Insider at

04

Insider transactions

05
0 buys (P) 40 sells (S) Net: $-11,374,650 + 45 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

45 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
Oct. 1, 2026 SYRE S 10b5-1 600 $89.14 $53,484 551,940 Direct -0.11% Disposed 4.5% (price as of 2026-10-02)
Oct. 1, 2026 SYRE S 10b5-1 2,683 $90.10 $241,738 549,257 Direct -0.49% Disposed 3.4% (price as of 2026-10-02)
Oct. 1, 2026 SYRE S 10b5-1 2,638 $91.49 $241,351 546,619 Direct -0.48% Disposed 1.9% (price as of 2026-10-02)
Oct. 1, 2026 SYRE S 10b5-1 3,989 $92.31 $368,225 542,630 Direct -0.73% Disposed 1.0% (price as of 2026-10-02)
Oct. 1, 2026 SYRE S 10b5-1 4,990 $93.37 $465,916 537,640 Direct -0.92% Disposed -0.2% (price as of 2026-10-02)
Oct. 1, 2026 SYRE S 10b5-1 100 $93.91 $9,391 537,540 Direct -0.02% Disposed -0.8% (price as of 2026-10-02)
Sept. 1, 2026 SYRE S 10b5-1 2,500 $86.36 $215,900 565,040 Direct -0.44% Disposed 7.9% (price as of 2026-10-02)
Sept. 1, 2026 SYRE S 10b5-1 8,400 $87.15 $732,060 556,640 Direct -1.49% Disposed 6.9% (price as of 2026-10-02)
Sept. 1, 2026 SYRE S 10b5-1 3,700 $88.06 $325,822 552,940 Direct -0.66% Disposed 5.8% (price as of 2026-10-02)
Sept. 1, 2026 SYRE S 10b5-1 400 $89.07 $35,628 552,540 Direct -0.07% Disposed 4.6% (price as of 2026-10-02)
Aug. 3, 2026 SYRE S 10b5-1 800 $93.97 $75,176 581,740 Direct -0.14% Disposed -0.8% (price as of 2026-10-02)
Aug. 3, 2026 SYRE S 10b5-1 7,157 $95.10 $680,631 574,583 Direct -1.23% Disposed -2.0% (price as of 2026-10-02)
Aug. 3, 2026 SYRE S 10b5-1 5,635 $95.93 $540,566 568,948 Direct -0.98% Disposed -2.9% (price as of 2026-10-02)
Aug. 3, 2026 SYRE S 10b5-1 1,392 $96.82 $134,773 567,556 Direct -0.24% Disposed -3.7% (price as of 2026-10-02)
Aug. 3, 2026 SYRE S 10b5-1 16 $97.46 $1,559 567,540 Direct 0.00% Disposed -4.4% (price as of 2026-10-02)
July 1, 2026 SYRE S 10b5-1 590 $88.91 $52,457 582,540 Direct -0.10% Disposed 4.8% (price as of 2026-10-02)
July 1, 2026 SYRE S 10b5-1 4,234 $88.12 $373,100 583,130 Direct -0.72% Disposed 5.8% (price as of 2026-10-02)
July 1, 2026 SYRE S 10b5-1 10,176 $87.44 $889,789 587,364 Direct -1.70% Disposed 6.6% (price as of 2026-10-02)
June 1, 2026 SYRE S 10b5-1 3,294 $71.38 $235,126 597,540 Direct -0.55% Disposed 30.6% (price as of 2026-10-02)
June 1, 2026 SYRE S 10b5-1 8,149 $70.50 $574,504 600,834 Direct -1.34% Disposed 32.2% (price as of 2026-10-02)
June 1, 2026 SYRE S 10b5-1 3,557 $69.40 $246,856 608,983 Direct -0.58% Disposed 34.3% (price as of 2026-10-02)
May 1, 2026 SYRE S 10b5-1 5,300 $69.54 $368,562 622,240 Direct -0.84% Disposed 34.0% (price as of 2026-10-02)
May 1, 2026 SYRE S 10b5-1 3,600 $70.77 $254,772 618,640 Direct -0.58% Disposed 31.7% (price as of 2026-10-02)
May 1, 2026 SYRE S 10b5-1 1,000 $71.76 $71,760 617,640 Direct -0.16% Disposed 29.9% (price as of 2026-10-02)
May 1, 2026 SYRE S 10b5-1 3,100 $73.14 $226,734 614,540 Direct -0.50% Disposed 27.4% (price as of 2026-10-02)
May 1, 2026 SYRE S 10b5-1 1,700 $74.23 $126,191 612,840 Direct -0.28% Disposed 25.5% (price as of 2026-10-02)
May 1, 2026 SYRE S 10b5-1 300 $74.96 $22,488 612,540 Direct -0.05% Disposed 24.3% (price as of 2026-10-02)
April 1, 2026 SYRE S 10b5-1 12,344 $49.20 $607,325 630,196 Direct -1.92% Disposed 89.4% (price as of 2026-10-02)
April 1, 2026 SYRE S 10b5-1 2,656 $49.92 $132,588 627,540 Direct -0.42% Disposed 86.7% (price as of 2026-10-02)
March 2, 2026 SYRE S 10b5-1 5,900 $41.73 $246,207 651,640 Direct -0.90% Disposed 123.3% (price as of 2026-10-02)
March 2, 2026 SYRE S 10b5-1 9,100 $42.49 $386,659 642,540 Direct -1.40% Disposed 119.3% (price as of 2026-10-02)
Feb. 2, 2026 SYRE S 10b5-1 957 $31.82 $30,452 671,583 Direct -0.14% Disposed 192.9% (price as of 2026-10-02)
Feb. 2, 2026 SYRE S 10b5-1 14,043 $32.87 $461,593 657,540 Direct -2.09% Disposed 183.5% (price as of 2026-10-02)
Jan. 2, 2026 SYRE S 10b5-1 12,709 $30.47 $387,243 674,198 Direct -1.85% Disposed 205.8% (price as of 2026-10-02)
Jan. 2, 2026 SYRE S 10b5-1 2,191 $31.79 $69,652 672,007 Direct -0.32% Disposed 193.1% (price as of 2026-10-02)
Jan. 2, 2026 SYRE S 10b5-1 100 $32.39 $3,239 671,907 Direct -0.01% Disposed 187.7% (price as of 2026-10-02)
Dec. 1, 2025 SYRE S 10b5-1 10,995 $28.73 $315,886 690,912 Direct -1.57% Disposed 224.4% (price as of 2026-10-02)
Dec. 1, 2025 SYRE S 10b5-1 4,005 $29.83 $119,469 686,907 Direct -0.58% Disposed 212.4% (price as of 2026-10-02)
Nov. 3, 2025 SYRE S 10b5-1 28,155 $23.13 $651,225 718,752 Direct -3.77% Disposed 302.9% (price as of 2026-10-02)
Nov. 3, 2025 SYRE S 10b5-1 16,845 $23.66 $398,553 701,907 Direct -2.34% Disposed 293.9% (price as of 2026-10-02)
Dec. 28, 2020 BBIO S 10b5-1 8,563 $69.94 $598,896 12,568 Direct -40.52% Disposed -3.8% (price as of 2026-10-02)
Dec. 28, 2020 BBIO S 10b5-1 10,937 $69.34 $758,372 21,131 Direct -34.11% Disposed -3.0% (price as of 2026-10-02)
Nov. 25, 2020 BBIO S 10b5-1 742 $47.23 $35,045 12,568 Direct -5.57% Disposed 42.4% (price as of 2026-10-02)
Nov. 24, 2020 BBIO S 10b5-1 4,258 $47.00 $200,126 12,568 Direct -25.31% Disposed 43.1% (price as of 2026-10-02)
Nov. 5, 2020 BBIO S 10b5-1 2,500 $42.05 $105,125 12,568 Direct -16.59% Disposed 59.9% (price as of 2026-10-02)
Sept. 30, 2020 BBIO S 10b5-1 2,058 $38.24 $78,698 12,568 Direct -14.07% Disposed 75.9% (price as of 2026-10-02)
Sept. 30, 2020 BBIO S 10b5-1 12,442 $37.59 $467,695 14,626 Direct -45.97% Disposed 78.9% (price as of 2026-10-02)
Sept. 18, 2020 BBIO S 10b5-1 2,500 $42.01 $105,025 12,568 Direct -16.59% Disposed 60.1% (price as of 2026-10-02)
Sept. 15, 2020 BBIO S 10b5-1 2,500 $37.06 $92,650 12,568 Direct -16.59% Disposed 81.5% (price as of 2026-10-02)
Sept. 11, 2020 BBIO S 10b5-1 2,000 $35.02 $70,040 12,568 Direct -13.73% Disposed 92.0% (price as of 2026-10-02)
June 30, 2020 BBIO S 300 $33.17 $9,951 9,823 Direct -2.96% Disposed 102.7% (price as of 2026-10-02)
June 30, 2020 BBIO S 9,700 $32.65 $316,705 10,123 Direct -48.93% Disposed 106.0% (price as of 2026-10-02)
April 27, 2020 BBIO S 10b5-1 2,000 $32.01 $64,020 9,823 Direct -16.92% Disposed 110.1% (price as of 2026-10-02)
April 8, 2020 BBIO S 10b5-1 8,000 $27.04 $216,320 9,823 Direct -44.89% Disposed 148.7% (price as of 2026-10-02)
Feb. 11, 2020 BBIO S 10b5-1 2,000 $37.28 $74,560 9,823 Direct -16.92% Disposed 80.4% (price as of 2026-10-02)

Showing latest 100 of 110 transactions

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
March 23, 2026 DMRA Stock Option (right to buy) Common Stock (37,313) $23.05 March 23, 2036 37,313 Acquired
Jan. 9, 2026 SYRE Stock Option (Right to Buy) Common Stock (528,000) $30.61 Jan. 9, 2036 528,000 Acquired
June 2, 2025 ORKA Stock Option (right to buy) Common Stock (17,500) $11.77 June 1, 2035 17,500 Acquired
Jan. 15, 2025 SYRE Stock Option (Right to Buy) Common Stock (370,000) $21.66 Jan. 15, 2035 370,000 Acquired
Feb. 1, 2024 SYRE Stock Option (Right to Buy) Common Stock (277,750) $25.86 Feb. 1, 2034 277,750 Acquired
Nov. 24, 2023 SYRE Series A Preferred Stock Common Stock (723,440) · · 18,086 Disposed
Nov. 22, 2023 SYRE Stock Option (Right to Buy) Common Stock (374,000) $10.39 Nov. 22, 2033 374,000 Acquired
Dec. 28, 2020 BBIO Stock Option (Right to Buy) Common Stock (6,000) $0.16 May 23, 2029 6,000 Disposed
Dec. 28, 2020 BBIO Stock Option (Right to Buy) Common Stock (6,000) $0.34 July 14, 2029 6,000 Disposed
Dec. 28, 2020 BBIO Stock Option (Right to Buy) Common Stock (7,500) $17.00 June 26, 2029 7,500 Disposed
Nov. 25, 2020 BBIO Stock Option (Right to Buy) Common Stock (742) $17.00 June 26, 2029 742 Disposed
Nov. 24, 2020 BBIO Stock Option (Right to Buy) Common Stock (4,258) $17.00 June 26, 2029 4,258 Disposed
Nov. 5, 2020 BBIO Stock Option (Right to Buy) Common Stock (2,500) $17.00 June 26, 2029 2,500 Disposed
Sept. 30, 2020 BBIO Stock Option (Right to Buy) Common Stock (6,000) $0.34 July 14, 2029 6,000 Disposed
Sept. 30, 2020 BBIO Stock Option (Right to Buy) Common Stock (6,000) $0.16 May 23, 2029 6,000 Disposed
Sept. 30, 2020 BBIO Stock Option (Right to Buy) Common Stock (2,500) $17.00 June 26, 2029 2,500 Disposed
Sept. 18, 2020 BBIO Stock Option (Right to Buy) Common Stock (2,500) $17.00 June 26, 2029 2,500 Disposed
Sept. 15, 2020 BBIO Stock Option (Right to Buy) Common Stock (2,500) $17.00 June 26, 2029 2,500 Disposed
Sept. 11, 2020 BBIO Stock Option (Right to Buy) Common Stock (2,000) $0.34 July 14, 2029 2,000 Disposed
June 30, 2020 BBIO Stock Option (Right to Buy) Common Stock (4,000) $0.34 July 14, 2029 4,000 Disposed
June 30, 2020 BBIO Stock Option (Right to Buy) Common Stock (6,000) $0.16 May 23, 2029 6,000 Disposed
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (49,766) $0.34 July 14, 2029 49,766 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (74,042) $0.16 May 23, 2029 74,042 Acquired
May 19, 2020 BBIO Stock Option (Right to Buy) Common Stock (1,082) $1.25 Aug. 23, 2027 1,082 Acquired
April 27, 2020 BBIO Stock Option (Right to Buy) Common Stock (2,000) $17.00 June 26, 2029 2,000 Disposed
April 8, 2020 BBIO Stock Option (Right to Buy) Common Stock (8,000) $17.00 June 26, 2029 8,000 Disposed
Feb. 11, 2020 BBIO Stock Option (Right to Buy) Common Stock (2,000) $17.00 June 26, 2029 2,000 Disposed
Jan. 8, 2020 BBIO Stock Option (Right to Buy) Common Stock (10,000) $17.00 June 26, 2029 10,000 Disposed
July 1, 2019 BBIO Management Incentive Units Common Stock (9,262) · · 9,262 Disposed
July 1, 2019 BBIO Management Incentive Units Common Stock (3,368) · · 3,368 Disposed

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 8 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Sept. 6, 2024 ORKA Common Stock 85,233 Indirect
Sept. 6, 2024 ORKA Warrant (Right to Buy)→ Common Stock (9,048) 9,048 Direct
June 30, 2023 SYRE Common Stock 576,699 Direct
June 30, 2023 SYRE Stock Option (Right to Buy)→ Common Stock (47,297,197) 47,297,197 Direct
June 30, 2023 SYRE Series A Preferred Stock→ Common Stock (18,086,000) 18,086,000 Direct
June 27, 2019 BBIO Management Incentive Units→ Common Stock · Direct
June 27, 2019 BBIO Management Incentive Units→ Common Stock · Direct
June 27, 2019 BBIO Stock Option (right to buy)→ Common Stock (300,000) 300,000 Direct

Compensation (DEF 14A)

08

Matched by name from proxy statements (DEF 14A) — verify against the filing.

Fiscal yearSalaryBonusStock awards Option awardsNon-equity incentivePension changeOtherTotal
2025 $665,000 · · · $475,475 · $14,000 $6,707,361
2024 $625,000 · · · $412,500 · $8,333 $6,960,186
2023 $272,850 $141,000 · · · · $5,203 $15,919,545
Fiscal yearSalaryBonusStock awards Option awardsNon-equity incentivePension changeOtherTotal
2020 $400,000 $210,000 · · · · $11,400 $4,561,482

Figures from the Summary Compensation Table of the company's proxy statement (DEF 14A). Compensation is not a recommendation.