ORKA Oruka Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$109.53
Price · Aug 19, 2026
Fundamentals as of Aug 10, 2026
52W Range
$14–$116
94% of range
Analyst Rating
BUY
20 analysts
Price Target
$154
+40% upside
P/E (TTM)
-11.8
ROE
-25.9%
Net Profit Margin
—

ORKA Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$109.53
Market Cap
$5.34B
P/E (TTM)
-11.8
EPS (TTM)
$-3.87
Revenue (TTM)
$0
Div Yield
—
ROE
-25.9%
Debt/Equity
—
52W Range
$14 – $116

ORKA Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $0
Flat — no change across 7 periods
2017-12-31 → 2023-12-31
EPS $-3.87
4-point trend, -178.4%
2021-12-31 → 2024-12-31
Free Cash Flow $-88M
9-point trend, -406.0%
2017-12-31 → 2025-12-31
Margins —

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ORKA
Peer Median
P/E (TTM)
5-point trend, +82.4%
-11.8
16.0
P/B
5-point trend, -57.0%
11.3
8.5
Price / FCF
5-point trend, +15.5%
-60.4
—

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ORKA
Peer Median
ROA
5-point trend, +35.0%
-23.8%
-45.0%
ROE
5-point trend, +28.0%
-25.9%
-86.5%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ORKA
Peer Median
Current Ratio
5-point trend, +43.8%
22.4
5.8
Quick Ratio
5-point trend, +43.7%
21.9
—

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ORKA
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ORKA
Peer Median
EPS (Diluted)
4-point trend, -178.4%
$-3.87
—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ORKA
Peer Median

Dividends Yield, payout ratio, dividend history, 5Y CAGR

Dividend Yield
—
Payout Ratio
—
5Y Div CAGR
—
Ex-dateAmount
Aug. 29, 2024$19.3560

ORKA Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 20 analysts
  • Strong Buy 9 45.0%
  • Buy 10 50.0%
  • Hold 1 5.0%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

12 analysts · 2026-08-17
Median target $155.50 +42.0%
Mean target $153.75 +40.4%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.07%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.55 $-0.53 -0.02%
March 31, 2026 $-0.48 $-0.56 0.08%
Dec. 31, 2025 $-0.45 $-0.64 0.19%
Sept. 30, 2025 $-0.55 $-0.59 0.04%
June 30, 2025 $-0.46 $-0.50 0.04%
March 31, 2025 $-0.40 $-0.52 0.12%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ORKA $1.48B -3.3 — — -25.9% —
IBRX $2.00B -5.2 668.3% -310.2% 71.0% —
RYTM $7.19B -34.4 45.8% -103.6% -309.1% —
TGTX $4.63B 10.8 87.3% 72.6% 96.7% —
CGON $3.35B -20.0 254.7% -3985.0% -22.6% —
SRRK $4.78B -13.4 — — -157.9% —
MIRM $4.10B -168.1 54.7% -4.5% -8.2% —

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for ORKA
Metric Trend 20252024202320222021202020192018201720162015
Revenue Flat — no change across 9 periods · · $0 $0 $0 $0 $0 $0 $0 $0 $0
R&D Expense 11-point trend, +1324.9% $101M $75M $1M $5M $14M $5M $2M $4M $14M $12M $7M
SG&A Expense 11-point trend, +387.5% $21M $13M $6M $6M $6M $5M $4M $4M $5M $4M $4M
Operating Expenses 11-point trend, +965.5% $122M $88M $7M $11M $19M $10M $6M $8M $19M $17M $11M
Operating Income 11-point trend, -965.5% $-122M $-88M $-7M $-11M $-19M $-10M $-6M $-8M $-19M $-17M $-11M
Interest Expense 5-point trend, +125.0% · · · · · $9.0K $7.0K $8.0K $6.0K · $4.0K
Interest Income 2-point trend, +183.6% $17M $6M · · · · · · · · ·
Other Non-op 2-point trend, -400.0% $-12.0K $4.0K · · · · · · · · ·
Pretax Income 8-point trend, -541.2% $-105M $-84M · · $-19M $-10M $-6M $-8M $-19M $-16M ·
Income Tax 9-point trend, +0.00 · · $0 $0 $0 $-9.0K $-167.0K $-31.0K $-61.0K $0 $0
Net Income 11-point trend, -821.2% $-105M $-84M $-5M $-10M $-19M $-10M $-5M $-8M $-18M $-16M $-11M
EPS (Basic) 4-point trend, -178.4% · $-3.87 $-0.37 $-0.69 $-1.39 · · · · · ·
EPS (Diluted) 4-point trend, -178.4% · $-3.87 $-0.37 $-0.69 $-1.39 · · · · · ·
Shares (Basic) 4-point trend, +20.8% · 16,789,362 14,415,877 14,410,143 13,903,871 · · · · · ·
Shares (Diluted) 4-point trend, +20.8% · 16,789,362 14,415,877 14,410,143 13,903,871 · · · · · ·
EBITDA 11-point trend, -965.5% $-122M $-88M $-7M $-11M $-19M $-10M $-6M $-8M $-19M $-17M $-11M
Balance Sheet 21
Annual Balance Sheet data for ORKA
Metric Trend 20252024202320222021202020192018201720162015
Cash & Equivalents 11-point trend, +21.0% $47M $62M $37M $42M $53M $49M $8M $7M $9M $7M $39M
Short-term Investments 2-point trend, -7.6% $290M $314M · · · · · · · · ·
Prepaid Expense 2-point trend, +458.0% $7M $1M · · · · · · · · ·
Other Current Assets 9-point trend, +41.2% · · $161.0K $254.0K $1M $897.0K $117.0K $169.0K $547.0K $282.0K $114.0K
Current Assets 11-point trend, +783.6% $344M $377M $38M $43M $54M $50M $8M $7M $12M $21M $39M
PP&E (Net) 11-point trend, +928.6% $288.0K $162.0K $10.0K $25.0K $48.0K $21.0K $10.0K $24.0K $42.0K $66.0K $28.0K
PP&E (Gross) 9-point trend, -46.5% · · $222.0K $229.0K $243.0K $271.0K $377.0K $398.0K $443.0K $453.0K $415.0K
Accum. Depreciation 9-point trend, -45.2% · · $212.0K $204.0K $195.0K $250.0K $367.0K $374.0K $401.0K $387.0K $387.0K
Other Non-current Assets 11-point trend, -83.7% $103.0K $43.0K $12.0K $18.0K $18.0K $12.0K $24.0K $24.0K $24.0K $766.0K $630.0K
Total Assets 11-point trend, +1134.7% $489M $396M $38M $43M $55M $50M $9M $7M $12M $25M $40M
Accounts Payable 9-point trend, -0.5% · · $362.0K $334.0K $1M $2M $418.0K $230.0K $622.0K $1M $364.0K
Current Liabilities 11-point trend, +922.2% $15M $13M $637.0K $1M $3M $3M $926.0K $793.0K $2M $2M $2M
Capital Leases 6-point trend, +221.0% $1M $755.0K $204.0K $280.0K $383.0K $409.0K · · · · ·
Total Liabilities 11-point trend, +1009.5% $17M $14M $841.0K $1M $4M $4M $926.0K $793.0K $2M $2M $2M
Common Stock 11-point trend, +444.4% $49.0K $37.0K $14.0K $14.0K $14.0K $10.0K $2.0K $1.0K $12.0K $9.0K $9.0K
Paid-in Capital 2-point trend, +42.0% $658M $463M · · · · · · · · ·
Retained Earnings 11-point trend, -96.9% $-189M $-84M $-189M $-183M $-173M $-154M $-144M $-139M $-131M $-113M $-96M
AOCI 4-point trend, +2973.7% $546.0K $-41.0K · · · · · · $-2.0K $-19.0K ·
Stockholders' Equity 11-point trend, +1139.6% $472M $382M $37M $42M $51M $47M $8M $6M $10M $22M $38M
Liabilities + Equity 11-point trend, +1134.7% $489M $396M $38M $43M $55M $50M $9M $7M $12M $25M $40M
Shares Outstanding 11-point trend, +438.3% 48,722,309 37,440,510 14,501,143 14,410,143 14,410,143 9,548,150 1,594,070 773,558 654,170 9,082,366 9,051,217
Cash Flow 11
Annual Cash Flow data for ORKA
Metric Trend 20252024202320222021202020192018201720162015
D&A 9-point trend, -21.1% · · $15.0K $20.0K $16.0K $8.0K $18.0K $22.0K $27.0K $24.0K $19.0K
Stock-based Comp 11-point trend, +3946.7% $24M $15M $686.0K $556.0K $497.0K $43.0K $151.0K $273.0K $458.0K $576.0K $599.0K
Operating Cash Flow 11-point trend, -737.4% $-88M $-58M $-5M $-11M $-19M $-8M $-5M $-8M $-17M $-15M $-11M
CapEx 11-point trend, +1800.0% $209.0K $189.0K $0 $2.0K $43.0K $19.0K $4.0K $4.0K $3.0K $12.0K $11.0K
Investing Cash Flow 9-point trend, -848.5% $-97M $-330M $0 $-2.0K $-43.0K $-19.0K $-4.0K $3M $13M · ·
Stock Issued 8-point trend, -98.2% $671.0K $54.0K · · $24M $51M $7M $4M $7M · $37M
Net Stock Activity 8-point trend, -98.2% $671.0K $54.0K · · $24M $51M $7M $4M $7M · $37M
Financing Cash Flow 9-point trend, +2812.9% $170M $450M $0 $0 $23M $48M $7M $3M $6M · ·
Net Change in Cash 7-point trend, -485.4% · · $-5M $-11M $4M $41M $2M $-2M $1M · ·
Free Cash Flow 11-point trend, -738.5% $-88M $-58M $-5M $-11M $-19M $-8M $-5M $-8M $-17M $-15M $-11M
Levered FCF 4-point trend, +55.6% · · · · · $-8M $-5M $-8M $-17M · ·
Profitability 3
Annual Profitability data for ORKA
Metric Trend 20252024202320222021202020192018201720162015
ROA 11-point trend, +42.0% -23.8% -42.3% -13.2% -20.3% -36.7% -33.0% -71.4% -82.7% -100.0% -51.2% -41.1%
ROE 11-point trend, +40.4% -25.9% -23.1% -14.2% -23.5% -35.9% -20.1% -66.8% -117.6% -150.2% -54.6% -43.3%
ROIC 4-point trend, +88.4% · · · · · -21.0% -74.1% -134.1% -181.5% · ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for ORKA
Metric Trend 20252024202320222021202020192018201720162015
Current Ratio 11-point trend, -13.6% 22.4 28.9 59.0 37.7 15.6 14.3 9.2 8.5 5.9 9.0 25.9
Quick Ratio 11-point trend, -15.0% 21.9 28.8 58.8 37.5 15.3 14.0 9.0 8.3 4.2 3.1 25.8
Interest Coverage 5-point trend, +62.1% · · · · · -1085.1 -830.6 -1014.8 -3118.7 · -2863.8
Efficiency 1
Annual Efficiency data for ORKA
Metric Trend 20252024202320222021202020192018201720162015
Asset Turnover Flat — no change across 9 periods · · 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Per Share 5
Annual Per Share data for ORKA
Metric Trend 20252024202320222021202020192018201720162015
Book Value / Share 11-point trend, +130.3% $9.69 $10.21 $2.55 $2.89 $3.54 $4.87 $4.77 $0.43 $0.87 $2.44 $4.21
Revenue / Share Flat — no change across 2 periods · · $0.00 $0.00 · · · · · · ·
Cash Flow / Share 3-point trend, -355.0% · $-3.44 $-0.35 $-0.76 · · · · · · ·
Cash / Share 11-point trend, -77.5% $0.96 $1.64 $2.58 $2.95 $3.70 $5.14 $5.25 $0.47 $0.74 $0.81 $4.29
EPS (TTM) 5-point trend, -567.6% $-9.28 $-3.87 $-0.37 $-0.69 $-1.39 · · · · · ·
Valuation (TTM) 9
Annual Valuation (TTM) data for ORKA
Metric Trend 20252024202320222021202020192018201720162015
Revenue TTM Flat — no change across 9 periods · · $0 $0 $0 $0 $0 $0 $0 $0 $0
Net Income TTM 11-point trend, -821.2% $-105M $-84M $-5M $-10M $-19M $-10M $-5M $-8M $-18M $-16M $-11M
Market Cap 11-point trend, -83.8% $1.48B $726M $296M $410M $372M $459M $109M $993M $3.43B $5.59B $9.09B
P/E 5-point trend, +82.4% -3.3 -5.0 -55.1 -41.2 -18.6 · · · · · ·
P/B 11-point trend, -98.7% 3.1 1.9 8.0 9.8 7.3 9.9 14.4 164.5 334.2 251.9 238.8
P / Tangible Book 6-point trend, -68.3% 3.1 1.9 8.0 9.8 7.3 9.9 · · · · ·
P / Cash Flow 11-point trend, +98.1% -16.7 -12.6 -59.0 -37.6 -19.8 -59.5 -22.8 -120.4 -196.5 -373.1 -863.0
P / FCF 11-point trend, +98.1% -16.7 -12.5 -59.0 -37.6 -19.8 -59.3 -22.7 -120.3 -196.5 -372.8 -862.1
Earnings Yield 5-point trend, -468.1% -30.6% -20.0% -1.8% -2.4% -5.4% · · · · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312024-02-062023-12-312022-12-31
Revenue ———$0$0
Net Income $-105M$-84M—$-5M$-10M
Diluted EPS —$-3.87—$-0.37$-0.69
Balance Sheet
2025-12-312024-12-312024-02-062023-12-312022-12-31
Current Ratio 22.428.9—59.037.7
Quick Ratio 21.928.8—58.837.5
Cash Flow
2025-12-312024-12-312024-02-062023-12-312022-12-31
Free Cash Flow $-88M$-58M—$-5M$-11M

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Institutional owners (13F) 265 filers · $5.6B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
108 (+50 vs prior Q) 25 (+7 vs prior Q) 84 (+28 vs prior Q) 50 (+14 vs prior Q) +20.0M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FMR LLC $674,010,785 7,082,177 11.93% Shares
Venrock Adviser, LLC $394,805,893 4,148,428 6.99% Shares
Fairmount Funds Management LLC $352,629,785 3,705,262 6.24% Shares
Capital World Investors $323,733,984 3,401,639 5.73% Shares
RTW INVESTMENTS, LP $298,741,485 3,139,030 5.29% Shares
STATE STREET CORP $254,384,117 2,673,090 4.50% Shares
VANGUARD CAPITAL MANAGEMENT LLC $224,693,610 2,360,971 3.98% Shares
Paradigm Biocapital Advisors LP $204,094,539 2,144,526 3.61% Shares
Deep Track Capital, LP $183,297,420 1,926,000 3.24% Shares
Bellevue Group AG $157,714,772 1,657,190 2.79% Shares
Remedium Capital Partners, LLC $149,003,957 1,565,661 2.64% Shares
RA CAPITAL MANAGEMENT, L.P. $147,950,996 1,554,597 2.62% Shares
VIKING GLOBAL INVESTORS LP $143,086,001 1,503,478 2.53% Shares
PERCEPTIVE ADVISORS LLC $128,009,646 1,345,063 2.27% Shares
GEODE CAPITAL MANAGEMENT, LLC $118,395,286 1,243,776 2.10% Shares
Polar Capital Holdings Plc $116,926,719 1,228,609 2.07% Shares
FRANKLIN RESOURCES INC $107,961,469 1,134,407 1.91% Shares
CITADEL ADVISORS LLC $106,496,277 1,119,011 1.89% Shares
BNP PARIBAS FINANCIAL MARKETS $102,689,858 1,079,015 1.82% Shares
Avidity Partners Management LP $72,369,552 760,424 1.28% Shares
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC $62,650,506 658,301 1.11% Shares
Aberdeen Group plc $61,569,565 646,943 1.09% Shares
WESTFIELD CAPITAL MANAGEMENT CO LP $60,093,479 631,433 1.06% Shares
Pictet Asset Management Holding SA $58,914,871 619,076 1.04% Shares
Affinity Asset Advisors, LLC $56,150,300 590,000 0.99% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $55,427,865 582,409 0.98% Shares
Cormorant Asset Management, LP $50,757,968 533,340 0.90% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $41,247,154 433,405 0.73% Shares
VANGUARD FIDUCIARY TRUST CO $34,797,007 365,630 0.62% Shares
Synergy Asset Management, LLC $33,909,166 356,301 0.60% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $33,785,636 355,003 0.60% Shares
SILVERARC CAPITAL MANAGEMENT, LLC $33,576,166 352,802 0.59% Shares
Candriam S.C.A. $33,535,685 352,716 0.59% Shares
BANK OF AMERICA CORP /DE/ $30,991,159 325,640 0.55% Shares
Holocene Advisors, LP $29,117,357 305,951 0.52% Shares
JENNISON ASSOCIATES LLC $28,480,289 299,257 0.50% Shares
Woodline Partners LP $27,146,957 285,247 0.48% Shares
BRAIDWELL LP $26,472,868 278,164 0.47% Shares
Siren, L.L.C. $23,792,500 250,000 0.42% Shares
EVENTIDE ASSET MANAGEMENT, LLC $22,840,800 240,000 0.40% Shares
Blackstone Inc. $22,565,568 237,108 0.40% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $20,846,000 219,039 0.37% Shares
SEB Asset Management AB $18,724,947 196,753 0.33% Shares
GREAT POINT PARTNERS LLC $17,447,516 183,330 0.31% Shares
Sio Capital Management, LLC $16,856,320 177,118 0.30% Shares
PFM Health Sciences, LP $15,115,375 158,825 0.27% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $15,074,928 158,400 0.27% Call option
First Turn Management, LLC $14,783,993 155,343 0.26% Shares
ExodusPoint Capital Management, LP $14,105,336 148,212 0.25% Shares
GOLDMAN SACHS GROUP INC $12,155,303 127,722 0.22% Shares
VICTORY CAPITAL MANAGEMENT INC $11,827,537 124,278 0.21% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $11,115,856 116,800 0.20% Put option
STEMPOINT CAPITAL LP $11,083,593 116,461 0.20% Shares
Parkman Healthcare Partners LLC $10,772,102 113,188 0.19% Shares
Apis Capital Advisors, LLC $10,659,040 112,000 0.19% Shares
DIMENSIONAL FUND ADVISORS LP $10,593,373 111,310 0.19% Shares
SEVEN GRAND MANAGERS, LLC $10,468,700 110,000 0.19% Shares
KENNEDY CAPITAL MANAGEMENT LLC $10,170,152 106,863 0.18% Shares
TD Asset Management Inc $9,797,180 102,944 0.17% Shares
Moody Aldrich Partners LLC $9,651,285 101,411 0.17% Shares
BlackRock, Inc. $9,637,390 101,265 0.17% Shares
TORONTO DOMINION BANK $8,549,787 89,837 0.15% Shares
Alyeska Investment Group, L.P. $8,350,596 87,744 0.15% Shares
Rhenman & Partners Asset Management AB $7,613,600 80,000 0.13% Shares
B Group, Inc. $7,137,750 75,000 0.13% Shares
VOYA INVESTMENT MANAGEMENT LLC $7,010,603 73,664 0.12% Shares
BARCLAYS PLC $6,884,504 72,339 0.12% Shares
AMERIPRISE FINANCIAL INC $6,884,027 72,334 0.12% Shares
PRUDENTIAL FINANCIAL INC $6,556,737 68,895 0.12% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $6,511,627 68,421 0.12% Shares
Fisher Asset Management, LLC $6,459,567 67,874 0.11% Shares
Ensign Peak Advisors, Inc $6,439,964 67,668 0.11% Shares
Secure Asset Management, LLC $6,271,585 65,899 0.11% Shares
CITIGROUP INC $6,109,343 64,194 0.11% Shares
Swiss National Bank $5,995,710 63,000 0.11% Shares
ALPS ADVISORS INC $5,806,702 61,014 0.10% Shares
RHUMBLINE ADVISERS $5,784,799 60,784 0.10% Shares
Informed Momentum Co LLC $5,616,362 59,014 0.10% Shares
Atika Capital Management LLC $5,547,745 58,293 0.10% Shares
Atle Fund Management AB $5,223,500 54,886 0.09% Shares
Granahan Investment Management, LLC $4,857,286 51,038 0.09% Shares
Burkehill Global Management, LP $4,758,500 50,000 0.08% Shares
Ghisallo Capital Management LLC $4,758,500 50,000 0.08% Shares
Trexquant Investment LP $4,721,955 49,616 0.08% Shares
Nuveen, LLC $4,471,087 46,980 0.08% Shares
Bank of New York Mellon Corp $4,302,350 45,207 0.08% Shares
Rafferty Asset Management, LLC $4,102,779 43,110 0.07% Shares
SECTORAL ASSET MANAGEMENT INC $3,995,903 41,987 0.07% Shares
HighVista Strategies LLC $3,987,813 41,902 0.07% Shares
WELLINGTON MANAGEMENT GROUP LLP $3,885,886 40,831 0.07% Shares
XTX Topco Ltd $3,854,956 40,506 0.07% Shares
PRINCIPAL FINANCIAL GROUP INC $3,418,983 35,925 0.06% Shares
Schonfeld Strategic Advisors LLC $3,317,625 34,860 0.06% Shares
ALLIANCEBERNSTEIN L.P. $3,241,224 66,080 0.06% Shares
Palo Alto Investors LP $3,192,573 33,546 0.06% Shares
Artia Global Partners LP $3,178,678 33,400 0.06% Shares
MILLENNIUM MANAGEMENT LLC $3,127,857 32,866 0.06% Shares
LAZARD ASSET MANAGEMENT LLC $3,063,617 32,191 0.05% Shares
FEDERATED HERMES, INC. $2,862,904 30,082 0.05% Shares
MetLife Investment Management, LLC $2,789,718 29,313 0.05% Shares

Company insiders 60 insiders · 14 officers · 29 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Lawrence Otto Klein Chief Executive Officer June 15, 2026 S 925,580 0 2 $-191,902
Jeffrey C. Dekker Chief Financial Officer Dec. 8, 2022 A 40,000 0 0 $0
Patrick M Wheeler Chief Financial Officer Sept. 18, 2014 S 101,510 0 0 $0
Kathryn E Falberg CFO and COO June 25, 2009 A 0 0 0 $0
Lee E Bendekgey Sr. VP CFO and General Counsel Feb. 1, 2008 A 6,511 0 0 $0
Henry Ward Wolff Sr. VP Finance and CFO Feb. 1, 2007 A 229 0 0 $0
Laura Lee Sandler Chief Operating Officer July 1, 2026 M 236,384 0 16 $-1,396,710
Thomas A Keuer Chief Operating Officer Dec. 8, 2022 A 40,730 0 0 $0
Michael R Bristow Pres. & Chief Executive Offic Dec. 14, 2021 A 41,155 0 0 $0
Brian L. Selby VP, Finance Dec. 21, 2020 A 0 0 0 $0
Michael D Levy Executive Vice President Feb. 1, 2008 A 20,821 0 0 $0
Gary Titus Chief Acct.Officer Aug. 30, 2006 S 2,633 0 0 $0
Peter S Garcia Senior V.P. and C.F.O. May 7, 2004 A — 0 0 $0
Linda A Fitzpatrick Senior V.P. of Human Resources May 7, 2004 A — 0 0 $0
Carl Dambkowski Director June 12, 2026 S 38,743 0 5 $-8,645,640
Christopher Nathan Martin Director June 2, 2026 A — 0 0 $0
Samarth Kulkarni Director June 2, 2026 A — 0 0 $0
Kristine M Ball Director June 2, 2026 A — 0 0 $0
Cameron Turtle Director June 2, 2025 A — 0 0 $0
Flynn James P. Director Jan. 30, 2024 A — 0 0 $0
Raymond L. Woosley Director Jan. 30, 2024 A — 0 0 $0
Linda S Grais Director Jan. 30, 2024 A — 0 0 $0
Anders D Hove Director Jan. 30, 2024 A — 0 0 $0
Robert E Conway Director Jan. 30, 2024 A 50,000 0 0 $0
Daniel J Mitchell Director Jan. 30, 2024 A 11,000 0 0 $0
Ma-Weaver Jacob Director June 15, 2022 A — 0 0 $0
ZABRISKIE JOHN L Director Sept. 17, 2013 A 156,131 0 0 $0
FORMELA JEAN FRANCOIS Director Oct. 22, 2012 A 1,579,542 0 0 $0
Burton E Sobel Director Feb. 10, 2012 A 0 0 0 $0
Richard B Brewer Director Feb. 10, 2012 A — 0 0 $0
William J Freytag Director Feb. 5, 2010 A — 0 0 $0
Mary K Pendergast Director Feb. 5, 2010 A 2,000 0 0 $0
Ted W Love Director Feb. 5, 2010 A 57,289 0 0 $0
David George Lowe Director July 21, 2009 S 129,600 0 0 $0
Kimberly J Popovits Director June 4, 2008 A — 0 0 $0
James R Gavin III Director June 4, 2008 A — 0 0 $0
Mark L Perry Director June 4, 2008 A 65,833 0 0 $0
Barry L Zubrow Director May 31, 2007 A 50,000 0 0 $0
George B Rathmann Director May 24, 2005 A 903,788 0 0 $0
Philippe Chambon Director May 6, 2004 A 5,759,875 0 0 $0
Carter Iii Thomas N Mc Director March 27, 2003 A — 0 0 $0
Funicular Funds, LP 10% owner July 1, 2022 J 2,580,452 0 0 $0
Jon Sakoda 10% owner Feb. 26, 2018 S 0 0 0 $0
Anthony A. Florence, Jr. 10% owner Feb. 26, 2018 S 0 0 0 $0
Peter W. Sonsini 10% owner Feb. 26, 2018 S 0 0 0 $0
Ravi Viswanathan 10% owner Feb. 26, 2018 S 0 0 0 $0
Forest Baskett 10% owner Feb. 26, 2018 S 0 0 0 $0
Scott D. Sandell 10% owner Feb. 26, 2018 S 0 0 0 $0
Joshua Makower 10% owner Feb. 26, 2018 S 0 0 0 $0
David M Mott 10% owner Feb. 26, 2018 S 0 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 9 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Fairmount Funds Management LLC, Fairmount Healthcare Fund II L.P., Fairmount Healthcare Co-Invest III L.P., Harwin Peter Evan, Kiselak Tomas ×7 filings July 1, 2026 19.50% Amendment — SEC
Adage Capital Management, L.P., Robert Atchinson, Phillip Gross ×2 filings Oct. 22, 2024 — Initial filing — SEC
Funicular Funds, LP, The Funicular Fund, LP, Jacob Ma-Weaver July 8, 2022 — Initial filing — SEC
The Funicular Fund, LP, Jacob Ma-Weaver ×6 filings June 21, 2022 — Initial filing — SEC
March 5, 2018 — Initial filing — SEC
Growth Equity Opportunities Fund IV, LLC, New Enterprise Associates 15, L.P., NEA Partners 15, L.P., NEA 15 GP, LLC, Peter J. Barris, Forest Baskett, Anthony A. Florence, Jr., Krishna S. Kolluri, Joshua Makower, David M. Mott, Jon M. Sakoda, Scott D. Sandell, Peter W. Sonsini, Ravi Viswanathan, Harry R. Weller June 29, 2015 — Initial filing Passive investment SEC
Atlas Venture Fund VII, L.P., Atlas Venture Associates VII, L.P. Nov. 2, 2012 — Initial filing — SEC
Credit Suisse, on behalf of the Investment Banking division March 15, 2006 — Initial filing — SEC
Undisclosed reporting person April 6, 2004 — Initial filing Board campaign SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 44 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
PTH · Invesco Exchange-Traded Fund Trust 2.70% 67,376 SH Aug. 8, 2026 Daily
SBIO · ALPS ETF Trust 1.81% 49,896 NS May 31, 2026 N-PORT
BBC · ETFis Series Trust I 1.68% 9,143 NS April 30, 2026 N-PORT
DWAS · Invesco Exchange-Traded Fund Trust … 1.18% 53,572 SH Aug. 8, 2026 Daily
LABU · Direxion Shares ETF Trust 0.57% 43,576 NS April 30, 2026 N-PORT
MEDI · Harbor ETF Trust 0.46% 1,846 NS April 30, 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0.41% 3,283 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.38% 372,279 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.31% 458,307 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.28% 53,886 SH Aug. 8, 2026 Daily
AFSM · First Trust Exchange-Traded Fund VI… 0.26% 4,318 NS May 31, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.21% 43,678 SH Aug. 8, 2026 Daily
AVSC · AMERICAN CENTURY ETF TRUST 0.17% 81,774 NS May 31, 2026 N-PORT
IWM · iShares Trust 0.16% 1,284,921 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.15% 289,905 SH Aug. 8, 2026 Daily
FMED · Fidelity Covington Trust 0.14% 1,000 NS May 31, 2026 N-PORT
BIB · ProShares Trust 0.14% 1,789 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.11% 14,532 NS May 31, 2026 N-PORT
CGMM · Capital Group Equity ETF Trust I 0.11% 52,068 NS May 31, 2026 N-PORT
SMMV · iShares Trust 0.08% 2,391 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.08% 16,691 NS April 30, 2026 N-PORT
ESML · iShares Trust 0.08% 23,190 SH Aug. 8, 2026 Daily
ITWO · ProShares Trust 0.07% 2,178 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.06% 234,870 NS May 31, 2026 N-PORT
ISCB · iShares Trust 0.05% 1,604 SH Aug. 8, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.05% 580,805 SH Aug. 8, 2026 Daily
UWM · ProShares Trust 0.04% 1,703 NS May 31, 2026 N-PORT
VHT · VANGUARD WORLD FUND 0.04% 94,538 SH Aug. 8, 2026 Daily
GSSC · Goldman Sachs ETF Trust 0.04% 6,385 NS May 31, 2026 N-PORT
URTY · ProShares Trust 0.03% 1,724 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.03% 1,930 SH Aug. 8, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.02% 9,959 NS April 30, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.02% 42,314 NS April 30, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.02% 5,464 SH Aug. 8, 2026 Daily
HDG · ProShares Trust 0.01% 43 NS May 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.01% 1,725,048 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.01% 4,138 SH Aug. 8, 2026 Daily
ONEQ · Fidelity Commonwealth Trust 0.01% 16,709 NS May 31, 2026 N-PORT
ITOT · iShares Trust 0.01% 68,265 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.01% 13,405 SH Aug. 8, 2026 Daily
SCHB · SCHWAB STRATEGIC TRUST 0.00% 28,726 NS May 31, 2026 N-PORT
AVUS · AMERICAN CENTURY ETF TRUST 0.00% 8,112 NS May 31, 2026 N-PORT
AVSU · AMERICAN CENTURY ETF TRUST 0.00% 64 NS May 31, 2026 N-PORT
DFUS · Dimensional ETF Trust 0.00% 1,553 NS April 30, 2026 N-PORT