Insider at

04

Insider transactions

05
0 buys (P) 0 sells (S) Net: $0 + 22 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

No open-market trades on record; showing all filings.

DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
July 15, 2026 IONS A 3,399 · · 3,399 Direct · Acquired (price as of 2026-10-02)
June 4, 2026 IONS A 10,753 · · 10,753 Direct · Acquired (price as of 2026-10-02)
Oct. 15, 2021 IONS M 1,777 · · 10,664 Direct -14.28% Disposed (price as of 2026-10-02)
Oct. 15, 2021 IONS M 1,777 · · 14,222 Direct +14.28% Acquired (price as of 2026-10-02)
July 15, 2021 IONS M 1,778 · · 12,441 Direct -12.50% Disposed (price as of 2026-10-02)
July 15, 2021 IONS M 5,333 · · 14,219 Direct -27.28% Disposed (price as of 2026-10-02)
July 15, 2021 IONS M 1,778 · · 12,445 Direct +16.67% Acquired (price as of 2026-10-02)
July 15, 2021 IONS M 5,333 · · 10,667 Direct +99.98% Acquired (price as of 2026-10-02)
July 1, 2021 IONS A 5,333 · · 19,552 Direct +37.51% Acquired (price as of 2026-10-02)
July 1, 2021 IONS A 12,000 · · 12,000 Direct · Acquired (price as of 2026-10-02)
Oct. 15, 2020 IONS M 1,778 · · 3,554 Direct -33.35% Disposed (price as of 2026-10-02)
Oct. 15, 2020 IONS M 1,778 · · 5,334 Direct +50.00% Acquired (price as of 2026-10-02)
July 1, 2020 IONS A 12,000 · · 12,000 Direct · Acquired (price as of 2026-10-02)
July 1, 2020 IONS A 5,333 · · 5,333 Direct · Acquired (price as of 2026-10-02)
July 1, 2020 IONS M 1,778 · · 5,332 Direct -25.01% Disposed (price as of 2026-10-02)
July 1, 2020 IONS M 1,778 · · 3,556 Direct +100.00% Acquired (price as of 2026-10-02)
Oct. 15, 2019 IONS M 1,778 · · 1,778 Direct · Acquired (price as of 2026-10-02)
Oct. 15, 2019 IONS M 1,778 · · 5,332 Direct -25.01% Disposed (price as of 2026-10-02)
July 1, 2019 IONS A 16,000 · · 16,000 Direct · Acquired (price as of 2026-10-02)
July 1, 2019 IONS A 7,110 · · 7,110 Direct · Acquired (price as of 2026-10-02)
Oct. 15, 2018 IONS A 7,110 · · 7,110 Direct · Acquired (price as of 2026-10-02)
Sept. 23, 2018 IONS A 32,000 · · 32,000 Direct · Acquired (price as of 2026-10-02)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
July 15, 2026 IONS Restricted Stock Unit Common Stock (3,399) · · 3,399 Acquired
June 4, 2026 IONS Non-Qualified Stock Option (right to buy) Common Stock (10,753) $75.13 June 4, 2036 10,753 Acquired
Oct. 15, 2021 IONS Restricted Stock Unit Common Stock (1,777) · · 1,777 Disposed
July 15, 2021 IONS Restricted Stock Unit Common Stock (1,778) · · 1,778 Disposed
July 15, 2021 IONS Restricted Stock Unit Common Stock (5,333) · · 5,333 Disposed
July 1, 2021 IONS Restricted Stock Unit Common Stock (5,333) · · 5,333 Acquired
July 1, 2021 IONS Non-Qualified Stock Option (right to buy) Common Stock (12,000) $40.05 June 30, 2031 12,000 Acquired
Oct. 15, 2020 IONS Restricted Stock Units Common Stock (1,778) · · 1,778 Disposed
July 1, 2020 IONS Director Stock Option (right to buy) Common Stock (12,000) $60.20 June 30, 2030 12,000 Acquired
July 1, 2020 IONS Restricted Stock Units Common Stock (5,333) · · 5,333 Acquired
July 1, 2020 IONS Restricted Stock Units Common Stock (1,778) · · 1,778 Disposed
Oct. 15, 2019 IONS Restricted Stock Units Common Stock (1,778) · · 1,778 Disposed
July 1, 2019 IONS Director Stock Option (right to buy) Common Stock (16,000) $64.80 June 30, 2029 16,000 Acquired
July 1, 2019 IONS Restricted Stock Units Common Stock (7,110) · · 7,110 Acquired
Oct. 15, 2018 IONS Restricted Stock Units Common Stock (7,110) · · 7,110 Acquired
Sept. 23, 2018 IONS Director Stock Option (right to buy) Common Stock (32,000) $49.14 Sept. 22, 2028 32,000 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 1 holding

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Sept. 24, 2018 IONS No Securities Owned 0 Direct