| BAKER BROS. ADVISORS LP |
$2,508,182,548 |
8,801,567 |
28.44% |
株式数
|
| PRIMECAP MANAGEMENT CO/CA/ |
$1,427,110,097 |
5,007,931 |
16.18% |
株式数
|
| Capital International Investors |
$1,201,254,811 |
4,210,221 |
13.62% |
株式数
|
| Capital World Investors |
$641,063,383 |
2,249,582 |
7.27% |
株式数
|
| CITADEL ADVISORS LLC |
$399,625,685 |
1,402,343 |
4.53% |
株式数
|
| FMR LLC |
$391,530,827 |
1,373,937 |
4.44% |
株式数
|
| Temasek Holdings (Private) Ltd |
$241,007,393 |
845,729 |
2.73% |
株式数
|
| BlackRock, Inc. |
$162,455,698 |
570,080 |
1.84% |
株式数
|
| MILLENNIUM MANAGEMENT LLC |
$154,830,755 |
543,323 |
1.76% |
株式数
|
| Siren, L.L.C. |
$132,511,050 |
465,000 |
1.50% |
株式数
|
| Baird Financial Group, Inc. |
$105,133,983 |
368,930 |
1.19% |
株式数
|
| Man Group plc |
$87,617,731 |
307,463 |
0.99% |
株式数
|
| Capital International, Inc./CA/ |
$87,051,781 |
305,477 |
0.99% |
株式数
|
| Candriam S.C.A. |
$82,486,344 |
289,735 |
0.94% |
株式数
|
| TWO SIGMA INVESTMENTS, LP |
$81,658,723 |
286,552 |
0.93% |
株式数
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$71,173,537 |
249,758 |
0.81% |
株式数
|
| FIRST TRUST ADVISORS LP |
$70,052,180 |
245,823 |
0.79% |
株式数
|
| M&G PLC |
$63,681,825 |
223,445 |
0.72% |
株式数
|
| BNP PARIBAS FINANCIAL MARKETS |
$52,874,474 |
185,544 |
0.60% |
株式数
|
| CAPITAL INTERNATIONAL SARL |
$50,024,204 |
175,542 |
0.57% |
株式数
|
| GOLDMAN SACHS GROUP INC |
$41,582,537 |
145,919 |
0.47% |
株式数
|
| Artisan Partners Limited Partnership |
$32,878,129 |
115,374 |
0.37% |
株式数
|
| BANK OF AMERICA CORP /DE/ |
$29,211,990 |
102,509 |
0.33% |
株式数
|
| RENAISSANCE TECHNOLOGIES LLC |
$29,061,241 |
101,980 |
0.33% |
株式数
|
| JENNISON ASSOCIATES LLC |
$28,695,909 |
100,698 |
0.33% |
株式数
|
| LAZARD ASSET MANAGEMENT LLC |
$25,746,470 |
90,348 |
0.29% |
株式数
|
| Patient Square Capital LP |
$25,652,999 |
90,020 |
0.29% |
株式数
|
| Qube Research & Technologies Ltd |
$23,162,077 |
81,279 |
0.26% |
株式数
|
| Squarepoint Ops LLC |
$22,387,528 |
78,561 |
0.25% |
株式数
|
| CAPITAL INTERNATIONAL LTD /CA/ |
$21,988,570 |
77,161 |
0.25% |
株式数
|
| Life Cycle Investment Partners Ltd |
$20,816,489 |
73,048 |
0.24% |
株式数
|
| ABN AMRO INVESTMENT SOLUTIONS |
$18,672,374 |
65,524 |
0.21% |
株式数
|
| ENVESTNET ASSET MANAGEMENT INC |
$17,247,905 |
60,525 |
0.20% |
株式数
|
| PANAGORA ASSET MANAGEMENT INC |
$17,050,040 |
59,831 |
0.19% |
株式数
|
| VAN ECK ASSOCIATES CORP |
$15,673,920 |
55,002 |
0.18% |
株式数
|
| Woodline Partners LP |
$15,406,618 |
54,064 |
0.17% |
株式数
|
| AXA Investment Managers S.A. |
$12,268,948 |
36,011 |
0.14% |
株式数
|
| BARINGS LLC |
$12,200,991 |
42,815 |
0.14% |
株式数
|
| SEB Asset Management AB |
$11,734,757 |
41,179 |
0.13% |
株式数
|
| DIMENSIONAL FUND ADVISORS LP |
$11,412,479 |
40,048 |
0.13% |
株式数
|
| JANE STREET GROUP, LLC |
$10,714,872 |
37,600 |
0.12% |
コールオプション
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$10,563,838 |
37,070 |
0.12% |
株式数
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$10,367,000 |
36,379 |
0.12% |
株式数
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$10,344,411 |
36,300 |
0.12% |
プットオプション
|
| OPPENHEIMER ASSET MANAGEMENT INC. |
$10,196,512 |
35,781 |
0.12% |
株式数
|
| Driehaus Capital Management LLC |
$10,117,575 |
35,504 |
0.11% |
株式数
|
| Atle Fund Management AB |
$10,025,244 |
35,180 |
0.11% |
株式数
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$9,774,471 |
34,300 |
0.11% |
コールオプション
|
| EDMOND DE ROTHSCHILD HOLDING S.A. |
$9,592,090 |
33,660 |
0.11% |
株式数
|
| Fiera Capital Corp |
$9,569,863 |
33,582 |
0.11% |
株式数
|
| ASSETMARK, INC |
$9,232,743 |
32,399 |
0.10% |
株式数
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$8,595,594 |
29,641 |
0.10% |
株式数
|
| AIA Group Ltd |
$8,344,492 |
29,282 |
0.09% |
株式数
|
| Quadrature Capital Ltd |
$8,321,979 |
29,203 |
0.09% |
株式数
|
| Slow Capital, Inc. |
$8,046,698 |
28,237 |
0.09% |
株式数
|
| GEODE CAPITAL MANAGEMENT, LLC |
$7,870,016 |
27,617 |
0.09% |
株式数
|
| Mirae Asset Global Investments Co., Ltd. |
$6,782,001 |
23,799 |
0.08% |
株式数
|
| Capital Group Private Client Services, Inc. |
$6,613,014 |
23,206 |
0.07% |
株式数
|
| Asset Management One Co., Ltd. |
$6,339,122 |
21,346 |
0.07% |
株式数
|
| Trexquant Investment LP |
$5,894,035 |
20,683 |
0.07% |
株式数
|
| Erste Asset Management GmbH |
$5,828,799 |
20,100 |
0.07% |
株式数
|
| BARCLAYS PLC |
$5,760,953 |
20,216 |
0.07% |
株式数
|
| Quantinno Capital Management LP |
$5,646,666 |
19,814 |
0.06% |
株式数
|
| UBS Group AG |
$5,512,460 |
19,344 |
0.06% |
株式数
|
| RAYMOND JAMES FINANCIAL INC |
$5,449,196 |
19,122 |
0.06% |
株式数
|
| CAPITAL GROUP INVESTMENT MANAGEMENT PTE. LTD. |
$4,798,895 |
16,840 |
0.05% |
株式数
|
| Engineers Gate Manager LP |
$4,645,581 |
16,302 |
0.05% |
株式数
|
| Nan Fung Group Holdings Ltd |
$4,480,298 |
15,722 |
0.05% |
株式数
|
| XTX Topco Ltd |
$4,292,788 |
15,064 |
0.05% |
株式数
|
| WELLS FARGO & COMPANY/MN |
$4,197,466 |
14,730 |
0.05% |
株式数
|
| WELLINGTON MANAGEMENT GROUP LLP |
$4,063,387 |
14,259 |
0.05% |
株式数
|
| CITIGROUP INC |
$3,989,580 |
14,000 |
0.05% |
コールオプション
|
| CITIGROUP INC |
$3,989,580 |
14,000 |
0.05% |
プットオプション
|
| MILLENNIUM MANAGEMENT LLC |
$3,562,125 |
12,500 |
0.04% |
プットオプション
|
| MILLENNIUM MANAGEMENT LLC |
$3,562,125 |
12,500 |
0.04% |
コールオプション
|
| CITADEL ADVISORS LLC |
$3,533,628 |
12,400 |
0.04% |
プットオプション
|
| GUGGENHEIM CAPITAL LLC |
$3,519,949 |
12,352 |
0.04% |
株式数
|
| AMERICAN CENTURY COMPANIES INC |
$3,518,240 |
12,346 |
0.04% |
株式数
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$3,497,437 |
12,273 |
0.04% |
株式数
|
| ADAR1 Capital Management, LLC |
$3,334,434 |
11,701 |
0.04% |
株式数
|
| Pinpoint Asset Management (Singapore) Pte. Ltd. |
$3,137,235 |
11,009 |
0.04% |
株式数
|
| NORTHERN TRUST CORP |
$3,131,535 |
10,989 |
0.04% |
株式数
|
| Crossmark Global Holdings, Inc. |
$3,064,852 |
10,755 |
0.03% |
株式数
|
| Bellevue Group AG |
$2,984,776 |
10,474 |
0.03% |
株式数
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$2,792,136 |
9,798 |
0.03% |
株式数
|
| Lansforsakringar Fondforvaltning AB (publ) |
$2,680,317 |
123,352 |
0.03% |
株式数
|
| State of Wyoming |
$2,478,669 |
8,698 |
0.03% |
株式数
|
| CITADEL ADVISORS LLC |
$2,251,263 |
7,900 |
0.03% |
コールオプション
|
| MORGAN STANLEY |
$2,241,326 |
7,865 |
0.03% |
株式数
|
| MACKENZIE FINANCIAL CORP |
$2,218,776 |
7,786 |
0.03% |
株式数
|
| Mitsubishi UFJ Trust & Banking Corp |
$2,158,078 |
7,573 |
0.02% |
株式数
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$2,136,705 |
7,498 |
0.02% |
株式数
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2,126,161 |
7,461 |
0.02% |
株式数
|
| Russell Investments Group, Ltd. |
$2,103,648 |
7,382 |
0.02% |
株式数
|
| STIFEL FINANCIAL CORP |
$2,029,400 |
7,121 |
0.02% |
株式数
|
| JONES FINANCIAL COMPANIES LLLP |
$1,921,445 |
6,865 |
0.02% |
株式数
|
| B. Metzler seel. Sohn & Co. AG |
$1,911,009 |
6,706 |
0.02% |
株式数
|
| NEUBERGER BERMAN GROUP LLC |
$1,861,647 |
6,487 |
0.02% |
株式数
|
| Jefferies Financial Group Inc. |
$1,823,808 |
6,400 |
0.02% |
株式数
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1,813,834 |
6,365 |
0.02% |
株式数
|