Insider at

04

Insider transactions

05
0 buys (P) 6 sells (S) Net: $-344,391 + 68 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

68 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
April 2, 2026 AGIO S 10b5-1 3,280 $34.71 $113,849 49,306 Direct -6.24% Disposed -8.4% (price as of 2026-10-02)
March 2, 2026 AGIO S 10b5-1 1,187 $28.96 $34,376 34,531 Direct -3.32% Disposed 9.8% (price as of 2026-10-02)
March 2, 2026 AGIO S 10b5-1 1,681 $28.96 $48,682 38,516 Direct -4.18% Disposed 9.8% (price as of 2026-10-02)
March 2, 2026 AGIO S 10b5-1 1,187 $28.96 $34,376 41,329 Direct -2.79% Disposed 9.8% (price as of 2026-10-02)
March 2, 2026 AGIO S 10b5-1 1,163 $28.96 $33,680 44,086 Direct -2.57% Disposed 9.8% (price as of 2026-10-02)
Dec. 30, 2025 AGIO S 10b5-1 2,932 $27.09 $79,428 31,718 Direct -8.46% Disposed 17.4% (price as of 2026-10-02)
June 24, 2025 AGIO S 10b5-1 2,799 $33.54 $93,878 28,650 Direct -8.90% Disposed -5.2% (price as of 2026-10-02)
March 3, 2025 AGIO S 10b5-1 1,137 $35.54 $40,409 18,650 Direct -5.75% Disposed -10.5% (price as of 2026-10-02)
March 3, 2025 AGIO S 10b5-1 1,187 $35.54 $42,186 21,463 Direct -5.24% Disposed -10.5% (price as of 2026-10-02)
March 3, 2025 AGIO S 10b5-1 1,681 $35.54 $59,743 25,449 Direct -6.20% Disposed -10.5% (price as of 2026-10-02)
Nov. 7, 2024 AGIO S 10b5-1 13,411 $52.00 $697,372 24,041 Direct -35.81% Disposed -38.8% (price as of 2026-10-02)
Nov. 7, 2024 AGIO S 10b5-1 8,341 $52.56 $438,403 15,700 Direct -34.69% Disposed -39.5% (price as of 2026-10-02)
March 5, 2024 AGIO S 10b5-1 1,293 $32.57 $42,113 34,518 Direct -3.61% Disposed -2.4% (price as of 2026-10-02)
March 5, 2024 AGIO S 10b5-1 1,349 $32.57 $43,937 37,169 Direct -3.50% Disposed -2.4% (price as of 2026-10-02)
Feb. 14, 2024 AGIO S 10b5-1 545 $25.14 $13,701 31,666 Direct -1.69% Disposed 26.5% (price as of 2026-10-02)
Jan. 24, 2024 AGIO S 10b5-1 1,708 $21.64 $36,961 30,378 Direct -5.32% Disposed 47.0% (price as of 2026-10-02)
Jan. 9, 2024 AGIO S 10b5-1 1,163 $22.99 $26,737 26,336 Direct -4.23% Disposed 38.3% (price as of 2026-10-02)
Aug. 17, 2023 AGIO S 6,395 $26.28 $168,061 23,890 Direct -21.12% Disposed 21.0% (price as of 2026-10-02)
June 30, 2023 AGIO S 1,707 $28.36 $48,411 30,285 Direct -5.34% Disposed 12.1% (price as of 2026-10-02)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
June 18, 2026 AGIO Restricted stock units Common stock (3,000) · · 3,000 Acquired
June 18, 2026 AGIO Performance share units Common stock (3,000) · · 3,000 Disposed
April 2, 2026 AGIO Performance share units Common stock (8,500) · · 8,500 Disposed
March 2, 2026 AGIO Restricted stock units Common stock (4,000) · · 4,000 Disposed
March 2, 2026 AGIO Restricted stock units Common stock (5,666) · · 5,666 Disposed
March 2, 2026 AGIO Restricted stock units Common stock (4,000) · · 4,000 Disposed
March 2, 2026 AGIO Restricted stock units Common stock (3,920) · · 3,920 Disposed
March 1, 2026 AGIO Restricted stock units Common stock (14,000) · · 14,000 Acquired
March 1, 2026 AGIO Stock options (right to buy) Common stock (52,000) $30.23 March 1, 2036 52,000 Acquired
Dec. 30, 2025 AGIO Performance share units Common stock (6,000) · · 6,000 Disposed
June 24, 2025 AGIO Performance share units Common stock (6,000) · · 6,000 Disposed
March 1, 2025 AGIO Restricted stock units Common stock (12,000) · · 12,000 Acquired
March 1, 2025 AGIO Restricted stock units Common stock (11,759) · · 11,759 Acquired
March 1, 2025 AGIO Stock options (right to buy) Common stock (43,500) $35.54 March 1, 2035 43,500 Acquired
March 1, 2025 AGIO Restricted stock units Common stock (3,833) · · 3,833 Disposed
March 1, 2025 AGIO Restricted stock units Common stock (4,000) · · 4,000 Disposed
March 1, 2025 AGIO Restricted stock units Common stock (5,667) · · 5,667 Disposed
March 1, 2024 AGIO Restricted stock units Common stock (17,000) · · 17,000 Acquired
March 1, 2024 AGIO Stock options (right to buy) Common stock (60,000) $32.27 March 1, 2034 60,000 Acquired
March 1, 2024 AGIO Restricted stock units Common stock (3,834) · · 3,834 Disposed
March 1, 2024 AGIO Restricted stock units Common stock (4,000) · · 4,000 Disposed
Feb. 12, 2024 AGIO Restricted stock units Common stock (1,833) · · 1,833 Disposed
Jan. 20, 2024 AGIO Performance share units Common stock (5,750) · · 5,750 Disposed
Jan. 5, 2024 AGIO Performance share units Common stock (3,250) · · 3,250 Disposed
June 28, 2023 AGIO Performance share units Common stock (5,750) · · 5,750 Disposed
March 1, 2023 AGIO Restricted stock units Common stock (12,000) · · 12,000 Acquired
March 1, 2023 AGIO Stock options (right to buy) Common stock (44,000) $25.01 March 1, 2033 44,000 Acquired
March 1, 2023 AGIO Restricted stock units Common stock (3,833) · · 3,833 Disposed
Feb. 14, 2023 AGIO Restricted stock units Common stock (1,738) · · 1,738 Disposed
Feb. 10, 2023 AGIO Restricted stock units Common stock (1,834) · · 1,834 Disposed
Dec. 23, 2022 AGIO Restricted stock units Common stock (8,750) · · 8,750 Disposed
March 1, 2022 AGIO Restricted stock units Common stock (11,500) · · 11,500 Acquired
March 1, 2022 AGIO Stock options (right to buy) Common stock (41,000) $32.20 March 1, 2032 41,000 Acquired
Feb. 22, 2022 AGIO Restricted stock units Common stock (724) · · 724 Disposed
Feb. 14, 2022 AGIO Restricted stock units Common stock (1,738) · · 1,738 Disposed
Feb. 14, 2022 AGIO Restricted stock units Common stock (5,250) · · 5,250 Disposed
Feb. 10, 2022 AGIO Restricted stock units Common stock (1,833) · · 1,833 Disposed

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 12 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Jan. 10, 2022 AGIO Common stock 8,261 Direct
Jan. 10, 2022 AGIO Restricted stock units→ Common stock (724) 724 Direct
Jan. 10, 2022 AGIO Restricted stock units→ Common stock (5,250) 5,250 Direct
Jan. 10, 2022 AGIO Restricted stock units→ Common stock (3,476) 3,476 Direct
Jan. 10, 2022 AGIO Restricted stock units→ Common stock (8,750) 8,750 Direct
Jan. 10, 2022 AGIO Restricted stock units→ Common stock (5,500) 5,500 Direct
Jan. 10, 2022 AGIO Stock options (right to buy)→ Common stock (5,420) 5,420 Direct
Jan. 10, 2022 AGIO Stock options (right to buy)→ Common stock (5,749) 5,749 Direct
Jan. 10, 2022 AGIO Stock options (right to buy)→ Common stock (8,295) 8,295 Direct
Jan. 10, 2022 AGIO Stock options (right to buy)→ Common stock (8,690) 8,690 Direct
Jan. 10, 2022 AGIO Stock options (right to buy)→ Common stock (2,607) 2,607 Direct
Jan. 10, 2022 AGIO Stock options (right to buy)→ Common stock (22,000) 22,000 Direct

Compensation (DEF 14A)

08

Matched by name from proxy statements (DEF 14A) — verify against the filing.

Fiscal yearSalaryBonusStock awards Option awardsNon-equity incentivePension changeOtherTotal
2025 $527,275 · · · $237,274 · $15,961 $2,369,416
2024 $511,917 · · · $287,954 · $15,861 $2,432,507
2023 $497,007 · · · $507,838 · $15,097 $1,934,540

Figures from the Summary Compensation Table of the company's proxy statement (DEF 14A). Compensation is not a recommendation.