SKYE Skye Bioscience, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$0.34
Price · Aug 19, 2026
Fundamentals as of Aug 14, 2026

SKYE Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$0.34
Market Cap
$11M
P/E (TTM)
-0.2
EPS (TTM)
$-1.41
Revenue (TTM)
Div Yield
ROE
-175.6%
Debt/Equity
52W Range
$0 – $5

SKYE Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income
EPS $-1.41
8-point trend, -781.2%
2018-12-31 2025-12-31
Free Cash Flow $-43M
6-point trend, -610.5%
2020-12-31 2025-12-31
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
SKYE
Peer Median
P/E (TTM)
5-point trend, +99.9%
-0.2
P/B
5-point trend, -99.9%
0.6
1.8
Price / FCF
5-point trend, +99.9%
-0.3

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
SKYE
Peer Median
ROA
5-point trend, +18.7%
-110.7%
-72.2%
ROE
5-point trend, -45.6%
-175.6%
-94.1%
ROIC
5-point trend, -117.0%
-290.5%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
SKYE
Peer Median
Current Ratio
5-point trend, +34.4%
3.3
4.0
Quick Ratio
5-point trend, +36.6%
3.1

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
SKYE
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
SKYE
Peer Median
EPS (Diluted)
5-point trend, -6950.0%
$-1.41

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
SKYE
Peer Median

SKYE Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 13 analysts
  • Strong Buy 3 23.1%
  • Buy 7 53.8%
  • Hold 3 23.1%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

5 analysts · 2026-08-19
Median target $4.00 +1076.1%
Mean target $7.60 +2134.6%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.48%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.32 $-0.32 -0.00%
Dec. 31, 2025 $-0.36 $-0.30 -0.06%
Sept. 30, 2025 $-0.32 $-0.34 0.02%
June 30, 2025 $-2.69 $-0.32 -2.4%
March 31, 2025 $-0.28 $-0.29 0.01%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
SKYE $25M -0.5 -175.6%
CELU $32M -0.3 -51.0% -345.4% 288.6%
CLRB -0.4
HOWL $31M -0.5 -183.6%
MRKR $25M -1.9 -46.2% -343.0% -89.1%
KALA $15M -0.2 -1423.8%
CYCN -1.1 3.7%
TPST $14M -0.5 -319.3%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 15
Annual Income Statement data for SKYE
Metric Trend 20252024202320222021202020192018
R&D Expense 5-point trend, +1721.9% · · · $6M $3M $2M $2M $330.0K
SG&A Expense 8-point trend, +262.2% $16M $18M $8M $6M $5M $4M $4M $4M
Operating Expenses 8-point trend, +1139.5% $58M $30M $35M $18M $8M $6M $7M $5M
Operating Income 8-point trend, -1139.5% $-58M $-30M $-35M $-18M $-8M $-6M $-7M $-5M
Interest Expense 8-point trend, -100.0% $0 $749.3K $906.3K $665.1K $769.2K $706.4K $1M $94.8K
Interest Income 8-point trend, +2242641.7% $2M $3M $100.0K $19.0K $3 $29 $26 $84
Other Non-op 8-point trend, +100.0% $-502 $-2.2K $3 $-1M $-672.4K $-270.1K $8M $-15M
Pretax Income 8-point trend, -191.4% $-56M $-27M $-38M $-19M $-9M $-7M $1M $-19M
Income Tax 8-point trend, +228.9% $5.4K $10.1K $3.6K $6.7K $2.1K $1.6K $1.6K $1.6K
Net Income 8-point trend, -191.4% $-56M $-27M $-38M $-19M $-9M $-7M $1M $-19M
EPS (Basic) 8-point trend, -781.2% $-1.41 $-0.73 $-5.37 $-8.77 $-0.02 $-0.03 $0.01 $-0.16
EPS (Diluted) 8-point trend, -781.2% $-1.41 $-0.73 $-5.37 $-8.77 $-0.02 $-0.03 $-0.05 $-0.16
Shares (Basic) 8-point trend, -67.3% 39,662,664 36,486,519 7,006,038 2,221,080 406,599,390 230,746,878 135,154,931 121,154,334
Shares (Diluted) 8-point trend, -67.3% 39,662,664 36,486,519 7,006,038 2,221,080 406,599,390 231,420,973 169,560,265 121,154,334
EBITDA 7-point trend, -766.0% $-57M $-30M $-35M $-18M $-8M $-6M $-7M ·
Balance Sheet 20
Annual Balance Sheet data for SKYE
Metric Trend 20252024202320222021202020192018
Cash & Equivalents 8-point trend, +217.4% $6M $68M $1M $1M $9M $2M $2M $2M
Short-term Investments 2-point trend, +19854723.00 $20M $0 · · · · · ·
Prepaid Expense 8-point trend, +441.8% $504.9K $202.0K $194.3K $780.8K $554.2K $190.1K $152.7K $93.2K
Other Current Assets 8-point trend, +32557.6% $852.0K $2M $1M $481.6K $56.9K $275 $7.5K $2.6K
Current Assets 8-point trend, +1286.8% $27M $71M $12M $9M $10M $3M $2M $2M
PP&E (Net) 8-point trend, +25993.8% $898.9K $1M $43.3K $87.9K $87.7K $7.3K $2.0K $3.4K
PP&E (Gross) 3-point trend, +1105.8% $2M $2M $138.7K · · · · ·
Accum. Depreciation 3-point trend, +710.7% $773.6K $233.5K $95.4K · · · · ·
Other Non-current Assets 6-point trend, +53910.00 $53.9K $53.9K $8.3K $8.3K $8.3K $0 · ·
Total Assets 8-point trend, +1346.7% $28M $73M $12M $9M $10M $3M $2M $2M
Accounts Payable 8-point trend, +12937.3% $2M $569.3K $1M $2M $897.9K $364.3K $129.8K $15.6K
Accrued Liabilities 2-point trend, -93.0% · · · · · $5.5K $77.9K ·
Current Liabilities 8-point trend, -48.5% $8M $4M $14M $12M $4M $787.2K $970.8K $16M
Capital Leases 6-point trend, +83999.00 $84.0K $273.2K $171.2K $0 $78.7K $0 · ·
Total Liabilities 8-point trend, -52.7% $8M $5M $14M $12M $4M $2M $1M $18M
Common Stock 8-point trend, -75.1% $33.4K $31.0K $12.3K $3.7K $476.1K $288.1K $182.9K $133.9K
Retained Earnings 8-point trend, -462.4% $-187M $-131M $-104M $-67M $-47M $-39M $-32M $-33M
Stockholders' Equity 8-point trend, +228.7% $20M $68M $-2M $-3M $6M $450.8K $548.1K $-16M
Liabilities + Equity 8-point trend, +1346.7% $28M $73M $12M $9M $10M $3M $2M $2M
Shares Outstanding 8-point trend, -75.1% 33,378,139 30,974,559 12,349,243 3,654,119 476,108,445 288,074,415 182,895,247 133,907,747
Cash Flow 12
Annual Cash Flow data for SKYE
Metric Trend 20252024202320222021202020192018
D&A 3-point trend, +482.2% $723.4K $298.6K $124.3K · · · · ·
Stock-based Comp 8-point trend, +1050.8% $8M $8M $987.5K $629.0K $869.2K $302.7K $680.5K $675.0K
Other Non-cash 2-point trend, +160.0% $4M $-7M · · · · · ·
Operating Cash Flow 8-point trend, -992.1% $-43M $-25M $-14M $-13M $-6M $-6M $-6M $-4M
CapEx 7-point trend, +43.9% $6.3K $2M $12.6K $28.1K $90.9K $7.2K · $4.4K
Investing Cash Flow 7-point trend, -444604.3% $-20M $-245.6K $7M $5M $-90.9K $-7.2K · $-4.4K
Stock Issued 7-point trend, -100.0% · $0 $5M $0 $6M $6M $2M $3M
Net Stock Activity 6-point trend, -100.0% · $0 $5M $0 $6M $6M $2M ·
Financing Cash Flow 8-point trend, -99.5% $29.6K $84M $16M $-208.8K $13M $7M $6M $6M
Net Change in Cash 8-point trend, -4024.3% $-63M $58M $9M $-8M $7M $639.5K $-23.4K $2M
Free Cash Flow 6-point trend, -610.5% $-43M $-27M $-14M $-13M $-7M $-6M · ·
Levered FCF 6-point trend, -536.4% $-43M $-28M $-15M $-13M $-7M $-7M · ·
Profitability 3
Annual Profitability data for SKYE
Metric Trend 20252024202320222021202020192018
ROA 7-point trend, -308.0% -110.7% -62.7% -357.6% -205.4% -136.1% -281.1% 53.2% ·
ROE 7-point trend, -1223.2% -175.6% -36.9% 17246.1% 619.1% -120.6% -569.5% -13.3% ·
ROIC 7-point trend, +76.0% -290.5% -44.3% 1629.5% 609.0% -133.9% -1395.5% -1208.4% ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for SKYE
Metric Trend 20252024202320222021202020192018
Current Ratio 7-point trend, +60.7% 3.3 16.3 0.8 0.7 2.5 3.4 2.1 ·
Quick Ratio 7-point trend, +66.4% 3.1 15.8 0.1 0.1 2.3 3.1 1.9 ·
Interest Coverage 6-point trend, -507.9% · -40.3 -38.3 -27.5 -10.2 -8.9 -6.6 ·
Per Share 4
Annual Per Share data for SKYE
Metric Trend 20252024202320222021202020192018
Book Value / Share 7-point trend, +19896.7% $0.60 $2.20 $-0.17 $-0.00 $0.01 $0.00 $0.00 ·
Cash Flow / Share 7-point trend, -2949.7% $-1.09 $-0.69 $-1.99 $-0.02 $-0.02 $-0.03 $-0.04 ·
Cash / Share 7-point trend, +1662.0% $0.18 $2.21 $0.10 $0.00 $0.02 $0.01 $0.01 ·
EPS (TTM) 8-point trend, -781.2% $-1.41 $-0.73 $-5.37 $-8.77 $-0.02 $-0.03 $-0.05 $-0.16
Valuation (TTM) 8
Annual Valuation (TTM) data for SKYE
Metric Trend 20252024202320222021202020192018
Net Income TTM 8-point trend, -191.4% $-56M $-27M $-38M $-19M $-9M $-7M $1M $-19M
Market Cap 7-point trend, -99.6% $25M $88M $34M $3.65B $6.19B $2.88B $5.99B ·
P/E 8-point trend, +99.9% -0.5 -3.9 -0.5 -0.5 -650.0 -333.3 -655.0 -625.0
P/B 7-point trend, -100.0% 1.3 1.3 -15.8 -1214.8 1055.5 6390.5 10929.2 ·
P / Tangible Book 4-point trend, -100.0% 1.3 1.3 · · 1055.5 6390.5 · ·
P / Cash Flow 7-point trend, +99.9% -0.6 -3.5 -2.4 -286.7 -955.9 -475.8 -993.7 ·
P / FCF 6-point trend, +99.9% -0.6 -3.3 -2.4 -286.1 -942.7 -475.3 · ·
Earnings Yield 8-point trend, -117400.0% -188.0% -25.8% -197.4% -219.2% -0.15% -0.30% -0.15% -0.16%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Net Income $-56M$-27M$-38M$-19M$-9M
Diluted EPS $-1.41$-0.73$-5.37$-8.77$-0.02
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 3.316.30.80.72.5
Quick Ratio 3.115.80.10.12.3
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-43M$-27M$-14M$-13M$-7M

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Institutional owners (13F) 50 filers · $11.3M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
11 (+9 vs prior Q) 3 (-10 vs prior Q) 4 (-5 vs prior Q) 9 (0 vs prior Q) +1.1M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
5AM Venture Management, LLC $6,712,366 9,681,763 59.24% Shares
Versant Venture Management, LLC $1,391,941 2,007,704 12.28% Shares
BAKER BROS. ADVISORS LP $1,092,116 1,575,243 9.64% Shares
VANGUARD CAPITAL MANAGEMENT LLC $529,370 763,882 4.67% Shares
SPHERA FUNDS MANAGEMENT LTD. $470,701 678,928 4.15% Shares
PLATINUM INVESTMENT MANAGEMENT LTD $161,605 233,095 1.43% Shares
BlackRock, Inc. $161,449 232,870 1.42% Shares
MILLENNIUM MANAGEMENT LLC $137,637 198,524 1.21% Shares
GEODE CAPITAL MANAGEMENT, LLC $124,295 179,201 1.10% Shares
VANGUARD GROUP INC $78,172 104,229 0.69% Shares
VANGUARD FIDUCIARY TRUST CO $72,231 104,229 0.64% Shares
Nuveen Asset Management, LLC $66,191 23,389 0.58% Shares
CITADEL ADVISORS LLC $61,426 88,600 0.54% Call option
STATE STREET CORP $51,186 73,830 0.45% Shares
NORTHERN TRUST CORP $39,052 56,327 0.34% Shares
UBS Group AG $37,744 54,465 0.33% Shares
TWO SIGMA ADVISERS, LP $30,724 40,982 0.27% Shares
Qube Research & Technologies Ltd $29,869 43,082 0.26% Shares
CITADEL ADVISORS LLC $24,543 35,400 0.22% Put option
SIMPLEX TRADING, LLC $18,702 26,976 0.17% Shares
XTX Topco Ltd $14,554 20,993 0.13% Shares
Engineers Gate Manager LP $14,001 20,194 0.12% Shares
GROUP ONE TRADING LLC $3,182 4,589 0.03% Shares
Vanguard Global Advisers, LLC $3,158 4,557 0.03% Shares
MERCER GLOBAL ADVISORS INC /ADV $2,125 3,065 0.02% Shares
MORGAN STANLEY $1,352 1,950 0.01% Shares
BARCLAYS PLC $455 655 0.00% Shares
OSAIC HOLDINGS, INC. $413 600 0.00% Shares
NATIONAL BANK OF CANADA /FI/ $275 400 0.00% Shares
JPMORGAN CHASE & CO $44 66 0.00% Shares
Zurcher Kantonalbank (Zurich Cantonalbank) $36 52 0.00% Shares
TD Waterhouse Canada Inc. $35 52 0.00% Shares
Federation des caisses Desjardins du Quebec $35 51 0.00% Shares
Rockefeller Capital Management L.P. $27 39 0.00% Shares
Optiver Holding B.V. $14 20 0.00% Shares
CoreCap Advisors, LLC $6 8 0.00% Shares
JONES FINANCIAL COMPANIES LLLP $5 8 0.00% Shares
GILPIN WEALTH MANAGEMENT, LLC $3 4 0.00% Shares
Integrated Wealth Concepts LLC $2 2 0.00% Shares
Plante Moran Financial Advisors, LLC $2 3 0.00% Shares
PFS Partners, LLC $1 1 0.00% Shares
HARBOUR INVESTMENTS, INC. $1 1 0.00% Shares
Leo H. Evart, Inc. $1 1 0.00% Shares
TUCKER ASSET MANAGEMENT LLC $1 1 0.00% Shares
WELLS FARGO & COMPANY/MN $1 1 0.00% Shares
NFSG Corp $1 1 0.00% Shares
MCGUIRE CAPITAL ADVISORS INC $1 2 0.00% Shares
FMR LLC $1 1 0.00% Shares
IFP Advisors, Inc $1 1 0.00% Shares
ROYAL BANK OF CANADA $0 120 0.00% Shares

Company insiders 15 insiders · 6 officers · 10 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Brian Stuart Murphy CEO, Chief Medical Officer Oct. 20, 2015 A 375,000 0 0 $0
John B Hollister Chief Executive Officer Dec. 4, 2014 A 0 0 $0
Douglas A Cesario CFO and Secretary July 23, 2018 A 643,501 0 0 $0
Elizabeth Berecz Chief Financial Officer Oct. 20, 2015 A 350,000 0 0 $0
Cosmas N Lykos Chairman Oct. 20, 2015 A 3,699,400 0 0 $0
Douglas S Ingram Vice Chairman Oct. 20, 2015 A 372,500 0 0 $0
Andrew J. Schwab Director Jan. 31, 2024 A 7,943,520 0 0 $0
Praveen Tyle Director July 22, 2021 A 0 0 $0
James L Heppell Director Oct. 10, 2018 A 0 0 $0
Avtar S Dhillon Director Oct. 10, 2018 A 0 0 $0
Gerald W. Mclaughlin Director Oct. 20, 2015 A 61,250 0 0 $0
Thomas George Director Oct. 20, 2015 A 60,000 0 0 $0
Emerald Health Sciences Inc. 10% owner Feb. 1, 2019 J 73,153,917 0 0 $0
Reg Alexander Lapham 10% owner March 13, 2017 X 3,787,500 0 0 $0
Punit Dhillon Aug. 7, 2026 A 1,419,823 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 8 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
5AM Co-Investors II, L.P., 5AM Partners II, LLC, 5AM Partners VII, LLC, 5AM Ventures II, L.P., 5AM Ventures VII, L.P., Andrew J. Schwab, John D. Diekman, Kush Parmar, Scott M. Rocklage Aug. 18, 2026 30.20% Amendment SEC
5AM Partners VII, LLC, 5AM Ventures VII, L.P., 5AM Partners II, LLC, 5AM Ventures II, L.P., 5AM Co-Investors II, L.P., Andrew J. Schwab, Kush Parmar, John D. Diekman, Scott M. Rocklage ×2 filings Dec. 16, 2025 34.00% Amendment SEC
5AM Ventures VII, L.P., 5AM Partners VII, LLC, 5AM Ventures II, L.P., 5AM Co-Investors II, L.P., 5AM Partners II, LLC, Andrew J. Schwab, Kush Parmar, John D. Diekman, Scott M. Rocklage ×3 filings March 13, 2024 Initial filing SEC
Emerald Health Sciences Inc. ×9 filings March 20, 2023 Initial filing SEC
Undisclosed reporting person March 28, 2017 Initial filing SEC
Cosmas N. Lykos ×2 filings Feb. 1, 2016 Initial filing SEC
YOSBANI MENDEZ ×2 filings Nov. 12, 2014 Initial filing Passive investment SEC
Reg Alexander Lapham Nov. 10, 2014 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 2 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
VXF · VANGUARD INDEX FUNDS 0.00% 184,978 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 561,832 SH Aug. 8, 2026 Daily