OPK Opko Health, Inc. - Common Stock

NASDAQ · Health Care · View on SEC EDGAR ↗
$1.39
Price · Aug 19, 2026
Fundamentals as of Jul 27, 2026

OPK Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$1.39
Market Cap
P/E (TTM)
-4.2
EPS (TTM)
$-0.30
Revenue (TTM)
$607M
Div Yield
ROE
-17.6%
Debt/Equity
0.3
52W Range
$1 – $2

OPK Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $607M
10-point trend, -45.7%
2016-12-31 2025-12-31
EPS $-0.30
10-point trend, -200.0%
2016-12-31 2025-12-31
Free Cash Flow $-191M
8-point trend, -1513.6%
2016-12-31 2025-12-31
Margins -37.2%
2025-12-31 2025-12-31

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
OPK
Peer Median
P/E (TTM)
5-point trend, +95.6%
-4.2
43.5

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
OPK
Peer Median
Gross Margin
33.9%
27.6%
Operating Margin
5-point trend, +36.3%
-19.4%
Net Profit Margin
5-point trend, -6.5%
-37.2%
-0.95%
ROA
5-point trend, +17.5%
-10.9%
-0.27%
ROE
5-point trend, +9.0%
-17.6%
-0.87%
ROIC
5-point trend, +60.7%
-6.8%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
OPK
Peer Median
Debt / Equity
5-point trend, +3693.1%
0.3
Current Ratio
5-point trend, +205.0%
4.0
3.4
Quick Ratio
5-point trend, +250.9%
3.1

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
OPK
Peer Median
Revenue YoY
5-point trend, -65.8%
-14.9%
Revenue CAGR 3Y
5-point trend, -65.8%
-15.4%
Revenue CAGR 5Y
5-point trend, -65.8%
-15.8%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
OPK
Peer Median
EPS (Diluted)
5-point trend, -500.0%
$-0.30

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
OPK
Peer Median

OPK Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 10 analysts
  • Strong Buy 2 20.0%
  • Buy 5 50.0%
  • Hold 3 30.0%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

4 analysts · 2026-08-15
Median target $3.00 +115.8%
Mean target $4.38 +214.7%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.01%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.01 $-0.08 0.07%
March 31, 2026 $-0.07 $-0.07 0.00%
Dec. 31, 2025 $-0.04 $-0.07 0.03%
Sept. 30, 2025 $0.03 $-0.05 0.08%
June 30, 2025 $-0.19 $-0.11 -0.08%
March 31, 2025 $-0.10 $-0.07 -0.03%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
OPK -4.2 -14.9% -37.2% -17.6% 33.9%
INNV $500M -16.8 11.8% -3.5% -12.0% 18.0%
OMDA $922M -45.1 53.2% -4.9% -5.8% 65.7%
PNTG $975M 33.5 36.3% 3.1% 8.4%
AMN $606M -6.4 -8.5% -3.5% -15.3% 28.3%
LMRI
CSTL $1.15B -46.9 3.7% -7.0% -5.2%
GMRS
CVS $100.87B 57.1 7.8% 0.44% 2.4%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 18
Annual Income Statement data for OPK
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +566.0% $607M $713M $863M $1.00B $1.77B $1.44B $902M $990M $966M $1.12B $492M $91M
Cost of Revenue 8-point trend, +4178.1% $401M $495M $545M $716M · · · · $61M $47M $42M $9M
Gross Profit 4-point trend, -28.5% $206M $219M $318M $288M · · · · · · · ·
R&D Expense 12-point trend, +48.4% $124M $105M $90M $74M $77M $75M $118M $126M $126M $114M $99M $84M
SG&A Expense 12-point trend, +284.9% $223M $304M $301M $373M $469M $356M $343M $358M $415M $407M $197M $58M
Operating Expenses 10-point trend, +330.7% · · $1.02B $1.23B $1.76B $1.38B $1.18B $1.16B $1.24B $1.21B $590M $237M
Operating Income 12-point trend, +19.5% $-117M $-152M $-157M $-226M $19M $58M $-274M $-171M $-276M $-97M $-98M $-146M
Interest Expense 4-point trend, -100.0% $0 · $14M $12M $19M · · · · · · ·
Interest Income 5-point trend, +52796.4% $15M $8M $4M $2M $28.0K · · · · · · ·
Other Non-op 12-point trend, -867.5% $-30M $207M $-17M $-156M $-15M $13M $-11M $2M $10M $4M $8M $-3M
Pretax Income 12-point trend, -41.1% $-241M $-10M $-184M $-392M $-14M $49M $-305M $-177M $-272M $-97M $-138M $-171M
Income Tax 12-point trend, -65570.8% $-16M $43M $4M $-63M $15M $18M $7M $-39M $19M $-56M $-114M $24.0K
Net Income 12-point trend, -31.5% $-226M $-53M $-189M $-328M $-30M $31M $-315M $-153M $-305M $-48M $-30M $-172M
EPS (Basic) 10-point trend, -233.3% $-0.30 $-0.08 $-0.25 $-0.46 $-0.05 $0.05 $-0.53 $-0.27 $-0.55 $-0.09 · ·
EPS (Diluted) 10-point trend, -200.0% $-0.30 $-0.08 $-0.25 $-0.46 $-0.05 $0.05 $-0.53 $-0.27 $-0.55 $-0.10 · ·
Shares (Basic) 10-point trend, +36.4% 751,132,891 694,019,535 751,765,915 719,060,942 648,077,716 640,655,290 595,454,394 563,143,663 559,160,565 550,846,553 · ·
Shares (Diluted) 10-point trend, +35.2% 751,132,891 694,019,535 751,765,915 719,060,942 648,077,716 640,655,290 595,454,394 563,143,663 559,160,565 555,605,448 · ·
EBITDA 8-point trend, -210.6% $-26M · $-52M $-118M · $143M $-180M $-74M $-178M $23M · ·
Balance Sheet 30
Annual Balance Sheet data for OPK
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +276.0% $364M $427M $96M $153M $135M $72M $85M $96M $91M $169M $194M $97M
Short-term Investments · · · · · · · · · · $0 ·
Receivables 12-point trend, +352.0% $90M $118M $123M $127M $260M $286M $135M $144M $166M $220M $194M $20M
Inventory 12-point trend, +296.4% $66M $57M $66M $74M $87M $132M $53M $42M $49M $47M $40M $17M
Prepaid Expense 12-point trend, +504.2% $57M $55M $25M $40M $27M $32M $51M $35M $43M $47M $27M $9M
Other Current Assets 12-point trend, +93.9% $8M $11M $8M $6M $6M $5M $16M $4M $9M $8M $903.0K $4M
Current Assets 12-point trend, +307.3% $582M $662M $309M $395M $823M $523M $324M $318M $349M $484M $454M $143M
PP&E (Net) 11-point trend, +350.5% $74M $70M $75M $83M · $141M $127M $145M $147M $123M $132M $16M
Accum. Depreciation 9-point trend, +1094.0% $126M $139M $157M $142M · · · $112M $86M $57M $27M $11M
Goodwill 12-point trend, +115.9% $484M $529M $598M $596M $521M $681M $672M $700M $717M $705M $743M $224M
Intangibles 12-point trend, +724.1% $516M $617M $740M $824M $322M $475M $529M $614M $684M $764M $638M $63M
Other Non-current Assets 12-point trend, +233.6% $19M $19M $9M $9M $10M $10M $7M $7M $6M $6M $5M $6M
Total Assets 12-point trend, +52.4% $1.93B $2.20B $2.01B $2.17B $2.40B $2.47B $2.31B $2.45B $2.59B $2.77B $2.80B $1.27B
Accounts Payable 12-point trend, +370.1% $41M $47M $70M $67M $82M $101M $63M $47M $74M $53M $73M $9M
Accrued Liabilities 12-point trend, +38.6% $84M $118M $90M $98M $193M $241M $165M $204M $226M $198M $168M $61M
Current Liabilities 12-point trend, +76.5% $147M $193M $200M $213M $330M $375M $249M $288M $312M $263M $252M $83M
Capital Leases 12-point trend, +36815000.00 $37M $49M $54M $28M $33M $30M $28M $6M $8M $7M $9M $0
Deferred Tax 12-point trend, -24.5% $126M $141M $127M $126M $148M $137M $119M $115M $149M $165M $226M $167M
Other Non-current Liabilities 12-point trend, -54.6% $23M $33M $27M $27M $15M $37M $88M $199M $256M $202M $292M $50M
Total Liabilities 12-point trend, +53.7% $664M $835M $622M $606M $715M $802M $695M $660M $746M $675M $819M $432M
Long-term Debt 12-point trend, +2064.8% $344M $437M $50.6K $256M $205M $251M $270M $11M $13M $13M $14M $16M
Total Debt 6-point trend, +2626.6% $346M · $10M · · · $4M $11M $13M $13M · ·
Common Stock 12-point trend, +82.3% $8M $7M $8M $8M $7M $7M $7M $6M $6M $6M $5M $4M
Paid-in Capital 12-point trend, +133.8% $3.57B $3.48B $3.43B $3.42B $3.22B $3.15B $3.14B $3.00B $2.89B $2.85B $2.71B $1.53B
Retained Earnings 12-point trend, -239.4% $-2.29B $-2.07B $-2.01B $-1.82B $-1.51B $-1.48B $-1.51B $-1.20B $-1.05B $-730M $-705M $-675M
Treasury Stock 12-point trend, -21.6% $3M $2M $2M $2M $2M $2M $2M $2M $2M $2M $4M $4M
AOCI 12-point trend, -69.6% $-21M $-56M $-38M $-43M $-30M $-4M $-22M $-20M $-528.0K $-27M $-23M $-12M
Stockholders' Equity 12-point trend, +51.7% $1.27B $1.37B $1.39B $1.56B $1.69B $1.67B $1.61B $1.79B $1.84B $2.05B $1.96B $836M
Liabilities + Equity 12-point trend, +52.4% $1.93B $2.20B $2.01B $2.17B $2.40B $2.47B $2.31B $2.45B $2.59B $2.77B $2.80B $1.27B
Shares Outstanding 6-point trend, +4.6% · 701,350,447 781,936,885 781,306,164 690,082,283 670,585,576 670,378,701 · · · · ·
Cash Flow 16
Annual Cash Flow data for OPK
Metric Trend 202520242023202220212020201920182017201620152014
D&A 12-point trend, +513.8% $92M $98M $105M $109M $79M $85M $94M $97M $102M $97M $42M $15M
Stock-based Comp 12-point trend, -27.5% $11M $11M $11M $19M $14M $9M $13M $22M $28M $43M $26M $15M
Deferred Tax 12-point trend, -1373.4% $-15M $15M $146.0K $-74M $10M $16M $4M $-35M $16M $-61M $-124M $-1M
Amort. of Intangibles 12-point trend, +614.6% $78M $83M $86M $88M $50M $56M $65M $68M $71M $64M $28M $11M
Other Non-cash 8-point trend, -94.6% $-40M · $44M $180M · $-101M $31M $-40M $70M $-21M · ·
Operating Cash Flow 12-point trend, -97.5% $-179M $-183M $-28M $-95M $38M $39M $-173M $-109M $-92M $32M $164M $-90M
CapEx 12-point trend, +159.4% $12M $25M $16M $25M $32M $34M $13M $28M $47M $19M $11M $5M
Investing Cash Flow 12-point trend, +4158.1% $230M $352M $-18M $91M $36M $-18M $-13M $-26M $-47M $-21M $-99M $-6M
Stock Issued 6-point trend, +0.00 · · · · $0 $0 $76M $92M $0 $0 · ·
Stock Repurchased 4-point trend, +47040000.00 $47M $90M $0 $0 · · · · · · · ·
Net Stock Activity 4-point trend, -150.9% $-47M · · · · $0 $76M $92M · · · ·
Financing Cash Flow 12-point trend, -1725.4% $-118M $184M $-11M $23M $-10M $-35M $175M $141M $61M $-35M $33M $7M
Net Change in Cash 12-point trend, +29.3% $-63M $350M $-57M $18M $62M $-13M $-11M $5M $-77M $-25M $97M $-89M
Taxes Paid 12-point trend, +2464.3% $24M $10M $4M $8M $6M $-903.0K $3M $-1M $5M $-27M $5M $954.0K
Free Cash Flow 8-point trend, -1513.6% $-191M · $-44M $-120M · $6M $-185M $-137M $-139M $13M · ·
Levered FCF 2-point trend, -227.3% $-191M · $-58M · · · · · · · · ·
Profitability 8
Annual Profitability data for OPK
Metric Trend 202520242023202220212020201920182017201620152014
Gross Margin 33.9% · · · · · · · · · · ·
Operating Margin 8-point trend, -222.5% -19.4% · -18.2% -22.5% · 4.0% -30.4% -17.3% -26.2% -6.0% · ·
Net Margin 8-point trend, -1714.1% -37.2% · -21.9% -32.7% · 2.1% -34.9% -15.4% -28.9% -2.1% · ·
Pretax Margin 8-point trend, -560.6% -39.8% · -21.3% -39.0% · 3.4% -33.8% -17.9% -25.8% -6.0% · ·
EBITDA Margin 8-point trend, -322.5% -4.2% · -6.0% -11.7% · 10.0% -20.0% -7.5% -16.7% 1.9% · ·
ROA 8-point trend, -1113.3% -10.9% · -9.0% -14.4% · 1.3% -13.2% -6.1% -11.5% -0.90% · ·
ROE 8-point trend, -1319.4% -17.6% · -13.3% -20.6% · 1.9% -19.3% -8.6% -15.7% -1.2% · ·
ROIC 8-point trend, -719.3% -6.8% · -11.5% -12.1% · 2.2% -17.3% -7.4% -15.8% -0.83% · ·
Liquidity & Solvency 5
Annual Liquidity & Solvency data for OPK
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 8-point trend, +116.0% 4.0 · 1.5 1.8 · 1.4 1.3 1.1 1.1 1.8 · ·
Quick Ratio 8-point trend, +109.8% 3.1 · 1.1 1.3 · 1.0 0.9 0.8 0.9 1.5 · ·
Debt / Equity 6-point trend, +4377.0% 0.3 · 0.0 · · · 0.0 0.0 0.0 0.0 · ·
LT Debt / Equity 6-point trend, +500.0% 0.0 · 0.0 · · · 0.0 0.0 0.0 0.0 · ·
Interest Coverage · · -11.6 · · · · · · · · ·
Efficiency 3
Annual Efficiency data for OPK
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 8-point trend, -33.1% 0.3 · 0.4 0.4 · 0.6 0.4 0.4 0.4 0.4 · ·
Inventory Turnover 3-point trend, -49.6% 6.5 · · · · · · · 1.3 13.0 · ·
Receivables Turnover 8-point trend, -1.2% 5.8 · 6.9 5.2 · 6.8 6.5 6.4 5.5 5.9 · ·
Per Share 5
Annual Per Share data for OPK
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 2-point trend, -11.1% · · $1.78 $2.00 · · · · · · · ·
Revenue / Share 3-point trend, -54.1% $0.81 · · $1.40 · · · $1.76 · · · ·
Cash Flow / Share 3-point trend, -22.7% $-0.24 · · $-0.13 · · · $-0.19 · · · ·
Cash / Share 2-point trend, -37.5% · · $0.12 $0.20 · · · · · · · ·
EPS (TTM) 12-point trend, +28.6% $-0.30 $-0.08 $-0.25 $-0.46 $-0.05 $0.05 $-0.53 $-0.27 $-0.55 $-0.10 $-0.17 $-0.42
Growth Rates 3
Annual Growth Rates data for OPK
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, -163.0% -14.9% -17.4% -14.0% -43.4% 23.6% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +0.8% -15.4% -26.2% -15.6% · · · · · · · · ·
Revenue CAGR 5Y -15.8% · · · · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for OPK
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +566.0% $607M $713M $863M $1.00B $1.77B $1.44B $902M $990M $966M $1.12B $492M $91M
Net Income TTM 12-point trend, -31.5% $-226M $-53M $-189M $-328M $-30M $31M $-315M $-153M $-305M $-48M $-30M $-172M
Market Cap 2-point trend, +20.9% · · $1.18B $977M · · · · · · · ·
Enterprise Value · · $1.09B · · · · · · · · ·
P/E 12-point trend, +82.3% -4.2 -18.4 -6.0 -2.7 -96.2 79.0 -2.8 -11.1 -8.9 -93.0 -59.1 -23.8
P/S 2-point trend, +40.6% · · 1.4 1.0 · · · · · · · ·
P/B 2-point trend, +35.9% · · 0.8 0.6 · · · · · · · ·
P / Tangible Book 3-point trend, -31.6% · 4.7 23.3 6.9 · · · · · · · ·
P / Cash Flow 2-point trend, -308.1% · · -41.9 -10.3 · · · · · · · ·
P / FCF 2-point trend, -225.6% · · -26.5 -8.2 · · · · · · · ·
EV / EBITDA · · -21.2 · · · · · · · · ·
EV / FCF · · -24.6 · · · · · · · · ·
EV / Revenue · · 1.3 · · · · · · · · ·
Earnings Yield 12-point trend, -466.9% -23.8% -5.4% -16.6% -36.8% -1.0% 1.3% -36.0% -9.0% -11.2% -1.1% -1.7% -4.2%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $607M$713M$863M$1.00B$1.77B
Gross Margin % 33.9%
Operating Margin % -19.4%-18.2%-22.5%
Net Income $-226M$-53M$-189M$-328M$-30M
Diluted EPS $-0.30$-0.08$-0.25$-0.46$-0.05
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.30.0
Current Ratio 4.01.51.8
Quick Ratio 3.11.11.3
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-191M$-44M$-120M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 249 filers · $248.0M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
31 (-15 vs prior Q) 30 (+6 vs prior Q) 70 (+20 vs prior Q) 50 (-14 vs prior Q) +1.7M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Rubric Capital Management LP $71,686,865 47,791,243 28.91% Shares
VANGUARD GROUP INC $36,859,001 29,253,175 14.86% Shares
VANGUARD CAPITAL MANAGEMENT LLC $22,453,395 14,968,930 9.05% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $22,402,386 14,934,924 9.03% Shares
STATE STREET CORP $15,463,605 10,309,070 6.24% Shares
GEODE CAPITAL MANAGEMENT, LLC $15,045,909 10,028,199 6.07% Shares
Whitefort Capital Management, LP $6,767,118 4,511,412 2.73% Shares
HIGHBRIDGE CAPITAL MANAGEMENT LLC $5,426,827 3,593,925 2.19% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $5,395,470 3,596,980 2.18% Shares
VANGUARD FIDUCIARY TRUST CO $4,059,353 2,706,235 1.64% Shares
AWM Investment Company, Inc. $3,165,000 2,110,000 1.28% Shares
CITADEL ADVISORS LLC $2,131,383 1,420,922 0.86% Shares
WASHINGTON GROWTH STRATEGIES LLC $2,034,186 1,356,124 0.82% Shares
Y.D. More Investments Ltd $1,876,217 1,257,568 0.76% Shares
BlackRock, Inc. $1,754,084 1,169,389 0.71% Shares
OP Asset Management Ltd $1,739,471 1,159,647 0.70% Shares
UBS Group AG $1,524,612 1,016,408 0.61% Shares
Clearstead Advisors, LLC $1,324,932 883,288 0.53% Shares
Swiss National Bank $1,142,183 761,455 0.46% Shares
DIMENSIONAL FUND ADVISORS LP $1,034,000 689,333 0.42% Shares
PFG Investments, LLC $915,737 610,491 0.37% Shares
Bank of New York Mellon Corp $851,025 567,350 0.34% Shares
Kovack Advisors, Inc. $804,303 536,202 0.32% Shares
RHUMBLINE ADVISERS $748,287 498,861 0.30% Shares
VAN ECK ASSOCIATES CORP $657,968 438,645 0.27% Shares
COMMONWEALTH EQUITY SERVICES, LLC $647,840 431,894 0.26% Shares
Connor, Clark & Lunn Investment Management Ltd. $615,390 410,260 0.25% Shares
DEUTSCHE BANK AG\ $597,905 398,603 0.24% Shares
ALGERT GLOBAL LLC $595,545 397,030 0.24% Shares
GOLDMAN SACHS GROUP INC $531,120 354,080 0.21% Shares
WELLS FARGO & COMPANY/MN $521,306 347,537 0.21% Shares
ALLIANCEBERNSTEIN L.P. $504,655 442,680 0.20% Shares
BANK OF AMERICA CORP /DE/ $472,621 315,081 0.19% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $472,002 414,037 0.19% Shares
VOYA INVESTMENT MANAGEMENT LLC $446,621 297,747 0.18% Shares
VANGUARD ASSET MANAGEMENT, Ltd $441,020 294,013 0.18% Shares
XTX Topco Ltd $429,260 286,173 0.17% Shares
Assenagon Asset Management S.A. $425,502 285,339 0.17% Shares
TUDOR INVESTMENT CORP ET AL $367,232 244,821 0.15% Shares
JANE STREET GROUP, LLC $344,181 229,454 0.14% Shares
MetLife Investment Management, LLC $340,199 226,799 0.14% Shares
Russell Investments Group, Ltd. $321,036 214,024 0.13% Shares
HSBC HOLDINGS PLC $298,949 199,966 0.12% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $278,346 185,564 0.11% Shares
Vanguard Global Advisers, LLC $272,649 181,766 0.11% Shares
CITIGROUP INC $264,851 176,567 0.11% Shares
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM $264,390 176,260 0.11% Shares
TWO SIGMA INVESTMENTS, LP $263,702 175,801 0.11% Shares
GAMCO INVESTORS, INC. ET AL $262,500 175,000 0.11% Shares
GABELLI FUNDS LLC $255,000 170,000 0.10% Shares
FIFTH THIRD BANCORP $255,000 170,000 0.10% Shares
IEQ CAPITAL, LLC $254,138 169,425 0.10% Shares
JPMORGAN CHASE & CO $252,270 167,066 0.10% Shares
Invesco Ltd. $243,471 162,314 0.10% Shares
TWO SIGMA ADVISERS, LP $240,913 191,201 0.10% Shares
JANUS HENDERSON GROUP PLC $236,230 206,314 0.10% Shares
360 Financial, Inc. $225,450 150,300 0.09% Shares
Point72 Asset Management, L.P. $217,851 145,234 0.09% Shares
Teton Advisors, LLC $210,000 140,000 0.08% Shares
MORGAN STANLEY $204,320 136,213 0.08% Shares
Police & Firemen's Retirement System of New Jersey $198,694 132,463 0.08% Shares
Teton Advisors, Inc. $187,440 142,000 0.08% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $178,698 119,132 0.07% Shares
Glenmede Investment Management, LP $175,790 113,413 0.07% Shares
HIGHLINE WEALTH PARTNERS LLC $175,020 116,680 0.07% Shares
State of Wyoming $174,734 116,489 0.07% Shares
NEW YORK STATE COMMON RETIREMENT FUND $171,452 114,301 0.07% Shares
GLENMEDE TRUST CO NA $169,125 112,750 0.07% Shares
Vanguard Investments Australia, Ltd. $166,437 110,958 0.07% Shares
Headlands Technologies LLC $161,984 107,989 0.07% Shares
ARIZONA STATE RETIREMENT SYSTEM $157,088 104,725 0.06% Shares
CITADEL ADVISORS LLC $156,150 104,100 0.06% Call option
U.S. Capital Wealth Advisors, LLC $151,918 133,261 0.06% Shares
COMERICA BANK $151,200 120,000 0.06% Shares
ZAZOVE ASSOCIATES LLC $150,000 100,000 0.06% Shares
BARCLAYS PLC $140,611 93,740 0.06% Shares
Arax Advisory Partners $140,425 93,616 0.06% Shares
KLP KAPITALFORVALTNING AS $136,050 90,700 0.05% Shares
RPg Family Wealth Advisory, LLC $132,928 88,619 0.05% Shares
INTECH INVESTMENT MANAGEMENT LLC $128,825 85,883 0.05% Shares
MERCER GLOBAL ADVISORS INC /ADV $115,212 76,808 0.05% Shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC $113,392 83,994 0.05% Shares
Cubist Systematic Strategies, LLC $111,798 72,127 0.05% Shares
MILLENNIUM MANAGEMENT LLC $108,452 72,301 0.04% Shares
PRUDENTIAL FINANCIAL INC $103,464 68,976 0.04% Shares
OSAIC HOLDINGS, INC. $103,449 68,967 0.04% Shares
Cascade Financial Partners, LLC $99,735 66,490 0.04% Shares
Pictet Asset Management Holding SA $98,243 65,495 0.04% Shares
CAPTRUST FINANCIAL ADVISORS $95,556 63,704 0.04% Shares
NORTHERN TRUST CORP $94,913 63,275 0.04% Shares
Cetera Investment Advisers $91,421 60,947 0.04% Shares
CITADEL ADVISORS LLC $91,050 60,700 0.04% Put option
SUSQUEHANNA INTERNATIONAL GROUP, LLP $89,250 59,500 0.04% Call option
KESTRA PRIVATE WEALTH SERVICES, LLC $87,675 58,450 0.04% Shares
BNP PARIBAS FINANCIAL MARKETS $86,292 57,528 0.03% Shares
Private Advisor Group, LLC $82,952 55,301 0.03% Shares
Zurcher Kantonalbank (Zurich Cantonalbank) $82,710 55,140 0.03% Shares
CWM, LLC $79,611 69,834 0.03% Shares
ProShare Advisors LLC $79,149 52,766 0.03% Shares
FIRST MANHATTAN CO. LLC. $78,225 52,150 0.03% Shares

Company insiders 36 insiders · 11 officers · 23 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Phillip Frost, M.D. CEO & Chairman May 27, 2025 A 3,568,951 0 0 $0
Adam Logal Sr. Vice President, CFO July 24, 2026 F 563,396 0 0 $0
Juan F Rodriguez Sr. Vice President, CFO July 16, 2012 A 0 0 $0
Elias A. Zerhouni Vice Chairman and President May 27, 2025 A 589,600 0 0 $0
Dale R Pfost President March 29, 2007 J 1,687,261 0 0 $0
Steven D Rubin Executive VP-Administration July 24, 2026 F 6,571,966 0 0 $0
Gary J. Nabel Chief Innovation Officer May 27, 2025 A 700,579 0 0 $0
HSIAO JANE PH D Vice Chairman & CTO May 27, 2025 A 28,499,880 0 0 $0
Jon R Cohen SVP OPKO; Exec Chairman BRLI May 10, 2021 P 125,000 0 0 $0
Naveed K Shams Chief Medical Officer & Sr. VP of Research & Development July 7, 2008 P 6,200 0 0 $0
Samuel J Reich Executive VP March 29, 2007 J 490,021 0 0 $0
Prem A Lachman Director June 18, 2026 A 0 0 $0
Alice Lin-Tsing Yu Director June 18, 2026 A 100,000 0 0 $0
Subbarao V Uppaluri Director June 18, 2026 A 162,000 0 0 $0
John A Paganelli Director June 18, 2026 A 394,340 1 0 $11,400
Richard C Pfenniger JR Director June 18, 2026 A 325,000 0 0 $0
Roger Medel MD Director June 18, 2026 A 0 0 $0
Richard M Krasno Director April 23, 2025 A 103,333 0 0 $0
Alexis Borisy Director June 22, 2023 A 312,612 0 0 $0
Anthony J Japour Director March 12, 2020 P 1,000 0 0 $0
Robert A Baron Director Jan. 19, 2017 M 320,773 0 0 $0
Dmitry Kolosov Director May 5, 2016 A 0 0 $0
Pascal J Goldschmidt Director June 9, 2011 A 0 0 $0
Michael Reich Director Jan. 6, 2009 M 202,858 0 0 $0
David A Eichler Director Sept. 19, 2007 A 0 0 $0
Melvin L Rubin MD Director May 3, 2007 A 0 0 $0
SPENCER DAVID LEE Director July 3, 2006 A 809,100 0 0 $0
Robert S Benou Director July 3, 2006 A 35,000 0 0 $0
Opko Health, Inc. 10% owner Aug. 19, 2024 S 2,646,972 0 0 $0
Frost Gamma Investments Trust 10% owner July 13, 2007 P 40,589,183 0 0 $0
Frost Group, LLC 10% owner March 27, 2007 A 0 0 $0
Robert Scott Fishel June 24, 2021 A 60,000 0 0 $0
Richard A Lerner June 24, 2021 A 178,881 0 0 $0
Thomas E Beier Jan. 13, 2017 M 60,000 0 0 $0
John J Huntz JR May 27, 2004 A 35,000 0 0 $0
Gordon F Martin Nov. 10, 2003 A 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 21 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
FROST PHILLIP MD ET AL, Frost Gamma Investments Trust, Frost Nevada Investments Trust ×3 filings July 1, 2026 34.10% Amendment SEC
HSIAO JANE PH D, Hsu Gamma Investments, LP April 3, 2025 4.50% Amendment SEC
OPKO Health, Inc. ×30 filings Nov. 20, 2024 Initial filing SEC
Frost Gamma Investments Trust, Frost Nevada Investments Trust, Phillip Frost, M.D. ×6 filings Nov. 15, 2024 Initial filing SEC
Hsu Gamma Investments, LP, Jane H. Hsiao, Ph.D. ×2 filings Jan. 24, 2024 Initial filing SEC
Gary J. Nabel, M.D., Ph.D., Elizabeth G. Nabel, M.D., Coe M. Magruder, EGN 2021 Trust, GJN 2021 Trust, Nabel Family Investments LLC June 29, 2022 Initial filing Passive investment SEC
Elias A. Zerhouni, M.D., Bruce C. Holbrook, EAZ Zeraz Trust, Zerhouni Irrevocable Trust June 29, 2022 Initial filing Passive investment SEC
Hsu Gamma Investment, L.P., Jane Hsiao, Ph.D. March 20, 2020 Initial filing SEC
The Chiin Hsiung Hsiao Family Trust A, The Chiin Hsiung Hsiao Family Trust B, Hsu Gamma Investment, L.P., Jane Hsiao, Ph.D. Nov. 1, 2019 Initial filing Passive investment SEC
The Frost Group, LLC, Frost Gamma Investments Trust, Frost Nevada Investments Trust, Phillip Frost, M.D. ×15 filings Nov. 1, 2019 Initial filing Passive investment SEC
The Chiin Hsiung Hsiao Family Trust A (2), The Chiin Hsiung Hsiao Family Trust B (2), Hsu Gamma Investment, L.P. (2), Jane Hsiao, Ph.D. (2) Nov. 20, 2018 Initial filing SEC
Jane Hsiao, Ph.D., The Chiin Hsiung Hsiao Family Trust A, The Chiin Hsiung Hsiao Family Trust B, Hsu Gamma Investment, L.P. ×4 filings Dec. 18, 2015 Initial filing Passive investment SEC
The Frost Group, LLC (2), Frost Gamma Investments Trust (2), Phillip Frost, M.D. (2) ×4 filings Feb. 17, 2015 Initial filing Passive investment SEC
OPKO Health, Inc. (2) ×2 filings Jan. 7, 2014 Initial filing SEC
Jane Hsiao, Ph.D. (2), The Chiin Hsiung Hsiao Family Trust A (2), The Chiin Hsiung Hsiao Family Trust B (2), Hsu Gamma Investment, L.P. (2) Sept. 16, 2013 Initial filing M&A / sale SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 35 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
GSSC · Goldman Sachs ETF Trust 0.05% 327,900 NS May 31, 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.02% 139,884 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.02% 19,367 NS May 31, 2026 N-PORT
RSSL · Global X Funds 0.01% 178,325 NS April 30, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.01% 2,044,519 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.01% 15,146 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.01% 200,102 NS April 30, 2026 N-PORT
URTY · ProShares Trust 0.01% 15,321 NS May 31, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.01% 449,453 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 23,187 NS May 31, 2026 N-PORT
TILT · FlexShares Trust 0.00% 58,520 NS April 30, 2026 N-PORT
HDG · ProShares Trust 0.00% 385 NS May 31, 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 330,176 NS May 31, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.00% 341,321 NS April 30, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS July 15, 2026 Daily
VB · VANGUARD INDEX FUNDS July 15, 2026 Daily
VBK · VANGUARD INDEX FUNDS July 15, 2026 Daily
VBR · VANGUARD INDEX FUNDS July 15, 2026 Daily
VTI · VANGUARD INDEX FUNDS July 15, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS July 15, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS July 15, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS July 15, 2026 Daily
ITOT · iShares Trust Aug. 4, 2026 Daily
IWV · iShares Trust Aug. 18, 2026 Daily
IWN · iShares Trust Aug. 17, 2026 Daily
IWM · iShares Trust Aug. 18, 2026 Daily
IBB · iShares Trust Aug. 18, 2026 Daily
IHF · iShares Trust Aug. 18, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust July 13, 2026 Daily
VHT · VANGUARD WORLD FUND July 20, 2026 Daily
ISCB · iShares Trust Aug. 4, 2026 Daily
ISCV · iShares Trust Aug. 4, 2026 Daily
SMMV · iShares Trust Aug. 18, 2026 Daily
WSML · iShares Trust Aug. 4, 2026 Daily
QQQS · Invesco Exchange-Traded Fund Trust … July 20, 2026 Daily