Insider at

04

Insider transactions

05
0 buys (P) 0 sells (S) Net: $0 + 46 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

No open-market trades on record; showing all filings.

DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
June 17, 2026 GPCR A 39,453 · · 39,453 Direct · Acquired (price as of 2026-10-02)
May 15, 2026 PRTA A 27,000 · · 27,000 Direct · Acquired (price as of 2026-10-02)
May 14, 2026 RARE A 14,058 · · 14,058 Direct · Acquired (price as of 2026-10-02)
May 14, 2026 RARE A 7,751 · · 40,441 Direct +23.71% Acquired (price as of 2026-10-02)
June 23, 2025 GPCR A 51,804 · · 51,804 Direct · Acquired (price as of 2026-10-02)
May 15, 2025 RARE A 10,787 · · 10,787 Direct · Acquired (price as of 2026-10-02)
May 15, 2025 RARE A 5,740 · · 32,690 Direct +21.30% Acquired (price as of 2026-10-02)
May 14, 2025 PRTA A 20,183 · · 20,183 Direct · Acquired (price as of 2026-10-02)
June 25, 2024 GPCR A 37,500 · · 37,500 Direct · Acquired (price as of 2026-10-02)
June 18, 2024 RARE A 9,900 · · 9,900 Direct · Acquired (price as of 2026-10-02)
June 18, 2024 RARE A 5,345 · · 26,950 Direct +24.74% Acquired (price as of 2026-10-02)
May 24, 2024 NUVB M 293,203 $1.74 $510,173 293,203 Direct · Acquired 195.4% (price as of 2026-10-02)
May 24, 2024 NUVB M 366,744 $1.64 $601,460 659,947 Direct +125.08% Acquired 213.4% (price as of 2026-10-02)
May 24, 2024 NUVB M 293,203 · · 19,547 Direct -93.75% Disposed (price as of 2026-10-02)
May 24, 2024 NUVB M 366,744 · · 0 Direct -100.00% Disposed (price as of 2026-10-02)
May 15, 2024 PRTA A 15,000 · · 15,000 Direct · Acquired (price as of 2026-10-02)
Feb. 21, 2024 PRTA A 132,000 · · 132,000 Direct · Acquired (price as of 2026-10-02)
Aug. 3, 2023 GPCR J 205,500 $7.97 $1,637,835 205,500 Indirect · Acquired 247.2% (price as of 2026-10-02)
Aug. 3, 2023 GPCR J 205,500 $7.97 $1,637,835 205,500 Indirect · Acquired 247.2% (price as of 2026-10-02)
Aug. 3, 2023 GPCR J 411,000 $7.97 $3,275,670 768,122 Direct -34.86% Disposed 247.2% (price as of 2026-10-02)
June 7, 2023 RARE A 7,110 · · 7,110 Direct · Acquired (price as of 2026-10-02)
June 7, 2023 RARE A 3,860 · · 21,605 Direct +21.75% Acquired (price as of 2026-10-02)
May 15, 2023 NUVB A 366,744 · · 366,744 Direct · Acquired (price as of 2026-10-02)
Feb. 7, 2023 GPCR C 123,508 · · 0 Indirect -100.00% Disposed (price as of 2026-10-02)
Feb. 7, 2023 GPCR C 123,508 · · 123,508 Indirect · Acquired (price as of 2026-10-02)
June 24, 2022 RARE A 6,245 · · 6,245 Direct · Acquired (price as of 2026-10-02)
June 24, 2022 RARE A 3,300 · · 17,745 Direct +22.85% Acquired (price as of 2026-10-02)
May 16, 2022 NUVB A 140,713 · · 140,713 Direct · Acquired (price as of 2026-10-02)
May 16, 2022 NUVB A 118,784 · · 118,784 Direct · Acquired (price as of 2026-10-02)
Oct. 29, 2021 NUVB A 45,229 · · 45,229 Direct · Acquired (price as of 2026-10-02)
June 24, 2021 RARE A 4,125 · · 4,125 Direct · Acquired (price as of 2026-10-02)
June 24, 2021 RARE A 2,145 · · 14,445 Direct +17.44% Acquired (price as of 2026-10-02)
Feb. 10, 2021 NUVB A 312,750 · · 312,750 Direct · Acquired (price as of 2026-10-02)
Feb. 10, 2021 NUVB A 86,184 · · 86,184 Direct · Acquired (price as of 2026-10-02)
June 26, 2020 RARE A 4,250 · · 4,250 Direct · Acquired (price as of 2026-10-02)
June 26, 2020 RARE A 2,550 · · 12,300 Direct +26.15% Acquired (price as of 2026-10-02)
June 11, 2019 RARE A 5,000 · · 5,000 Direct · Acquired (price as of 2026-10-02)
June 11, 2019 RARE A 3,000 · · 9,750 Direct +44.44% Acquired (price as of 2026-10-02)
June 19, 2018 RARE A 5,000 · · 5,000 Direct · Acquired (price as of 2026-10-02)
June 19, 2018 RARE A 3,000 · · 6,750 Direct +80.00% Acquired (price as of 2026-10-02)
June 22, 2017 RARE A 3,750 · · 3,750 Direct · Acquired (price as of 2026-10-02)
June 22, 2017 RARE A 1,875 · · 3,750 Direct +100.00% Acquired (price as of 2026-10-02)
June 9, 2016 RARE A 1,875 · · 1,875 Direct · Acquired (price as of 2026-10-02)
June 9, 2016 RARE A 3,750 · · 3,750 Direct · Acquired (price as of 2026-10-02)
June 18, 2015 RARE A 7,500 · · 7,500 Direct · Acquired (price as of 2026-10-02)
April 8, 2015 RARE A 17,500 · · 17,500 Direct · Acquired (price as of 2026-10-02)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
June 17, 2026 GPCR Share Option (right to buy) Ordinary Shares · June 16, 2036 39,453 Acquired
May 15, 2026 PRTA Stock Option (Right to Buy) Ordinary Shares (27,000) $9.76 May 15, 2036 27,000 Acquired
May 14, 2026 RARE Stock Option (Right to Buy) Common Stock (14,058) $25.80 May 14, 2036 14,058 Acquired
June 23, 2025 GPCR Share Option (right to buy) Ordinary Shares · June 22, 2035 51,804 Acquired
May 15, 2025 RARE Stock Option (Right to Buy) Common Stock (10,787) $34.84 May 15, 2035 10,787 Acquired
May 14, 2025 PRTA Stock Option (Right to Buy) Ordinary Shares (20,183) $6.88 May 14, 2035 20,183 Acquired
June 25, 2024 GPCR Share Option (right to buy) Ordinary Shares · June 24, 2034 37,500 Acquired
June 18, 2024 RARE Stock Option (Right to Buy) Common Stock (9,900) $37.42 June 18, 2034 9,900 Acquired
May 24, 2024 NUVB Stock Option (Right to Buy) Class A Common Stock (293,203) $1.74 July 21, 2030 293,203 Disposed
May 24, 2024 NUVB Stock Option (Right to Buy) Class A Common Stock (366,744) $1.64 May 14, 2033 366,744 Disposed
May 15, 2024 PRTA Stock Option (Right to Buy) Ordinary Shares (15,000) $22.39 May 15, 2034 15,000 Acquired
Feb. 21, 2024 PRTA Stock Option (Right to Buy) Ordinary Shares (132,000) $27.05 Feb. 21, 2034 132,000 Acquired
Aug. 3, 2023 GPCR Stock option (right to buy) Ordinary Shares (205,500) $2.60 Jan. 19, 2032 205,500 Acquired
Aug. 3, 2023 GPCR Stock option (right to buy) Ordinary Shares (205,500) $2.60 Jan. 19, 2032 205,500 Acquired
Aug. 3, 2023 GPCR Stock option (right to buy) Ordinary Shares (411,000) $2.60 Jan. 19, 2032 411,000 Disposed
June 7, 2023 RARE Stock Option (Right to Buy) Common Stock (7,110) $51.82 June 7, 2033 7,110 Acquired
May 15, 2023 NUVB Stock Option (Right to Buy) Class A Common Stock (366,744) $1.64 May 14, 2033 366,744 Acquired
Feb. 7, 2023 GPCR Series B Preferred Shares Ordinary Shares (123,508) · · 123,508 Disposed
June 24, 2022 RARE Stock Option (Right to Buy) Common Stock (6,245) $60.57 June 24, 2032 6,245 Acquired
May 16, 2022 NUVB Stock Option (Right to Buy) Class A Common Stock (140,713) $4.05 May 15, 2032 140,713 Acquired
May 16, 2022 NUVB Stock Option (Right to Buy) Class A Common Stock (118,784) $4.05 May 15, 2032 118,784 Acquired
Oct. 29, 2021 NUVB Stock Option (Right to Buy) Class A Common Stock (45,229) $9.17 Oct. 28, 2031 45,229 Acquired
June 24, 2021 RARE Stock Option (Right to Buy) Common Stock (4,125) $93.20 June 24, 2031 4,125 Acquired
Feb. 10, 2021 NUVB Stock Option (Right to Buy) Class A Common Stock (312,750) $1.74 July 21, 2030 312,750 Acquired
Feb. 10, 2021 NUVB Stock Option (Right to Buy) Class A Common Stock (86,184) $4.60 Oct. 4, 2030 86,184 Acquired
June 26, 2020 RARE Stock Option (Right to Buy) Common Stock (4,250) $76.58 June 26, 2030 4,250 Acquired
June 11, 2019 RARE Stock Option (Right to Buy) Common Stock (5,000) $58.74 June 11, 2029 5,000 Acquired
June 19, 2018 RARE Stock Option (Right to Buy) Common Stock (5,000) $80.69 June 19, 2028 5,000 Acquired
June 22, 2017 RARE Employee Stock Option (Right to Buy) Common Stock (3,750) $65.66 June 22, 2027 3,750 Acquired
June 9, 2016 RARE Employee Stock Option (Right to Buy) Common Stock (3,750) $65.85 June 9, 2026 3,750 Acquired
June 18, 2015 RARE Stock Option (Right to Buy) Common Stock (7,500) $97.85 June 17, 2025 7,500 Acquired
April 8, 2015 RARE Stock Option (Right to Buy) Common Stock (17,500) $59.95 April 7, 2025 17,500 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 3 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Feb. 2, 2023 GPCR Series B Preferred Shares→ Ordinary Shares (123,508) 123,508 Indirect
Feb. 2, 2023 GPCR Stock option (right to buy)→ Ordinary Shares (1,179,122) 1,179,122 Direct
Feb. 12, 2021 NUVB No securities owned. 0 Direct