SEPN Septerna, Inc. - Common Stock
$39,86
Precio · Ago 24, 2026
Fundamentales a fecha de Ago 10, 2026
Rango 52S
$12–$51
71% of range
Calificación del Analista
BUY
16 analysts
Precio Objetivo
$54
+36% upside
P/E (TTM)
-36.2
ROE
-12.9%
Margen de Beneficio Neto
-106.4%
SEPN Instantánea de la Acción Precio, capitalización bursátil, P/E, BPA, ROE, deuda/capital, rango de 52 semanas
Precio
$39.85
Capitalización Bursátil
$1.79B
P/E (TTM)
-36.2
BPA (TTM)
$-1.10
Ingresos (TTM)
$46M
Rendimiento div.
—
ROE
-12.9%
Deuda/Capital
—
Rango 52S
$12 – $51
SEPN Gráfico del Precio de la Acción OHLCV diario con indicadores técnicos — desplace, amplíe y personalice su vista
Configure
Rendimiento a 10 años Tendencias de ingresos, beneficio neto, márgenes y BPA
Ingresos y Beneficio Neto
$46M
2023-12-31
→
2025-12-31
BPA
$-1.10
2023-12-31
→
2025-12-31
Flujo de caja libre
$110M
2024-12-31
→
2025-12-31
Márgenes
-106.4%
Valoración Ratios P/E, P/S, P/B, EV/EBITDA: ¿está la acción cara o barata?
Métrica
Tendencia a 5 años
SEPN
Mediana de Pares
P/E (TTM)
-36.2
19.1
P/S (TTM) (P/V (TTM))
38.9
14.2
P/B (P/C)
4.7
3.6
Price / FCF (Precio / FCF)
16.3
—
Rentabilidad Márgenes brutos, operativos y netos; ROE, ROA, ROIC
Métrica
Tendencia a 5 años
SEPN
Mediana de Pares
Operating Margin (Margen Operativo)
-148.6%
—
Net Profit Margin (Margen de Beneficio Neto)
-106.4%
-4.3%
ROA
-9.3%
-2.9%
ROE
-12.9%
-6.8%
ROIC
-17.9%
—
Salud financiera Deuda, liquidez, solvencia — solidez del balance general
Métrica
Tendencia a 5 años
SEPN
Mediana de Pares
Current Ratio (Ratio corriente)
4.7
4.7
Quick Ratio (Ratio Rápido)
4.6
—
Crecimiento Crecimiento de ingresos, BPA y beneficio neto: interanual, CAGR a 3 años, CAGR a 5 años
Métrica
Tendencia a 5 años
SEPN
Mediana de Pares
Revenue YoY (Ingresos interanuales)
4174.5%
—
Eficiencia de capital Rotación de activos, rotación de inventario, rotación de cuentas por cobrar
Métrica
Tendencia a 5 años
SEPN
Mediana de Pares
SEPN Consenso de analistas Opiniones de analistas alcistas y bajistas, precio objetivo a 12 meses, potencial alcista
COMPRA
16 analistas
- Compra fuerte 5 31,2%
- Compra 10 62,5%
- Mantener 1 6,2%
- Venta 0 0,0%
- Venta fuerte 0 0,0%
Precio objetivo a 12 meses
9 analistas · 2026-08-24
Mediana
$51.00
Media
$54.22
← Por Debajo de Todos los Objetivos
$39.85
Mín
$48.00
Máx
$62.00
Objetivo mediano
$51.00
+28,0%
Objetivo medio
$54.22
+36,0%
Historial de Ganancias EPS real vs estimado, sorpresa %, tasa de aciertos, próxima fecha de resultados
Sorpresa Media
-0.33%
| Período | EPS Actual | EPS est. | Sorpresa |
|---|---|---|---|
| 30 de junio de 2026 | $-0.29 | $-0.43 | 0.14% |
| 31 de marzo de 2026 | $-0.19 | $-0.42 | 0.23% |
| 31 de diciembre de 2025 | $-0.24 | $-0.26 | 0.02% |
| 30 de septiembre de 2025 | $-0.09 | $0.81 | -0.90% |
| 30 de junio de 2025 | $-0.56 | $0.88 | -1.4% |
| 31 de marzo de 2025 | $-0.49 | $-0.46 | -0.03% |
Comparación de pares (subindustria GICS) Métricas clave frente a competidores del sector
| Ticker | Capitalización Bursátil | P/E | Ingresos interanuales | Margen Neto | ROE | Margen Bruto |
|---|---|---|---|---|---|---|
| SEPN | $1.25B | -25.3 | 4174.5% | -106.4% | -12.9% | — |
| RAPP | $1.45B | -10.6 | — | — | -29.8% | — |
| HRMY | $2.16B | 13.8 | 21.5% | 18.3% | 19.3% | 77.2% |
| TRLV | — | — | -0.45% | -10.3% | -10.4% | 60.2% |
| KARD | — | — | — | — | — | — |
| ETON | $457M | — | 104.9% | -5.8% | -18.4% | 53.5% |
| ANIP | $1.78B | 23.8 | 43.8% | 8.9% | 16.6% | — |
| AVLN | — | — | — | — | — | — |
| MAZE | $2.04B | -13.6 | — | — | -598.9% | — |
| HROW | $1.82B | -350.0 | 36.4% | -1.9% | -8.4% | 75.0% |
Fundamentales Completos Todas las métricas por año — estado de resultados, balance general, flujo de caja
Estado de resultados 15
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue | $46M | $1M | $151.0K | |
| R&D Expense | $98M | $65M | $36M | |
| SG&A Expense | $29M | $17M | $10M | |
| Operating Expenses | $114M | $82M | $-2M | |
| Operating Income | $-68M | $-81M | $2M | |
| Interest Income | $20M | $9M | $3M | |
| Other Non-op | $-100.0K | $-90.0K | $10.0K | |
| Pretax Income | $-49M | $-72M | $-49M | |
| Income Tax | $12.0K | $-498.0K | $691.0K | |
| Net Income | $-49M | $-72M | $4M | |
| EPS (Basic) | $-1.10 | $-7.26 | $0.29 | |
| EPS (Diluted) | $-1.10 | $-7.26 | $0.29 | |
| Shares (Basic) | 44,258,338 | 9,891,126 | 1,928,586 | |
| Shares (Diluted) | 44,258,338 | 9,891,126 | 2,177,124 | |
| EBITDA | $-67M | $-79M | · |
Balance general 23
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Cash & Equivalents | $121M | $238M | $88M | |
| Short-term Investments | $270M | $113M | $0 | |
| Receivables | $10M | $171.0K | $151.0K | |
| Prepaid Expense | $10M | $6M | $1M | |
| Other Current Assets | $1M | $239.0K | $92.0K | |
| Current Assets | $411M | $357M | $113M | |
| PP&E (Net) | $4M | $5M | $5M | |
| PP&E (Gross) | $9M | $8M | $6M | |
| Accum. Depreciation | $4M | $3M | $2M | |
| Other Non-current Assets | $816.0K | $267.0K | $97.0K | |
| Total Assets | $596M | $457M | $131M | |
| Accounts Payable | $10M | $3M | $3M | |
| Accrued Liabilities | $12M | $8M | $4M | |
| Current Liabilities | $87M | $13M | $7M | |
| Capital Leases | $21M | $24M | $13M | |
| Other Non-current Liabilities | $0 | $33.0K | $546.0K | |
| Total Liabilities | $214M | $37M | $20M | |
| Common Stock | $45.0K | $44.0K | $3.0K | |
| Retained Earnings | $-167M | $-118M | $-47M | |
| AOCI | $617.0K | $56.0K | $0 | |
| Stockholders' Equity | $382M | $420M | $-38M | |
| Liabilities + Equity | $596M | $457M | $131M | |
| Shares Outstanding | 44,806,272 | 44,422,505 | 3,168,134 |
Flujo de Efectivo 11
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| D&A | $2M | $1M | $800.0K | |
| Stock-based Comp | $8M | $3M | $2M | |
| Deferred Tax | $0 | $-491.0K | $491.0K | |
| Other Non-cash | $149M | $267.0K | · | |
| Operating Cash Flow | $110M | $-67M | $-39M | |
| CapEx | $518.0K | $2M | $3M | |
| Investing Cash Flow | $-229M | $-161M | $22M | |
| Financing Cash Flow | $2M | $378M | $75M | |
| Net Change in Cash | $-117M | $150M | $58M | |
| Taxes Paid | $0 | $232.0K | $75.0K | |
| Free Cash Flow | $110M | $-70M | · |
Rentabilidad 7
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Operating Margin | -148.6% | -7518.4% | · | |
| Net Margin | -106.4% | -6678.9% | · | |
| Pretax Margin | -106.3% | -6725.2% | · | |
| EBITDA Margin | -145.2% | -7388.2% | · | |
| ROA | -9.3% | -24.4% | · | |
| ROE | -12.9% | -43.2% | · | |
| ROIC | -17.9% | -19.1% | · |
Liquidez y Solvencia 2
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Current Ratio | 4.7 | 27.8 | · | |
| Quick Ratio | 4.6 | 27.3 | · |
Eficiencia 2
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Asset Turnover | 0.1 | 0.0 | · | |
| Receivables Turnover | 8.7 | 6.7 | · |
Tasas de Crecimiento 1
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue YoY | 4174.5% | 611.9% | · |
Valoración (TTM) 10
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue TTM | $46M | $1M | · | |
| Net Income TTM | $-49M | $-72M | · | |
| Market Cap | $1.25B | $1.02B | · | |
| P/E | -25.3 | -3.2 | · | |
| P/S | 27.2 | 946.3 | · | |
| P/B | 3.3 | 2.4 | · | |
| P / Tangible Book | 3.3 | 2.4 | · | |
| P / Cash Flow | 11.3 | -15.1 | · | |
| P / FCF | 11.4 | -14.6 | · | |
| Earnings Yield | -4.0% | -31.7% | · |
Estado de resultados 15
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $27M | $27M | $24M | $21M | $119.0K | $219.0K | $212.0K | $176.0K | $370.0K | $317.0K | |
| R&D Expense | $35M | $30M | $32M | $24M | $22M | $19M | $19M | $18M | $15M | $13M | |
| SG&A Expense | $8M | $10M | $8M | $7M | $7M | $7M | $6M | $5M | $3M | $3M | |
| Operating Expenses | $44M | $40M | $40M | $19M | $29M | $26M | $25M | $23M | $18M | $16M | |
| Operating Income | $-17M | $-13M | $-16M | $3M | $-29M | $-26M | $-25M | $-23M | $-18M | $-15M | |
| Interest Income | $5M | $5M | $5M | $6M | $4M | $4M | $4M | $2M | $2M | $1M | |
| Other Non-op | $-23.0K | $-31.0K | $-41.0K | $-6.0K | $-25.0K | $-28.0K | $-18.0K | $-9.0K | $-15.0K | $-48.0K | |
| Pretax Income | $-12M | $-8M | $-11M | $8M | $-25M | $-21M | $-21M | $-21M | $-17M | $-14M | |
| Income Tax | $973.0K | $337.0K | $12.0K | $0 | $0 | $0 | $-564.0K | $-136.0K | $109.0K | $93.0K | |
| Net Income | $-13M | $-9M | $-11M | $8M | $-25M | $-21M | $-21M | $-21M | $-17M | $-14M | |
| EPS (Basic) | $-0.29 | $-0.19 | $-0.23 | $0.18 | $-0.56 | $-0.49 | $14.52 | $-8.40 | $-7.03 | $-6.35 | |
| EPS (Diluted) | $-0.29 | $-0.19 | $-0.23 | $0.18 | $-0.56 | $-0.49 | $14.52 | $-8.40 | $-7.03 | $-6.35 | |
| Shares (Basic) | 45,040,075 | 44,758,800 | -88,187,325 | 44,343,085 | 44,165,168 | 43,937,410 | 2,877,617 | 2,443,678 | 2,337,585 | 2,232,246 | |
| Shares (Diluted) | 45,040,075 | 44,758,800 | -89,446,339 | 45,602,099 | 44,165,168 | 43,937,410 | 2,877,617 | 2,443,678 | 2,337,585 | 2,232,246 | |
| EBITDA | $-16M | $-13M | · | $3M | $-29M | $-26M | · | $-22M | · | · |
Balance general 23
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $85M | $72M | $121M | $320M | $189M | $210M | $238M | $88M | · | · | |
| Short-term Investments | $288M | $276M | $270M | $154M | $137M | $126M | $113M | $42M | · | · | |
| Receivables | $12M | $11M | $10M | $9M | $151.0K | $250.0K | $171.0K | $210.0K | · | · | |
| Prepaid Expense | $12M | $10M | $10M | $9M | $7M | $6M | $6M | $3M | · | · | |
| Other Current Assets | $133.0K | $110.0K | $1M | $387.0K | $0 | $52.0K | $239.0K | $241.0K | · | · | |
| Current Assets | $396M | $368M | $411M | $492M | $334M | $342M | $357M | $133M | · | · | |
| PP&E (Net) | $4M | $4M | $4M | $4M | $5M | $5M | $5M | $5M | · | · | |
| PP&E (Gross) | $9M | $9M | $9M | $8M | $8M | $8M | $8M | $8M | · | · | |
| Accum. Depreciation | $5M | $5M | $4M | $4M | $4M | $3M | $3M | $3M | · | · | |
| Other Non-current Assets | $1M | $773.0K | $816.0K | $501.0K | $300.0K | $277.0K | $267.0K | $3M | · | · | |
| Total Assets | $567M | $570M | $596M | $607M | $415M | $434M | $457M | $174M | · | · | |
| Accounts Payable | $4M | $7M | $10M | $4M | $7M | $4M | $3M | $6M | · | · | |
| Accrued Liabilities | $13M | $9M | $12M | $8M | $7M | $4M | $8M | $6M | · | · | |
| Current Liabilities | $79M | $78M | $87M | $75M | $15M | $11M | $13M | $13M | · | · | |
| Capital Leases | $20M | $21M | $21M | $22M | $23M | $23M | $24M | $24M | · | · | |
| Other Non-current Liabilities | $521.0K | $100.0K | $0 | $0 | $2.0K | $27.0K | $33.0K | $191.0K | · | · | |
| Total Liabilities | $180M | $191M | $214M | $218M | $38M | $34M | $37M | $38M | · | · | |
| Common Stock | $46.0K | $45.0K | $45.0K | $45.0K | $45.0K | $44.0K | $44.0K | $3.0K | · | · | |
| Retained Earnings | $-189M | $-176M | $-167M | $-157M | $-165M | $-140M | $-118M | $-98M | · | · | |
| AOCI | $-1M | $-569.0K | $617.0K | $375.0K | $176.0K | $198.0K | $56.0K | $176.0K | · | · | |
| Stockholders' Equity | $387M | $378M | $382M | $389M | $378M | $400M | $420M | $-87M | · | · | |
| Liabilities + Equity | $567M | $570M | $596M | $607M | $415M | $434M | $457M | $174M | · | · | |
| Shares Outstanding | 45,667,490 | 44,916,572 | 44,806,272 | 44,638,703 | 44,567,891 | 44,448,435 | 44,422,505 | · | · | · |
Flujo de Efectivo 11
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $300.0K | $300.0K | |
| Stock-based Comp | $5M | $6M | $3M | $3M | $2M | $1M | $1M | $683.0K | $628.0K | $577.0K | |
| Deferred Tax | · | · | · | · | · | · | $-153.0K | $-136.0K | $-109.0K | $-93.0K | |
| Other Non-cash | · | $-23M | · | · | · | $-4M | · | · | · | · | |
| Operating Cash Flow | $-22M | $-26M | $-15M | $169M | $-20M | $-23M | $-21M | $-17M | $-13M | $-17M | |
| CapEx | $0 | $832.0K | $65.0K | $13.0K | $58.0K | $382.0K | $612.0K | $578.0K | $149.0K | $764.0K | |
| Investing Cash Flow | $18M | $-24M | $-185M | $-38M | $-786.0K | $-5M | $-133M | $-25M | $-12M | $10M | |
| Financing Cash Flow | $17M | $333.0K | $1M | $263.0K | $339.0K | $66.0K | $304M | $-1M | · | · | |
| Net Change in Cash | $13M | $-49M | $-199M | $131M | $-21M | $-28M | $150M | $-43M | $50M | $-7M | |
| Taxes Paid | · | · | · | · | · | · | $0 | $75.0K | · | · | |
| Free Cash Flow | · | $-26M | · | · | · | $-24M | · | · | · | · |
Rentabilidad 7
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -62.9% | -50.1% | · | 12.2% | -24351.3% | -11831.1% | · | -12812.5% | · | · | |
| Net Margin | -48.7% | -32.6% | · | 38.0% | -20872.3% | -9806.4% | · | -11660.8% | · | · | |
| Pretax Margin | -45.1% | -31.3% | · | 38.0% | -20872.3% | -9806.4% | · | -11738.1% | · | · | |
| EBITDA Margin | -61.5% | -48.6% | · | 14.0% | -24015.1% | -11648.4% | · | -12585.2% | · | · | |
| ROA | -2.6% | -1.7% | · | 2.1% | -12.0% | -9.9% | · | -23.5% | · | · | |
| ROE | -3.4% | -2.2% | · | 5.4% | -13.2% | -10.7% | · | 47.0% | · | · | |
| ROIC | -4.7% | -3.7% | · | 0.67% | -7.7% | -6.5% | · | 25.6% | · | · |
Liquidez y Solvencia 2
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 5.0 | 4.7 | · | 6.5 | 22.1 | 32.2 | · | 10.1 | · | · | |
| Quick Ratio | 4.8 | 4.6 | · | 6.4 | 21.6 | 31.6 | · | 9.9 | · | · |
Eficiencia 2
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.1 | 0.1 | · | 0.1 | 0.0 | 0.0 | · | 0.0 | · | · | |
| Receivables Turnover | 4.3 | 4.8 | · | 4.9 | 1.6 | 1.8 | · | 1.7 | · | · |
Valoración (TTM) 10
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $75M | $48M | · | $22M | $884.0K | $1M | · | $896.0K | · | · | |
| Net Income TTM | $-38M | $-47M | · | $-59M | $-83M | $-73M | · | $-62M | · | · | |
| Market Cap | $1.53B | $1.08B | · | $840M | $471M | $257M | · | · | · | · | |
| P/E | -38.9 | -22.7 | · | -2.0 | -0.6 | -0.3 | · | · | · | · | |
| P/S | 20.4 | 22.3 | · | 38.2 | 532.9 | 237.9 | · | · | · | · | |
| P/B | 4.0 | 2.9 | · | 2.2 | 1.2 | 0.6 | · | · | · | · | |
| P / Tangible Book | 4.0 | 2.9 | · | 2.2 | 1.2 | 0.6 | · | · | · | · | |
| P / Cash Flow | · | -42.1 | · | · | · | -11.0 | · | · | · | · | |
| P / FCF | · | -40.8 | · | · | · | -10.8 | · | · | · | · | |
| Earnings Yield | -2.6% | -4.4% | · | -49.3% | -155.9% | -384.6% | · | · | · | · |
Estados Financieros Estado de resultados, balance general, flujo de caja — anual, últimos 5 años
Estado de resultados
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Ingresos | $46M | $1M | $151.0K |
| Margen Operativo % | -148.6% | -7518.4% | — |
| Beneficio neto | $-49M | $-72M | $4M |
| EPS Diluido | $-1.10 | $-7.26 | $0.29 |
Balance general
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Ratio corriente | 4.7 | 27.8 | — |
| Ratio Rápido | 4.6 | 27.3 | — |
Flujo de Efectivo
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Flujo de caja libre | $110M | $-70M | — |
Mis Métricas Tu lista de seguimiento personal — filas seleccionadas de Fundamentales Completos
📊
Elige las métricas que te importan — haz clic en el ➕ junto a cualquier fila en Fundamentales Completos arriba.
Tu selección se guarda y te sigue en todos los tickers.
Propietarios institucionales (13F) 169 declarantes · $1.5B total · A fecha de 30 de junio de 2026
Instituciones que informan tener esta acción en su Formulario 13F trimestral de la SEC. Solo posiciones largas; un solo presentador puede aparecer dos veces para tramos de opciones separados. Las patas de put/call de compensación grandes suelen reflejar la creación de mercado o el inventario cubierto, no la convicción direccional.
Actividad institucional — Q2 2026 vs trimestre anterior
| Nuevas posiciones | Posiciones cerradas | Aumentado | Disminuido | Cambio neto de acciones |
|---|---|---|---|---|
| 55 (+25 vs trimestre anterior) | 15 (-7 vs trimestre anterior) | 46 (+6 vs trimestre anterior) | 33 (+4 vs trimestre anterior) | +1.2M |
Comparado con Q1 2026. Las presentaciones del Formulario 13F de la SEC vencen dentro de los 45 días posteriores al final del trimestre, más un pequeño margen para los presentadores tardíos; los trimestres que aún se encuentran dentro de esa ventana se omiten en favor del par más reciente completamente reportado.
| Institución | Valor | Acciones | % de 13F rastreadas | Tipo |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $234 291 284 | 6 995 858 | 15,96% | Acciones |
| TRV GP V, LLC | $208 160 143 | 6 215 591 | 14,18% | Acciones |
| Driehaus Capital Management LLC | $148 463 112 | 4 433 058 | 10,11% | Acciones |
| TRV GP VI, LLC | $141 048 460 | 4 211 659 | 9,61% | Acciones |
| SAMSARA BIOCAPITAL, LLC | $105 464 297 | 3 149 128 | 7,18% | Acciones |
| Siren, L.L.C. | $63 631 000 | 1 900 000 | 4,33% | Acciones |
| GOLDMAN SACHS GROUP INC | $57 564 688 | 1 718 862 | 3,92% | Acciones |
| Avoro Capital Advisors LLC | $44 792 875 | 1 337 500 | 3,05% | Acciones |
| VANGUARD CAPITAL MANAGEMENT LLC | $40 913 829 | 1 221 673 | 2,79% | Acciones |
| PRIMECAP MANAGEMENT CO/CA/ | $39 095 624 | 1 167 382 | 2,66% | Acciones |
| First Light Asset Management, LLC | $32 259 577 | 963 260 | 2,20% | Acciones |
| ADAR1 Capital Management, LLC | $31 505 617 | 940 747 | 2,15% | Acciones |
| STATE STREET CORP | $21 856 579 | 652 630 | 1,49% | Acciones |
| JANUS HENDERSON GROUP PLC | $21 333 558 | 890 754 | 1,45% | Acciones |
| GEODE CAPITAL MANAGEMENT, LLC | $19 943 040 | 595 346 | 1,36% | Acciones |
| Casdin Capital, LLC | $18 528 945 | 553 268 | 1,26% | Acciones |
| Catalio Capital Management, LP | $17 955 730 | 536 152 | 1,22% | Acciones |
| LOOMIS SAYLES & CO L P | $17 416 173 | 520 041 | 1,19% | Acciones |
| Caption Management, LLC | $14 735 600 | 440 000 | 1,00% | Opción de compra |
| ALGERT GLOBAL LLC | $13 311 840 | 397 487 | 0,91% | Acciones |
| Balyasny Asset Management L.P. | $11 736 303 | 350 442 | 0,80% | Acciones |
| Longaeva Partners L.P. | $9 985 747 | 298 171 | 0,68% | Acciones |
| Soleus Capital Management, L.P. | $9 209 750 | 275 000 | 0,63% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8 774 380 | 262 000 | 0,60% | Opción de compra |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $7 708 862 | 230 184 | 0,52% | Acciones |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $7 458 290 | 222 702 | 0,51% | Acciones |
| TWO SIGMA INVESTMENTS, LP | $7 397 439 | 220 885 | 0,50% | Acciones |
| TUDOR INVESTMENT CORP ET AL | $6 698 000 | 200 000 | 0,46% | Opción de compra |
| Caption Management, LLC | $6 698 000 | 200 000 | 0,46% | Opción de venta |
| Kalehua Capital Management LLC | $6 515 279 | 194 544 | 0,44% | Acciones |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6 264 003 | 187 041 | 0,43% | Acciones |
| Woodline Partners LP | $6 213 567 | 185 535 | 0,42% | Acciones |
| VANGUARD FIDUCIARY TRUST CO | $5 547 819 | 165 656 | 0,38% | Acciones |
| VANGUARD GROUP INC | $4 171 991 | 149 641 | 0,28% | Acciones |
| TUDOR INVESTMENT CORP ET AL | $3 349 000 | 100 000 | 0,23% | Opción de venta |
| CITADEL ADVISORS LLC | $2 739 482 | 81 800 | 0,19% | Opción de compra |
| UBS Group AG | $2 551 067 | 76 174 | 0,17% | Acciones |
| LAZARD ASSET MANAGEMENT LLC | $2 525 983 | 75 425 | 0,17% | Acciones |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2 499 995 | 74 649 | 0,17% | Acciones |
| DIMENSIONAL FUND ADVISORS LP | $2 284 319 | 68 209 | 0,16% | Acciones |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2 283 348 | 68 180 | 0,16% | Acciones |
| HUSSMAN STRATEGIC ADVISORS, INC. | $2 109 870 | 63 000 | 0,14% | Acciones |
| AMERICAN CENTURY COMPANIES INC | $2 041 986 | 60 973 | 0,14% | Acciones |
| DIADEMA PARTNERS LP | $1 999 353 | 59 700 | 0,14% | Opción de venta |
| JANE STREET GROUP, LLC | $1 915 628 | 57 200 | 0,13% | Opción de compra |
| XTX Topco Ltd | $1 824 837 | 54 489 | 0,12% | Acciones |
| MILLENNIUM MANAGEMENT LLC | $1 693 321 | 50 562 | 0,12% | Acciones |
| Elmind Capital, LP | $1 655 880 | 49 444 | 0,11% | Acciones |
| BARCLAYS PLC | $1 647 541 | 49 195 | 0,11% | Acciones |
| Sofinnova Investments, Inc. | $1 590 976 | 47 506 | 0,11% | Acciones |
| D. E. Shaw & Co., Inc. | $1 556 716 | 46 483 | 0,11% | Acciones |
| Voleon Capital Management LP | $1 488 128 | 44 435 | 0,10% | Acciones |
| RENAISSANCE TECHNOLOGIES LLC | $1 387 122 | 41 419 | 0,09% | Acciones |
| Caption Management, LLC | $1 272 821 | 38 006 | 0,09% | Acciones |
| BANK OF AMERICA CORP /DE/ | $1 201 453 | 35 875 | 0,08% | Acciones |
| Alyeska Investment Group, L.P. | $1 172 150 | 35 000 | 0,08% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 135 311 | 33 900 | 0,08% | Opción de venta |
| Brevan Howard Capital Management LP | $986 347 | 29 452 | 0,07% | Acciones |
| HighVista Strategies LLC | $982 496 | 29 337 | 0,07% | Acciones |
| TUDOR INVESTMENT CORP ET AL | $970 071 | 28 966 | 0,07% | Acciones |
| RHUMBLINE ADVISERS | $925 521 | 27 636 | 0,06% | Acciones |
| JANE STREET GROUP, LLC | $871 946 | 26 036 | 0,06% | Acciones |
| Trexquant Investment LP | $858 851 | 25 645 | 0,06% | Acciones |
| Logos Global Management LP | $788 623 | 23 548 | 0,05% | Acciones |
| FMR LLC | $778 308 | 23 240 | 0,05% | Acciones |
| FOX RUN MANAGEMENT, L.L.C. | $738 053 | 22 038 | 0,05% | Acciones |
| ALLIANCEBERNSTEIN L.P. | $718 497 | 29 900 | 0,05% | Acciones |
| TWO SIGMA ADVISERS, LP | $716 516 | 25 700 | 0,05% | Acciones |
| Squarepoint Ops LLC | $710 624 | 21 219 | 0,05% | Acciones |
| STRS OHIO | $703 290 | 21 000 | 0,05% | Acciones |
| FRED ALGER MANAGEMENT, LLC | $701 883 | 20 958 | 0,05% | Acciones |
| Jump Financial, LLC | $676 498 | 20 200 | 0,05% | Acciones |
| Swiss National Bank | $663 102 | 19 800 | 0,05% | Acciones |
| WELLS FARGO & COMPANY/MN | $657 677 | 19 638 | 0,04% | Acciones |
| Aquatic Capital Management LLC | $583 630 | 17 427 | 0,04% | Acciones |
| BlackRock, Inc. | $582 626 | 17 397 | 0,04% | Acciones |
| Engineers Gate Manager LP | $581 052 | 17 350 | 0,04% | Acciones |
| BNP PARIBAS FINANCIAL MARKETS | $567 522 | 16 946 | 0,04% | Acciones |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $555 833 | 16 597 | 0,04% | Acciones |
| CITIGROUP INC | $553 623 | 16 531 | 0,04% | Acciones |
| Nuveen Asset Management, LLC | $548 707 | 23 961 | 0,04% | Acciones |
| State of Wyoming | $548 533 | 16 379 | 0,04% | Acciones |
| Vanguard Global Advisers, LLC | $544 112 | 16 247 | 0,04% | Acciones |
| Bank of New York Mellon Corp | $516 650 | 15 427 | 0,04% | Acciones |
| AQR CAPITAL MANAGEMENT LLC | $510 421 | 15 241 | 0,03% | Acciones |
| Verdad Advisers, LP | $434 365 | 12 970 | 0,03% | Acciones |
| MetLife Investment Management, LLC | $431 351 | 12 880 | 0,03% | Acciones |
| Man Group plc | $384 097 | 11 469 | 0,03% | Acciones |
| FEDERATED HERMES, INC. | $368 055 | 10 990 | 0,03% | Acciones |
| China Universal Asset Management Co., Ltd. | $360 821 | 10 774 | 0,02% | Acciones |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $341 364 | 10 193 | 0,02% | Acciones |
| Gotham Asset Management, LLC | $312 194 | 9 322 | 0,02% | Acciones |
| Virtus Investment Advisers, LLC | $304 826 | 9 102 | 0,02% | Acciones |
| CANADA PENSION PLAN INVESTMENT BOARD | $298 061 | 8 900 | 0,02% | Acciones |
| Invesco Ltd. | $285 737 | 8 532 | 0,02% | Acciones |
| NEW YORK STATE COMMON RETIREMENT FUND | $284 665 | 8 500 | 0,02% | Acciones |
| FIRST TRUST ADVISORS LP | $259 179 | 7 739 | 0,02% | Acciones |
| VANGUARD ASSET MANAGEMENT, Ltd | $248 496 | 7 420 | 0,02% | Acciones |
| Quantinno Capital Management LP | $245 482 | 7 330 | 0,02% | Acciones |
| Rangeley Capital, LLC | $241 128 | 7 200 | 0,02% | Acciones |
Informantes de la empresa 15 insiders · 6 directivos · 8 consejeros
| Insider | Rol | Última actividad | Acciones en propiedad | Compras 12m | Ventas 12m | Neto 12m |
|---|---|---|---|---|---|---|
| Jeffrey Finer | Chief Executive Officer | 6 de febrero de 2026 A | 826 907 | 0 | 0 | $0 |
| Gil M Labrucherie | Chief Financial Officer | 6 de febrero de 2026 A | 40 000 | 0 | 0 | $0 |
| Samira Shaikhly | Chief People Officer | 29 de junio de 2026 M | 793 | 0 | 8 | $-2 802 156 |
| Uwe Klein | SVP, Biological Sciences | 6 de febrero de 2026 A | 23 008 | 0 | 0 | $0 |
| Jae B. Kim | Chief Medical Officer | 6 de febrero de 2026 A | — | 0 | 0 | $0 |
| Mark Andrew Wilson | Chief Legal Officer | 6 de febrero de 2026 A | — | 0 | 0 | $0 |
| Abraham Bassan | Consejero | 26 de junio de 2026 A | — | 0 | 0 | $0 |
| Jake Simson | Consejero | 26 de junio de 2026 A | — | 0 | 0 | $0 |
| Bernard Coulie | Consejero | 26 de junio de 2026 A | — | 0 | 0 | $0 |
| Alan Ezekowitz | Consejero | 26 de junio de 2026 A | 117 420 | 0 | 0 | $0 |
| Keith Michael Gottesdiener | Consejero | 26 de junio de 2026 A | — | 0 | 0 | $0 |
| Jeffrey K Tong | Consejero | 26 de junio de 2026 A | — | 0 | 0 | $0 |
| Shalini Sharp | Consejero | 26 de junio de 2026 A | — | 0 | 0 | $0 |
| Elizabeth Bhatt | — | 11 de agosto de 2026 M | 174 209 | 0 | 7 | $-1 449 169 |
| Daniel D. Long | — | 3 de agosto de 2026 M | 96 412 | 0 | 7 | $-825 272 |
Informantes de las presentaciones SEC Form 3/4/5; neto = solo P/S de mercado abierto
Activistas y propietarios del %+ 5 1 tenencia
Inversores que presentaron el Anexo 13D de la SEC — propiedad beneficiosa superior al % 5 con la intención de influir en el emisor (participaciones activistas, campañas de la junta directiva, M&A). Cada fila muestra el estado conocido más reciente de la posición de ese declarante.
| Declarante | Presentado | Participación | Estado | Propósito | Presentación |
|---|---|---|---|---|---|
| RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. ×2 presentaciones | 14 de agosto de 2026 | 11,80% | Enmienda | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Propiedad de ETFs Mantenido por 42 ETFs
El peso refleja solo las tenencias directas de acciones (N-PORT); los fondos apalancados o basados en derivados pueden tener exposición adicional a swaps no mostrada.
| Fondo | Ponderación | Unidades | A fecha de | Fuente |
|---|---|---|---|---|
| PILL · Direxion Shares ETF Trust | 0,69% | 3 760 NS | 30 de abril de 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0,69% | 10 849 NS | 30 de abril de 2026 | N-PORT |
| MMSC · First Trust Exchange-Traded Fund VI… | 0,44% | 7 698 NS | 31 de mayo de 2026 | N-PORT |
| IHE · iShares Trust | 0,20% | 84 469 SH | 21 de agosto de 2026 | Diario |
| SYZ · Lazard Active ETF Trust | 0,17% | 3 405 NS | 30 de junio de 2026 | N-PORT |
| FSCC · Federated Hermes ETF Trust | 0,14% | 12 566 NS | 31 de mayo de 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,12% | 2 641 SH | 21 de agosto de 2026 | Diario |
| VFMO · VANGUARD WELLINGTON FUND | 0,08% | 48 858 SH | 19 de agosto de 2026 | Diario |
| IBB · iShares Trust | 0,08% | 205 741 SH | 21 de agosto de 2026 | Diario |
| BIB · ProShares Trust | 0,07% | 1 657 NS | 31 de mayo de 2026 | N-PORT |
| AVSC · AMERICAN CENTURY ETF TRUST | 0,06% | 51 545 NS | 31 de mayo de 2026 | N-PORT |
| JPSE · J.P. Morgan Exchange-Traded Fund Tr… | 0,04% | 10 731 NS | 30 de abril de 2026 | N-PORT |
| IWO · iShares Trust | 0,04% | 138 834 SH | 21 de agosto de 2026 | Diario |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0,03% | 15 806 SH | 19 de agosto de 2026 | Diario |
| IWM · iShares Trust | 0,03% | 569 598 SH | 21 de agosto de 2026 | Diario |
| ISCG · iShares Trust | 0,03% | 6 294 SH | 21 de agosto de 2026 | Diario |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0,02% | 127 487 SH | 19 de agosto de 2026 | Diario |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0,02% | 6 423 SH | 19 de agosto de 2026 | Diario |
| IWN · iShares Trust | 0,02% | 69 141 SH | 21 de agosto de 2026 | Diario |
| OMFS · Invesco Exchange-Traded Self-Indexe… | 0,02% | 1 228 SH | 21 de agosto de 2026 | Diario |
| ITWO · ProShares Trust | 0,02% | 1 006 NS | 31 de mayo de 2026 | N-PORT |
| RB · ProShares Trust | 0,02% | 6 NS | 31 de mayo de 2026 | N-PORT |
| RSSL · Global X Funds | 0,02% | 9 265 NS | 30 de abril de 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,01% | 108 128 NS | 31 de mayo de 2026 | N-PORT |
| ISCB · iShares Trust | 0,01% | 906 SH | 21 de agosto de 2026 | Diario |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0,01% | 8 841 SH | 21 de agosto de 2026 | Diario |
| VXF · VANGUARD INDEX FUNDS | 0,01% | 263 629 SH | 19 de agosto de 2026 | Diario |
| UWM · ProShares Trust | 0,01% | 787 NS | 31 de mayo de 2026 | N-PORT |
| URTY · ProShares Trust | 0,01% | 797 NS | 31 de mayo de 2026 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0,00% | 17 360 NS | 31 de mayo de 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0,00% | 5 127 NS | 30 de abril de 2026 | N-PORT |
| HDG · ProShares Trust | 0,00% | 20 NS | 31 de mayo de 2026 | N-PORT |
| DFAS · Dimensional ETF Trust | 0,00% | 16 325 NS | 30 de abril de 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,00% | 675 NS | 31 de mayo de 2026 | N-PORT |
| IWV · iShares Trust | 0,00% | 6 897 SH | 21 de agosto de 2026 | Diario |
| ITOT · iShares Trust | 0,00% | 29 867 SH | 21 de agosto de 2026 | Diario |
| SCHB · SCHWAB STRATEGIC TRUST | 0,00% | 11 580 NS | 31 de mayo de 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0,00% | 418 NS | 30 de abril de 2026 | N-PORT |
| AVUS · AMERICAN CENTURY ETF TRUST | 0,00% | 672 NS | 31 de mayo de 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0,00% | 927 665 SH | 19 de agosto de 2026 | Diario |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0,00% | 1 866 SH | 19 de agosto de 2026 | Diario |
| VHT · VANGUARD WORLD FUND | 0,00% | 29 744 SH | 19 de agosto de 2026 | Diario |