KPTI
NASDAQ
US
Karyopharm Therapeutics Inc. - Common Stock
$5.89
▲ +$0.07
(+1.20%)
Vol 185K
3
Quality Score
fail
Rev ✗
NI ✗
>IPO ✗
Mkt Cap
$125.5M
ROE
-182.4%
Margin
-87.4%
D/E
378.22
Beta
0.24
52W
$4–$12
Wall Street Consensus
13 analysts · Apr 20264
Strong Buy
7
Buy
2
Hold
0
Sell
0
Strong Sell
84.6%
Buy Rating
Price Chart
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Earnings
Beat rate: 25.0%| Quarter | EPS Est | EPS Act | Surprise |
|---|---|---|---|
| Dec 2025 | $-2.03 | $-2.22 | $-0.19 |
| Sep 2025 | $-3.19 | $-3.82 | $-0.63 |
| Jun 2025 | $-4.18 | $-4.32 | $-0.14 |
| Mar 2025 | $-4.26 | $-2.77 | +$1.49 |
Fundamentals Trend
| Metric | 2025-06-30 | 2025-09-02 | 2025-10-02 | 2025-11-03 | 2025-12-03 | 2026-01-02 |
|---|---|---|---|---|---|---|
| ROE (TTM) | — | -182.4% | -182.4% | -182.4% | -182.4% | -182.4% |
| P/E (TTM) | — | — | — | — | — | — |
| Net Margin | -98.2% | -90.0% | -90.0% | -90.0% | -87.4% | -87.4% |
| Gross Margin | 97.2% | 96.4% | 96.4% | 96.4% | 95.9% | 95.9% |
| D/E Ratio | — | 378.22 | 378.22 | 378.22 | 378.22 | 378.22 |
| Current Ratio | 0.99 | 0.99 | 0.99 | 0.99 | 1.03 | 1.03 |
Key Ratios
ROA (TTM)
-101.1%
P/S (TTM)
0.88
P/B
22.5
EPS (TTM)
$-14.58
CF/Share
$-1.29
Rev Growth 3Y
-11.5%
52W High
$12.45
52W Low
$3.51
$3.51
52-Week Range
$12.45
How does KPTI compare to Biotechnology peers?
Peer group: Micro-cap Biotechnology (All) · 528 companies
KPTI valuation vs Biotechnology peers
P/E ratio
—
▼
0%
below
peers
(18.8)
vs Peers
vs Industry
Undervalued
P/S ratio
0.9
▼
93%
below
peers
(12.9)
vs Peers
vs Industry
Undervalued
P/B ratio
22.5
▲
815%
above
peers
(2.5)
vs Peers
vs Industry
Overvalued
Div yield
—
▼
0%
below
peers
(0.0%)
vs Peers
vs Industry
Low yield
KPTI profitability vs Biotechnology peers
ROE
-182.4%
▼
171%
below
peers
(-67.3%)
vs Peers
vs Industry
Weak
Net margin
-87.4%
▲
70%
above
peers
(-286.8%)
vs Peers
vs Industry
Below avg
Gross margin
95.9%
▲
22%
above
peers
(78.6%)
vs Peers
vs Industry
Weak
ROA
-101.1%
▼
116%
below
peers
(-46.7%)
vs Peers
vs Industry
Weak
KPTI financial health vs Biotechnology peers
D/E ratio
378.2
▼
0%
below
peers
(0.0)
vs Peers
vs Industry
High debt
Current ratio
1.0
▼
77%
below
peers
(4.4)
vs Peers
vs Industry
Low liquidity
Beta
0.2
▼
75%
below
peers
(1.0)
vs Peers
vs Industry
More volatile
KPTI fundamentals radar
KPTI
Peer median
Industry
KPTI profitability vs leverage
Bubble size = market cap · X = net margin · Y = D/E ratio
KPTI vs peers: key metrics
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