IONS Hisse Senedi Özeti Fiyat, piyasa değeri, P/E, EPS, ROE, borç/öz sermaye, 52 haftalık aralık

03

Fiyat $42.93

Piyasa Değeri (MRQ) $7.11B

P/E (TTM) -12.4

Hisse Başına Kâr (TTM) $-3.46

Gelir (TTM) $874M

ROE (TTM) -105.5%

D/E Borç/Özsermaye 3.6

52 Haftlık Aralık $42–$87

IONS Hisse Senedi Fiyat Grafiği Teknik göstergeler ile günlük OHLCV — kaydır, yakınlaştır ve görünümünüzü özelleştirin

04

aralık

çubuklar

Çubuk çözünürlüğü seçilen döneme uyum sağlar — bir çubuk için açılış/yüksek/düşük/kapanış değerlerini görmek için grafiğin üzerine gelin.

10 Yıllık Performans Gelir, net kar, marjlar ve EPS trendleri

06

Gelir·

2016-12-31 → 2017-12-31

Hisse Başına Kâr$-2.38

2016-12-31 → 2025-12-31

Serbest Nakit Akışı$-320M

2016-12-31 → 2025-12-31

Net kar marjı-64.7%

2016-12-31 → 2017-12-31

Değerleme ve Oranlar 07–12

Değerleme P/E, P/S, P/B, EV/EBITDA oranları — hisse senedi pahalı mı ucuz mu?

Metrik	IONS	5Y ort.	Akran Ortalaması	Sonuç
P/E (TTM)	-12.45Y ort. ≈-47.3	≈-47.3	·	·
F/S (TTM)	8.15Y ort. ≈9.0	≈9.0	17.2	Adil değer
F/D (MRQ)	16.25Y ort. ≈13.9	≈13.9	19.3	Aşırı değerli
EV / EBITDA	-16.05Y ort. ≈-17.4	≈-17.4	·	·
Fiyat / Serbest Nakit Akışı (TTM)	-12.75Y ort. ≈27.4	≈27.4	·	·
Fiyat / Nakit Akışı (TTM)	-14.35Y ort. ≈7.4	≈7.4	·	·
EV / Revenue (EV / Gelir)	6.55Y ort. ≈8.7	≈8.7	·	·
EV / FCF	-19.05Y ort. ≈-20.0	≈-20.0	·	·
Price / Tangible Book (Fiyat / Maddi Defter Değeri)	14.35Y ort. ≈14.0	≈14.0	·	·

Akran ortalaması, metrik başına standartlaştırılmış bir temelde hesaplanır ve bu hisse senedi için gösterilen TTM/MRQ temelini her zaman eşleşmeyebilir.

Kârlılık Brüt, faaliyet ve net kâr marjları; ROE, ROA, ROIC

Metrik	IONS	5Y ort.	Akran Ortalaması	Sonuç
Faaliyet Kâr Marjı (TTM)	-68.0%	·	-68.1%	En üst düzey
Vergi Öncesi Kar Marjı (TTM)	-64.3%	·	-58.8%	En üst düzey
Net Kâr Marjı (TTM)	-64.7%	·	-69.2%	En üst düzey
ROA (TTM)	-18.9%5Y ort. ≈-10.3%	≈-10.3%	-32.5%	En üst düzey
ROE (TTM)	-105.5%5Y ort. ≈-57.6%	≈-57.6%	-51.6%	Zayıf
ROIC	-17.1%5Y ort. ≈-19.0%	≈-19.0%	-33.2%	En üst düzey

Finansal Sağlık Borç, likidite, solventlik — bilanço gücü

Metrik	IONS	5Y ort.	Akran Ortalaması	Sonuç
Debt / Equity (Borç / Öz Sermaye)	3.65Y ort. ≈2.7	≈2.7	1.1	Yüksek borç
Cari Oran (MRQ)	7.95Y ort. ≈7.0	≈7.0	5.1	Güçlü likidite
Quick Ratio (Cari Oran)	3.45Y ort. ≈5.2	≈5.2	3.3	Güçlü likidite
Long-Term Debt / Equity (Uzun Vadeli Borç / Özkaynak)	2.75Y ort. ≈2.5	≈2.5	·	·
Interest Coverage (Faiz Karşılama Oranı)	-22.15Y ort. ≈-26.3	≈-26.3	-17.7	Düşük likidite

Hisse Başı Metrikler Hisse Başı Kâr, hisse başına defter değeri, hisse başına nakit akışı, hisse başına temettü

Metrik	IONS	5Y ort.	Akran Ortalaması	Sonuç
EPS (Diluted) (Hisse Başına Kar (Seyreltilmiş))	$-2.385Y ort. ≈$-2.02	≈$-2.02	·	·
Cash Flow / Share (Hisse Başına Nakit Akışı)	$-1.685Y ort. ≈$-1.78	≈$-1.78	·	·
Cash / Share (Hisse Başına Nakit)	$2.285Y ort. ≈$2.94	≈$2.94	·	·

Sermaye Verimliliği Aktif devir hızı, stok devir hızı, alacak devir hızı

Metrik	5 Yıllık trend	IONS	5Y ort.	Akran Ortalaması	Sonuç
Inventory Turnover (Stok Devir Hızı)		1.45Y ort. ≈0.8	≈0.8	1.1	En üst düzey

değer · ≈ 5Y ort. · sektör ortalaması · ortalamaya göre değerlendirme

Kazanç Geçmişi EPS gerçekleşen vs tahmin, sürpriz %, kazanma oranı, bir sonraki kazanç tarihi

14

Ort. Sürpriz 64.3%

Sonraki Rapor Eki 27, 2026

Dönem	Rapor	EPS Gerçek	EPS Tahmin	Sürpriz
30 Haziran 2026	Tem 28, 2026	$-0.69	$-1.09	36.7%
31 Mart 2026		$-0.56	$-0.93	39.7%
31 Aralık 2025		$-1.41	$-1.35	-4.6%
30 Eylül 2025		$-0.80	$-1.26	36.4%
30 Haziran 2025		$0.70	$-0.44	259.6%
31 Mart 2025		$-0.93	$-1.14	18.4%

Tüm Temeller Tüm metrikler yıla göre — gelir tablosu, bilanço, nakit akışı

15

Gelir Tablosu 16

Metrik	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Revenue	·	·	·	·	·	·	·	·	$508M	$347M	$284M	$214M
Cost of Revenue	$16M	$11M	$9M	$14M	$11M	$12M	$4M	$2M	$0	$0	·	·
R&D Expense	$916M	$902M	$900M	·	$638M	$531M	$462M	$412M	$372M	$340M	$320M	$239M
SG&A Expense	$394M	$267M	$233M	$150M	$186M	$354M	$287M	$245M	$108M	$49M	$37M	$20M
Operating Expenses	$1.33B	$1.18B	$1.14B	$998M	$841M	$901M	$757M	$661M	$483M	$393M	$359M	$262M
Operating Income	$-382M	$-475M	$-354M	$-410M	$-30M	$-172M	$366M	$-61M	$31M	$-20M	$-76M	$-48M
Interest Expense	$17M	$17M	$13M	$8M	$9M	$10M	$12M	$45M	$45M	$39M	$37M	$22M
Other Non-op	$-15M	$1M	$14M	$-7M	$-10M	$-62.0K	$-686.0K	$-182.0K	$-4M	$0	·	·
Pretax Income	$-380M	$-460M	$-334M	$-258M	$-29M	$-135M	$339M	$-76M	$-17M	$-57M	$-88M	$-54M
Income Tax	$2M	$-6M	$32M	$12M	$-551.0K	$345M	$52M	$-291M	$-6M	$3M	$372.0K	$-15M
Net Income	$-381M	$-454M	$-366M	$-270M	$-29M	$-444M	$278M	$274M	$346.0K	$-60M	$-88M	$-39M
EPS (Basic)	$-2.38	$-3.04	$-2.56	$-1.90	$-0.20	$-3.18	$2.00	$2.09	$0.15	$-0.50	$-0.74	·
EPS (Diluted)	$-2.38	$-3.04	$-2.56	$-1.90	$-0.20	$-3.18	$1.90	$2.07	$0.15	$-0.50	$-0.74	·
Shares (Basic)	160,010,000	149,514,000	143,190,000	141,848,000	141,021,000	139,612,000	139,998,000	132,320,000	124,016,000	120,933,000	119,719,000	·
Shares (Diluted)	160,010,000	149,514,000	143,190,000	141,848,000	141,021,000	139,612,000	153,164,000	134,056,000	126,098,000	120,933,000	119,719,000	·
EBITDA	$-382M	$-475M	$-354M	$-410M	$-30M	$-172M	$366M	$-61M	$25M	$-46M	$-76M	$-48M

Bilanço 24

Metrik	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Cash & Equivalents	$372M	$242M	$399M	$276M	$869M	$398M	$683M	$279M	$130M	$85M	$129M	$143M
Short-term Investments	$2.31B	$2.06B	$1.93B	$1.71B	$1.25B	·	·	·	·	·	·	·
Inventory	$10M	$13M	$7M	$22M	$25M	$22M	$18M	$9M	$10M	·	·	·
Other Current Assets	$237M	$218M	$205M	$168M	$143M	$140M	$140M	$102M	$73M	$17M	$15M	$16M
Current Assets	$2.99B	$2.62B	$2.64B	$2.20B	$2.35B	$2.13B	$2.72B	$2.21B	$1.17B	$798M	$837M	$837M
PP&E (Net)	$123M	$94M	$71M	$74M	$178M	$181M	$154M	$132M	$122M	$93M	$90M	$89M
Accum. Depreciation	$109M	$106M	$97M	$88M	$103M	$87M	$74M	$61M	$88M	$80M	$73M	$66M
Intangibles	·	·	·	·	$29M	$28M	$26M	$24M	$22M	$20M	·	·
Other Non-current Assets	$172M	$127M	$105M	$75M	$71M	$50M	$28M	$13M	$10M	$1M	·	·
Total Assets	$3.52B	$3.00B	$2.99B	$2.53B	$2.61B	$2.39B	$3.23B	$2.67B	$1.32B	$912M	$948M	$956M
Accounts Payable	$28M	$43M	$26M	$18M	$12M	$17M	$16M	$29M	$25M	$21M	$28M	$18M
Accrued Liabilities	$106M	$108M	$148M	$140M	$89M	$90M	$67M	$48M	$67M	$36M	$28M	$30M
Current Liabilities	$782M	$309M	$448M	$312M	$241M	$599M	$273M	$280M	$244M	$134M	$149M	$115M
Capital Leases	$262M	$162M	$171M	$179M	$19M	·	·	·	·	·	·	·
Other Non-current Liabilities	$28M	$52M	$42M	$16M	$7M	·	·	·	·	·	·	·
Total Liabilities	$3.03B	$2.42B	$2.60B	$1.96B	$1.84B	$1.65B	$1.55B	$1.48B	$957M	$813M	$747M	$698M
Long-term Debt	$1.81B	$1.25B	$1.31B	$1.19B	·	·	·	·	·	·	·	·
Total Debt	$1.76B	$1.20B	$1.24B	$1.18B	·	·	·	·	·	·	·	·
Common Stock	$163.0K	$158.0K	$144.0K	$142.0K	$141.0K	$140.0K	$140.0K	$138.0K	$125.0K	$122.0K	$120.0K	$118.0K
Retained Earnings	$-2.63B	$-2.25B	$-1.80B	$-1.43B	$-1.16B	$-1.13B	$-708M	$-967M	$-1.24B	$-1.18B	$-1.09B	$-1.01B
AOCI	$-25M	$-31M	$-33M	$-57M	$-33M	$-21M	$-25M	$-32M	$-32M	$-30M	$-14M	$40M
Stockholders' Equity	$489M	$588M	$387M	$573M	$772M	$743M	$1.47B	$1.05B	$281M	$100M	$201M	$258M
Liabilities + Equity	$3.52B	$3.00B	$2.99B	$2.53B	$2.61B	$2.39B	$3.23B	$2.67B	$1.32B	$912M	$948M	$956M
Shares Outstanding	163,304,875	157,908,815	144,340,526	142,057,736	141,210,015	140,365,594	140,339,615	137,928,828	124,976,373	121,636,273	120,351,480	118,442,726

Nakit Akışı 14

Metrik	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Stock-based Comp	$134M	$130M	$106M	$100M	$121M	$230M	$147M	$131M	$86M	$72M	$59M	$31M
Deferred Tax	$0	$0	$0	$0	$0	$342M	$904.0K	$-291M	$0	$0	$0	$-11M
Amort. of Intangibles	$2M	$2M	$3M	$2M	$2M	$2M	$2M	$2M	$2M	$2M	·	·
Operating Cash Flow	$-269M	$-501M	$-308M	$-274M	$31M	$36M	$346M	$603M	$174M	$-112M	$21M	$6M
CapEx	$51M	$45M	$24M	$16M	$12M	$35M	$31M	$14M	$35M	$7M	$8M	$8M
Investing Cash Flow	$-278M	$-134M	$-214M	$-263M	$195M	$274M	$-41M	$-930M	$-358M	$57M	$-60M	·
Stock Issued	$0	$489M	$0	$0	·	$0	$0	$448M	$72M	$0	$0	$0
Stock Repurchased	·	·	·	$0	$0	$91M	$34M	$0	$0	·	·	·
Net Stock Activity	$0	$489M	·	$0	$0	$-91M	$-34M	·	$72M	·	$0	$0
Financing Cash Flow	$676M	$478M	$644M	$-55M	$246M	$-597M	$100M	$476M	$229M	$11M	$25M	·
Net Change in Cash	$130M	$-157M	$123M	$-593M	$472M	$-286M	$404M	$149M	$45M	$-44M	$-14M	·
Taxes Paid	$-639.0K	$-6M	$48M	$5M	·	$26M	$9M	$0	$0	·	·	·
Free Cash Flow	$-320M	$-546M	$-331M	$-290M	$19M	$772.0K	$315M	$589M	$139M	$-119M	$13M	$-1M
Levered FCF	$-337M	$-563M	$-345M	$-299M	$10M	$-128M	$272M	$716M	$106M	$-159M	$-23M	$-17M

Kârlılık 7

Metrik	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Operating Margin	·	·	·	·	·	·	·	·	4.8%	-13.4%	-26.7%	-22.3%
Net Margin	·	·	·	·	·	·	·	·	-1.2%	-25.0%	-31.1%	-18.2%
Pretax Margin	·	·	·	·	·	·	·	·	-4.6%	-24.1%	-31.0%	-25.4%
EBITDA Margin	·	·	·	·	·	·	·	·	4.8%	-13.4%	-26.7%	-22.3%
ROA	-11.7%	-15.2%	-13.3%	-10.5%	-1.1%	-16.1%	10.0%	13.7%	-0.53%	-9.3%	-9.2%	-4.3%
ROE	-68.1%	-71.9%	-104.3%	-40.1%	-3.8%	-39.0%	23.4%	41.2%	-2.8%	-57.6%	-38.5%	-12.3%
ROIC	-17.1%	-26.0%	-23.8%	-24.5%	-3.8%	-58.4%	21.8%	16.5%	5.5%	-48.1%	-37.9%	-13.3%

Likidite ve Solventlik 5

Metrik	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Current Ratio	3.8	8.5	5.9	7.1	9.7	3.7	10.0	7.9	5.2	6.0	5.6	7.3
Quick Ratio	3.4	7.4	5.2	6.4	3.6	0.7	2.5	1.0	0.6	0.6	0.9	1.2
Debt / Equity	3.6	2.0	3.2	2.1	·	·	·	·	·	·	·	·
LT Debt / Equity	2.7	2.0	3.2	2.1	·	·	·	·	·	·	·	·
Interest Coverage	-22.1	-28.0	-27.9	-50.5	-3.2	-3.8	7.5	-1.4	0.5	-1.2	-2.1	-2.1

Verimlilik 2

Metrik	Eğilim	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Asset Turnover		·	·	·	·	·	·	·	·	0.5	0.4	0.3	0.2
Inventory Turnover		1.4	1.1	0.4	0.6	0.5	0.6	0.3	0.2	·	·	·	·

Hisse Başına 5

Metrik	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Book Value / Share	$2.99	$3.80	$2.68	$4.03	$5.47	$6.01	$10.48	$7.60	$2.65	$0.82	$1.67	$2.18
Revenue / Share	·	·	·	·	·	·	·	·	$4.03	·	·	·
Cash Flow / Share	$-1.68	$-3.35	$-2.15	$-1.93	$0.22	$0.26	$2.42	$4.50	$1.38	·	·	·
Cash / Share	$2.28	$1.53	$2.77	$1.95	$6.16	$2.83	$4.87	$2.02	$1.04	$0.70	$1.07	$1.21
EPS (TTM)	$-2.38	$-3.04	$-2.56	$-1.90	$-0.20	$-3.18	$1.90	$2.07	$0.15	$-0.50	$-0.74	$-0.35

Değerleme (TTM) 14

Metrik	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Revenue TTM	$944M	$705M	$788M	$587M	$810M	$729M	$1.12B	$600M	$508M	$347M	$284M	$214M
Net Income TTM	$-381M	$-454M	$-366M	$-270M	$-29M	$-444M	$278M	$274M	$346.0K	$-60M	$-88M	$-39M
Market Cap	$12.92B	$5.52B	$7.30B	$5.37B	$4.30B	$7.94B	$8.48B	$7.46B	$6.29B	$5.82B	$7.45B	$7.31B
Enterprise Value	$12.00B	$4.43B	$6.21B	$4.55B	·	·	·	·	·	·	·	·
P/E	-33.2	-11.5	-19.8	-19.9	-152.2	-17.8	31.8	26.1	335.3	-95.7	-83.7	-176.4
P/S	13.7	7.8	9.3	9.1	5.3	10.9	7.6	12.4	12.4	16.8	26.3	34.1
P/B	26.4	9.2	18.9	9.4	5.6	9.4	5.8	7.1	19.0	58.4	37.1	28.4
P / Tangible Book	26.4	9.4	18.9	9.4	5.8	11.1	·	·	·	·	·	·
P / Cash Flow	-48.1	-11.0	-23.7	-19.6	139.5	221.1	24.5	12.4	36.1	-51.9	352.8	1163.5
P / FCF	-40.4	-10.1	-22.0	-18.5	228.0	10280.1	26.9	12.7	45.1	-48.8	554.9	-5930.8
EV / EBITDA	-31.4	-9.3	-17.6	-11.1	·	·	·	·	·	·	·	·
EV / FCF	-37.5	-8.1	-18.7	-15.7	·	·	·	·	·	·	·	·
EV / Revenue	12.7	6.3	7.9	7.8	·	·	·	·	·	·	·	·
Earnings Yield	-3.0%	-8.7%	-5.1%	-5.0%	-0.66%	-5.6%	3.1%	3.8%	0.30%	-1.1%	-1.2%	-0.57%

Gelir Tablosu 15

Metrik	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue	$268M	$246M	$203M	$157M	$452M	$132M	$227M	$134M	$225M	$119M	$325M	$144M	$188M	$131M	$152M	$160M
Cost of Revenue	$3M	$3M	$8M	$2M	$4M	$1M	$4M	$1M	$4M	$2M	$3M	$2M	$3M	$1M	$4M	$2M
SG&A Expense	$150M	$150M	$130M	$97M	$91M	$76M	$88M	$62M	$65M	$53M	$71M	$70M	$46M	$46M	$48M	$34M
Operating Expenses	$370M	$364M	$418M	$317M	$312M	$278M	$337M	$282M	$291M	$269M	$331M	$287M	$279M	$245M	$360M	$219M
Operating Income	$-102M	$-117M	$-214M	$-160M	$140M	$-147M	$-111M	$-149M	$-66M	$-150M	$-6M	$-143M	$-90M	$-114M	$-208M	$-59M
Interest Expense	$5M	$5M	$5M	$4M	$4M	$4M	$4M	$4M	$4M	$4M	$5M	$4M	$2M	$2M	$2M	$2M
Other Non-op	$987.0K	$-456.0K	$-16M	$363.0K	$102.0K	$465.0K	$302.0K	$142.0K	$610.0K	$277.0K	$235.0K	$2M	$11M	$230.0K	$123.0K	$5M
Pretax Income	$-113M	$-92M	$-228M	$-128M	$124M	$-147M	$-107M	$-144M	$-66M	$-143M	$-3M	$-141M	$-77M	$-113M	$-44M	$-47M
Income Tax	$1M	$218.0K	$1M	$213.0K	$-20.0K	$116.0K	$-3M	$-4M	$64.0K	$75.0K	$6M	$7M	$8M	$11M	$8M	$283.0K
Net Income	$-115M	$-93M	$-229M	$-129M	$124M	$-147M	$-104M	$-140M	$-66M	$-143M	$-9M	$-147M	$-85M	$-124M	$-52M	$-47M
EPS (Basic)	$-0.69	$-0.56	$-1.41	$-0.80	$0.78	$-0.93	$-0.66	$-0.95	$-0.45	$-0.98	$-0.06	$-1.03	$-0.60	$-0.87	$-0.37	$-0.33
EPS (Diluted)	$-0.69	$-0.56	$-1.41	$-0.80	$0.70	$-0.93	$-0.66	$-0.95	$-0.45	$-0.98	$-0.06	$-1.03	$-0.60	$-0.87	$-0.37	$-0.33
Shares (Basic)	165,419,000	164,874,000	·	159,765,000	159,137,000	158,735,000	·	148,593,000	145,958,000	145,538,000	·	143,317,000	143,098,000	142,735,000	·	141,950,000
Shares (Diluted)	165,419,000	164,874,000	·	159,765,000	182,331,000	158,735,000	·	148,593,000	145,958,000	145,538,000	·	143,317,000	143,098,000	142,735,000	·	141,950,000
EBITDA	$-102M	$-117M	·	$-160M	$140M	$-147M	·	$-149M	$-66M	$-150M	·	$-143M	$-90M	$-114M	·	$-59M

Bilanço 23

Metrik	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Cash & Equivalents	$350M	$173M	$372M	$338M	$297M	$264M	$242M	$335M	$294M	$349M	·	$352M	$425M	$309M	·	$315M
Short-term Investments	$1.70B	$1.75B	$2.31B	$1.90B	$1.99B	$1.88B	$2.06B	$2.15B	$1.78B	$1.86B	·	$1.88B	$1.96B	$2.04B	·	$1.67B
Inventory	$51M	$6M	$10M	$10M	$8M	$12M	$13M	$28M	$29M	$30M	·	$26M	$26M	$22M	·	$21M
Other Current Assets	$327M	$306M	$237M	$244M	$226M	$223M	$218M	$184M	$195M	$174M	·	$181M	$178M	$160M	·	$143M
Current Assets	$2.49B	$2.94B	$2.99B	$2.52B	$2.58B	$2.42B	$2.62B	$2.71B	$2.33B	$2.42B	·	$2.58B	$2.62B	$2.54B	·	$2.15B
PP&E (Net)	$155M	$142M	$123M	$106M	$112M	$103M	$94M	$83M	$76M	$73M	·	$71M	$92M	$85M	·	$181M
Accum. Depreciation	·	·	$109M	·	·	·	$106M	·	·	·	·	·	·	·	·	·
Intangibles	·	·	·	·	·	·	·	·	·	·	·	·	·	·	·	$30M
Other Non-current Assets	$117M	$136M	$172M	$166M	$132M	$132M	$127M	$120M	$119M	$106M	·	$104M	$86M	$78M	·	$59M
Total Assets	$2.99B	$3.45B	$3.52B	$3.03B	$2.99B	$2.81B	$3.00B	$3.08B	$2.69B	$2.76B	·	$2.93B	$2.97B	$2.89B	·	$2.42B
Accounts Payable	$48M	$26M	$28M	$14M	$23M	$17M	$43M	$9M	$9M	$13M	·	$6M	$24M	$10M	·	$21M
Accrued Liabilities	$116M	$127M	$106M	$99M	$99M	$103M	$108M	$124M	$114M	$106M	·	$119M	$105M	$113M	·	$128M
Current Liabilities	$316M	$717M	$782M	$903M	$897M	$250M	$309M	$305M	$306M	$328M	·	$404M	$288M	$259M	·	$283M
Capital Leases	$262M	$259M	$262M	$263M	$164M	$159M	$162M	$168M	$166M	$169M	·	$173M	$175M	$177M	·	·
Other Non-current Liabilities	$28M	$28M	·	$29M	$59M	$56M	·	$42M	$42M	$42M	·	$49M	$16M	$7M	·	·
Total Liabilities	$2.55B	$2.96B	$3.03B	$2.42B	$2.35B	$2.34B	$2.42B	$2.42B	$2.43B	$2.47B	·	$2.62B	$2.54B	$2.40B	·	$1.83B
Long-term Debt	·	·	$1.81B	·	·	·	·	·	·	·	·	·	·	·	·	·
Common Stock	$166.0K	$166.0K	$163.0K	$161.0K	$159.0K	$159.0K	$158.0K	$158.0K	$146.0K	$146.0K	·	$143.0K	$143.0K	$143.0K	·	$142.0K
Retained Earnings	$-2.84B	$-2.72B	$-2.63B	$-2.40B	$-2.27B	$-2.40B	$-2.25B	$-2.15B	$-2.00B	$-1.94B	·	$-1.79B	$-1.64B	$-1.55B	·	$-1.38B
AOCI	$-34M	$-31M	$-25M	$-26M	$-28M	$-29M	$-31M	$-24M	$-35M	$-35M	·	$-46M	$-51M	$-49M	·	$-63M
Stockholders' Equity	$440M	$491M	$489M	$618M	$632M	$476M	$588M	$662M	$264M	$297M	$387M	$315M	$428M	$487M	$573M	$594M
Liabilities + Equity	$2.99B	$3.45B	$3.52B	$3.03B	$2.99B	$2.81B	$3.00B	$3.08B	$2.69B	$2.76B	·	$2.93B	$2.97B	$2.89B	·	$2.42B
Shares Outstanding	165,636,792	165,902,064	163,304,875	161,137,930	159,196,782	159,041,259	157,908,815	157,813,136	146,025,246	145,844,719	·	143,393,493	143,167,414	143,022,539	·	142,017,411

Nakit Akışı 11

Metrik	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Stock-based Comp	$46M	$43M	$43M	$31M	$30M	$30M	$36M	$32M	$31M	$31M	$26M	$26M	$27M	$27M	$26M	$24M
Amort. of Intangibles	$700.0K	$661.0K	$638.0K	$621.0K	$598.0K	$582.0K	$459.0K	$617.0K	$621.0K	$639.0K	$655.0K	$660.0K	$637.0K	$607.0K	$610.0K	$608.0K
Operating Cash Flow	$566M	$-793M	$-138M	$-131M	$151M	$-151M	$-116M	$-115M	$-120M	$-150M	$33M	$-109M	$-97M	$-134M	$-200M	$-24M
CapEx	$16M	$22M	$21M	$5M	$12M	$13M	$25M	$9M	$6M	$4M	$-819.0K	$2M	$12M	$10M	$4M	$6M
Investing Cash Flow	$23M	$537M	$-420M	$91M	$-120M	$170M	$68M	$-341M	$62M	$76M	$-27M	$69M	$70M	$-326M	$212M	$-184M
Stock Issued	·	·	$0	·	·	·	$27.0K	·	·	·	$0	·	·	·	·	·
Financing Cash Flow	$-412M	$57M	$591M	$81M	$1M	$2M	$-44M	$496M	$3M	$24M	$41M	$-32M	$144M	$492M	$-51M	$2M
Net Change in Cash	$177M	$-199M	$34M	$41M	$33M	$22M	$-93M	$41M	$-55M	$-50M	$47M	$-73M	$116M	$33M	$-39M	$-207M
Taxes Paid	$1M	$-8.0K	$22.0K	$-278.0K	$17.0K	$-400.0K	$-8M	$80.0K	$2M	$13.0K	·	·	·	·	·	·
Free Cash Flow	·	$-815M	·	·	·	$-163M	·	·	·	$-154M	·	·	·	$-144M	·	·
Levered FCF	·	$-820M	·	·	·	$-167M	·	·	·	$-159M	·	·	·	$-146M	·	·

Kârlılık 7

Metrik	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Operating Margin	-38.2%	-47.7%	·	-102.2%	30.9%	-111.6%	·	-111.1%	-29.3%	-125.1%	·	-99.4%	-47.9%	-87.5%	·	-37.0%
Net Margin	-42.8%	-37.6%	·	-82.1%	27.3%	-111.6%	·	-105.0%	-29.4%	-119.5%	·	-102.2%	-45.3%	-95.2%	·	-29.4%
Pretax Margin	-42.3%	-37.5%	·	-81.9%	27.3%	-111.6%	·	-107.7%	-29.4%	-119.4%	·	-97.6%	-41.1%	-86.5%	·	-29.2%
EBITDA Margin	-38.2%	-47.7%	·	-102.2%	30.9%	-111.6%	·	-111.1%	-29.3%	-125.1%	·	-99.4%	-47.9%	-87.5%	·	-37.0%
ROA	-3.8%	-2.9%	·	-4.2%	4.3%	-5.3%	·	-4.7%	-2.3%	-5.1%	·	-5.5%	-3.1%	-4.6%	·	-1.9%
ROE	-21.4%	-19.1%	·	-20.1%	27.6%	-38.0%	·	-28.7%	-19.1%	-36.5%	·	-32.4%	-16.2%	-20.8%	·	-8.3%
ROIC	-23.5%	-23.9%	·	-26.0%	22.1%	-30.9%	·	-21.9%	-25.1%	-50.4%	·	-47.5%	-23.2%	-25.8%	·	-10.0%

Likidite ve Solventlik 3

Metrik	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Current Ratio	7.9	4.1	·	2.8	2.9	9.7	·	8.9	7.6	7.4	·	6.4	9.1	9.8	·	7.6
Quick Ratio	6.5	2.7	·	2.5	2.6	8.6	·	8.2	6.8	6.7	·	5.5	8.3	9.1	·	7.0
Interest Coverage	-22.2	-22.8	·	-38.0	34.0	-35.7	·	-35.7	-14.7	-36.0	·	-34.1	-39.4	-71.0	·	-27.7

Verimlilik 2

Metrik	Eğilim	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Asset Turnover		0.1	0.1	·	0.1	0.2	0.0	·	0.0	0.1	0.0	·	0.1	0.1	0.0	·	0.1
Inventory Turnover		0.1	0.3	·	0.1	0.2	0.1	·	0.0	0.2	0.1	·	0.1	0.1	0.1	·	0.1

Hisse Başına 5

Metrik	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Book Value / Share	$2.65	$2.96	·	$3.83	$3.97	$2.99	·	$4.20	$1.81	$2.03	·	$2.20	$2.99	$3.40	·	$4.19
Revenue / Share	$1.62	$1.49	·	$0.98	$2.48	$0.83	·	$0.90	$1.54	$0.82	·	$1.01	$1.32	$0.91	·	$1.13
Cash Flow / Share	·	$-4.81	·	·	·	$-0.95	·	·	·	$-1.03	·	·	·	$-0.94	·	·
Cash / Share	$2.11	$1.05	·	$2.10	$1.87	$1.66	·	$2.12	$2.01	$2.39	·	$2.46	$2.97	$2.16	·	$2.22
EPS (TTM)	$-3.46	$-2.07	·	$-1.69	$-1.84	$-2.99	·	$-2.44	$-2.52	$-2.67	·	$-2.87	$-2.17	$-2.31	·	$0.06

Değerleme (TTM) 9

Metrik	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue TTM	$874M	$1.06B	·	$967M	$944M	$717M	·	$803M	$813M	$777M	·	$615M	$631M	$576M	·	$875M
Net Income TTM	$-565M	$-327M	·	$-256M	$-268M	$-458M	·	$-359M	$-366M	$-385M	·	$-409M	$-309M	$-329M	·	$7M
Market Cap	$13.13B	$12.46B	·	$10.54B	$6.29B	$4.80B	·	$6.32B	$6.96B	$6.32B	·	$6.50B	$5.87B	$5.11B	·	$6.28B
P/E	-22.9	-36.3	·	-38.7	-21.5	-10.1	·	-16.4	-18.9	-16.2	·	-15.8	-18.9	-15.5	·	737.2
P/S	15.0	11.8	·	10.9	6.7	6.7	·	7.9	8.6	8.1	·	10.6	9.3	8.9	·	7.2
P/B	29.9	25.4	·	17.1	10.0	10.1	·	9.5	26.4	21.3	·	20.6	13.7	10.5	·	10.6
P / Tangible Book	29.9	25.4	·	17.1	10.0	10.1	·	9.5	26.4	21.3	·	20.6	13.7	10.5	·	11.1
P / Cash Flow	·	-15.7	·	·	·	-31.8	·	·	·	-42.2	·	·	·	-38.1	·	·
Earnings Yield	-4.4%	-2.8%	·	-2.6%	-4.7%	-9.9%	·	-6.1%	-5.3%	-6.2%	·	-6.3%	-5.3%	-6.5%	·	0.14%

En son dönem solda · null değerler · olarak gösterilir

Finansal Tablolar Gelir tablosu, bilanço, nakit akışı — yıllık, son 5 yıl

16

Metrik	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Net Gelir	$-381M	$-454M	$-366M	$-270M	$-29M
Seyreltilmiş Hisse Başı Kâr	$-2.38	$-3.04	$-2.56	$-1.90	$-0.20

Metrik	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Borç / Öz Sermaye	3.6	2.0	3.2	2.1	·
Cari Oran	3.8	8.5	5.9	7.1	9.7
Cari Oran	3.4	7.4	5.2	6.4	3.6

Metrik	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Serbest Nakit Akışı	$-320M	$-546M	$-331M	$-290M	$19M

Kurumsal Sahipler (13F) 554 dosya · $15.6B toplam · Tarih itibarıyla 30 Eylül 2026

17

Çeyreklik SEC Form 13F'lerinde bu hisse senedini tuttuklarını bildiren kurumlar. Yalnızca uzun pozisyonlar; tek bir başvuru sahibi, ayrı opsiyon bacakları için iki kez görünebilir. Büyük dengeleyici alım/satım bacakları genellikle piyasa yapımını veya korunmuş envanteri yansıtır, yönlü bir inancı değil.

Sahipler 554

Tutulan Değer $15.6B

Yeni pozisyonlar 75

Çıkan pozisyonlar 41

Kurumsal faaliyet — Q2 2026 ve önceki çeyrek

Yeni pozisyonlar	Çıkan pozisyonlar	Artırıldı	Azaldı	Net hisse senedi değişimi
75 (-17 önceki Ç'ye göre)	41 (-24 önceki Ç'ye göre)	213 (+26 önceki Ç'ye göre)	159 (+3 önceki Ç'ye göre)	+10.5M

Q1 2026 ile karşılaştırıldı. SEC Form 13F başvuruları, çeyrek sonundan itibaren 45 gün içinde ve geç başvuranlar için kısa bir ek süre içinde tamamlanmalıdır — bu pencere içindeki çeyrekler, en son tam olarak raporlanan çifte tercih edilerek atlanır.

Kurum	Değer	Hisse senetleri	% izlenen 13F'nin	Tür
FMR LLC	$1.953.067.764	24.631.956	12,51%	Hisse senetleri
Capital World Investors	$1.718.152.930	21.669.226	11,01%	Hisse senetleri
VANGUARD GROUP INC	$1.300.604.712	16.440.459	8,33%	Hisse senetleri
BlackRock, Inc.	$848.772.532	10.704.660	5,44%	Hisse senetleri
VANGUARD PORTFOLIO MANAGEMENT LLC	$623.182.054	7.859.529	3,99%	Hisse senetleri
WELLINGTON MANAGEMENT GROUP LLP	$606.680.694	7.651.415	3,89%	Hisse senetleri
VANGUARD CAPITAL MANAGEMENT LLC	$571.799.597	7.211.497	3,66%	Hisse senetleri
TWO SIGMA INVESTMENTS, LP	$495.748.197	6.252.342	3,18%	Hisse senetleri
ROYAL BANK OF CANADA	$490.209.000	6.182.479	3,14%	Hisse senetleri
STATE STREET CORP	$343.710.098	4.334.848	2,20%	Hisse senetleri
GEODE CAPITAL MANAGEMENT, LLC	$294.752.810	3.584.024	1,89%	Hisse senetleri
TWO SIGMA ADVISERS, LP	$241.452.501	3.052.111	1,55%	Hisse senetleri
JPMORGAN CHASE & CO	$216.198.792	2.671.717	1,39%	Hisse senetleri
Artisan Partners Limited Partnership	$209.327.536	2.640.024	1,34%	Hisse senetleri
Tweedy, Browne Co LLC	$180.805.859	2.280.311	1,16%	Hisse senetleri
Deep Track Capital, LP	$174.438.000	2.200.000	1,12%	Hisse senetleri
GOLDMAN SACHS GROUP INC	$167.297.540	2.109.945	1,07%	Hisse senetleri
BAKER BROS. ADVISORS LP	$162.364.274	2.047.727	1,04%	Hisse senetleri
DEERFIELD MANAGEMENT COMPANY, L.P.	$156.967.955	1.979.669	1,01%	Hisse senetleri
AMERICAN CENTURY COMPANIES INC	$154.383.816	1.947.076	0,99%	Hisse senetleri
FRANKLIN RESOURCES INC	$128.717.601	1.623.377	0,82%	Hisse senetleri
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	$127.264.731	1.605.054	0,82%	Hisse senetleri
BARCLAYS PLC	$127.112.653	1.603.136	0,81%	Hisse senetleri
Pictet Asset Management Holding SA	$126.981.913	1.596.998	0,81%	Hisse senetleri
Polar Capital Holdings Plc	$115.289.325	1.454.021	0,74%	Hisse senetleri
Alyeska Investment Group, L.P.	$112.426.560	1.417.916	0,72%	Hisse senetleri
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	$110.805.207	1.475.632	0,71%	Hisse senetleri
SUSQUEHANNA INTERNATIONAL GROUP, LLP	$103.108.716	1.300.400	0,66%	Alım opsiyonu
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	$103.108.000	1.300.392	0,66%	Hisse senetleri
MORGAN STANLEY	$101.605.768	1.281.444	0,65%	Hisse senetleri
Invesco Ltd.	$88.860.858	1.120.707	0,57%	Hisse senetleri
VANGUARD FIDUCIARY TRUST CO	$84.114.400	1.060.845	0,54%	Hisse senetleri
Bellevue Group AG	$77.090.336	972.258	0,49%	Hisse senetleri
GROUPAMA ASSET MANAGMENT	$75.195.315	937.083	0,48%	Hisse senetleri
NORTHERN TRUST CORP	$72.440.137	913.610	0,46%	Hisse senetleri
Capital International Investors	$65.316.248	823.764	0,42%	Hisse senetleri
SUSQUEHANNA INTERNATIONAL GROUP, LLP	$65.184.309	822.100	0,42%	Satım opsiyonu
Davern Capital Partners, LP	$63.329.637	798.709	0,41%	Hisse senetleri
BANK OF AMERICA CORP /DE/	$62.717.591	790.990	0,40%	Hisse senetleri
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC	$62.422.083	787.263	0,40%	Hisse senetleri
BNP PARIBAS ASSET MANAGEMENT Holding S.A.	$58.216.225	734.219	0,37%	Hisse senetleri
Nuveen, LLC	$57.586.900	726.282	0,37%	Hisse senetleri
Connor, Clark & Lunn Investment Management Ltd.	$54.253.072	684.236	0,35%	Hisse senetleri
Eversept Partners, LP	$52.702.794	664.684	0,34%	Hisse senetleri
VOLORIDGE INVESTMENT MANAGEMENT, LLC	$51.970.948	655.454	0,33%	Hisse senetleri
MASSACHUSETTS FINANCIAL SERVICES CO /MA/	$51.682.490	651.816	0,33%	Hisse senetleri
NEUBERGER BERMAN GROUP LLC	$50.232.832	633.533	0,32%	Hisse senetleri
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	$50.113.500	632.028	0,32%	Hisse senetleri
Caption Management, LLC	$49.952.700	630.000	0,32%	Alım opsiyonu
UBS Group AG	$49.546.260	624.874	0,32%	Hisse senetleri

Tüm 554 kurumsal sahibi göster →

Aktivistler ve %5+ sahipler 5 pozisyon

18

SEC Çizelge 13D dosyalayan yatırımcılar — ihraççı üzerinde nüfuz etme niyetiyle %5'in üzerinde faydalı sahiplik (aktivist hisseler, yönetim kurulu kampanyaları, M&A). Her satır, o başvuru sahibinin pozisyonunun bilinen en son durumunu gösterir.

Başvuru sahibi	Dosyalandı	Hisse	Durum	Amaç	Başvuru
Ionis Pharmaceuticals, Inc. (“Ionis”) ×8 başvurular	13 Ekim 2020	·	İlk başvuru	M&A / satış	SEC
Isis Pharmaceuticals, Inc. (“ Isis ”)	31 Temmuz 2015	·	İlk başvuru	·	SEC
Isis Pharmaceuticals, Inc. (“Isis”), Stanley T. Crooke (“Crooke”), B. Lynne Parshall (“Parshall”) ×2 başvurular	06 Kasım 2014	·	İlk başvuru	·	SEC
Genzyme Corporation	15 Ocak 2008	·	İlk başvuru	Pasif yatırım	SEC
Açıklanmayan raporlama kişisi	12 Nisan 2001	·	İlk başvuru	Pasif yatırım	SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Şirket yöneticileri 47 içeriden öğrenenler · 30 yöneticiler · 19 yönetim kurulu üyeleri

19

İçeriden Öğrenen	Rol	Son işlem	Sahip olunan hisse senetleri	Alımlar 12ay	Satışlar 12ay	Net 12ay
Brett P Monia	Chief Executive Officer	31 Ağustos 2026 J	242.760	0	13	$-30.324.088
HOUGEN ELIZABETH L	EVP, Finance & CFO	16 Mart 2026 M	82.660	0	5	$-17.867.127
Kleanthis G Xanthopoulos	President of Regulus	03 Aralık 2007 A	·	0	0	$0
Shannon L. Devers	EVP, Chief Human Resources Ofc	15 Ekim 2026 M	17.811	0	13	$-8.189.947
Eric Swayze	EVP Research	15 Ekim 2026 M	390	0	9	$-5.237.833
Brian Birchler	EVP, Corp and Development Ops	31 Ağustos 2026 J	102.883	0	4	$-1.832.349
O'NEIL PATRICK R.	EVP CLO & General Counsel	31 Ağustos 2026 J	59.205	0	4	$-2.222.334
BENNETT C FRANK	EVP, Chief Scientific Officer	31 Ağustos 2026 J	60.128	0	10	$-16.705.490
Holly B. Kordasiewicz	EVP, Chief Development Officer	07 Temmuz 2026 S	22.096	0	4	$-4.810.107
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	26 Haziran 2026 M	77.114	0	4	$-3.738.554
Joseph Baroldi	EVP, Chief Business Officer	26 Haziran 2026 M	4.669	0	11	$-2.568.009
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	15 Nisan 2026 M	23.713	0	4	$-3.334.240
Richard S Geary	EVP, Chief Development Officer	06 Kasım 2025 M	59.657	0	11	$-9.577.499
Onaiza Cadoret-Manier	EVP,Chf GL Pdt Str & Oper Ofc	02 Şubat 2024 S	35.788	0	0	$0
Stanley T Crooke	Exec Chairman of the Board	26 Ocak 2021 S	2.021	0	0	$0
Damien Mcdevitt	Chief Business Officer	15 Temmuz 2019 M	2.573	0	0	$0
Sarah Boyce	Chief Business Officer	15 Ocak 2018 M	8.931	0	0	$0
ECKER DAVID J	Vice President	02 Eylül 2008 M	0	0	0	$0
Michael J Treble	Vice President, Pres of Ibis	11 Ağustos 2008 M	0	0	0	$0
Jeffrey M Jonas	Executive Vice President	02 Ocak 2008 A	·	0	0	$0
Mark K Wedel	VP & Chief Medical Officer	06 Temmuz 2007 M	6.603	0	0	$0
LEVIN ARTHUR A	Vice President	25 Nisan 2007 M	1.674	0	0	$0
BROWN RICHARD K	Vice President	08 Mart 2006 M	2.348	0	0	$0
MCNEIL JOHN A	Vice President	03 Ocak 2005 A	·	0	0	$0
LOWENSTAM PATRICIA	Vice President	03 Ocak 2005 A	603	0	0	$0
STEIN ARON	Vice President	01 Temmuz 2004 J	1.536	0	0	$0
Hans A De Haan	VP, Drug Development	27 Nisan 2004 S	0	0	0	$0
LUNDSTEDT KAREN S	Vice President	10 Mart 2004 M	5.407	0	0	$0
COLE DOUGLAS L	Vice President	09 Mart 2004 M	9.616	0	0	$0
HOLMLUND JON T	Vice President	01 Temmuz 2003 J	983	0	0	$0
Michael R Hayden	Yönetim kurulu üyesi	31 Temmuz 2026 P	24.000	2	0	$1.058.700
Peter N Reikes	Yönetim kurulu üyesi	15 Temmuz 2026 A	14.222	0	0	$0
Ludwig Hantson	Yönetim kurulu üyesi	15 Temmuz 2026 A	·	0	0	$0
Joan E Herman	Yönetim kurulu üyesi	15 Temmuz 2026 M	51.306	0	2	$-3.173.720
BERTHELSEN SPENCER R	Yönetim kurulu üyesi	15 Temmuz 2026 M	161.233	0	2	$-1.193.280
Allene M. Diaz	Yönetim kurulu üyesi	07 Temmuz 2026 M	3.811	0	4	$-5.218.027
Michael J. Yang	Yönetim kurulu üyesi	01 Temmuz 2026 A	7.940	0	0	$0
Joseph Loscalzo	Yönetim kurulu üyesi	01 Temmuz 2026 A	36.330	0	5	$-7.085.472
Joseph Klein III	Yönetim kurulu üyesi	01 Temmuz 2026 A	11.014	0	12	$-5.996.036
Lynne B Parshall	Yönetim kurulu üyesi	15 Nisan 2026 S	51.344	0	3	$-794.967
Joseph H Wender	Yönetim kurulu üyesi	01 Aralık 2025 S	36.035	0	6	$-4.335.515
MUTO FREDERICK T	Yönetim kurulu üyesi	15 Temmuz 2022 M	59.597	0	0	$0
Breaux Castleman	Yönetim kurulu üyesi	01 Temmuz 2020 A	19.183	0	0	$0
REED JOHN C	Yönetim kurulu üyesi	06 Eylül 2012 M	0	0	0	$0
Richard D Dimarchi	Yönetim kurulu üyesi	01 Temmuz 2010 A	·	0	0	$0
GARIELI CHRISTOPHER	Yönetim kurulu üyesi	01 Temmuz 2005 A	155.431	0	0	$0
SKALETSKY MARK B	Yönetim kurulu üyesi	01 Temmuz 2004 A	·	0	0	$0

SEC Form 3/4/5 başvurularından yöneticiler; net = yalnızca açık piyasa Alış/Satış

ETF sahipliği 62 ETF'ler tarafından tutuluyor

20

Ağırlık yalnızca doğrudan öz sermaye varlıklarını (N-PORT) yansıtır; kaldıraçlı veya türev tabanlı fonlar gösterilmeyen ek swap pozisyonlarına sahip olabilir.

Fon	Ağırlık	Birimler	Tarih itibarıyla	Kaynak
ARKG · ARK ETF Trust	1,77%	531.633 NS	31 Temmuz 2026	N-PORT
BBP · ETFis Series Trust I	0,97%	18.522 NS	31 Temmuz 2026	N-PORT
FXH · First Trust Exchange-Traded AlphaDE…	0,89%	179.574 NS	31 Temmuz 2026	N-PORT
SSMG · Virtus ETF Trust II	0,87%	540 NS	31 Temmuz 2026	N-PORT
IBB · iShares Trust	0,67%	1.239.007 SH	11 Eylül 2026	Günlük
NUSC · Nushares ETF Trust	0,61%	151.535 NS	31 Temmuz 2026	N-PORT
LABU · Direxion Shares ETF Trust	0,48%	46.023 NS	31 Temmuz 2026	N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust …	0,48%	12.466 SH	23 Ekim 2026	Günlük
QQQJ · Invesco Exchange-Traded Fund Trust …	0,37%	98.330 SH	23 Ekim 2026	Günlük
VBK · VANGUARD INDEX FUNDS	0,34%	2.078.639 SH	19 Ağustos 2026	Günlük
FNY · First Trust Exchange-Traded AlphaDE…	0,31%	34.728 NS	31 Temmuz 2026	N-PORT
ISCG · iShares Trust	0,30%	52.262 SH	11 Eylül 2026	Günlük
IWP · iShares Trust	0,25%	873.674 SH	11 Eylül 2026	Günlük
BKMC · BNY Mellon ETF Trust	0,21%	26.705 NS	31 Temmuz 2026	N-PORT
MEDI · Harbor ETF Trust	0,20%	1.631 NS	31 Temmuz 2026	N-PORT
VFMO · VANGUARD WELLINGTON FUND	0,20%	50.927 SH	19 Ağustos 2026	Günlük
BBMC · J.P. Morgan Exchange-Traded Fund Tr…	0,18%	72.134 NS	31 Temmuz 2026	N-PORT
VHT · VANGUARD WORLD FUND	0,18%	471.609 SH	19 Ağustos 2026	Günlük
PRFZ · Invesco Exchange-Traded Fund Trust	0,17%	103.750 SH	23 Ekim 2026	Günlük
ESML · iShares Trust	0,16%	78.845 SH	11 Eylül 2026	Günlük
FSMD · FIDELITY COVINGTON TRUST	0,15%	74.249 NS	31 Temmuz 2026	N-PORT
VXF · VANGUARD INDEX FUNDS	0,15%	1.895.610 SH	19 Ağustos 2026	Günlük
VB · VANGUARD INDEX FUNDS	0,15%	3.600.281 SH	19 Ağustos 2026	Günlük
JMOM · J.P. Morgan Exchange-Traded Fund Tr…	0,15%	71.364 NS	31 Temmuz 2026	N-PORT
IYH · iShares Trust	0,15%	96.087 SH	11 Eylül 2026	Günlük
FFLG · FIDELITY COVINGTON TRUST	0,14%	16.403 NS	31 Temmuz 2026	N-PORT
PWS · Pacer Funds Trust	0,14%	629 NS	31 Temmuz 2026	N-PORT
SMMD · iShares Trust	0,13%	87.867 SH	11 Eylül 2026	Günlük
FHLC · FIDELITY COVINGTON TRUST	0,12%	74.568 NS	31 Temmuz 2026	N-PORT
WSGE · EA Series Trust	0,11%	1.255 NS	31 Temmuz 2026	N-PORT
FNX · First Trust Exchange-Traded AlphaDE…	0,10%	25.981 NS	31 Temmuz 2026	N-PORT
FAD · First Trust Exchange-Traded AlphaDE…	0,09%	10.429 NS	31 Temmuz 2026	N-PORT
WSML · iShares Trust	0,08%	9.648 SH	11 Eylül 2026	Günlük
EQAL · Invesco Exchange-Traded Fund Trust …	0,07%	13.535 SH	23 Ekim 2026	Günlük
IWR · iShares Trust	0,07%	673.792 SH	11 Eylül 2026	Günlük
LRND · New York Life Investments ETF Trust	0,05%	3.731 NS	31 Temmuz 2026	N-PORT
VONG · VANGUARD SCOTTSDALE FUNDS	0,04%	244.940 SH	19 Ağustos 2026	Günlük
MNZL · EA Series Trust	0,04%	194 NS	31 Temmuz 2026	N-PORT
DYNF · BlackRock ETF Trust	0,04%	269.218 SH	11 Eylül 2026	Günlük
IWF · iShares Trust	0,03%	582.970 SH	11 Eylül 2026	Günlük
VTI · VANGUARD INDEX FUNDS	0,02%	4.990.066 SH	19 Ağustos 2026	Günlük
VONE · VANGUARD SCOTTSDALE FUNDS	0,02%	27.263 SH	19 Ağustos 2026	Günlük
VTHR · VANGUARD SCOTTSDALE FUNDS	0,02%	13.860 SH	19 Ağustos 2026	Günlük
ESGV · VANGUARD WORLD FUND	0,02%	37.171 SH	19 Ağustos 2026	Günlük
TILT · FlexShares Trust	0,01%	6.110 NS	31 Temmuz 2026	N-PORT
IWB · iShares Trust	0,01%	113.547 SH	11 Eylül 2026	Günlük
IYY · iShares Trust	0,01%	6.926 SH	10 Eylül 2026	Günlük
ITOT · iShares Trust	0,01%	218.402 SH	11 Eylül 2026	Günlük
IWV · iShares Trust	0,01%	45.548 SH	10 Eylül 2026	Günlük
RECS · Columbia ETF Trust I	0,01%	14.074 NS	31 Temmuz 2026	N-PORT
VT · VANGUARD INTERNATIONAL EQUITY INDEX…	0,01%	144.631 SH	19 Ağustos 2026	Günlük
IWS · iShares Trust	0,01%	13.733 SH	10 Eylül 2026	Günlük
DCOR · Dimensional ETF Trust	0,00%	2.712 NS	31 Temmuz 2026	N-PORT
IWD · iShares Trust	0,00%	20.479 SH	11 Eylül 2026	Günlük
DFUS · Dimensional ETF Trust	0,00%	5.654 NS	31 Temmuz 2026	N-PORT
REVS · Columbia ETF Trust I	0,00%	82 NS	31 Temmuz 2026	N-PORT
DFAU · Dimensional ETF Trust	0,00%	1.669 NS	31 Temmuz 2026	N-PORT
DFSU · Dimensional ETF Trust	0,00%	236 NS	31 Temmuz 2026	N-PORT
VONV · VANGUARD SCOTTSDALE FUNDS	0,00%	5.617 SH	19 Ağustos 2026	Günlük
ISCB · iShares Trust	·	7.426 SH	11 Eylül 2026	Günlük
SMLF · iShares Trust	·	134.548 SH	11 Eylül 2026	Günlük
SMMV · iShares Trust	·	15.473 SH	01 Eylül 2026	Günlük

IONS Analist Uzlaşması Boğa ve ayı analist görüşleri, 12 aylık fiyat hedefi, yukarı yönlü potansiyel

21

derecelendirme · 31 analist AL

Medyan hedef $85.00 +98,0%

8 25,8% Güçlü Al

17 54,8% Al

6 19,4% Tut

0 0,0% Sat

0 0,0% Güçlü Sat

12 Aylık Fiyat Hedefi

23 analist · 2026-10-20

Ortalama hedef $83.83 +95,3%

← Tüm hedeflerin altında Mevcut fiyat $42.93

Düşük$54.00 Ortalama$83.83 Yüksek$105.00

Akran karşılaştırması (GICS alt sektörü) Anahtar metrikler sektördeki benzerlerine karşı

22

Mali yıl bazında, fiyatlar her şirketin son mali yıl kapanışına göredir.

Hisse Sembolü	Piyasa Değeri	P/E	Gelir YoY	Net Kar Marjı	ROE	Brüt Kar Marjı
IONS	$12.92B	-33.2	·	·	-68.1%	·
SYRE	$2.56B	10.1	-62.0%	·	-26.5%	·
ARWR	$4.68B	-3449.0	23258.2%	-0.20%	-0.50%	·
PRAX	$7.43B	-21.9	249.5%	·	-47.3%	·
IOVA	$1.12B	-2.5	60.6%	-148.4%	-56.0%	·
RYTM	$7.19B	-34.4	45.8%	-103.6%	-309.1%	·
GRAL	$3.45B	-7.7	17.2%	-277.5%	-16.7%	·

Metriklerim Kişisel izleme listeniz — Tam Temeller'den seçilen satırlar

26

Sizin için önemli olan metrikleri seçin — Yukarıdaki Tam Temeller bölümündeki herhangi bir satırın yanındaki + işaretine tıklayın.

Seçiminiz kaydedildi ve tüm hisse senetlerinde sizinle birlikte gelir.

IONS Ionis Pharmaceuticals, Inc. - Common Stock