 $2,332,665 57,130 Direct -37.62% Disposed -10.9% (price as of 2026-08-19)
Oct. 2, 2025 IONS S 10b5-1 30,203 $67.69 $2,044,441 57,130 Direct -34.58% Disposed -10.9% (price as of 2026-08-19)
Sept. 30, 2025 IONS S 10b5-1 14,827 $64.68 $959,010 57,130 Direct -20.61% Disposed -6.7% (price as of 2026-08-19)
Sept. 29, 2025 IONS S 10b5-1 10,473 $64.54 $675,927 57,130 Direct -15.49% Disposed -6.5% (price as of 2026-08-19)
Sept. 12, 2025 IONS S 10b5-1 1,700 $64.58 $109,786 57,130 Direct -2.89% Disposed -6.6% (price as of 2026-08-19)
Sept. 9, 2025 IONS S 10b5-1 1,000 $64.56 $64,560 57,130 Direct -1.72% Disposed -6.5% (price as of 2026-08-19)
Sept. 9, 2025 IONS S 10b5-1 20,000 $64.56 $1,291,200 57,130 Direct -25.93% Disposed -6.5% (price as of 2026-08-19)
Sept. 3, 2025 IONS S 10b5-1 11,375 $61.42 $698,652 7,330 Direct -60.81% Disposed -1.8% (price as of 2026-08-19)
Sept. 3, 2025 IONS S 10b5-1 65,475 $60.89 $3,986,773 5,655 Direct -92.05% Disposed -0.9% (price as of 2026-08-19)
Sept. 2, 2025 IONS S 10b5-1 13,050 $54.51 $711,356 57,130 Direct -18.60% Disposed 10.7% (price as of 2026-08-19)
Feb. 20, 2025 IONS S 10b5-1 1,207 $32.35 $39,046 56,245 Direct -2.10% Disposed 86.5% (price as of 2026-08-19)
Feb. 4, 2025 IONS S 10b5-1 6,165 $31.62 $194,937 57,452 Direct -9.69% Disposed 90.8% (price as of 2026-08-19)
Jan. 31, 2025 IONS S 1,406 $32.49 $45,681 63,617 Direct -2.16% Disposed 85.7% (price as of 2026-08-19)
Jan. 16, 2025 IONS S 7,360 $32.83 $241,629 61,203 Direct -10.73% Disposed 83.8% (price as of 2026-08-19)
Feb. 2, 2024 IONS S 1,995 $49.67 $99,092 48,627 Direct -3.94% Disposed 21.5% (price as of 2026-08-19)
Feb. 2, 2024 IONS S 1,961 $49.67 $97,403 48,661 Direct -3.87% Disposed 21.5% (price as of 2026-08-19)
Jan. 25, 2024 IONS S 6,450 $51.75 $333,788 46,802 Direct -12.11% Disposed 16.6% (price as of 2026-08-19)
Jan. 17, 2024 IONS S 7,744 $50.42 $390,452 53,252 Direct -12.70% Disposed 19.7% (price as of 2026-08-19)
Dec. 26, 2023 IONS S 20,825 $51.46 $1,071,654 40,355 Direct -34.04% Disposed 17.2% (price as of 2026-08-19)
May 24, 2023 IONS S 10b5-1 1,527 $41.70 $63,676 40,355 Direct -3.65% Disposed 44.7% (price as of 2026-08-19)
Feb. 6, 2023 IONS S 1,920 $40.86 $78,451 41,581 Direct -4.41% Disposed 47.7% (price as of 2026-08-19)
Jan. 31, 2023 IONS S 10b5-1 4,500 $39.71 $178,695 39,679 Direct -10.19% Disposed 51.9% (price as of 2026-08-19)
Jan. 30, 2023 IONS S 10b5-1 4,500 $39.42 $177,390 44,179 Direct -9.24% Disposed 53.1% (price as of 2026-08-19)
Jan. 18, 2023 IONS S 7,836 $39.49 $309,444 48,679 Direct -13.87% Disposed 52.8% (price as of 2026-08-19)
April 12, 2022 IONS S 10b5-1 6,792 $40.06 $272,088 34,536 Direct -16.43% Disposed 50.6% (price as of 2026-08-19)
Jan. 25, 2021 IONS S 10b5-1 5,324 $63.50 $338,074 26,502 Direct -16.73% Disposed -5.0% (price as of 2026-08-19)

Showing latest 100 of 511 transactions

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II)

Options, RSUs and convertible securities reported on Form 4 Table II.

Date Ticker Security Underlying Exercise price Expiration Shares A/D
Jan. 15, 2026 IONS Restricted Stock Unit [F8] Common Stock (9,675) — — 9,675 Acquired
Jan. 15, 2026 IONS Restricted Stock Unit Common Stock (21,473) — — 21,473 Disposed
Jan. 15, 2026 IONS Performance Restricted Stock Units [F4] Common Stock (25,800) $0.00 — 25,800 Acquired
Jan. 2, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (19,350) $79.67 Jan. 1, 2036 19,350 Acquired
Oct. 6, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (10,200) $52.87 Jan. 1, 2034 10,200 Disposed
Oct. 2, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (34,461) $60.89 Jan. 1, 2027 34,461 Disposed
Oct. 2, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (30,203) $56.78 Jan. 3, 2028 30,203 Disposed
Sept. 30, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (14,827) $56.78 Jan. 3, 2028 14,827 Disposed
Sept. 29, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (10,473) $56.78 Jan. 3, 2028 10,473 Disposed
Sept. 12, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (1,700) $56.78 Jan. 3, 2028 1,700 Disposed
Sept. 9, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (20,000) $60.89 Jan. 1, 2027 20,000 Disposed
Sept. 9, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (1,000) $56.78 Jan. 3, 2028 1,000 Disposed
Sept. 3, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (49,800) $53.77 Jan. 1, 2026 49,800 Disposed
Sept. 3, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (14,000) $37.58 Jan. 2, 2033 14,000 Disposed
Sept. 3, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (13,050) $32.60 Jan. 2, 2032 13,050 Disposed
Sept. 2, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (13,050) $32.60 Jan. 2, 2032 13,050 Disposed
Jan. 15, 2025 IONS Restricted Stock Unit Common Stock (19,690) — — 19,690 Disposed
Jan. 15, 2025 IONS Restricted Stock Unit [F6] Common Stock (33,000) — — 33,000 Acquired
Jan. 15, 2025 IONS Performance Restricted Stock Units [F4] Common Stock (22,000) $0.00 — 22,000 Acquired
Jan. 2, 2025 IONS Non-Qualified Stock Option (right to buy) Common Stock (22,000) $34.69 Jan. 1, 2035 22,000 Acquired
Jan. 16, 2024 IONS Restricted Stock Unit Common Stock (20,641) — — 20,641 Disposed
Jan. 15, 2024 IONS Restricted Stock Unit [F3] Common Stock (20,400) — — 20,400 Acquired
Jan. 15, 2024 IONS Performance Restricted Stock Units [F1] Common Stock (17,000) $0.00 — 17,000 Acquired
Jan. 2, 2024 IONS Non-Qualified Stock Option (right to buy) Common Stock (27,200) $52.87 Jan. 1, 2034 27,200 Acquired
Dec. 26, 2023 IONS Non-Qualified Stock Option (right to buy) Common Stock (20,825) $47.34 Jan. 2, 2024 20,825 Disposed
Jan. 17, 2023 IONS Restricted Stock Unit Common Stock (21,871) — — 21,871 Disposed
Jan. 15, 2023 IONS Restricted Stock Unit [F3] Common Stock (17,207) — — 17,207 Acquired
Jan. 15, 2023 IONS Performance Restricted Stock Units [F1] Common Stock (14,338) $0.00 — 14,338 Acquired
Jan. 3, 2023 IONS Non-Qualified Stock Option (right to buy) Common Stock (22,942) $37.58 Jan. 2, 2033 22,942 Acquired
Jan. 18, 2022 IONS Restricted Stock Unit Common Stock (21,086) — — 21,086 Disposed
Jan. 15, 2022 IONS Restricted Stock Unit [F3] Common Stock (15,284) — — 15,284 Acquired
Jan. 15, 2022 IONS Performance Restricted Stock Units [F1] Common Stock (11,463) $0.00 — 11,463 Acquired
Jan. 3, 2022 IONS Non-Qualified Stock Option (right to buy) Common Stock (30,567) $32.60 Jan. 2, 2032 30,567 Acquired
Jan. 15, 2021 IONS Restricted Stock Units Common Stock (16,504) — — 16,504 Disposed
Jan. 15, 2021 IONS Restricted Stock Units Common Stock (25,868) — — 25,868 Acquired
Jan. 4, 2021 IONS Employee Stock Option (right to buy) Common Stock (58,203) $56.78 Jan. 3, 2028 58,203 Acquired
Jan. 15, 2020 IONS Restricted Stock Units Common Stock (12,045) — — 12,045 Disposed
Jan. 15, 2020 IONS Restricted Stock Units Common Stock (24,205) — — 24,205 Acquired
Jan. 2, 2020 IONS Employee Stock Option (Right to Buy) Common Stock (54,461) $60.89 Jan. 1, 2027 54,461 Acquired
April 5, 2019 IONS Employee Stock Option (right to buy) Common Stock (2,252) $61.68 Jan. 3, 2023 2,252 Acquired
April 4, 2019 IONS Employee Stock Option (right to buy) Common Stock (8,000) $49.25 Jan. 1, 2025 8,000 Acquired
April 4, 2019 IONS Employee Stock Option (right to buy) Common Stock (5,600) $47.34 Jan. 2, 2024 5,600 Acquired
April 4, 2019 IONS Employee Stock Option (right to buy) Common Stock (2,657) $61.57 Jan. 1, 2022 2,657 Acquired
April 4, 2019 IONS Employee Stock Option (right to buy) Common Stock (20,365) $61.68 Jan. 3, 2023 20,365 Acquired
April 3, 2019 IONS Employee Stock Option (right to buy) Common Stock (7,654) $61.68 Jan. 3, 2023 7,654 Acquired
March 18, 2019 IONS Employee Stock Option (right to buy) Common Stock (28,800) $61.57 Jan. 1, 2022 28,800 Acquired
Feb. 27, 2019 IONS Employee Stock Option (right to buy) Common Stock (8,000) $39.87 Jan. 1, 2021 8,000 Acquired
Feb. 27, 2019 IONS Employee Stock Option (right to buy) Common Stock (18,800) $47.34 Jan. 2, 2024 18,800 Acquired
Feb. 12, 2019 IONS Employee Stock Option (right to buy) Common Stock (275) $39.87 Jan. 1, 2021 275 Acquired
Feb. 5, 2019 IONS Employee Stock Option (right to buy) Common Stock (15,600) $39.87 Jan. 1, 2021 15,600 Acquired
Feb. 1, 2019 IONS Employee Stock Option (right to buy) Common Stock (4,000) $39.87 Jan. 1, 2021 4,000 Acquired
Jan. 15, 2019 IONS Restricted Stock Units Common Stock (7,823) — — 7,823 Disposed
Jan. 15, 2019 IONS Restricted Stock Units Common Stock (22,131) — — 22,131 Acquired
Jan. 3, 2019 IONS Employee Stock Option (right to buy) Common Stock (4,000) $39.87 Jan. 1, 2021 4,000 Disposed
Jan. 3, 2019 IONS Empoyee Stock Option (right to buy) Common Stock (400) $10.82 Jan. 1, 2020 400 Disposed
Jan. 2, 2019 IONS Employee Stock Option (right to buy) Common Stock (49,800) $53.77 Jan. 1, 2026 49,800 Acquired
March 12, 2018 IONS Employee Stock Option (right to buy) Common Stock (1,000) $10.82 Jan. 1, 2020 1,000 Disposed
Jan. 29, 2018 IONS Employee Stock Option (right to buy) Common Stock (300) $10.82 Jan. 1, 2020 300 Disposed
Jan. 29, 2018 IONS Employee Stock Option (right to buy) Common Stock (55) $10.82 Jan. 1, 2020 55 Disposed
Jan. 25, 2018 IONS Employee Stock Option (right to buy) Common Stock (645) $10.82 Jan. 1, 2020 645 Disposed
Jan. 15, 2018 IONS Restricted Stock Units Common Stock (6,663) — — 6,663 Disposed
Jan. 15, 2018 IONS Restricted Stock Units Common Stock (12,141) — — 12,141 Acquired
Jan. 2, 2018 IONS Employee Stock Option (right to buy) Common Stock (54,638) $49.25 Jan. 1, 2025 54,638 Acquired
Dec. 1, 2017 IONS Employee Stock Option (right to buy) Common Stock (1,000) $10.82 Jan. 1, 2020 1,000 Disposed
Nov. 1, 2017 IONS Employee Stock Option (right to buy) Common Stock (1,000) $10.82 Jan. 1, 2020 1,000 Disposed
Oct. 5, 2017 IONS Employee Stock Option (right to buy) Common Stock (800) $10.82 Jan. 1, 2020 800 Disposed
Oct. 5, 2017 IONS Employee Stock Option (right to buy) Common Stock (200) $7.25 Jan. 2, 2019 200 Disposed
Sept. 6, 2017 IONS Employee Stock Option (right to buy) CommonStock (800) $7.25 Jan. 2, 2019 800 Disposed
Sept. 5, 2017 IONS Employee Stock Option (right to buy) CommonStock (200) $7.25 Jan. 2, 2019 200 Disposed
June 1, 2017 IONS Employee Stock Option (right to buy) Common Stock (70) $10.82 Jan. 1, 2020 70 Disposed
May 1, 2017 IONS Employee Stock Option (right to buy) Common Stock (500) $10.82 Jan. 1, 2020 500 Disposed
April 24, 2017 IONS Employee Stock Option (right to buy) Common Stock (426) $10.82 Jan. 1, 2020 426 Disposed
April 24, 2017 IONS Employee Stock Option (right to buy) Common Stock (74) $10.82 Jan. 1, 2020 74 Disposed
March 1, 2017 IONS Employee Stock Option (right to buy) Common Stock (500) $10.82 Jan. 2, 2020 500 Disposed
Feb. 6, 2017 IONS Employee Stock Option (right to buy) Common Stock (481) $10.82 Jan. 1, 2020 481 Disposed
Feb. 6, 2017 IONS Employee Stock Option (right to buy) Common Stock (19) $7.25 Jan. 2, 2019 19 Disposed
Jan. 15, 2017 IONS Restricted Stock Units Common Stock (1,594) — — 1,594 Disposed
Jan. 15, 2017 IONS Restricted Stock Units Common Stock (1,311) — — 1,311 Disposed
Jan. 15, 2017 IONS Restricted Stock Units Common Stock (1,875) — — 1,875 Disposed
Jan. 15, 2017 IONS Restricted Stock Units Common Stock (653) — — 653 Disposed
Jan. 15, 2017 IONS Restricted Stock Units Common Stock (312) — — 312 Disposed
Jan. 15, 2017 IONS Restricted Stock Units Common Stock (7,537) — — 7,537 Acquired
Jan. 3, 2017 IONS Employee Stock Option (right to buy) Common Stock (45,225) $47.34 Jan. 2, 2024 45,225 Acquired
Dec. 5, 2016 IONS Employee Stock Option (right to buy) Common Stock (350) $10.82 Jan. 1, 2020 350 Disposed
Nov. 14, 2016 IONS Employee Stock Option (right to buy) Common Stock (806) $10.82 Jan. 1, 2020 806 Disposed
Nov. 14, 2016 IONS Employee Stock Option (right to buy) Common Stock (194) $10.82 Jan. 1, 2020 194 Disposed
April 6, 2016 IONS Employee Stock Option (right to buy) Common Stock (1,000) $10.82 Jan. 1, 2020 1,000 Disposed
March 23, 2016 IONS Employee Stock Option (right to buy) Common Stock (1,000) $10.82 Jan. 1, 2020 1,000 Disposed
Jan. 15, 2016 IONS Restricted Stock Units Common Stock (1,311) — — 1,311 Disposed
Jan. 15, 2016 IONS Restricted Stock Units Common Stock (1,875) — — 1,875 Disposed
Jan. 15, 2016 IONS Restricted Stock Units Common Stock (654) — — 654 Disposed
Jan. 15, 2016 IONS Restricted Stock Units Common Stock (312) — — 312 Disposed
Jan. 15, 2016 IONS Restricted Stock Units Common Stock (541) — — 541 Disposed
Jan. 15, 2016 IONS Restricted Stock Units Common Stock (6,373) — — 6,373 Acquired
Jan. 4, 2016 IONS Employee Stock Option (right to buy) Common Stock (848) $7.25 Jan. 2, 2019 848 Disposed
Jan. 4, 2016 IONS Employee Stock Option (right to buy) Common Stock (152) $10.82 Jan. 1, 2020 152 Disposed
Jan. 4, 2016 IONS Employee Stock Option (right to buy) Common Stock (38,240) $61.68 Jan. 3, 2023 38,240 Acquired
Dec. 1, 2015 IONS Employee Stock Option (right to buy) Common Stock (1,000) $7.25 Jan. 2, 2019 1,000 Disposed
Nov. 3, 2015 IONS Employee Stock Option (right to buy) Common Stock (1,000) $7.25 Jan. 2, 2019 1,000 Disposed
March 19, 2015 IONS Employee Stock Option (right to buy) Common Stock (13,125) $39.87 Jan. 1, 2021 13,125 Disposed

Showing latest 100 of 162 transactions

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 10 holdings

Securities held when first becoming an insider, per SEC Form 3.

Date Ticker Security Shares Ownership
Jan. 3, 2013 IONS Common Stock 2,328 Direct
Jan. 3, 2013 IONS Employee Stock Option (right to buy)→ Common Stock (1,350) 1,350 Direct
Jan. 3, 2013 IONS Employee Stock Option (right to buy)→ Common Stock (14,000) 14,000 Direct
Jan. 3, 2013 IONS Employee Stock Option (right to buy)→ Common Stock (25,000) 25,000 Direct
Jan. 3, 2013 IONS Employee Stock Option (right to buy)→ Common Stock (9,400) 9,400 Direct
Jan. 3, 2013 IONS Employee Stock Option (right to buy)→ Common Stock (17,400) 17,400 Direct
Jan. 3, 2013 IONS Employee Stock Option (right to buy)→ Common Stock (6,700) 6,700 Direct
Jan. 3, 2013 IONS Employee Stock Option (right to buy)→ Common Stock (19,000) 19,000 Direct
Jan. 3, 2013 IONS Employee Stock Option (right to buy)→ Common Stock (19,500) 19,500 Direct
Jan. 3, 2013 IONS Restricted Stock Unit→ Common Stock (2,166) 2,166 Direct