ALNY Alnylam Pharmaceuticals, Inc. - Common Stock

NASDAQ · Biotechnology · Lihat di SEC EDGAR ↗
$240,12
Harga · Agu 19, 2026
Fundamental per Jul 30, 2026

Tentang Alnylam Pharmaceuticals, Inc. - Common Stock Tinjauan perusahaan dari Wikipedia

Alnylam Pharmaceuticals, Inc. is an American biopharmaceutical company focused on the discovery, development and commercialization of RNA interference (RNAi) therapeutics for genetically defined diseases. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts. In 2016, Forbes included the company on its "100 Most Innovative Growth Companies" list.

Baca selengkapnya

Alnylam Pharmaceuticals, Inc. is an American biopharmaceutical company focused on the discovery, development and commercialization of RNA interference (RNAi) therapeutics for genetically defined diseases. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts. In 2016, Forbes included the company on its "100 Most Innovative Growth Companies" list.

History

The company is a spin-off from the Max Planck Institute for Biophysical Chemistry. In 2002, Alnylam was founded by scientists Phillip Sharp, Paul Schimmel, David Bartel, Thomas Tuschl, and Phillip Zamore, and by investors Christoph Westphal and John Kennedy Clarke; John Maraganore was the founding CEO. The company was named after Alnilam, a star in Orion's belt. The spelling was modified to make it unique. In 2003, the firm merged with the German pharmaceutical company, Ribopharma AG. The newly formed company also received $24.6 million in funding from private-equity firms. On February 27, 2004, Alnylam Pharmaceuticals filed for an IPO. The company raised $26 million and began trading as ALNY on the Nasdaq stock exchange.

In 2005, the company partnered with Medtronic to develop drug-device combinations to treat neurodegenerative disorders, and in 2006 with Biogen Idec to develop treatments of progressive multifocal leukoencephalopathy. In 2007, it entered into a nonexclusive alliance with Hoffmann-La Roche, in which Alnylam received $331 million in exchange for access to its technology platform. and also partnered with Ionis Pharmaceuticals to found the company Regulus Therapeutics, focused on microRNA therapeutics.

In 2009, the company formed alliances with Cubist Pharmaceuticals and Kyowa Hakko Kirin to market a drug targeted at respiratory syncytial virus. In 2010, it expanded its previous collaboration with Medtronic to include the CHDI Foundation in its Huntington's disease focused research. In 2011, it partnered with GlaxoSmithKline to develop RNAi technology enhancing vaccine production. The company entered into a 10-year alliance with Monsanto in 2012, to develop biotech solutions for the farming industry by developing natural molecules for crop protection. In 2012, it formed a partnership with Sanofi Genzyme to develop a treatment for transthyretin-mediated amyloidosis, a hereditary disease in Asia. In February 2013, it formed a partnership with The Medicines Company to develop a drug to treat a genetic form of high cholesterol.

In July 2013, during a Phase I trial Alnylam demonstrated statistically significant reduction of a protein called transthyretin, or TTR and demonstrated human efficacy with intravenous and subcutaneous modes of administration. In 2014, Sanofi Genzyme acquired a 12 percent stake in Alnylam and increased its rights to several of the company's drugs for $700 million. In a separate transaction Alnylam announced that it had purchased Merck & Co.'s Sirna Therapeutics, for $25 million cash and $150 million in stock. In 2015, the company had $41 million in revenue and a market cap of $5.2 billion.

In 2016, the company purchased land in Norton, Massachusetts to build a manufacturing facility.

In October 2016 the Phase III clinical trial of the company's lead product, revusiran, was halted due to increased deaths in the drug arm of the trial, and the company said it was terminating development of the compound.

On October 10, 2018, Alnylam appoints Margaret Hamburg to Board of Directors. Prior to this, from May 2009 to April 2015, she serves as Commissioner of the U.S. Food and Drug Administration (FDA).

In February 2020, Alnylam appointed former Sanofi CEO Olivier Brandicourt to its board of directors. In 2021, it was announced that Maraganore would step down as CEO, to be succeeded by the company's chief operating officer, Yvonne Greenstreet, on January 1, 2022.

In December 2021, Alnylam submitted a clinical trial authorisation (CTA) application to the Medicines and Healthcare Products Regulatory Agency in the United Kingdom to initiate a Phase 1 study of ALN-APP, an investigational RNAi therapeutic targeting amyloid precursor protein (APP) for the treatment of Alzheimer's disease and cerebral amyloid angiopathy.

On December 22, 2021, Novartis announced that the US Food and Drug Administration (FDA) approved Leqvio (inclisiran), a small interfering RNA (siRNA) therapy to lower low-density lipoprotein cholesterol. Leqvio is indicated in the United States as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with clinical atherosclerotic cardiovascular disease (ASCVD) or heterozygous familial hypercholesterolemia (HeFH) who require additional lowering of LDL-C. The effect of Leqvio on cardiovascular morbidity and mortality is being explored in clinical trials currently underway. Novartis obtained global rights to develop, manufacture and commercialize Leqvio under a license and collaboration agreement with Alnylam Pharmaceuticals.

Alnylam still does not earn money, but writes losses. The losses ("GAAP Operating Loss") from Alnylam were around $650 million in the late 2020. Alnylam expects to achieve net profits financially in 2022 or 2023.

In July 2023, Roche partnered with Alnylam Pharmaceuticals in a deal worth $2.8 billion for the development of a hypertension drug.

Products

In 2016, Alnylam Pharmaceuticals had 18 potential treatments in various development stages in genetic medicine, cardiometabolic disease and hepatic infectious disease.

Patisiran

In late 2016, the company's lead candidate in phase III studies was patisiran, a treatment targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis (ATTR), in patients with the compromised nervous system condition of familial amyloidotic polyneuropathy (FAP).

In August 2018, with its commercial name Onpattro, patisiran received the U.S. regulatory approval to treat polyneuropathy in patients with hereditary ATTR amyloidosis.

FDA on patisiran for cardiomyopathy

In September 2023, the FDA raised doubts about the efficacy of patisiran for treating cardiomyopathy associated with transthyretin-mediated amyloidosis (ATTR-CM). The FDA's Cardiovascular and Renal Drugs Advisory Committee meeting is scheduled for September 13, 2023. Although the APOLLO-B study met key endpoints, the FDA questioned the clinical significance of the results particularly for patients not on background therapy with tafamidis. The FDA is seeking the committee's input on the clinical meaningfulness and patient populations for patisiran use potentially challenging Pfizer's tafamidis dominance in ATTR-CM treatment. A decision on Alnylam's application is expected by October 8, 2023. Patisiran was previously approved in 2018 for hereditary ATTR amyloidosis polyneuropathy, becoming the first RNA interference therapeutic approved by the FDA. The committee meeting chose to deny approval for the treatment of cardiomyopathy of ATTR amyloidosis with patisiran. Note that while patisiran was denied for the indication of cardiomyopathy, it remains an FDA approved treatment for polyneuropathy.

Vutrisiran

Alnylam went on to pursue the development of vutrisiran, which received FDA approval in 2022 and accounted for the majority of reported profit compared to patisiran/Onpattro in 2025.

Sumber: Wikipedia (English), CC BY-SA 4.0 · Lihat di Wikipedia ↗

Wikidata ↗

ALNY Cuplikan Saham Harga, kapitalisasi pasar, P/E, EPS, ROE, utang/ekuitas, kisaran 52 minggu

Harga
$240.12
Kapitalisasi Pasar
$32.04B
P/E (TTM)
103.9
EPS (TTM)
$2.33
Pendapatan (TTM)
$3.71B
Imbal Hasil Dividen
ROE
60.4%
D/E Utang/Ekuitas
Rentang 52M
$198 – $496

ALNY Grafik Harga Saham OHLCV harian dengan indikator teknis — geser, perbesar, dan sesuaikan tampilan Anda

Kinerja 10 Tahun Tren Pendapatan, laba bersih, margin, dan EPS

Pendapatan & Laba Bersih $3.71B
10-point trend, +7775.4%
2016-12-31 2025-12-31
EPS $2.33
7-point trend, +128.7%
2019-12-31 2025-12-31
Arus Kas Bebas $465M
10-point trend, +225.0%
2016-12-31 2025-12-31
Margin 8.5%

Valuasi Rasio P/E, P/S, P/B, EV/EBITDA — apakah sahamnya mahal atau murah?

Metrik
Tren 5 Tahun
ALNY
Median Rekan
P/E (TTM)
5-point trend, +824.6%
103.9
17.7
P/S (TTM)
5-point trend, -41.3%
8.6
6.8
P/B
5-point trend, +92.5%
40.6
6.4
Price / FCF (Harga / FCF)
5-point trend, +498.5%
68.9

Profitabilitas Margin kotor, operasional, dan bersih; ROE, ROA, ROIC

Metrik
Tren 5 Tahun
ALNY
Median Rekan
Operating Margin (Margin Operasi)
5-point trend, +116.1%
13.5%
Net Profit Margin (Margin Laba Bersih)
5-point trend, +108.4%
8.5%
20.3%
ROA
5-point trend, +128.2%
6.8%
11.4%
ROE
5-point trend, +147.6%
60.4%
16.8%
ROIC
5-point trend, +151.2%
61.7%

Kesehatan Keuangan Utang, likuiditas, solvabilitas — kekuatan neraca

Metrik
Tren 5 Tahun
ALNY
Median Rekan
Current Ratio (Rasio Lancar)
5-point trend, -31.6%
2.8
3.4
Quick Ratio (Rasio Cepat)
5-point trend, +13.4%
1.7

Pertumbuhan Pertumbuhan Pendapatan, EPS, dan Laba Bersih: YoY, CAGR 3T, CAGR 5T

Metrik
Tren 5 Tahun
ALNY
Median Rekan
Revenue YoY (Pendapatan YoY)
5-point trend, +339.9%
65.2%
Revenue CAGR 3Y (CAGR Pendapatan 3T)
5-point trend, +339.9%
53.0%
Revenue CAGR 5Y (CAGR Pendapatan 5T)
5-point trend, +339.9%
49.8%

Metrik Per Saham EPS, nilai buku per saham, arus kas per saham, dividen per saham

Metrik
Tren 5 Tahun
ALNY
Median Rekan
EPS (Diluted)
5-point trend, +132.4%
$2.33

Efisiensi Modal Perputaran aset, perputaran persediaan, perputaran piutang

Metrik
Tren 5 Tahun
ALNY
Median Rekan

ALNY Konsensus Analis Opini analis bullish dan bearish, target harga 12 bulan, potensi kenaikan

BELI 37 analis
  • Beli Kuat 8 21,6%
  • Beli 21 56,8%
  • Tahan 8 21,6%
  • Jual 0 0,0%
  • Jual Kuat 0 0,0%

Target Harga 12 Bulan

24 analis · 2026-08-14
Target median $353.50 +47,2%
Target rata-rata $375.76 +56,5%

Riwayat Pendapatan EPS aktual vs perkiraan, kejutan %, tingkat keberhasilan, tanggal pendapatan berikutnya

Kejutan Rata-rata
0.33%
Periode EPS Aktual EPS Estimasi Kejutan
30 Juni 2026 $1.21 $1.59 -0.38%
31 Maret 2026 $1.51 $0.98 0.53%
31 Des. 2025 $0.82 $1.15 -0.33%
30 Sep. 2025 $2.11 $0.76 1.3%
30 Juni 2025 $-0.51 $-0.73 0.22%
31 Maret 2025 $-0.44 $-1.03 0.59%

Perbandingan rekan (sub-industri GICS) Metrik utama vs rekan sektor

Ticker Kapitalisasi Pasar P/E Pendapatan YoY Margin Bersih ROE Margin Kotor
ALNY $52.64B 170.7 65.2% 8.5% 60.4%
REGN $106.21B 18.6 0.99% 31.4% 14.7%
RVMD
NTRA $32.00B -150.7 35.9% -9.0% -14.1%
BIIB $25.84B 20.0 2.2% 13.1% 7.2%
INSM $37.29B -27.1 66.7% -210.5% -128.4%
INCY $19.60B 15.4 21.2% 25.0% 27.6%
MRNA $11.62B -4.1 -39.9% -145.2% -31.3%
UTHR $21.27B 17.5 10.6% 41.9% 18.7% 87.9%
BBIO $14.90B -20.2 126.3% -146.0% 41.2%

Fundamental Lengkap Semua metrik per tahun — laporan laba rugi, neraca, arus kas

Laporan Laba Rugi 17
Data Laporan Laba Rugi Tahunan untuk ALNY
Metrik Tren 202520242023202220212020201920182017201620152014
Revenue 10-point trend, +7775.4% $3.71B $2.25B $1.83B $1.04B $844M $493M $220M $75M $90M $47M · ·
Cost of Revenue 9-point trend, +677166000.00 $677M $307M $268M $140M $115M $74M $25M $2M $0 · · ·
R&D Expense 12-point trend, +593.7% $1.32B $1.13B $1.00B $883M $792M $655M $655M $505M $391M $382M $276M $190M
SG&A Expense 12-point trend, +2619.1% $1.21B $976M $796M $771M $621M $588M $479M $382M $199M $89M $61M $45M
Operating Expenses 12-point trend, +605.2% $3.21B $2.43B $2.11B $1.82B $1.55B $1.32B $1.16B $890M $590M $472M $337M $456M
Operating Income 12-point trend, +223.9% $502M $-177M $-282M $-785M $-709M $-828M $-939M $-815M $-500M $-425M $-296M $-405M
Interest Expense 6-point trend, +121221000.00 · · $121M $156M $143M $84M $0 $0 · · · ·
Interest Income 8-point trend, +280.9% $111M $122M $96M $25M $2M $12M $33M $29M · · · ·
Other Non-op 12-point trend, +186.4% $5M $-181M $-126M $-134M $-2M $57M $21M $25M $-3M $6M $76.0K $2M
Pretax Income 12-point trend, +180.7% $323M $-377M $-434M $-1.13B $-852M $-856M $-885M $-761M $-491M $-410M $-290M $-401M
Income Tax 12-point trend, +123.4% $9M $-99M $7M $4M $680.0K $3M $863.0K $823.0K $0 $0 $0 $-40M
Net Income 12-point trend, +187.1% $314M $-278M $-440M $-1.13B $-853M $-858M $-886M $-761M $-491M $-410M $-290M $-360M
EPS (Basic) 7-point trend, +129.5% $2.39 $-2.18 $-3.52 $-9.30 $-7.20 $-7.46 $-8.11 · · · · ·
EPS (Diluted) 7-point trend, +128.7% $2.33 $-2.18 $-3.52 $-9.30 $-7.20 $-7.46 $-8.11 · · · · ·
Shares (Basic) 7-point trend, +19.9% 131,004,000 127,651,000 124,906,000 121,689,000 118,451,000 114,986,000 109,264,000 · · · · ·
Shares (Diluted) 7-point trend, +23.3% 134,684,000 127,651,000 124,906,000 121,689,000 118,451,000 114,986,000 109,264,000 · · · · ·
EBITDA 12-point trend, +241.8% $557M $-120M $-228M $-741M $-661M $-794M $-922M $-808M $-487M $-409M $-277M $-393M
Neraca 23
Data Neraca Tahunan untuk ALNY
Metrik Tren 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +2104.4% $1.66B $966M $813M $866M $820M $497M $547M $420M $645M $194M $181M $75M
Receivables 12-point trend, +1847.0% $778M $405M $328M $238M $199M $102M $43M $19M $34M $23M $8M $40M
Inventory 8-point trend, +243.7% $83M $79M $89M $129M $86M $75M $56M $24M · · · ·
Prepaid Expense 12-point trend, +2794.5% $282M $117M $126M $133M $88M $63M $80M $74M $40M $22M $17M $10M
Current Assets 12-point trend, +442.7% $4.05B $3.30B $2.98B $2.69B $2.81B $2.61B $1.72B $1.20B $1.76B $672M $1.11B $746M
PP&E (Net) 12-point trend, +2260.4% $513M $503M $526M $523M $502M $465M $425M $321M $182M $115M $28M $22M
PP&E (Gross) 12-point trend, +1132.2% $836M $773M $749M $697M $642M $569M $501M $400M $249M $176M $79M $68M
Accum. Depreciation 12-point trend, +600.1% $323M $270M $223M $173M $140M $104M $76M $79M $67M $61M $51M $46M
Other Non-current Assets 11-point trend, +3942.2% $59M $65M $62M $66M $60M $45M $18M $9M $4M $2M $1M ·
Total Assets 12-point trend, +360.0% $4.97B $4.24B $3.83B $3.55B $3.64B $3.41B $2.40B $1.57B $1.99B $1.26B $1.39B $1.08B
Accounts Payable 12-point trend, +665.8% $116M $88M $56M $98M $73M $52M $50M $60M $28M $54M $17M $15M
Accrued Liabilities 12-point trend, +4461.6% $1.08B $794M $713M $545M $395M $356M $197M $113M $72M $42M $29M $24M
Current Liabilities 12-point trend, +1438.1% $1.47B $1.19B $968M $768M $696M $585M $353M $179M $144M $132M $62M $95M
Capital Leases 7-point trend, -18.5% $225M $230M $243M $261M $281M $293M $276M · · · · ·
Other Non-current Liabilities 11-point trend, +483.7% $8M $5M $308M $213M $99M $38M $9M $5M $4M $3M $1M ·
Total Liabilities 12-point trend, +2814.4% $4.18B $4.17B $4.05B $3.70B $3.06B $2.39B $956M $273M $228M $343M $122M $143M
Long-term Debt 2-point trend, +253.3% · · · · $676M $191M · · · · · ·
Common Stock 12-point trend, +71.5% $1M $1M $1M $1M $1M $1M $1M $1M $997.0K $859.0K $851.0K $772.0K
Retained Earnings 12-point trend, -600.6% $-6.70B $-7.29B $-7.01B $-6.57B $-5.44B $-4.59B $-3.73B $-2.84B $-2.15B $-1.66B $-1.25B $-957M
AOCI 12-point trend, -141.2% $-20M $-35M $-23M $-45M $-33M $-44M $-37M $-33M $-34M $-33M $4M $49M
Stockholders' Equity 12-point trend, -15.7% $789M $67M $-221M $-158M $588M $1.02B $1.44B $1.30B $1.77B $920M $1.26B $936M
Liabilities + Equity 12-point trend, +360.0% $4.97B $4.24B $3.83B $3.55B $3.64B $3.41B $2.40B $1.57B $1.99B $1.26B $1.39B $1.08B
Shares Outstanding 12-point trend, +71.5% 132,376,000 129,294,000 125,794,000 123,925,000 120,182,000 116,427,000 112,188,000 101,177,000 99,667,000 85,941,000 85,090,968 77,202,753
Arus Kas 14
Data Arus Kas Tahunan untuk ALNY
Metrik Tren 202520242023202220212020201920182017201620152014
D&A 12-point trend, +366.7% $56M $57M $54M $44M $48M $35M $17M $15M $12M $15M $19M $12M
Stock-based Comp 12-point trend, +953.3% $348M $272M $222M $231M $166M $140M $175M $158M $93M $76M $46M $33M
Deferred Tax 9-point trend, -2198000.00 $-2M $-107M $-713.0K $-1M $-3M $-3M $-2M $-788.0K $0 · · ·
Other Non-cash 12-point trend, -227.8% $-191M $48M $269M $316M $614.0K $72M $418M $35M $2M $12M $36M $150M
Operating Cash Flow 12-point trend, +416.4% $524M $-8M $104M $-541M $-642M $-615M $-278M $-563M $-383M $-308M $-189M $-166M
CapEx 12-point trend, +555.0% $59M $34M $62M $72M $76M $70M $140M $127M $104M $65M $13M $9M
Investing Cash Flow 10-point trend, +206.0% $436M $-117M $-336M $169M $-273M $-436M $-418M $273M $-290M $143M · ·
Stock Issued 6-point trend, -100.0% · · · · $0 $0 $382M $0 $1.14B · $496M ·
Net Stock Activity 5-point trend, -100.0% · · · · $0 $0 $382M · $1.14B · $496M ·
Financing Cash Flow 10-point trend, -271.6% $-305M $294M $172M $426M $1.25B $995M $823M $65M $1.12B $178M · ·
Net Change in Cash 12-point trend, +3035.6% $690M $154M $-54M $46M $323M $-51M $127M $-224M $452M $13M $106M $22M
Taxes Paid 7-point trend, +3018.4% $15M $14M $6M $3M · · · · · $111.0K $66.0K $-517.0K
Free Cash Flow 12-point trend, +366.5% $465M $-43M $42M $-613M $-718M $-685M $-419M $-690M $-487M $-372M $-202M $-175M
Levered FCF 4-point trend, +89.5% · · $-81M $-770M $-861M $-770M · · · · · ·
Profitabilitas 7
Data Profitabilitas Tahunan untuk ALNY
Metrik Tren 202520242023202220212020201920182017201620152014
Operating Margin 8-point trend, +101.2% 13.5% -7.9% -15.4% -75.7% -83.9% -168.1% -427.5% -1087.6% · · · ·
Net Margin 8-point trend, +100.8% 8.5% -12.4% -24.1% -109.0% -101.0% -174.2% -403.2% -1016.6% · · · ·
Pretax Margin 8-point trend, +100.9% 8.7% -16.8% -23.7% -108.6% -100.9% -173.6% -402.9% -1015.5% · · · ·
EBITDA Margin 8-point trend, +101.4% 15.0% -5.3% -12.5% -71.4% -78.3% -161.0% -419.7% -1079.0% · · · ·
ROA 12-point trend, +114.2% 6.8% -6.9% -11.9% -31.5% -24.2% -29.6% -44.6% -42.7% -30.1% -31.0% -23.5% -48.0%
ROE 12-point trend, +201.0% 60.4% -559.4% 227.8% 1001.6% -126.9% -76.9% -58.2% -54.8% -36.5% -37.5% -26.4% -59.7%
ROIC 10-point trend, +258.6% 61.7% -194.3% 129.9% 498.0% -120.6% -81.8% -65.4% -62.6% · · -23.4% -38.9%
Likuiditas & Solvabilitas 3
Data Likuiditas & Solvabilitas Tahunan untuk ALNY
Metrik Tren 202520242023202220212020201920182017201620152014
Current Ratio 12-point trend, -64.7% 2.8 2.8 3.1 3.5 4.0 4.5 4.9 6.7 12.2 5.1 17.8 7.8
Quick Ratio 12-point trend, +37.5% 1.7 1.2 1.2 1.4 1.5 1.0 1.7 2.4 4.7 1.6 3.0 1.2
Interest Coverage 4-point trend, +76.3% · · -2.3 -5.0 -5.0 -9.8 · · · · · ·
Efisiensi 3
Data Efisiensi Tahunan untuk ALNY
Metrik Tren 202520242023202220212020201920182017201620152014
Asset Turnover 8-point trend, +1821.0% 0.8 0.6 0.5 0.3 0.2 0.2 0.1 0.0 · · · ·
Inventory Turnover 8-point trend, +5511.3% 8.4 3.7 2.5 1.3 1.4 1.2 0.6 0.1 · · · ·
Receivables Turnover 8-point trend, +121.1% 6.3 6.1 6.5 4.8 5.6 6.8 7.1 2.8 · · · ·
Per Saham 5
Data Per Saham Tahunan untuk ALNY
Metrik Tren 202520242023202220212020201920182017201620152014
Book Value / Share 12-point trend, -50.8% $5.96 $0.52 $-1.75 $-1.28 $4.89 $8.73 $12.82 $12.87 $17.72 $10.71 $14.86 $12.13
Revenue / Share 5-point trend, +286.9% $27.58 $17.61 $14.64 $8.53 $7.13 · · · · · · ·
Cash Flow / Share 5-point trend, +171.8% $3.89 $-0.07 $0.83 $-4.45 $-5.42 · · · · · · ·
Cash / Share 12-point trend, +1185.6% $12.52 $7.47 $6.46 $6.99 $6.82 $4.27 $4.88 $4.15 $6.48 $2.25 $2.13 $0.97
EPS (TTM) 7-point trend, +128.7% $2.33 $-2.18 $-3.52 $-9.30 $-7.20 $-7.46 $-8.11 · · · · ·
Tingkat Pertumbuhan 3
Data Tingkat Pertumbuhan Tahunan untuk ALNY
Metrik Tren 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, -8.6% 65.2% 23.0% 76.2% 22.9% 71.3% · · · · · · ·
Revenue CAGR 3Y 3-point trend, -3.3% 53.0% 38.6% 54.8% · · · · · · · · ·
Revenue CAGR 5Y 49.8% · · · · · · · · · · ·
Valuasi (TTM) 10
Data Valuasi (TTM) Tahunan untuk ALNY
Metrik Tren 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +3623.4% $3.71B $2.25B $1.83B $1.04B $844M $493M $220M $75M $90M $47M $100M $100M
Net Income TTM 12-point trend, +187.1% $314M $-278M $-440M $-1.13B $-853M $-858M $-886M $-761M $-491M $-410M $-290M $-360M
Market Cap 12-point trend, +602.9% $52.64B $30.42B $24.08B $29.45B $20.38B $15.13B $12.92B $7.38B $12.66B $3.22B $8.01B $7.49B
P/E 7-point trend, +1301.8% 170.7 -107.9 -54.4 -25.6 -23.6 -17.4 -14.2 · · · · ·
P/S 12-point trend, -81.1% 14.2 13.5 13.2 28.4 24.1 30.7 58.8 98.5 140.8 68.2 80.3 75.1
P/B 12-point trend, +733.9% 66.7 453.5 -109.1 -186.1 34.6 14.9 9.0 5.7 7.2 3.5 6.3 8.0
P / Tangible Book 4-point trend, +348.0% 66.7 453.5 · · 34.6 14.9 · · · · · ·
P / Cash Flow 12-point trend, +322.2% 100.4 -3660.3 231.2 -54.4 -31.8 -24.6 -46.4 -13.1 -33.1 -10.5 -42.4 -45.2
P / FCF 12-point trend, +363.7% 113.1 -714.4 574.0 -48.0 -28.4 -22.1 -30.9 -10.7 -26.0 -8.6 -39.6 -42.9
Earnings Yield 7-point trend, +108.4% 0.59% -0.93% -1.8% -3.9% -4.2% -5.7% -7.0% · · · · ·

Laporan Keuangan Laporan laba rugi, neraca, arus kas — tahunan, 5 tahun terakhir

Laporan Laba Rugi
2025-12-312024-12-312023-12-312022-12-312021-12-31
Pendapatan $3.71B$2.25B$1.83B$1.04B$844M
Margin Operasi % 13.5%-7.9%-15.4%-75.7%-83.9%
Laba Bersih $314M$-278M$-440M$-1.13B$-853M
EPS Dilusian $2.33$-2.18$-3.52$-9.30$-7.20
Neraca
2025-12-312024-12-312023-12-312022-12-312021-12-31
Rasio Lancar 2.82.83.13.54.0
Rasio Cepat 1.71.21.21.41.5
Arus Kas
2025-12-312024-12-312023-12-312022-12-312021-12-31
Arus Kas Bebas $465M$-43M$42M$-613M$-718M

Berita Terbaru Berita utama terbaru yang menyebutkan perusahaan ini

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Pemilik institusional (13F) 877 pengaju · $27.1B total · Per tanggal 30 Juni 2026

Institusi yang melaporkan kepemilikan saham ini dalam SEC Form 13F triwulanan mereka. Hanya posisi panjang; satu pengaju dapat muncul dua kali untuk leg opsi terpisah. Kaki put/call offset yang besar biasanya mencerminkan pembuatan pasar atau inventaris yang dilindungi, bukan keyakinan arah.

Aktivitas institusional — Q2 2026 vs kuartal sebelumnya
Posisi baru Posisi yang keluar Meningkat Menurun Perubahan bersih saham
99 (-11 vs Kuartal sebelumnya) 77 (-68 vs Kuartal sebelumnya) 328 (+4 vs Kuartal sebelumnya) 259 (+4 vs Kuartal sebelumnya) +15.9M

Dibandingkan dengan Q1 2026. Pengajuan Formulir 13F SEC jatuh tempo dalam waktu 45 hari setelah akhir kuartal ditambah kelonggaran singkat untuk pengaju terlambat — kuartal yang masih dalam jangka waktu tersebut dilewati demi pasangan terakhir yang dilaporkan sepenuhnya.

Institusi Nilai Saham % dari 13F yang dilacak Tipe
Capital World Investors $3.354.715.611 11.144.846 12,36% Saham
FMR LLC $3.108.157.652 10.325.076 11,45% Saham
Capital Research Global Investors $2.935.115.324 9.750.699 10,81% Saham
VANGUARD PORTFOLIO MANAGEMENT LLC $1.968.251.542 6.538.390 7,25% Saham
VANGUARD CAPITAL MANAGEMENT LLC $1.815.053.762 6.029.478 6,69% Saham
STATE STREET CORP $1.070.369.060 3.555.689 3,94% Saham
GEODE CAPITAL MANAGEMENT, LLC $686.853.582 2.288.725 2,53% Saham
NORGES BANK $683.883.867 2.271.813 2,52% Saham
WELLINGTON MANAGEMENT GROUP LLP $614.923.915 2.042.733 2,26% Saham
Dodge & Cox $588.631.955 1.955.393 2,17% Saham
TWO SIGMA INVESTMENTS, LP $564.713.315 1.875.937 2,08% Saham
AMERICAN CENTURY COMPANIES INC $558.098.292 1.853.956 2,06% Saham
TWO SIGMA ADVISERS, LP $450.362.484 1.132.560 1,66% Saham
Clearbridge Investments, LLC $379.142.285 1.259.483 1,40% Saham
MANUFACTURERS LIFE INSURANCE COMPANY, THE $269.059.154 893.795 0,99% Saham
VANGUARD FIDUCIARY TRUST CO $259.723.265 862.782 0,96% Saham
Deep Track Capital, LP $248.349.750 825.000 0,91% Saham
Qube Research & Technologies Ltd $240.437.176 798.715 0,89% Saham
LOS ANGELES CAPITAL MANAGEMENT LLC $219.642.021 729.635 0,81% Saham
BANK OF AMERICA CORP /DE/ $176.408.397 586.016 0,65% Saham
LOOMIS SAYLES & CO L P $170.456.431 566.244 0,63% Saham
BAILLIE GIFFORD & CO $165.849.468 550.940 0,61% Saham
ROYAL BANK OF CANADA $154.998.000 514.893 0,57% Saham
Polar Capital Holdings Plc $145.322.534 482.751 0,54% Saham
Paradigm Biocapital Advisors LP $144.494.400 480.000 0,53% Saham
D. E. Shaw & Co., Inc. $129.533.209 430.300 0,48% Opsi beli
FIRST TRUST ADVISORS LP $126.894.361 421.534 0,47% Saham
Swiss National Bank $112.609.302 374.080 0,41% Saham
WELLS FARGO & COMPANY/MN $111.381.100 370.000 0,41% Opsi beli
BlackRock, Inc. $102.807.465 341.519 0,38% Saham
CANADA PENSION PLAN INVESTMENT BOARD $100.618.073 334.246 0,37% Saham
Sumitomo Mitsui Trust Group, Inc. $97.948.840 325.379 0,36% Saham
SUSQUEHANNA INTERNATIONAL GROUP, LLP $97.804.647 324.900 0,36% Opsi beli
Legal & General Group Plc $97.467.493 323.780 0,36% Saham
MILLENNIUM MANAGEMENT LLC $95.125.781 316.001 0,35% Saham
DIMENSIONAL FUND ADVISORS LP $94.687.695 314.546 0,35% Saham
Candriam S.C.A. $94.586.456 314.512 0,35% Saham
D. E. Shaw & Co., Inc. $93.229.593 309.702 0,34% Saham
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $90.367.000 300.193 0,33% Saham
DEUTSCHE BANK AG\ $89.849.026 298.472 0,33% Saham
SUSQUEHANNA INTERNATIONAL GROUP, LLP $88.641.294 294.460 0,33% Saham
Pictet Asset Management Holding SA $83.257.214 278.613 0,31% Saham
BNP PARIBAS FINANCIAL MARKETS $81.586.054 271.023 0,30% Saham
GILDER GAGNON HOWE & CO LLC $80.992.374 269.051 0,30% Saham
CONGRESS ASSET MANAGEMENT CO $79.983.972 265.701 0,29% Saham
VANGUARD ASSET MANAGEMENT, Ltd $77.578.441 257.710 0,29% Saham
California Public Employees Retirement System $76.477.575 254.053 0,28% Saham
WESTFIELD CAPITAL MANAGEMENT CO LP $75.974.872 252.383 0,28% Saham
Korea Investment CORP $74.553.090 247.660 0,27% Saham
Woodline Partners LP $74.138.270 246.282 0,27% Saham
Squarepoint Ops LLC $70.440.719 233.999 0,26% Saham
TD Asset Management Inc $70.349.507 233.696 0,26% Saham
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $65.136.061 196.863 0,24% Saham
ROYAL LONDON ASSET MANAGEMENT LTD $64.296.696 213.589 0,24% Saham
National Pension Service $59.692.744 198.295 0,22% Saham
PINEBRIDGE INVESTMENTS LLC $58.914.280 195.709 0,22% Saham
Robeco Institutional Asset Management B.V. $56.618.929 188.084 0,21% Saham
SUSQUEHANNA INTERNATIONAL GROUP, LLP $53.824.164 178.800 0,20% Opsi jual
VICTORY CAPITAL MANAGEMENT INC $52.030.628 172.842 0,19% Saham
Mitsubishi UFJ Asset Management Co., Ltd. $50.772.924 168.664 0,19% Saham
RHUMBLINE ADVISERS $49.844.185 165.579 0,18% Saham
Life Cycle Investment Partners Ltd $49.797.587 165.424 0,18% Saham
ANTIPODES PARTNERS Ltd $49.228.339 163.533 0,18% Saham
Universal- Beteiligungs- und Servicegesellschaft mbH $47.228.883 157.223 0,17% Saham
CAPITAL FUND MANAGEMENT S.A. $46.931.781 155.904 0,17% Saham
Assenagon Asset Management S.A. $46.868.866 155.695 0,17% Saham
Vinva Investment Management Ltd $45.487.381 154.972 0,17% Saham
JANUS HENDERSON GROUP PLC $43.671.202 132.000 0,16% Saham
Hudson Bay Capital Management LP $42.204.406 140.200 0,16% Saham
ENVESTNET ASSET MANAGEMENT INC $41.059.106 136.395 0,15% Saham
ProShare Advisors LLC $38.686.569 128.514 0,14% Saham
GOLDMAN SACHS GROUP INC $37.029.700 123.010 0,14% Saham
LMR Partners LLP $35.881.572 119.196 0,13% Saham
Man Group plc $35.798.187 118.919 0,13% Saham
HSBC HOLDINGS PLC $35.754.282 120.600 0,13% Opsi jual
SCS Capital Management LLC $34.783.715 115.549 0,13% Saham
AVIVA PLC $34.477.568 114.532 0,13% Saham
Davern Capital Partners, LP $34.041.978 113.085 0,13% Saham
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM $33.770.750 112.184 0,12% Saham
Longaeva Partners L.P. $33.191.869 110.261 0,12% Saham
683 Capital Management, LLC $32.360.725 107.500 0,12% Opsi jual
MARSHALL WACE, LLP $32.215.929 107.019 0,12% Saham
HighTower Advisors, LLC $31.621.666 105.045 0,12% Saham
Bridgewater Associates, LP $29.977.772 99.584 0,11% Saham
Prosight Management, LP $29.525.022 98.080 0,11% Saham
BNP PARIBAS ASSET MANAGEMENT Holding S.A. $28.956.123 96.408 0,11% Saham
Andra AP-fonden $28.685.436 86.697 0,11% Saham
SCHRODER INVESTMENT MANAGEMENT GROUP $28.376.894 94.266 0,10% Saham
AMERIPRISE FINANCIAL INC $28.191.159 93.649 0,10% Saham
BARCLAYS PLC $27.979.234 92.945 0,10% Saham
TREMBLANT CAPITAL GROUP $27.977.728 92.940 0,10% Saham
FIL Ltd $27.652.616 91.860 0,10% Saham
Balyasny Asset Management L.P. $26.945.195 89.510 0,10% Saham
Caisse de depot et placement du Quebec $25.812.720 85.748 0,10% Saham
Mitsubishi UFJ Trust & Banking Corp $24.911.136 82.753 0,09% Saham
RAYMOND JAMES FINANCIAL INC $24.661.883 81.925 0,09% Saham
CITADEL ADVISORS LLC $24.564.048 81.600 0,09% Opsi beli
VANGUARD GROUP INC $24.356.460 61.251 0,09% Saham
NEOS Investment Management LLC $23.562.822 78.274 0,09% Saham
JONES FINANCIAL COMPANIES LLLP $23.444.213 80.462 0,09% Saham

Orang dalam perusahaan 41 orang dalam · 1 pejabat · 13 direktur

Orang Dalam Peran Aktivitas terakhir Saham dimiliki Beli 12m Jual 12m Bersih 12m
Melissa Mclaughlin Chief Human Resources Officer 6 April 2026 S 9.443 0 14 $-1.274.343
Colleen F Reitan Direktur 20 Mei 2026 A 1.446 0 0 $0
Charles Elliott Sigal Direktur 20 Mei 2026 A 1.446 0 0 $0
Stuart A Arbuckle Direktur 20 Mei 2026 A 671 0 0 $0
Olivier Brandicourt Direktur 20 Mei 2026 A 1.446 0 0 $0
Amy Schulman Direktur 20 Mei 2026 A 24.049 0 0 $0
Dennis A Ausiello Direktur 20 Mei 2026 A 1.582 0 0 $0
Margaret A Hamburg Direktur 20 Mei 2026 A 1.582 0 0 $0
KELLOGG PETER N Direktur 20 Mei 2026 A 1.446 0 0 $0
David E I Pyott Direktur 20 Mei 2026 A 1.582 0 0 $0
Victor J Dzau Direktur 21 Juni 2012 A 0 0 $0
Peter Barrett Direktur 1 Juni 2006 A 5.293 0 0 $0
John E Berriman Direktur 8 Juni 2005 A 2.475 0 0 $0
Christoph H Westphal Direktur 3 Juni 2004 C 2.409.970 0 0 $0
Sanofi Pemilik 10% 31 Mei 2017 P 10.554.134 0 0 $0
ALNYLAM PHARMACEUTICALS, INC. Pemilik 10% 23 Feb. 2016 S 4.896.716 0 0 $0
POLARIS VENTURE MANAGEMENT CO III LLC Pemilik 10% 3 Juni 2004 C 2.409.970 0 0 $0
CHP II LP Pemilik 10% 27 Mei 2004 P 232.500 0 0 $0
Akshay Vaishnaw 10 Agu 2018 A 395 0 0 $0
Barry E Greene 10 Agu 2018 A 9.030 0 0 $0
John Maraganore 10 Agu 2018 A 151.297 0 0 $0
SHARP PHILLIP A 9 Maret 2018 M 140.795 0 0 $0
Michael Mason 4 Jan. 2018 M 0 0 0 $0
Laurie Keating 29 Des. 2017 M 14.500 0 0 $0
Yvonne Greenstreet 20 Des. 2017 A 0 0 $0
David-Alexandre C Gros 20 Des. 2016 A 0 0 $0
SCHIMMEL PAUL 19 Nov. 2015 G 306.996 0 0 $0
Marsha Fanucci 1 Juni 2015 A 10.000 0 0 $0
Steven M Paul 1 Juni 2015 A 0 0 $0
Michael W Bonney 1 Juni 2015 A 0 0 $0
John K Clarke 1 Juni 2015 A 2.091.868 0 0 $0
Kevin P Starr 1 Juni 2015 A 0 0 $0
Laurence Reid 19 Mei 2014 M 3.905 0 0 $0
Kenneth S Koblan 8 Des. 2010 A 0 0 $0
Patricia L Allen 8 Des. 2010 A 0 0 0 $0
James L Vincent 18 Juni 2010 M 0 0 0 $0
Vicki L Sato 2 Juni 2010 A 0 0 $0
Edward M Scolnick 11 Juni 2009 A 0 0 $0
John A Schmidt Jr 9 Des. 2008 A 0 0 $0
Vincent J Miles 7 Des. 2005 A 0 0 $0
Abingworth Management LTD 3 Juni 2004 C 18.745 0 0 $0

Orang dalam dari pengajuan SEC Form 3/4/5; bersih = hanya P/S pasar terbuka

Aktivis & pemilik 5%+ 2 saham

Investor yang mengajukan Jadwal 13D SEC — kepemilikan manfaat di atas 5% dengan niat untuk memengaruhi penerbit (kepemilikan aktivis, kampanye dewan, M&A). Setiap baris menunjukkan status terbaru yang diketahui dari posisi pengaju tersebut.

Pengaju Diajukan Kepemilikan Status Tujuan Pengajuan
CHP II, L.P. IRSN, CHP II Management LLC IRSN, John K. Clarke, Brandon H. Hull, John J. Park, Lisa M. Skeete Tatum ×2 pengajuan 14 Feb. 2007 Pengajuan awal SEC
CHP II, L.P IRSN, CHP II Management LLC IRSN, John K. Clarke, Brandon H. Hull, John J. Park, Lisa M. Skeete Tatum 15 Feb. 2006 Pengajuan awal SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Kepemilikan ETF Dimiliki oleh 150 ETF

Bobot mencerminkan kepemilikan ekuitas langsung (N-PORT) saja; dana berbasis leverage atau derivatif mungkin memiliki eksposur swap tambahan yang tidak ditampilkan.

Dana Bobot Unit Per tanggal Sumber
PBE · Invesco Exchange-Traded Fund Trust 3,25% 53.807 SH 8 Agu 2026 Harian
NUMG · Nushares ETF Trust 3,23% 36.910 NS 30 April 2026 N-PORT
MID · AMERICAN CENTURY ETF TRUST 3,19% 10.523 NS 31 Mei 2026 N-PORT
FMED · Fidelity Covington Trust 2,79% 3.791 NS 31 Mei 2026 N-PORT
IBB · iShares Trust 2,21% 976.319 SH 8 Agu 2026 Harian
HTEC · EXCHANGE TRADED CONCEPTS TRUST 2,01% 3.468 NS 30 April 2026 N-PORT
BIB · ProShares Trust 2,01% 4.904 NS 31 Mei 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 1,99% 7.268 SH 8 Agu 2026 Harian
FDG · AMERICAN CENTURY ETF TRUST 1,94% 26.515 NS 31 Mei 2026 N-PORT
JMID · Janus Detroit Street Trust 1,40% 824 NS 30 April 2026 N-PORT
CAML · Professionally Managed Portfolios 1,29% 15.623 NS 30 April 2026 N-PORT
BBP · ETFis Series Trust I 1,24% 2.379 NS 30 April 2026 N-PORT
HRTS · Tema ETF Trust 1,14% 1.954 NS 31 Mei 2026 N-PORT
MEDI · Harbor ETF Trust 1,08% 966 NS 30 April 2026 N-PORT
LABU · Direxion Shares ETF Trust 0,90% 15.151 NS 30 April 2026 N-PORT
QQQE · Direxion Shares ETF Trust 0,89% 35.072 NS 30 April 2026 N-PORT
VOT · VANGUARD INDEX FUNDS 0,88% 1.022.888 SH 8 Agu 2026 Harian
IWP · iShares Trust 0,82% 770.414 SH 8 Agu 2026 Harian
JOET · Virtus ETF Trust II 0,80% 6.062 NS 30 April 2026 N-PORT
CGGR · Capital Group Growth ETF 0,76% 613.330 NS 31 Mei 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0,66% 60.901 NS 30 April 2026 N-PORT
VHT · VANGUARD WORLD FUND 0,59% 398.693 SH 8 Agu 2026 Harian
FFLG · FIDELITY COVINGTON TRUST 0,58% 11.032 NS 30 April 2026 N-PORT
QNXT · iShares Trust 0,54% 699 SH 8 Agu 2026 Harian
USMV · iShares Trust 0,47% 527.555 SH 8 Agu 2026 Harian
IYH · iShares Trust 0,47% 79.894 SH 8 Agu 2026 Harian
VXF · VANGUARD INDEX FUNDS 0,45% 1.532.109 SH 8 Agu 2026 Harian
UPSD · ETF Series Solutions 0,44% 1.435 NS 30 April 2026 N-PORT
ILDR · First Trust Exchange-Traded Fund VI… 0,43% 4.118 NS 31 Mei 2026 N-PORT
QFLR · Innovator ETFs Trust 0,39% 6.430 NS 30 April 2026 N-PORT
VO · VANGUARD INDEX FUNDS 0,39% 2.893.468 SH 8 Agu 2026 Harian
IMCG · iShares Trust 0,38% 72.243 SH 8 Agu 2026 Harian
FXH · First Trust Exchange-Traded AlphaDE… 0,38% 10.723 NS 30 April 2026 N-PORT
ESMV · iShares Trust 0,35% 128 SH 8 Agu 2026 Harian
SDG · iShares Trust 0,33% 2.658 SH 8 Agu 2026 Harian
SMIZ · Zacks Trust 0,31% 2.688 NS 31 Mei 2026 N-PORT
ESLG · Strategy Shares 0,31% 196 NS 30 April 2026 N-PORT
JDOC · J.P. Morgan Exchange-Traded Fund Tr… 0,31% 112 NS 30 April 2026 N-PORT
HEQQ · J.P. Morgan Exchange-Traded Fund Tr… 0,30% 305 NS 30 April 2026 N-PORT
AVIE · AMERICAN CENTURY ETF TRUST 0,28% 94 NS 31 Mei 2026 N-PORT
HQGO · Lattice Strategies Trust 0,26% 404 NS 30 April 2026 N-PORT
LRND · New York Life Investments ETF Trust 0,24% 2.252 NS 30 April 2026 N-PORT
ESUM · Strategy Shares 0,23% 1.141 NS 30 April 2026 N-PORT
FBCG · FIDELITY COVINGTON TRUST 0,23% 45.231 NS 30 April 2026 N-PORT
JMOM · J.P. Morgan Exchange-Traded Fund Tr… 0,22% 15.559 NS 30 April 2026 N-PORT
QCLR · Global X Funds 0,21% 27 NS 30 April 2026 N-PORT
QYLG · Global X Funds 0,21% 953 NS 30 April 2026 N-PORT
IWR · iShares Trust 0,21% 542.695 SH 8 Agu 2026 Harian
QRMI · Global X Funds 0,21% 108 NS 30 April 2026 N-PORT
QYLD · Global X Funds 0,20% 54.832 NS 30 April 2026 N-PORT