Karen L. Smith

Insider

First SEC filing: May 28, 2020 · Latest: May 28, 2020

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Insider at Companies where this person is a reporting insider.
Insider transactions Every share this person bought or sold, from Form 4 filings.
Derivatives Options and other derivative holdings reported by this person.
Initial holdings The stakes this person held when they first started reporting.
Compensation Executive pay disclosed in company proxy statements.

Insider at

Insider transactions

0 buys (P) 0 sells (S) Net: $0 + 27 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

27 other filings hidden

Date	Ticker	Code	Shares	Price	Value	Owned after	Δ own	A/D	vs now
June 24, 2026	CNTX	A	45,000	—	—	45,000 Direct	—	Acquired	(price as of 2026-08-19)
Feb. 1, 2023	QNCX	A	225,000	—	—	225,000 Direct	—	Acquired	(price as of 2026-08-19)
May 23, 2022	QNCX	A	1,365,449	—	—	1,365,449 Direct	—	Acquired	(price as of 2026-08-19)
May 19, 2022	QNCX	A	170,354	—	—	194,690 Direct	+700.01%	Acquired	(price as of 2026-08-19)
May 19, 2022	QNCX	A	151,799	—	—	151,799 Direct	—	Acquired	(price as of 2026-08-19)
May 19, 2022	QNCX	A	24,336	—	—	24,336 Direct	—	Acquired	(price as of 2026-08-19)
May 7, 2021	EBS	F	305	$60.85	$18,559	11,888 Direct	-2.50%	Disposed	-92.1% (price as of 2026-08-19)
Feb. 24, 2021	EBS	A	2,942	—	—	9,252 Direct	+46.62%	Acquired	(price as of 2026-08-19)
Feb. 24, 2021	EBS	A	2,941	—	—	12,193 Direct	+31.79%	Acquired	(price as of 2026-08-19)
Feb. 24, 2021	EBS	A	11,765	$93.49	$1,099,910	11,765 Direct	—	Acquired	-94.8% (price as of 2026-08-19)
March 5, 2018	JAZZ	F	648	$143.39	$92,917	28,474 Direct	-2.23%	Disposed	77.8% (price as of 2026-08-19)
March 1, 2018	JAZZ	A	8,000	—	—	29,122 Direct	+37.88%	Acquired	(price as of 2026-08-19)
March 1, 2018	JAZZ	A	710	—	—	710 Direct	—	Acquired	(price as of 2026-08-19)
March 1, 2018	JAZZ	A	19,290	—	—	19,290 Direct	—	Acquired	(price as of 2026-08-19)
Feb. 26, 2018	JAZZ	F	525	$147.44	$77,406	21,122 Direct	-2.43%	Disposed	72.9% (price as of 2026-08-19)
March 2, 2017	JAZZ	A	7,500	—	—	21,168 Direct	+54.87%	Acquired	(price as of 2026-08-19)
March 2, 2017	JAZZ	A	902	—	—	902 Direct	—	Acquired	(price as of 2026-08-19)
March 2, 2017	JAZZ	A	17,848	—	—	17,848 Direct	—	Acquired	(price as of 2026-08-19)
Feb. 27, 2017	JAZZ	F	571	$136.97	$78,210	13,668 Direct	-4.01%	Disposed	86.1% (price as of 2026-08-19)
Aug. 12, 2016	JAZZ	P 10b5-1	607	$137.10	$83,220	14,181 Direct	+4.47%	Acquired	86.0% (price as of 2026-08-19)
Aug. 12, 2016	JAZZ	P 10b5-1	1	$137.26	$137	14,182 Direct	+0.01%	Acquired	85.7% (price as of 2026-08-19)
May 11, 2016	JAZZ	F	641	$148.76	$95,355	12,399 Direct	-4.92%	Disposed	71.4% (price as of 2026-08-19)
Feb. 25, 2016	JAZZ	A	6,000	—	—	13,143 Direct	+84.00%	Acquired	(price as of 2026-08-19)
Feb. 25, 2016	JAZZ	A	625	—	—	625 Direct	—	Acquired	(price as of 2026-08-19)
Feb. 25, 2016	JAZZ	A	14,375	—	—	14,375 Direct	—	Acquired	(price as of 2026-08-19)
May 11, 2015	JAZZ	A	6,830	—	—	6,830 Direct	—	Acquired	(price as of 2026-08-19)
May 11, 2015	JAZZ	A	275	—	—	7,105 Direct	+4.03%	Acquired	(price as of 2026-08-19)
May 11, 2015	JAZZ	A	2,264	—	—	2,264 Direct	—	Acquired	(price as of 2026-08-19)
May 11, 2015	JAZZ	A	15,516	—	—	15,516 Direct	—	Acquired	(price as of 2026-08-19)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II)

Options, RSUs and convertible securities reported on Form 4 Table II.

Date	Ticker	Security	Underlying	Exercise price	Expiration	Shares	A/D
June 24, 2026	CNTX	Stock Option (right to buy)	Common Stock (45,000)	$0.58	June 23, 2036	45,000	Acquired
Feb. 1, 2023	QNCX	Employee Stock Option (right to buy)	Common Stock (225,000)	$0.94	Jan. 31, 2033	225,000	Acquired
May 23, 2022	QNCX	Employee Stock Option (right to buy)	Common Stock (1,365,449)	$2.98	May 22, 2032	1,365,449	Acquired
May 19, 2022	QNCX	Employee Stock Option (right to buy)	Common Stock (151,799)	$0.55	March 27, 2032	151,799	Acquired
Feb. 24, 2021	EBS	Employee Stock Options (Right to Buy)	Common Stock (11,765)	$93.49	Feb. 23, 2028	11,765	Acquired
March 1, 2018	JAZZ	Incentive Stock Option (right to buy)	Ordinary Shares (710)	$140.67	Feb. 29, 2028	710	Acquired
March 1, 2018	JAZZ	Non-Qualified Stock Option (right to buy)	Ordinary Shares (19,290)	$140.67	Feb. 29, 2028	19,290	Acquired
March 2, 2017	JAZZ	Incentive Stock Option (right to buy)	Ordinary Shares (902)	$136.18	March 1, 2027	902	Acquired
March 2, 2017	JAZZ	Non-Qualified Stock Option (right to buy)	Ordinary Shares (17,848)	$136.18	March 1, 2027	17,848	Acquired
Feb. 25, 2016	JAZZ	Incentive Stock Option (right to buy)	Ordinary Shares (625)	$123.36	Feb. 24, 2026	625	Acquired
Feb. 25, 2016	JAZZ	Non-Qualified Stock Option (right to buy)	Ordinary Shares (14,375)	$123.36	Feb. 24, 2026	14,375	Acquired
May 11, 2015	JAZZ	Incentive Stock Option (right to buy)	Common Stock (2,264)	$176.51	May 10, 2025	2,264	Acquired
May 11, 2015	JAZZ	Non-Qualified Stock Option (right to buy)	Ordinary Shares (15,516)	$176.51	May 10, 2025	15,516	Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 2 holdings

Securities held when first becoming an insider, per SEC Form 3.

Date	Ticker	Security	Shares	Ownership
May 28, 2020	EBS	Common Stock	6,310	Direct
May 28, 2020	EBS	Employee Stock Options (Right to Buy)→ Common Stock (12,619)	12,619	Direct

Compensation (DEF 14A)

Matched by name from proxy statements (DEF 14A) — verify against the filing.

JAZZ

Fiscal year	Salary	Bonus	Stock awards	Option awards	Non-equity incentive	Pension change	Other	Total
2017	$516,923	—	$1,176,530	$915,873	$287,700	—	$10,722	$2,907,748
2016	$496,154	—	—	—	$245,000	—	$4,695	$2,087,805
2015	$337,981	$290,000	—	—	$130,000	—	$67,492	$3,113,926

QNCX

Fiscal year	Salary	Bonus	Stock awards	Option awards	Non-equity incentive	Pension change	Other	Total
2023	$336,458	—	$66,256	—	—	—	$696,168	$1,347,920
2022	$273,734	—	—	—	$115,208	—	$4,000	$3,485,274

Figures from the Summary Compensation Table of the company's proxy statement (DEF 14A). Compensation is not a recommendation.