David A Eichler

Insider

First SEC filing: March 29, 2007 · Latest: March 29, 2007

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Insider at

0 buys (P) 0 sells (S) Net: $0 + 10 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

No open-market trades on record; showing all filings.

Date	Ticker	Code	Shares	Price	Value	Owned after	Δ own	A/D	vs now
Sept. 19, 2007	OPK	A	20,000	—	—	20,000 Direct	—	Acquired	(price as of 2026-08-18)
May 3, 2007	OPK	A	20,000	—	—	20,000 Direct	—	Acquired	(price as of 2026-08-18)
March 27, 2007	OPK	J	155,682	—	—	155,682 Indirect	—	Acquired	(price as of 2026-08-18)
March 27, 2007	OPK	J	103,788	—	—	103,788 Indirect	—	Acquired	(price as of 2026-08-18)
March 27, 2007	OPK	J	25,947	—	—	25,947 Indirect	—	Acquired	(price as of 2026-08-18)
March 27, 2007	OPK	J	309,737	—	—	309,737 Indirect	—	Acquired	(price as of 2026-08-18)
March 27, 2007	OPK	J	309,737	—	—	309,737 Indirect	—	Acquired	(price as of 2026-08-18)
March 27, 2007	OPK	J	309,737	—	—	309,737 Indirect	—	Acquired	(price as of 2026-08-18)
March 27, 2007	OPK	J	1,135,188	—	—	1,135,188 Indirect	—	Acquired	(price as of 2026-08-18)
March 27, 2007	OPK	J	90,815	—	—	90,815 Indirect	—	Acquired	(price as of 2026-08-18)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Options, RSUs and convertible securities reported on Form 4 Table II.

Date	Ticker	Security	Underlying	Exercise price	Expiration	Shares	A/D
Sept. 19, 2007	OPK	Stock Option	Common Stock (20,000)	$4.15	Sept. 19, 2014	20,000	Acquired
May 3, 2007	OPK	Stock Option (Right to Buy)	Common Stock (20,000)	$4.88	May 3, 2014	20,000	Acquired
March 27, 2007	OPK	Stock Option (Right to Buy)	Common Stock (155,682)	$0.05	Feb. 28, 2016	155,682	Acquired
March 27, 2007	OPK	Stock Option (Right to Buy)	Common Stock (103,788)	$0.04	Feb. 15, 2015	103,788	Acquired
March 27, 2007	OPK	Stock Option (Right to Buy)	Common Stock (25,947)	$0.04	Nov. 8, 2014	25,947	Acquired
March 27, 2007	OPK	Warrant (Right to Buy)	Common Stock (309,737)	$1.05	March 27, 2017	309,737	Acquired
March 27, 2007	OPK	Warrant (Right to Buy)	Common Stock (309,737)	$0.85	March 27, 2017	309,737	Acquired
March 27, 2007	OPK	Warrant(Right to Buy)	Common Stock (309,737)	$0.67	March 27, 2017	309,737	Acquired
March 27, 2007	OPK	Warrant (Right to Buy)	Common Stock (1,135,188)	$0.00	March 27, 2017	1,135,188	Acquired
March 27, 2007	OPK	Series C Convertible Preferred Stock	Common Stock (9,081,500)	$0.00	—	90,815	Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Securities held when first becoming an insider, per SEC Form 3.

Date	Ticker	Security	Shares	Ownership
March 29, 2007	OPK	Series C Convertible Preferred Stock→ Common Stock (9,081,500)	9,081,500	Indirect
March 29, 2007	OPK	Warrant (Right to Buy)→ Common Stock (1,135,188)	1,135,188	Indirect
March 29, 2007	OPK	WArrant (Right to Buy)→ Common Stock (309,737)	309,737	Indirect
March 29, 2007	OPK	Warrant (Right to Buy)→ Common Stock (309,737)	309,737	Indirect
March 29, 2007	OPK	Warrant (Right to Buy)→ Common Stock (309,737)	309,737	Indirect
March 29, 2007	OPK	Stock Option (Right to Buy)→ Common Stock (25,947)	25,947	Indirect
March 29, 2007	OPK	Stock Option (Right to Buy)→ Common Stock (103,788)	103,788	Indirect
March 29, 2007	OPK	Stock Option (Right to Buy)→ Common Stock (155,682)	155,682	Indirect