Insider at

04

Insider transactions

05
0 buys (P) 53 sells (S) Net: $-5,431,153 + 12 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

12 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
March 5, 2026 ALNY S 10b5-1 654 $322.33 $210,804 20,443 Direct -3.10% Disposed -31.8% (price as of 2026-10-02)
March 5, 2026 ALNY S 10b5-1 740 $323.55 $239,427 19,703 Direct -3.62% Disposed -32.1% (price as of 2026-10-02)
March 5, 2026 ALNY S 10b5-1 510 $324.59 $165,541 19,193 Direct -2.59% Disposed -32.3% (price as of 2026-10-02)
March 5, 2026 ALNY S 10b5-1 500 $326.08 $163,040 18,693 Direct -2.61% Disposed -32.6% (price as of 2026-10-02)
March 4, 2026 ALNY S 106 $319.03 $33,817 23,300 Direct -0.45% Disposed -31.1% (price as of 2026-10-02)
March 4, 2026 ALNY S 102 $320.01 $32,641 23,198 Direct -0.44% Disposed -31.3% (price as of 2026-10-02)
March 4, 2026 ALNY S 215 $320.81 $68,974 22,983 Direct -0.93% Disposed -31.5% (price as of 2026-10-02)
March 4, 2026 ALNY S 289 $321.82 $93,006 22,694 Direct -1.26% Disposed -31.7% (price as of 2026-10-02)
March 4, 2026 ALNY S 350 $323.01 $113,054 22,344 Direct -1.54% Disposed -32.0% (price as of 2026-10-02)
March 4, 2026 ALNY S 767 $323.84 $248,385 21,577 Direct -3.43% Disposed -32.2% (price as of 2026-10-02)
March 4, 2026 ALNY S 272 $324.88 $88,367 21,305 Direct -1.26% Disposed -32.4% (price as of 2026-10-02)
March 4, 2026 ALNY S 208 $325.67 $67,739 21,097 Direct -0.98% Disposed -32.5% (price as of 2026-10-02)
March 3, 2026 ALNY S 10b5-1 355 $316.74 $112,443 24,826 Direct -1.41% Disposed -30.6% (price as of 2026-10-02)
March 3, 2026 ALNY S 10b5-1 317 $319.06 $101,142 24,509 Direct -1.28% Disposed -31.1% (price as of 2026-10-02)
March 3, 2026 ALNY S 10b5-1 640 $320.48 $205,107 23,869 Direct -2.61% Disposed -31.4% (price as of 2026-10-02)
March 3, 2026 ALNY S 10b5-1 463 $321.50 $148,854 23,406 Direct -1.94% Disposed -31.7% (price as of 2026-10-02)
March 2, 2026 ALNY S 50 $323.62 $16,181 26,848 Direct -0.19% Disposed -32.1% (price as of 2026-10-02)
March 2, 2026 ALNY S 97 $324.65 $31,491 26,751 Direct -0.36% Disposed -32.3% (price as of 2026-10-02)
March 2, 2026 ALNY S 277 $325.63 $90,200 26,474 Direct -1.04% Disposed -32.5% (price as of 2026-10-02)
March 2, 2026 ALNY S 421 $326.81 $137,587 26,053 Direct -1.59% Disposed -32.8% (price as of 2026-10-02)
March 2, 2026 ALNY S 353 $327.67 $115,668 25,700 Direct -1.35% Disposed -32.9% (price as of 2026-10-02)
March 2, 2026 ALNY S 107 $328.71 $35,172 25,593 Direct -0.42% Disposed -33.2% (price as of 2026-10-02)
March 2, 2026 ALNY S 182 $329.71 $60,007 25,411 Direct -0.71% Disposed -33.4% (price as of 2026-10-02)
March 2, 2026 ALNY S 87 $330.85 $28,784 25,324 Direct -0.34% Disposed -33.6% (price as of 2026-10-02)
March 2, 2026 ALNY S 101 $331.93 $33,525 25,223 Direct -0.40% Disposed -33.8% (price as of 2026-10-02)
March 2, 2026 ALNY S 42 $332.64 $13,971 25,181 Direct -0.17% Disposed -33.9% (price as of 2026-10-02)
Feb. 27, 2026 ALNY S 10b5-1 127 $328.92 $41,773 26,629 Direct -0.47% Disposed -33.2% (price as of 2026-10-02)
Feb. 27, 2026 ALNY S 10b5-1 2,259 $330.73 $747,119 24,370 Direct -8.48% Disposed -33.6% (price as of 2026-10-02)
Feb. 27, 2026 ALNY S 10b5-1 1,159 $331.49 $384,197 23,211 Direct -4.76% Disposed -33.7% (price as of 2026-10-02)
Feb. 27, 2026 ALNY S 10b5-1 942 $332.48 $313,196 22,269 Direct -4.06% Disposed -33.9% (price as of 2026-10-02)
Feb. 27, 2026 ALNY S 10b5-1 140 $334.39 $46,815 22,129 Direct -0.63% Disposed -34.3% (price as of 2026-10-02)
Feb. 13, 2026 ALNY S 2,242 $310.08 $695,199 24,848 Direct -8.28% Disposed -29.1% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 39 $353.95 $13,804 23,982 Direct -0.16% Disposed -37.9% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 42 $355.16 $14,917 23,940 Direct -0.18% Disposed -38.1% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 41 $356.09 $14,600 23,899 Direct -0.17% Disposed -38.3% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 96 $357.17 $34,288 23,803 Direct -0.40% Disposed -38.5% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 123 $358.18 $44,056 23,680 Direct -0.52% Disposed -38.7% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 85 $359.14 $30,527 23,595 Direct -0.36% Disposed -38.8% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 155 $360.22 $55,834 23,440 Direct -0.66% Disposed -39.0% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 98 $361.45 $35,422 23,342 Direct -0.42% Disposed -39.2% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 73 $362.38 $26,454 23,269 Direct -0.31% Disposed -39.4% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 47 $363.55 $17,087 23,222 Direct -0.20% Disposed -39.6% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 199 $364.83 $72,601 23,023 Direct -0.86% Disposed -39.8% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 220 $365.56 $80,423 22,803 Direct -0.96% Disposed -39.9% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 50 $366.41 $18,320 22,753 Direct -0.22% Disposed -40.0% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 41 $367.40 $15,063 22,712 Direct -0.18% Disposed -40.2% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 92 $368.62 $33,913 22,620 Direct -0.41% Disposed -40.4% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 40 $369.48 $14,779 22,580 Direct -0.18% Disposed -40.5% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 18 $370.87 $6,676 22,562 Direct -0.08% Disposed -40.8% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 3 $372.46 $1,117 22,559 Direct -0.01% Disposed -41.0% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 14 $374.44 $5,242 22,545 Direct -0.06% Disposed -41.3% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 19 $375.65 $7,137 22,526 Direct -0.08% Disposed -41.5% (price as of 2026-10-02)
Jan. 12, 2026 ALNY S 15 $377.82 $5,667 22,511 Direct -0.07% Disposed -41.8% (price as of 2026-10-02)
Oct. 3, 2025 ALNY S 10b5-1 682 $449.99 $306,893 22,561 Direct -2.93% Disposed -51.2% (price as of 2026-10-02)
Oct. 3, 2025 ALNY S 10b5-1 810 $450.63 $365,010 21,751 Direct -3.59% Disposed -51.2% (price as of 2026-10-02)
Oct. 3, 2025 ALNY S 10b5-1 898 $451.76 $405,680 20,853 Direct -4.13% Disposed -51.4% (price as of 2026-10-02)
Oct. 3, 2025 ALNY S 10b5-1 417 $453.51 $189,114 20,436 Direct -2.00% Disposed -51.6% (price as of 2026-10-02)
Oct. 3, 2025 ALNY S 10b5-1 215 $454.37 $97,690 20,221 Direct -1.05% Disposed -51.6% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 115 $446.53 $51,351 26,065 Direct -0.44% Disposed -50.8% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 56 $447.92 $25,084 26,009 Direct -0.21% Disposed -50.9% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 180 $448.77 $80,779 25,829 Direct -0.69% Disposed -51.0% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 249 $449.79 $111,998 25,580 Direct -0.96% Disposed -51.2% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 541 $450.81 $243,888 25,039 Direct -2.11% Disposed -51.3% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 332 $451.86 $150,018 24,707 Direct -1.33% Disposed -51.4% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 668 $452.69 $302,397 24,039 Direct -2.70% Disposed -51.5% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 329 $453.77 $149,290 23,710 Direct -1.37% Disposed -51.6% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 244 $454.84 $110,981 23,466 Direct -1.03% Disposed -51.7% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 73 $455.82 $33,275 23,393 Direct -0.31% Disposed -51.8% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 147 $457.43 $67,242 23,246 Direct -0.63% Disposed -52.0% (price as of 2026-10-02)
Oct. 2, 2025 ALNY S 3 $457.64 $1,373 23,243 Direct -0.01% Disposed -52.0% (price as of 2026-10-02)
Aug. 19, 2025 ALNY S 10b5-1 276 $455.41 $125,693 21,400 Direct -1.27% Disposed -51.8% (price as of 2026-10-02)
Aug. 19, 2025 ALNY S 10b5-1 338 $457.26 $154,554 21,062 Direct -1.58% Disposed -51.9% (price as of 2026-10-02)
Aug. 19, 2025 ALNY S 10b5-1 231 $458.27 $105,860 20,831 Direct -1.10% Disposed -52.1% (price as of 2026-10-02)
Aug. 19, 2025 ALNY S 10b5-1 260 $459.59 $119,493 20,571 Direct -1.25% Disposed -52.2% (price as of 2026-10-02)
Aug. 19, 2025 ALNY S 10b5-1 305 $461.01 $140,608 20,266 Direct -1.48% Disposed -52.3% (price as of 2026-10-02)
Aug. 19, 2025 ALNY S 10b5-1 45 $461.74 $20,778 20,221 Direct -0.22% Disposed -52.4% (price as of 2026-10-02)
Aug. 18, 2025 ALNY S 39 $447.98 $17,471 23,033 Direct -0.17% Disposed -51.0% (price as of 2026-10-02)
Aug. 18, 2025 ALNY S 90 $449.92 $40,493 22,943 Direct -0.39% Disposed -51.2% (price as of 2026-10-02)
Aug. 18, 2025 ALNY S 39 $450.92 $17,586 22,904 Direct -0.17% Disposed -51.3% (price as of 2026-10-02)
Aug. 18, 2025 ALNY S 103 $451.99 $46,555 22,801 Direct -0.45% Disposed -51.4% (price as of 2026-10-02)
Aug. 18, 2025 ALNY S 329 $452.96 $149,024 22,472 Direct -1.44% Disposed -51.5% (price as of 2026-10-02)
Aug. 18, 2025 ALNY S 543 $454.04 $246,544 21,929 Direct -2.42% Disposed -51.6% (price as of 2026-10-02)
Aug. 18, 2025 ALNY S 241 $454.84 $109,616 21,688 Direct -1.10% Disposed -51.7% (price as of 2026-10-02)
Aug. 18, 2025 ALNY S 12 $455.82 $5,470 21,676 Direct -0.06% Disposed -51.8% (price as of 2026-10-02)
March 24, 2025 ALNY S 10b5-1 5,445 $300.00 $1,633,500 20,221 Direct -21.21% Disposed -26.8% (price as of 2026-10-02)
March 21, 2025 ALNY S 10b5-1 4,321 $285.00 $1,231,485 20,221 Direct -17.61% Disposed -22.9% (price as of 2026-10-02)
March 3, 2025 ALNY S 213 $242.37 $51,625 26,886 Direct -0.79% Disposed -9.3% (price as of 2026-10-02)
March 3, 2025 ALNY S 235 $243.36 $57,190 26,651 Direct -0.87% Disposed -9.7% (price as of 2026-10-02)

Showing latest 100 of 225 transactions

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
March 2, 2026 ALNY Stock Option (right to buy) Common Stock (10,480) $325.07 March 2, 2036 10,480 Acquired
Feb. 27, 2026 ALNY Restricted Stock Units Common Stock (1,908) · · 1,908 Disposed
March 24, 2025 ALNY Stock Option (right to buy) Common Stock (5,445) $42.22 Dec. 20, 2026 5,445 Disposed
March 3, 2025 ALNY Stock Option (right to buy) Common Stock (7,819) $243.53 March 3, 2035 7,819 Acquired
Feb. 27, 2025 ALNY Restricted Stock Units Common Stock (1,908) · · 1,908 Disposed
Jan. 27, 2025 ALNY Performance Stock Option 2015 (right to buy) Common Stock (25,000) $88.95 Dec. 18, 2025 25,000 Disposed
Jan. 27, 2025 ALNY Stock Option (right to buy) Common Stock (23,876) $88.95 Dec. 18, 2025 23,876 Disposed
March 1, 2024 ALNY Stock Option (right to buy) Common Stock (9,279) $152.61 March 1, 2034 9,279 Acquired
Feb. 27, 2024 ALNY Restricted Stock Units Common Stock (1,908) · · 1,908 Disposed
March 3, 2023 ALNY Performance Stock Option 2014 (right to buy) Common Stock (2,500) $96.45 Dec. 17, 2024 2,500 Disposed
March 3, 2023 ALNY Stock Option (right to buy) Common Stock (2,500) $96.45 Dec. 17, 2024 2,500 Disposed
Feb. 27, 2023 ALNY Restricted Stock Units Common Stock (5,724) · Feb. 27, 2026 5,724 Acquired
Feb. 27, 2023 ALNY Stock Option (right to buy) Common Stock (11,850) $190.01 Feb. 27, 2033 11,850 Acquired
Feb. 23, 2022 ALNY Stock Option (right to buy) Common Stock (24,128) $147.47 Feb. 22, 2032 24,128 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 14 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Jan. 4, 2022 ALNY Common Stock 11,192 Direct
Jan. 4, 2022 ALNY Common Stock 431 Indirect
Jan. 4, 2022 ALNY Common Stock 250 Indirect
Jan. 4, 2022 ALNY Performance Stock Option 2014 (right to buy)→ Common Stock (2,500) 2,500 Direct
Jan. 4, 2022 ALNY Performance Stock Option 2015 (right to buy)→ Common Stock (25,000) 25,000 Direct
Jan. 4, 2022 ALNY Performance Stock Option 2017 (right to buy)→ Common Stock (13,750) 13,750 Direct
Jan. 4, 2022 ALNY Stock Option (right to buy)→ Common Stock (5,445) 5,445 Direct
Jan. 4, 2022 ALNY Stock Option (right to buy)→ Common Stock (25,000) 25,000 Direct
Jan. 4, 2022 ALNY Stock Option (right to buy)→ Common Stock (23,876) 23,876 Direct
Jan. 4, 2022 ALNY Stock Option (right to buy)→ Common Stock (2,500) 2,500 Direct
Jan. 4, 2022 ALNY Stock Option (right to buy)→ Common Stock (26,089) 26,089 Direct
Jan. 4, 2022 ALNY Stock Option (right to buy)→ Common Stock (13,750) 13,750 Direct
Jan. 4, 2022 ALNY Stock Option (right to buy)→ Common Stock (23,200) 23,200 Direct
Jan. 4, 2022 ALNY Stock Option (right to buy)→ Common Stock (13,428) 13,428 Direct

Compensation (DEF 14A)

08

Matched by name from proxy statements (DEF 14A) — verify against the filing.

ALNY

EVP
Fiscal yearSalaryBonusStock awards Option awardsNon-equity incentivePension changeOtherTotal
2025 $767,900 · · · $1,072,500 · $22,400 $6,490,500
2024 $682,100 · · · $716,870 · $22,150 $2,919,190
2023 $656,900 · · $1,085,590 $382,880 · $18,100 $3,231,090

Figures from the Summary Compensation Table of the company's proxy statement (DEF 14A). Compensation is not a recommendation.