Insider at

04

Insider transactions

05
0 buys (P) 38 sells (S) Net: $-36,341,854 + 36 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

36 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
July 8, 2026 APGE S 10b5-1 20,000 $133.63 $2,672,600 995,987 Direct -1.97% Disposed
June 22, 2026 APGE S 10b5-1 80,000 $132.54 $10,603,200 1,015,987 Direct -7.30% Disposed
June 22, 2026 SYRE S 10b5-1 20,000 $100.00 $2,000,000 68,606 Direct -22.57% Disposed -6.8% (price as of 2026-10-02)
June 10, 2026 APGE S 10b5-1 614 $86.89 $53,350 1,095,987 Direct -0.06% Disposed
June 10, 2026 APGE S 10b5-1 2,305 $86.27 $198,852 1,096,601 Direct -0.21% Disposed
June 10, 2026 APGE S 10b5-1 1,577 $85.19 $134,345 1,098,906 Direct -0.14% Disposed
June 10, 2026 APGE S 10b5-1 1,080 $84.18 $90,914 1,100,483 Direct -0.10% Disposed
June 10, 2026 APGE S 10b5-1 7,654 $82.78 $633,598 1,101,563 Direct -0.69% Disposed
June 10, 2026 APGE S 10b5-1 6,770 $82.21 $556,562 1,109,217 Direct -0.61% Disposed
May 13, 2026 APGE S 10b5-1 1,341 $82.58 $110,740 1,115,987 Direct -0.12% Disposed
May 13, 2026 APGE S 10b5-1 18,659 $82.05 $1,530,971 1,117,328 Direct -1.64% Disposed
May 8, 2026 SYRE S 10b5-1 2,404 $72.57 $174,458 166,202 Direct -1.43% Disposed 28.4% (price as of 2026-10-02)
May 8, 2026 SYRE S 10b5-1 33,513 $73.72 $2,470,578 132,689 Direct -20.16% Disposed 26.4% (price as of 2026-10-02)
May 8, 2026 SYRE S 10b5-1 24,814 $74.76 $1,855,095 107,875 Direct -18.70% Disposed 24.7% (price as of 2026-10-02)
May 8, 2026 SYRE S 10b5-1 19,269 $75.35 $1,451,919 88,606 Direct -17.86% Disposed 23.7% (price as of 2026-10-02)
April 8, 2026 APGE S 10b5-1 17,800 $82.48 $1,468,144 1,135,187 Direct -1.54% Disposed
April 8, 2026 APGE S 10b5-1 2,000 $83.26 $166,520 1,133,187 Direct -0.18% Disposed
April 8, 2026 APGE S 10b5-1 200 $85.00 $17,000 1,132,987 Direct -0.02% Disposed
March 11, 2026 APGE S 10b5-1 8,363 $74.29 $621,287 1,164,624 Direct -0.71% Disposed
March 11, 2026 APGE S 10b5-1 8,219 $74.83 $615,028 1,156,405 Direct -0.71% Disposed
March 11, 2026 APGE S 10b5-1 3,418 $75.86 $259,289 1,152,987 Direct -0.30% Disposed
Feb. 11, 2026 APGE S 10b5-1 955 $64.99 $62,065 1,172,987 Direct -0.08% Disposed
Feb. 11, 2026 APGE S 10b5-1 7,551 $63.73 $481,225 1,173,942 Direct -0.64% Disposed
Feb. 11, 2026 APGE S 10b5-1 11,494 $62.96 $723,662 1,181,493 Direct -0.96% Disposed
Jan. 14, 2026 APGE S 10b5-1 470 $83.79 $39,381 1,192,987 Direct -0.04% Disposed
Jan. 14, 2026 APGE S 10b5-1 5,386 $83.16 $447,900 1,193,457 Direct -0.45% Disposed
Jan. 14, 2026 APGE S 10b5-1 1,854 $82.41 $152,788 1,198,843 Direct -0.15% Disposed
Jan. 14, 2026 APGE S 10b5-1 2,374 $81.00 $192,294 1,200,697 Direct -0.20% Disposed
Jan. 14, 2026 APGE S 10b5-1 8,476 $79.82 $676,554 1,203,071 Direct -0.70% Disposed
Jan. 14, 2026 APGE S 10b5-1 1,440 $78.64 $113,242 1,211,547 Direct -0.12% Disposed
Dec. 10, 2025 APGE S 10b5-1 560 $76.58 $42,885 1,212,987 Direct -0.05% Disposed
Dec. 10, 2025 APGE S 10b5-1 10,005 $75.79 $758,279 1,213,547 Direct -0.82% Disposed
Dec. 10, 2025 APGE S 10b5-1 9,435 $74.88 $706,493 1,223,552 Direct -0.77% Disposed
Dec. 4, 2025 APGE S 10b5-1 40,000 $75.01 $3,000,400 1,232,987 Direct -3.14% Disposed
Nov. 13, 2025 APGE S 10b5-1 100 $64.52 $6,452 1,272,987 Direct -0.01% Disposed
Nov. 13, 2025 APGE S 10b5-1 1,786 $63.89 $114,108 1,273,087 Direct -0.14% Disposed
Nov. 13, 2025 APGE S 10b5-1 14,774 $63.14 $932,830 1,274,873 Direct -1.15% Disposed
Nov. 13, 2025 APGE S 10b5-1 3,340 $61.93 $206,846 1,289,647 Direct -0.26% Disposed
March 5, 2025 APGE S 10b5-1 2,674 $30.62 $81,878 1,292,987 Direct -0.21% Disposed
March 5, 2025 APGE S 10b5-1 7,326 $29.98 $219,633 1,295,661 Direct -0.56% Disposed
Feb. 5, 2025 APGE S 10b5-1 15,000 $40.58 $608,700 1,302,987 Direct -1.14% Disposed
Jan. 8, 2025 APGE S 10b5-1 2,868 $49.38 $141,622 1,309,487 Direct -0.22% Disposed
Jan. 8, 2025 APGE S 10b5-1 12,132 $48.72 $591,071 1,312,355 Direct -0.92% Disposed
Dec. 4, 2024 APGE S 10b5-1 1,672 $47.19 $78,902 1,324,487 Direct -0.13% Disposed
Dec. 4, 2024 APGE S 10b5-1 13,328 $46.50 $619,752 1,326,159 Direct -1.00% Disposed
Nov. 6, 2024 APGE S 10b5-1 1,000 $59.94 $59,940 1,339,487 Direct -0.07% Disposed
Nov. 6, 2024 APGE S 10b5-1 14,000 $59.17 $828,380 1,340,487 Direct -1.03% Disposed
Oct. 2, 2024 APGE S 10b5-1 9,712 $56.74 $551,059 1,354,487 Direct -0.71% Disposed
Oct. 2, 2024 APGE S 10b5-1 30,288 $56.07 $1,698,248 1,364,199 Direct -2.17% Disposed
Sept. 4, 2024 APGE S 10b5-1 14,359 $48.23 $692,535 1,394,487 Direct -1.02% Disposed
Sept. 4, 2024 APGE S 10b5-1 25,641 $47.28 $1,212,306 1,408,846 Direct -1.79% Disposed
Aug. 7, 2024 APGE S 10b5-1 100 $42.17 $4,217 1,434,487 Direct -0.01% Disposed
Aug. 7, 2024 APGE S 10b5-1 7,667 $41.52 $318,334 1,434,587 Direct -0.53% Disposed
Aug. 7, 2024 APGE S 10b5-1 32,233 $40.40 $1,302,213 1,442,254 Direct -2.19% Disposed
July 5, 2024 APGE S 10b5-1 15,000 $37.26 $558,900 1,474,487 Direct -1.01% Disposed
Dec. 1, 2020 BBIO S 10b5-1 6,972 $51.69 $360,383 274,211 Direct -2.48% Disposed 30.1% (price as of 2026-10-02)
Dec. 1, 2020 BBIO S 10b5-1 3,028 $51.12 $154,791 281,183 Direct -1.07% Disposed 31.6% (price as of 2026-10-02)
Nov. 16, 2020 BBIO S 10b5-1 10,000 $45.00 $450,000 267,751 Direct -3.60% Disposed 49.4% (price as of 2026-10-02)
Nov. 2, 2020 BBIO S 10b5-1 500 $38.92 $19,460 267,751 Direct -0.19% Disposed 72.8% (price as of 2026-10-02)
Nov. 2, 2020 BBIO S 10b5-1 9,500 $38.33 $364,135 268,251 Direct -3.42% Disposed 75.5% (price as of 2026-10-02)
Oct. 1, 2020 BBIO S 10b5-1 5,505 $39.28 $216,236 267,751 Direct -2.01% Disposed 71.2% (price as of 2026-10-02)
Oct. 1, 2020 BBIO S 10b5-1 4,495 $38.29 $172,114 273,256 Direct -1.62% Disposed 75.6% (price as of 2026-10-02)
Sept. 18, 2020 BBIO S 10b5-1 10,000 $40.00 $400,000 267,751 Direct -3.60% Disposed 68.1% (price as of 2026-10-02)
June 3, 2020 BBIO S 10b5-1 784 $30.04 $23,551 261,399 Direct -0.30% Disposed 123.9% (price as of 2026-10-02)

Showing latest 100 of 159 transactions

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
Sept. 3, 2026 APGE Stock Option (Right to Buy) Common Stock (387,012) $22.86 Dec. 18, 2033 387,012 Disposed
Sept. 3, 2026 APGE Stock Option (Right to Buy) Common Stock (357,036) $49.07 Dec. 9, 2034 357,036 Disposed
Sept. 3, 2026 APGE Stock Option (Right to Buy) Common Stock (253,016) $75.78 Jan. 2, 2036 253,016 Disposed
May 27, 2026 SYRE Stock Option (Right to Buy) Common Stock (8,026) $72.51 May 27, 2036 8,026 Acquired
April 16, 2026 APGE Stock Option (Right to Buy) Common Stock (3,000) $22.86 Dec. 18, 2033 3,000 Disposed
Jan. 2, 2026 APGE Stock Option (Right to Buy) Common Stock (253,016) $75.78 Jan. 2, 2036 253,016 Acquired
May 29, 2025 SYRE Stock Option (Right to Buy) Common Stock (25,000) $15.55 May 29, 2035 25,000 Acquired
Jan. 31, 2025 APGE Stock Option (Right to Buy) Common Stock (8,500) $22.86 Dec. 18, 2033 8,500 Disposed
Dec. 9, 2024 APGE Stock Option (Right to Buy) Common Stock (357,036) $49.07 Dec. 9, 2034 357,036 Acquired
May 14, 2024 SYRE Stock Option (Right to Buy) Common Stock (11,323) $39.29 May 14, 2034 11,323 Acquired
Dec. 18, 2023 APGE Stock Option (Right to Buy) Common Stock (398,512) $22.86 Dec. 18, 2033 398,512 Acquired
Dec. 15, 2020 BBIO Stock Option (Right to Buy) Common Stock (2,199) $42.80 Sept. 29, 2030 2,199 Acquired
Dec. 15, 2020 BBIO Stock Option (Right to Buy) Common Stock (3,137) $3.07 July 20, 2030 3,137 Acquired
Dec. 15, 2020 BBIO Stock Option (Right to Buy) Common Stock (4,456) $3.07 April 1, 2030 4,456 Acquired
Dec. 1, 2020 BBIO Stock Option (Right to Buy) Common Stock (10,000) $1.05 Sept. 24, 2029 10,000 Disposed
Nov. 16, 2020 BBIO Restricted Stock Units Common Stock (12,813) · · 12,813 Disposed
Nov. 16, 2020 BBIO Stock Option (Right to Buy) Common Stock (10,000) $1.05 Sept. 24, 2029 10,000 Disposed
Nov. 2, 2020 BBIO Stock Option (Right to Buy) Common Stock (10,000) $1.05 Sept. 24, 2029 10,000 Disposed
Oct. 1, 2020 BBIO Stock Option (Right to Buy) Common Stock (6,745) $1.05 Sept. 24, 2029 6,745 Disposed
Oct. 1, 2020 BBIO Stock Option (Right to Buy) Common Stock (1,019) $0.28 May 7, 2028 1,019 Disposed
Oct. 1, 2020 BBIO Stock Option (Right to Buy) Common Stock (2,236) $0.28 Nov. 13, 2027 2,236 Disposed
Sept. 18, 2020 BBIO Stock Option (Right to Buy) Common Stock (5,099) $0.28 Nov. 13, 2027 5,099 Disposed
Sept. 18, 2020 BBIO Stock Option (Right to Buy) Common Stock (4,901) $0.16 Aug. 26, 2028 4,901 Disposed
Sept. 1, 2020 BBIO Stock Option (Right to Buy) Common Stock (10,000) $0.16 Aug. 26, 2028 10,000 Disposed
Aug. 16, 2020 BBIO Restricted Stock Units Common Stock (12,812) · · 12,812 Disposed
Aug. 3, 2020 BBIO Stock Option (Right to Buy) Common Stock (10,000) $0.16 Aug. 26, 2028 10,000 Disposed
July 1, 2020 BBIO Stock Option (Right to Buy) Common Stock (10,000) $0.16 Aug. 26, 2028 10,000 Disposed
May 26, 2020 BBIO Stock Option (Right to Buy) Common Stock (18,365) $1.05 Dec. 17, 2029 18,365 Disposed
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (18,365) $1.05 Dec. 17, 2029 18,365 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (19,271) $2.29 June 24, 2028 19,271 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (45,027) $1.05 Sept. 24, 2029 45,027 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (13,932) $4.22 Sept. 24, 2029 13,932 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (3,351) $1.65 June 10, 2029 3,351 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (7,778) $4.13 May 28, 2029 7,778 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (39,487) $0.16 Aug. 26, 2028 39,487 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (1,019) $0.28 May 7, 2028 1,019 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (7,335) $0.28 Nov. 13, 2027 7,335 Acquired
May 19, 2020 BBIO Restricted Stock Units Common Stock (205,000) · · 205,000 Acquired
July 1, 2019 BBIO Management Incentive Units Common Stock (5,364) · · 5,364 Disposed
July 1, 2019 BBIO Management Incentive Units Common Stock (151,563) · · 151,563 Disposed
July 1, 2019 BBIO Management Incentive Units Common Stock (8,420) · · 8,420 Disposed
July 1, 2019 BBIO Management Incentive Units Common Stock (8,420) · · 8,420 Disposed

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 3 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
July 17, 2023 APGE Common Stock · Direct
July 13, 2023 APGE Common Stock · Direct
June 30, 2023 SYRE Stock Option (Right to Buy)→ Common Stock (1,950,000) 1,950,000 Direct

Compensation (DEF 14A)

08

Matched by name from proxy statements (DEF 14A) — verify against the filing.

Fiscal yearSalaryBonusStock awards Option awardsNon-equity incentivePension changeOtherTotal
2020 $515,000 $300,000 · · · · $11,843 $7,991,241

CIK 1974640

CEO
Fiscal yearSalaryBonusStock awards Option awardsNon-equity incentivePension changeOtherTotal
2023 $564,833 $606,375 · · · · · $8,671,208
2022 $145,833 $167,123 $6,079,410 · · · $56,750 $6,449,116

Figures from the Summary Compensation Table of the company's proxy statement (DEF 14A). Compensation is not a recommendation.