Insider at

04

Insider transactions

05
0 buys (P) 0 sells (S) Net: $0 + 54 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

No open-market trades on record; showing all filings.

DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
July 13, 2026 ESPR D 44,000 · · 0 Direct -100.00% Disposed
July 13, 2026 ESPR D 32,500 · · 0 Direct -100.00% Disposed
July 13, 2026 ESPR D 21,000 · · 0 Direct -100.00% Disposed
July 13, 2026 ESPR D 164,472 · · 0 Direct -100.00% Disposed
June 16, 2026 IRWD A 63,481 · · 235,036 Direct +37.00% Acquired (price as of 2026-10-02)
May 28, 2026 ESPR A 79,873 · · 164,472 Direct +94.41% Acquired
May 20, 2026 INO A 41,800 · · 41,800 Direct · Acquired (price as of 2026-10-02)
May 20, 2026 INO A 34,200 · · 34,200 Direct · Acquired (price as of 2026-10-02)
June 10, 2025 IRWD A 45,000 · · 171,555 Direct +35.56% Acquired (price as of 2026-10-02)
May 29, 2025 ESPR A 33,000 · · 84,599 Direct +63.95% Acquired
May 29, 2025 ESPR A 44,000 · · 44,000 Direct · Acquired
May 21, 2025 INO M 2,167 · · 0 Direct -100.00% Disposed (price as of 2026-10-02)
May 21, 2025 INO M 2,167 · · 9,209 Direct +30.77% Acquired (price as of 2026-10-02)
June 18, 2024 IRWD A 24,311 · · 126,555 Direct +23.78% Acquired (price as of 2026-10-02)
May 23, 2024 ESPR A 23,000 · · 51,599 Direct +80.42% Acquired
May 23, 2024 ESPR A 32,500 · · 32,500 Direct · Acquired
May 21, 2024 INO A 2,167 · · 2,167 Direct · Acquired (price as of 2026-10-02)
May 21, 2024 INO A 2,917 · · 2,917 Direct · Acquired (price as of 2026-10-02)
May 15, 2024 INO M 2,166 · · 0 Direct -100.00% Disposed (price as of 2026-10-02)
May 15, 2024 INO M 2,166 · · 7,042 Direct +44.42% Acquired (price as of 2026-10-02)
June 20, 2023 IRWD A 22,350 · · 102,244 Direct +27.97% Acquired (price as of 2026-10-02)
June 15, 2023 ESPR A 5,150 · · 28,599 Direct +21.96% Acquired
June 15, 2023 ESPR A 21,000 · · 21,000 Direct · Acquired
May 16, 2023 INO M 19,000 · · 0 Direct -100.00% Disposed (price as of 2026-10-02)
May 16, 2023 INO M 19,000 · · 58,521 Direct +48.08% Acquired (price as of 2026-10-02)
May 15, 2023 INO A 26,000 · · 26,000 Direct · Acquired (price as of 2026-10-02)
May 15, 2023 INO A 35,000 · · 35,000 Direct · Acquired (price as of 2026-10-02)
Jan. 15, 2023 INO M 4,273 · · 0 Direct -100.00% Disposed (price as of 2026-10-02)
Jan. 15, 2023 INO M 4,273 · · 39,521 Direct +12.12% Acquired (price as of 2026-10-02)
June 1, 2022 IRWD A 21,571 · · 79,894 Direct +36.99% Acquired (price as of 2026-10-02)
May 26, 2022 ESPR A 20,000 · · 20,000 Direct · Acquired
May 16, 2022 INO A 19,000 · · 19,000 Direct · Acquired (price as of 2026-10-02)
May 16, 2022 INO A 28,000 · · 28,000 Direct · Acquired (price as of 2026-10-02)
May 13, 2022 INO M 18,000 · · 35,248 Direct +104.36% Acquired (price as of 2026-10-02)
May 13, 2022 INO M 18,000 · · 0 Direct -100.00% Disposed (price as of 2026-10-02)
Jan. 15, 2022 INO M 4,274 · · 4,273 Direct -50.01% Disposed (price as of 2026-10-02)
Jan. 15, 2022 INO M 4,274 · · 17,248 Direct +32.94% Acquired (price as of 2026-10-02)
June 2, 2021 IRWD A 22,766 · · 58,323 Direct +64.03% Acquired (price as of 2026-10-02)
May 27, 2021 ESPR A 12,376 · · 23,449 Direct +111.77% Acquired
May 14, 2021 INO M 8,700 · · 0 Direct -100.00% Disposed (price as of 2026-10-02)
May 14, 2021 INO M 8,700 · · 12,974 Direct +203.56% Acquired (price as of 2026-10-02)
May 13, 2021 INO A 18,000 · · 18,000 Direct · Acquired (price as of 2026-10-02)
May 13, 2021 INO A 27,000 · · 27,000 Direct · Acquired (price as of 2026-10-02)
Jan. 15, 2021 INO M 4,274 · · 8,547 Direct -33.34% Disposed (price as of 2026-10-02)
Jan. 15, 2021 INO M 4,274 · · 4,274 Direct · Acquired (price as of 2026-10-02)
Dec. 3, 2020 IRWD A 10,830 · · 35,557 Direct +43.80% Acquired (price as of 2026-10-02)
Dec. 3, 2020 IRWD A 24,727 · · 24,727 Direct · Acquired (price as of 2026-10-02)
May 28, 2020 ESPR A 6,106 · · 11,073 Direct +122.93% Acquired
May 14, 2020 INO A 8,700 · · 8,700 Direct · Acquired (price as of 2026-10-02)
May 14, 2020 INO A 13,300 · · 13,300 Direct · Acquired (price as of 2026-10-02)
Jan. 15, 2020 INO A 20,000 · · 20,000 Direct · Acquired (price as of 2026-10-02)
Jan. 15, 2020 INO A 12,821 · · 12,821 Direct · Acquired (price as of 2026-10-02)
May 29, 2019 ESPR A 4,967 · · 4,967 Direct · Acquired
May 24, 2018 ESPR A 18,700 · · 18,700 Direct · Acquired

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
July 13, 2026 ESPR Stock Option (right to buy) Common Stock (44,000) · May 29, 2035 44,000 Disposed
July 13, 2026 ESPR Stock Option (right to buy) Common Stock (32,500) · May 23, 2034 32,500 Disposed
July 13, 2026 ESPR Stock Option (right to buy) Common Stock (21,000) · June 15, 2033 21,000 Disposed
May 20, 2026 INO Common Stock Options Common Stock (41,800) $1.23 May 20, 2036 41,800 Acquired
May 20, 2026 INO Restricted Stock Unit Common Stock (34,200) · · 34,200 Acquired
May 29, 2025 ESPR Stock Option (right to buy) Common Stock (44,000) $0.87 May 29, 2035 44,000 Acquired
May 21, 2025 INO Restricted Stock Unit Common Stock (2,167) · · 2,167 Disposed
May 23, 2024 ESPR Stock Option (right to buy) Common Stock (32,500) $2.25 May 23, 2034 32,500 Acquired
May 21, 2024 INO Restricted Stock Unit Common Stock (2,167) · · 2,167 Acquired
May 21, 2024 INO Common Stock Options Common Stock (2,917) $10.99 May 21, 2034 2,917 Acquired
May 15, 2024 INO Restricted Stock Unit Common Stock · · 2,166 Disposed
June 15, 2023 ESPR Stock Option (right to buy) Common Stock (21,000) $1.37 June 15, 2033 21,000 Acquired
May 16, 2023 INO Restricted Stock Unit Common Stock (19,000) · · 19,000 Disposed
May 15, 2023 INO Restricted Stock Unit Common Stock (26,000) · · 26,000 Acquired
May 15, 2023 INO Common Stock Options Common Stock (35,000) $0.77 May 15, 2033 35,000 Acquired
Jan. 15, 2023 INO Restricted Stock Unit Common Stock (4,273) · · 4,273 Disposed
May 26, 2022 ESPR Stock Option (right to buy) Common Stock (20,000) $5.51 May 26, 2032 20,000 Acquired
May 16, 2022 INO Restricted Stock Unit Common Stock (19,000) · · 19,000 Acquired
May 16, 2022 INO Common Stock Options Common Stock (28,000) $1.89 May 16, 2032 28,000 Acquired
May 13, 2022 INO Restricted Stock Unit Common Stock (18,000) · · 18,000 Disposed
Jan. 15, 2022 INO Restricted Stock Unit Common Stock (4,274) · · 4,274 Disposed
May 14, 2021 INO Restricted Stock Unit Common Stock (8,700) · · 8,700 Disposed
May 13, 2021 INO Restricted Stock Unit Common Stock (18,000) · · 18,000 Acquired
May 13, 2021 INO Common Stock Options Common Stock (27,000) $6.23 May 13, 2031 27,000 Acquired
Jan. 15, 2021 INO Restricted Stock Unit Common Stock (4,274) · · 4,274 Disposed
May 14, 2020 INO Restricted Stock Unit Common Stock (8,700) · · 8,700 Acquired
May 14, 2020 INO Common Stock Options Common Stock (13,300) $13.65 May 14, 2030 13,300 Acquired
Jan. 15, 2020 INO Common Stock Option Common Stock (20,000) $3.35 Jan. 15, 2030 20,000 Acquired
Jan. 15, 2020 INO Restricted Stock Unit Common Stock (12,821) · · 12,821 Acquired
May 24, 2018 ESPR Stock Option (right to buy) Common Stock (18,700) $37.69 May 24, 2028 18,700 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).