SYRE Spyre Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$105.64
Price · Aug 19, 2026
Fundamentals as of Aug 4, 2026
52W Range
$15–$110
95% of range
Analyst Rating
STRONG BUY
23 analysts
Price Target
$125
+18% upside
P/E (TTM)
33.0
ROE
-26.5%
Net Profit Margin
—

About Spyre Therapeutics, Inc. - Common Stock Company overview from Wikipedia

SYRE Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$105.64
Market Cap
$8.33B
P/E (TTM)
33.0
EPS (TTM)
$13.76
Revenue (TTM)
$0
Div Yield
—
ROE
-26.5%
Debt/Equity
—
52W Range
$15 – $110

SYRE Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $0
10-point trend, -100.0%
2016-12-31 → 2025-12-31
EPS $13.76
4-point trend, +1005.3%
2020-12-31 → 2023-12-31
Free Cash Flow —
9-point trend, -726.2%
2016-12-31 → 2024-12-31
Margins —

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
SYRE
Peer Median
P/E (TTM)
5-point trend, +313.7%
33.0
16.0
P/B
5-point trend, -94.7%
11.6
3.9

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
SYRE
Peer Median
ROA
5-point trend, +66.1%
-22.4%
-22.2%
ROE
5-point trend, +54.8%
-26.5%
-37.6%
ROIC
4-point trend, +62.6%
-29.3%
—

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
SYRE
Peer Median
Current Ratio
5-point trend, +45.5%
13.3
5.7
Quick Ratio
5-point trend, -73.3%
1.5
—

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
SYRE
Peer Median
Revenue YoY
5-point trend, -100.0%
-62.0%
—

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
SYRE
Peer Median
EPS (Diluted)
4-point trend, +1005.3%
$13.76
—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
SYRE
Peer Median

SYRE Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 23 analysts
  • Strong Buy 11 47.8%
  • Buy 10 43.5%
  • Hold 2 8.7%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

14 analysts · 2026-08-19
Median target $126.50 +19.7%
Mean target $124.71 +18.1%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.22%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.36 $-0.77 0.41%
March 31, 2026 $-0.74 $-0.68 -0.06%
Dec. 31, 2025 $-0.70 $-0.79 0.09%
Sept. 30, 2025 $-0.15 $-0.76 0.61%
June 30, 2025 $-0.77 $-0.77 -0.00%
March 31, 2025 $-0.60 $-0.86 0.26%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
SYRE $2.56B 10.1 -62.0% — -26.5% —
KYMR $6.33B -21.1 -16.7% -794.0% -24.4% —
APGE $5.16B -17.9 — — — —
KRYS $7.20B 36.0 33.9% 52.6% 18.1% —
IONS $12.92B -33.2 — — -68.1% —
IMVT $5.07B -9.0 229.2% — -73.7% —
PCVX $6.05B -8.2 — — -26.6% —
TWST $1.71B -21.6 20.3% -20.6% -17.0% —
IBRX $2.00B -5.2 668.3% -310.2% 71.0% —

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 14
Annual Income Statement data for SYRE
Metric Trend 2025202420232022202120202019201820172016
Revenue 10-point trend, -100.0% $0 $0 $886.0K $2M $19M $0 $0 $4M $5M $5M
R&D Expense 7-point trend, +222.9% · · · $59M $57M $60M $65M $37M $23M $18M
SG&A Expense 10-point trend, +471.0% $48M $46M $40M $29M $27M $22M $16M $13M $10M $8M
Operating Expenses 10-point trend, +689.8% $210M $209M $243M $87M $84M $81M $80M $49M $33M $27M
Operating Income 10-point trend, -856.6% $-210M $-209M $-242M $-85M $-66M $-81M $-80M $-45M $-28M $-22M
Other Non-op 10-point trend, +81930.6% $29M $-21M $-19M $-7.0K $-122.0K $-5.0K $-63.0K $-57.0K $-42.0K $-36.0K
Pretax Income 7-point trend, -98.4% $-155M $-208M $-339M $-84M $-66M $-81M $-78M · · ·
Income Tax 10-point trend, -15000.00 $-15.0K $51.0K $-26.0K $-136.0K $141.0K $0 $0 $0 $0 $0
Net Income 10-point trend, -615.3% $-155M $-208M $-339M $-84M $-66M $-81M $-78M $-44M $-27M $-22M
EPS (Basic) 4-point trend, +1005.3% · · $13.76 $-24.86 $-25.02 $-1.52 · · · ·
EPS (Diluted) 4-point trend, +1005.3% · · $13.76 $-24.86 $-25.02 $-1.52 · · · ·
Shares (Basic) 4-point trend, -87.1% · · 6,897,065 3,371,231 2,629,784 53,371,730 · · · ·
Shares (Diluted) 4-point trend, -87.1% · · 6,897,065 3,371,231 2,629,784 53,371,730 · · · ·
EBITDA 10-point trend, -862.4% $-210M $-209M $-242M $-83M $-64M $-80M $-80M $-45M $-27M $-22M
Balance Sheet 21
Annual Balance Sheet data for SYRE
Metric Trend 2025202420232022202120202019201820172016
Cash & Equivalents 10-point trend, +79.5% $86M $89M $189M $35M $15M $90M $19M $22M $13M $48M
Short-term Investments 3-point trend, +230.4% · · · · · · · $52M $37M $16M
Prepaid Expense 10-point trend, +1144.8% $21M $5M $2M $6M $5M $4M $3M $2M $2M $2M
Current Assets 10-point trend, +1070.9% $778M $608M $342M $62M $99M $150M $75M $77M $55M $66M
PP&E (Net) 8-point trend, -100.0% · · $0 $3M $5M $6M $2M $1M $854.0K $599.0K
PP&E (Gross) 8-point trend, -100.0% · · $0 $7M $7M $8M $3M $2M $1M $839.0K
Accum. Depreciation 8-point trend, -100.0% · · $0 $4M $3M $2M $1M $752.0K $487.0K $240.0K
Other Non-current Assets 10-point trend, -100.0% $0 $10.0K $9.0K $683.0K $842.0K $115.0K $67.0K $50.0K $232.0K $40.0K
Total Assets 10-point trend, +1059.8% $778M $608M $342M $71M $110M $162M $83M $78M $56M $67M
Accounts Payable 7-point trend, +303.0% · · · $677.0K $3M $2M $3M $663.0K $389.0K $168.0K
Current Liabilities 10-point trend, +1380.1% $59M $54M $32M $15M $20M $16M $18M $10M $6M $4M
Capital Leases 5-point trend, -100.0% · · $0 $4M $5M $5M $5M · · ·
Other Non-current Liabilities 8-point trend, -100.0% $0 · · $0 $16.0K $214.0K $31.0K $72.0K $111.0K $132.0K
Total Liabilities 10-point trend, +1426.6% $63M $91M $73M $21M $26M $22M $23M $10M $6M $4M
Common Stock 10-point trend, +1400.0% $15.0K $13.0K $10.0K $6.0K $5.0K $5.0K $3.0K $2.0K $2.0K $1.0K
Paid-in Capital 3-point trend, +70.3% · · · · · · · $184M $123M $108M
Retained Earnings 10-point trend, -2390.5% $-1.13B $-972M $-764M $-426M $-342M $-276M $-195M $-117M $-73M $-45M
AOCI 10-point trend, +21825.0% $869.0K $180.0K $302.0K $-48.0K $-20.0K $11.0K $51.0K $-27.0K $-102.0K $-4.0K
Stockholders' Equity 10-point trend, +1035.9% $715M $518M $184M $50M $84M $140M $60M $67M $50M $63M
Liabilities + Equity 10-point trend, +1059.8% $778M $608M $342M $71M $110M $162M $83M $78M $56M $67M
Shares Outstanding 10-point trend, +482.2% 78,189,811 60,257,000 36,057,000 2,614,000 1,974,000 1,918,000 29,084,437 24,140,097 16,670,188 13,430,833
Cash Flow 12
Annual Cash Flow data for SYRE
Metric Trend 2025202420232022202120202019201820172016
D&A 10-point trend, -100.0% $0 $0 $744.0K $2M $2M $996.0K $418.0K $293.0K $249.0K $132.0K
Stock-based Comp 10-point trend, +2980.6% $38M $45M $26M $7M $8M $6M $5M $4M $2M $1M
Other Non-cash 10-point trend, -3532.8% $-52M $6M $212M $-5M $2M $-2M $7M $8M $-120.0K $2M
Operating Cash Flow 10-point trend, -798.4% $-169M $-157M $-100M $-80M $-54M $-76M $-66M $-32M $-25M $-19M
CapEx 9-point trend, -100.0% · $0 $0 $38.0K $573.0K $4M $1M $422.0K $619.0K $212.0K
Investing Cash Flow 10-point trend, -1088.1% $-143M $-353M $-108M $57M $-23M $-8M $-2M $-15M $-23M $-12M
Stock Issued 3-point trend, +84555000.00 · · $85M $0 $0 · · · · ·
Net Stock Activity · · $85M · · · · · · ·
Financing Cash Flow 10-point trend, +525.9% $309M $411M $361M $43M $1M $155M $66M $57M $12M $49M
Net Change in Cash 10-point trend, -120.1% $-4M $-100M $153M $19M $-75M $71M $-2M $10M $-35M $18M
Taxes Paid $-15.0K · · · · · · · · ·
Free Cash Flow 9-point trend, -726.2% · $-157M $-100M $-80M $-54M $-80M $-67M $-33M $-25M $-19M
Profitability 7
Annual Profitability data for SYRE
Metric Trend 2025202420232022202120202019201820172016
Operating Margin 4-point trend, -2238.8% · · -27348.0% -3640.2% -350.3% · · -1169.3% · ·
Net Margin 4-point trend, -3252.3% · · -38238.2% -3598.7% -351.1% · · -1140.6% · ·
Pretax Margin 3-point trend, -10813.9% · · -38241.1% -3604.6% -350.4% · · · · ·
EBITDA Margin 4-point trend, -2246.7% · · -27264.0% -3573.0% -341.9% · · -1161.8% · ·
ROA 9-point trend, +45.5% -22.4% -43.8% · -92.6% -48.5% -66.1% -97.3% -66.3% -44.2% -41.0%
ROE 9-point trend, +75.1% -26.5% -49.2% · -142.2% -70.8% -58.6% -111.9% -67.7% -48.1% -106.5%
ROIC 4-point trend, +62.6% -29.3% -40.3% · -168.3% -78.4% · · · · ·
Liquidity & Solvency 2
Annual Liquidity & Solvency data for SYRE
Metric Trend 2025202420232022202120202019201820172016
Current Ratio 9-point trend, -20.9% 13.3 11.3 · 4.2 4.9 9.1 4.1 7.5 9.8 16.8
Quick Ratio 9-point trend, -90.9% 1.5 1.7 · 2.4 0.8 5.5 1.0 7.3 8.9 16.0
Efficiency 1
Annual Efficiency data for SYRE
Metric Trend 2025202420232022202120202019201820172016
Asset Turnover 7-point trend, -100.0% 0.0 0.0 · 0.0 0.1 0.0 0.0 0.1 · ·
Per Share 5
Annual Per Share data for SYRE
Metric Trend 2025202420232022202120202019201820172016
Book Value / Share 9-point trend, +95.1% $9.15 $8.59 · $0.77 $1.70 $2.92 $2.07 $2.79 $3.02 $4.69
Revenue / Share 2-point trend, +365.6% · · $0.13 $0.03 · · · · · ·
Cash Flow / Share 2-point trend, -1423.4% · · $-14.49 $-0.95 · · · · · ·
Cash / Share 9-point trend, -69.2% $1.10 $1.48 · $0.53 $0.31 $1.88 $0.66 $0.93 $0.77 $3.56
EPS (TTM) 6-point trend, +312.5% $3.23 $3.23 $13.76 $-24.86 $-25.02 $-1.52 · · · ·
Growth Rates 1
Annual Growth Rates data for SYRE
Metric Trend 2025202420232022202120202019201820172016
Revenue YoY 2-point trend, +29.2% · · -62.0% -87.6% · · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for SYRE
Metric Trend 2025202420232022202120202019201820172016
Revenue TTM 10-point trend, -100.0% $0 $0 $886.0K $2M $19M $0 $0 $4M $5M $5M
Net Income TTM 10-point trend, -615.3% $-155M $-208M $-339M $-84M $-66M $-81M $-78M $-44M $-27M $-22M
Market Cap 9-point trend, +75.4% $2.56B $1.40B · $735M $5.86B $9.44B $5.56B $4.52B $2.25B $1.46B
P/E 6-point trend, +107.8% 10.1 7.2 1.6 -0.5 -4.7 -129.4 · · · ·
P/S 5-point trend, +0.0% · · · 315.7 312.8 · · 1162.6 433.2 315.6
P/B 9-point trend, -84.6% 3.6 2.7 · 14.6 69.8 67.5 92.5 67.0 44.8 23.2
P / Tangible Book 6-point trend, -94.7% 3.6 2.7 4.2 14.6 69.8 67.5 · · · ·
P / Cash Flow 9-point trend, +80.5% -15.1 -8.9 · -9.2 -109.1 -124.5 -84.6 -140.4 -91.6 -77.5
P / FCF 8-point trend, +88.4% · -8.9 · -9.2 -108.0 -117.9 -82.7 -138.6 -89.3 -76.7
Earnings Yield 6-point trend, +1380.5% 9.9% 13.9% 63.9% -221.0% -21.1% -0.77% · · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $0$0$886.0K$2M$19M
Operating Margin % ——-27348.0%-3640.2%-350.3%
Net Income $-155M$-208M$-339M$-84M$-66M
Diluted EPS ——$13.76$-24.86$-25.02
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 13.311.3—4.24.9
Quick Ratio 1.51.7—2.40.8
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow —$-157M$-100M$-80M$-54M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 277 filers · $6.3B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
99 (+45 vs prior Q) 20 (+9 vs prior Q) 90 (+28 vs prior Q) 60 (+11 vs prior Q) +13.6M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FMR LLC $809,889,779 9,122,435 12.77% Shares
PERCEPTIVE ADVISORS LLC $383,484,855 4,319,496 6.04% Shares
RTW INVESTMENTS, LP $377,492,205 4,251,996 5.95% Shares
Paradigm Biocapital Advisors LP $340,984,271 3,840,778 5.37% Shares
VANGUARD CAPITAL MANAGEMENT LLC $306,173,899 3,448,681 4.83% Shares
STATE STREET CORP $271,437,392 3,057,416 4.28% Shares
Venrock Adviser, LLC $265,048,073 2,985,448 4.18% Shares
Driehaus Capital Management LLC $248,509,957 2,799,166 3.92% Shares
GEODE CAPITAL MANAGEMENT, LLC $214,266,641 2,280,766 3.38% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $206,866,100 2,330,098 3.26% Shares
Capital World Investors $205,574,795 2,315,553 3.24% Shares
TCG Crossover Management, LLC $168,733,670 1,900,582 2.66% Shares
TANG CAPITAL MANAGEMENT LLC $167,989,516 1,892,200 2.65% Shares
BANK OF AMERICA CORP /DE/ $153,183,764 1,725,431 2.41% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $152,905,794 1,722,300 2.41% Shares
Remedium Capital Partners, LLC $129,988,924 1,464,169 2.05% Shares
Affinity Asset Advisors, LLC $113,561,517 1,279,134 1.79% Shares
WELLINGTON MANAGEMENT GROUP LLP $93,139,364 1,049,103 1.47% Shares
Holocene Advisors, LP $90,126,793 1,015,170 1.42% Shares
Polar Capital Holdings Plc $87,715,439 988,009 1.38% Shares
Siren, L.L.C. $85,992,130 968,598 1.36% Shares
Capital International Investors $84,802,301 955,196 1.34% Shares
BRAIDWELL LP $78,079,080 879,467 1.23% Shares
Commodore Capital LP $75,177,661 846,786 1.18% Shares
GOLDMAN SACHS GROUP INC $72,714,194 819,038 1.15% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $57,969,611 652,958 0.91% Shares
Pictet Asset Management Holding SA $55,766,092 628,138 0.88% Shares
EMERALD ADVISERS, LLC $50,376,435 567,430 0.79% Shares
VICTORY CAPITAL MANAGEMENT INC $49,182,345 553,980 0.78% Shares
VANGUARD FIDUCIARY TRUST CO $48,952,315 551,389 0.77% Shares
Candriam S.C.A. $48,454,915 546,312 0.76% Shares
EMERALD MUTUAL FUND ADVISERS TRUST $35,624,839 401,271 0.56% Shares
AMERIPRISE FINANCIAL INC $30,737,766 346,224 0.48% Shares
Integral Health Asset Management, LLC $28,853,500 325,000 0.45% Shares
Woodline Partners LP $27,171,030 306,049 0.43% Shares
JENNISON ASSOCIATES LLC $26,916,321 303,180 0.42% Shares
ADAR1 Capital Management, LLC $25,211,922 283,982 0.40% Shares
BNP PARIBAS FINANCIAL MARKETS $23,075,964 259,923 0.36% Shares
Cormorant Asset Management, LP $19,975,500 225,000 0.31% Shares
SEVEN GRAND MANAGERS, LLC $19,975,500 225,000 0.31% Shares
EVENTIDE ASSET MANAGEMENT, LLC $17,901,699 201,616 0.28% Shares
MILLENNIUM MANAGEMENT LLC $17,464,091 196,712 0.28% Shares
MARSHALL WACE, LLP $17,267,533 194,498 0.27% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $16,903,712 190,400 0.27% Put option
ORBIMED ADVISORS LLC $16,525,953 186,145 0.26% Shares
FRONTIER CAPITAL MANAGEMENT CO LLC $16,240,614 182,931 0.26% Shares
Caption Management, LLC $15,421,086 173,700 0.24% Put option
Universal- Beteiligungs- und Servicegesellschaft mbH $15,352,104 172,923 0.24% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $13,778,656 155,200 0.22% Call option
SAMLYN CAPITAL, LLC $13,557,239 152,706 0.21% Shares
Balyasny Asset Management L.P. $13,054,389 147,042 0.21% Shares
Soleus Capital Management, L.P. $13,050,660 147,000 0.21% Shares
Squarepoint Ops LLC $12,394,132 139,605 0.20% Shares
ARMISTICE CAPITAL, LLC $12,215,063 137,588 0.19% Shares
Ensign Peak Advisors, Inc $11,241,324 126,620 0.18% Shares
NEUBERGER BERMAN GROUP LLC $10,734,656 120,913 0.17% Shares
Blackstone Inc. $10,669,314 120,177 0.17% Shares
Rhenman & Partners Asset Management AB $10,591,454 119,300 0.17% Shares
TD Asset Management Inc $10,297,592 115,990 0.16% Shares
Swiss National Bank $9,987,750 112,500 0.16% Shares
STEMPOINT CAPITAL LP $9,492,890 106,926 0.15% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $9,278,930 104,516 0.15% Shares
Boxer Capital Management, LLC $8,878,000 100,000 0.14% Shares
RHUMBLINE ADVISERS $8,413,043 94,763 0.13% Shares
F/m Investments LLC $8,222,626 92,618 0.13% Shares
BARCLAYS PLC $8,187,292 92,220 0.13% Shares
FEDERATED HERMES, INC. $7,630,641 85,950 0.12% Shares
Granahan Investment Management, LLC $7,367,941 82,991 0.12% Shares
CITIGROUP INC $6,950,941 78,294 0.11% Shares
HighVista Strategies LLC $6,907,706 77,807 0.11% Shares
VOYA INVESTMENT MANAGEMENT LLC $6,758,821 76,130 0.11% Shares
BlackRock, Inc. $6,744,883 75,973 0.11% Shares
MERCER GLOBAL ADVISORS INC /ADV $6,316,253 71,145 0.10% Shares
PRUDENTIAL FINANCIAL INC $6,247,449 70,370 0.10% Shares
B Group, Inc. $6,214,600 70,000 0.10% Shares
Trexquant Investment LP $5,948,881 67,007 0.09% Shares
CITADEL ADVISORS LLC $5,497,258 61,920 0.09% Shares
Informed Momentum Co LLC $5,361,691 60,393 0.08% Shares
SILVERARC CAPITAL MANAGEMENT, LLC $5,323,160 59,959 0.08% Shares
Hudson Bay Capital Management LP $5,183,598 58,387 0.08% Shares
Atle Fund Management AB $5,063,123 57,030 0.08% Shares
PRINCIPAL FINANCIAL GROUP INC $4,798,737 54,052 0.08% Shares
Susquehanna Portfolio Strategies, LLC $4,714,307 53,101 0.07% Shares
ALLIANCEBERNSTEIN L.P. $4,667,718 92,540 0.07% Shares
ROYCE & ASSOCIATES LP $4,597,827 51,789 0.07% Shares
XTX Topco Ltd $4,481,881 50,483 0.07% Shares
Monashee Investment Management LLC $4,439,000 50,000 0.07% Shares
Cinctive Capital Management LP $4,348,267 48,978 0.07% Shares
DIMENSIONAL FUND ADVISORS LP $4,234,628 47,698 0.07% Shares
PFM Health Sciences, LP $4,103,145 46,217 0.06% Shares
STATE OF WISCONSIN INVESTMENT BOARD $3,997,763 45,030 0.06% Shares
SCHRODER INVESTMENT MANAGEMENT GROUP $3,989,580 44,250 0.06% Shares
CITADEL ADVISORS LLC $3,888,564 43,800 0.06% Call option
MetLife Investment Management, LLC $3,845,594 43,316 0.06% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $3,824,000 43,071 0.06% Shares
Moody Aldrich Partners LLC $3,769,421 42,458 0.06% Shares
Rock Springs Capital Management LP $3,751,310 42,254 0.06% Shares
JANE STREET GROUP, LLC $3,666,614 41,300 0.06% Call option
Maven Securities LTD $3,551,200 40,000 0.06% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $3,490,031 39,311 0.06% Shares

Company insiders 35 insiders · 18 officers · 17 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Jeff Marc Goldberg President and CEO Nov. 29, 2022 A — 0 0 $0
Anthony G. Quinn President & CEO March 16, 2022 P 550,540 0 0 $0
David George Lowe CEO and President March 20, 2017 A 5,658 0 0 $0
Jonathan Alspaugh President and CFO June 22, 2023 A 165,372 0 0 $0
Charles N York II Chief Financial Officer and VP Feb. 20, 2018 A 34,787 0 0 $0
Leslie Sloan Chief Operating Officer Aug. 23, 2022 A — 0 0 $0
Sheldon Sloan Chief Medical Officer July 1, 2026 M 0 0 3 $-1,355,871
Heidy King-Jones Chief Legal Officer and Corporate Secretary Feb. 1, 2024 A — 0 0 $0
Linda L Neuman Chief Medical Officer Feb. 23, 2023 A — 0 0 $0
James Paul Kastenmayer General Counsel Feb. 23, 2023 A — 0 0 $0
Jr. Michael Conick Hanley Chief Business Officer Feb. 23, 2023 A 36,200 0 0 $0
Steven Weber VP, Controller&Princ Acctg Off Feb. 17, 2022 A — 0 0 $0
James Wooldridge Chief Medical Officer Feb. 20, 2018 A — 0 0 $0
Aaron Schuchart Chief Business Officer Feb. 20, 2018 A — 0 0 $0
Scott W Rowlinson VP, Research Aug. 22, 2017 A 11,204 0 0 $0
Joseph E Tyler VP, Manufacturing Aug. 22, 2017 A 42,428 0 0 $0
Henry Hebel VP, Product Development March 20, 2017 A — 0 0 $0
Sandra Rojas-Caro Chief Medical Officer May 17, 2016 A — 0 0 $0
Michael Thomas Henderson Director June 22, 2026 S 68,606 0 1 $-2,000,000
Sandra Milligan Director May 14, 2024 A — 0 0 $0
Laurie Stelzer Director May 14, 2024 A — 0 0 $0
Mark C. Mckenna Director Feb. 1, 2024 A — 0 0 $0
Hunter C Smith Director June 22, 2023 A — 0 0 $0
Alison Frances Lawton Director June 22, 2023 A — 0 0 $0
Russell J. Cox Director June 22, 2023 A 7,000 0 0 $0
Ivana Magovcevic-Liebisch Director June 22, 2023 A — 0 0 $0
Marcio Souza Director Aug. 25, 2022 P 90,000 0 0 $0
Armen Shanafelt Director June 7, 2022 A 150,000 0 0 $0
Sandesh Mahatme Director June 7, 2022 A — 0 0 $0
Bryan V Lawlis Director June 7, 2022 A — 0 0 $0
Suzanne Louise Bruhn Director June 8, 2020 A — 0 0 $0
George Georgiou Director June 7, 2018 A — 0 0 $0
Jeffrey W. Albers — Aug. 7, 2026 M 9,360 0 3 $-2,404,190
Scott L Burrows — Aug. 3, 2026 M 97,994 0 10 $-3,214,747
Cameron Turtle — Aug. 3, 2026 S 567,540 0 11 $-3,804,537

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Fairmount Funds Management LLC, Fairmount Healthcare Fund II L.P., Peter Evan Harwin, Tomas Kiselak ×8 filings June 23, 2026 9.99% Amendment Board campaign SEC
Baker Bros. Advisors LP, Baker Bros. Advisors (GP) LLC, Felix J. Baker, Julian C. Baker ×3 filings Feb. 10, 2022 — Initial filing Board campaign SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 52 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
LFSC · RBB Fund, Inc. 6.41% 91,588 NS May 31, 2026 N-PORT
SBIO · ALPS ETF Trust 3.68% 80,958 NS May 31, 2026 N-PORT
PTH · Invesco Exchange-Traded Fund Trust 2.06% 48,603 SH Aug. 8, 2026 Daily
BBC · ETFis Series Trust I 1.64% 8,208 NS April 30, 2026 N-PORT
JDOC · J.P. Morgan Exchange-Traded Fund Tr… 0.89% 1,327 NS April 30, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.88% 61,270 NS April 30, 2026 N-PORT
MMSC · First Trust Exchange-Traded Fund VI… 0.80% 5,695 NS May 31, 2026 N-PORT
DWAS · Invesco Exchange-Traded Fund Trust … 0.62% 26,650 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.62% 4,726 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.62% 567,384 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.48% 674,957 SH Aug. 8, 2026 Daily
ESSC · Strategy Shares 0.44% 1,513 NS April 30, 2026 N-PORT
VTWG · VANGUARD SCOTTSDALE FUNDS 0.39% 79,707 SH Aug. 8, 2026 Daily
GDOC · Goldman Sachs ETF Trust 0.35% 960 NS May 31, 2026 N-PORT
GSC · Goldman Sachs ETF Trust 0.33% 11,214 NS May 31, 2026 N-PORT
BIB · ProShares Trust 0.29% 2,905 NS May 31, 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.25% 24,522 NS April 30, 2026 N-PORT
IWM · iShares Trust 0.24% 1,888,627 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.20% 428,619 SH Aug. 8, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.18% 39,684 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.17% 32,342 NS April 30, 2026 N-PORT
ISCV · iShares Trust 0.16% 10,829 SH Aug. 8, 2026 Daily
ITWO · ProShares Trust 0.14% 3,514 NS May 31, 2026 N-PORT
ISCB · iShares Trust 0.12% 3,446 SH Aug. 8, 2026 Daily
SCHA · SCHWAB STRATEGIC TRUST 0.12% 360,437 NS May 31, 2026 N-PORT
ESML · iShares Trust 0.10% 28,847 SH Aug. 8, 2026 Daily
GSSC · Goldman Sachs ETF Trust 0.09% 12,695 NS May 31, 2026 N-PORT
ISCG · iShares Trust 0.09% 8,788 SH Aug. 8, 2026 Daily
SMLF · iShares Trust 0.09% 36,934 SH Aug. 8, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.08% 22,580 SH Aug. 8, 2026 Daily
UWM · ProShares Trust 0.08% 2,748 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.08% 886,783 SH Aug. 8, 2026 Daily
SMMV · iShares Trust 0.07% 2,062 SH Aug. 8, 2026 Daily
VBR · VANGUARD INDEX FUNDS 0.07% 568,910 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.07% 168,446 SH Aug. 8, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.06% 22,417 NS April 30, 2026 N-PORT
URTY · ProShares Trust 0.06% 2,782 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.05% 3,511 SH Aug. 8, 2026 Daily
FMED · Fidelity Covington Trust 0.05% 300 NS May 31, 2026 N-PORT
AVIE · AMERICAN CENTURY ETF TRUST 0.05% 75 NS May 31, 2026 N-PORT
VB · VANGUARD INDEX FUNDS 0.04% 896,639 SH Aug. 8, 2026 Daily
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.03% 2,863 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.02% 70 NS May 31, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.02% 24,878 NS May 31, 2026 N-PORT
TILT · FlexShares Trust 0.01% 4,004 NS April 30, 2026 N-PORT
ITOT · iShares Trust 0.01% 103,106 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.01% 19,865 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.01% 2,482,796 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.01% 6,117 SH Aug. 8, 2026 Daily
SCHB · SCHWAB STRATEGIC TRUST 0.01% 44,082 NS May 31, 2026 N-PORT