SPRB Spruce Biosciences, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$52.88
Price · May 22, 2026
Fundamentals as of May 13, 2026

SPRB Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$52.88
Market Cap
$120M
P/E (TTM)
-1.7
EPS (TTM)
$-50.83
Revenue (TTM)
$0
Div Yield
ROE
-139.9%
Debt/Equity
0.0
52W Range
$7 – $838

SPRB Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $0
4-point trend, +0.00
2022-12-31 2025-12-31
EPS $-50.83
5-point trend, -2708.3%
2021-12-31 2025-12-31
Free Cash Flow
5-point trend, -102.8%
2020-12-31 2024-12-31
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
SPRB
Peer Median
P/E (TTM)
5-point trend, +100.0%
-1.7
579.2
P/B
5-point trend, -99.9%
2.8
2.2
EV / EBITDA
5-point trend, +100.0%
-1.9

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
SPRB
Peer Median
ROA
5-point trend, -171.4%
-79.3%
-74.7%
ROE
5-point trend, -282.3%
-139.9%
-99.1%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
SPRB
Peer Median
Debt / Equity
5-point trend, -100.0%
0.0
10.0
Current Ratio
5-point trend, -50.1%
5.2
2.6
Quick Ratio
5-point trend, -51.7%
4.8

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
SPRB
Peer Median
Revenue YoY
4-point trend, +0.00
-51.3%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
SPRB
Peer Median
EPS (Diluted)
5-point trend, -2708.3%
$-50.83

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
SPRB
Peer Median

SPRB Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 11 analysts
  • Strong Buy 4 36.4%
  • Buy 6 54.5%
  • Hold 1 9.1%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

5 analysts · 2026-05-25
Median target $150.00 +183.7%
Mean target $178.60 +237.7%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-3.6%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-8.94 $-8.99 0.05%
Dec. 31, 2025 $-11.28 $-8.15 -3.1%
Sept. 30, 2025 $-14.58 $-14.21 -0.37%
June 30, 2025 $-3.50 $-19.51 16.0%
March 31, 2025 $-24.00 $-16.42 -7.6%
Dec. 31, 2024 $-42.75 $-16.07 -26.7%

Peer Comparison Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
SPRB $120M -1.7 -51.3% -139.9%
OKUR -0.7 -1733.7% -88.6%
HRTX $245M -10.8 7.4% -13.0% 312.5% 73.3%
SPRO $131M 15.5 39.2% 12.8% 18.7%
HURA -1.2
EQ $95M -4.0 13.9% -133.1%
CNTB $159M -2.8 -99.8% -86687.5% -97.9%
BDTX $139M 6.2 31.9% 18.3%
VTVT -70.4%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 13
Annual Income Statement data for SPRB
Metric Trend 2025202420232022
Revenue 4-point trend, +0.00 $0 $5M $10M $0
R&D Expense 4-point trend, -44.5% $20M $46M $49M $35M
SG&A Expense 4-point trend, +40.6% $17M $15M $13M $12M
Operating Expenses 4-point trend, -22.8% $37M $61M $62M $47M
Operating Income 4-point trend, +22.8% $-37M $-56M $-52M $-47M
Interest Expense 4-point trend, -78.6% $90.0K $307.0K $483.0K $420.0K
Income Tax Flat — no change across 4 periods $0 $0 $0 $0
Net Income 4-point trend, +15.6% $-39M $-53M $-48M $-46M
EPS (Basic) 4-point trend, -2493.4% $-50.83 $-96.40 $-1.24 $-1.96
EPS (Diluted) 4-point trend, -2493.4% $-50.83 $-96.40 $-1.24 $-1.96
Shares (Basic) 4-point trend, -96.7% 766,598 550,146 38,510,220 23,527,116
Shares (Diluted) 4-point trend, -96.7% 766,598 550,146 38,510,220 23,527,116
EBITDA 4-point trend, +22.8% $-37M $-56M $-52M $-47M
Balance Sheet 22
Annual Balance Sheet data for SPRB
Metric Trend 2025202420232022
Cash & Equivalents 4-point trend, +99.7% $49M $39M $96M $24M
Short-term Investments 2-point trend, -100.0% · · $0 $55M
Receivables · · · $0
Prepaid Expense 4-point trend, -89.4% $353.0K $3M $4M $3M
Other Current Assets 4-point trend, +135.6% $3M $2M $2M $1M
Current Assets 4-point trend, -37.7% $52M $44M $102M $84M
Other Non-current Assets 4-point trend, -62.0% $243.0K $69.0K $582.0K $640.0K
Total Assets 4-point trend, -38.1% $53M $45M $104M $86M
Accounts Payable 4-point trend, -33.9% $943.0K $1M $3M $1M
Accrued Liabilities 3-point trend, -37.4% $9M $12M $15M ·
Current Liabilities 4-point trend, -19.0% $10M $15M $24M $12M
Capital Leases 4-point trend, -66.8% $419.0K $736.0K $1M $1M
Other Non-current Liabilities 4-point trend, -100.0% $0 $282.0K $236.0K $161.0K
Total Liabilities 4-point trend, -38.8% $11M $16M $27M $17M
Long-term Debt 4-point trend, -100.0% $0 $2M $4M $6M
Total Debt 4-point trend, -100.0% $0 $2M $3M $5M
Common Stock 4-point trend, -100.0% $0 $0 $4.0K $3.0K
Retained Earnings 4-point trend, -93.7% $-289M $-250M $-197M $-149M
AOCI 2-point trend, +100.0% · · $0 $-558.0K
Stockholders' Equity 4-point trend, -37.9% $43M $29M $77M $68M
Liabilities + Equity 4-point trend, -38.1% $53M $45M $104M $86M
Shares Outstanding 4-point trend, -94.2% 1,372,043 563,042 547,019 23,601,004
Cash Flow 9
Annual Cash Flow data for SPRB
Metric Trend 2025202420232022
D&A 4-point trend, -71.6% $21.0K $46.0K $70.0K $74.0K
Stock-based Comp 4-point trend, -29.1% $3M $5M $5M $4M
Operating Cash Flow 4-point trend, +20.0% $-33M $-56M $-33M $-42M
CapEx 3-point trend, -100.0% · $0 $7.0K $8.0K
Investing Cash Flow 3-point trend, -100.0% · $0 $56M $24M
Debt Issued · · · $0
Net Debt Issued 4-point trend, -2057000.00 $-2M $-2M $-2M $0
Financing Cash Flow 4-point trend, +18141.9% $43M $-2M $49M $-241.0K
Free Cash Flow 3-point trend, -34.2% · $-56M $-33M $-42M
Profitability 5
Annual Profitability data for SPRB
Metric Trend 2025202420232022
Operating Margin 2-point trend, -121.9% · -1143.4% -515.3% ·
Net Margin 2-point trend, -127.4% · -1079.9% -475.0% ·
EBITDA Margin 2-point trend, -121.9% · -1143.4% -515.3% ·
ROA 4-point trend, -82.2% -79.3% -71.1% -50.5% -43.5%
ROE 4-point trend, -122.6% -139.9% -131.8% -59.2% -62.8%
Liquidity & Solvency 5
Annual Liquidity & Solvency data for SPRB
Metric Trend 2025202420232022
Current Ratio 4-point trend, -23.1% 5.2 2.9 4.2 6.7
Quick Ratio 4-point trend, -23.7% 4.8 2.5 3.9 6.4
Debt / Equity 4-point trend, -100.0% 0.0 0.1 0.0 0.1
LT Debt / Equity 4-point trend, -100.0% 0.0 0.0 0.0 0.0
Interest Coverage 4-point trend, -260.4% -405.7 -182.9 -107.6 -112.6
Efficiency 1
Annual Efficiency data for SPRB
Metric Trend 2025202420232022
Asset Turnover 3-point trend, -100.0% 0.0 0.1 0.1 ·
Per Share 5
Annual Per Share data for SPRB
Metric Trend 2025202420232022
Book Value / Share 4-point trend, +967.9% $30.99 $0.68 $1.86 $2.90
Revenue / Share 3-point trend, -100.0% $0.00 $0.12 $0.26 ·
Cash Flow / Share 4-point trend, -2353.8% $-43.47 $-1.36 $-0.86 $-1.77
Cash / Share 4-point trend, +3335.6% $35.64 $0.92 $2.35 $1.04
EPS (TTM) 4-point trend, -2493.4% $-50.83 $-96.40 $-1.24 $-1.96
Growth Rates 1
Annual Growth Rates data for SPRB
Metric Trend 2025202420232022
Revenue YoY · -51.3% · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for SPRB
Metric Trend 2025202420232022
Revenue TTM 4-point trend, +0.00 $0 $5M $10M $0
Net Income TTM 4-point trend, +15.6% $-39M $-53M $-48M $-46M
Market Cap 4-point trend, -99.9% $120M $99.77B $676.22B $145.63B
Enterprise Value 4-point trend, -100.0% $71M $99.73B $676.13B $145.56B
P/E 4-point trend, +99.9% -1.7 -24.5 -13291.3 -3148.3
P/S 2-point trend, -69.7% · 20315.9 67025.8 ·
P/B 4-point trend, -99.9% 2.8 3461.8 8838.5 2126.5
P / Tangible Book 4-point trend, -99.9% 2.8 3461.8 8838.5 2126.5
P / Cash Flow 4-point trend, +99.9% -3.6 -1782.8 -20322.3 -3493.8
P / FCF 3-point trend, +49.0% · -1782.8 -20318.0 -3493.2
EV / EBITDA 4-point trend, +99.9% -1.9 -1776.2 -13004.2 -3078.5
EV / FCF 3-point trend, +49.0% · -1782.1 -20315.2 -3491.4
EV / Revenue 2-point trend, -69.7% · 20308.4 67016.5 ·
Earnings Yield 4-point trend, -194400.0% -58.4% -4.1% -0.01% -0.03%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $0$5M$10M$0
Operating Margin % -1143.4%-515.3%
Net Income $-39M$-53M$-48M$-46M$-42M
Diluted EPS $-50.83$-96.40$-1.24$-1.96$-1.81
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.00.10.00.10.0
Current Ratio 5.22.94.26.710.4
Quick Ratio 4.82.53.96.410.0
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-56M$-33M$-42M$-36M

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