ASND Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $227.87
P/E -56.7
EPS $-3.76
Revenue $720M
ROE 169.8%
52W Range $186–$282

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About Ascendis Pharma A/S - American Depositary Shares Company overview from Wikipedia

05 · wikidata
sectorHealthcare industryBiotechnology employees1,189 countryDK

10-Year Performance Revenue, net income, margins and EPS trends

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Revenue$720M
2017-12-31 → 2025-12-31
EPS$-3.76
2017-12-31 → 2025-12-31
Free Cash Flow·
2017-12-31 → 2023-12-31
Net margin-31.7%
2017-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend ASND 5Y avg Peer Median Verdict
P/E -56.75Y avg ≈-26.1 ≈-26.1 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

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Avg Surprise -319.6%
Next Report Nov 09, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 13, 2026 $0.72 $1.41 -48.9%
March 31, 2026 $-0.77 $0.21 -471.1%
Dec. 31, 2025 $-0.55 $-0.05 -1098.3%
Sept. 30, 2025 $-1.00 $-0.22 -345.6%
June 30, 2025 $-0.64 $-1.27 49.8%
March 31, 2025 $-1.58 $-1.52 -3.7%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

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Income Statement 16
Metric Trend 2025202420232022202120202019201820172016
Revenue $720M$364M$267M$51M$8M$7M$13M$11M$2M$5M
Cost of Revenue $95M$44M$44M$12M$4M$0$0···
Gross Profit $625M$319M$222M$39M$4M$7M$13M···
R&D Expense $304M$307M$413M$380M$296M$261M$192M$140M$100M$66M
SG&A Expense $458M$291M$264M$221M$160M$77M$48M$25M$13M$12M
Operating Income $-136M$-279M$-456M$-562M$-452M$-331M$-227M$-155M$-112M$-73M
Interest Expense $81M$66M$44M$31M$4M$2M$1M$127.0K$97.0K$5.0K
Interest Income $114M$26M$44M$52M$60M$2M$18M$25M$923.0K$7M
Pretax Income $-213M$-373M$-474M$-578M$-384M$-419M$-218M$-130M$-124M$-69M
Income Tax $15M$5M$7M$5M$-367.0K$-219.0K$-234.0K$-394.0K$-477.0K$-227.0K
Net Income $-228M$-378M$-481M$-583M$-384M$-419M$-218M$-130M$-124M$-69M
EPS (Basic) $-3.76$-6.53$-8.55$-10.40$-7.00···$-3.68$-2.58
EPS (Diluted) $-3.76$-6.53$-8.55$-10.40$-7.00···$-3.68$-2.58
Shares (Basic) 60,607,13157,891,57056,287,06056,071,79354,771,76350,616,52846,506,86241,085,23733,626,30526,564,414
Shares (Diluted) ········33,626,30526,564,414
EBITDA $-136M$-279M$-456M$-562M$-452M$-331M$-227M$-155M$-112M·
Balance Sheet 10
Metric Trend 2025202420232022202120202019201820172016
Cash & Equivalents $616M$560M$392M$445M$446M$585M$598M$278M$195M$180M
Inventory $302M$296M$209M$131M$75M$0····
Current Assets $1.11B$1.06B$703M$923M$806M$740M$611M$293M$205M$184M
PP&E (Net) $146M$99M$111M$129M$126M$108M$45M$4M$3M$2M
Goodwill ······$3M$3M$3M$3M
Total Assets $1.30B$1.18B$826M$1.09B$1.08B$980M$677M$319M$211M$190M
Accounts Payable ········$24M$13M
Current Liabilities $1.07B$908M$737M$171M$100M$53M$48M$39M$24M$13M
Total Liabilities $1.47B$1.29B$971M$826M$201M$141M$80M$39M$24M$13M
Stockholders' Equity $-163M$-106M$-146M$263M$884M$839M$597M$280M$187M$177M
Cash Flow 6
Metric Trend 2025202420232022202120202019201820172016
Operating Cash Flow $54M$-306M$-467M$-496M$-418M$-272M$-176M$-139M$-95M$-60M
CapEx ··$2M$14M$24M$20M$5M$3M$941.0K$672.0K
Investing Cash Flow $-8M$7M$286M$62M$-111M$-291M$-5M$-3M$-941.0K$-672.0K
Financing Cash Flow $36M$444M$134M$397M$351M$603M$494M$203M$125M$117M
Free Cash Flow ··$-470M$-510M$-441M$-291M$-181M$-141M$-96M·
Levered FCF ··$-515M$-541M$-445M$-293M$-181M$-142M$-96M·
Profitability 8
Metric Trend 2025202420232022202120202019201820172016
Gross Margin 86.8%87.8%83.4%76.3%54.7%·····
Operating Margin -18.9%-76.7%-170.8%-1097.9%-5808.6%-4755.1%-1695.1%-1462.6%-7290.3%·
Net Margin -31.7%-104.0%-180.5%-1139.6%-4931.6%-6025.5%-1630.0%-1229.5%-8097.8%·
Pretax Margin -29.5%-102.6%-177.8%-1129.1%-4936.3%-6028.7%-1631.8%-1233.3%-8129.0%·
EBITDA Margin -18.9%-76.7%-170.8%-1097.9%-5808.6%-4755.1%-1695.1%-1462.6%-7290.3%·
ROA -18.4%-37.7%-50.3%-53.6%-37.2%-50.6%-43.8%-49.1%-61.8%·
ROE 169.8%300.8%-818.4%-101.7%-44.5%-58.4%-49.7%-55.7%-68.1%·
ROIC 89.8%267.1%317.5%-215.3%-51.1%-39.4%-37.9%-55.1%-59.4%·
Liquidity & Solvency 3
Metric Trend 2025202420232022202120202019201820172016
Current Ratio 1.01.23.65.48.014.012.77.58.6·
Quick Ratio 0.60.62.02.64.411.112.57.18.2·
Interest Coverage -1.7-4.3-10.3-18.3-115.5-172.4-1095.3-1218.6-1149.9·
Efficiency 2
Metric Trend 2025202420232022202120202019201820172016
Asset Turnover 0.60.40.30.00.00.00.00.00.0·
Inventory Turnover 0.30.20.30.10.1·····
Per Share 3
Metric Trend 2025202420232022202120202019201820172016
Revenue / Share ········$0.05·
Cash Flow / Share ········$-2.83·
EPS (TTM) $-3.76$-6.53$-8.55$-10.40$-7.00···$-3.68·
Valuation (TTM) 4
Metric Trend 2025202420232022202120202019201820172016
Revenue TTM $720M$364M$267M$51M$8M$7M$13M$11M$2M·
Net Income TTM $-228M$-378M$-481M$-583M$-384M$-419M$-218M$-130M$-124M·
P/E -56.7-21.1-14.7-11.7-19.2···-10.9·
Earnings Yield -1.8%-4.7%-6.8%-8.5%-5.2%···-9.2%·

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

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Metric 2025-12-312024-12-312023-12-312023-01-012022-12-31
Revenue $720M $364M $267M · $51M
Gross Margin % 86.8% 87.8% 83.4% · 76.3%
Operating Margin % -18.9% -76.7% -170.8% · -1097.9%
Net Income $-228M $-378M $-481M · $-583M
Diluted EPS $-3.76 $-6.53 $-8.55 · $-10.40

Institutional owners (13F) 26 filers · $211.4M total · As of June 30, 2026

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Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 26
Value held $211.4M
New positions 2
Exited positions 254
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
2 254 3 1 ·

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair. Change vs prior quarter not shown: filer coverage differs too much between these two quarters for a reliable comparison.

Institution Value Shares % of tracked 13F Type
Frazier Life Sciences Management, L.P. $60,053,342 225,155 28.41% Shares
Camber Capital Management LP $43,150,000 250,000 20.41% Shares
NEUBERGER BERMAN GROUP LLC $38,062,278 142,705 18.01% Shares
ODDO BHF ASSET MANAGEMENT SAS $34,315,395 128,657 16.23% Shares
Quadrature Capital Ltd $10,894,178 40,845 5.15% Shares
TWO SIGMA ADVISERS, LP $10,107,576 47,400 4.78% Shares
Matisse Capital $5,964,592 26,077 2.82% Shares
Advisors Asset Management, Inc. $2,642,897 12,394 1.25% Shares
CIBC Private Wealth Group LLC $1,665,630 8,378 0.79% Shares
Skopos Labs, Inc. $931,389 4,072 0.44% Shares
Asset Management One Co., Ltd. $870,318 3,805 0.41% Shares
FERGUSON WELLMAN CAPITAL MANAGEMENT, INC $693,472 2,600 0.33% Shares
MidWestOne Financial Group, Inc. $654,007 3,067 0.31% Shares
DEARBORN PARTNERS LLC $346,736 1,300 0.16% Shares
Springhill Fund Asset Management (HK) Co Ltd $338,684 2,173 0.16% Shares
CWM, LLC $308,099 1,347 0.15% Shares
Shilanski & Associates, Inc. $259,248 1,304 0.12% Shares
Lindbrook Capital, LLC $44,264 284 0.02% Shares
FTB Advisors, Inc. $40,561 235 0.02% Shares
E Fund Management (Hong Kong) Co., Ltd. $22,404 84 0.01% Shares
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $10,293 45 0.00% Shares
Ninepoint Partners LP $6,935 26 0.00% Shares
Handelsbanken Fonder AB $3,538 15,467 0.00% Shares
IFP Advisors, Inc $3,423 14 0.00% Shares
Binnacle Investments Inc $596 3 0.00% Shares
HUNTINGTON NATIONAL BANK $244 1 0.00% Shares

Activists & 5%+ owners 5 positions

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Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
OrbiMed Advisors LLC, OrbiMed Capital GP V LLC, OrbiMed Global Healthcare GP LLC, OrbiMed Capital LLC ×16 filings May 22, 2020 · Initial filing · SEC
Vivo Ventures VII, LLC, Vivo Ventures Fund VII, L.P., Vivo Ventures VII Affiliates Fund, L.P., Vivo Opportunity, LLC, Vivo Opportunity Fund, L.P. ×3 filings Oct. 23, 2019 · Initial filing · SEC
Sofinnova Venture Partners IX, L.P. (“SVP IX”), Sofinnova Management IX, L.L.C. (“SM IX”), Dr. Michael F. Powell (“Powell”), Dr. James I. Healy (“Healy”), Dr. Anand Mehra (“Mehra”) ×5 filings Feb. 12, 2019 · Initial filing Passive investment SEC
Sofinnova Capital V FCPR (“SC V”), Sofinnova Partners SAS, a French corporation (“SP SAS”), Denis Lucquin (“Lucquin”), Antoine Papiernik (“Papiernik”), Monique Saulnier (“Saulnier”) ×3 filings Feb. 14, 2018 · Initial filing · SEC
Vivo Ventures VII, LLC FEIN, Vivo Ventures Fund VII, L.P. FEIN, Vivo Ventures VII Affiliates Fund, L.P. FEIN Feb. 17, 2015 · Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 5 insiders · 3 officers · 2 directors

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Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Scott Thomas Smith EVP & Chief Financial Officer June 2, 2026 P 4,367 2 0 $77,730
Mads Bodenhoff SVP & PAO Sept. 8, 2026 M 0 0 1 $-810,570
Flemming Steen Jensen EVP & Product Supply and Quality May 11, 2026 S 0 0 1 $-4,641,015
Lars Holtug Director Sept. 2, 2026 S 4,000 0 1 $-62,335
Jean Jacques Bienaime Director April 14, 2026 A 2,900 7 0 $699,338

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 20 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IBB · iShares Trust 1.20% 472,545 SH Sept. 11, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.92% 4,352 SH Oct. 1, 2026 Daily
QQQJ · Invesco Exchange-Traded Fund Trust … 0.71% 36,364 SH Oct. 1, 2026 Daily
IWP · iShares Trust 0.36% 264,896 SH Sept. 11, 2026 Daily
IDHQ · Invesco Exchange-Traded Fund Trust … 0.24% 11,454 SH Oct. 1, 2026 Daily
IYH · iShares Trust 0.21% 29,076 SH Sept. 11, 2026 Daily
SMMD · iShares Trust 0.18% 26,541 SH Sept. 11, 2026 Daily
IWR · iShares Trust 0.10% 204,724 SH Sept. 11, 2026 Daily
EQAL · Invesco Exchange-Traded Fund Trust … 0.08% 2,889 SH Oct. 1, 2026 Daily
PDN · Invesco Exchange-Traded Fund Trust … 0.06% 872 SH Oct. 1, 2026 Daily
VONG · VANGUARD SCOTTSDALE FUNDS 0.04% 74,541 SH Aug. 19, 2026 Daily
IWF · iShares Trust 0.04% 176,655 SH Sept. 11, 2026 Daily
VONE · VANGUARD SCOTTSDALE FUNDS 0.02% 8,179 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.02% 4,200 SH Aug. 19, 2026 Daily
IWB · iShares Trust 0.02% 34,351 SH Sept. 11, 2026 Daily
IWV · iShares Trust 0.02% 13,687 SH Sept. 11, 2026 Daily
OMFL · Invesco Exchange-Traded Self-Indexe… 0.01% 2,134 SH Oct. 1, 2026 Daily
IWS · iShares Trust 0.01% 4,100 SH Sept. 10, 2026 Daily
IWD · iShares Trust 0.00% 6,108 SH Sept. 11, 2026 Daily
VONV · VANGUARD SCOTTSDALE FUNDS 0.00% 1,675 SH Aug. 19, 2026 Daily

ASND Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

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rating · 28 analysts BUY
Median target $316.57 +38.9%
12 42.9% Strong Buy
15 53.6% Buy
1 3.6% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

20 analysts · 2026-09-30

Mean target $309.81 +36.0%

← Below all targets Current price $227.87
Low$265.74 Mean$309.81 High$354.56

Peer comparison (GICS sub-industry) Key metrics vs sector peers

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FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ASND · -56.7 · -31.7% 169.8% 86.8%
EVAX · · · -102.4% -16.2% ·

Latest News Recent headlines mentioning this company

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Source: SEC 20-F filed Feb 11, 2026