MDGL Madrigal Pharmaceuticals, Inc. - Common Stock
MDGL Instantánea de la Acción Precio, capitalización bursátil, P/E, BPA, ROE, deuda/capital, rango de 52 semanas
MDGL Gráfico del Precio de la Acción OHLCV diario con indicadores técnicos — desplace, amplíe y personalice su vista
Rendimiento a 10 años Tendencias de ingresos, beneficio neto, márgenes y BPA
Valoración Ratios P/E, P/S, P/B, EV/EBITDA: ¿está la acción cara o barata?
Rentabilidad Márgenes brutos, operativos y netos; ROE, ROA, ROIC
Salud financiera Deuda, liquidez, solvencia — solidez del balance general
Crecimiento Crecimiento de ingresos, BPA y beneficio neto: interanual, CAGR a 3 años, CAGR a 5 años
Eficiencia de capital Rotación de activos, rotación de inventario, rotación de cuentas por cobrar
MDGL Consenso de analistas Opiniones de analistas alcistas y bajistas, precio objetivo a 12 meses, potencial alcista
- Compra fuerte 5 20,8%
- Compra 16 66,7%
- Mantener 3 12,5%
- Venta 0 0,0%
- Venta fuerte 0 0,0%
Precio objetivo a 12 meses
16 analistas · 2026-08-13Historial de Ganancias EPS real vs estimado, sorpresa %, tasa de aciertos, próxima fecha de resultados
| Período | EPS Actual | EPS est. | Sorpresa |
|---|---|---|---|
| 30 de junio de 2026 | $-1.99 | $-2.62 | 0.63% |
| 31 de marzo de 2026 | $-3.25 | $-4.11 | 0.86% |
| 31 de diciembre de 2025 | $-2.57 | $-0.69 | -1.9% |
| 30 de septiembre de 2025 | $-4.96 | $-2.12 | -2.8% |
| 30 de junio de 2025 | $-1.90 | $-3.71 | 1.8% |
| 31 de marzo de 2025 | $-3.32 | $-3.84 | 0.52% |
Comparación de pares (subindustria GICS) Métricas clave frente a competidores del sector
| Ticker | Capitalización Bursátil | P/E | Ingresos interanuales | Margen Neto | ROE | Margen Bruto |
|---|---|---|---|---|---|---|
| MDGL | $13.30B | -45.3 | 432.1% | -30.1% | -44.4% | — |
| NBIX | $14.20B | 30.4 | 21.4% | 16.7% | 16.1% | — |
| BBIO | $14.90B | -20.2 | 126.3% | -146.0% | 41.2% | — |
| BMRN | $11.43B | 33.0 | 12.9% | 10.8% | 5.8% | — |
| EXEL | $11.44B | 15.7 | 7.0% | 33.7% | 37.3% | — |
| ARWR | $4.68B | -3449.0 | 23258.2% | -0.20% | -0.50% | — |
| HALO | $7.93B | 26.3 | 37.5% | 22.7% | 166.1% | — |
| PRAX | $7.43B | -21.9 | 249.5% | — | -47.3% | — |
| CYTK | $7.81B | -9.7 | 376.6% | -891.6% | 152.7% | — |
| SMMT | $13.56B | -12.1 | — | — | -235.1% | — |
| APGE | $5.16B | -17.9 | — | — | — | — |
Fundamentales Completos Todas las métricas por año — estado de resultados, balance general, flujo de caja
Estado de resultados 15
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $958M | $180M | $0 | $0 | $0 | · | $0 | $0 | $0 | · | · | · | |
| Cost of Revenue | · | $6M | $0 | $0 | · | · | · | · | · | · | · | · | |
| SG&A Expense | $814M | $435M | $108M | $48M | $37M | $22M | $23M | $15M | $8M | $9M | $805.8K | $16M | |
| Operating Expenses | $1.26B | $678M | $380M | $294M | $242M | $207M | $95M | $41M | $32M | $25M | $3M | $84M | |
| Operating Income | $-300M | $-498M | $-380M | $-294M | $-242M | $-207M | $-95M | $-41M | $-32M | $-25M | $-3M | $-84M | |
| Interest Expense | · | · | $13M | $4M | $0 | $0 | · | · | · | $1M | $4M | · | |
| Interest Income | $37M | $47M | $20M | $2M | $363.0K | · | · | · | · | · | · | · | |
| Other Non-op | $-463.0K | $0 | $0 | · | · | · | · | · | · | · | · | · | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | · | · | · | · | |
| Net Income | $-288M | $-466M | $-374M | $-295M | $-242M | $-202M | $-84M | $-33M | $-31M | $-26M | · | · | |
| EPS (Basic) | $-10.15 | $-17.31 | $-17.33 | $-17.23 | $-14.63 | $-13.09 | · | · | · | · | · | · | |
| EPS (Diluted) | $-10.15 | $-17.31 | $-17.33 | $-17.23 | $-14.63 | $-13.09 | · | · | · | · | · | · | |
| Shares (Basic) | 28,409,706 | 26,908,070 | 21,562,581 | 17,137,201 | 16,535,188 | 15,446,638 | · | · | · | · | · | · | |
| Shares (Diluted) | 28,409,706 | 26,908,070 | 21,562,581 | 17,137,201 | 16,535,188 | 15,446,638 | · | · | · | · | · | · | |
| EBITDA | $-299M | $-497M | $-380M | $-293M | $-242M | $-206M | $-95M | · | $-32M | $-25M | · | $-83M |
Balance general 25
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $199M | $100M | $100M | $332M | $36M | $54M | $47M | $57M | $149M | $19M | $306.0K | $148.1K | |
| Short-term Investments | · | · | · | · | · | · | · | · | $43M | $21M | $32M | $52M | |
| Receivables | $134M | $54M | $0 | · | · | · | · | · | · | · | · | · | |
| Inventory | $75M | $34M | $0 | · | · | · | · | · | · | · | · | · | |
| Prepaid Expense | $48M | $14M | $3M | $3M | $1M | $1M | $1M | $1M | $485.0K | $707.0K | $50.0K | $2M | |
| Current Assets | $1.25B | $1.03B | $637M | $361M | $272M | $285M | $440M | $485M | $192M | $41M | $363.6K | $99M | |
| PP&E (Net) | $1M | $2M | $2M | $601.0K | $851.0K | $1M | $1M | $227.0K | $301.0K | $3.0K | $420.0K | $1M | |
| PP&E (Gross) | · | · | · | · | · | · | · | · | · | · | $22M | $22M | |
| Accum. Depreciation | · | · | · | · | · | · | · | · | · | · | $21M | $20M | |
| Intangibles | $7M | $5M | $0 | · | · | · | · | · | · | · | · | · | |
| Other Non-current Assets | $0 | · | · | · | · | · | · | · | · | · | · | $305.0K | |
| Total Assets | $1.26B | $1.04B | $641M | $363M | $273M | $287M | $442M | $485M | $192M | $41M | $363.6K | $101M | |
| Accounts Payable | $49M | $44M | $28M | $24M | $21M | $1M | $1M | $2M | $2M | $762.0K | $102.3K | $3M | |
| Accrued Liabilities | $260M | $125M | $90M | $91M | $55M | $45M | $24M | $6M | $8M | $4M | $70.2K | · | |
| Current Liabilities | $310M | $169M | $119M | $116M | $77M | $47M | $25M | $8M | $10M | $5M | $49M | $31M | |
| Capital Leases | $7M | $1M | $1M | $0 | $387.0K | $468.0K | $361.0K | · | · | · | · | $43.0K | |
| Total Liabilities | $657M | $288M | $235M | $165M | $77M | $47M | $25M | $8M | $10M | $5M | $49M | $36M | |
| Long-term Debt | $340M | $118M | $115M | $70M | · | · | · | · | · | · | · | · | |
| Total Debt | $340M | $118M | $115M | $49M | · | · | · | · | · | · | · | · | |
| Common Stock | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $1.0K | $1.0K | $18 | $11.0K | |
| Retained Earnings | $-2.09B | $-1.80B | $-1.34B | $-963M | $-667M | $-425M | $-223M | $-139M | $-106M | $-75M | $-49M | $-638M | |
| AOCI | $873.0K | $468.0K | $468.0K | $-32.0K | $-80.0K | $47.0K | $216.0K | $-319.0K | $-31.0K | $25.0K | $4.0K | $4.0K | |
| Stockholders' Equity | $603M | $754M | $405M | $197M | $196M | $240M | $417M | $477M | $182M | $36M | $-49M | $-42M | |
| Liabilities + Equity | $1.26B | $1.04B | $641M | $363M | $273M | $287M | $442M | $485M | $192M | $41M | $363.6K | $101M | |
| Shares Outstanding | 22,842,073 | 22,004,679 | 19,875,427 | 18,102,523 | 17,103,395 | 15,508,146 | 15,429,154 | 15,409,023 | 14,227,634 | 11,951,866 | 176,158 | 109,120,670 |
Flujo de Efectivo 11
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $2M | $1M | $527.0K | $467.0K | $405.0K | $471.0K | $112.0K | $96.0K | $77.0K | $156 | $662.0K | $673.0K | |
| Stock-based Comp | $98M | $80M | $50M | $32M | $27M | $21M | $23M | $13M | $3M | $8M | $4M | $7M | |
| Other Non-cash | $-905.0K | $-71M | $-862.0K | $38M | $31M | $23M | $19M | · | $6M | · | · | · | |
| Operating Cash Flow | $-190M | $-456M | $-324M | $-225M | $-184M | $-158M | $-42M | $-26M | $-22M | $-18M | $-3M | $-79M | |
| CapEx | $467.0K | $1M | $1M | $217.0K | $209.0K | $334.0K | $172.0K | $22.0K | $125.0K | $3.0K | $58.0K | $144.0K | |
| Investing Cash Flow | $32M | $-274M | $-503M | $207M | $-5M | $160M | $31M | $-380M | $-22M | $22M | · | · | |
| Stock Issued | · | · | · | · | · | · | · | · | · | $6M | $6 | $90M | |
| Net Stock Activity | · | · | · | · | · | · | · | · | · | $6M | · | $90M | |
| Financing Cash Flow | $256M | $735M | $595M | $313M | $171M | $5M | $235.0K | $314M | $174M | $14M | · | · | |
| Net Change in Cash | $99M | $5M | $-232M | $295M | $-18M | · | · | · | $129M | $19M | · | · | |
| Free Cash Flow | $-190M | $-457M | $-326M | $-225M | $-184M | $-158M | $-42M | · | $-22M | $-18M | · | $-79M |
Rentabilidad 5
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -31.3% | -276.4% | · | · | · | · | · | · | · | · | · | · | |
| Net Margin | -30.1% | -258.6% | · | · | · | · | · | · | · | · | · | · | |
| EBITDA Margin | -31.2% | -275.8% | · | · | · | · | · | · | · | · | · | · | |
| ROA | -25.1% | -55.4% | -74.5% | -92.9% | -86.3% | -55.5% | -18.1% | · | -26.7% | · | · | · | |
| ROE | -44.4% | -60.8% | -174.8% | -283.9% | -112.2% | -76.4% | -19.6% | · | -28.5% | · | · | · |
Liquidez y Solvencia 5
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 4.0 | 6.1 | 5.4 | 3.1 | 3.5 | 6.1 | 17.5 | · | 19.1 | 8.6 | · | 3.2 | |
| Quick Ratio | 1.1 | 0.9 | 0.8 | 2.9 | 0.5 | 1.2 | 1.9 | · | 19.0 | 8.4 | · | 3.2 | |
| Debt / Equity | 0.6 | 0.2 | 0.3 | 0.2 | · | · | · | · | · | · | · | · | |
| LT Debt / Equity | 0.6 | 0.2 | 0.3 | 0.2 | · | · | · | · | · | · | · | · | |
| Interest Coverage | · | · | -29.9 | -74.1 | · | · | · | · | · | -20.8 | · | · |
Eficiencia 3
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.8 | 0.2 | 0.0 | · | 0.0 | 0.0 | 0.0 | · | · | · | · | · | |
| Inventory Turnover | · | 0.4 | · | · | · | · | · | · | · | · | · | · | |
| Receivables Turnover | 10.2 | 6.7 | · | · | · | · | · | · | · | · | · | · |
Tasas de Crecimiento 1
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue YoY | 432.1% | · | · | · | · | · | · | · | · | · | · | · |
Valoración (TTM) 14
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $958M | $180M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | · | · | · | |
| Net Income TTM | $-288M | $-466M | $-374M | $-295M | $-242M | $-202M | $-84M | $-33M | $-31M | $-26M | · | · | |
| Market Cap | $13.30B | $6.79B | $4.60B | $5.25B | $1.45B | $1.72B | $1.41B | · | $1.31B | $178M | · | $10.12B | |
| Enterprise Value | $13.44B | $6.81B | $4.61B | $4.97B | · | · | · | · | · | · | · | · | |
| P/E | -45.3 | -14.1 | -11.6 | -16.8 | -5.8 | -8.5 | · | · | · | · | · | · | |
| P/S | 13.9 | 37.7 | · | · | · | · | · | · | · | · | · | · | |
| P/B | 22.1 | 9.0 | 11.3 | 26.6 | 7.4 | 7.2 | 3.4 | · | 7.2 | 4.9 | · | 155.4 | |
| P / Tangible Book | 22.3 | 9.1 | 11.3 | 26.6 | 7.4 | 7.2 | · | · | · | · | · | · | |
| P / Cash Flow | -70.2 | -14.9 | -14.2 | -23.4 | -7.9 | -10.9 | -33.8 | · | -58.5 | -10.1 | · | -128.2 | |
| P / FCF | -70.0 | -14.9 | -14.1 | -23.3 | -7.9 | -10.9 | -33.6 | · | -58.2 | -10.1 | · | -128.0 | |
| EV / EBITDA | -45.0 | -13.7 | -12.1 | -17.0 | · | · | · | · | · | · | · | · | |
| EV / FCF | -70.7 | -14.9 | -14.2 | -22.1 | · | · | · | · | · | · | · | · | |
| EV / Revenue | 14.0 | 37.8 | · | · | · | · | · | · | · | · | · | · | |
| Earnings Yield | -2.2% | -7.1% | -8.6% | -5.9% | -17.3% | -11.8% | · | · | · | · | · | · |
Estado de resultados 14
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $364M | $311M | $321M | $287M | $213M | $137M | $103M | $62M | $15M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | |
| Cost of Revenue | · | · | · | · | · | $5M | · | · | · | $0 | · | · | · | · | · | · | |
| SG&A Expense | $289M | $269M | $240M | $209M | $197M | $168M | $141M | $108M | $105M | $81M | $47M | $28M | $18M | $16M | $15M | $12M | |
| Operating Expenses | $421M | $404M | $381M | $401M | $260M | $217M | $170M | $178M | $177M | $152M | $117M | $99M | $86M | $78M | $85M | $80M | |
| Operating Income | $-56M | $-93M | $-60M | $-114M | $-47M | $-79M | $-67M | $-116M | $-163M | $-152M | $-117M | $-99M | $-86M | $-78M | $-85M | $-80M | |
| Interest Expense | · | · | · | · | · | $3M | · | $4M | $4M | $4M | $4M | $4M | $3M | $2M | $2M | $2M | |
| Interest Income | $7M | $8M | $9M | $10M | $8M | $9M | $11M | $13M | $14M | $8M | $9M | $3M | $4M | $4M | $1M | $717.0K | |
| Other Non-op | $-795.0K | $-2M | $-128.0K | $-293.0K | $-42.0K | $0 | $0 | $0 | $0 | · | · | · | · | · | · | · | |
| Net Income | $-58M | $-94M | $-59M | $-114M | $-42M | $-73M | $-59M | $-107M | $-152M | $-148M | $-112M | $-99M | $-86M | $-77M | $-86M | $-81M | |
| EPS (Basic) | $-1.99 | $-3.25 | $-2.55 | $-4.01 | $-1.50 | $-2.61 | $-2.50 | $-4.92 | $-7.10 | $-7.38 | $-5.73 | $-5.34 | $-4.69 | $-4.23 | $-4.98 | $-4.75 | |
| EPS (Diluted) | $-1.99 | $-3.25 | $-2.55 | $-4.01 | $-1.50 | $-2.61 | $-2.50 | $-4.92 | $-7.10 | $-7.38 | $-5.73 | $-5.34 | $-4.69 | $-4.23 | $-4.98 | $-4.75 | |
| Shares (Basic) | 29,145,271 | 29,032,422 | -44,346,523 | 28,508,089 | 28,232,604 | 28,085,234 | -41,877,182 | 21,745,929 | 21,402,646 | 20,001,569 | -36,287,516 | 18,476,414 | 18,310,952 | 18,187,924 | -34,172,984 | 17,103,395 | |
| Shares (Diluted) | 29,145,271 | 29,032,422 | -44,346,523 | 28,508,089 | 28,232,604 | 28,085,234 | -41,877,182 | 21,745,929 | 21,402,646 | 20,001,569 | -36,287,516 | 18,476,414 | 18,310,952 | 18,187,924 | -34,172,984 | 17,103,395 | |
| EBITDA | $-56M | $-92M | · | $-114M | $-47M | $-79M | · | $-116M | $-163M | $-152M | · | $-99M | $-86M | $-78M | · | $-80M |
Balance general 22
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $293M | $227M | $199M | $296M | $186M | $184M | $100M | $233M | $495M | $623M | · | $62M | $77M | $113M | · | $59M | |
| Receivables | $192M | $187M | $134M | $113M | $79M | $61M | $54M | $30M | $7M | · | · | · | · | · | · | · | |
| Inventory | $99M | $112M | $75M | $69M | $63M | $55M | $34M | $9M | $7M | $854.0K | · | · | · | · | · | · | |
| Prepaid Expense | $69M | $65M | $48M | $49M | $59M | $23M | $14M | $21M | $15M | $14M | · | $3M | $3M | $2M | · | $4M | |
| Current Assets | $1.20B | $1.18B | $1.25B | $1.35B | $1.00B | $988M | $1.03B | $1.06B | $1.09B | $1.07B | · | $235M | $302M | $331M | · | $157M | |
| PP&E (Net) | $12M | $8M | $1M | $3M | $2M | $2M | $2M | $2M | $2M | $2M | · | $659.0K | $455.0K | $512.0K | · | $701.0K | |
| Intangibles | $7M | $7M | $7M | $7M | $5M | $5M | $5M | $5M | $5M | $5M | · | · | · | · | · | · | |
| Other Non-current Assets | $21M | $23M | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Total Assets | $1.24B | $1.23B | $1.26B | $1.36B | $1.02B | $997M | $1.04B | $1.07B | $1.10B | $1.08B | · | $238M | $302M | $332M | · | $159M | |
| Accounts Payable | $35M | $61M | $49M | $45M | $38M | $42M | $44M | $46M | $9M | $22M | · | $17M | $18M | $12M | · | $19M | |
| Accrued Liabilities | $339M | $276M | $260M | $345M | $157M | $124M | $125M | $131M | $116M | $92M | · | $83M | $82M | $86M | · | $80M | |
| Current Liabilities | $374M | $338M | $310M | $391M | $197M | $167M | $169M | $178M | $125M | $114M | · | $100M | $100M | $98M | · | $99M | |
| Capital Leases | $6M | $5M | $7M | $6M | $5M | $750.0K | $1M | $1M | $900.0K | $1M | · | $1M | · | · | · | $71.0K | |
| Total Liabilities | $721M | $684M | $657M | $737M | $319M | $286M | $288M | $296M | $243M | $232M | · | $216M | $199M | $182M | · | $148M | |
| Long-term Debt | $341M | $340M | $340M | $340M | $118M | $118M | · | $117M | $117M | $116M | · | $149M | $132M | $114M | · | $68M | |
| Total Debt | $341M | $340M | · | $340M | $118M | $118M | · | $117M | $117M | $116M | · | $115M | $99M | $84M | · | $49M | |
| Common Stock | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | · | $2.0K | $2.0K | $2.0K | · | $2.0K | |
| Retained Earnings | $-2.24B | $-2.18B | $-2.09B | $-2.03B | $-1.92B | $-1.88B | $-1.80B | $-1.74B | $-1.64B | $-1.48B | · | $-1.22B | $-1.13B | $-1.04B | · | $-877M | |
| AOCI | $808.0K | $1M | $873.0K | $1M | $1M | $389.0K | $468.0K | $1M | $-368.0K | $-172.0K | · | $-42.0K | $-89.0K | $-86.0K | · | $-237.0K | |
| Stockholders' Equity | $524M | $543M | $603M | $626M | $696M | $711M | $754M | $777M | $857M | $851M | $405M | $22M | $104M | $150M | $197M | $11M | |
| Liabilities + Equity | $1.24B | $1.23B | $1.26B | $1.36B | $1.02B | $997M | $1.04B | $1.07B | $1.10B | $1.08B | · | $238M | $302M | $332M | · | $159M | |
| Shares Outstanding | 23,093,974 | 23,041,918 | 22,842,073 | 22,704,303 | 22,221,116 | 22,187,716 | 22,004,679 | 21,806,436 | 19,875,427 | 19,875,427 | 19,875,427 | 18,494,192 | 18,459,033 | 18,283,074 | 18,102,523 | 17,103,395 |
Flujo de Efectivo 9
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $381.0K | $386.0K | $392.0K | $358.0K | $377.0K | $379.0K | $363.0K | $298.0K | $267.0K | $168.0K | $142.0K | $135.0K | $126.0K | $124.0K | $129.0K | $121.0K | |
| Stock-based Comp | $35M | $34M | $26M | $26M | $25M | $21M | $18M | $18M | $24M | $20M | $15M | $13M | $11M | $11M | $8M | $8M | |
| Other Non-cash | · | $-107M | · | · | · | $-37M | · | · | · | $-22M | · | · | · | $-19M | · | · | |
| Operating Cash Flow | $23M | $-167M | $-133M | $80M | $-47M | $-89M | $-104M | $-67M | $-135M | $-149M | $-80M | $-85M | $-75M | $-84M | $-59M | $-59M | |
| CapEx | $4M | $4M | $-390.0K | $857.0K | $0 | $0 | $195.0K | $779.0K | $131.0K | $357.0K | $1M | $339.0K | $69.0K | $35.0K | $29.0K | $33.0K | |
| Investing Cash Flow | $34M | $192M | $28M | $-207M | $48M | $164M | $-48M | $-202M | $-122M | $98M | $-362M | $50M | $-4M | $-187M | $66M | $65M | |
| Financing Cash Flow | $3M | $2M | $9M | $237M | $2M | $9M | $20M | $7M | $134M | $574M | $480M | $20M | $43M | $53M | $264M | $0 | |
| Net Change in Cash | $61M | $28M | $-97M | $110M | $3M | $84M | $-133M | $-262M | $-123M | $523M | $38M | $-15M | $-36M | $-218M | · | · | |
| Free Cash Flow | · | $-171M | · | · | · | $-89M | · | · | · | $-150M | · | · | · | $-84M | · | · |
Rentabilidad 5
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -15.5% | -29.8% | · | -39.7% | -22.2% | -57.8% | · | · | · | · | · | · | · | · | · | · | |
| Net Margin | -15.9% | -30.3% | · | -39.8% | -19.9% | -53.4% | · | · | · | · | · | · | · | · | · | · | |
| EBITDA Margin | -15.5% | -29.7% | · | -39.7% | -22.2% | -57.5% | · | · | · | · | · | · | · | · | · | · | |
| ROA | -5.1% | -8.5% | · | -9.4% | -4.0% | -7.0% | · | -16.3% | -21.7% | -20.9% | · | -49.8% | -33.1% | -27.7% | · | -35.0% | |
| ROE | -9.5% | -15.0% | · | -16.3% | -5.4% | -9.4% | · | -26.8% | -31.6% | -29.5% | · | -599.9% | -91.7% | -52.0% | · | -66.1% |
Liquidez y Solvencia 5
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 3.2 | 3.5 | · | 3.4 | 5.1 | 5.9 | · | 6.0 | 8.7 | 9.4 | · | 2.4 | 3.0 | 3.4 | · | 1.6 | |
| Quick Ratio | 1.3 | 1.2 | · | 1.0 | 1.4 | 1.5 | · | 1.5 | 4.0 | 5.4 | · | 0.6 | 0.8 | 1.2 | · | 0.6 | |
| Debt / Equity | 0.7 | 0.6 | · | 0.5 | 0.2 | 0.2 | · | 0.2 | 0.1 | 0.1 | · | 5.2 | 1.0 | 0.6 | · | 4.6 | |
| LT Debt / Equity | 0.7 | 0.6 | · | 0.5 | 0.2 | 0.2 | · | 0.2 | 0.1 | 0.1 | · | 5.2 | 1.0 | 0.6 | · | 4.6 | |
| Interest Coverage | · | · | · | · | · | -24.1 | · | -31.6 | -44.5 | -39.6 | · | -28.1 | -29.8 | -33.5 | · | -53.5 |
Eficiencia 3
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.3 | 0.3 | · | 0.2 | 0.2 | 0.1 | · | · | · | 0.0 | · | · | · | · | · | · | |
| Inventory Turnover | · | · | · | · | · | 0.2 | · | · | · | · | · | · | · | · | · | · | |
| Receivables Turnover | 2.7 | 2.5 | · | 4.0 | 4.9 | 4.5 | · | · | · | · | · | · | · | · | · | · |
Valoración (TTM) 14
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $1.18B | $949M | · | $699M | $427M | $214M | · | $77M | $15M | $0 | · | $0 | $0 | $0 | · | · | |
| Net Income TTM | $-309M | $-324M | · | $-337M | $-374M | $-480M | · | $-519M | $-510M | $-444M | · | $-347M | $-330M | $-315M | · | $-274M | |
| Market Cap | $12.40B | $12.06B | · | $10.41B | $6.72B | $7.35B | · | $4.63B | $5.57B | $5.31B | · | $2.70B | $4.26B | $4.43B | · | $1.11B | |
| Enterprise Value | $12.45B | $12.18B | · | $10.46B | $6.66B | $7.28B | · | $4.51B | $5.19B | $4.80B | · | $2.75B | $4.29B | $4.40B | · | $1.10B | |
| P/E | -49.9 | -46.0 | · | -30.1 | -17.6 | -14.6 | · | -8.5 | -11.0 | -11.6 | · | -7.6 | -12.4 | -13.4 | · | -4.1 | |
| P/S | 10.5 | 12.7 | · | 14.9 | 15.8 | 34.3 | · | 60.2 | 380.4 | · | · | · | · | · | · | · | |
| P/B | 23.7 | 22.2 | · | 16.6 | 9.7 | 10.3 | · | 6.0 | 6.5 | 6.2 | · | 121.4 | 41.2 | 29.5 | · | 104.2 | |
| P / Tangible Book | 24.0 | 22.5 | · | 16.8 | 9.7 | 10.4 | · | 6.0 | 6.5 | 6.3 | · | 121.4 | 41.2 | 29.5 | · | 104.2 | |
| P / Cash Flow | · | -72.0 | · | · | · | -82.7 | · | · | · | -35.6 | · | · | · | -52.7 | · | · | |
| P / FCF | · | -70.4 | · | · | · | -82.7 | · | · | · | -35.5 | · | · | · | -52.7 | · | · | |
| EV / EBITDA | -221.1 | -131.9 | · | -91.8 | -141.0 | -92.3 | · | -38.8 | -31.9 | -31.6 | · | -27.9 | -49.6 | -56.3 | · | -13.7 | |
| EV / FCF | · | -71.1 | · | · | · | -81.9 | · | · | · | -32.1 | · | · | · | -52.3 | · | · | |
| EV / Revenue | 10.6 | 12.8 | · | 15.0 | 15.6 | 34.0 | · | 58.7 | 354.6 | · | · | · | · | · | · | · | |
| Earnings Yield | -2.0% | -2.2% | · | -3.3% | -5.7% | -6.9% | · | -11.8% | -9.1% | -8.6% | · | -13.2% | -8.1% | -7.5% | · | -24.7% |
Estados Financieros Estado de resultados, balance general, flujo de caja — anual, últimos 5 años
Estado de resultados
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Ingresos | $958M | $180M | $0 | $0 | $0 |
| Margen Operativo % | -31.3% | -276.4% | — | — | — |
| Beneficio neto | $-288M | $-466M | $-374M | $-295M | $-242M |
| EPS Diluido | $-10.15 | $-17.31 | $-17.33 | $-17.23 | $-14.63 |
Balance general
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Deuda / Patrimonio | 0.6 | 0.2 | 0.3 | 0.2 | — |
| Ratio corriente | 4.0 | 6.1 | 5.4 | 3.1 | 3.5 |
| Ratio Rápido | 1.1 | 0.9 | 0.8 | 2.9 | 0.5 |
Flujo de Efectivo
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Flujo de caja libre | $-190M | $-457M | $-326M | $-225M | $-184M |
Últimas noticias Noticias recientes que mencionan a esta empresa
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Propietarios institucionales (13F) 461 declarantes · $9.9B total · A fecha de 30 de junio de 2026
Instituciones que informan tener esta acción en su Formulario 13F trimestral de la SEC. Solo posiciones largas; un solo presentador puede aparecer dos veces para tramos de opciones separados. Las patas de put/call de compensación grandes suelen reflejar la creación de mercado o el inventario cubierto, no la convicción direccional.
| Nuevas posiciones | Posiciones cerradas | Aumentado | Disminuido | Cambio neto de acciones |
|---|---|---|---|---|
| 86 (+22 vs trimestre anterior) | 38 (-26 vs trimestre anterior) | 149 (+17 vs trimestre anterior) | 124 (-10 vs trimestre anterior) | +2.4M |
Comparado con Q1 2026. Las presentaciones del Formulario 13F de la SEC vencen dentro de los 45 días posteriores al final del trimestre, más un pequeño margen para los presentadores tardíos; los trimestres que aún se encuentran dentro de esa ventana se omiten en favor del par más reciente completamente reportado.
| Institución | Valor | Acciones | % de 13F rastreadas | Tipo |
|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | $1 150 754 190 | 2 143 131 | 11,58% | Acciones |
| RTW INVESTMENTS, LP | $1 070 510 235 | 1 993 687 | 10,77% | Acciones |
| Avoro Capital Advisors LLC | $984 408 154 | 1 833 333 | 9,90% | Acciones |
| PAULSON & CO. INC. | $719 523 739 | 1 340 020 | 7,24% | Acciones |
| VANGUARD CAPITAL MANAGEMENT LLC | $448 711 933 | 835 668 | 4,51% | Acciones |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $419 750 461 | 781 731 | 4,22% | Acciones |
| WELLINGTON MANAGEMENT GROUP LLP | $412 459 753 | 768 153 | 4,15% | Acciones |
| STATE STREET CORP | $282 995 975 | 527 057 | 2,85% | Acciones |
| CITADEL ADVISORS LLC | $212 854 497 | 396 414 | 2,14% | Acciones |
| GEODE CAPITAL MANAGEMENT, LLC | $175 309 472 | 326 397 | 1,76% | Acciones |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $174 037 845 | 324 123 | 1,75% | Acciones |
| FMR LLC | $173 569 624 | 323 251 | 1,75% | Acciones |
| Polar Capital Holdings Plc | $131 162 924 | 244 274 | 1,32% | Acciones |
| NORGES BANK | $114 846 088 | 213 886 | 1,16% | Acciones |
| Artisan Partners Limited Partnership | $112 869 575 | 210 205 | 1,14% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $112 652 110 | 209 800 | 1,13% | Opción de compra |
| AMERIPRISE FINANCIAL INC | $110 097 782 | 205 040 | 1,11% | Acciones |
| Pictet Asset Management Holding SA | $103 486 147 | 192 896 | 1,04% | Acciones |
| ALLIANCEBERNSTEIN L.P. | $99 175 579 | 189 458 | 1,00% | Acciones |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $98 966 865 | 184 313 | 1,00% | Acciones |
| TORONTO DOMINION BANK | $97 419 912 | 181 432 | 0,98% | Acciones |
| Rock Springs Capital Management LP | $93 965 713 | 174 999 | 0,95% | Acciones |
| Hood River Capital Management LLC | $90 789 654 | 169 084 | 0,91% | Acciones |
| Holocene Advisors, LP | $82 112 542 | 152 924 | 0,83% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $79 796 140 | 148 610 | 0,80% | Acciones |
| Point72 Asset Management, L.P. | $73 577 722 | 137 029 | 0,74% | Acciones |
| Woodline Partners LP | $67 601 468 | 125 899 | 0,68% | Acciones |
| Assenagon Asset Management S.A. | $66 696 707 | 124 214 | 0,67% | Acciones |
| VANGUARD FIDUCIARY TRUST CO | $65 283 992 | 121 583 | 0,66% | Acciones |
| GOLDMAN SACHS GROUP INC | $65 240 499 | 121 502 | 0,66% | Acciones |
| Caption Management, LLC | $63 091 625 | 117 500 | 0,63% | Opción de compra |
| Clearbridge Investments, LLC | $58 701 796 | 109 325 | 0,59% | Acciones |
| Erste Asset Management GmbH | $58 111 529 | 110 210 | 0,58% | Acciones |
| D. E. Shaw & Co., Inc. | $57 829 515 | 107 700 | 0,58% | Opción de compra |
| JANE STREET GROUP, LLC | $55 950 190 | 104 200 | 0,56% | Opción de compra |
| ARMISTICE CAPITAL, LLC | $53 695 000 | 100 000 | 0,54% | Acciones |
| AMERICAN CENTURY COMPANIES INC | $53 371 576 | 99 396 | 0,54% | Acciones |
| NEW YORK STATE COMMON RETIREMENT FUND | $50 872 254 | 94 743 | 0,51% | Acciones |
| CITADEL ADVISORS LLC | $50 473 300 | 94 000 | 0,51% | Opción de venta |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $50 436 250 | 93 931 | 0,51% | Acciones |
| 683 Capital Management, LLC | $48 325 500 | 90 000 | 0,49% | Opción de venta |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $47 520 075 | 88 500 | 0,48% | Opción de venta |
| CITADEL ADVISORS LLC | $46 660 955 | 86 900 | 0,47% | Opción de compra |
| JANE STREET GROUP, LLC | $45 434 561 | 84 616 | 0,46% | Acciones |
| MILLENNIUM MANAGEMENT LLC | $43 598 192 | 81 196 | 0,44% | Acciones |
| Balyasny Asset Management L.P. | $42 392 203 | 78 950 | 0,43% | Acciones |
| Driehaus Capital Management LLC | $41 932 573 | 78 094 | 0,42% | Acciones |
| Candriam S.C.A. | $38 688 112 | 72 121 | 0,39% | Acciones |
| Tri Locum Partners LP | $36 659 187 | 68 273 | 0,37% | Acciones |
| Caption Management, LLC | $35 277 615 | 65 700 | 0,35% | Opción de venta |
| Vestal Point Capital, LP | $34 901 750 | 65 000 | 0,35% | Acciones |
| JANE STREET GROUP, LLC | $31 733 745 | 59 100 | 0,32% | Opción de venta |
| BNP PARIBAS FINANCIAL MARKETS | $31 142 026 | 57 998 | 0,31% | Acciones |
| UBS Group AG | $28 840 658 | 53 712 | 0,29% | Acciones |
| Jones Hill Capital LP | $28 214 038 | 52 545 | 0,28% | Acciones |
| EULAV Asset Management | $27 921 400 | 52 000 | 0,28% | Acciones |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $27 164 938 | 51 519 | 0,27% | Acciones |
| RENAISSANCE TECHNOLOGIES LLC | $24 668 557 | 45 942 | 0,25% | Acciones |
| Affinity Asset Advisors, LLC | $21 478 000 | 40 000 | 0,22% | Acciones |
| BANK OF AMERICA CORP /DE/ | $19 392 486 | 36 116 | 0,20% | Acciones |
| MILLENNIUM MANAGEMENT LLC | $19 330 200 | 36 000 | 0,19% | Opción de compra |
| SEGALL BRYANT & HAMILL, LLC | $17 420 806 | 32 444 | 0,18% | Acciones |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $17 056 217 | 31 765 | 0,17% | Acciones |
| Mirae Asset Global Investments Co., Ltd. | $16 784 520 | 31 259 | 0,17% | Acciones |
| BlackRock, Inc. | $16 705 588 | 31 112 | 0,17% | Acciones |
| GROUPAMA ASSET MANAGMENT | $16 611 546 | 30 941 | 0,17% | Acciones |
| Swiss National Bank | $16 076 283 | 29 940 | 0,16% | Acciones |
| PFM Health Sciences, LP | $15 739 615 | 29 313 | 0,16% | Acciones |
| CANADA PENSION PLAN INVESTMENT BOARD | $15 614 506 | 29 080 | 0,16% | Acciones |
| GILDER GAGNON HOWE & CO LLC | $15 342 272 | 28 573 | 0,15% | Acciones |
| Integral Health Asset Management, LLC | $13 423 750 | 25 000 | 0,14% | Acciones |
| California Public Employees Retirement System | $13 035 535 | 24 277 | 0,13% | Acciones |
| WCM INVESTMENT MANAGEMENT, LLC | $12 119 531 | 22 985 | 0,12% | Acciones |
| Susquehanna Portfolio Strategies, LLC | $11 814 511 | 22 003 | 0,12% | Acciones |
| D. E. Shaw & Co., Inc. | $11 803 772 | 21 983 | 0,12% | Acciones |
| Tao Capital Management LP | $11 275 950 | 21 000 | 0,11% | Acciones |
| HSBC HOLDINGS PLC | $10 831 355 | 20 172 | 0,11% | Acciones |
| FIRST TRUST ADVISORS LP | $10 645 570 | 19 826 | 0,11% | Acciones |
| D. E. Shaw & Co., Inc. | $10 470 525 | 19 500 | 0,11% | Opción de venta |
| Weiss Asset Management LP | $10 376 559 | 19 325 | 0,10% | Acciones |
| ArrowMark Colorado Holdings LLC | $10 000 157 | 18 624 | 0,10% | Acciones |
| RHUMBLINE ADVISERS | $9 747 742 | 18 154 | 0,10% | Acciones |
| CITIGROUP INC | $9 665 100 | 18 000 | 0,10% | Opción de compra |
| CITIGROUP INC | $9 665 100 | 18 000 | 0,10% | Opción de venta |
| SPHERA FUNDS MANAGEMENT LTD. | $9 353 132 | 17 419 | 0,09% | Acciones |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $8 923 593 | 17 047 | 0,09% | Acciones |
| WOLVERINE TRADING, LLC | $8 507 520 | 19 200 | 0,09% | Opción de compra |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $8 405 952 | 15 655 | 0,08% | Acciones |
| Cubist Systematic Strategies, LLC | $8 204 782 | 17 889 | 0,08% | Acciones |
| VANGUARD ASSET MANAGEMENT, Ltd | $8 163 788 | 15 204 | 0,08% | Acciones |
| JANUS HENDERSON GROUP PLC | $8 049 398 | 15 377 | 0,08% | Acciones |
| RAYMOND JAMES FINANCIAL INC | $7 976 929 | 14 856 | 0,08% | Acciones |
| Cutter Capital Management, LP | $7 949 520 | 24 000 | 0,08% | Acciones |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $7 658 518 | 14 263 | 0,08% | Acciones |
| ENVESTNET ASSET MANAGEMENT INC | $7 658 427 | 14 263 | 0,08% | Acciones |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $7 515 689 | 13 997 | 0,08% | Acciones |
| Catalyst Funds Management Pty Ltd | $7 281 579 | 13 561 | 0,07% | Acciones |
| ALKEON CAPITAL MANAGEMENT LLC | $7 048 006 | 13 126 | 0,07% | Acciones |
| AXA Investment Managers S.A. | $6 896 412 | 15 036 | 0,07% | Acciones |
| JOURNEY STRATEGIC WEALTH LLC | $6 710 885 | 12 820 | 0,07% | Acciones |
Informantes de la empresa 46 insiders · 25 directivos · 22 consejeros
| Insider | Rol | Última actividad | Acciones en propiedad | Compras 12m | Ventas 12m | Neto 12m |
|---|---|---|---|---|---|---|
| William John Sibold | President and CEO | 17 de julio de 2026 M | 209 329 | 0 | 10 | $-1 368 254 |
| Chen Schor | Former President and CEO | 22 de julio de 2016 F | 37 178 | 0 | 0 | $0 |
| Anne Clem Whitaker | President and CEO | 2 de marzo de 2015 A | 500 000 | 0 | 0 | $0 |
| Safi R Bahcall | President and CEO | 13 de noviembre de 2013 P | 2 053 135 | 0 | 0 | $0 |
| Alex G. Howarth | Chief Financial Officer | 23 de enero de 2024 A | 18 737 | 0 | 0 | $0 |
| Marc R Schneebaum | Chief Financial Officer | 22 de febrero de 2021 A | 41 668 | 0 | 0 | $0 |
| Keith S Ehrlich | VP, Fin. and Admin., CFO | 3 de marzo de 2014 A | 17 573 | 0 | 0 | $0 |
| Sumant Ramachandra | President, R&D | 11 de marzo de 2013 A | 75 000 | 0 | 0 | $0 |
| David Soergel | Chief Medical Officer | 1 de junio de 2026 S | 10 033 | 0 | 1 | $-516 561 |
| Carole Huntsman | Chief Commercial Officer | 21 de noviembre de 2024 S | 10 785 | 0 | 0 | $0 |
| Shannon T Kelley | General Counsel | 15 de agosto de 2024 A | 7 982 | 0 | 0 | $0 |
| Robert E. Waltermire | Senior VP, Chief Pharma Dev. | 14 de junio de 2024 M | 5 500 | 0 | 0 | $0 |
| Brian Joseph Lynch | SVP and General Counsel | 23 de enero de 2024 A | 17 691 | 0 | 0 | $0 |
| Remy Sukhija | Chief Commercial Officer | 16 de enero de 2023 A | 15 001 | 0 | 0 | $0 |
| Wendy E Rieder | Former SVP, Gen. Counsel | 22 de julio de 2016 F | 17 730 | 0 | 0 | $0 |
| Vojo Vukovic | SVP, Chief Medical Officer | 2 de octubre de 2015 A | 35 249 | 0 | 0 | $0 |
| Arthur Mcmahon | SVP, Human Resources | 2 de marzo de 2015 A | — | 0 | 0 | $0 |
| Steven B Bernitz | SVP, Corporate Development | 18 de diciembre de 2013 A | 25 000 | 0 | 0 | $0 |
| Amar Singh | Sr. VP, Chief Business Officer | 5 de marzo de 2013 A | 21 031 | 0 | 0 | $0 |
| Keizo Koya | Sr. VP, Drug Development | 6 de marzo de 2012 A | 12 999 | 0 | 0 | $0 |
| BAILEY MICHAEL P | Sr. VP, Chief Comm. Officer | 5 de agosto de 2010 S | 29 627 | 0 | 0 | $0 |
| Jeremy G Chadwick | Sr. VP, Pgm Mgmt and Clin Ops | 1 de marzo de 2010 A | 23 761 | 0 | 0 | $0 |
| Eric W Jacobson | Sr. VP, Research and CMO | 13 de abril de 2009 A | 25 300 | 0 | 0 | $0 |
| James G Barsoum | Sr. VP, Research | 13 de abril de 2009 A | — | 0 | 0 | $0 |
| Martin D Williams | Sr. VP, Business Dev., CBO | 27 de febrero de 2008 A | 200 | 0 | 0 | $0 |
| REED JOHN C | Consejero | 15 de agosto de 2026 A | 647 | 0 | 0 | $0 |
| Daniel J. Brennan | Consejero | 17 de junio de 2026 A | 1 371 | 0 | 0 | $0 |
| James M Daly | Consejero | 17 de junio de 2026 A | 3 081 | 0 | 0 | $0 |
| Richard S Levy | Consejero | 17 de junio de 2026 A | 22 469 | 0 | 0 | $0 |
| Rebecca Taub, M.D. | Consejero | 17 de junio de 2026 A | 452 667 | 0 | 0 | $0 |
| Jacqualyn A Fouse | Consejero | 17 de junio de 2026 A | 1 551 | 0 | 0 | $0 |
| Kenneth Bate | Consejero | 15 de agosto de 2025 M | 2 627 | 0 | 0 | $0 |
| Fred B Craves | Consejero | 13 de septiembre de 2024 G | 360 076 | 0 | 0 | $0 |
| Baker Bros. Advisors LP | Consejero | 21 de marzo de 2024 P | — | 0 | 0 | $0 |
| Keith R Gollust | Consejero | 16 de junio de 2022 A | 1 539 169 | 0 | 0 | $0 |
| David V Milligan | Consejero | 16 de junio de 2022 A | 20 000 | 0 | 0 | $0 |
| BAY CITY CAPITAL LLC | Consejero | 11 de junio de 2018 S | 113 472 | 0 | 0 | $0 |
| Scott D Morenstein | Consejero | 1 de enero de 2016 A | 17 857 | 0 | 0 | $0 |
| Donald W Kufe | Consejero | 1 de julio de 2015 A | 25 748 | 0 | 0 | $0 |
| William S Reardon | Consejero | 1 de julio de 2015 A | 49 392 | 0 | 0 | $0 |
| Robert N Wilson | Consejero | 1 de julio de 2015 A | 760 936 | 0 | 0 | $0 |
| Lan Bo Chen | Consejero | 6 de agosto de 2009 P | 620 035 | 0 | 0 | $0 |
| Judah Folkman | Consejero | 30 de junio de 2007 A | 7 676 | 0 | 0 | $0 |
| Lin Huey Chen | Propietario del 10% | 6 de agosto de 2009 P | 620 035 | 0 | 0 | $0 |
| Paul A Friedman, M.D. | — | 13 de agosto de 2025 M | 187 164 | 0 | 0 | $0 |
| Bruce Kovner | — | 8 de diciembre de 2015 S | 340 970 | 0 | 0 | $0 |
Informantes de las presentaciones SEC Form 3/4/5; neto = solo P/S de mercado abierto
Activistas y propietarios del %+ 5 10 tenencias
Inversores que presentaron el Anexo 13D de la SEC — propiedad beneficiosa superior al % 5 con la intención de influir en el emisor (participaciones activistas, campañas de la junta directiva, M&A). Cada fila muestra el estado conocido más reciente de la posición de ese declarante.
| Declarante | Presentado | Participación | Estado | Propósito | Presentación |
|---|---|---|---|---|---|
| Rebecca Taub, M.D. ×2 presentaciones | 12 de diciembre de 2025 | 7,80% | Enmienda | — | SEC |
| Paul A Friedman, M.D. | 12 de diciembre de 2025 | 7,80% | Enmienda | — | SEC |
| Baker Bros. Advisors LP, Baker Bros. Advisors (GP) LLC, Julian C. Baker, Felix J. Baker ×5 presentaciones | 25 de marzo de 2024 | — | Presentación inicial | Estructura de capital | SEC |
| Fred B. Craves, Bay City Capital LLC, Bay City Capital Management IV LLC, Bay City Capital Fund IV, L.P. ×4 presentaciones | 13 de diciembre de 2023 | — | Presentación inicial | — | SEC |
| Bay City Capital LLC, Bay City Capital Management IV LLC, Bay City Capital Fund IV, L.P., Bay City Capital Fund IV Co-Investment Fund, L.P. ×2 presentaciones | 13 de diciembre de 2019 | — | Presentación inicial | — | SEC |
| Paul A. Friedman, M.D. | 17 de octubre de 2019 | — | Presentación inicial | Inversión pasiva | SEC |
| Caxton Corporation, Kovner 2012 Family Trust B, Kovner 2015-A Investment Trust, OB Select Opportunities, LLC, KFO HOLDINGS LLC, Kovner, Bruce ×6 presentaciones | 1 de agosto de 2016 | — | Presentación inicial | Inversión pasiva | SEC |
| Madrigal Pharmaceuticals, Inc. | 28 de abril de 2016 | — | Presentación inicial | M&A / venta | SEC |
| CxSynta LLC, Caxton Corporation, Kovner 2012 Family Trust B, Kovner 2015-A Investment Trust, OB Select Opportunities, LLC, Ben-Ur, David, Shteinbuk, Yuriy, Weisberg, Heath, KFO HOLDINGS LLC, Kovner, Bruce ×19 presentaciones | 23 de noviembre de 2015 | — | Presentación inicial | Campaña de la junta directiva | SEC |
| Keith R. Gollust ×2 presentaciones | 15 de enero de 2010 | — | Presentación inicial | Inversión pasiva | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Propiedad de ETFs Mantenido por 71 ETFs
El peso refleja solo las tenencias directas de acciones (N-PORT); los fondos apalancados o basados en derivados pueden tener exposición adicional a swaps no mostrada.
| Fondo | Ponderación | Unidades | A fecha de | Fuente |
|---|---|---|---|---|
| JXX · Janus Detroit Street Trust | 4,21% | 2 950 NS | 30 de abril de 2026 | N-PORT |
| HRTS · Tema ETF Trust | 1,46% | 1 519 NS | 31 de mayo de 2026 | N-PORT |
| BBP · ETFis Series Trust I | 1,44% | 1 655 NS | 30 de abril de 2026 | N-PORT |
| GURU · Global X Funds | 1,15% | 1 300 NS | 30 de abril de 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 1,12% | 11 249 NS | 30 de abril de 2026 | N-PORT |
| ILDR · First Trust Exchange-Traded Fund VI… | 1,10% | 6 360 NS | 31 de mayo de 2026 | N-PORT |
| GDOC · Goldman Sachs ETF Trust | 1,06% | 430 NS | 31 de mayo de 2026 | N-PORT |
| MEDI · Harbor ETF Trust | 0,90% | 477 NS | 30 de abril de 2026 | N-PORT |
| IBB · iShares Trust | 0,85% | 159 307 SH | 8 de agosto de 2026 | Diario |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,80% | 1 253 SH | 8 de agosto de 2026 | Diario |
| BIB · ProShares Trust | 0,57% | 847 NS | 31 de mayo de 2026 | N-PORT |
| QQQJ · Invesco Exchange-Traded Fund Trust … | 0,57% | 13 141 SH | 8 de agosto de 2026 | Diario |
| FNY · First Trust Exchange-Traded AlphaDE… | 0,52% | 5 239 NS | 30 de abril de 2026 | N-PORT |
| MMSC · First Trust Exchange-Traded Fund VI… | 0,42% | 440 NS | 31 de mayo de 2026 | N-PORT |
| ESSC · Strategy Shares | 0,36% | 178 NS | 30 de abril de 2026 | N-PORT |
| IQSM · New York Life Investments ETF Trust | 0,35% | 2 130 NS | 30 de abril de 2026 | N-PORT |
| ISCG · iShares Trust | 0,31% | 6 018 SH | 8 de agosto de 2026 | Diario |
| VBK · VANGUARD INDEX FUNDS | 0,27% | 244 326 SH | 8 de agosto de 2026 | Diario |
| RSSL · Global X Funds | 0,27% | 7 379 NS | 30 de abril de 2026 | N-PORT |
| IWP · iShares Trust | 0,26% | 103 367 SH | 8 de agosto de 2026 | Diario |
| ANEW · ProShares Trust | 0,25% | 39 NS | 31 de mayo de 2026 | N-PORT |
| BKMC · BNY Mellon ETF Trust | 0,22% | 2 668 NS | 30 de abril de 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,22% | 3 320 NS | 31 de mayo de 2026 | N-PORT |
| ITWO · ProShares Trust | 0,21% | 806 NS | 31 de mayo de 2026 | N-PORT |
| FSMD · FIDELITY COVINGTON TRUST | 0,21% | 9 660 NS | 30 de abril de 2026 | N-PORT |
| FNX · First Trust Exchange-Traded AlphaDE… | 0,20% | 5 201 NS | 30 de abril de 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,20% | 89 487 NS | 31 de mayo de 2026 | N-PORT |
| BBMC · J.P. Morgan Exchange-Traded Fund Tr… | 0,19% | 7 425 NS | 30 de abril de 2026 | N-PORT |
| FSCC · Federated Hermes ETF Trust | 0,18% | 997 NS | 31 de mayo de 2026 | N-PORT |
| SMLF · iShares Trust | 0,17% | 14 476 SH | 8 de agosto de 2026 | Diario |
| SCHM · SCHWAB STRATEGIC TRUST | 0,17% | 50 311 NS | 31 de mayo de 2026 | N-PORT |
| FAD · First Trust Exchange-Traded AlphaDE… | 0,16% | 1 441 NS | 30 de abril de 2026 | N-PORT |
| ISCB · iShares Trust | 0,15% | 856 SH | 8 de agosto de 2026 | Diario |
| IYH · iShares Trust | 0,15% | 10 700 SH | 8 de agosto de 2026 | Diario |
| VFMO · VANGUARD WELLINGTON FUND | 0,13% | 4 690 SH | 8 de agosto de 2026 | Diario |
| UWM · ProShares Trust | 0,13% | 630 NS | 31 de mayo de 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0,12% | 6 819 NS | 30 de abril de 2026 | N-PORT |
| SMMD · iShares Trust | 0,12% | 8 934 SH | 8 de agosto de 2026 | Diario |
| VB · VANGUARD INDEX FUNDS | 0,12% | 423 043 SH | 8 de agosto de 2026 | Diario |
| VHT · VANGUARD WORLD FUND | 0,12% | 44 809 SH | 8 de agosto de 2026 | Diario |
| VXF · VANGUARD INDEX FUNDS | 0,11% | 216 968 SH | 8 de agosto de 2026 | Diario |
| GSSC · Goldman Sachs ETF Trust | 0,10% | 2 022 NS | 31 de mayo de 2026 | N-PORT |
| ESML · iShares Trust | 0,10% | 5 759 SH | 8 de agosto de 2026 | Diario |
| ESUM · Strategy Shares | 0,10% | 296 NS | 30 de abril de 2026 | N-PORT |
| URTY · ProShares Trust | 0,09% | 635 NS | 31 de mayo de 2026 | N-PORT |
| EQAL · Invesco Exchange-Traded Fund Trust … | 0,09% | 1 478 SH | 8 de agosto de 2026 | Diario |
| SMMV · iShares Trust | 0,09% | 490 SH | 8 de agosto de 2026 | Diario |
| AVIE · AMERICAN CENTURY ETF TRUST | 0,08% | 16 NS | 31 de mayo de 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0,07% | 4 172 SH | 8 de agosto de 2026 | Diario |
| WSML · iShares Trust | 0,07% | 938 SH | 8 de agosto de 2026 | Diario |