CRSP CRISPR Therapeutics AG - Common Shares

NASDAQ · Biotechnology · Lihat di SEC EDGAR ↗
$52,78
Harga · Agu 18, 2026
Fundamental per Agu 3, 2026

Tentang CRISPR Therapeutics AG - Common Shares Tinjauan perusahaan dari Wikipedia

CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug, Switzerland. The company does business as CRISPR Therapeutics, Inc. in the United States. It was one of the first companies formed to utilize the CRISPR gene editing platform to develop medicines for the treatment of various rare and common diseases. The company has approximately 500 employees and has offices in Zug, Switzerland; Boston, Massachusetts; San Francisco, California; and London, United Kingdom. Its manufacturing facility in Framingham, Massachusetts, won the Facilities of the Year Award (FOYA) award in 2022. The company’s lead program, exagamglogene autotemcel, or exa-cel, was granted regulatory approval by the US Food and Drug Administration (FDA) in December 2023.

Baca selengkapnya

CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug, Switzerland. The company does business as CRISPR Therapeutics, Inc. in the United States. It was one of the first companies formed to utilize the CRISPR gene editing platform to develop medicines for the treatment of various rare and common diseases. The company has approximately 500 employees and has offices in Zug, Switzerland; Boston, Massachusetts; San Francisco, California; and London, United Kingdom. Its manufacturing facility in Framingham, Massachusetts, won the Facilities of the Year Award (FOYA) award in 2022. The company’s lead program, exagamglogene autotemcel, or exa-cel (formerly CTX001), was granted regulatory approval by the US Food and Drug Administration (FDA) in December 2023.

History

CRISPR Therapeutics was founded in 2013 by Emmanuelle Charpentier, Shaun Foy and Rodger Novak. Charpentier later shared the Nobel Prize in Chemistry in 2020 with Jennifer Doudna. As part of a working group, she provided the first scientific documentation on the development and use of CRISPR gene editing. This allows DNA to be specifically modified and edited, which can be used to ameliorate diseases. CRISPR Therapeutics is applying this technology platform to research, develop and commercialize medicines for various diseases including sickle cell disease, beta thalassemia, various cancers, type 1 diabetes, and cardiovascular diseases. The CEO is Samarth Kulkarni, PhD, who joined the company in 2015 as chief business officer. Kulkarni became CEO in 2017.

CRISPR Therapeutics has formed collaborations in support of its mission of developing medicines. Vertex Pharmaceuticals and CRISPR Therapeutics entered into a strategic research collaboration in 2015 focused on the use of CRISPR/Cas9 to discover and develop potential new treatments aimed at the underlying genetic causes of human disease. One of the first treatments to emerge from the joint research program was CTX001 or exagamglogene autotemcel (commonly known as Exa-cel). Subsequently, CRISPR Therapeutics and Vertex expanded their collaboration to include diseases like Duchenne muscular dystrophy and type 1 diabetes. In 2016, the company signed an agreement with Bayer AG to operate Casebia Therapeutics as a joint venture with Bayer under the management of CRISPR Therapeutics. The company went public on the NASDAQ exchange in October 2016.

CRISPR Therapeutics has established partnerships with additional companies such as Viacyte (part of Vertex), Nkarta, Capsida, Curevac, and others.

Products

CRISPR Therapeutics has drugs approved and in development for blood diseases, cancer, diabetes, and other severe diseases.

Exa-cel

Exa-cel is a drug therapy for the treatment of the rare blood disorders beta thalassemia and sickle cell disease developed jointly with Vertex Pharmaceuticals, that received FDA approval for clinical use in December 2023. In May 2020, exa-cel had received orphan drug designation from the US Food and Drug Administration (FDA) for transfusion-dependent beta thalassemia and from the European Medicines Agency for sickle cell disease and transfusion-dependent beta thalassemia. As of 2022 Phase 3 clinical trial results supported the safety and efficacy of this treatment. The rolling Biologics License Applications (BLAs) were submitted to the FDA for exa-cel for sickle cell disease and transfusion-dependent beta thalassemia. EU and UK filings were completed in 2022, and the submissions were validated by European Medicines Agency and The Medicines and Healthcare products Regulatory Agency as of April 2023.

Sumber: Wikipedia (English), CC BY-SA 4.0 · Lihat di Wikipedia ↗

Wikidata ↗

CRSP Cuplikan Saham Harga, kapitalisasi pasar, P/E, EPS, ROE, utang/ekuitas, kisaran 52 minggu

Harga
$52.77
Kapitalisasi Pasar
$5.06B
P/E (TTM)
-8.2
EPS (TTM)
$-6.47
Pendapatan (TTM)
$4M
Imbal Hasil Dividen
ROE
-32.0%
D/E Utang/Ekuitas
Rentang 52M
$44 – $78

CRSP Grafik Harga Saham OHLCV harian dengan indikator teknis — geser, perbesar, dan sesuaikan tampilan Anda

Kinerja 10 Tahun Tren Pendapatan, laba bersih, margin, dan EPS

Pendapatan & Laba Bersih $4M
10-point trend, -32.0%
2016-12-31 2025-12-31
EPS $-6.47
9-point trend, -278.4%
2017-12-31 2025-12-31
Arus Kas Bebas $-346M
10-point trend, -493.1%
2016-12-31 2025-12-31
Margin -16569.8%

Valuasi Rasio P/E, P/S, P/B, EV/EBITDA — apakah sahamnya mahal atau murah?

Metrik
Tren 5 Tahun
CRSP
Median Rekan
P/E (TTM)
5-point trend, -150.3%
-8.2
P/S (TTM)
5-point trend, +22368.1%
1441.8
56.3
P/B
5-point trend, +7.6%
2.6
3.0
Price / FCF (Harga / FCF)
5-point trend, -213.9%
-14.6

Profitabilitas Margin kotor, operasional, dan bersih; ROE, ROA, ROIC

Metrik
Tren 5 Tahun
CRSP
Median Rekan
Operating Margin (Margin Operasi)
5-point trend, -46483.3%
-18933.7%
Net Profit Margin (Margin Laba Bersih)
5-point trend, -40239.9%
-16569.8%
-1643.9%
ROA
5-point trend, -256.5%
-25.8%
-40.2%
ROE
5-point trend, -308.2%
-32.0%
-75.3%
ROIC
5-point trend, -324.7%
-34.8%

Kesehatan Keuangan Utang, likuiditas, solvabilitas — kekuatan neraca

Metrik
Tren 5 Tahun
CRSP
Median Rekan
Current Ratio (Rasio Lancar)
5-point trend, -34.0%
13.3
6.7
Quick Ratio (Rasio Cepat)
5-point trend, -33.2%
13.2

Pertumbuhan Pertumbuhan Pendapatan, EPS, dan Laba Bersih: YoY, CAGR 3T, CAGR 5T

Metrik
Tren 5 Tahun
CRSP
Median Rekan
Revenue YoY (Pendapatan YoY)
5-point trend, -99.6%
-90.6%
Revenue CAGR 3Y (CAGR Pendapatan 3T)
5-point trend, -99.6%
43.1%
Revenue CAGR 5Y (CAGR Pendapatan 5T)
5-point trend, -99.6%
37.3%

Metrik Per Saham EPS, nilai buku per saham, arus kas per saham, dividen per saham

Metrik
Tren 5 Tahun
CRSP
Median Rekan
EPS (Diluted)
5-point trend, -237.7%
$-6.47

Efisiensi Modal Perputaran aset, perputaran persediaan, perputaran piutang

Metrik
Tren 5 Tahun
CRSP
Median Rekan

CRSP Konsensus Analis Opini analis bullish dan bearish, target harga 12 bulan, potensi kenaikan

BELI 29 analis
  • Beli Kuat 6 20,7%
  • Beli 11 37,9%
  • Tahan 12 41,4%
  • Jual 0 0,0%
  • Jual Kuat 0 0,0%

Target Harga 12 Bulan

18 analis · 2026-08-15
Target median $80.00 +51,6%
Target rata-rata $87.56 +65,9%

Riwayat Pendapatan EPS aktual vs perkiraan, kejutan %, tingkat keberhasilan, tanggal pendapatan berikutnya

Kejutan Rata-rata
0.01%
Periode EPS Aktual EPS Estimasi Kejutan
30 Juni 2026 $-0.94 $-1.22 0.28%
31 Maret 2026 $-1.28 $-1.25 -0.03%
31 Des. 2025 $-1.37 $-1.18 -0.19%
30 Sep. 2025 $-1.17 $-1.29 0.12%
30 Juni 2025 $-1.29 $-1.45 0.16%
31 Maret 2025 $-1.58 $-1.28 -0.30%

Perbandingan rekan (sub-industri GICS) Metrik utama vs rekan sektor

Ticker Kapitalisasi Pasar P/E Pendapatan YoY Margin Bersih ROE Margin Kotor
CRSP $5.03B -8.1 -90.6% -16569.8% -32.0%
MLTX -3.7 -60.5%
ACIU
ADCT $444M -3.2 14.8% -175.3% 74.1%

Fundamental Lengkap Semua metrik per tahun — laporan laba rugi, neraca, arus kas

Laporan Laba Rugi 15
Data Laporan Laba Rugi Tahunan untuk CRSP
Metrik Tren 20252024202320222021202020192018201720162015
Revenue 11-point trend, +1321.1% $4M $37M $371M $1M $915M $719.0K $290M $3M $41M $5M $247.0K
R&D Expense 11-point trend, +2165.2% $285M $310M $387M $462M $341M $221M $179M $114M $70M $42M $13M
SG&A Expense 11-point trend, +448.7% $74M $73M $76M $102M $100M $86M $63M $48M $36M $31M $13M
Operating Expenses 11-point trend, +2471.9% $668M $504M $594M $674M $541M $355M $243M $162M $106M $73M $26M
Operating Income 11-point trend, -2483.0% $-665M $-467M $-223M $-673M $374M $-354M $47M $-159M $-65M $-68M $-26M
Interest Income 3-point trend, +347.6% · $104M $76M $23M · · · · · · ·
Other Non-op 11-point trend, +541187.5% $87M $104M $72M $23M $6M $6M $26M $-1M $-197.0K $79M $16.0K
Pretax Income 11-point trend, -2138.4% $-578M $-363M $-151M $-650M $380M $-348M $67M $-164M $-67M $-23M $-26M
Income Tax 11-point trend, +51814.3% $4M $4M $3M $-325.0K $2M $809.0K $448.0K $553.0K $2M $484.0K $7.0K
Net Income 11-point trend, -2180.5% $-582M $-366M $-154M $-650M $378M $-349M $67M $-165M $-68M $-23M $-26M
EPS (Basic) 9-point trend, -278.4% $-6.47 $-4.34 $-1.94 $-8.36 $4.97 $-5.29 $1.23 $-3.44 $-1.71 · ·
EPS (Diluted) 9-point trend, -278.4% $-6.47 $-4.34 $-1.94 $-8.36 $4.70 $-5.29 $1.17 $-3.44 $-1.71 · ·
Shares (Basic) 9-point trend, +124.5% 89,925,109 84,359,126 79,220,930 77,746,575 75,948,686 65,949,672 54,392,304 47,964,368 40,057,365 · ·
Shares (Diluted) 9-point trend, +124.5% 89,925,109 84,359,126 79,220,930 77,746,575 80,393,496 65,949,672 56,932,798 47,964,368 40,057,365 · ·
EBITDA 10-point trend, -859.9% $-645M $-447M $-203M $-649M $391M $-345M $51M $-155M $-62M $-67M ·
Neraca 25
Data Neraca Tahunan untuk CRSP
Metrik Tren 20252024202320222021202020192018201720162015
Cash & Equivalents 11-point trend, +122.8% $348M $298M $389M $212M $923M $1.17B $944M $457M $240M $316M $156M
Short-term Investments 7-point trend, +1628269000.00 $1.63B $1.61B $1.30B $1.60B $1.46B $522M $0 · · · ·
Receivables 11-point trend, -100.0% $0 $25M $200M $0 $305.0K $144.0K $99.0K $88.0K $3M $3M $339.0K
Prepaid Expense 11-point trend, +1722.8% $10M $8M $14M $38M $38M $26M $44M $10M $6M $2M $540.0K
Current Assets 11-point trend, +1166.0% $1.99B $1.94B $1.91B $1.85B $2.42B $1.72B $988M $466M $248M $320M $157M
PP&E (Net) 11-point trend, +8623.7% $116M $134M $152M $164M $138M $42M $31M $18M $19M $21M $1M
PP&E (Gross) 11-point trend, +14678.8% $207M $206M $205M $197M $175M $63M $43M $26M $23M $22M $1M
Accum. Depreciation 11-point trend, +126361.1% $91M $72M $53M $34M $38M $21M $12M $7M $4M $942.0K $72.0K
Intangibles 10-point trend, -100.0% · $0 $16.0K $71.0K $125.0K $180.0K $235.0K $289.0K $344.0K $399.0K $454.0K
Other Non-current Assets 11-point trend, +24026.7% $24M $16M $2M $5M $5M $1M $1M $669.0K $606.0K $198.0K $101.0K
Total Assets 11-point trend, +1320.9% $2.27B $2.24B $2.23B $2.24B $2.75B $1.83B $1.07B $489M $271M $345M $159M
Accounts Payable 11-point trend, +603.2% $11M $15M $38M $27M $15M $9M $6M $5M $2M $5M $2M
Accrued Liabilities 11-point trend, +960.6% $89M $41M $45M $78M $91M $54M $30M $21M $11M $16M $8M
Current Liabilities 11-point trend, +1368.4% $149M $88M $109M $121M $120M $94M $57M $28M $15M $22M $10M
Capital Leases 7-point trend, +327.2% $188M $206M $223M $228M $213M $50M $44M · · · ·
Other Non-current Liabilities 11-point trend, +2085.8% $6M $3M $958.0K $6M $7M $8M $14M $243.0K $314.0K $189.0K $281.0K
Total Liabilities 11-point trend, +176.9% $343M $310M $347M $368M $352M $164M $127M $97M $84M $112M $124M
Long-term Debt $0 · · · · · · · · · ·
Common Stock 11-point trend, +1605.5% $3M $3M $2M $2M $2M $2M $2M $2M $1M $1M $181.0K
Retained Earnings 11-point trend, -5644.0% $-1.95B $-1.37B $-1000M $-846M $-196M $-574M $-225M $-292M $-125M $-57M $-34M
Treasury Stock 11-point trend, +60000.00 $60.0K $62.0K $62.0K $63.0K $63.0K $63.0K $63.0K $57.0K $0 $0 $0
AOCI 11-point trend, +60362.5% $5M $2M $2M $-16M $-5M $-83.0K $7.0K $-8.0K $14.0K $-26.0K $-8.0K
Stockholders' Equity 11-point trend, +6704.8% $1.92B $1.93B $1.88B $1.88B $2.40B $1.66B $939M $392M $188M $233M $-29M
Liabilities + Equity 11-point trend, +1320.9% $2.27B $2.24B $2.23B $2.24B $2.75B $1.83B $1.07B $489M $271M $345M $159M
Shares Outstanding 11-point trend, +1634.7% 95,894,341 85,741,981 80,044,378 78,512,450 76,990,066 73,914,844 60,783,799 51,852,862 40,592,248 39,719,434 5,528,079
Arus Kas 14
Data Arus Kas Tahunan untuk CRSP
Metrik Tren 20252024202320222021202020192018201720162015
D&A 11-point trend, +15237.8% $19M $19M $20M $24M $18M $9M $5M $4M $3M $925.0K $127.0K
Stock-based Comp 11-point trend, +1867.9% $72M $87M $81M $98M $102M $66M $44M $35M $19M $11M $4M
Deferred Tax 11-point trend, +1794.4% $915.0K $-484.0K $-424.0K $-1M $2M $409.0K $-34.0K $6.0K $180.0K $-137.0K $-54.0K
Other Non-cash 10-point trend, +428.3% $144M $118M $-207M $33M $39M $35M $-59M $30M $-24M $-44M ·
Operating Cash Flow 11-point trend, -680.6% $-345M $-143M $-260M $-496M $539M $-238M $57M $-96M $-70M $-53M $59M
CapEx 11-point trend, -20.8% $914.0K $2M $9M $37M $82M $18M $7M $3M $8M $3M $1M
Investing Cash Flow 10-point trend, -199.8% $-32M $-280M $375M $-259M $-1.04B $-541M $1M $-3M $-8M $32M ·
Stock Issued 10-point trend, +347.0% $398M $301M $33M $970.0K $213M $982M $415M $307M $0 $89M ·
Stock Repurchased · · · · · · · $57.0K · · ·
Net Stock Activity 8-point trend, +29.7% $398M $301M $33M $970.0K $213M $982M $415M $307M · · ·
Financing Cash Flow 10-point trend, +132.5% $426M $332M $63M $39M $251M $1.02B $431M $316M $3M $183M ·
Net Change in Cash 11-point trend, -68.2% $49M $-91M $177M $-716M $-246M $237M $489M $217M $-76M $162M $155M
Taxes Paid $3M · · · · · · · · · ·
Free Cash Flow 10-point trend, -493.1% $-346M $-145M $-270M $-533M $457M $-257M $50M $-99M $-78M $-58M ·
Profitabilitas 7
Data Profitabilitas Tahunan untuk CRSP
Metrik Tren 20252024202320222021202020192018201720162015
Operating Margin 10-point trend, -1335.1% -18933.7% -1250.4% -60.0% -56190.4% 40.8% -49295.5% 16.1% -5087.8% -157.7% -1319.3% ·
Net Margin 10-point trend, -3591.9% -16569.8% -981.5% -41.4% -54271.7% 41.3% -48520.9% 23.1% -5281.1% -166.7% -448.8% ·
Pretax Margin 10-point trend, -3642.9% -16466.2% -971.9% -40.6% -54298.8% 41.5% -48408.3% 23.2% -5263.4% -162.5% -439.9% ·
EBITDA Margin 10-point trend, -1312.2% -18378.7% -1198.8% -54.6% -54172.7% 42.8% -48018.2% 17.8% -4975.2% -150.3% -1301.4% ·
ROA 10-point trend, -180.8% -25.8% -16.4% -6.9% -26.0% 16.5% -24.1% 8.6% -43.4% -22.2% -9.2% ·
ROE 10-point trend, -40.7% -32.0% -18.9% -8.5% -34.0% 15.4% -23.2% 8.7% -40.8% -32.5% -22.8% ·
ROIC 10-point trend, -16.5% -34.8% -24.4% -12.0% -35.9% 15.5% -21.3% 4.9% -40.7% -35.3% -29.9% ·
Likuiditas & Solvabilitas 2
Data Likuiditas & Solvabilitas Tahunan untuk CRSP
Metrik Tren 20252024202320222021202020192018201720162015
Current Ratio 10-point trend, -8.5% 13.3 22.1 17.5 15.3 20.2 18.2 17.3 16.8 17.1 14.6 ·
Quick Ratio 10-point trend, -8.5% 13.2 22.0 17.4 15.0 19.8 17.9 16.5 16.5 16.7 14.5 ·
Efisiensi 2
Data Efisiensi Tahunan untuk CRSP
Metrik Tren 20252024202320222021202020192018201720162015
Asset Turnover 10-point trend, -92.2% 0.0 0.0 0.2 0.0 0.4 0.0 0.4 0.0 0.1 0.0 ·
Receivables Turnover 10-point trend, -90.5% 0.3 0.3 3.7 7.9 4075.6 5.9 3097.2 2.3 14.2 3.0 ·
Per Saham 5
Data Per Saham Tahunan untuk CRSP
Metrik Tren 20252024202320222021202020192018201720162015
Book Value / Share 10-point trend, +241.9% $20.04 $22.53 $23.52 $23.89 $31.17 $22.52 $15.46 $7.56 $4.63 $5.86 ·
Revenue / Share 7-point trend, -99.2% $0.04 $0.44 $4.69 $0.02 $11.38 $0.01 $5.09 · · · ·
Cash Flow / Share 7-point trend, -485.4% $-3.84 $-1.69 $-3.29 $-6.38 $6.70 $-3.61 $1.00 · · · ·
Cash / Share 10-point trend, -54.4% $3.62 $3.48 $4.87 $2.70 $11.99 $15.81 $15.53 $8.81 $5.91 $7.94 ·
EPS (TTM) 10-point trend, +8.2% $-6.47 $-4.34 $-1.94 $-8.36 $4.70 $-5.29 $1.17 $-3.44 $-1.71 $-7.05 ·
Tingkat Pertumbuhan 3
Data Tingkat Pertumbuhan Tahunan untuk CRSP
Metrik Tren 20252024202320222021202020192018201720162015
Revenue YoY 5-point trend, -100.1% -90.6% -90.0% 30885.5% -99.9% 127154.9% · · · · · ·
Revenue CAGR 3Y 3-point trend, -93.9% 43.1% -65.6% 702.2% · · · · · · · ·
Revenue CAGR 5Y 37.3% · · · · · · · · · ·
Valuasi (TTM) 10
Data Valuasi (TTM) Tahunan untuk CRSP
Metrik Tren 20252024202320222021202020192018201720162015
Revenue TTM 10-point trend, -32.0% $4M $37M $371M $1M $915M $719.0K $290M $3M $41M $5M ·
Net Income TTM 10-point trend, -2409.4% $-582M $-366M $-154M $-650M $378M $-349M $67M $-165M $-68M $-23M ·
Market Cap 10-point trend, +524.9% $5.03B $3.37B $5.01B $3.19B $5.83B $11.32B $3.70B $1.48B $953M $805M ·
P/E 10-point trend, -182.0% -8.1 -9.1 -32.3 -4.9 16.1 -28.9 52.1 -8.3 -13.7 -2.9 ·
P/S 10-point trend, +819.4% 1432.7 90.4 13.5 2664.0 6.4 15740.1 12.8 474.2 23.2 155.8 ·
P/B 10-point trend, -24.3% 2.6 1.7 2.7 1.7 2.4 6.8 3.9 3.8 5.1 3.5 ·
P / Tangible Book 6-point trend, -61.5% 2.6 1.7 2.7 1.7 2.4 6.8 · · · · ·
P / Cash Flow 10-point trend, -0.2% -14.6 -23.6 -19.2 -6.4 10.8 -47.5 65.3 -15.4 -13.6 -14.5 ·
P / FCF 10-point trend, -5.4% -14.5 -23.3 -18.6 -6.0 12.8 -44.1 74.1 -15.0 -12.2 -13.8 ·
Earnings Yield 10-point trend, +64.5% -12.3% -11.0% -3.1% -20.6% 6.2% -3.5% 1.9% -12.0% -7.3% -34.8% ·

Laporan Keuangan Laporan laba rugi, neraca, arus kas — tahunan, 5 tahun terakhir

Laporan Laba Rugi
2025-12-312024-12-312023-12-312022-12-312021-12-31
Pendapatan $4M$37M$371M$1M$915M
Margin Operasi % -18933.7%-1250.4%-60.0%-56190.4%40.8%
Laba Bersih $-582M$-366M$-154M$-650M$378M
EPS Dilusian $-6.47$-4.34$-1.94$-8.36$4.70
Neraca
2025-12-312024-12-312023-12-312022-12-312021-12-31
Rasio Lancar 13.322.117.515.320.2
Rasio Cepat 13.222.017.415.019.8
Arus Kas
2025-12-312024-12-312023-12-312022-12-312021-12-31
Arus Kas Bebas $-346M$-145M$-270M$-533M$457M

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Pemilik institusional (13F) 573 pengaju · $3.3B total · Per tanggal 30 Juni 2026

Institusi yang melaporkan kepemilikan saham ini dalam SEC Form 13F triwulanan mereka. Hanya posisi panjang; satu pengaju dapat muncul dua kali untuk leg opsi terpisah. Kaki put/call offset yang besar biasanya mencerminkan pembuatan pasar atau inventaris yang dilindungi, bukan keyakinan arah.

Aktivitas institusional — Q2 2026 vs kuartal sebelumnya
Posisi baru Posisi yang keluar Meningkat Menurun Perubahan bersih saham
89 (0 vs Kuartal sebelumnya) 47 (-13 vs Kuartal sebelumnya) 148 (-24 vs Kuartal sebelumnya) 145 (+21 vs Kuartal sebelumnya) +5.4M

Dibandingkan dengan Q1 2026. Pengajuan Formulir 13F SEC jatuh tempo dalam waktu 45 hari setelah akhir kuartal ditambah kelonggaran singkat untuk pengaju terlambat — kuartal yang masih dalam jangka waktu tersebut dilewati demi pasangan terakhir yang dilaporkan sepenuhnya.

Institusi Nilai Saham % dari 13F yang dilacak Tipe
ARK Investment Management LLC $515.999.631 9.460.939 15,58% Saham
Orbis Allan Gray Ltd $296.334.582 5.433.344 8,95% Saham
Capital World Investors $259.039.094 4.749.525 7,82% Saham
STATE STREET CORP $235.703.664 4.321.666 7,12% Saham
GSK plc $175.652.997 3.220.627 5,30% Saham
GEODE CAPITAL MANAGEMENT, LLC $117.453.717 2.153.015 3,55% Saham
SR One Capital Management, LP $111.194.134 2.038.763 3,36% Saham
TWO SIGMA INVESTMENTS, LP $108.459.389 1.988.621 3,27% Saham
Sumitomo Mitsui Trust Group, Inc. $93.848.832 1.720.734 2,83% Saham
Amova Asset Management Americas, Inc. $93.762.487 1.720.097 2,83% Saham
EcoR1 Capital, LLC $75.771.113 1.389.276 2,29% Saham
Capital International Investors $69.178.918 1.268.407 2,09% Saham
VANGUARD CAPITAL MANAGEMENT LLC $64.457.935 1.181.847 1,95% Saham
NEA Management Company, LLC $57.734.408 1.058.570 1,74% Saham
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $57.694.430 1.057.837 1,74% Saham
FMR LLC $53.577.751 982.357 1,62% Saham
D. E. Shaw & Co., Inc. $48.748.506 893.812 1,47% Saham
VANGUARD PORTFOLIO MANAGEMENT LLC $35.380.807 648.713 1,07% Saham
UBS Group AG $32.419.612 594.419 0,98% Saham
VANGUARD FIDUCIARY TRUST CO $31.089.982 570.040 0,94% Saham
VANGUARD GROUP INC $27.714.225 528.494 0,84% Saham
CITADEL ADVISORS LLC $25.404.514 465.796 0,77% Saham
BANK OF AMERICA CORP /DE/ $23.509.740 431.055 0,71% Saham
SUSQUEHANNA INTERNATIONAL GROUP, LLP $23.298.288 427.178 0,70% Saham
MILLENNIUM MANAGEMENT LLC $20.836.025 382.032 0,63% Saham
IQ EQ FUND MANAGEMENT (IRELAND) Ltd $20.833.789 381.991 0,63% Saham
SUSQUEHANNA INTERNATIONAL GROUP, LLP $18.456.336 338.400 0,56% Opsi jual
SUSQUEHANNA INTERNATIONAL GROUP, LLP $17.763.678 325.700 0,54% Opsi beli
Logos Global Management LP $16.362.000 300.000 0,49% Saham
CITADEL ADVISORS LLC $15.822.054 290.100 0,48% Opsi jual
Squarepoint Ops LLC $15.641.472 286.789 0,47% Saham
NORGES BANK $14.767.032 270.756 0,45% Saham
CITADEL ADVISORS LLC $13.973.148 256.200 0,42% Opsi beli
GOLDMAN SACHS GROUP INC $12.748.193 233.740 0,38% Saham
JANE STREET GROUP, LLC $12.566.016 230.400 0,38% Opsi beli
PEAK6 LLC $11.633.382 213.300 0,35% Opsi jual
Swiss National Bank $9.228.168 169.200 0,28% Saham
Susquehanna Portfolio Strategies, LLC $8.945.978 164.026 0,27% Saham
TWO SIGMA ADVISERS, LP $8.516.256 162.400 0,26% Saham
LPL Financial LLC $8.376.280 153.581 0,25% Saham
Bank of New York Mellon Corp $8.337.366 152.867 0,25% Saham
DIMENSIONAL FUND ADVISORS LP $8.301.261 152.205 0,25% Saham
Versant Venture Management, LLC $8.117.243 148.831 0,25% Saham
Pictet Asset Management Holding SA $7.989.776 142.213 0,24% Saham
Life Cycle Investment Partners Ltd $7.836.962 143.692 0,24% Saham
TD Asset Management Inc $7.777.513 142.602 0,23% Saham
AMERICAN CENTURY COMPANIES INC $7.606.257 139.462 0,23% Saham
RAYMOND JAMES FINANCIAL INC $7.230.750 132.577 0,22% Saham
RHUMBLINE ADVISERS $6.627.197 121.511 0,20% Saham
SFE Investment Counsel $6.229.434 16.700 0,19% Opsi jual
Private Advisor Group, LLC $6.060.980 111.129 0,18% Saham
EverSource Wealth Advisors, LLC $6.032.669 110.610 0,18% Saham
CONGRESS ASSET MANAGEMENT CO $5.969.567 109.453 0,18% Saham
BlackRock, Inc. $5.937.061 108.857 0,18% Saham
D. E. Shaw & Co., Inc. $5.901.228 108.200 0,18% Opsi beli
Campbell & CO Investment Adviser LLC $5.864.632 107.529 0,18% Saham
JANE STREET GROUP, LLC $5.852.142 107.300 0,18% Opsi jual
California Public Employees Retirement System $5.599.567 102.669 0,17% Saham
CAPITAL INTERNATIONAL SARL $5.521.521 101.238 0,17% Saham
Affinity Asset Advisors, LLC $5.454.000 100.000 0,16% Saham
ALLIANCEBERNSTEIN L.P. $5.439.011 114.337 0,16% Saham
CLOUGH CAPITAL PARTNERS L P $5.363.300 98.337 0,16% Saham
Zurcher Kantonalbank (Zurich Cantonalbank) $5.172.465 94.838 0,16% Saham
Slow Capital, Inc. $5.066.439 92.894 0,15% Saham
CAPITAL FUND MANAGEMENT S.A. $4.867.258 89.242 0,15% Saham
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $4.815.606 101.232 0,15% Saham
VANGUARD ASSET MANAGEMENT, Ltd $4.720.437 86.550 0,14% Saham
GROUP ONE TRADING LLC $4.638.082 85.040 0,14% Saham
HIMENSION CAPITAL (SINGAPORE) PTE. LTD. $4.575.742 83.897 0,14% Saham
STATE OF MICHIGAN RETIREMENT SYSTEM $4.502.113 82.547 0,14% Saham
Concurrent Investment Advisors, LLC $4.497.728 82.467 0,14% Saham
WELLS FARGO & COMPANY/MN $4.309.151 79.009 0,13% Saham
Fisher Asset Management, LLC $4.251.957 77.960 0,13% Saham
Trexquant Investment LP $4.225.268 77.471 0,13% Saham
COMMONWEALTH EQUITY SERVICES, LLC $4.194.122 76.900 0,13% Saham
JONES FINANCIAL COMPANIES LLLP $4.055.652 73.847 0,12% Saham
Man Group plc $3.992.001 73.194 0,12% Saham
PEAK6 LLC $3.834.162 70.300 0,12% Opsi beli
ENVESTNET ASSET MANAGEMENT INC $3.822.196 70.081 0,12% Saham
ALGERT GLOBAL LLC $3.593.095 65.880 0,11% Saham
Walleye Trading LLC $3.528.738 64.700 0,11% Opsi jual
MILLENNIUM MANAGEMENT LLC $3.146.958 57.700 0,10% Opsi beli
CAPITAL INTERNATIONAL LTD /CA/ $3.057.840 56.066 0,09% Saham
NOMURA HOLDINGS INC $3.055.713 56.027 0,09% Saham
Rafferty Asset Management, LLC $3.045.132 55.833 0,09% Saham
Green Alpha Advisors, LLC $3.043.550 55.804 0,09% Saham
Walleye Trading LLC $3.005.154 55.100 0,09% Opsi beli
Caption Management, LLC $2.999.700 55.000 0,09% Opsi beli
MetLife Investment Management, LLC $2.958.413 54.243 0,09% Saham
BENJAMIN EDWARDS INC $2.956.845 54.216 0,09% Saham
Quantinno Capital Management LP $2.869.349 52.610 0,09% Saham
Cetera Investment Advisers $2.856.133 52.368 0,09% Saham
STATE OF WISCONSIN INVESTMENT BOARD $2.788.521 51.128 0,08% Saham
CITIGROUP INC $2.781.540 51.000 0,08% Opsi beli
CITIGROUP INC $2.781.540 51.000 0,08% Opsi jual
WOLVERINE ASSET MANAGEMENT LLC $2.727.000 50.000 0,08% Opsi jual
OSAIC HOLDINGS, INC. $2.693.150 49.381 0,08% Saham
Privium Fund Management B.V. $2.452.882 44.974 0,07% Saham
CANADA PENSION PLAN INVESTMENT BOARD $2.394.306 43.900 0,07% Saham
TUDOR INVESTMENT CORP ET AL $2.318.604 42.512 0,07% Saham

Orang dalam perusahaan 32 orang dalam · 12 pejabat · 16 direktur

Orang Dalam Peran Aktivitas terakhir Saham dimiliki Beli 12m Jual 12m Bersih 12m
Samarth Kulkarni Chief Executive Officer 20 Maret 2026 M 255.501 0 9 $-10.756.932
Brendan Smith Chief Financial Officer 18 Feb. 2023 M 5.072 0 0 $0
Michael John Tomsicek Chief Financial Officer 11 Maret 2021 M 1.891 0 0 $0
Julianne Bruno Chief Operating Officer 20 Maret 2025 M 10.544 0 0 $0
Lawrence Otto Klein CBO & COO 16 Agu 2022 A 26.797 0 0 $0
Naimish Patel Chief Medical Officer 29 Mei 2026 A 19.357 1 2 $-312.892
James R. Kasinger General Counsel and Secretary 29 Mei 2026 A 94.308 0 5 $-645.902
Phuong Khanh Morrow Chief Medical Officer 13 Okt. 2023 A 4.411 0 0 $0
Tony W Ho Executive VP, Head of R&D 3 Des. 2021 M 52.364 0 0 $0
Tyler Dylan-Hyde Chief Legal Officer 16 Jan. 2018 M 25.204 0 0 $0
Kala Subramanian Senior Vice President, Strategic Development and Operations 15 Juni 2017 A 0 0 $0
Sven Ante Lundberg Chief Scientific Officer 24 Okt. 2016 C 505.617 0 0 $0
Christian Rommel Direktur 5 Juni 2026 A 0 0 $0
Harold Edward Fleming Direktur 5 Juni 2026 A 0 0 $0
Douglas A Treco Direktur 5 Juni 2026 A 0 0 $0
Briggs Morrison Direktur 5 Juni 2026 A 0 0 $0
Katherine A High Direktur 5 Juni 2026 A 0 0 $0
Ali Behbahani Direktur 5 Juni 2026 A 14 0 0 $0
John Greene Direktur 5 Juni 2026 A 7.000 0 0 $0
Simeon George Direktur 5 Juni 2026 A 1.730.179 0 0 $0
Maria Fardis Direktur 5 Juni 2026 A 0 0 $0
Sandesh Mahatme Direktur 5 Juni 2026 A 0 0 $0
Bradley J Bolzon PhD Direktur 9 Juni 2022 A 148.831 0 0 $0
Pablo J Cagnoni Direktur 19 Nov. 2019 M 0 0 0 $0
Kurt Von Emster Direktur 18 Des. 2018 S 1.171.268 0 0 $0
Thomas Woiwode Direktur 15 Juni 2018 A 640.014 0 0 $0
Anthony N Coles Direktur 31 Mei 2017 A 70.000 0 0 $0
CELGENE CORP /DE/ Pemilik 10% 4 Des. 2017 S 3.722.534 0 0 $0
Hadley Harbor Master Investors (Cayman) L.P. Pemilik 10% 24 Okt. 2016 C 744.380 0 0 $0
GSK plc Pemilik 10% 24 Okt. 2016 C 3.220.627 0 0 $0
Raju Prasad 7 Agu 2026 G 14.815 0 10 $-5.100.841
Rodger Novak 30 Juni 2021 S 573.007 0 0 $0

Orang dalam dari pengajuan SEC Form 3/4/5; bersih = hanya P/S pasar terbuka

Aktivis & pemilik 5%+ 6 saham

Investor yang mengajukan Jadwal 13D SEC — kepemilikan manfaat di atas 5% dengan niat untuk memengaruhi penerbit (kepemilikan aktivis, kampanye dewan, M&A). Setiap baris menunjukkan status terbaru yang diketahui dari posisi pengaju tersebut.

Pengaju Diajukan Kepemilikan Status Tujuan Pengajuan
Versant Venture Capital IV, L.P., Versant Side Fund IV, L.P., Versant Ventures IV, LLC, Versant Venture Capital V, L.P., Versant Affiliates Fund V, L.P., Versant Ophthalmic Affiliates Fund I, L.P., Versant Ventures V, LLC, Versant Venture Capital V (Canada) LP, Versant Ventures V GP-GP (Canada), Inc., Versant Ventures V (Canada), L.P., Versant Venture Management, LLC ×5 pengajuan 16 Feb. 2021 Pengajuan awal SEC
GlaxoSmithKline plc ×5 pengajuan 10 Juli 2020 Pengajuan awal SEC
Bayer Global Investments B.V., Bayer AG ×4 pengajuan 4 Feb. 2020 Pengajuan awal SEC
Vertex Pharmaceuticals Incorporated (“Vertex US”), Vertex Pharmaceuticals (Europe) Limited (“Vertex Europe”) ×4 pengajuan 7 Juni 2019 Pengajuan awal SEC
CELGENE ALPINE INVESTMENT CO. III, LLC, CELGENE CORPORATION ×4 pengajuan 8 Feb. 2018 Pengajuan awal SEC
Abingworth LLP 98-051-8585, Abingworth Bioventures VI, LP ×3 pengajuan 16 Jan. 2018 Pengajuan awal SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Kepemilikan ETF Dimiliki oleh 32 ETF

Bobot mencerminkan kepemilikan ekuitas langsung (N-PORT) saja; dana berbasis leverage atau derivatif mungkin memiliki eksposur swap tambahan yang tidak ditampilkan.

Dana Bobot Unit Per tanggal Sumber
GNOM · Global X Funds 3,85% 38.191 NS 31 Mei 2026 N-PORT
IDNA · iShares Trust 1,63% 62.247 SH 8 Agu 2026 Harian
LABU · Direxion Shares ETF Trust 0,98% 97.235 NS 30 April 2026 N-PORT
IBB · iShares Trust 0,36% 658.537 SH 8 Agu 2026 Harian
IBBQ · Invesco Exchange-Traded Fund Trust … 0,35% 5.248 SH 8 Agu 2026 Harian
VTWV · VANGUARD SCOTTSDALE FUNDS 0,28% 70.696 SH 8 Agu 2026 Harian
IWN · iShares Trust 0,27% 752.223 SH 8 Agu 2026 Harian
AVSC · AMERICAN CENTURY ETF TRUST 0,21% 104.016 NS 31 Mei 2026 N-PORT
ISCV · iShares Trust 0,15% 20.568 SH 8 Agu 2026 Harian
IWM · iShares Trust 0,15% 2.353.025 SH 8 Agu 2026 Harian
VTWO · VANGUARD SCOTTSDALE FUNDS 0,15% 536.446 SH 8 Agu 2026 Harian
RSSL · Global X Funds 0,15% 39.589 NS 30 April 2026 N-PORT
PDN · Invesco Exchange-Traded Fund Trust … 0,10% 6.636 SH 8 Agu 2026 Harian
ISCB · iShares Trust 0,07% 4.136 SH 8 Agu 2026 Harian
SMLF · iShares Trust 0,07% 57.970 SH 8 Agu 2026 Harian
VXF · VANGUARD INDEX FUNDS 0,06% 1.106.455 SH 8 Agu 2026 Harian
ESML · iShares Trust 0,06% 33.283 SH 8 Agu 2026 Harian
AVIE · AMERICAN CENTURY ETF TRUST 0,06% 108 NS 31 Mei 2026 N-PORT
WSML · iShares Trust 0,04% 5.486 SH 8 Agu 2026 Harian
VTWG · VANGUARD SCOTTSDALE FUNDS 0,04% 13.170 SH 8 Agu 2026 Harian
IWO · iShares Trust 0,04% 109.974 SH 8 Agu 2026 Harian
OMFS · Invesco Exchange-Traded Self-Indexe… 0,03% 1.736 SH 8 Agu 2026 Harian
XT · iShares Trust 0,03% 21.837 SH 8 Agu 2026 Harian
MSSM · MORGAN STANLEY PATHWAY FUNDS 0,03% 3.509 NS 31 Mei 2026 N-PORT
VTHR · VANGUARD SCOTTSDALE FUNDS 0,01% 7.774 SH 8 Agu 2026 Harian
ESGV · VANGUARD WORLD FUND 0,01% 20.627 SH 8 Agu 2026 Harian
IYY · iShares Trust 0,01% 4.231 SH 8 Agu 2026 Harian
ITOT · iShares Trust 0,01% 128.511 SH 8 Agu 2026 Harian
AVUS · AMERICAN CENTURY ETF TRUST 0,01% 15.609 NS 31 Mei 2026 N-PORT
IWV · iShares Trust 0,01% 25.457 SH 8 Agu 2026 Harian
AVSU · AMERICAN CENTURY ETF TRUST 0,00% 289 NS 31 Mei 2026 N-PORT
VT · VANGUARD INTERNATIONAL EQUITY INDEX… 0,00% 75.392 SH 8 Agu 2026 Harian