SEPN Septerna, Inc. - Common Stock
SEPN Aperçu de l'action Prix, capitalisation boursière, P/E, EPS, ROE, dette/capitaux propres, fourchette sur 52 semaines
SEPN Graphique du cours de l'action OHLCV quotidien avec indicateurs techniques — panoramique, zoom et personnalisez votre vue
Performance sur 10 ans Tendances du chiffre d'affaires, du bénéfice net, des marges et du BPA
Valorisation Ratios P/E, P/S, P/B, EV/EBITDA — l'action est-elle chère ou bon marché ?
Rentabilité Marges brutes, d'exploitation et nettes ; ROE, ROA, ROIC
Santé financière Dette, liquidité, solvabilité — solidité du bilan
Croissance Croissance du chiffre d'affaires, du BPA et du bénéfice net : Année/Année, TCAC 3 ans, TCAC 5 ans
Efficacité du capital Rotation des actifs, rotation des stocks, rotation des créances
SEPN Consensus des analystes Opinions des analystes haussières et baissières, objectif de cours à 12 mois, potentiel de hausse
- Achat fort 5 31,2%
- Achat 10 62,5%
- Conserver 1 6,2%
- Vente 0 0,0%
- Vente forte 0 0,0%
Objectif de cours à 12 mois
9 analystes · 2026-08-24Historique des bénéfices BPA réel vs estimation, surprise %, taux de succès, prochaine date de publication des résultats
| Période | EPS Actual | BPA est. | Surprise |
|---|---|---|---|
| 30 juin 2026 | $-0.29 | $-0.43 | 0.14% |
| 31 mars 2026 | $-0.19 | $-0.42 | 0.23% |
| 31 décembre 2025 | $-0.24 | $-0.26 | 0.02% |
| 30 septembre 2025 | $-0.09 | $0.81 | -0.90% |
| 30 juin 2025 | $-0.56 | $0.88 | -1.4% |
| 31 mars 2025 | $-0.49 | $-0.46 | -0.03% |
Comparaison des pairs (sous-secteur GICS) Indicateurs clés par rapport aux pairs du secteur
| Ticker | Capitalisation Boursière | P/E | Revenus Année/Année | Marge Nette | ROE | Marge Brute |
|---|---|---|---|---|---|---|
| SEPN | $1.25B | -25.3 | 4174.5% | -106.4% | -12.9% | — |
| RAPP | $1.45B | -10.6 | — | — | -29.8% | — |
| HRMY | $2.16B | 13.8 | 21.5% | 18.3% | 19.3% | 77.2% |
| TRLV | — | — | -0.45% | -10.3% | -10.4% | 60.2% |
| KARD | — | — | — | — | — | — |
| ETON | $457M | — | 104.9% | -5.8% | -18.4% | 53.5% |
| ANIP | $1.78B | 23.8 | 43.8% | 8.9% | 16.6% | — |
| AVLN | — | — | — | — | — | — |
| MAZE | $2.04B | -13.6 | — | — | -598.9% | — |
| HROW | $1.82B | -350.0 | 36.4% | -1.9% | -8.4% | 75.0% |
Fondamentaux complets Tous les indicateurs par an — compte de résultat, bilan, flux de trésorerie
Compte de résultat 15
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue | $46M | $1M | $151.0K | |
| R&D Expense | $98M | $65M | $36M | |
| SG&A Expense | $29M | $17M | $10M | |
| Operating Expenses | $114M | $82M | $-2M | |
| Operating Income | $-68M | $-81M | $2M | |
| Interest Income | $20M | $9M | $3M | |
| Other Non-op | $-100.0K | $-90.0K | $10.0K | |
| Pretax Income | $-49M | $-72M | $-49M | |
| Income Tax | $12.0K | $-498.0K | $691.0K | |
| Net Income | $-49M | $-72M | $4M | |
| EPS (Basic) | $-1.10 | $-7.26 | $0.29 | |
| EPS (Diluted) | $-1.10 | $-7.26 | $0.29 | |
| Shares (Basic) | 44,258,338 | 9,891,126 | 1,928,586 | |
| Shares (Diluted) | 44,258,338 | 9,891,126 | 2,177,124 | |
| EBITDA | $-67M | $-79M | · |
Bilan 23
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Cash & Equivalents | $121M | $238M | $88M | |
| Short-term Investments | $270M | $113M | $0 | |
| Receivables | $10M | $171.0K | $151.0K | |
| Prepaid Expense | $10M | $6M | $1M | |
| Other Current Assets | $1M | $239.0K | $92.0K | |
| Current Assets | $411M | $357M | $113M | |
| PP&E (Net) | $4M | $5M | $5M | |
| PP&E (Gross) | $9M | $8M | $6M | |
| Accum. Depreciation | $4M | $3M | $2M | |
| Other Non-current Assets | $816.0K | $267.0K | $97.0K | |
| Total Assets | $596M | $457M | $131M | |
| Accounts Payable | $10M | $3M | $3M | |
| Accrued Liabilities | $12M | $8M | $4M | |
| Current Liabilities | $87M | $13M | $7M | |
| Capital Leases | $21M | $24M | $13M | |
| Other Non-current Liabilities | $0 | $33.0K | $546.0K | |
| Total Liabilities | $214M | $37M | $20M | |
| Common Stock | $45.0K | $44.0K | $3.0K | |
| Retained Earnings | $-167M | $-118M | $-47M | |
| AOCI | $617.0K | $56.0K | $0 | |
| Stockholders' Equity | $382M | $420M | $-38M | |
| Liabilities + Equity | $596M | $457M | $131M | |
| Shares Outstanding | 44,806,272 | 44,422,505 | 3,168,134 |
Flux de trésorerie 11
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| D&A | $2M | $1M | $800.0K | |
| Stock-based Comp | $8M | $3M | $2M | |
| Deferred Tax | $0 | $-491.0K | $491.0K | |
| Other Non-cash | $149M | $267.0K | · | |
| Operating Cash Flow | $110M | $-67M | $-39M | |
| CapEx | $518.0K | $2M | $3M | |
| Investing Cash Flow | $-229M | $-161M | $22M | |
| Financing Cash Flow | $2M | $378M | $75M | |
| Net Change in Cash | $-117M | $150M | $58M | |
| Taxes Paid | $0 | $232.0K | $75.0K | |
| Free Cash Flow | $110M | $-70M | · |
Rentabilité 7
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Operating Margin | -148.6% | -7518.4% | · | |
| Net Margin | -106.4% | -6678.9% | · | |
| Pretax Margin | -106.3% | -6725.2% | · | |
| EBITDA Margin | -145.2% | -7388.2% | · | |
| ROA | -9.3% | -24.4% | · | |
| ROE | -12.9% | -43.2% | · | |
| ROIC | -17.9% | -19.1% | · |
Liquidité et Solvabilité 2
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Current Ratio | 4.7 | 27.8 | · | |
| Quick Ratio | 4.6 | 27.3 | · |
Efficacité 2
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Asset Turnover | 0.1 | 0.0 | · | |
| Receivables Turnover | 8.7 | 6.7 | · |
Taux de croissance 1
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue YoY | 4174.5% | 611.9% | · |
Valorisation (TTM) 10
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue TTM | $46M | $1M | · | |
| Net Income TTM | $-49M | $-72M | · | |
| Market Cap | $1.25B | $1.02B | · | |
| P/E | -25.3 | -3.2 | · | |
| P/S | 27.2 | 946.3 | · | |
| P/B | 3.3 | 2.4 | · | |
| P / Tangible Book | 3.3 | 2.4 | · | |
| P / Cash Flow | 11.3 | -15.1 | · | |
| P / FCF | 11.4 | -14.6 | · | |
| Earnings Yield | -4.0% | -31.7% | · |
Compte de résultat 15
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $27M | $27M | $24M | $21M | $119.0K | $219.0K | $212.0K | $176.0K | $370.0K | $317.0K | |
| R&D Expense | $35M | $30M | $32M | $24M | $22M | $19M | $19M | $18M | $15M | $13M | |
| SG&A Expense | $8M | $10M | $8M | $7M | $7M | $7M | $6M | $5M | $3M | $3M | |
| Operating Expenses | $44M | $40M | $40M | $19M | $29M | $26M | $25M | $23M | $18M | $16M | |
| Operating Income | $-17M | $-13M | $-16M | $3M | $-29M | $-26M | $-25M | $-23M | $-18M | $-15M | |
| Interest Income | $5M | $5M | $5M | $6M | $4M | $4M | $4M | $2M | $2M | $1M | |
| Other Non-op | $-23.0K | $-31.0K | $-41.0K | $-6.0K | $-25.0K | $-28.0K | $-18.0K | $-9.0K | $-15.0K | $-48.0K | |
| Pretax Income | $-12M | $-8M | $-11M | $8M | $-25M | $-21M | $-21M | $-21M | $-17M | $-14M | |
| Income Tax | $973.0K | $337.0K | $12.0K | $0 | $0 | $0 | $-564.0K | $-136.0K | $109.0K | $93.0K | |
| Net Income | $-13M | $-9M | $-11M | $8M | $-25M | $-21M | $-21M | $-21M | $-17M | $-14M | |
| EPS (Basic) | $-0.29 | $-0.19 | $-0.23 | $0.18 | $-0.56 | $-0.49 | $14.52 | $-8.40 | $-7.03 | $-6.35 | |
| EPS (Diluted) | $-0.29 | $-0.19 | $-0.23 | $0.18 | $-0.56 | $-0.49 | $14.52 | $-8.40 | $-7.03 | $-6.35 | |
| Shares (Basic) | 45,040,075 | 44,758,800 | -88,187,325 | 44,343,085 | 44,165,168 | 43,937,410 | 2,877,617 | 2,443,678 | 2,337,585 | 2,232,246 | |
| Shares (Diluted) | 45,040,075 | 44,758,800 | -89,446,339 | 45,602,099 | 44,165,168 | 43,937,410 | 2,877,617 | 2,443,678 | 2,337,585 | 2,232,246 | |
| EBITDA | $-16M | $-13M | · | $3M | $-29M | $-26M | · | $-22M | · | · |
Bilan 23
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $85M | $72M | $121M | $320M | $189M | $210M | $238M | $88M | · | · | |
| Short-term Investments | $288M | $276M | $270M | $154M | $137M | $126M | $113M | $42M | · | · | |
| Receivables | $12M | $11M | $10M | $9M | $151.0K | $250.0K | $171.0K | $210.0K | · | · | |
| Prepaid Expense | $12M | $10M | $10M | $9M | $7M | $6M | $6M | $3M | · | · | |
| Other Current Assets | $133.0K | $110.0K | $1M | $387.0K | $0 | $52.0K | $239.0K | $241.0K | · | · | |
| Current Assets | $396M | $368M | $411M | $492M | $334M | $342M | $357M | $133M | · | · | |
| PP&E (Net) | $4M | $4M | $4M | $4M | $5M | $5M | $5M | $5M | · | · | |
| PP&E (Gross) | $9M | $9M | $9M | $8M | $8M | $8M | $8M | $8M | · | · | |
| Accum. Depreciation | $5M | $5M | $4M | $4M | $4M | $3M | $3M | $3M | · | · | |
| Other Non-current Assets | $1M | $773.0K | $816.0K | $501.0K | $300.0K | $277.0K | $267.0K | $3M | · | · | |
| Total Assets | $567M | $570M | $596M | $607M | $415M | $434M | $457M | $174M | · | · | |
| Accounts Payable | $4M | $7M | $10M | $4M | $7M | $4M | $3M | $6M | · | · | |
| Accrued Liabilities | $13M | $9M | $12M | $8M | $7M | $4M | $8M | $6M | · | · | |
| Current Liabilities | $79M | $78M | $87M | $75M | $15M | $11M | $13M | $13M | · | · | |
| Capital Leases | $20M | $21M | $21M | $22M | $23M | $23M | $24M | $24M | · | · | |
| Other Non-current Liabilities | $521.0K | $100.0K | $0 | $0 | $2.0K | $27.0K | $33.0K | $191.0K | · | · | |
| Total Liabilities | $180M | $191M | $214M | $218M | $38M | $34M | $37M | $38M | · | · | |
| Common Stock | $46.0K | $45.0K | $45.0K | $45.0K | $45.0K | $44.0K | $44.0K | $3.0K | · | · | |
| Retained Earnings | $-189M | $-176M | $-167M | $-157M | $-165M | $-140M | $-118M | $-98M | · | · | |
| AOCI | $-1M | $-569.0K | $617.0K | $375.0K | $176.0K | $198.0K | $56.0K | $176.0K | · | · | |
| Stockholders' Equity | $387M | $378M | $382M | $389M | $378M | $400M | $420M | $-87M | · | · | |
| Liabilities + Equity | $567M | $570M | $596M | $607M | $415M | $434M | $457M | $174M | · | · | |
| Shares Outstanding | 45,667,490 | 44,916,572 | 44,806,272 | 44,638,703 | 44,567,891 | 44,448,435 | 44,422,505 | · | · | · |
Flux de trésorerie 11
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $300.0K | $300.0K | |
| Stock-based Comp | $5M | $6M | $3M | $3M | $2M | $1M | $1M | $683.0K | $628.0K | $577.0K | |
| Deferred Tax | · | · | · | · | · | · | $-153.0K | $-136.0K | $-109.0K | $-93.0K | |
| Other Non-cash | · | $-23M | · | · | · | $-4M | · | · | · | · | |
| Operating Cash Flow | $-22M | $-26M | $-15M | $169M | $-20M | $-23M | $-21M | $-17M | $-13M | $-17M | |
| CapEx | $0 | $832.0K | $65.0K | $13.0K | $58.0K | $382.0K | $612.0K | $578.0K | $149.0K | $764.0K | |
| Investing Cash Flow | $18M | $-24M | $-185M | $-38M | $-786.0K | $-5M | $-133M | $-25M | $-12M | $10M | |
| Financing Cash Flow | $17M | $333.0K | $1M | $263.0K | $339.0K | $66.0K | $304M | $-1M | · | · | |
| Net Change in Cash | $13M | $-49M | $-199M | $131M | $-21M | $-28M | $150M | $-43M | $50M | $-7M | |
| Taxes Paid | · | · | · | · | · | · | $0 | $75.0K | · | · | |
| Free Cash Flow | · | $-26M | · | · | · | $-24M | · | · | · | · |
Rentabilité 7
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -62.9% | -50.1% | · | 12.2% | -24351.3% | -11831.1% | · | -12812.5% | · | · | |
| Net Margin | -48.7% | -32.6% | · | 38.0% | -20872.3% | -9806.4% | · | -11660.8% | · | · | |
| Pretax Margin | -45.1% | -31.3% | · | 38.0% | -20872.3% | -9806.4% | · | -11738.1% | · | · | |
| EBITDA Margin | -61.5% | -48.6% | · | 14.0% | -24015.1% | -11648.4% | · | -12585.2% | · | · | |
| ROA | -2.6% | -1.7% | · | 2.1% | -12.0% | -9.9% | · | -23.5% | · | · | |
| ROE | -3.4% | -2.2% | · | 5.4% | -13.2% | -10.7% | · | 47.0% | · | · | |
| ROIC | -4.7% | -3.7% | · | 0.67% | -7.7% | -6.5% | · | 25.6% | · | · |
Liquidité et Solvabilité 2
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 5.0 | 4.7 | · | 6.5 | 22.1 | 32.2 | · | 10.1 | · | · | |
| Quick Ratio | 4.8 | 4.6 | · | 6.4 | 21.6 | 31.6 | · | 9.9 | · | · |
Efficacité 2
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.1 | 0.1 | · | 0.1 | 0.0 | 0.0 | · | 0.0 | · | · | |
| Receivables Turnover | 4.3 | 4.8 | · | 4.9 | 1.6 | 1.8 | · | 1.7 | · | · |
Valorisation (TTM) 10
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $75M | $48M | · | $22M | $884.0K | $1M | · | $896.0K | · | · | |
| Net Income TTM | $-38M | $-47M | · | $-59M | $-83M | $-73M | · | $-62M | · | · | |
| Market Cap | $1.53B | $1.08B | · | $840M | $471M | $257M | · | · | · | · | |
| P/E | -38.9 | -22.7 | · | -2.0 | -0.6 | -0.3 | · | · | · | · | |
| P/S | 20.4 | 22.3 | · | 38.2 | 532.9 | 237.9 | · | · | · | · | |
| P/B | 4.0 | 2.9 | · | 2.2 | 1.2 | 0.6 | · | · | · | · | |
| P / Tangible Book | 4.0 | 2.9 | · | 2.2 | 1.2 | 0.6 | · | · | · | · | |
| P / Cash Flow | · | -42.1 | · | · | · | -11.0 | · | · | · | · | |
| P / FCF | · | -40.8 | · | · | · | -10.8 | · | · | · | · | |
| Earnings Yield | -2.6% | -4.4% | · | -49.3% | -155.9% | -384.6% | · | · | · | · |
États financiers Compte de résultat, bilan, flux de trésorerie — annuel, sur les 5 dernières années
Compte de résultat
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Revenu | $46M | $1M | $151.0K |
| Marge d'exploitation % | -148.6% | -7518.4% | — |
| Résultat net | $-49M | $-72M | $4M |
| BPA dilué | $-1.10 | $-7.26 | $0.29 |
Bilan
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Ratio de liquidité | 4.7 | 27.8 | — |
| Ratio de liquidité réduite | 4.6 | 27.3 | — |
Flux de trésorerie
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Flux de trésorerie libre | $110M | $-70M | — |
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Détenteurs institutionnels (13F) 169 déclarants · $1.5B total · Au 30 juin 2026
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Nouvelles positions | Positions clôturées | Augmenté | Diminué | Variation nette des actions |
|---|---|---|---|---|
| 55 (+25 vs T. préc.) | 15 (-7 vs T. préc.) | 46 (+6 vs T. préc.) | 33 (+4 vs T. préc.) | +1.2M |
Comparé à Q1 2026. Les dépôts de formulaire 13F de la SEC sont dus dans les 45 jours suivant la fin du trimestre, plus une courte période tampon pour les déposants tardifs — les trimestres encore dans cette fenêtre sont ignorés au profit de la paire la plus récente entièrement déclarée.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $234 291 284 | 6 995 858 | 15,96% | Actions |
| TRV GP V, LLC | $208 160 143 | 6 215 591 | 14,18% | Actions |
| Driehaus Capital Management LLC | $148 463 112 | 4 433 058 | 10,11% | Actions |
| TRV GP VI, LLC | $141 048 460 | 4 211 659 | 9,61% | Actions |
| SAMSARA BIOCAPITAL, LLC | $105 464 297 | 3 149 128 | 7,18% | Actions |
| Siren, L.L.C. | $63 631 000 | 1 900 000 | 4,33% | Actions |
| GOLDMAN SACHS GROUP INC | $57 564 688 | 1 718 862 | 3,92% | Actions |
| Avoro Capital Advisors LLC | $44 792 875 | 1 337 500 | 3,05% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $40 913 829 | 1 221 673 | 2,79% | Actions |
| PRIMECAP MANAGEMENT CO/CA/ | $39 095 624 | 1 167 382 | 2,66% | Actions |
| First Light Asset Management, LLC | $32 259 577 | 963 260 | 2,20% | Actions |
| ADAR1 Capital Management, LLC | $31 505 617 | 940 747 | 2,15% | Actions |
| STATE STREET CORP | $21 856 579 | 652 630 | 1,49% | Actions |
| JANUS HENDERSON GROUP PLC | $21 333 558 | 890 754 | 1,45% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $19 943 040 | 595 346 | 1,36% | Actions |
| Casdin Capital, LLC | $18 528 945 | 553 268 | 1,26% | Actions |
| Catalio Capital Management, LP | $17 955 730 | 536 152 | 1,22% | Actions |
| LOOMIS SAYLES & CO L P | $17 416 173 | 520 041 | 1,19% | Actions |
| Caption Management, LLC | $14 735 600 | 440 000 | 1,00% | Option d'achat |
| ALGERT GLOBAL LLC | $13 311 840 | 397 487 | 0,91% | Actions |
| Balyasny Asset Management L.P. | $11 736 303 | 350 442 | 0,80% | Actions |
| Longaeva Partners L.P. | $9 985 747 | 298 171 | 0,68% | Actions |
| Soleus Capital Management, L.P. | $9 209 750 | 275 000 | 0,63% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8 774 380 | 262 000 | 0,60% | Option d'achat |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $7 708 862 | 230 184 | 0,52% | Actions |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $7 458 290 | 222 702 | 0,51% | Actions |
| TWO SIGMA INVESTMENTS, LP | $7 397 439 | 220 885 | 0,50% | Actions |
| TUDOR INVESTMENT CORP ET AL | $6 698 000 | 200 000 | 0,46% | Option d'achat |
| Caption Management, LLC | $6 698 000 | 200 000 | 0,46% | Option de vente |
| Kalehua Capital Management LLC | $6 515 279 | 194 544 | 0,44% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6 264 003 | 187 041 | 0,43% | Actions |
| Woodline Partners LP | $6 213 567 | 185 535 | 0,42% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $5 547 819 | 165 656 | 0,38% | Actions |
| VANGUARD GROUP INC | $4 171 991 | 149 641 | 0,28% | Actions |
| TUDOR INVESTMENT CORP ET AL | $3 349 000 | 100 000 | 0,23% | Option de vente |
| CITADEL ADVISORS LLC | $2 739 482 | 81 800 | 0,19% | Option d'achat |
| UBS Group AG | $2 551 067 | 76 174 | 0,17% | Actions |
| LAZARD ASSET MANAGEMENT LLC | $2 525 983 | 75 425 | 0,17% | Actions |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2 499 995 | 74 649 | 0,17% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $2 284 319 | 68 209 | 0,16% | Actions |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2 283 348 | 68 180 | 0,16% | Actions |
| HUSSMAN STRATEGIC ADVISORS, INC. | $2 109 870 | 63 000 | 0,14% | Actions |
| AMERICAN CENTURY COMPANIES INC | $2 041 986 | 60 973 | 0,14% | Actions |
| DIADEMA PARTNERS LP | $1 999 353 | 59 700 | 0,14% | Option de vente |
| JANE STREET GROUP, LLC | $1 915 628 | 57 200 | 0,13% | Option d'achat |
| XTX Topco Ltd | $1 824 837 | 54 489 | 0,12% | Actions |
| MILLENNIUM MANAGEMENT LLC | $1 693 321 | 50 562 | 0,12% | Actions |
| Elmind Capital, LP | $1 655 880 | 49 444 | 0,11% | Actions |
| BARCLAYS PLC | $1 647 541 | 49 195 | 0,11% | Actions |
| Sofinnova Investments, Inc. | $1 590 976 | 47 506 | 0,11% | Actions |
| D. E. Shaw & Co., Inc. | $1 556 716 | 46 483 | 0,11% | Actions |
| Voleon Capital Management LP | $1 488 128 | 44 435 | 0,10% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $1 387 122 | 41 419 | 0,09% | Actions |
| Caption Management, LLC | $1 272 821 | 38 006 | 0,09% | Actions |
| BANK OF AMERICA CORP /DE/ | $1 201 453 | 35 875 | 0,08% | Actions |
| Alyeska Investment Group, L.P. | $1 172 150 | 35 000 | 0,08% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 135 311 | 33 900 | 0,08% | Option de vente |
| Brevan Howard Capital Management LP | $986 347 | 29 452 | 0,07% | Actions |
| HighVista Strategies LLC | $982 496 | 29 337 | 0,07% | Actions |
| TUDOR INVESTMENT CORP ET AL | $970 071 | 28 966 | 0,07% | Actions |
| RHUMBLINE ADVISERS | $925 521 | 27 636 | 0,06% | Actions |
| JANE STREET GROUP, LLC | $871 946 | 26 036 | 0,06% | Actions |
| Trexquant Investment LP | $858 851 | 25 645 | 0,06% | Actions |
| Logos Global Management LP | $788 623 | 23 548 | 0,05% | Actions |
| FMR LLC | $778 308 | 23 240 | 0,05% | Actions |
| FOX RUN MANAGEMENT, L.L.C. | $738 053 | 22 038 | 0,05% | Actions |
| ALLIANCEBERNSTEIN L.P. | $718 497 | 29 900 | 0,05% | Actions |
| TWO SIGMA ADVISERS, LP | $716 516 | 25 700 | 0,05% | Actions |
| Squarepoint Ops LLC | $710 624 | 21 219 | 0,05% | Actions |
| STRS OHIO | $703 290 | 21 000 | 0,05% | Actions |
| FRED ALGER MANAGEMENT, LLC | $701 883 | 20 958 | 0,05% | Actions |
| Jump Financial, LLC | $676 498 | 20 200 | 0,05% | Actions |
| Swiss National Bank | $663 102 | 19 800 | 0,05% | Actions |
| WELLS FARGO & COMPANY/MN | $657 677 | 19 638 | 0,04% | Actions |
| Aquatic Capital Management LLC | $583 630 | 17 427 | 0,04% | Actions |
| BlackRock, Inc. | $582 626 | 17 397 | 0,04% | Actions |
| Engineers Gate Manager LP | $581 052 | 17 350 | 0,04% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $567 522 | 16 946 | 0,04% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $555 833 | 16 597 | 0,04% | Actions |
| CITIGROUP INC | $553 623 | 16 531 | 0,04% | Actions |
| Nuveen Asset Management, LLC | $548 707 | 23 961 | 0,04% | Actions |
| State of Wyoming | $548 533 | 16 379 | 0,04% | Actions |
| Vanguard Global Advisers, LLC | $544 112 | 16 247 | 0,04% | Actions |
| Bank of New York Mellon Corp | $516 650 | 15 427 | 0,04% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $510 421 | 15 241 | 0,03% | Actions |
| Verdad Advisers, LP | $434 365 | 12 970 | 0,03% | Actions |
| MetLife Investment Management, LLC | $431 351 | 12 880 | 0,03% | Actions |
| Man Group plc | $384 097 | 11 469 | 0,03% | Actions |
| FEDERATED HERMES, INC. | $368 055 | 10 990 | 0,03% | Actions |
| China Universal Asset Management Co., Ltd. | $360 821 | 10 774 | 0,02% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $341 364 | 10 193 | 0,02% | Actions |
| Gotham Asset Management, LLC | $312 194 | 9 322 | 0,02% | Actions |
| Virtus Investment Advisers, LLC | $304 826 | 9 102 | 0,02% | Actions |
| CANADA PENSION PLAN INVESTMENT BOARD | $298 061 | 8 900 | 0,02% | Actions |
| Invesco Ltd. | $285 737 | 8 532 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $284 665 | 8 500 | 0,02% | Actions |
| FIRST TRUST ADVISORS LP | $259 179 | 7 739 | 0,02% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $248 496 | 7 420 | 0,02% | Actions |
| Quantinno Capital Management LP | $245 482 | 7 330 | 0,02% | Actions |
| Rangeley Capital, LLC | $241 128 | 7 200 | 0,02% | Actions |
Initiés de la société 15 initiés · 6 dirigeants · 8 administrateurs
| Dirigeant | Rôle | Dernière activité | Actions détenues | Achats 12m | Ventes 12m | Net 12m |
|---|---|---|---|---|---|---|
| Jeffrey Finer | Chief Executive Officer | 6 février 2026 A | 826 907 | 0 | 0 | $0 |
| Gil M Labrucherie | Chief Financial Officer | 6 février 2026 A | 40 000 | 0 | 0 | $0 |
| Samira Shaikhly | Chief People Officer | 29 juin 2026 M | 793 | 0 | 8 | $-2 802 156 |
| Uwe Klein | SVP, Biological Sciences | 6 février 2026 A | 23 008 | 0 | 0 | $0 |
| Jae B. Kim | Chief Medical Officer | 6 février 2026 A | — | 0 | 0 | $0 |
| Mark Andrew Wilson | Chief Legal Officer | 6 février 2026 A | — | 0 | 0 | $0 |
| Abraham Bassan | Administrateur | 26 juin 2026 A | — | 0 | 0 | $0 |
| Jake Simson | Administrateur | 26 juin 2026 A | — | 0 | 0 | $0 |
| Bernard Coulie | Administrateur | 26 juin 2026 A | — | 0 | 0 | $0 |
| Alan Ezekowitz | Administrateur | 26 juin 2026 A | 117 420 | 0 | 0 | $0 |
| Keith Michael Gottesdiener | Administrateur | 26 juin 2026 A | — | 0 | 0 | $0 |
| Jeffrey K Tong | Administrateur | 26 juin 2026 A | — | 0 | 0 | $0 |
| Shalini Sharp | Administrateur | 26 juin 2026 A | — | 0 | 0 | $0 |
| Elizabeth Bhatt | — | 11 août 2026 M | 174 209 | 0 | 7 | $-1 449 169 |
| Daniel D. Long | — | 3 août 2026 M | 96 412 | 0 | 7 | $-825 272 |
Initiés issus des déclarations SEC Form 3/4/5 ; net = uniquement P/S de marché
Activistes et détenteurs de 5%+ 1 participation
Investisseurs ayant déposé un Schedule 13D auprès de la SEC — détention effective supérieure à 5% avec l'intention d'influencer l'émetteur (participations activistes, campagnes pour le conseil d'administration, fusions-acquisitions). Chaque ligne montre le dernier état connu de la position du déposant.
| Déclarant | Déposé | Participation | Statut | Objectif | Dépôt |
|---|---|---|---|---|---|
| RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. ×2 dépôts | 14 août 2026 | 11,80% | Amendement | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Détention d'ETF Détenu par 42 ETFs
Le poids reflète uniquement les participations directes en actions (N-PORT) ; les fonds à effet de levier ou basés sur des dérivés peuvent détenir une exposition supplémentaire aux swaps non indiquée.
| Fonds | Poids | Unités | Au | Source |
|---|---|---|---|---|
| PILL · Direxion Shares ETF Trust | 0,69% | 3 760 NS | 30 avril 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0,69% | 10 849 NS | 30 avril 2026 | N-PORT |
| MMSC · First Trust Exchange-Traded Fund VI… | 0,44% | 7 698 NS | 31 mai 2026 | N-PORT |
| IHE · iShares Trust | 0,20% | 84 469 SH | 21 août 2026 | Quotidien |
| SYZ · Lazard Active ETF Trust | 0,17% | 3 405 NS | 30 juin 2026 | N-PORT |
| FSCC · Federated Hermes ETF Trust | 0,14% | 12 566 NS | 31 mai 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,12% | 2 641 SH | 21 août 2026 | Quotidien |
| VFMO · VANGUARD WELLINGTON FUND | 0,08% | 48 858 SH | 19 août 2026 | Quotidien |
| IBB · iShares Trust | 0,08% | 205 741 SH | 21 août 2026 | Quotidien |
| BIB · ProShares Trust | 0,07% | 1 657 NS | 31 mai 2026 | N-PORT |
| AVSC · AMERICAN CENTURY ETF TRUST | 0,06% | 51 545 NS | 31 mai 2026 | N-PORT |
| JPSE · J.P. Morgan Exchange-Traded Fund Tr… | 0,04% | 10 731 NS | 30 avril 2026 | N-PORT |
| IWO · iShares Trust | 0,04% | 138 834 SH | 21 août 2026 | Quotidien |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0,03% | 15 806 SH | 19 août 2026 | Quotidien |
| IWM · iShares Trust | 0,03% | 569 598 SH | 21 août 2026 | Quotidien |
| ISCG · iShares Trust | 0,03% | 6 294 SH | 21 août 2026 | Quotidien |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0,02% | 127 487 SH | 19 août 2026 | Quotidien |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0,02% | 6 423 SH | 19 août 2026 | Quotidien |
| IWN · iShares Trust | 0,02% | 69 141 SH | 21 août 2026 | Quotidien |
| OMFS · Invesco Exchange-Traded Self-Indexe… | 0,02% | 1 228 SH | 21 août 2026 | Quotidien |
| ITWO · ProShares Trust | 0,02% | 1 006 NS | 31 mai 2026 | N-PORT |
| RB · ProShares Trust | 0,02% | 6 NS | 31 mai 2026 | N-PORT |
| RSSL · Global X Funds | 0,02% | 9 265 NS | 30 avril 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,01% | 108 128 NS | 31 mai 2026 | N-PORT |
| ISCB · iShares Trust | 0,01% | 906 SH | 21 août 2026 | Quotidien |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0,01% | 8 841 SH | 21 août 2026 | Quotidien |
| VXF · VANGUARD INDEX FUNDS | 0,01% | 263 629 SH | 19 août 2026 | Quotidien |
| UWM · ProShares Trust | 0,01% | 787 NS | 31 mai 2026 | N-PORT |
| URTY · ProShares Trust | 0,01% | 797 NS | 31 mai 2026 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0,00% | 17 360 NS | 31 mai 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0,00% | 5 127 NS | 30 avril 2026 | N-PORT |
| HDG · ProShares Trust | 0,00% | 20 NS | 31 mai 2026 | N-PORT |
| DFAS · Dimensional ETF Trust | 0,00% | 16 325 NS | 30 avril 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,00% | 675 NS | 31 mai 2026 | N-PORT |
| IWV · iShares Trust | 0,00% | 6 897 SH | 21 août 2026 | Quotidien |
| ITOT · iShares Trust | 0,00% | 29 867 SH | 21 août 2026 | Quotidien |
| SCHB · SCHWAB STRATEGIC TRUST | 0,00% | 11 580 NS | 31 mai 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0,00% | 418 NS | 30 avril 2026 | N-PORT |
| AVUS · AMERICAN CENTURY ETF TRUST | 0,00% | 672 NS | 31 mai 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0,00% | 927 665 SH | 19 août 2026 | Quotidien |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0,00% | 1 866 SH | 19 août 2026 | Quotidien |
| VHT · VANGUARD WORLD FUND | 0,00% | 29 744 SH | 19 août 2026 | Quotidien |