IRWD Ironwood Pharmaceuticals, Inc. - Class A Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$4.17
Price · Aug 24, 2026
Fundamentals as of Aug 6, 2026

About Ironwood Pharmaceuticals, Inc. - Class A Common Stock Company overview from Wikipedia

Ironwood Pharmaceuticals, Inc. is a publicly traded pharmaceutical company. It was originally called Microbia, Inc.

Read more

Ironwood Pharmaceuticals, Inc. is a publicly traded pharmaceutical company. It was originally called Microbia, Inc.

Microbia was founded by postdocs from the lab of Gerald Fink at the Whitehead Institute to commercialize approaches that had been developed in the lab to improve industrial fermentation of fungi, to genetically engineer them to produce secondary metabolites more efficiently or to produce new ones as leads for drug discovery or as products for use in industry, and to identify drug targets in fungi for antifungal drug discovery. In 2002 the company hired John Talley to lead their antifungal drug discovery efforts, which at the time were focused on identifying small molecules that could inhibit fungal invasins, along with Mark Currie who had also worked at Searle division of Monsanto with Talley, and then had gone to Sepracor, and also Richard Bailey, who had run Monsanto's nutritional business. Currie directed the efforts that led to the discovery of linaclotide, which was based on an enterotoxin produced by some strains of Escherichia coli that cause traveler’s diarrhea.

By 2004 the company had raised $99M and was preparing a Phase I trial for linaclotide. By 2006 Microbia was starting to struggle with the different challenges and expenses of drug development, along with its industrial fermentation business and drug discovery efforts, and made the decision to split in two, with "Microbia Precision Engineering" focused on industrial applications led by Bailey and Microbia focused on drug discovery and development. Tate & Lyle invested $7M in the Microbia spinout and took a board seat in 2006. Microbia changed its name to Ironwood in 2008 and shortened the name of the industrial business to Microbia.

By 2009, Ironwood had raised a total of $281M. In early 2010 Ironwood held its IPO, which priced at $11.25 a share, below the target price of $14. Later that year it sold its interests in Microbia to DSM for an undisclosed sum.

Linaclotide (Linzess in the US and Mexico, and as Constella elsewhere), a drug used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause, was approved in the US and Europe in 2012. Most of the marketing rights were licensed to Allergan and Astellas.

It was developing a drug called IW-9179 or recanaclotide but abandoned it in 2016.

Soclenicant (BNC-210; IW-2143) is an anxiolytic that Ironwood licensed and performed R&D on and then abandoned.

In April 2018, the shares of Ironwood Pharmaceuticals closed up more than 10 percent on the news of biotech activist investor, Alex Denner joining its board.

Despite having a billion dollar drug in Linzess, Ironwood - through a series of confounding decisions by management - has seen its stock price crater from a high of $21.16 on July 17, 2018, to its current price of 77 CENTS at the close of trading on August 1, 2025.

== References ==

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

IRWD Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$4.17
Market Cap
$679M
P/E (TTM)
27.8
EPS (TTM)
$0.15
Revenue (TTM)
$296M
Div Yield
ROE
-8.5%
Debt/Equity
52W Range
$1 – $6

IRWD Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $296M
10-point trend, +8.1%
2016-12-31 2025-12-31
EPS $0.15
8-point trend, +108.1%
2018-12-31 2025-12-31
Free Cash Flow $127M
9-point trend, +528.5%
2016-12-31 2025-12-31
Margins 8.1%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
IRWD
Peer Median
P/E (TTM)
5-point trend, +518.5%
27.8
70.4
P/S (TTM)
5-point trend, -59.4%
2.3
8.3
P/B
5-point trend, -167.3%
-2.6
2.2
Price / FCF
5-point trend, -40.1%
5.3

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
IRWD
Peer Median
Operating Margin
5-point trend, -40.7%
33.3%
Net Profit Margin
5-point trend, -93.7%
8.1%
-330.2%
ROA
5-point trend, -89.8%
6.4%
-35.6%
ROE
5-point trend, -109.0%
-8.5%
-37.4%
ROIC
5-point trend, -112.8%
-12.9%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
IRWD
Peer Median
Current Ratio
5-point trend, -75.4%
1.1
7.1
Quick Ratio
5-point trend, -76.2%
1.1

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
IRWD
Peer Median
Revenue YoY
5-point trend, -28.4%
-15.7%
Revenue CAGR 3Y
5-point trend, -28.4%
-10.3%
Revenue CAGR 5Y
5-point trend, -28.4%
-5.3%
EPS YoY
5-point trend, -95.3%
1400.0%
Net Income YoY
5-point trend, -95.5%
2629.2%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
IRWD
Peer Median
EPS (Diluted)
5-point trend, -95.3%
$0.15

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
IRWD
Peer Median

IRWD Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 10 analysts
  • Strong Buy 2 20.0%
  • Buy 5 50.0%
  • Hold 3 30.0%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

4 analysts · 2026-08-19
Median target $5.35 +28.5%
Mean target $6.10 +46.5%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.01%
Period EPS Actual EPS Est Surprise
June 30, 2026 $0.31 $0.36 -0.05%
March 31, 2026 $0.24 $0.24 -0.00%
Dec. 31, 2025 $-0.01 $0.01 -0.02%
Sept. 30, 2025 $0.24 $0.10 0.14%
June 30, 2025 $0.14 $0.04 0.10%
March 31, 2025 $-0.14 $-0.05 -0.09%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
IRWD $550M 22.5 -15.7% 8.1% -8.5%
RGNX $733M -3.8 104.5% -113.8% -122.5%
MNPR
ASMB $539M -61.8 153.5% -8.5% -5.5%
EIKN
SGMT -3.7 -42.3%
MDXG $1.00B 21.2 20.0% 11.6% 20.5% 82.6%
PRME $626M -2.6 55.3% -4342.4% -221.4%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for IRWD
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +287.4% $296M $351M $443M $411M $414M $390M $428M $347M $298M $274M $150M $76M
Cost of Revenue 7-point trend, -40.7% · · · · · $3M $24M $33M $19M $2M $12.0K $5M
R&D Expense 12-point trend, -6.6% $95M $111M $116M $44M $70M $88M $115M $101M $88M $139M $109M $102M
SG&A Expense 12-point trend, -30.5% $82M $144M $158M $116M $111M $140M $172M $220M $231M $173M $125M $118M
Operating Expenses 12-point trend, -19.6% $198M $258M $1.39B $160M $181M $247M $308M $497M $314M $326M $252M $246M
Operating Income 12-point trend, +158.2% $99M $93M $-945M $250M $232M $143M $120M $-151M $-15M $-52M $-102M $-169M
Interest Expense 10-point trend, +2.2% · · $22M $8M $31M $29M $37M $38M $36M $39M $31M $21M
Other Non-op 12-point trend, +101.0% $193.0K $640.0K $-3M $2M $-32M $-34M $-61M $-43M $-40M $-30M $-41M $-20M
Pretax Income 8-point trend, +136.1% $70M $65M $-948M $252M $201M $109M $59M $-194M · · · ·
Income Tax 12-point trend, +46008000.00 $46M $64M $83M $77M $-328M $3M $0 $0 $0 $0 $0 $0
Net Income 11-point trend, +116.8% $24M $880.0K $-1.00B $175M $528M $106M $22M $-282M $-117M $-82M $-143M ·
EPS (Basic) 8-point trend, +108.1% $0.15 $0.01 $-6.45 $1.13 $3.26 $0.67 $0.14 $-1.85 · · · ·
EPS (Diluted) 8-point trend, +108.1% $0.15 $0.01 $-6.45 $0.96 $3.21 $0.66 $0.14 $-1.85 · · · ·
Shares (Basic) 8-point trend, +6.0% 161,842,000 159,083,000 155,435,000 154,366,000 162,245,000 159,427,000 156,023,000 152,634,000 · · · ·
Shares (Diluted) 8-point trend, +6.8% 162,983,000 160,084,000 155,435,000 186,312,000 164,418,000 160,655,000 156,023,000 152,634,000 · · · ·
EBITDA 11-point trend, +163.4% $100M $94M $-944M $252M $234M $145M $126M $-233M · $-42M $-90M $-157M
Balance Sheet 28
Annual Balance Sheet data for IRWD
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +190.0% $215M $89M $92M $656M $620M $363M $177M $173M $126M $54M $261M $74M
Short-term Investments 4-point trend, -45.0% · · · · · · · · $96M $251M $178M $174M
Receivables 12-point trend, +467350.0% $47M $82M $129M $115M $114M $122M $11M $21M $3M $933.0K $3M $10.0K
Inventory 4-point trend, -87.0% · · · · · · $648.0K · $735.0K $1M · $5M
Prepaid Expense 12-point trend, +30.5% $12M $12M $12M $8M $9M $9M $11M $10M $7M $9M $6M $9M
Current Assets 12-point trend, -4.9% $274M $182M $233M $781M $745M $496M $307M $266M $312M $380M $500M $288M
PP&E (Net) 12-point trend, -88.6% $3M $4M $6M $6M $8M $9M $12M $8M $17M $21M $21M $30M
PP&E (Gross) 12-point trend, -86.2% $11M $13M $14M $17M $17M $21M $23M $33M $86M $83M $78M $83M
Accum. Depreciation 12-point trend, -84.9% $8M $8M $9M $11M $10M $12M $10M $26M $69M $62M $57M $53M
Goodwill Flat — no change across 4 periods · · · · · · $785.0K $785.0K $785.0K $785.0K · ·
Intangibles 5-point trend, -98.8% $2M $3M $4M · · · · · $160M $166M · ·
Other Non-current Assets 12-point trend, +48.0% $5M $6M $4M $847.0K $1M $943.0K $790.0K $89.0K $870.0K $1M $3M $3M
Total Assets 12-point trend, +20.5% $397M $351M $471M $1.10B $1.13B $559M $403M $332M $606M $710M $619M $329M
Accounts Payable 12-point trend, -70.3% $3M $2M $8M $483.0K $935.0K $661.0K $4M $15M $16M $18M $9M $10M
Accrued Liabilities 3-point trend, +69.4% · · · · · · · · · $38M $23M $23M
Short-term Debt 3-point trend, +322.4% · · · · · · · $48M · · $25M $11M
Current Liabilities 12-point trend, +300.1% $242M $39M $276M $26M $162M $32M $41M $120M $66M $91M $76M $61M
Capital Leases 11-point trend, +283.9% $10M $12M $15M $17M $18M $20M $22M $158.0K · $82.0K $306.0K $3M
Other Non-current Liabilities 11-point trend, +113.9% $22M $17M $28M $10M $4M $2M $734.0K $3M $5M $8M $10M ·
Total Liabilities $659M · · · · · · · · · · ·
Long-term Debt 6-point trend, -9.8% · $199M $398M $396M $454M $430M · · · · $221M ·
Total Debt 3-point trend, +322.4% · · · · · · · $48M · · $25M $11M
Common Stock 8-point trend, +5.8% $163.0K $160.0K $156.0K $154.0K $162.0K $161.0K $158.0K $154.0K · · · ·
Retained Earnings 12-point trend, -73.0% $-1.67B $-1.70B $-1.70B $-696M $-938M $-1.47B $-1.57B $-1.59B $-1.31B $-1.19B $-1.11B $-967M
AOCI 7-point trend, -5478.9% $-1M $923.0K $-3M · · · · · $-79.0K $-7.0K $-86.0K $-19.0K
Stockholders' Equity 12-point trend, -395.7% $-262M $-301M $-346M $652M $606M $63M $-93M $-196M $10M $67M $95M $89M
Liabilities + Equity 12-point trend, +20.5% $397M $351M $471M $1.10B $1.13B $559M $403M $332M $606M $710M $619M $329M
Shares Outstanding 8-point trend, +5.6% 163,058,316 160,205,899 156,354,238 154,026,949 162,036,461 160,616,675 157,535,962 154,414,691 · · · ·
Cash Flow 18
Annual Cash Flow data for IRWD
Metric Trend 202520242023202220212020201920182017201620152014
D&A 12-point trend, -91.1% $1M $1M $1M $1M $2M $2M $6M $4M $6M $10M $12M $12M
Stock-based Comp 12-point trend, -34.1% $17M $30M $32M $27M $22M $31M $31M $41M $31M $29M $25M $26M
Deferred Tax 5-point trend, +112.2% $41M $68M $73M $66M $-333M · · · · · · ·
Amort. of Intangibles 3-point trend, +726.8% · · · · · · · $8M $6M $981.0K · ·
Restructuring 8-point trend, +3647.7% $21M $3M $17M · $1M $15M $4M $15M · · · $551.0K
Other Non-cash 8-point trend, -72.8% $44M $4M $1.08B $5M $43M $29M $-48M $161M · · · ·
Operating Cash Flow 12-point trend, +181.7% $127M $104M $183M $274M $262M $169M $11M $-71M $-101M $-26M $-107M $-156M
CapEx 12-point trend, -99.0% $34.0K $142.0K $273.0K $136.0K $265.0K $2M $7M $351.0K $3M $4M $4M $4M
Investing Cash Flow 12-point trend, +99.9% $-34.0K $-142.0K $-1.03B $-136.0K $-265.0K $-2M $-11M $89M $151M $-178M $-9M $-57M
Debt Issued · · · · · · · · $146M · · ·
Stock Issued · · · · · · · · · · · $190M
Stock Repurchased 2-point trend, +423.8% · · · $126M $24M · · · · · · ·
Net Stock Activity 3-point trend, -166.4% · · · $-126M $-24M · · · · · · $190M
Financing Cash Flow 12-point trend, -99.9% $216.0K $-107M $277M $-238M $-5M $19M $-1M $30M $20M $-4M $303M $211M
Net Change in Cash 11-point trend, -32.1% $127M $-4M $-566M $36M $257M $186M $-2M $48M $71M $-208M $187M ·
Taxes Paid 6-point trend, +91.7% $4M $8M $10M $5M $3M $2M · · · · · ·
Free Cash Flow 11-point trend, +179.8% $127M $103M $183M $274M $262M $167M $4M $-80M · $-30M $-111M $-159M
Levered FCF 4-point trend, +15.5% · · $160M $268M $180M $138M · · · · · ·
Profitability 7
Annual Profitability data for IRWD
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 11-point trend, +115.0% 33.3% 26.5% -213.5% 61.0% 56.1% 36.7% 28.0% -68.9% · -18.9% -68.3% -221.6%
Net Margin 8-point trend, +110.0% 8.1% 0.25% -226.4% 42.6% 127.7% 27.3% 5.0% -81.5% · · · ·
Pretax Margin 6-point trend, -15.4% 23.6% 18.6% -214.1% 61.5% 48.5% 28.0% · · · · · ·
EBITDA Margin 11-point trend, +116.4% 33.6% 26.8% -213.3% 61.3% 56.5% 37.3% 29.3% -67.2% · -15.2% -60.5% -205.4%
ROA 8-point trend, +110.7% 6.4% 0.21% -127.5% 15.7% 62.7% 22.1% 5.9% -60.2% · · · ·
ROE 8-point trend, -105.9% -8.5% -0.27% -654.9% 29.9% 94.6% 309.8% -17.5% 143.5% · · · ·
ROIC 6-point trend, -105.8% -12.9% -0.42% 297.1% 26.6% 101.0% 222.6% · · · · · ·
Liquidity & Solvency 4
Annual Liquidity & Solvency data for IRWD
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 11-point trend, -76.3% 1.1 4.7 0.8 30.6 4.6 15.4 7.5 2.2 · 4.2 6.5 4.8
Quick Ratio 11-point trend, -73.6% 1.1 4.4 0.8 30.2 4.5 15.1 4.6 1.6 · 3.4 5.8 4.1
Debt / Equity 3-point trend, -290.6% · · · · · · · -0.2 · · 0.3 0.1
Interest Coverage 9-point trend, -446.3% · · -43.7 32.9 7.5 4.8 3.3 -6.3 · -1.3 -3.3 -8.0
Efficiency 3
Annual Efficiency data for IRWD
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 11-point trend, +217.3% 0.8 0.9 0.6 0.4 0.5 0.8 1.2 0.7 · 0.4 0.3 0.2
Inventory Turnover 3-point trend, +1728.6% · · · · · · 34.5 · · 3.5 · 1.9
Receivables Turnover 11-point trend, -98.4% 4.6 3.3 3.6 3.6 3.5 5.8 26.6 28.7 · 143.5 103.4 292.3
Per Share 5
Annual Per Share data for IRWD
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 7-point trend, -171.3% $-1.61 $-1.88 $-2.21 $4.24 $3.74 $0.39 $-0.59 · · · · ·
Revenue / Share 6-point trend, -25.1% $1.82 $2.20 $2.85 $2.20 $2.52 $2.42 · · · · · ·
Cash Flow / Share 6-point trend, -25.8% $0.78 $0.65 $1.18 $1.47 $1.59 $1.05 · · · · · ·
Cash / Share 7-point trend, +17.6% $1.32 $0.55 $0.59 $4.26 $3.83 $2.26 $1.12 · · · · ·
EPS (TTM) 12-point trend, +106.3% $0.15 $0.01 $-6.45 $0.96 $3.21 $0.66 $0.14 $-1.85 $-2.38 $-2.38 $-2.38 $-2.38
Growth Rates 9
Annual Growth Rates data for IRWD
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, -352.7% -15.7% -20.6% 7.8% -0.76% 6.2% · · · · · · ·
Revenue CAGR 3Y 3-point trend, -336.7% -10.3% -5.3% 4.4% · · · · · · · · ·
Revenue CAGR 5Y -5.3% · · · · · · · · · · ·
EPS YoY 3-point trend, +262.4% 1400.0% · · -70.1% 386.4% · · · · · · ·
EPS CAGR 3Y 2-point trend, +46.0% -46.1% -85.4% · · · · · · · · · ·
EPS CAGR 5Y -25.7% · · · · · · · · · · ·
Net Income YoY 3-point trend, +561.1% 2629.2% · · -66.9% 397.7% · · · · · · ·
Net Income CAGR 3Y 2-point trend, +45.1% -48.4% -88.1% · · · · · · · · · ·
Net Income CAGR 5Y -25.7% · · · · · · · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for IRWD
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +287.4% $296M $351M $443M $411M $414M $390M $428M $347M $298M $274M $150M $76M
Net Income TTM 11-point trend, +116.8% $24M $880.0K $-1.00B $175M $528M $106M $22M $-282M $-117M $-82M $-143M ·
Market Cap 7-point trend, -73.8% $550M $710M $1.79B $1.91B $1.89B $1.83B $2.10B · · · · ·
P/E 12-point trend, +516.7% 22.5 443.0 -1.8 12.9 3.6 17.3 95.1 -4.7 -5.3 -5.4 -4.1 -5.4
P/S 7-point trend, -62.1% 1.9 2.0 4.0 4.6 4.6 4.7 4.9 · · · · ·
P/B 7-point trend, +90.7% -2.1 -2.4 -5.2 2.9 3.1 29.2 -22.5 · · · · ·
P / Tangible Book 3-point trend, -90.0% · · · 2.9 3.1 29.2 · · · · · ·
P / Cash Flow 7-point trend, -97.8% 4.3 6.9 9.8 7.0 7.2 10.8 195.5 · · · · ·
P / FCF 7-point trend, -99.3% 4.3 6.9 9.8 7.0 7.2 11.0 593.0 · · · · ·
Earnings Yield 12-point trend, +124.0% 4.5% 0.23% -56.4% 7.8% 27.5% 5.8% 1.1% -21.3% -19.0% -18.6% -24.5% -18.6%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $296M$351M$443M$411M$414M
Operating Margin % 33.3%26.5%-213.5%61.0%56.1%
Net Income $24M$880.0K$-1.00B$175M$528M
Diluted EPS $0.15$0.01$-6.45$0.96$3.21
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 1.14.70.830.64.6
Quick Ratio 1.14.40.830.24.5
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $127M$103M$183M$274M$262M

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Institutional owners (13F) 230 filers · $468.6M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
25 (-34 vs prior Q) 32 (+7 vs prior Q) 76 (-3 vs prior Q) 80 (+21 vs prior Q) -16.6M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
ARMISTICE CAPITAL, LLC $58,653,720 13,932,000 12.52% Shares
Sarissa Capital Management LP $38,684,153 9,188,635 8.26% Shares
STATE STREET CORP $37,088,420 8,809,601 7.92% Shares
RENAISSANCE TECHNOLOGIES LLC $33,651,481 7,993,226 7.18% Shares
VANGUARD CAPITAL MANAGEMENT LLC $27,821,819 6,608,508 5.94% Shares
BANK OF AMERICA CORP /DE/ $25,463,128 6,048,249 5.43% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $23,211,225 5,513,355 4.95% Shares
TWO SIGMA INVESTMENTS, LP $19,181,135 4,556,089 4.09% Shares
GEODE CAPITAL MANAGEMENT, LLC $18,001,965 4,275,108 3.84% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $17,117,708 4,065,964 3.65% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $13,902,439 3,302,242 2.97% Shares
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $12,701,945 3,017,089 2.71% Shares
TWO SIGMA ADVISERS, LP $10,582,137 3,140,100 2.26% Shares
DIMENSIONAL FUND ADVISORS LP $10,183,788 2,418,952 2.17% Shares
MACKENZIE FINANCIAL CORP $9,967,146 2,367,493 2.13% Shares
GOLDMAN SACHS GROUP INC $8,089,418 1,921,477 1.73% Shares
Connor, Clark & Lunn Investment Management Ltd. $7,622,630 1,810,601 1.63% Shares
Hillsdale Investment Management Inc. $5,264,302 1,250,428 1.12% Shares
VANGUARD FIDUCIARY TRUST CO $4,379,810 1,040,335 0.93% Shares
MARSHALL WACE, LLP $4,248,425 1,009,127 0.91% Shares
FMR LLC $3,818,234 906,944 0.81% Shares
STATE OF WISCONSIN INVESTMENT BOARD $3,277,548 778,515 0.70% Shares
BlackRock, Inc. $3,034,593 720,806 0.65% Shares
MORGAN STANLEY $2,899,132 688,630 0.62% Shares
VICTORY CAPITAL MANAGEMENT INC $2,772,104 658,457 0.59% Shares
IEQ CAPITAL, LLC $2,364,286 561,588 0.50% Shares
Vanguard Global Advisers, LLC $2,361,970 561,038 0.50% Shares
CITADEL ADVISORS LLC $2,115,117 502,403 0.45% Shares
PRUDENTIAL FINANCIAL INC $2,060,370 489,399 0.44% Shares
WEDGE CAPITAL MANAGEMENT L L P/NC $1,897,127 540,492 0.40% Shares
O'SHAUGHNESSY ASSET MANAGEMENT, LLC $1,847,815 438,911 0.39% Shares
Inspire Investing, LLC $1,789,893 509,941 0.38% Shares
SEGALL BRYANT & HAMILL, LLC $1,717,949 408,064 0.37% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,670,528 396,800 0.36% Put option
Man Group plc $1,650,813 392,117 0.35% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $1,641,029 389,793 0.35% Shares
BNP PARIBAS ASSET MANAGEMENT Holding S.A. $1,579,962 375,288 0.34% Shares
RITHOLTZ WEALTH MANAGEMENT $1,515,996 360,094 0.32% Shares
CM Management, LLC $1,473,500 350,000 0.31% Shares
Qube Research & Technologies Ltd $1,465,017 347,985 0.31% Shares
Robeco Institutional Asset Management B.V. $1,444,022 342,998 0.31% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $1,441,054 342,293 0.31% Shares
Virtus Investment Advisers, LLC $1,341,298 318,598 0.29% Shares
CWA Asset Management Group, LLC $1,222,441 290,366 0.26% Shares
GLOBEFLEX CAPITAL L P $1,093,796 259,809 0.23% Shares
VANGUARD GROUP INC $1,025,525 304,310 0.22% Shares
CWM, LLC $976,542 278,217 0.21% Shares
Bank of New York Mellon Corp $950,858 225,857 0.20% Shares
CITIGROUP INC $915,128 217,370 0.20% Shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC $913,316 219,445 0.19% Shares
RHUMBLINE ADVISERS $863,439 205,095 0.18% Shares
MARTINGALE ASSET MANAGEMENT L P $863,013 204,991 0.18% Shares
EVOLVE PRIVATE WEALTH, LLC $786,697 186,864 0.17% Shares
Vident Advisory, LLC $761,711 180,929 0.16% Shares
Cerity Partners LLC $734,490 174,463 0.16% Shares
KLP KAPITALFORVALTNING AS $733,382 174,200 0.16% Shares
Mariner, LLC $709,288 168,472 0.15% Shares
OMERS ADMINISTRATION Corp $669,432 159,010 0.14% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $666,443 158,300 0.14% Call option
Rafferty Asset Management, LLC $643,616 152,878 0.14% Shares
WELLINGTON MANAGEMENT GROUP LLP $640,299 152,090 0.14% Shares
Quantinno Capital Management LP $634,043 150,604 0.14% Shares
WELLS FARGO & COMPANY/MN $626,179 148,736 0.13% Shares
JPMORGAN CHASE & CO $622,047 144,662 0.13% Shares
ALLIANCEBERNSTEIN L.P. $581,923 165,790 0.12% Shares
FIFTH THIRD BANCORP $558,869 132,748 0.12% Shares
CANADA PENSION PLAN INVESTMENT BOARD $551,089 130,900 0.12% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $544,088 129,237 0.12% Shares
HSBC HOLDINGS PLC $541,600 126,100 0.12% Shares
Arax Advisory Partners $534,526 126,966 0.11% Shares
MERCER GLOBAL ADVISORS INC /ADV $531,134 126,160 0.11% Shares
JANE STREET GROUP, LLC $526,040 124,950 0.11% Shares
D. E. Shaw & Co., Inc. $517,438 122,907 0.11% Shares
Optimist Retirement Group LLC $429,647 102,054 0.09% Shares
State of Wyoming $428,498 101,781 0.09% Shares
Cercano Management LLC $426,801 101,378 0.09% Shares
AMERIPRISE FINANCIAL INC $419,004 99,526 0.09% Shares
CITADEL ADVISORS LLC $413,843 98,300 0.09% Put option
Engineers Gate Manager LP $412,799 98,052 0.09% Shares
MetLife Investment Management, LLC $405,036 96,208 0.09% Shares
Integrated Quantitative Investments LLC $394,431 93,689 0.08% Shares
FULLER & THALER ASSET MANAGEMENT, INC. $380,251 90,321 0.08% Shares
BARCLAYS PLC $369,584 87,787 0.08% Shares
WINTON GROUP Ltd $354,297 84,156 0.08% Shares
PROFUND ADVISORS LLC $327,344 77,754 0.07% Shares
CITADEL ADVISORS LLC $319,960 76,000 0.07% Call option
SmartHarvest Portfolios, LLC $317,695 75,462 0.07% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $317,569 75,432 0.07% Shares
Pallas Capital Advisors LLC $311,523 73,996 0.07% Shares
CAPTRUST FINANCIAL ADVISORS $301,883 71,706 0.06% Shares
Squarepoint Ops LLC $281,645 66,899 0.06% Shares
Invesco Ltd. $275,835 65,519 0.06% Shares
Vanguard Personalized Indexing Management, LLC $270,227 64,187 0.06% Shares
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO $252,284 59,925 0.05% Shares
AXQ CAPITAL, LP $197,988 47,028 0.04% Shares
Focus Partners Wealth $189,113 44,920 0.04% Shares
Police & Firemen's Retirement System of New Jersey $185,724 44,115 0.04% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $180,693 42,920 0.04% Shares
NEW YORK STATE COMMON RETIREMENT FUND $176,268 41,869 0.04% Shares
BRIGHTON JONES LLC $167,900 39,881 0.04% Shares

Company insiders 41 insiders · 18 officers · 22 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Thomas A Mccourt Chief Executive Officer March 10, 2026 A 1,898,838 0 2 $-739,929
Mark Mallon Chief Executive Officer Feb. 26, 2021 S 470,605 0 0 $0
Peter M. Hecht Chief Executive Officer April 1, 2019 D 2,217,366 0 0 $0
Gregory S. Martini Chief Financial Officer March 10, 2026 A 297,213 0 2 $-81,888
Sravan Kumar Emany SVP, COO and CFO Nov. 18, 2024 S 309,572 0 0 $0
Gina Consylman SVP, CFO & Treasurer March 26, 2021 A 392,616 0 0 $0
Jason Rickard SVP, Chief Operating Officer March 8, 2023 A 376,316 0 0 $0
William Huyett Chief Operating Officer April 1, 2019 D 27,546 0 0 $0
Michael J Higgins Chief Operating Officer Dec. 23, 2014 M 329,102 0 0 $0
Jeffrey Silber SVP, CMO, Head-Res&Drug July 20, 2026 A 137,036 0 0 $0
Ronald Silver PFO & PAO July 7, 2026 S 313,680 0 4 $-831,183
Tammi L Gaskins Chief Commercial Officer March 10, 2026 A 350,350 0 3 $-100,301
Minardo John Chief Legal Officer March 10, 2026 A 500,498 0 2 $-136,177
Michael Shetzline SVP, CMO, Head-Res&Drug March 10, 2026 A 658,037 0 2 $-121,586
Andrew Davis SVP, Chief Business Officer Nov. 18, 2024 S 284,685 0 0 $0
Conor Kilroy SVP, GC & Secretary Feb. 26, 2021 S 122,336 0 0 $0
Kelly Macdonald Chief Accounting Officer Dec. 4, 2020 M 93,041 0 0 $0
Halley E Gilbert Chief Admin Officer & SVP Feb. 21, 2020 S 265,991 0 0 $0
Catherine Moukheibir Director June 16, 2026 A 181,425 0 0 $0
Jon R Duane Director June 16, 2026 A 253,820 0 0 $0
Marla L Kessler Director June 16, 2026 A 229,364 0 0 $0
Jay Shepard Director June 16, 2026 A 235,036 0 0 $0
Julie Mchugh Director June 16, 2026 S 250,749 0 1 $-80,460
Mark G Currie Director June 16, 2026 A 676,900 0 0 $0
DENNER ALEXANDER J Director June 16, 2026 A 323,855 0 2 $-20,530,448
Andrew Dreyfus Director June 10, 2025 A 228,313 0 0 $0
Edward P Owens Director June 2, 2021 A 241,720 0 0 $0
Lawrence S Olanoff Director June 2, 2021 A 91,395 0 0 $0
Amy Schulman Director April 1, 2019 D 38,242 0 0 $0
Marsha Fanucci Director April 1, 2019 D 132,663 0 0 $0
Douglas E Williams Director April 1, 2019 D 87,800 0 0 $0
Terrance McGuire Director April 1, 2019 D 73,630 0 0 $0
WALSH CHRISTOPHER T PHD Director March 15, 2017 A 71,499 0 0 $0
George N Conrades Director June 3, 2015 A 62,221 0 0 $0
David A Ebersman Director March 13, 2015 A 29,714 0 0 $0
COOK JOSEPH C JR Director March 12, 2015 S 304,080 0 0 $0
David Evans Shaw Director March 14, 2014 A 64,306 0 0 $0
VR Management LLC 10% owner Jan. 15, 2013 J 2,442 0 0 $0
FMR LLC 10% owner July 10, 2012 S 2,340,891 0 0 $0
Thomas Graney Feb. 27, 2017 A 42,013 0 0 $0
Bryan E Roberts June 15, 2015 A 31,951 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 4 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Sarissa Capital Management LP, Alexander J. Denner March 19, 2026 5.80% Amendment SEC
Ironwood Pharmaceuticals, Inc. July 7, 2023 Initial filing M&A / sale SEC
OR ×3 filings March 1, 2021 Initial filing SEC
Nov. 9, 2020 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 42 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
BBC · ETFis Series Trust I 0.85% 77,097 NS April 30, 2026 N-PORT
QQQS · Invesco Exchange-Traded Fund Trust … 0.57% 31,360 SH Aug. 21, 2026 Daily
LABU · Direxion Shares ETF Trust 0.19% 233,156 NS April 30, 2026 N-PORT
IWC · iShares Trust 0.16% 565,156 SH Aug. 21, 2026 Daily
CALF · Pacer Funds Trust 0.13% 1,123,536 NS April 30, 2026 N-PORT
VFVA · VANGUARD WELLINGTON FUND 0.13% 267,285 SH Aug. 19, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.11% 521,040 SH Aug. 19, 2026 Daily
FNDA · SCHWAB STRATEGIC TRUST 0.10% 2,465,723 NS May 31, 2026 N-PORT
FSMD · FIDELITY COVINGTON TRUST 0.08% 450,064 NS April 30, 2026 N-PORT
IBB · iShares Trust 0.05% 1,174,921 SH Aug. 21, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.04% 9,682 SH Aug. 21, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.04% 165,563 SH Aug. 19, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.04% 273,163 SH Aug. 21, 2026 Daily
IWO · iShares Trust 0.04% 1,413,903 SH Aug. 21, 2026 Daily
JPSE · J.P. Morgan Exchange-Traded Fund Tr… 0.03% 43,650 NS April 30, 2026 N-PORT
BIB · ProShares Trust 0.03% 6,028 NS May 31, 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0.03% 73,969 NS May 31, 2026 N-PORT
IWM · iShares Trust 0.02% 4,196,923 SH Aug. 21, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.02% 943,404 SH Aug. 19, 2026 Daily
RSSL · Global X Funds 0.02% 69,316 NS April 30, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.02% 522,300 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.01% 7,530 NS May 31, 2026 N-PORT
RB · ProShares Trust 0.01% 46 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.01% 689,826 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.01% 1,677,357 SH Aug. 19, 2026 Daily
VHT · VANGUARD WORLD FUND 0.01% 437,643 SH Aug. 19, 2026 Daily
UWM · ProShares Trust 0.01% 5,889 NS May 31, 2026 N-PORT
FNDB · SCHWAB STRATEGIC TRUST 0.01% 26,377 NS May 31, 2026 N-PORT
URTY · ProShares Trust 0.01% 5,956 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 7,151 NS May 31, 2026 N-PORT
IWN · iShares Trust 0.00% 92,332 SH Aug. 21, 2026 Daily
HDG · ProShares Trust 0.00% 150 NS May 31, 2026 N-PORT
DCOR · Dimensional ETF Trust 0.00% 11,833 NS April 30, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.00% 100,870 NS April 30, 2026 N-PORT
ITOT · iShares Trust 0.00% 198,131 SH Aug. 21, 2026 Daily
IWV · iShares Trust 0.00% 41,115 SH Aug. 21, 2026 Daily
SCHB · SCHWAB STRATEGIC TRUST 0.00% 86,390 NS May 31, 2026 N-PORT
DFUS · Dimensional ETF Trust 0.00% 10,643 NS April 30, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.00% 4,781,484 SH Aug. 19, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.00% 9,494 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 13,354 SH Aug. 19, 2026 Daily
SMLF · iShares Trust 372,228 SH Aug. 21, 2026 Daily