Insider at

04

Insider transactions

05
0 buys (P) 60 sells (S) Net: $-20,420,978 + 26 non-open-market transactions below 12 months to the week close of 2026-10-23

Price change vs the latest weekly close (updated to the current quote in your browser when available), split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

26 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
March 4, 2026 ALNY S 135 $319.03 $43,069 98,493 Direct -0.14% Disposed -29.8% (price as of )
March 4, 2026 ALNY S 129 $320.01 $41,281 98,364 Direct -0.13% Disposed -30.0% (price as of )
March 4, 2026 ALNY S 274 $320.81 $87,902 98,090 Direct -0.28% Disposed -30.2% (price as of )
March 4, 2026 ALNY S 368 $321.82 $118,430 97,722 Direct -0.38% Disposed -30.4% (price as of )
March 4, 2026 ALNY S 444 $323.01 $143,416 97,278 Direct -0.45% Disposed -30.6% (price as of )
March 4, 2026 ALNY S 973 $323.84 $315,096 96,305 Direct -1.00% Disposed -30.8% (price as of )
March 4, 2026 ALNY S 345 $324.88 $112,084 95,960 Direct -0.36% Disposed -31.0% (price as of )
March 4, 2026 ALNY S 265 $325.67 $86,303 95,695 Direct -0.28% Disposed -31.2% (price as of )
March 2, 2026 ALNY S 200 $323.62 $64,724 105,227 Direct -0.19% Disposed -30.8% (price as of )
March 2, 2026 ALNY S 382 $324.65 $124,016 104,845 Direct -0.36% Disposed -31.0% (price as of )
March 2, 2026 ALNY S 1,098 $325.63 $357,542 103,747 Direct -1.05% Disposed -31.2% (price as of )
March 2, 2026 ALNY S 1,669 $326.81 $545,446 102,078 Direct -1.61% Disposed -31.4% (price as of )
March 2, 2026 ALNY S 1,399 $327.67 $458,410 100,679 Direct -1.37% Disposed -31.6% (price as of )
March 2, 2026 ALNY S 424 $328.71 $139,373 100,255 Direct -0.42% Disposed -31.8% (price as of )
March 2, 2026 ALNY S 722 $329.71 $238,051 99,533 Direct -0.72% Disposed -32.1% (price as of )
March 2, 2026 ALNY S 346 $330.85 $114,474 99,187 Direct -0.35% Disposed -32.3% (price as of )
March 2, 2026 ALNY S 399 $331.93 $132,440 98,788 Direct -0.40% Disposed -32.5% (price as of )
March 2, 2026 ALNY S 160 $332.64 $53,222 98,628 Direct -0.16% Disposed -32.7% (price as of )
Feb. 13, 2026 ALNY S 6,958 $310.08 $2,157,537 85,662 Direct -7.51% Disposed -27.8% (price as of )
Jan. 12, 2026 ALNY S 247 $353.95 $87,426 87,741 Direct -0.28% Disposed -36.7% (price as of )
Jan. 12, 2026 ALNY S 269 $355.16 $95,538 87,472 Direct -0.31% Disposed -36.9% (price as of )
Jan. 12, 2026 ALNY S 263 $356.09 $93,652 87,209 Direct -0.30% Disposed -37.1% (price as of )
Jan. 12, 2026 ALNY S 607 $357.17 $216,802 86,602 Direct -0.70% Disposed -37.3% (price as of )
Jan. 12, 2026 ALNY S 778 $358.18 $278,664 85,824 Direct -0.90% Disposed -37.5% (price as of )
Jan. 12, 2026 ALNY S 537 $359.14 $192,858 85,287 Direct -0.63% Disposed -37.6% (price as of )
Jan. 12, 2026 ALNY S 980 $360.22 $353,016 84,307 Direct -1.15% Disposed -37.8% (price as of )
Jan. 12, 2026 ALNY S 624 $361.45 $225,545 83,683 Direct -0.74% Disposed -38.0% (price as of )
Jan. 12, 2026 ALNY S 464 $362.38 $168,144 83,219 Direct -0.55% Disposed -38.2% (price as of )
Jan. 12, 2026 ALNY S 301 $363.55 $109,429 82,918 Direct -0.36% Disposed -38.4% (price as of )
Jan. 12, 2026 ALNY S 1,259 $364.83 $459,321 81,659 Direct -1.52% Disposed -38.6% (price as of )
Jan. 12, 2026 ALNY S 1,395 $365.56 $509,956 80,264 Direct -1.71% Disposed -38.7% (price as of )
Jan. 12, 2026 ALNY S 316 $366.41 $115,786 79,948 Direct -0.39% Disposed -38.9% (price as of )
Jan. 12, 2026 ALNY S 261 $367.40 $95,891 79,687 Direct -0.33% Disposed -39.0% (price as of )
Jan. 12, 2026 ALNY S 584 $368.62 $215,274 79,103 Direct -0.73% Disposed -39.2% (price as of )
Jan. 12, 2026 ALNY S 253 $369.48 $93,478 78,850 Direct -0.32% Disposed -39.4% (price as of )
Jan. 12, 2026 ALNY S 118 $370.87 $43,763 78,732 Direct -0.15% Disposed -39.6% (price as of )
Jan. 12, 2026 ALNY S 21 $372.46 $7,822 78,711 Direct -0.03% Disposed -39.9% (price as of )
Jan. 12, 2026 ALNY S 88 $374.44 $32,951 78,623 Direct -0.11% Disposed -40.2% (price as of )
Jan. 12, 2026 ALNY S 118 $375.65 $44,327 78,505 Direct -0.15% Disposed -40.4% (price as of )
Jan. 12, 2026 ALNY S 94 $377.82 $35,515 78,411 Direct -0.12% Disposed -40.7% (price as of )
Nov. 13, 2025 ALNY S 10b5-1 654 $447.73 $292,815 74,755 Direct -0.87% Disposed -50.0% (price as of )
Nov. 13, 2025 ALNY S 10b5-1 1,013 $448.76 $454,594 73,742 Direct -1.36% Disposed -50.1% (price as of )
Nov. 13, 2025 ALNY S 10b5-1 1,477 $450.02 $664,680 72,265 Direct -2.00% Disposed -50.2% (price as of )
Nov. 13, 2025 ALNY S 10b5-1 2,218 $450.69 $999,630 70,047 Direct -3.07% Disposed -50.3% (price as of )
Nov. 13, 2025 ALNY S 10b5-1 1,702 $451.94 $769,202 68,345 Direct -2.43% Disposed -50.4% (price as of )
Nov. 13, 2025 ALNY S 10b5-1 1,599 $452.85 $724,107 66,746 Direct -2.34% Disposed -50.5% (price as of )
Nov. 13, 2025 ALNY S 10b5-1 881 $453.99 $399,965 65,865 Direct -1.32% Disposed -50.7% (price as of )
Nov. 13, 2025 ALNY S 10b5-1 195 $454.69 $88,665 65,670 Direct -0.30% Disposed -50.7% (price as of )
Nov. 13, 2025 ALNY S 10b5-1 261 $456.03 $119,024 65,409 Direct -0.40% Disposed -50.9% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 711 $448.07 $318,578 80,348 Direct -0.88% Disposed -50.0% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 2,132 $449.15 $957,588 78,216 Direct -2.65% Disposed -50.1% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 453 $450.17 $203,927 77,763 Direct -0.58% Disposed -50.2% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 1,255 $451.16 $566,206 76,508 Direct -1.61% Disposed -50.3% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 1,210 $452.43 $547,440 75,298 Direct -1.58% Disposed -50.5% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 1,069 $453.52 $484,813 74,229 Direct -1.42% Disposed -50.6% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 1,960 $454.84 $891,486 72,269 Direct -2.64% Disposed -50.7% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 3,406 $455.56 $1,551,637 68,863 Direct -4.71% Disposed -50.8% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 2,420 $456.64 $1,105,069 66,443 Direct -3.51% Disposed -50.9% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 604 $457.71 $276,457 65,839 Direct -0.91% Disposed -51.1% (price as of )
Nov. 12, 2025 ALNY S 10b5-1 430 $458.42 $197,121 65,409 Direct -0.65% Disposed -51.1% (price as of )
Oct. 2, 2025 ALNY S 350 $446.53 $156,286 73,983 Direct -0.47% Disposed -49.8% (price as of )
Oct. 2, 2025 ALNY S 171 $447.92 $76,594 73,812 Direct -0.23% Disposed -50.0% (price as of )
Oct. 2, 2025 ALNY S 548 $448.77 $245,926 73,264 Direct -0.74% Disposed -50.1% (price as of )
Oct. 2, 2025 ALNY S 758 $449.79 $340,941 72,506 Direct -1.03% Disposed -50.2% (price as of )
Oct. 2, 2025 ALNY S 1,642 $450.81 $740,230 70,864 Direct -2.26% Disposed -50.3% (price as of )
Oct. 2, 2025 ALNY S 1,010 $451.86 $456,379 69,854 Direct -1.43% Disposed -50.4% (price as of )
Oct. 2, 2025 ALNY S 2,029 $452.69 $918,508 67,825 Direct -2.90% Disposed -50.5% (price as of )
Oct. 2, 2025 ALNY S 999 $453.77 $453,316 66,826 Direct -1.47% Disposed -50.6% (price as of )
Oct. 2, 2025 ALNY S 741 $454.84 $337,036 66,085 Direct -1.11% Disposed -50.7% (price as of )
Oct. 2, 2025 ALNY S 221 $455.82 $100,736 65,864 Direct -0.33% Disposed -50.9% (price as of )
Oct. 2, 2025 ALNY S 446 $457.43 $204,014 65,418 Direct -0.68% Disposed -51.0% (price as of )
Oct. 2, 2025 ALNY S 9 $457.64 $4,119 65,409 Direct -0.01% Disposed -51.0% (price as of )
Aug. 18, 2025 ALNY S 194 $447.98 $86,908 63,006 Direct -0.31% Disposed -50.0% (price as of )
Aug. 18, 2025 ALNY S 450 $449.92 $202,464 62,556 Direct -0.71% Disposed -50.2% (price as of )

Loaded 100 of 361 rows

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
March 2, 2026 ALNY Stock Option (right to buy) Common Stock (30,425) $325.07 March 2, 2036 30,425 Acquired
March 2, 2026 ALNY Stock Price Performance Stock Unit Common Stock $0.00 · 110,746 Acquired
Feb. 27, 2026 ALNY Restricted Stock Units Common Stock (5,921) · · 5,921 Disposed
Nov. 26, 2025 ALNY Stock Option (right to buy) Common Stock (2,352) $85.00 Feb. 27, 2029 2,352 Disposed
Nov. 26, 2025 ALNY Stock Option (right to buy) Common Stock (847) $118.05 Feb. 25, 2030 847 Disposed
Nov. 26, 2025 ALNY Stock Option (right to buy) Common Stock (839) $119.13 Feb. 28, 2028 839 Disposed
Nov. 26, 2025 ALNY Stock Option (right to buy) Common Stock (659) $151.59 Feb. 23, 2031 659 Disposed
Nov. 13, 2025 ALNY Performance Stock Option 2017 (right to buy) Common Stock (10,000) $119.13 March 1, 2028 10,000 Disposed
Nov. 12, 2025 ALNY Performance Stock Option 2016 (right to buy) Common Stock (650) $42.22 Dec. 20, 2026 650 Disposed
Nov. 12, 2025 ALNY Performance Stock Option 2017 (right to buy) Common Stock (15,000) $119.13 March 1, 2028 15,000 Disposed
June 2, 2025 ALNY Stock Option (right to buy) Common Stock (7,217) $118.05 Feb. 25, 2030 7,217 Disposed
June 2, 2025 ALNY Stock Option (right to buy) Common Stock (12,080) $119.13 Feb. 28, 2028 12,080 Disposed
May 30, 2025 ALNY Stock Option (right to buy) Common Stock (19,559) $118.05 Feb. 25, 2030 19,559 Disposed
May 30, 2025 ALNY Stock Option (right to buy) Common Stock (12,081) $119.13 Feb. 28, 2028 12,081 Disposed
March 3, 2025 ALNY Stock Option (right to buy) Common Stock (36,293) $243.53 March 3, 2035 36,293 Acquired
Feb. 27, 2025 ALNY Restricted Stock Units Common Stock (5,921) · · 5,921 Disposed
Aug. 20, 2024 ALNY Stock Option (right to buy) Common Stock (15,000) $85.00 Feb. 27, 2029 15,000 Disposed
Aug. 1, 2024 ALNY Stock Option (right to buy) Common Stock (15,148) $85.00 Feb. 27, 2029 15,148 Disposed
March 1, 2024 ALNY Stock Option (right to buy) Common Stock (46,394) $152.61 March 1, 2034 46,394 Acquired
Feb. 27, 2024 ALNY Restricted Stock Units Common Stock (5,921) · · 5,921 Disposed
Feb. 27, 2023 ALNY Restricted Stock Units Common Stock (17,763) · Feb. 27, 2026 17,763 Acquired
Feb. 27, 2023 ALNY Stock Option (right to buy) Common Stock (36,775) $190.01 Feb. 27, 2033 36,775 Acquired
June 8, 2022 PCRX Stock Option (Right to Buy) Common Stock (8,225) $59.39 June 8, 2032 8,225 Acquired
Feb. 23, 2022 ALNY Stock Option (right to buy) Common Stock (31,747) $147.47 Feb. 22, 2032 31,747 Acquired
Dec. 31, 2021 ALNY Stock Option (right to buy) Common Stock (55,949) $169.58 Dec. 30, 2031 55,949 Acquired
Aug. 6, 2021 ALNY Performance Stock Option 2016 (right to buy) Common Stock (25,000) $77.10 Sept. 18, 2026 25,000 Disposed
Aug. 6, 2021 ALNY Stock Option (right to buy) Common Stock (28,064) $77.10 Sept. 18, 2026 28,064 Disposed
June 9, 2021 PCRX Stock Option (Right to Buy) Common Stock (7,626) $60.96 June 9, 2031 7,626 Acquired
Feb. 24, 2021 ALNY Stock Option (right to buy) Common Stock (28,800) $151.59 Feb. 23, 2031 28,800 Acquired
Feb. 11, 2021 ALNY Performance Stock Option 2017 (right to buy) Common Stock (8,334) $119.13 March 1, 2028 8,334 Acquired
Jan. 12, 2021 ALNY Stock Option (right to buy) Common Stock (3,125) $42.22 Dec. 20, 2026 3,125 Disposed
July 10, 2020 ALNY Stock Option (right to buy) Common Stock (46,639) $77.10 Sept. 18, 2026 46,639 Disposed
July 9, 2020 ALNY Stock Option (right to buy) Common Stock (10,939) $42.22 Dec. 20, 2026 10,939 Disposed
July 9, 2020 ALNY Stock Option (right to buy) Common Stock (297) $77.10 Sept. 18, 2026 297 Disposed
June 9, 2020 PCRX Stock Option (Right to Buy) Common Stock (8,027) $47.65 June 9, 2030 8,027 Acquired
May 6, 2020 ALNY Stock Option (right to buy) Common Stock (50,000) $77.10 Sept. 18, 2026 50,000 Disposed
May 5, 2020 ALNY Performance Stock Option 2016 (right to buy) Common Stock (6,250) $42.22 Dec. 20, 2026 6,250 Disposed
May 5, 2020 ALNY Stock Option (right to buy) Common Stock (1,561) $42.22 Dec. 20, 2026 1,561 Disposed
Feb. 26, 2020 ALNY Stock Option (right to buy) Common Stock (27,623) $118.05 Feb. 25, 2030 27,623 Acquired
Feb. 10, 2020 ALNY Performance Stock Option 2016 (right to buy) Common Stock (5,600) $42.22 Dec. 20, 2026 5,600 Disposed
Feb. 7, 2020 ALNY Performance Stock Option 2016 (right to buy) Common Stock (6,250) $42.22 Dec. 20, 2026 6,250 Disposed
Dec. 23, 2019 ALNY Performance Stock Option 2017 (right to buy) Common Stock (8,333) $119.13 March 1, 2028 8,333 Acquired
Nov. 22, 2019 ALNY Performance Stock Option 2017 (right to buy) Common Stock (8,333) $119.13 March 1, 2028 8,333 Acquired
Nov. 20, 2019 ALNY Performance Stock Option 2016 (right to buy) Common Stock (6,250) $42.22 Dec. 20, 2026 6,250 Disposed
Nov. 20, 2019 ALNY Stock Option (right to buy) Common Stock (2,154) $42.22 Dec. 20, 2026 2,154 Disposed
Aug. 6, 2019 ALNY Performance Stock Option 2016 (right to buy) Common Stock (6,250) $42.22 Dec. 20, 2026 6,250 Acquired
June 5, 2019 ALNY Performance Stock Option 2016 (right to buy) Common Stock (6,250) $42.22 Dec. 20, 2026 6,250 Acquired
June 5, 2019 PCRX Stock Option (Right to Buy) Common Stock (8,437) $43.54 June 5, 2029 8,437 Acquired
Feb. 28, 2019 ALNY Stock Option (right to buy) Common Stock (32,500) $85.00 Feb. 27, 2029 32,500 Acquired
Sept. 27, 2018 ALNY Performance Stock Option 2016 (right to buy) Common Stock (6,250) $42.22 Dec. 20, 2026 6,250 Acquired
Aug. 13, 2018 ALNY Performance Stock Option 2016 (right to buy) Common Stock (25,000) $77.10 Sept. 19, 2026 25,000 Acquired
June 13, 2018 PCRX Stock Option (Right to Buy) Common Stock (4,693) $38.35 June 13, 2028 4,693 Acquired
March 26, 2018 ALNY Stock Option (right to buy) Common Stock (7,221) $42.22 Dec. 20, 2026 7,221 Disposed
March 1, 2018 ALNY Stock Option (right to buy) Common Stock (25,000) $119.13 Feb. 28, 2028 25,000 Acquired
Dec. 20, 2017 ALNY Performance Stock Option 2016 (right to buy) Common Stock (6,250) $42.22 Dec. 20, 2026 6,250 Acquired
June 14, 2017 PCRX Stock Option (Right to Buy) Common Stock (2,714) $44.20 June 14, 2027 2,714 Acquired
Dec. 20, 2016 ALNY Stock Option (right to buy) Common Stock (25,000) $42.22 Dec. 20, 2026 25,000 Acquired
Sept. 19, 2016 ALNY Stock Option (right to buy) Common Stock (125,000) $77.10 Sept. 18, 2026 125,000 Acquired
June 15, 2016 PCRX Stock Option (Right to Buy) Common Stock (2,975) $40.34 June 15, 2026 2,975 Acquired
June 3, 2015 PCRX Stock Option (Right to Buy) Common Stock (4,000) $79.43 June 3, 2025 4,000 Acquired
June 3, 2014 PCRX Stock Option (Right to Buy) Common Stock (8,000) $81.00 June 3, 2024 8,000 Acquired
March 4, 2014 PCRX Stock Option (Right to Buy) Common Stock (15,000) $80.43 March 3, 2024 15,000 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Holdings reported on Form 4 42 reported holdings

08

Positions listed on each Form 4 without a transaction in that filing (Table I and II holdings), newest filing first.

DateTickerSecuritySharesExercise priceExpirationOwnership
Sept. 22, 2026 ALNY Common Stock 407 · · Indirect
March 6, 2026 ALNY Common Stock 407 · · Indirect
March 4, 2026 ALNY Common Stock 407 · · Indirect
March 2, 2026 ALNY Common Stock 407 · · Indirect
Feb. 17, 2026 ALNY Common Stock 407 · · Indirect
Jan. 14, 2026 ALNY Common Stock 407 · · Indirect
Dec. 1, 2025 ALNY Common Stock 407 · · Indirect
Nov. 14, 2025 ALNY Common Stock 407 · · Indirect
Oct. 3, 2025 ALNY Common Stock 407 · · Indirect
Aug. 19, 2025 ALNY Common Stock 407 · · Indirect
June 3, 2025 ALNY Common Stock 407 · · Indirect
May 19, 2025 ALNY Common Stock 407 · · Indirect
May 6, 2025 ALNY Common Stock 407 · · Indirect
March 5, 2025 ALNY Common Stock 407 · · Indirect
March 3, 2025 ALNY Common Stock 407 · · Indirect
Feb. 18, 2025 ALNY Common Stock 407 · · Indirect
Nov. 27, 2024 ALNY Common Stock 407 · · Indirect
Aug. 22, 2024 ALNY Common Stock 407 · · Indirect
Aug. 2, 2024 ALNY Common Stock 407 · · Indirect
July 12, 2024 ALNY Common Stock 407 · · Indirect
June 26, 2024 ALNY Common Stock 407 · · Indirect
March 5, 2024 ALNY Common Stock 407 · · Indirect
Feb. 29, 2024 ALNY Common Stock 407 · · Indirect
Feb. 20, 2024 ALNY Common Stock 407 · · Indirect
Aug. 7, 2023 ALNY Common Stock 407 · · Indirect
April 28, 2023 ALNY Common Stock 407 · · Indirect
Aug. 5, 2022 ALNY Common Stock 407 · · Indirect
Dec. 23, 2021 ALNY Common Stock 407 · · Indirect
Aug. 9, 2021 ALNY Common Stock 407 · · Indirect
April 21, 2021 ALNY Common Stock 407 · · Indirect
Feb. 16, 2021 ALNY Common Stock 407 · · Indirect
Jan. 13, 2021 ALNY Common Stock 407 · · Indirect
July 14, 2020 ALNY Common Stock 407 · · Indirect
July 10, 2020 ALNY Common Stock 407 · · Indirect
May 7, 2020 ALNY Common Stock 407 · · Indirect
April 9, 2020 ALNY Common Stock 407 · · Indirect
Feb. 11, 2020 ALNY Common Stock 407 · · Indirect
Dec. 13, 2019 ALNY Common Stock 407 · · Indirect
Nov. 22, 2019 ALNY Common Stock 407 · · Indirect
Aug. 7, 2019 ALNY Common Stock 1,916 · · Direct
June 7, 2019 ALNY Common Stock 1,916 · · Direct
Sept. 4, 2018 ALNY Common Stock 308 · · Indirect

Compensation (DEF 14A)

10

Matched by name from proxy statements (DEF 14A) — verify against the filing.

ALNY

PEO
Fiscal yearSalaryBonusStock awards Option awardsNon-equity incentivePension changeOtherTotal
2025 $1,404,200 · · · $3,562,500 · $25,020 $14,867,600
2024 $1,253,400 · · · $2,975,400 · $24,770 $11,492,970
2023 $975,800 · · $3,369,000 $1,155,000 · $20,720 $8,895,670

Figures from the Summary Compensation Table of the company's proxy statement (DEF 14A). Compensation is not a recommendation.