IRWD Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $3.46
Market Cap (MRQ) $572M
P/E (TTM) 4.5
EPS (TTM) $0.77
Revenue (TTM) $389M
ROE (TTM) -55.3%
52W Range $1–$6

IRWD Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

04
range
bars

Bar granularity adapts to the selected period — hover the chart to see open/high/low/close for a bar.

Stock splits 1
Ex-date Split Type
April 2, 2019 597-for-500 Forward

About Ironwood Pharmaceuticals, Inc. - Class A Common Stock Company overview from Wikipedia

05 · wikidata

Ironwood Pharmaceuticals, Inc. is a publicly traded pharmaceutical company. It was originally called Microbia, Inc.

Microbia was founded by postdocs from the lab of Gerald Fink at the Whitehead Institute to commercialize approaches that had been developed in the lab to improve industrial fermentation of fungi, to genetically engineer them to produce secondary metabolites more efficiently or to produce new ones as leads for drug discovery or as products for use in industry, and to identify drug targets in fungi for antifungal drug discovery. In 2002 the company hired John Talley to lead their antifungal drug discovery efforts, which at the time were focused on identifying small molecules that could inhibit fungal invasins, along with Mark Currie who had also worked at Searle division of Monsanto with Talley, and then had gone to Sepracor, and also Richard Bailey, who had run Monsanto's nutritional business. Currie directed the efforts that led to the discovery of linaclotide, which was based on an enterotoxin produced by some strains of Escherichia coli that cause traveler's diarrhea.

By 2004 the company had raised $99M and was preparing a Phase I trial for linaclotide. By 2006 Microbia was starting to struggle with the different challenges and expenses of drug development, along with its industrial fermentation business and drug discovery efforts, and made the decision to split in two, with "Microbia Precision Engineering" focused on industrial applications led by Bailey and Microbia focused on drug discovery and development. Tate & Lyle invested $7M in the Microbia spinout and took a board seat in 2006. Microbia changed its name to Ironwood in 2008 and shortened the name of the industrial business to Microbia.

By 2009, Ironwood had raised a total of $281M. In early 2010 Ironwood held its IPO, which priced at $11.25 a share, below the target price of $14. Later that year it sold its interests in Microbia to DSM for an undisclosed sum.

Linaclotide (Linzess in the US and Mexico, and as Constella elsewhere), a drug used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause, was approved in the US and Europe in 2012. Most of the marketing rights were licensed to Allergan and Astellas.

It was developing a drug called IW-9179 or recanaclotide but abandoned it in 2016.

Soclenicant (BNC-210; IW-2143) is an anxiolytic that Ironwood licensed and performed R&D on and then abandoned.

In April 2018, the shares of Ironwood Pharmaceuticals closed up more than 10 percent on the news of biotech activist investor, Alex Denner joining its board.

Despite having a billion dollar drug in Linzess, Ironwood - through a series of confounding decisions by management - has seen its stock price crater from a high of $21.16 on July 17, 2018, to its current price of 77 CENTS at the close of trading on August 1, 2025.

== References ==

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

sectorHealthcare industryBiotechnology employees100 countryUS

10-Year Performance Revenue, net income, margins and EPS trends

06
Revenue$296M
2016-12-31 → 2025-12-31
EPS$0.15
2018-12-31 → 2025-12-31
Free Cash Flow$127M
2016-12-31 → 2025-12-31
Net margin33.4%
2018-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend IRWD 5Y avg Peer Median Verdict
P/E (TTM) 4.55Y avg ≈96.0 ≈96.0 · ·
P/S (TTM) 1.55Y avg ≈3.4 ≈3.4 1.8 Fair value
P/B (MRQ) -3.55Y avg ≈-0.7 ≈-0.7 · ·
Price / FCF 4.45Y avg ≈7.0 ≈7.0 · ·
Price / Cash Flow 4.45Y avg ≈7.0 ≈7.0 13.5 Undervalued
Price / Tangible Book (MRQ) -3.5 · · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise -5.1%
Next Report Nov 09, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 6, 2026 $0.31 $0.36 -14.6%
March 31, 2026 $0.24 $0.24 -2.0%
Dec. 31, 2025 $-0.01 $0.01 -198.0%
Sept. 30, 2025 $0.24 $0.10 135.3%
June 30, 2025 $0.14 $0.04 243.1%
March 31, 2025 $-0.14 $-0.05 -194.1%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

15
Income Statement 16
Metric Trend 202520242023202220212020201920182017201620152014
Revenue $296M$351M$443M$411M$414M$390M$428M$347M$298M$274M$150M$76M
Cost of Revenue ·····$3M$24M$33M$19M$2M$12.0K$5M
R&D Expense $95M$111M$116M$44M$70M$88M$115M$101M$88M$139M$109M$102M
SG&A Expense $82M$144M$158M$116M$111M$140M$172M$220M$231M$173M$125M$118M
Operating Expenses $198M$258M$1.39B$160M$181M$247M$308M$497M$314M$326M$252M$246M
Operating Income $99M$93M$-945M$250M$232M$143M$120M$-151M$-15M$-52M$-102M$-169M
Interest Expense ··$22M$8M$31M$29M$37M$38M$36M$39M$31M$21M
Other Non-op $193.0K$640.0K$-3M$2M$-32M$-34M$-61M$-43M$-40M$-30M$-41M$-20M
Pretax Income $70M$65M$-948M$252M$201M$109M$59M$-194M····
Income Tax $46M$64M$83M$77M$-328M$3M$0$0$0$0$0$0
Net Income $24M$880.0K$-1.00B$175M$528M$106M$22M$-282M$-117M$-82M$-143M·
EPS (Basic) $0.15$0.01$-6.45$1.13$3.26$0.67$0.14$-1.85····
EPS (Diluted) $0.15$0.01$-6.45$0.96$3.21$0.66$0.14$-1.85····
Shares (Basic) 161,842,000159,083,000155,435,000154,366,000162,245,000159,427,000156,023,000152,634,000····
Shares (Diluted) 162,983,000160,084,000155,435,000186,312,000164,418,000160,655,000156,023,000152,634,000····
EBITDA $100M$94M$-944M$252M$234M$145M$126M$-233M·$-42M$-90M$-157M
Balance Sheet 28
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents $215M$89M$92M$656M$620M$363M$177M$173M$126M$54M$261M$74M
Short-term Investments ········$96M$251M$178M$174M
Receivables $47M$82M$129M$115M$114M$122M$11M$21M$3M$933.0K$3M$10.0K
Inventory ······$648.0K·$735.0K$1M·$5M
Prepaid Expense $12M$12M$12M$8M$9M$9M$11M$10M$7M$9M$6M$9M
Current Assets $274M$182M$233M$781M$745M$496M$307M$266M$312M$380M$500M$288M
PP&E (Net) $3M$4M$6M$6M$8M$9M$12M$8M$17M$21M$21M$30M
PP&E (Gross) $11M$13M$14M$17M$17M$21M$23M$33M$86M$83M$78M$83M
Accum. Depreciation $8M$8M$9M$11M$10M$12M$10M$26M$69M$62M$57M$53M
Goodwill ······$785.0K$785.0K$785.0K$785.0K··
Intangibles $2M$3M$4M·····$160M$166M··
Other Non-current Assets $5M$6M$4M$847.0K$1M$943.0K$790.0K$89.0K$870.0K$1M$3M$3M
Total Assets $397M$351M$471M$1.10B$1.13B$559M$403M$332M$606M$710M$619M$329M
Accounts Payable $3M$2M$8M$483.0K$935.0K$661.0K$4M$15M$16M$18M$9M$10M
Accrued Liabilities ·········$38M$23M$23M
Short-term Debt ·······$48M··$25M$11M
Current Liabilities $242M$39M$276M$26M$162M$32M$41M$120M$66M$91M$76M$61M
Capital Leases $10M$12M$15M$17M$18M$20M$22M$158.0K·$82.0K$306.0K$3M
Other Non-current Liabilities $22M$17M$28M$10M$4M$2M$734.0K$3M$5M$8M$10M·
Total Liabilities $659M···········
Long-term Debt ·$199M$398M$396M$454M$430M····$221M·
Total Debt ·······$48M··$25M$11M
Common Stock $163.0K$160.0K$156.0K$154.0K$162.0K$161.0K$158.0K$154.0K····
Retained Earnings $-1.67B$-1.70B$-1.70B$-696M$-938M$-1.47B$-1.57B$-1.59B$-1.31B$-1.19B$-1.11B$-967M
AOCI $-1M$923.0K$-3M·····$-79.0K$-7.0K$-86.0K$-19.0K
Stockholders' Equity $-262M$-301M$-346M$652M$606M$63M$-93M$-196M$10M$67M$95M$89M
Liabilities + Equity $397M$351M$471M$1.10B$1.13B$559M$403M$332M$606M$710M$619M$329M
Shares Outstanding 163,058,316160,205,899156,354,238154,026,949162,036,461160,616,675157,535,962154,414,691····
Cash Flow 18
Metric Trend 202520242023202220212020201920182017201620152014
D&A $1M$1M$1M$1M$2M$2M$6M$4M$6M$10M$12M$12M
Stock-based Comp $17M$30M$32M$27M$22M$31M$31M$41M$31M$29M$25M$26M
Deferred Tax $41M$68M$73M$66M$-333M·······
Amort. of Intangibles ·······$8M$6M$981.0K··
Restructuring $21M$3M$17M·$1M$15M$4M$15M···$551.0K
Other Non-cash $44M$4M$1.08B$5M$43M$29M$-48M$161M····
Operating Cash Flow $127M$104M$183M$274M$262M$169M$11M$-71M$-101M$-26M$-107M$-156M
CapEx $34.0K$142.0K$273.0K$136.0K$265.0K$2M$7M$351.0K$3M$4M$4M$4M
Investing Cash Flow $-34.0K$-142.0K$-1.03B$-136.0K$-265.0K$-2M$-11M$89M$151M$-178M$-9M$-57M
Debt Issued ········$146M···
Stock Issued ···········$190M
Stock Repurchased ···$126M$24M·······
Net Stock Activity ···$-126M$-24M······$190M
Financing Cash Flow $216.0K$-107M$277M$-238M$-5M$19M$-1M$30M$20M$-4M$303M$211M
Net Change in Cash $127M$-4M$-566M$36M$257M$186M$-2M$48M$71M$-208M$187M·
Taxes Paid $4M$8M$10M$5M$3M$2M······
Free Cash Flow $127M$103M$183M$274M$262M$167M$4M$-80M·$-30M$-111M$-159M
Levered FCF ··$160M$268M$180M$138M······
Profitability 7
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 33.3%26.5%-213.5%61.0%56.1%36.7%28.0%-68.9%·-18.9%-68.3%-221.6%
Net Margin 8.1%0.25%-226.4%42.6%127.7%27.3%5.0%-81.5%····
Pretax Margin 23.6%18.6%-214.1%61.5%48.5%28.0%······
EBITDA Margin 33.6%26.8%-213.3%61.3%56.5%37.3%29.3%-67.2%·-15.2%-60.5%-205.4%
ROA 6.4%0.21%-127.5%15.7%62.7%22.1%5.9%-60.2%····
ROE -8.5%-0.27%-654.9%29.9%94.6%309.8%-17.5%143.5%····
ROIC -12.9%-0.42%297.1%26.6%101.0%222.6%······
Liquidity & Solvency 4
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 1.14.70.830.64.615.47.52.2·4.26.54.8
Quick Ratio 1.14.40.830.24.515.14.61.6·3.45.84.1
Debt / Equity ·······-0.2··0.30.1
Interest Coverage ··-43.732.97.54.83.3-6.3·-1.3-3.3-8.0
Efficiency 3
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 0.80.90.60.40.50.81.20.7·0.40.30.2
Inventory Turnover ······34.5··3.5·1.9
Receivables Turnover 4.63.33.63.63.55.826.628.7·143.5103.4292.3
Per Share 5
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share $-1.61$-1.88$-2.21$4.24$3.74$0.39$-0.59·····
Revenue / Share $1.82$2.20$2.85$2.20$2.52$2.42······
Cash Flow / Share $0.78$0.65$1.18$1.47$1.59$1.05······
Cash / Share $1.32$0.55$0.59$4.26$3.83$2.26$1.12·····
EPS (TTM) $0.15$0.01$-6.45$0.96$3.21$0.66$0.14$-1.85$-2.38$-2.38$-2.38$-2.38
Growth Rates 9
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY -15.7%-20.6%7.8%-0.76%6.2%·······
Revenue CAGR 3Y -10.3%-5.3%4.4%·········
Revenue CAGR 5Y -5.3%···········
EPS YoY 1400.0%··-70.1%386.4%·······
EPS CAGR 3Y -46.1%-85.4%··········
EPS CAGR 5Y -25.7%···········
Net Income YoY 2629.2%··-66.9%397.7%·······
Net Income CAGR 3Y -48.4%-88.1%··········
Net Income CAGR 5Y -25.7%···········
Valuation (TTM) 10
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM $296M$351M$443M$411M$414M$390M$428M$347M$298M$274M$150M$76M
Net Income TTM $24M$880.0K$-1.00B$175M$528M$106M$22M$-282M$-117M$-82M$-143M·
Market Cap $550M$710M$1.79B$1.91B$1.89B$1.83B$2.10B·····
P/E 22.5443.0-1.812.93.617.395.1-4.7-5.3-5.4-4.1-5.4
P/S 1.92.04.04.64.64.74.9·····
P/B -2.1-2.4-5.22.93.129.2-22.5·····
P / Tangible Book ···2.93.129.2······
P / Cash Flow 4.36.99.87.07.210.8195.5·····
P / FCF 4.36.99.87.07.211.0593.0·····
Earnings Yield 4.5%0.23%-56.4%7.8%27.5%5.8%1.1%-21.3%-19.0%-18.6%-24.5%-18.6%

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

16
Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $296M $351M $443M $411M $414M
Operating Margin % 33.3% 26.5% -213.5% 61.0% 56.1%
Net Income $24M $880.0K $-1.00B $175M $528M
Diluted EPS $0.15 $0.01 $-6.45 $0.96 $3.21

Institutional owners (13F) 234 filers · $707.9M total · As of Sept. 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 234
Value held $707.9M
New positions 25
Exited positions 32
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
25 (-35 vs prior Q) 32 (+7 vs prior Q) 76 (-10 vs prior Q) 86 (+31 vs prior Q) -10.7M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
BlackRock, Inc. $74,889,826 17,788,557 10.58% Shares
ARMISTICE CAPITAL, LLC $58,653,720 13,932,000 8.29% Shares
VANGUARD GROUP INC $53,779,120 15,958,196 7.60% Shares
Sarissa Capital Management LP $38,684,153 9,188,635 5.46% Shares
STATE STREET CORP $37,088,420 8,809,601 5.24% Shares
BANK OF AMERICA CORP /DE/ $36,558,810 8,683,803 5.16% Shares
RENAISSANCE TECHNOLOGIES LLC $33,651,481 7,993,226 4.75% Shares
VANGUARD CAPITAL MANAGEMENT LLC $27,821,819 6,608,508 3.93% Shares
AQR CAPITAL MANAGEMENT LLC $27,221,528 6,465,921 3.85% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $23,211,225 5,513,355 3.28% Shares
GEODE CAPITAL MANAGEMENT, LLC $20,345,036 4,831,657 2.87% Shares
TWO SIGMA INVESTMENTS, LP $19,181,135 4,556,089 2.71% Shares
MARSHALL WACE, LLP $18,061,293 4,290,093 2.55% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $17,117,708 4,065,964 2.42% Shares
GOLDMAN SACHS GROUP INC $13,951,132 3,313,808 1.97% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $13,902,439 3,302,242 1.96% Shares
FEDERATED HERMES, INC. $13,603,512 3,231,238 1.92% Shares
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $12,701,945 3,017,089 1.79% Shares
DIMENSIONAL FUND ADVISORS LP $10,622,431 2,522,891 1.50% Shares
TWO SIGMA ADVISERS, LP $10,582,137 3,140,100 1.49% Shares
MACKENZIE FINANCIAL CORP $9,967,146 2,367,493 1.41% Shares
MORGAN STANLEY $7,830,240 1,859,914 1.11% Shares
Connor, Clark & Lunn Investment Management Ltd. $7,627,316 1,811,714 1.08% Shares
NORTHERN TRUST CORP $5,784,430 1,373,974 0.82% Shares
Hillsdale Investment Management Inc. $5,264,302 1,250,428 0.74% Shares
WELLS FARGO & COMPANY/MN $5,078,094 1,206,198 0.72% Shares
DEUTSCHE BANK AG\ $4,875,761 1,158,138 0.69% Shares
VANGUARD FIDUCIARY TRUST CO $4,379,810 1,040,335 0.62% Shares
FRANKLIN RESOURCES INC $4,239,382 1,006,979 0.60% Shares
FMR LLC $3,828,942 909,488 0.54% Shares
STATE OF WISCONSIN INVESTMENT BOARD $3,277,548 778,515 0.46% Shares
RAYMOND JAMES FINANCIAL INC $3,052,608 725,085 0.43% Shares
VICTORY CAPITAL MANAGEMENT INC $2,772,104 658,457 0.39% Shares
IEQ CAPITAL, LLC $2,364,286 561,588 0.33% Shares
Vanguard Global Advisers, LLC $2,361,970 561,038 0.33% Shares
PRUDENTIAL FINANCIAL INC $2,261,608 537,199 0.32% Shares
Bank of New York Mellon Corp $2,142,384 508,880 0.30% Shares
CITADEL ADVISORS LLC $2,115,117 502,403 0.30% Shares
VOYA INVESTMENT MANAGEMENT LLC $2,039,535 484,450 0.29% Shares
CWA Asset Management Group, LLC $1,979,613 498,643 0.28% Shares
WELLINGTON MANAGEMENT GROUP LLP $1,973,737 468,821 0.28% Shares
SEI INVESTMENTS CO $1,934,150 459,417 0.27% Shares
O'SHAUGHNESSY ASSET MANAGEMENT, LLC $1,847,815 438,911 0.26% Shares
WEDGE CAPITAL MANAGEMENT L L P/NC $1,729,531 435,650 0.24% Shares
SEGALL BRYANT & HAMILL, LLC $1,717,949 408,064 0.24% Shares
Invesco Ltd. $1,697,510 403,209 0.24% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,670,528 396,800 0.24% Put option
Man Group plc $1,650,813 392,117 0.23% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $1,641,029 389,793 0.23% Shares
UBS Group AG $1,639,917 389,529 0.23% Shares

Show all 234 institutional owners →

Activists & 5%+ owners 4 positions

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Sarissa Capital Management LP, Alexander J. Denner March 19, 2026 5.80% Amendment · SEC
Ironwood Pharmaceuticals, Inc. July 7, 2023 · Initial filing M&A / sale SEC
OR ×3 filings March 1, 2021 · Initial filing · SEC
Nov. 9, 2020 · Initial filing · SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 41 insiders · 18 officers · 22 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Thomas A Mccourt Chief Executive Officer March 10, 2026 A 1,898,838 0 2 $-739,929
Mark Mallon Chief Executive Officer Feb. 26, 2021 S 470,605 0 0 $0
Peter M. Hecht Chief Executive Officer April 1, 2019 D 2,217,366 0 0 $0
Gregory S. Martini Chief Financial Officer March 10, 2026 A 297,213 0 2 $-81,888
Sravan Kumar Emany SVP, COO and CFO Nov. 18, 2024 S 309,572 0 0 $0
Gina Consylman SVP, CFO & Treasurer March 26, 2021 A 392,616 0 0 $0
Jason Rickard SVP, Chief Operating Officer March 8, 2023 A 376,316 0 0 $0
William Huyett Chief Operating Officer April 1, 2019 D 27,546 0 0 $0
Michael J Higgins Chief Operating Officer Dec. 23, 2014 M 329,102 0 0 $0
Jeffrey Silber SVP, CMO, Head-Res&Drug July 20, 2026 A 137,036 0 0 $0
Ronald Silver PFO & PAO July 7, 2026 S 313,680 0 4 $-831,183
Tammi L Gaskins Chief Commercial Officer March 10, 2026 A 350,350 0 3 $-100,301
Minardo John Chief Legal Officer March 10, 2026 A 500,498 0 2 $-136,177
Michael Shetzline SVP, CMO, Head-Res&Drug March 10, 2026 A 658,037 0 2 $-121,586
Andrew Davis SVP, Chief Business Officer Nov. 18, 2024 S 284,685 0 0 $0
Conor Kilroy SVP, GC & Secretary Feb. 26, 2021 S 122,336 0 0 $0
Kelly Macdonald Chief Accounting Officer Dec. 4, 2020 M 93,041 0 0 $0
Halley E Gilbert Chief Admin Officer & SVP Feb. 21, 2020 S 265,991 0 0 $0
DENNER ALEXANDER J Director Sept. 15, 2026 A 327,549 0 2 $-20,530,448
Catherine Moukheibir Director June 16, 2026 A 181,425 0 0 $0
Jon R Duane Director June 16, 2026 A 253,820 0 0 $0
Marla L Kessler Director June 16, 2026 A 229,364 0 0 $0
Jay Shepard Director June 16, 2026 A 235,036 0 0 $0
Julie Mchugh Director June 16, 2026 S 250,749 0 1 $-80,460
Mark G Currie Director June 16, 2026 A 676,900 0 0 $0
Andrew Dreyfus Director June 10, 2025 A 228,313 0 0 $0
Edward P Owens Director June 2, 2021 A 241,720 0 0 $0
Lawrence S Olanoff Director June 2, 2021 A 91,395 0 0 $0
Amy Schulman Director April 1, 2019 D 38,242 0 0 $0
Marsha Fanucci Director April 1, 2019 D 132,663 0 0 $0
Douglas E Williams Director April 1, 2019 D 87,800 0 0 $0
Terrance McGuire Director April 1, 2019 D 73,630 0 0 $0
WALSH CHRISTOPHER T PHD Director March 15, 2017 A 71,499 0 0 $0
George N Conrades Director June 3, 2015 A 62,221 0 0 $0
David A Ebersman Director March 13, 2015 A 29,714 0 0 $0
COOK JOSEPH C JR Director March 12, 2015 S 304,080 0 0 $0
David Evans Shaw Director March 14, 2014 A 64,306 0 0 $0
VR Management LLC 10% owner Jan. 15, 2013 J 2,442 0 0 $0
FMR LLC 10% owner July 10, 2012 S 2,340,891 0 0 $0
Thomas Graney · Feb. 27, 2017 A 42,013 0 0 $0
Bryan E Roberts · June 15, 2015 A 31,951 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 33 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
BBP · ETFis Series Trust I 1.60% 371,823 NS July 31, 2026 N-PORT
QQQS · Invesco Exchange-Traded Fund Trust … 0.48% 27,170 SH Oct. 23, 2026 Daily
LABU · Direxion Shares ETF Trust 0.16% 186,886 NS July 31, 2026 N-PORT
IWC · iShares Trust 0.15% 554,146 SH Sept. 11, 2026 Daily
VFVA · VANGUARD WELLINGTON FUND 0.13% 267,285 SH Aug. 19, 2026 Daily
CALF · Pacer Funds Trust 0.12% 1,079,411 NS July 31, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.11% 521,040 SH Aug. 19, 2026 Daily
JPSE · J.P. Morgan Exchange-Traded Fund Tr… 0.10% 135,991 NS July 31, 2026 N-PORT
FSMD · FIDELITY COVINGTON TRUST 0.08% 466,785 NS July 31, 2026 N-PORT
IBB · iShares Trust 0.05% 1,214,535 SH Sept. 11, 2026 Daily
PWS · Pacer Funds Trust 0.04% 2,553 NS July 31, 2026 N-PORT
IWO · iShares Trust 0.04% 1,446,914 SH Sept. 11, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.04% 165,563 SH Aug. 19, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.04% 12,406 SH Oct. 23, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.04% 279,233 SH Oct. 23, 2026 Daily
RSSL · Global X Funds 0.02% 78,252 NS July 31, 2026 N-PORT
IWM · iShares Trust 0.02% 4,241,422 SH Sept. 11, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.02% 943,404 SH Aug. 19, 2026 Daily
DFAS · Dimensional ETF Trust 0.01% 534,999 NS July 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.01% 1,677,357 SH Aug. 19, 2026 Daily
VHT · VANGUARD WORLD FUND 0.01% 437,643 SH Aug. 19, 2026 Daily
DFAC · Dimensional ETF Trust 0.00% 272,518 NS July 31, 2026 N-PORT
DFSU · Dimensional ETF Trust 0.00% 8,700 NS July 31, 2026 N-PORT
DCOR · Dimensional ETF Trust 0.00% 11,833 NS July 31, 2026 N-PORT
ITOT · iShares Trust 0.00% 197,587 SH Sept. 11, 2026 Daily
IWV · iShares Trust 0.00% 41,467 SH Sept. 9, 2026 Daily
DFUS · Dimensional ETF Trust 0.00% 32,200 NS July 31, 2026 N-PORT
DFAU · Dimensional ETF Trust 0.00% 11,941 NS July 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.00% 4,781,484 SH Aug. 19, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.00% 9,494 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 13,354 SH Aug. 19, 2026 Daily
IWN · iShares Trust · 92,403 SH Sept. 11, 2026 Daily
SMLF · iShares Trust · 383,496 SH Sept. 11, 2026 Daily

IRWD Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 10 analysts BUY
Median target $5.35 +54.6%
2 20.0% Strong Buy
5 50.0% Buy
3 30.0% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

4 analysts · 2026-10-21

Mean target $6.10 +76.3%

← Below all targets Current price $3.46
Low$3.70 Mean$6.10 High$10.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
IRWD $550M 22.5 -15.7% 8.1% -8.5% ·
SLDB $445M -2.8 · · -79.5% ·
GYRE $645M 353.0 10.2% 8.5% 11.7% ·
CADL $310M -7.8 · · -53.7% ·
FDMT $432M -3.1 230194.6% -164.4% -30.2% ·
CLYM $191M -4.5 · · -34.6% ·
PBYI $300M 9.8 -0.91% 13.6% 26.5% ·
MDXG $1.00B 21.2 20.0% 11.6% 20.5% 82.6%
ETRA · · · · · ·
OLMA $2.03B -13.4 · · -39.4% ·
STTK $231M -5.2 -82.5% -4880.9% -70.0% ·

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

Pick the metrics that matter to you — click the + next to any row in Full Fundamentals above.

Your selection is saved and follows you across all tickers.

Source: SEC 10-Q filed Aug 6, 2026