GPCR Structure Therapeutics Inc. - American Depositary Shares
$53.70
Price · Aug 19, 2026
Fundamentals as of Aug 6, 2026
52W Range
$18–$95
46% of range
Analyst Rating
BUY
23 analysts
Price Target
$105
+96% upside
P/E (TTM)
-67.1
ROE
-12.3%
Net Profit Margin
—
GPCR Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$53.70
Market Cap
$11.41B
P/E (TTM)
-67.1
EPS (TTM)
$-0.80
Revenue (TTM)
—
Div Yield
—
ROE
-12.3%
Debt/Equity
—
52W Range
$18 – $95
GPCR Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
—
EPS
$-0.80
2022-12-31
→
2025-12-31
Free Cash Flow
$-226M
2023-12-31
→
2025-12-31
Margins
—
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
GPCR
Peer Median
P/E (TTM)
-67.1
38.7
P/B
7.5
3.8
Price / FCF
-50.5
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
GPCR
Peer Median
ROA
-11.3%
-6.4%
ROE
-12.3%
-16.8%
ROIC
-11.7%
—
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
GPCR
Peer Median
Current Ratio
24.8
12.8
Quick Ratio
22.9
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
GPCR
Peer Median
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
GPCR
Peer Median
GPCR Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
23 analysts
- Strong Buy 8 34.8%
- Buy 13 56.5%
- Hold 2 8.7%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
15 analysts · 2026-08-14
Median
$104.00
← Below all targets
$53.70
Low
$69.50
High
$145.00
Median target
$104.00
+93.7%
Mean target
$105.10
+95.7%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
-0.49%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| June 30, 2026 | $-0.49 | $-0.41 | -0.08% |
| March 31, 2026 | $-0.35 | $-0.35 | 0.00% |
| Dec. 31, 2025 | $-1.22 | $-0.47 | -0.75% |
| Sept. 30, 2025 | $-1.11 | $-0.36 | -0.75% |
| June 30, 2025 | $-1.08 | $-0.28 | -0.80% |
| March 31, 2025 | $-0.81 | $-0.23 | -0.58% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| GPCR | $14.78B | -86.9 | — | — | -12.3% | — |
| EWTX | $2.64B | -15.2 | — | — | -30.2% | — |
| MANE | — | — | — | — | 82.6% | — |
| INDV | — | 21.9 | 4.3% | 17.0% | -118.3% | 80.2% |
| ELVN | $915M | -8.4 | — | — | -21.9% | — |
| AMLX | $1.33B | -7.9 | -77.1% | — | -61.2% | — |
| OGN | $1.87B | 10.0 | -2.9% | 3.0% | 25.2% | 53.3% |
| MBX | $1.42B | -13.3 | — | — | -29.6% | — |
| ALMS | — | -3.4 | — | -1011.8% | -61.9% | — |
| TARS | $3.48B | -51.5 | 146.7% | -14.7% | -19.7% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 12
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| R&D Expense | $225M | $109M | $70M | $36M | |
| SG&A Expense | $62M | $49M | $33M | $16M | |
| Operating Expenses | $177M | $158M | $103M | $53M | |
| Operating Income | $-177M | $-158M | $-103M | $-53M | |
| Pretax Income | $-141M | $-122M | $-89M | $-51M | |
| Income Tax | $515.0K | $310.0K | $236.0K | $17.0K | |
| Net Income | $-141M | $-123M | $-90M | $-51M | |
| EPS (Basic) | $-0.80 | $-0.78 | $-0.81 | $-5.51 | |
| EPS (Diluted) | $-0.80 | $-0.78 | $-0.81 | $-5.51 | |
| Shares (Basic) | 177,596,000 | 157,922,000 | 110,198,000 | 9,584,000 | |
| Shares (Diluted) | 177,596,000 | 157,922,000 | 110,198,000 | 9,584,000 | |
| EBITDA | $-177M | $-158M | $-103M | · |
Balance Sheet 21
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Cash & Equivalents | $800M | $170M | $130M | $26M | |
| Short-term Investments | $647M | $714M | $338M | $65M | |
| Prepaid Expense | $24M | $8M | $6M | $2M | |
| Current Assets | $1.57B | $891M | $474M | $93M | |
| PP&E (Net) | $7M | $3M | $3M | $1M | |
| PP&E (Gross) | $10M | $5M | $4M | $1M | |
| Accum. Depreciation | $3M | $2M | $644.0K | $349.0K | |
| Other Non-current Assets | $717.0K | $5M | $45.0K | $3M | |
| Total Assets | $1.58B | $903M | $482M | $98M | |
| Accounts Payable | $14M | $8M | $5M | $6M | |
| Current Liabilities | $63M | $36M | $25M | $13M | |
| Capital Leases | $4M | $2M | $4M | · | |
| Other Non-current Liabilities | $647.0K | $302.0K | $298.0K | · | |
| Total Liabilities | $68M | $38M | $29M | $13M | |
| Common Stock | $21.0K | $17.0K | $14.0K | $1.0K | |
| Paid-in Capital | $1.99B | $1.19B | $659M | $2M | |
| Retained Earnings | $-470M | $-329M | $-207M | $-117M | |
| AOCI | $1M | $914.0K | $521.0K | $-110.0K | |
| Stockholders' Equity | $1.52B | $865M | $453M | $-115M | |
| Liabilities + Equity | $1.58B | $903M | $482M | $98M | |
| Shares Outstanding | 212,513,000 | 171,860,000 | 139,220,000 | 10,527,000 |
Cash Flow 10
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Stock-based Comp | $29M | $19M | $8M | $3M | |
| Operating Cash Flow | $-222M | $-117M | $-79M | $-46M | |
| CapEx | $4M | $1M | $2M | $155.0K | |
| Investing Cash Flow | $90M | $-359M | $-268M | $-62M | |
| Stock Issued | · | $515M | · | · | |
| Net Stock Activity | · | $515M | · | · | |
| Financing Cash Flow | $763M | $515M | $452M | $29M | |
| Net Change in Cash | $630M | $40M | $104M | $-79M | |
| Taxes Paid | $634.0K | $370.0K | $12.0K | · | |
| Free Cash Flow | $-226M | $-118M | $-82M | · |
Profitability 3
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| ROA | -11.3% | -17.7% | -30.9% | · | |
| ROE | -12.3% | -13.9% | -27.8% | · | |
| ROIC | -11.7% | -18.3% | -22.8% | · |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Current Ratio | 24.8 | 24.7 | 19.1 | · | |
| Quick Ratio | 22.9 | 24.5 | 18.9 | · |
Valuation (TTM) 8
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Net Income TTM | $-141M | $-123M | $-90M | $-51M | |
| Market Cap | $14.78B | $4.66B | $5.67B | · | |
| P/E | -86.9 | -34.8 | -50.3 | · | |
| P/B | 9.7 | 5.4 | 12.5 | · | |
| P / Tangible Book | 9.7 | 5.4 | 12.5 | · | |
| P / Cash Flow | -66.5 | -40.0 | -71.4 | · | |
| P / FCF | -65.5 | -39.5 | -69.5 | · | |
| Earnings Yield | -1.1% | -2.9% | -2.0% | · |
Income Statement 12
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q2 2022 | Q1 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $100M | $67M | $69M | $59M | $55M | $43M | $33M | $33M | $22M | $21M | $18M | $19M | $13M | $8M | $10M | $8M | |
| SG&A Expense | $19M | $23M | $18M | $15M | $16M | $13M | $14M | $13M | $11M | $11M | $9M | $7M | $7M | $5M | $4M | $4M | |
| Operating Expenses | $119M | $89M | $-24M | $74M | $70M | $56M | $47M | $46M | $33M | $32M | $26M | $26M | $20M | $13M | $14M | $13M | |
| Operating Income | $-119M | $-89M | $24M | $-74M | $-70M | $-56M | $-47M | $-46M | $-33M | $-32M | $-26M | $-26M | $-20M | $-13M | $-14M | $-13M | |
| Pretax Income | $-106M | $-76M | $33M | $-66M | $-62M | $-47M | $-36M | $-34M | $-26M | $-26M | $-23M | $-23M | $-18M | $-12M | $-14M | $-13M | |
| Income Tax | $234.0K | $190.0K | $170.0K | $108.0K | $139.0K | $98.0K | $136.0K | $92.0K | $53.0K | $29.0K | $405.0K | $118.0K | $25.0K | $-180.0K | $64.0K | $60.0K | |
| Net Income | $-106M | $-76M | $33M | $-66M | $-62M | $-47M | $-36M | $-34M | $-26M | $-26M | $-24M | $-23M | $-18M | $-12M | $-14M | $-13M | |
| EPS (Basic) | $-0.49 | $-0.35 | $0.20 | $-0.37 | $-0.36 | $-0.27 | $-0.21 | $-0.20 | $-0.18 | $-0.19 | $-0.21 | $-0.20 | $-0.25 | $-1.16 | $-1.64 | $-1.44 | |
| EPS (Diluted) | $-0.49 | $-0.35 | $0.20 | $-0.37 | $-0.36 | $-0.27 | $-0.21 | $-0.20 | $-0.18 | $-0.19 | $-0.21 | $-0.20 | $-0.25 | $-1.16 | $-1.64 | $-1.44 | |
| Shares (Basic) | 217,957,000 | 217,326,000 | -342,571,000 | 175,469,000 | 172,647,000 | 172,051,000 | -301,657,000 | 171,630,000 | 148,239,000 | 139,710,000 | 114,948,000 | 114,759,000 | 71,655,000 | -18,694,000 | 9,435,000 | 9,063,000 | |
| Shares (Diluted) | 217,957,000 | 217,326,000 | 4,194,000 | 175,469,000 | 172,647,000 | 172,051,000 | -301,657,000 | 171,630,000 | 148,239,000 | 139,710,000 | 114,948,000 | 114,759,000 | 71,655,000 | -18,694,000 | 9,435,000 | 9,063,000 | |
| EBITDA | $-119M | $-89M | · | $-74M | $-70M | $-56M | · | $-46M | $-33M | $-32M | $-26M | $-26M | $-20M | · | · | · |
Balance Sheet 21
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q2 2022 | Q1 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $273M | $316M | $800M | $103M | $147M | $152M | $170M | $172M | $382M | $98M | $51M | $41M | $126M | $26M | · | · | |
| Short-term Investments | $1.07B | $1.14B | $647M | $696M | $639M | $685M | $714M | $743M | $545M | $339M | $155M | $184M | $114M | $65M | · | · | |
| Prepaid Expense | $29M | $32M | $24M | $15M | $13M | $13M | $8M | $8M | $11M | $13M | $5M | $4M | $5M | $2M | · | · | |
| Current Assets | $1.37B | $1.49B | $1.57B | $814M | $799M | $850M | $891M | $924M | $938M | $449M | $210M | $228M | $246M | $93M | · | · | |
| PP&E (Net) | $6M | $6M | $7M | $5M | $3M | $4M | $3M | $4M | $3M | $3M | $2M | $1M | $961.0K | $1M | · | · | |
| PP&E (Gross) | · | · | $10M | · | · | · | $5M | $5M | $4M | $4M | $3M | $2M | $1M | $1M | · | · | |
| Accum. Depreciation | · | · | $3M | · | · | · | $2M | $1M | $1M | $866.0K | $572.0K | $493.0K | $419.0K | $349.0K | · | · | |
| Other Non-current Assets | $41M | $6M | $717.0K | $7M | $6M | $6M | $5M | $2M | $2M | $47.0K | $350.0K | $38.0K | $59.0K | $3M | · | · | |
| Total Assets | $1.43B | $1.51B | $1.58B | $832M | $816M | $867M | $903M | $933M | $947M | $457M | $216M | $229M | $247M | $98M | · | · | |
| Accounts Payable | $11M | $8M | $14M | $18M | $9M | $9M | $8M | $8M | $2M | $7M | $3M | $6M | $5M | $6M | · | · | |
| Current Liabilities | $66M | $57M | $63M | $58M | $39M | $36M | $36M | $33M | $23M | $24M | $20M | $15M | $11M | $13M | · | · | |
| Capital Leases | $4M | $3M | $4M | $4M | $5M | $5M | $2M | $3M | $3M | $4M | $3M | · | · | · | · | · | |
| Other Non-current Liabilities | $1M | $863.0K | $647.0K | $325.0K | $317.0K | $308.0K | $302.0K | $309.0K | $293.0K | $296.0K | $281.0K | · | · | · | · | · | |
| Total Liabilities | $71M | $61M | $68M | $62M | $44M | $42M | $38M | $36M | $26M | $27M | $23M | $15M | $11M | $13M | · | · | |
| Common Stock | $21.0K | $21.0K | $21.0K | $18.0K | $17.0K | $17.0K | $17.0K | $17.0K | $17.0K | $14.0K | · | · | $11.0K | $1.0K | · | · | |
| Paid-in Capital | $2.01B | $2.00B | $1.99B | $1.27B | $1.21B | $1.20B | $1.19B | $1.19B | $1.18B | $663M | $375M | $373M | $371M | $2M | · | · | |
| Retained Earnings | $-652M | $-546M | $-470M | $-503M | $-438M | $-376M | $-329M | $-293M | $-259M | $-233M | $-182M | $-158M | $-135M | $-117M | · | · | |
| AOCI | $-3M | $-2M | $1M | $825.0K | $362.0K | $815.0K | $914.0K | $3M | $-487.0K | $-90.0K | $-310.0K | $-390.0K | $147.0K | $-110.0K | · | · | |
| Stockholders' Equity | $1.35B | $1.45B | $1.52B | $770M | $772M | $825M | $865M | $897M | $921M | $430M | $193M | $214M | $236M | $-115M | · | · | |
| Liabilities + Equity | $1.43B | $1.51B | $1.58B | $832M | $816M | $867M | $903M | $933M | $947M | $457M | $216M | $229M | $247M | $98M | · | · | |
| Shares Outstanding | 213,655,000 | 213,208,000 | 212,513,000 | 182,033,000 | 172,700,000 | 172,610,000 | 171,860,000 | 171,762,000 | 171,589,000 | 139,855,000 | · | · | 114,730,000 | 10,527,000 | · | · |
Cash Flow 8
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q2 2022 | Q1 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $13M | $12M | $8M | $7M | $8M | $6M | $6M | $6M | $4M | $3M | $2M | $2M | $3M | $623.0K | $643.0K | $620.0K | |
| Operating Cash Flow | $-120M | $15M | $-64M | $-51M | $-55M | $-52M | $-36M | $-20M | $-26M | $-34M | $-21M | $-17M | $-20M | $-12M | $-10M | $-14M | |
| CapEx | $-42.0K | $1M | $1M | $2M | $232.0K | $314.0K | $16.0K | $685.0K | $427.0K | $162.0K | $820.0K | · | · | $71.0K | $-53.0K | $65.0K | |
| Investing Cash Flow | $74M | $-497M | $56M | $-49M | $49M | $34M | $33M | $-189M | $-205M | $1M | $30M | $-69M | $-49M | $10M | $-16M | $-40M | |
| Stock Issued | · | · | · | · | · | · | · | $0 | · | · | · | · | · | · | · | · | |
| Financing Cash Flow | $2M | $-2M | $705M | $56M | $517.0K | $809.0K | $615.0K | $-757.0K | $515M | $702.0K | $473.0K | $-297.0K | $170M | $-316.0K | $31M | $-1M | |
| Net Change in Cash | $-44M | $-483M | $697M | $-44M | $-5M | $-17M | $-3M | $-209M | $284M | $-32M | $10M | $-86M | $100M | $-2M | $5M | $-55M | |
| Free Cash Flow | · | $14M | · | · | · | $-53M | · | · | · | $-34M | · | · | · | · | · | · |
Profitability 3
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q2 2022 | Q1 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -9.5% | -6.4% | · | -7.4% | -7.0% | -7.1% | · | -5.9% | -4.4% | -7.4% | -22.1% | · | -14.5% | · | · | · | |
| ROE | -10.0% | -6.7% | · | -7.9% | -7.3% | -7.5% | · | -6.2% | -4.6% | -7.8% | -24.7% | · | -15.2% | · | · | · | |
| ROIC | -8.8% | -6.2% | · | -9.6% | -9.2% | -6.8% | · | -5.1% | -3.6% | -7.5% | -13.8% | -12.2% | -8.3% | · | · | · |
Liquidity & Solvency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q2 2022 | Q1 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 20.8 | 26.2 | · | 14.2 | 20.5 | 23.3 | · | 27.6 | 41.4 | 19.1 | 10.5 | 15.2 | 22.4 | · | · | · | |
| Quick Ratio | 20.3 | 25.6 | · | 13.9 | 20.1 | 22.9 | · | 27.4 | 40.9 | 18.5 | 10.2 | 15.0 | 21.9 | · | · | · |
Valuation (TTM) 8
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q2 2022 | Q1 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-310M | $-250M | · | $-208M | $-169M | $-133M | · | $-110M | $-99M | $-91M | $-78M | $-68M | $-57M | · | · | · | |
| Market Cap | $11.47B | $10.28B | · | $5.10B | $3.58B | $2.99B | · | $7.54B | $6.74B | $5.99B | · | · | $2.73B | · | · | · | |
| P/E | -34.2 | · | · | · | -24.7 | -20.6 | · | -56.3 | -50.3 | -50.4 | -26.1 | -12.4 | -5.2 | · | · | · | |
| P/B | 8.5 | 7.1 | · | 6.6 | 4.6 | 3.6 | · | 8.4 | 7.3 | 13.9 | · | · | 11.5 | · | · | · | |
| P / Tangible Book | 8.5 | 7.1 | · | 6.6 | 4.6 | 3.6 | · | 8.4 | 7.3 | 13.9 | · | · | 11.5 | · | · | · | |
| P / Cash Flow | · | 674.6 | · | · | · | -57.2 | · | · | · | -175.9 | · | · | -134.4 | · | · | · | |
| P / FCF | · | 731.3 | · | · | · | -56.9 | · | · | · | -175.1 | · | · | · | · | · | · | |
| Earnings Yield | -2.9% | · | · | · | -4.0% | -4.9% | · | -1.8% | -2.0% | -2.0% | -3.8% | -8.1% | -19.3% | · | · | · |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Net Income | $-141M | $-123M | $-90M | $-51M |
| Diluted EPS | $-0.80 | $-0.78 | $-0.81 | $-5.51 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Current Ratio | 24.8 | 24.7 | 19.1 | — |
| Quick Ratio | 22.9 | 24.5 | 18.9 | — |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Free Cash Flow | $-226M | $-118M | $-82M | — |
Latest News Recent headlines mentioning this company
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Institutional owners (13F) 206 filers · $2.9B total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 32 (-8 vs prior Q) | 28 (-10 vs prior Q) | 71 (+3 vs prior Q) | 58 (-9 vs prior Q) | -489K |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Avoro Capital Advisors LLC | $351,836,637 | 6,555,555 | 12.00% | Shares |
| FMR LLC | $345,296,142 | 6,433,690 | 11.78% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $340,675,263 | 6,347,592 | 11.62% | Shares |
| Deep Track Capital, LP | $254,399,664 | 4,740,072 | 8.68% | Shares |
| BVF INC/IL | $180,697,390 | 3,366,823 | 6.16% | Shares |
| ORBIMED ADVISORS LLC | $118,578,498 | 2,209,400 | 4.05% | Shares |
| PRINCIPAL FINANCIAL GROUP INC | $94,070,254 | 1,752,753 | 3.21% | Shares |
| AMERICAN CENTURY COMPANIES INC | $90,282,956 | 1,682,179 | 3.08% | Shares |
| RTW INVESTMENTS, LP | $86,274,901 | 1,607,507 | 2.94% | Shares |
| Driehaus Capital Management LLC | $83,361,264 | 1,553,219 | 2.84% | Shares |
| BAKER BROS. ADVISORS LP | $76,883,831 | 1,432,529 | 2.62% | Shares |
| Casdin Capital, LLC | $63,062,250 | 1,175,000 | 2.15% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $58,285,620 | 1,086,000 | 1.99% | Shares |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | $55,875,837 | 1,041,100 | 1.91% | Shares |
| Siren, L.L.C. | $46,852,139 | 872,967 | 1.60% | Shares |
| Pacific Heights Asset Management LLC | $42,936,000 | 800,000 | 1.46% | Shares |
| Rock Springs Capital Management LP | $34,365,813 | 640,317 | 1.17% | Shares |
| Aberdeen Group plc | $34,344,238 | 639,915 | 1.17% | Shares |
| ALLIANCEBERNSTEIN L.P. | $29,484,326 | 611,708 | 1.01% | Shares |
| Logos Global Management LP | $26,835,000 | 500,000 | 0.92% | Shares |
| Parkman Healthcare Partners LLC | $26,065,426 | 485,661 | 0.89% | Shares |
| Davern Capital Partners, LP | $23,939,987 | 446,059 | 0.82% | Shares |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $22,476,996 | 418,800 | 0.77% | Shares |
| DEUTSCHE BANK AG\ | $17,811,302 | 331,867 | 0.61% | Shares |
| NEXTBio Capital Management LP | $16,771,660 | 312,496 | 0.57% | Shares |
| Catalio Capital Management, LP | $14,842,438 | 276,550 | 0.51% | Shares |
| MARSHALL WACE, LLP | $14,361,663 | 267,592 | 0.49% | Shares |
| HSG Holding Ltd | $13,672,433 | 254,750 | 0.47% | Shares |
| SEB Asset Management AB | $13,151,433 | 245,043 | 0.45% | Shares |
| BANK OF AMERICA CORP /DE/ | $12,579,336 | 234,383 | 0.43% | Shares |
| GOLDMAN SACHS GROUP INC | $12,520,889 | 233,294 | 0.43% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $11,581,986 | 215,800 | 0.40% | Shares |
| TWO SIGMA INVESTMENTS, LP | $10,957,053 | 204,156 | 0.37% | Shares |
| Eversept Partners, LP | $10,535,528 | 196,302 | 0.36% | Shares |
| Schonfeld Strategic Advisors LLC | $10,234,062 | 190,685 | 0.35% | Shares |
| Woodline Partners LP | $8,254,875 | 153,808 | 0.28% | Shares |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $8,218,000 | 153,119 | 0.28% | Shares |
| ArrowMark Colorado Holdings LLC | $8,081,575 | 150,579 | 0.28% | Shares |
| Susquehanna Portfolio Strategies, LLC | $7,994,039 | 148,948 | 0.27% | Shares |
| CenterBook Partners LP | $7,944,770 | 148,030 | 0.27% | Shares |
| Rhenman & Partners Asset Management AB | $7,787,517 | 145,100 | 0.27% | Shares |
| GOLDMAN SACHS GROUP INC | $7,782,150 | 145,000 | 0.27% | Call option |
| B Group, Inc. | $7,513,800 | 140,000 | 0.26% | Shares |
| HighVista Strategies LLC | $7,019,177 | 130,784 | 0.24% | Shares |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $6,745,728 | 125,689 | 0.23% | Shares |
| Squarepoint Ops LLC | $6,739,610 | 125,575 | 0.23% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6,566,202 | 122,344 | 0.22% | Shares |
| D. E. Shaw & Co., Inc. | $6,188,151 | 115,300 | 0.21% | Shares |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $6,027,141 | 112,300 | 0.21% | Shares |
| Soleus Capital Management, L.P. | $5,742,690 | 107,000 | 0.20% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5,302,596 | 98,800 | 0.18% | Call option |
| Avidity Partners Management LP | $5,259,660 | 98,000 | 0.18% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $5,215,811 | 97,183 | 0.18% | Shares |
| Qube Research & Technologies Ltd | $5,012,939 | 93,403 | 0.17% | Shares |
| PEREGRINE CAPITAL MANAGEMENT LLC | $4,949,930 | 92,229 | 0.17% | Shares |
| PFM Health Sciences, LP | $4,913,489 | 91,550 | 0.17% | Shares |
| PLATINUM INVESTMENT MANAGEMENT LTD | $4,849,782 | 90,363 | 0.17% | Shares |
| MILLENNIUM MANAGEMENT LLC | $4,807,115 | 89,568 | 0.16% | Shares |
| ExodusPoint Capital Management, LP | $4,200,536 | 78,266 | 0.14% | Shares |
| Boxer Capital Management, LLC | $4,025,250 | 75,000 | 0.14% | Shares |
| Cormorant Asset Management, LP | $4,025,250 | 75,000 | 0.14% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $4,025,250 | 75,000 | 0.14% | Shares |
| CITADEL ADVISORS LLC | $4,014,516 | 74,800 | 0.14% | Call option |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3,869,607 | 72,100 | 0.13% | Put option |
| ALPS ADVISORS INC | $3,855,277 | 71,833 | 0.13% | Shares |
| TD Asset Management Inc | $3,701,191 | 68,962 | 0.13% | Shares |
| Point72 Europe (London) LLP | $3,267,516 | 116,697 | 0.11% | Shares |
| Brevan Howard Capital Management LP | $3,258,144 | 60,336 | 0.11% | Shares |
| Burkehill Global Management, LP | $3,220,200 | 60,000 | 0.11% | Shares |
| JANE STREET GROUP, LLC | $3,026,988 | 56,400 | 0.10% | Call option |
| CITADEL ADVISORS LLC | $2,908,914 | 54,200 | 0.10% | Put option |
| TUDOR INVESTMENT CORP ET AL | $2,879,718 | 53,656 | 0.10% | Shares |
| ANTIPODES PARTNERS Ltd | $2,751,232 | 51,262 | 0.09% | Shares |
| SCOGGIN MANAGEMENT LP | $2,683,500 | 50,000 | 0.09% | Call option |
| Buckland Partners Management Co LLC | $2,683,500 | 50,000 | 0.09% | Shares |
| SEVEN GRAND MANAGERS, LLC | $2,683,500 | 50,000 | 0.09% | Shares |
| DAFNA Capital Management LLC | $2,495,655 | 46,500 | 0.09% | Shares |
| Mariner, LLC | $2,484,116 | 46,285 | 0.08% | Shares |
| STATE STREET CORP | $2,395,238 | 44,629 | 0.08% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $2,383,485 | 44,410 | 0.08% | Shares |
| BANQUE PICTET & CIE SA | $2,325,628 | 43,332 | 0.08% | Shares |
| Jump Financial, LLC | $2,289,455 | 42,658 | 0.08% | Shares |
| Cinctive Capital Management LP | $2,193,869 | 40,877 | 0.07% | Shares |
| Jefferies Financial Group Inc. | $2,180,344 | 40,625 | 0.07% | Shares |
| Jones Hill Capital LP | $2,177,231 | 40,567 | 0.07% | Shares |
| AMERIPRISE FINANCIAL INC | $2,117,656 | 39,457 | 0.07% | Shares |
| OSAIC HOLDINGS, INC. | $2,115,279 | 39,414 | 0.07% | Shares |
| STEMPOINT CAPITAL LP | $2,049,013 | 38,178 | 0.07% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2,045,256 | 38,108 | 0.07% | Shares |
| CAPITAL FUND MANAGEMENT S.A. | $2,000,871 | 37,281 | 0.07% | Shares |
| PSquared Asset Management AG | $1,996,524 | 37,200 | 0.07% | Shares |
| FLAX POND CAPITAL, LLC | $1,932,120 | 36,000 | 0.07% | Shares |
| TrueMark Investments, LLC | $1,803,312 | 33,600 | 0.06% | Shares |
| NOMURA ASSET MANAGEMENT CO LTD | $1,759,839 | 32,790 | 0.06% | Shares |
| DCF Advisers, LLC | $1,722,807 | 32,100 | 0.06% | Shares |
| EXCHANGE TRADED CONCEPTS, LLC | $1,651,587 | 30,773 | 0.06% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $1,534,962 | 28,600 | 0.05% | Shares |
| Verition Fund Management LLC | $1,530,615 | 28,519 | 0.05% | Shares |
| Y-Intercept (Hong Kong) Ltd | $1,479,843 | 27,573 | 0.05% | Shares |
| Seven Fleet Capital Management LP | $1,441,572 | 26,800 | 0.05% | Shares |
Company insiders 15 insiders · 4 officers · 8 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Raymond C Stevens | Chief Executive Officer | Feb. 7, 2023 P | — | 0 | 0 | $0 |
| Jun Yoon | Chief Financial Officer | Feb. 7, 2023 P | — | 0 | 0 | $0 |
| Mark Allen Bach | Chief Medical Officer | Feb. 7, 2023 P | — | 0 | 0 | $0 |
| Melita Sun Jung | Chief Business Officer | Feb. 7, 2023 P | — | 0 | 0 | $0 |
| Joanne Waldstreicher | Director | June 17, 2026 A | — | 0 | 0 | $0 |
| Angus C. Russell | Director | June 17, 2026 A | — | 0 | 0 | $0 |
| Sharon Tetlow | Director | June 17, 2026 A | — | 0 | 0 | $0 |
| Daniel G Welch | Director | June 17, 2026 A | 123,508 | 0 | 0 | $0 |
| Eric Dobmeier | Director | June 17, 2026 A | — | 0 | 0 | $0 |
| Ted W Love | Director | June 17, 2026 A | — | 0 | 0 | $0 |
| Ramy Farid | Director | Feb. 7, 2023 P | 3,260,495 | 0 | 0 | $0 |
| FMR LLC | 10% owner | July 22, 2026 S | 4,769,404 | 0 | 22 | $-7,057,088 |
| John Joseph Berrios | — | Aug. 6, 2026 A | 140,766 | 0 | 0 | $0 |
| Xichen Lin | — | Aug. 4, 2026 S | 228,960 | 0 | 5 | $-983,084 |
| FIL Ltd | — | Feb. 7, 2023 C | 624,239 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
ETF ownership Held by 14 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| SBIO · ALPS ETF Trust | 1.78% | 73,020 NS | May 31, 2026 | N-PORT |
| MID · AMERICAN CENTURY ETF TRUST | 0.70% | 17,825 NS | May 31, 2026 | N-PORT |
| FDG · AMERICAN CENTURY ETF TRUST | 0.57% | 59,428 NS | May 31, 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0.46% | 4,115 NS | April 30, 2026 | N-PORT |
| FMED · Fidelity Covington Trust | 0.44% | 4,628 NS | May 31, 2026 | N-PORT |
| HRTS · Tema ETF Trust | 0.35% | 4,583 NS | May 31, 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0.28% | 4,244 SH | Aug. 8, 2026 | Daily |
| IBB · iShares Trust | 0.24% | 430,126 SH | Aug. 8, 2026 | Daily |
| GDOC · Goldman Sachs ETF Trust | 0.20% | 1,008 NS | May 31, 2026 | N-PORT |
| MMSC · First Trust Exchange-Traded Fund VI… | 0.19% | 2,531 NS | May 31, 2026 | N-PORT |
| BIB · ProShares Trust | 0.15% | 2,880 NS | May 31, 2026 | N-PORT |
| FFSM · FIDELITY COVINGTON TRUST | 0.13% | 40,344 NS | April 30, 2026 | N-PORT |
| APIE · Trust for Professional Managers | 0.02% | 4,104 NS | May 31, 2026 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0.01% | 20,734 NS | May 31, 2026 | N-PORT |