UPB Upstream Bio, Inc. - Common Stock
$7,03
Precio · Ago 19, 2026
Fundamentales a fecha de Ago 11, 2026
Rango 52S
$6–$34
4% of range
Calificación del Analista
BUY
13 analysts
Precio Objetivo
$38
+444% upside
P/E (TTM)
-2.6
ROE
-38.3%
Margen de Beneficio Neto
-5026.0%
UPB Instantánea de la Acción Precio, capitalización bursátil, P/E, BPA, ROE, deuda/capital, rango de 52 semanas
Precio
$7.03
Capitalización Bursátil
$381M
P/E (TTM)
-2.6
BPA (TTM)
$-2.66
Ingresos (TTM)
$3M
Rendimiento div.
—
ROE
-38.3%
Deuda/Capital
—
Rango 52S
$6 – $34
UPB Gráfico del Precio de la Acción OHLCV diario con indicadores técnicos — desplace, amplíe y personalice su vista
Configure
Rendimiento a 10 años Tendencias de ingresos, beneficio neto, márgenes y BPA
Ingresos y Beneficio Neto
$3M
2023-12-31
→
2025-12-31
BPA
$-2.66
2023-12-31
→
2025-12-31
Flujo de caja libre
$-133M
2024-12-31
→
2025-12-31
Márgenes
-5026.0%
Valoración Ratios P/E, P/S, P/B, EV/EBITDA: ¿está la acción cara o barata?
Métrica
Tendencia a 5 años
UPB
Mediana de Pares
P/E (TTM)
-2.6
4.6
P/S (TTM) (P/V (TTM))
133.6
9.4
P/B (P/C)
1.1
3.7
Price / FCF (Precio / FCF)
-2.9
—
Rentabilidad Márgenes brutos, operativos y netos; ROE, ROA, ROIC
Métrica
Tendencia a 5 años
UPB
Mediana de Pares
Operating Margin (Margen Operativo)
-5618.8%
—
Net Profit Margin (Margen de Beneficio Neto)
-5026.0%
-186.4%
ROA
-34.3%
-48.0%
ROE
-38.3%
-67.6%
Salud financiera Deuda, liquidez, solvencia — solidez del balance general
Métrica
Tendencia a 5 años
UPB
Mediana de Pares
Current Ratio (Ratio corriente)
26.2
5.2
Quick Ratio (Ratio Rápido)
25.4
—
Crecimiento Crecimiento de ingresos, BPA y beneficio neto: interanual, CAGR a 3 años, CAGR a 5 años
Métrica
Tendencia a 5 años
UPB
Mediana de Pares
Revenue YoY (Ingresos interanuales)
20.4%
—
Eficiencia de capital Rotación de activos, rotación de inventario, rotación de cuentas por cobrar
Métrica
Tendencia a 5 años
UPB
Mediana de Pares
UPB Consenso de analistas Opiniones de analistas alcistas y bajistas, precio objetivo a 12 meses, potencial alcista
COMPRA
13 analistas
- Compra fuerte 2 15,4%
- Compra 8 61,5%
- Mantener 3 23,1%
- Venta 0 0,0%
- Venta fuerte 0 0,0%
Precio objetivo a 12 meses
8 analistas · 2026-08-13
Mediana
$39.50
← Por Debajo de Todos los Objetivos
$7.03
Mín
$8.00
Máx
$75.00
Objetivo mediano
$39.50
+461,9%
Objetivo medio
$38.25
+444,1%
Historial de Ganancias EPS real vs estimado, sorpresa %, tasa de aciertos, próxima fecha de resultados
Sorpresa Media
-0.18%
| Período | EPS Actual | EPS est. | Sorpresa |
|---|---|---|---|
| 31 de marzo de 2026 | $-0.75 | $-0.78 | 0.03% |
| 31 de diciembre de 2025 | $-0.79 | $-0.71 | -0.08% |
| 30 de septiembre de 2025 | $-0.63 | $-0.79 | 0.16% |
| 30 de junio de 2025 | $-0.74 | $-0.62 | -0.12% |
| 31 de marzo de 2025 | $-0.51 | $-0.49 | -0.02% |
| 31 de diciembre de 2024 | $-1.59 | $-0.57 | -1.0% |
Comparación de pares (subindustria GICS) Métricas clave frente a competidores del sector
| Ticker | Capitalización Bursátil | P/E | Ingresos interanuales | Margen Neto | ROE | Margen Bruto |
|---|---|---|---|---|---|---|
| UPB | $1.47B | -10.2 | 20.4% | -5026.0% | -38.3% | — |
| FENC | $263M | -22.6 | -6.1% | -21.8% | -69.6% | — |
| LXEO | $725M | -5.3 | — | — | -51.9% | — |
| FHTX | $306M | -4.6 | 36.8% | -240.3% | 80.2% | — |
| XFOR | $364M | -2.1 | 150.0% | -1218.5% | -83.2% | — |
| PALI | $375M | -7.8 | — | — | -25.4% | — |
| RCKT | — | — | — | — | — | — |
Fundamentales Completos Todas las métricas por año — estado de resultados, balance general, flujo de caja
Estado de resultados 14
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue | $3M | $2M | $2M | |
| R&D Expense | $137M | $63M | $32M | |
| SG&A Expense | $26M | $17M | $11M | |
| Operating Expenses | $163M | $80M | $42M | |
| Operating Income | $-160M | $-78M | $-40M | |
| Interest Income | $17M | $12M | $4M | |
| Other Non-op | $17M | $15M | $20M | |
| Income Tax | $0 | $0 | $0 | |
| Net Income | $-143M | $-63M | $-21M | |
| EPS (Basic) | $-2.66 | $-5.58 | $-12.95 | |
| EPS (Diluted) | $-2.66 | $-5.58 | $-12.95 | |
| Shares (Basic) | 53,852,752 | 13,682,326 | 2,953,756 | |
| Shares (Diluted) | 53,852,752 | 13,682,326 | 2,953,756 | |
| EBITDA | $-160M | $-78M | · |
Balance general 22
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Cash & Equivalents | $102M | $326M | $26M | |
| Short-term Investments | $240M | $145M | $84M | |
| Receivables | $668.0K | $613.0K | $98.0K | |
| Prepaid Expense | $10M | $8M | $7M | |
| Other Current Assets | $727.0K | · | · | |
| Current Assets | $352M | $479M | $117M | |
| PP&E (Net) | $559.0K | $582.0K | $159.0K | |
| PP&E (Gross) | $903.0K | $738.0K | $226.0K | |
| Accum. Depreciation | $344.0K | $156.0K | $67.0K | |
| Goodwill | · | $0 | · | |
| Total Assets | $354M | $482M | $117M | |
| Accounts Payable | $3M | $4M | $2M | |
| Current Liabilities | $13M | $11M | $7M | |
| Capital Leases | $549.0K | $1M | · | |
| Total Liabilities | $14M | $12M | $9M | |
| Common Stock | $54.0K | $53.0K | $3.0K | |
| Paid-in Capital | $673M | $661M | $5M | |
| Retained Earnings | $-334M | $-191M | $-128M | |
| AOCI | $530.0K | $-25.0K | $21.0K | |
| Stockholders' Equity | $340M | $470M | $-123M | |
| Liabilities + Equity | $354M | $482M | $117M | |
| Shares Outstanding | 54,237,750 | 53,603,398 | 2,992,479 |
Flujo de Efectivo 9
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| D&A | $188.0K | $89.0K | $60.0K | |
| Stock-based Comp | $10M | $6M | $3M | |
| Other Non-cash | $-352.0K | $-2M | · | |
| Operating Cash Flow | $-133M | $-59M | $-38M | |
| CapEx | $165.0K | $511.0K | $144.0K | |
| Investing Cash Flow | $-93M | $-59M | $-83M | |
| Financing Cash Flow | $2M | $419M | $130M | |
| Net Change in Cash | $-224M | $300M | $9M | |
| Free Cash Flow | $-133M | $-60M | · |
Rentabilidad 5
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Operating Margin | -5618.8% | -3281.2% | · | |
| Net Margin | -5026.0% | -2650.0% | · | |
| EBITDA Margin | -5612.2% | -3277.4% | · | |
| ROA | -34.3% | -21.0% | · | |
| ROE | -38.3% | -40.6% | · |
Liquidez y Solvencia 2
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Current Ratio | 26.2 | 44.6 | · | |
| Quick Ratio | 25.4 | 43.9 | · |
Eficiencia 2
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | |
| Receivables Turnover | 4.5 | 6.7 | · |
Tasas de Crecimiento 1
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue YoY | 20.4% | -0.42% | · |
Valoración (TTM) 10
| Métrica | Tendencia | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue TTM | $3M | $2M | · | |
| Net Income TTM | $-143M | $-63M | · | |
| Market Cap | $1.47B | $881M | · | |
| P/E | -10.2 | -2.9 | · | |
| P/S | 516.0 | 371.8 | · | |
| P/B | 4.3 | 1.9 | · | |
| P / Tangible Book | 4.3 | 1.9 | · | |
| P / Cash Flow | -11.0 | -14.9 | · | |
| P / FCF | -11.0 | -14.8 | · | |
| Earnings Yield | -9.8% | -33.9% | · |
Estado de resultados 14
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $773.0K | $1M | $668.0K | $683.0K | $937.0K | $566.0K | $613.0K | $607.0K | $510.0K | $640.0K | $450.0K | |
| R&D Expense | $36M | $37M | $40M | $33M | $38M | $26M | $22M | $15M | $14M | $12M | $12M | |
| SG&A Expense | $7M | $8M | $7M | $6M | $7M | $7M | $5M | $4M | $4M | $4M | $3M | |
| Operating Expenses | $43M | $45M | $47M | $39M | $45M | $33M | $27M | $20M | $18M | $16M | $15M | |
| Operating Income | $-42M | $-44M | $-46M | $-38M | $-44M | $-32M | $-26M | $-19M | $-18M | $-15M | $-14M | |
| Interest Income | $3M | $3M | $4M | $4M | $4M | $5M | $5M | $3M | $3M | $1M | $2M | |
| Other Non-op | $3M | $3M | $4M | $4M | $4M | $5M | $5M | $3M | $3M | $4M | $2M | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | |
| Net Income | $-40M | $-41M | $-42M | $-34M | $-40M | $-27M | $-21M | $-16M | $-15M | $-11M | $-12M | |
| EPS (Basic) | $-0.73 | $-0.75 | $-0.78 | $-0.63 | $-0.74 | $-0.51 | $12.56 | $-6.96 | $-6.50 | $-4.68 | $-5.05 | |
| EPS (Diluted) | $-0.73 | $-0.75 | $-0.78 | $-0.63 | $-0.74 | $-0.51 | $12.56 | $-6.96 | $-6.50 | $-4.68 | $-5.05 | |
| Shares (Basic) | 54,567,976 | 54,332,319 | -107,466,785 | 53,930,946 | 53,770,868 | 53,617,723 | 4,654,757 | 3,023,155 | 3,008,807 | 2,995,607 | 8,952 | |
| Shares (Diluted) | 54,567,976 | 54,332,319 | -107,466,785 | 53,930,946 | 53,770,868 | 53,617,723 | 4,654,757 | 3,023,155 | 3,008,807 | 2,995,607 | 8,952 | |
| EBITDA | $-42M | $-44M | · | $-38M | $-44M | $-32M | · | $-19M | · | · | · |
Balance general 21
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $79M | $97M | $102M | $72M | $45M | $71M | $326M | $33M | · | · | $26M | |
| Short-term Investments | $182M | $198M | $240M | $300M | $348M | $360M | $145M | $188M | · | · | $84M | |
| Receivables | $772.0K | $1M | $668.0K | $683.0K | $937.0K | $566.0K | $613.0K | $607.0K | · | · | $98.0K | |
| Prepaid Expense | $18M | $21M | $10M | $16M | $24M | $22M | $8M | $6M | · | · | $7M | |
| Other Current Assets | $1M | · | · | · | · | · | · | · | · | · | · | |
| Current Assets | $280M | $316M | $352M | $389M | $418M | $454M | $479M | $227M | · | · | $117M | |
| PP&E (Net) | $460.0K | $510.0K | $559.0K | $616.0K | $544.0K | $539.0K | $582.0K | $578.0K | · | · | $159.0K | |
| PP&E (Gross) | $903.0K | $903.0K | $903.0K | $903.0K | $785.0K | $738.0K | $738.0K | $685.0K | · | · | $226.0K | |
| Accum. Depreciation | $443.0K | $393.0K | $344.0K | $287.0K | $241.0K | $199.0K | $156.0K | $107.0K | · | · | $67.0K | |
| Total Assets | $281M | $318M | $354M | $391M | $421M | $456M | $482M | $233M | · | · | $117M | |
| Accounts Payable | $2M | $2M | $3M | $4M | $3M | $5M | $4M | $5M | · | · | $2M | |
| Current Liabilities | $10M | $14M | $13M | $12M | $11M | $10M | $11M | $11M | · | · | $7M | |
| Capital Leases | $226.0K | $390.0K | $549.0K | $703.0K | $849.0K | $992.0K | $1M | $1M | · | · | · | |
| Total Liabilities | $10M | $14M | $14M | $13M | $12M | $11M | $12M | $12M | · | · | $9M | |
| Common Stock | $54.0K | $54.0K | $54.0K | $56.0K | $54.0K | $53.0K | $53.0K | $3.0K | · | · | $3.0K | |
| Paid-in Capital | $686M | $679M | $673M | $670M | $666M | $663M | $661M | $9M | · | · | $5M | |
| Retained Earnings | $-415M | $-375M | $-334M | $-292M | $-258M | $-218M | $-191M | $-170M | · | · | $-128M | |
| AOCI | $-123.0K | $100.0K | $530.0K | $493.0K | $258.0K | $368.0K | $-25.0K | $351.0K | · | · | $21.0K | |
| Stockholders' Equity | $271M | $304M | $340M | $379M | $409M | $446M | $470M | $-160M | · | · | $-123M | |
| Liabilities + Equity | $281M | $318M | $354M | $391M | $421M | $456M | $482M | $233M | · | · | $117M | |
| Shares Outstanding | 54,771,041 | 54,419,986 | 54,237,750 | 53,999,522 | 53,798,151 | 53,640,895 | 53,603,398 | 3,025,452 | · | · | 2,992,479 |
Flujo de Efectivo 8
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $50.0K | $49.0K | $57.0K | $46.0K | $42.0K | $43.0K | $49.0K | $14.0K | $13.0K | $13.0K | $14.0K | |
| Stock-based Comp | $4M | $5M | $3M | $3M | $3M | $3M | $2M | $2M | $1M | $643.0K | $711.0K | |
| Other Non-cash | · | $-12M | · | · | · | $-17M | · | · | · | · | · | |
| Operating Cash Flow | $-36M | $-48M | $-31M | $-22M | $-39M | $-41M | $-20M | $-14M | $-8M | $-18M | $-16M | |
| CapEx | · | · | $54.0K | $64.0K | · | · | $185.0K | · | · | · | $0 | |
| Investing Cash Flow | $16M | $42M | $59M | $48M | $13M | $-213M | $42M | $1M | $-117M | $14M | $-5M | |
| Financing Cash Flow | $3M | $598.0K | $1M | $760.0K | $612.0K | $-34.0K | $271M | $-2M | $141M | $9M | $-133.0K | |
| Net Change in Cash | $-17M | $-5M | $29M | $27M | $-26M | $-255M | $293M | $-14M | $16M | $6M | $-21M |
Rentabilidad 5
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -5481.0% | -4218.1% | · | -5539.4% | -4732.9% | -5656.0% | · | -3112.5% | · | · | · | |
| Net Margin | -5136.1% | -3925.6% | · | -4941.1% | -4265.3% | -4818.0% | · | -2634.6% | · | · | · | |
| EBITDA Margin | -5481.0% | -4213.3% | · | -5539.4% | -4732.9% | -5648.4% | · | -3112.5% | · | · | · | |
| ROA | -11.3% | -10.5% | · | -10.8% | -19.0% | -12.0% | · | -13.7% | · | · | · | |
| ROE | -11.7% | -10.8% | · | -30.9% | -19.6% | -12.2% | · | 20.0% | · | · | · |
Liquidez y Solvencia 2
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 28.0 | 23.1 | · | 32.7 | 38.3 | 47.4 | · | 20.9 | · | · | · | |
| Quick Ratio | 26.2 | 21.6 | · | 31.3 | 36.1 | 45.1 | · | 20.3 | · | · | · |
Eficiencia 2
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | 0.0 | 0.0 | 0.0 | · | 0.0 | · | · | · | |
| Receivables Turnover | 0.9 | 1.3 | · | 1.1 | 2.0 | 2.0 | · | 2.0 | · | · | · |
Valoración (TTM) 9
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $3M | $3M | · | $3M | $3M | $2M | · | $2M | · | · | · | |
| Net Income TTM | $-154M | $-142M | · | $-117M | $-98M | $-69M | · | $-45M | · | · | · | |
| Market Cap | $379M | $490M | · | $1.02B | $591M | $328M | · | · | · | · | · | |
| P/E | -2.4 | -3.4 | · | -2.1 | -0.7 | -0.3 | · | · | · | · | · | |
| P/S | 110.6 | 152.1 | · | 363.7 | 225.5 | 141.3 | · | · | · | · | · | |
| P/B | 1.4 | 1.6 | · | 2.7 | 1.4 | 0.7 | · | · | · | · | · | |
| P / Tangible Book | 1.4 | 1.6 | · | 2.7 | 1.4 | 0.7 | · | · | · | · | · | |
| P / Cash Flow | · | -10.2 | · | · | · | -8.0 | · | · | · | · | · | |
| Earnings Yield | -41.2% | -29.2% | · | -47.0% | -134.0% | -304.7% | · | · | · | · | · |
Estados Financieros Estado de resultados, balance general, flujo de caja — anual, últimos 5 años
Estado de resultados
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Ingresos | $3M | $2M | $2M |
| Margen Operativo % | -5618.8% | -3281.2% | — |
| Beneficio neto | $-143M | $-63M | $-21M |
| EPS Diluido | $-2.66 | $-5.58 | $-12.95 |
Balance general
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Ratio corriente | 26.2 | 44.6 | — |
| Ratio Rápido | 25.4 | 43.9 | — |
Flujo de Efectivo
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Flujo de caja libre | $-133M | $-60M | — |
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Propietarios institucionales (13F) 157 declarantes · $351.5M total · A fecha de 30 de junio de 2026
Instituciones que informan tener esta acción en su Formulario 13F trimestral de la SEC. Solo posiciones largas; un solo presentador puede aparecer dos veces para tramos de opciones separados. Las patas de put/call de compensación grandes suelen reflejar la creación de mercado o el inventario cubierto, no la convicción direccional.
Actividad institucional — Q2 2026 vs trimestre anterior
| Nuevas posiciones | Posiciones cerradas | Aumentado | Disminuido | Cambio neto de acciones |
|---|---|---|---|---|
| 45 (+1 vs trimestre anterior) | 25 (-11 vs trimestre anterior) | 59 (+14 vs trimestre anterior) | 30 (-4 vs trimestre anterior) | +6.8M |
Comparado con Q1 2026. Las presentaciones del Formulario 13F de la SEC vencen dentro de los 45 días posteriores al final del trimestre, más un pequeño margen para los presentadores tardíos; los trimestres que aún se encuentran dentro de esa ventana se omiten en favor del par más reciente completamente reportado.
| Institución | Valor | Acciones | % de 13F rastreadas | Tipo |
|---|---|---|---|---|
| VANGUARD GROUP INC | $57 916 706 | 2 133 212 | 16,48% | Acciones |
| FMR LLC | $50 318 247 | 7 271 423 | 14,31% | Acciones |
| ORBIMED ADVISORS LLC | $39 399 636 | 5 693 589 | 11,21% | Acciones |
| NORGES BANK | $26 078 843 | 3 768 619 | 7,42% | Acciones |
| Decheng Capital LLC | $18 856 087 | 2 724 868 | 5,36% | Acciones |
| ENAVATE SCIENCES GP, LLC | $17 021 145 | 2 459 703 | 4,84% | Acciones |
| VANGUARD CAPITAL MANAGEMENT LLC | $12 986 999 | 1 876 734 | 3,69% | Acciones |
| MILLENNIUM MANAGEMENT LLC | $7 914 923 | 1 143 775 | 2,25% | Acciones |
| Qube Research & Technologies Ltd | $6 771 220 | 978 500 | 1,93% | Acciones |
| Parkman Healthcare Partners LLC | $6 471 909 | 935 247 | 1,84% | Acciones |
| SEB Asset Management AB | $6 079 022 | 878 473 | 1,73% | Acciones |
| D. E. Shaw & Co., Inc. | $5 795 971 | 837 568 | 1,65% | Acciones |
| Woodline Partners LP | $5 753 849 | 831 481 | 1,64% | Acciones |
| GEODE CAPITAL MANAGEMENT, LLC | $5 539 562 | 800 289 | 1,58% | Acciones |
| STATE STREET CORP | $5 302 955 | 766 323 | 1,51% | Acciones |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4 931 656 | 712 667 | 1,40% | Acciones |
| Y-Intercept (Hong Kong) Ltd | $4 799 401 | 693 555 | 1,37% | Acciones |
| Bain Capital Life Sciences Investors, LLC | $4 158 567 | 600 949 | 1,18% | Acciones |
| BNP PARIBAS FINANCIAL MARKETS | $3 539 898 | 511 546 | 1,01% | Acciones |
| Walleye Capital LLC | $3 449 551 | 498 490 | 0,98% | Acciones |
| Trexquant Investment LP | $3 227 696 | 466 430 | 0,92% | Acciones |
| Point72 Asset Management, L.P. | $3 134 836 | 453 011 | 0,89% | Acciones |
| BANK OF AMERICA CORP /DE/ | $2 710 993 | 391 762 | 0,77% | Acciones |
| Altshuler Shaham Ltd | $2 630 022 | 380 061 | 0,75% | Acciones |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2 475 672 | 357 756 | 0,70% | Acciones |
| SAMSARA BIOCAPITAL, LLC | $2 447 722 | 353 717 | 0,70% | Acciones |
| Propel Bio Management, LLC | $2 424 692 | 350 389 | 0,69% | Acciones |
| WELLINGTON MANAGEMENT GROUP LLP | $2 369 083 | 342 353 | 0,67% | Acciones |
| DIMENSIONAL FUND ADVISORS LP | $2 363 464 | 341 541 | 0,67% | Acciones |
| Squarepoint Ops LLC | $2 013 056 | 290 904 | 0,57% | Acciones |
| Voleon Capital Management LP | $1 973 819 | 285 234 | 0,56% | Acciones |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1 816 196 | 262 456 | 0,52% | Acciones |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1 751 397 | 253 092 | 0,50% | Acciones |
| GOLDMAN SACHS GROUP INC | $1 708 666 | 246 917 | 0,49% | Acciones |
| XTX Topco Ltd | $1 677 034 | 242 346 | 0,48% | Acciones |
| VANGUARD FIDUCIARY TRUST CO | $1 658 143 | 239 616 | 0,47% | Acciones |
| UBS Group AG | $1 624 200 | 234 711 | 0,46% | Acciones |
| Schonfeld Strategic Advisors LLC | $1 562 258 | 225 760 | 0,44% | Acciones |
| SPHERA FUNDS MANAGEMENT LTD. | $1 520 324 | 219 700 | 0,43% | Acciones |
| BlackRock, Inc. | $1 054 823 | 152 431 | 0,30% | Acciones |
| Boxer Capital Management, LLC | $1 038 000 | 150 000 | 0,30% | Acciones |
| RENAISSANCE TECHNOLOGIES LLC | $908 596 | 131 300 | 0,26% | Acciones |
| EntryPoint Capital, LLC | $895 766 | 129 446 | 0,25% | Acciones |
| ALGERT GLOBAL LLC | $820 920 | 118 630 | 0,23% | Acciones |
| AMERICAN CENTURY COMPANIES INC | $541 102 | 78 194 | 0,15% | Acciones |
| Man Group plc | $510 855 | 73 823 | 0,15% | Acciones |
| JPMORGAN CHASE & CO | $505 093 | 72 885 | 0,14% | Acciones |
| ALLIANCEBERNSTEIN L.P. | $465 120 | 51 680 | 0,13% | Acciones |
| Simplify Asset Management Inc. | $429 822 | 62 113 | 0,12% | Acciones |
| ALPS ADVISORS INC | $382 178 | 55 228 | 0,11% | Acciones |
| Quantinno Capital Management LP | $379 479 | 54 838 | 0,11% | Acciones |
| Nuveen Asset Management, LLC | $371 314 | 22 586 | 0,11% | Acciones |
| Virtus Investment Advisers, LLC | $371 175 | 53 638 | 0,11% | Acciones |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $356 949 | 39 661 | 0,10% | Acciones |
| Brevan Howard Capital Management LP | $348 553 | 50 369 | 0,10% | Acciones |
| Swiss National Bank | $332 852 | 48 100 | 0,09% | Acciones |
| MORGAN STANLEY | $311 220 | 44 974 | 0,09% | Acciones |
| Allspring Global Investments Holdings, LLC | $298 819 | 43 182 | 0,09% | Acciones |
| RHUMBLINE ADVISERS | $293 288 | 42 384 | 0,08% | Acciones |
| TWO SIGMA INVESTMENTS, LP | $292 889 | 42 325 | 0,08% | Acciones |
| ExodusPoint Capital Management, LP | $284 031 | 41 045 | 0,08% | Acciones |
| CITIGROUP INC | $265 084 | 38 307 | 0,08% | Acciones |
| Stonepine Capital Management, LLC | $231 349 | 33 432 | 0,07% | Acciones |
| Mariner, LLC | $229 337 | 33 141 | 0,07% | Acciones |
| DEUTSCHE BANK AG\ | $228 561 | 33 029 | 0,07% | Acciones |
| WELLS FARGO & COMPANY/MN | $204 119 | 29 497 | 0,06% | Acciones |
| Bank of New York Mellon Corp | $197 711 | 28 571 | 0,06% | Acciones |
| Quantbot Technologies LP | $194 992 | 28 178 | 0,06% | Acciones |
| BARCLAYS PLC | $193 608 | 27 978 | 0,06% | Acciones |
| AXQ CAPITAL, LP | $187 311 | 27 068 | 0,05% | Acciones |
| nVerses Capital, LLC | $166 280 | 24 029 | 0,05% | Acciones |
| DNB Asset Management AS | $163 312 | 23 600 | 0,05% | Acciones |
| VANGUARD ASSET MANAGEMENT, Ltd | $157 250 | 22 724 | 0,04% | Acciones |
| Graham Capital Management, L.P. | $155 755 | 22 508 | 0,04% | Acciones |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $154 904 | 22 385 | 0,04% | Acciones |
| Verdad Advisers, LP | $150 925 | 21 810 | 0,04% | Acciones |
| MetLife Investment Management, LLC | $144 296 | 20 852 | 0,04% | Acciones |
| SEI INVESTMENTS CO | $138 580 | 20 026 | 0,04% | Acciones |
| WINTON GROUP Ltd | $137 016 | 19 800 | 0,04% | Acciones |
| IEQ CAPITAL, LLC | $135 182 | 19 535 | 0,04% | Acciones |
| DIADEMA PARTNERS LP | $132 124 | 19 093 | 0,04% | Acciones |
| Shay Capital LLC | $124 560 | 18 000 | 0,04% | Acciones |
| Quadrature Capital Ltd | $124 477 | 17 988 | 0,04% | Acciones |
| Entropy Technologies, LP | $121 391 | 17 542 | 0,03% | Acciones |
| STATE OF WISCONSIN INVESTMENT BOARD | $118 090 | 17 065 | 0,03% | Acciones |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $112 222 | 16 217 | 0,03% | Acciones |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $108 886 | 15 735 | 0,03% | Acciones |
| CITADEL ADVISORS LLC | $103 800 | 15 000 | 0,03% | Opción de compra |
| MERCER GLOBAL ADVISORS INC /ADV | $92 396 | 13 352 | 0,03% | Acciones |
| Vanguard Global Advisers, LLC | $90 368 | 13 059 | 0,03% | Acciones |
| Engineers Gate Manager LP | $86 438 | 12 491 | 0,02% | Acciones |
| Invesco Ltd. | $84 611 | 12 227 | 0,02% | Acciones |
| STRS OHIO | $83 040 | 12 000 | 0,02% | Acciones |
| JANE STREET GROUP, LLC | $82 348 | 11 900 | 0,02% | Opción de compra |
| CANADA PENSION PLAN INVESTMENT BOARD | $79 580 | 11 500 | 0,02% | Acciones |
| HSBC HOLDINGS PLC | $77 602 | 10 793 | 0,02% | Acciones |
| JANE STREET GROUP, LLC | $77 324 | 11 174 | 0,02% | Acciones |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $75 428 | 10 017 | 0,02% | Acciones |
| PRELUDE CAPITAL MANAGEMENT, LLC | $73 006 | 10 550 | 0,02% | Acciones |
| AMERIPRISE FINANCIAL INC | $72 570 | 10 487 | 0,02% | Acciones |
Informantes de la empresa 12 insiders · 5 directivos · 7 consejeros
| Insider | Rol | Última actividad | Acciones en propiedad | Compras 12m | Ventas 12m | Neto 12m |
|---|---|---|---|---|---|---|
| Everett Rand Sutherland | Chief Executive Officer | 16 de junio de 2026 S | 70 812 | 0 | 2 | $-32 224 |
| Michael Gray | CFO and COO | 16 de junio de 2026 S | 28 795 | 0 | 2 | $-13 118 |
| Allison Ambrose | General Counsel | 16 de junio de 2026 S | 16 048 | 0 | 2 | $-7 323 |
| Aaron Deykin | Chief Medical Officer | 16 de junio de 2026 S | 33 197 | 0 | 2 | $-13 765 |
| Adam Houghton | Chief Business Officer | 16 de junio de 2026 S | 23 601 | 0 | 2 | $-10 764 |
| Marcella K. Ruddy | Consejero | 9 de junio de 2026 A | — | 0 | 0 | $0 |
| Harold Edward Fleming | Consejero | 9 de junio de 2026 A | — | 0 | 0 | $0 |
| CHIMOVITS EREZ | Consejero | 9 de junio de 2026 A | 4 554 873 | 0 | 0 | $0 |
| Liam Ratcliffe | Consejero | 9 de junio de 2026 A | — | 0 | 0 | $0 |
| Daniella Beckman | Consejero | 9 de junio de 2026 A | — | 0 | 0 | $0 |
| Ronald C Renaud JR | Consejero | 9 de junio de 2026 A | — | 0 | 0 | $0 |
| Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | Propietario del 10% | 15 de octubre de 2024 C | 894 733 | 0 | 0 | $0 |
Informantes de las presentaciones SEC Form 3/4/5; neto = solo P/S de mercado abierto
Activistas y propietarios del %+ 5 2 tenencias
Inversores que presentaron el Anexo 13D de la SEC — propiedad beneficiosa superior al % 5 con la intención de influir en el emisor (participaciones activistas, campañas de la junta directiva, M&A). Cada fila muestra el estado conocido más reciente de la posición de ese declarante.
| Declarante | Presentado | Participación | Estado | Propósito | Presentación |
|---|---|---|---|---|---|
| AI Upstream LLC, Access Industries Holdings LLC, AI Biotechnology LLC, Access Industries Management, LLC, Len Blavatnik | 22 de octubre de 2024 | — | Presentación inicial | Inversión pasiva | SEC |
| OrbiMed Advisors LLC, OrbiMed Capital GP VIII LLC, OrbiMed Advisors Israel II Limited, OrbiMed Israel GP II, L.P. | 17 de octubre de 2024 | — | Presentación inicial | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Propiedad de ETFs Mantenido por 32 ETFs
El peso refleja solo las tenencias directas de acciones (N-PORT); los fondos apalancados o basados en derivados pueden tener exposición adicional a swaps no mostrada.
| Fondo | Ponderación | Unidades | A fecha de | Fuente |
|---|---|---|---|---|
| FMED · Fidelity Covington Trust | 0,51% | 24 900 NS | 31 de mayo de 2026 | N-PORT |
| SBIO · ALPS ETF Trust | 0,29% | 55 699 NS | 31 de mayo de 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0,25% | 10 169 NS | 30 de abril de 2026 | N-PORT |
| FFSM · FIDELITY COVINGTON TRUST | 0,07% | 92 201 NS | 30 de abril de 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,03% | 2 927 SH | 8 de agosto de 2026 | Diario |
| BIB · ProShares Trust | 0,02% | 1 997 NS | 31 de mayo de 2026 | N-PORT |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0,02% | 31 318 SH | 8 de agosto de 2026 | Diario |
| IBB · iShares Trust | 0,02% | 264 706 SH | 8 de agosto de 2026 | Diario |
| AVSC · AMERICAN CENTURY ETF TRUST | 0,02% | 62 606 NS | 31 de mayo de 2026 | N-PORT |
| IWN · iShares Trust | 0,02% | 334 907 SH | 8 de agosto de 2026 | Diario |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0,01% | 202 528 SH | 8 de agosto de 2026 | Diario |
| RSSL · Global X Funds | 0,01% | 14 420 NS | 30 de abril de 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0,01% | 33 677 SH | 8 de agosto de 2026 | Diario |
| IWM · iShares Trust | 0,01% | 902 359 SH | 8 de agosto de 2026 | Diario |
| DFAS · Dimensional ETF Trust | 0,01% | 108 557 NS | 30 de abril de 2026 | N-PORT |
| ITWO · ProShares Trust | 0,01% | 1 544 NS | 31 de mayo de 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,01% | 161 663 NS | 31 de mayo de 2026 | N-PORT |
| UWM · ProShares Trust | 0,00% | 1 208 NS | 31 de mayo de 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0,00% | 11 160 NS | 30 de abril de 2026 | N-PORT |
| URTY · ProShares Trust | 0,00% | 1 224 NS | 31 de mayo de 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,00% | 1 388 NS | 31 de mayo de 2026 | N-PORT |
| HDG · ProShares Trust | 0,00% | 31 NS | 31 de mayo de 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0,00% | 10 145 NS | 30 de abril de 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0,00% | 2 366 NS | 30 de abril de 2026 | N-PORT |
| ITOT · iShares Trust | 0,00% | 49 987 SH | 8 de agosto de 2026 | Diario |
| SCHB · SCHWAB STRATEGIC TRUST | 0,00% | 20 416 NS | 31 de mayo de 2026 | N-PORT |
| IWV · iShares Trust | 0,00% | 9 569 SH | 8 de agosto de 2026 | Diario |
| AVSU · AMERICAN CENTURY ETF TRUST | 0,00% | 34 NS | 31 de mayo de 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0,00% | 386 877 SH | 8 de agosto de 2026 | Diario |
| VTI · VANGUARD INDEX FUNDS | 0,00% | 1 443 025 SH | 8 de agosto de 2026 | Diario |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0,00% | 2 529 SH | 8 de agosto de 2026 | Diario |
| VHT · VANGUARD WORLD FUND | 0,00% | 72 742 SH | 8 de agosto de 2026 | Diario |