| RA CAPITAL MANAGEMENT, L.P. |
$67304808 |
12723026 |
10.40% |
शेयर
|
| BML Capital Management, LLC |
$63347750 |
11975000 |
9.79% |
शेयर
|
| BlackRock, Inc. |
$53095772 |
10037008 |
8.21% |
शेयर
|
| Deep Track Capital, LP |
$49435050 |
9345000 |
7.64% |
शेयर
|
| Vivo Capital, LLC |
$35414630 |
6694637 |
5.47% |
शेयर
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$30776511 |
5817866 |
4.76% |
शेयर
|
| Frazier Life Sciences Management, L.P. |
$26055228 |
4925374 |
4.03% |
शेयर
|
| Rock Springs Capital Management LP |
$22908514 |
4330532 |
3.54% |
शेयर
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$21535590 |
4071000 |
3.33% |
शेयर
|
| Decheng Capital LLC |
$21380783 |
4041736 |
3.30% |
शेयर
|
| VANGUARD GROUP INC |
$19571260 |
6502080 |
3.02% |
शेयर
|
| STATE STREET CORP |
$17220749 |
3255340 |
2.66% |
शेयर
|
| GEODE CAPITAL MANAGEMENT, LLC |
$16879468 |
3190058 |
2.61% |
शेयर
|
| BRAIDWELL LP |
$11333021 |
2142348 |
1.75% |
शेयर
|
| Balyasny Asset Management L.P. |
$10704156 |
2023470 |
1.65% |
शेयर
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$10296890 |
1946482 |
1.59% |
शेयर
|
| Kalehua Capital Management LLC |
$9693211 |
1832365 |
1.50% |
शेयर
|
| CITADEL ADVISORS LLC |
$9321408 |
1762081 |
1.44% |
शेयर
|
| Jones Hill Capital LP |
$9307713 |
1759492 |
1.44% |
शेयर
|
| Palo Alto Investors LP |
$8535045 |
1613430 |
1.32% |
शेयर
|
| Woodline Partners LP |
$8522476 |
1611054 |
1.32% |
शेयर
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7753738 |
1465735 |
1.20% |
शेयर
|
| PANAGORA ASSET MANAGEMENT INC |
$7174044 |
1356152 |
1.11% |
शेयर
|
| Connor, Clark & Lunn Investment Management Ltd. |
$6400297 |
1209886 |
0.99% |
शेयर
|
| MPM BIOIMPACT LLC |
$5514650 |
1042467 |
0.85% |
शेयर
|
| DEUTSCHE BANK AG\ |
$5506652 |
1040955 |
0.85% |
शेयर
|
| NORTHERN TRUST CORP |
$5283456 |
998763 |
0.82% |
शेयर
|
| KOTLER KEVIN |
$5134846 |
1705929 |
0.79% |
शेयर
|
| Aldebaran Capital, LLC |
$4955307 |
936731 |
0.77% |
शेयर
|
| VANGUARD FIDUCIARY TRUST CO |
$4798945 |
907173 |
0.74% |
शेयर
|
| RENAISSANCE TECHNOLOGIES LLC |
$4324739 |
817531 |
0.67% |
शेयर
|
| Three Bridge Wealth Advisors, LLC |
$3781414 |
714823 |
0.58% |
शेयर
|
| GOLDMAN SACHS GROUP INC |
$3222447 |
609158 |
0.50% |
शेयर
|
| MILLENNIUM MANAGEMENT LLC |
$2771405 |
523895 |
0.43% |
शेयर
|
| CITADEL ADVISORS LLC |
$2756090 |
521000 |
0.43% |
कॉल ऑप्शन
|
| DIMENSIONAL FUND ADVISORS LP |
$2714467 |
513840 |
0.42% |
शेयर
|
| JPMORGAN CHASE & CO |
$2354200 |
468964 |
0.36% |
शेयर
|
| Aisling Capital Management LP |
$2298267 |
434455 |
0.36% |
शेयर
|
| ORBIMED ADVISORS LLC |
$2229735 |
421500 |
0.34% |
शेयर
|
| D. E. Shaw & Co., Inc. |
$2192700 |
414499 |
0.34% |
शेयर
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2182384 |
412549 |
0.34% |
शेयर
|
| Tetragon Partners GP Ltd |
$2116000 |
400000 |
0.33% |
शेयर
|
| Russell Investments Group, Ltd. |
$1931139 |
365055 |
0.30% |
शेयर
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1830647 |
346058 |
0.28% |
शेयर
|
| FMR LLC |
$1660267 |
313850 |
0.26% |
शेयर
|
| Bank of New York Mellon Corp |
$1494949 |
282599 |
0.23% |
शेयर
|
| Nuveen, LLC |
$1472758 |
278404 |
0.23% |
शेयर
|
| RAYMOND JAMES FINANCIAL INC |
$1457982 |
275611 |
0.23% |
शेयर
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1415064 |
267498 |
0.22% |
शेयर
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$1363101 |
257675 |
0.21% |
शेयर
|
| UBS Group AG |
$1359536 |
257001 |
0.21% |
शेयर
|
| Invesco Ltd. |
$1285618 |
243028 |
0.20% |
शेयर
|
| HighTower Advisors, LLC |
$1150702 |
217524 |
0.18% |
शेयर
|
| Creative Planning |
$1093163 |
206647 |
0.17% |
शेयर
|
| Logos Global Management LP |
$1058000 |
200000 |
0.16% |
शेयर
|
| Verdad Advisers, LP |
$927189 |
175272 |
0.14% |
शेयर
|
| Informed Momentum Co LLC |
$906320 |
171327 |
0.14% |
शेयर
|
| Assenagon Asset Management S.A. |
$817591 |
154554 |
0.13% |
शेयर
|
| Atom Investors LP |
$787443 |
148855 |
0.12% |
शेयर
|
| TWO SIGMA ADVISERS, LP |
$768754 |
255400 |
0.12% |
शेयर
|
| RHUMBLINE ADVISERS |
$757603 |
143216 |
0.12% |
शेयर
|
| ALPS ADVISORS INC |
$749852 |
141749 |
0.12% |
शेयर
|
| SEI INVESTMENTS CO |
$734136 |
138778 |
0.11% |
शेयर
|
| MORGAN STANLEY |
$709477 |
134117 |
0.11% |
शेयर
|
| TWO SIGMA INVESTMENTS, LP |
$703930 |
133068 |
0.11% |
शेयर
|
| Vanguard Global Advisers, LLC |
$682706 |
129056 |
0.11% |
शेयर
|
| Hudson Bay Capital Management LP |
$634800 |
120000 |
0.10% |
शेयर
|
| CenterBook Partners LP |
$625426 |
118228 |
0.10% |
शेयर
|
| CITIGROUP INC |
$623088 |
117786 |
0.10% |
शेयर
|
| BANK OF AMERICA CORP /DE/ |
$584080 |
110412 |
0.09% |
शेयर
|
| WELLS FARGO & COMPANY/MN |
$574748 |
108648 |
0.09% |
शेयर
|
| CITADEL ADVISORS LLC |
$550160 |
104000 |
0.09% |
पुट ऑप्शन
|
| Verition Fund Management LLC |
$518420 |
98000 |
0.08% |
शेयर
|
| STRS OHIO |
$430606 |
81400 |
0.07% |
शेयर
|
| Voleon Capital Management LP |
$408219 |
77168 |
0.06% |
शेयर
|
| Susquehanna Portfolio Strategies, LLC |
$403468 |
76270 |
0.06% |
शेयर
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$396851 |
75019 |
0.06% |
शेयर
|
| BARCLAYS PLC |
$386223 |
73010 |
0.06% |
शेयर
|
| MetLife Investment Management, LLC |
$368708 |
69699 |
0.06% |
शेयर
|
| AQR CAPITAL MANAGEMENT LLC |
$318771 |
60259 |
0.05% |
शेयर
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$288718 |
54578 |
0.04% |
शेयर
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$280899 |
53100 |
0.04% |
पुट ऑप्शन
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$271906 |
51400 |
0.04% |
कॉल ऑप्शन
|
| MANGROVE PARTNERS IM, LLC |
$266039 |
50291 |
0.04% |
शेयर
|
| DIVERSIFIED TRUST CO |
$240816 |
45523 |
0.04% |
शेयर
|
| ALLIANCEBERNSTEIN L.P. |
$213750 |
57000 |
0.03% |
शेयर
|
| Police & Firemen's Retirement System of New Jersey |
$205390 |
38826 |
0.03% |
शेयर
|
| BNP PARIBAS FINANCIAL MARKETS |
$187922 |
35524 |
0.03% |
शेयर
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$171428 |
32406 |
0.03% |
शेयर
|
| PROFUND ADVISORS LLC |
$161271 |
30486 |
0.02% |
शेयर
|
| State of Wyoming |
$145152 |
27439 |
0.02% |
शेयर
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$144417 |
27300 |
0.02% |
शेयर
|
| INTECH INVESTMENT MANAGEMENT LLC |
$130494 |
24668 |
0.02% |
शेयर
|
| VOYA INVESTMENT MANAGEMENT LLC |
$122220 |
23104 |
0.02% |
शेयर
|
| China Universal Asset Management Co., Ltd. |
$117586 |
22228 |
0.02% |
शेयर
|
| Rafferty Asset Management, LLC |
$116364 |
21997 |
0.02% |
शेयर
|
| PRUDENTIAL FINANCIAL INC |
$107228 |
20270 |
0.02% |
शेयर
|
| ProShare Advisors LLC |
$106302 |
20095 |
0.02% |
शेयर
|
| Verition Fund Management LLC |
$105800 |
20000 |
0.02% |
कॉल ऑप्शन
|
| Walleye Capital LLC |
$103557 |
19576 |
0.02% |
शेयर
|
| NEUBERGER BERMAN GROUP LLC |
$102451 |
19367 |
0.02% |
शेयर
|
| Vontobel Holding Ltd. |
$95220 |
18000 |
0.01% |
शेयर
|
| CRA Financial Services, LLC |
$94067 |
17782 |
0.01% |
शेयर
|
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management |
$85021 |
16072 |
0.01% |
शेयर
|
| Vanguard Personalized Indexing Management, LLC |
$83005 |
15691 |
0.01% |
शेयर
|
| Dynamic Technology Lab Private Ltd |
$72000 |
13521 |
0.01% |
शेयर
|
| VICTORY CAPITAL MANAGEMENT INC |
$67278 |
12718 |
0.01% |
शेयर
|
| TWO SIGMA SECURITIES, LLC |
$67030 |
12671 |
0.01% |
शेयर
|
| Legal & General Group Plc |
$60930 |
11518 |
0.01% |
शेयर
|
| XPONANCE LLC |
$59634 |
11273 |
0.01% |
शेयर
|
| Jefferies Financial Group Inc. |
$58190 |
11000 |
0.01% |
शेयर
|
| Quadrature Capital Ltd |
$57635 |
10895 |
0.01% |
शेयर
|
| Ameritas Investment Partners, Inc. |
$56899 |
10756 |
0.01% |
शेयर
|
| MERCER GLOBAL ADVISORS INC /ADV |
$56540 |
10688 |
0.01% |
शेयर
|
| M&T Bank Corp |
$55630 |
10516 |
0.01% |
शेयर
|
| JANE STREET GROUP, LLC |
$54487 |
10300 |
0.01% |
कॉल ऑप्शन
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$50260 |
9501 |
0.01% |
शेयर
|
| Tower Research Capital LLC (TRC) |
$39728 |
7510 |
0.01% |
शेयर
|
| Mirae Asset Global Investments Co., Ltd. |
$33041 |
6246 |
0.01% |
शेयर
|
| Rockefeller Capital Management L.P. |
$32333 |
6112 |
0.00% |
शेयर
|
| Caitong International Asset Management Co., Ltd |
$30031 |
5677 |
0.00% |
शेयर
|
| SIMPLEX TRADING, LLC |
$29089 |
5499 |
0.00% |
शेयर
|
| ROYAL BANK OF CANADA |
$23000 |
4394 |
0.00% |
शेयर
|
| Quantbot Technologies LP |
$20033 |
3787 |
0.00% |
शेयर
|
| GF FUND MANAGEMENT CO. LTD. |
$13505 |
2553 |
0.00% |
शेयर
|
| PNC Financial Services Group, Inc. |
$10924 |
2065 |
0.00% |
शेयर
|
| ACADIAN ASSET MANAGEMENT LLC |
$8677 |
1641472 |
0.00% |
शेयर
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$6798 |
1285 |
0.00% |
शेयर
|
| Farther Finance Advisors, LLC |
$6216 |
1175 |
0.00% |
शेयर
|
| GAMMA Investing LLC |
$5396 |
1020 |
0.00% |
शेयर
|
| CWM, LLC |
$5093 |
1358 |
0.00% |
शेयर
|
| Arax Advisory Partners |
$4158 |
786 |
0.00% |
शेयर
|
| OSAIC HOLDINGS, INC. |
$3887 |
735 |
0.00% |
शेयर
|
| Sterling Capital Management LLC |
$3629 |
686 |
0.00% |
शेयर
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$2645 |
500 |
0.00% |
शेयर
|
| HUNTINGTON NATIONAL BANK |
$2423 |
458 |
0.00% |
शेयर
|
| Bollard Group LLC |
$2283 |
431631 |
0.00% |
शेयर
|
| MassMutual Private Wealth & Trust, FSB |
$2068 |
391 |
0.00% |
शेयर
|
| Parallel Advisors, LLC |
$1889 |
357 |
0.00% |
शेयर
|
| Smartleaf Asset Management LLC |
$1888 |
376 |
0.00% |
शेयर
|
| Optiver Holding B.V. |
$1777 |
336 |
0.00% |
शेयर
|
| NISA INVESTMENT ADVISORS, LLC |
$1682 |
318 |
0.00% |
शेयर
|
| Cornerstone Financial Management LLC |
$1428 |
270 |
0.00% |
शेयर
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1173 |
221599 |
0.00% |
शेयर
|
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ |
$825 |
156 |
0.00% |
शेयर
|
| Truvestments Capital LLC |
$794 |
150 |
0.00% |
शेयर
|
| SJS Investment Consulting Inc. |
$540 |
102 |
0.00% |
शेयर
|
| NATIONAL BANK OF CANADA /FI/ |
$540 |
102 |
0.00% |
शेयर
|
| Allworth Financial LP |
$461 |
87 |
0.00% |
शेयर
|
| SBI Securities Co., Ltd. |
$354 |
67 |
0.00% |
शेयर
|
| Fortitude Family Office, LLC |
$296 |
56 |
0.00% |
शेयर
|
| Cambridge Investment Research Advisors, Inc. |
$222 |
41873 |
0.00% |
शेयर
|
| SG Americas Securities, LLC |
$184 |
34814 |
0.00% |
शेयर
|
| EverSource Wealth Advisors, LLC |
$101 |
19 |
0.00% |
शेयर
|
| ROTHSCHILD INVESTMENT LLC |
$48 |
9 |
0.00% |
शेयर
|
| Clearstead Advisors, LLC |
$32 |
6 |
0.00% |
शेयर
|
| Essential Partners LLC |
$26 |
5 |
0.00% |
शेयर
|
| Motiv8 Investments LLC |
$3 |
1000 |
0.00% |
शेयर
|
| Capital Advisors, Ltd. LLC |
$2 |
454 |
0.00% |
शेयर
|