Insider at

04

Insider transactions

05
0 buys (P) 1 sells (S) Net: $-2,520,000 + 44 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

44 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
March 26, 2026 PTGX S 24,000 $105.00 $2,520,000 60,845 Direct -28.29% Disposed 33.4% (price as of 2026-10-02)
March 12, 2020 PTGX P 12,000 $6.70 $80,400 15,310 Direct +362.54% Acquired 1990.4% (price as of 2026-10-02)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

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DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
March 26, 2026 PTGX Stock Option (right to buy) Common Stock (24,000) $12.88 Sept. 13, 2026 24,000 Disposed
Jan. 9, 2026 PTGX Stock Option (right to buy) Common Stock (14,299) $4.21 April 29, 2026 14,299 Disposed
Jan. 2, 2026 PTGX Stock Option (right to buy) Common Stock (3,762) $87.18 Jan. 2, 2036 3,762 Acquired
April 28, 2025 PTGX Stock Option (right to buy) Common Stock (10,725) $1.16 Oct. 28, 2025 10,725 Disposed
Jan. 2, 2025 PTGX Stock Option (right to buy) Common Stock (6,584) $38.98 Jan. 2, 2035 6,584 Acquired
March 7, 2024 PTGX Stock Option (right to buy) Common Stock (6,490) $1.89 Oct. 22, 2024 6,490 Disposed
Jan. 2, 2024 PTGX Stock Option (right to buy) Common Stock (25,700) $23.42 Jan. 2, 2034 25,700 Acquired
April 10, 2023 PTGX Stock Option (right to buy) Common Stock (6,196) $0.87 Sept. 26, 2023 6,196 Disposed
Jan. 16, 2023 PTGX Stock Option (right to buy) Common Stock (30,000) $12.17 Jan. 15, 2033 30,000 Acquired
May 26, 2022 PTGX Stock Option (right to buy) Common Stock (20,000) $8.31 May 26, 2032 20,000 Acquired
May 27, 2021 PTGX Stock Option (right to buy) Common Stock (18,000) $35.23 May 26, 2031 18,000 Acquired
May 28, 2020 PTGX Stock Option (right to buy) Common Stock (15,000) $16.54 May 27, 2030 15,000 Acquired
June 7, 2019 PTGX Stock Option (right to buy) Common Stock (12,000) $11.80 June 6, 2029 12,000 Acquired
April 1, 2019 PTGX Stock Option (right to buy) Common Stock (3,310) $1.31 May 14, 2019 3,310 Disposed
May 29, 2018 PTGX Stock Option (right to buy) Common Stock (12,000) $6.98 May 28, 2028 12,000 Acquired
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock (10,000) $4.40 July 11, 2020 10,000 Acquired
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock (10,000) $4.40 July 13, 2027 10,000 Disposed
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock (500) $28.20 July 11, 2020 500 Acquired
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock · June 9, 2026 500 Disposed
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock (450) $66.00 July 11, 2020 450 Acquired
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock · Oct. 22, 2025 450 Disposed
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock (550) $66.00 July 11, 2020 550 Acquired
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock · Oct. 22, 2025 550 Disposed
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock (197) $157.20 July 11, 2020 197 Acquired
Jan. 16, 2018 GYRE Stock Option (Right to Buy) Common Stock · May 13, 2020 197 Disposed
July 13, 2017 GYRE Stock Option (Right to Buy) Common Stock (10,000) $4.40 July 13, 2027 10,000 Acquired
May 25, 2017 PTGX Stock Option (right to buy) Common Stock (12,000) $8.59 May 25, 2027 12,000 Acquired
Sept. 13, 2016 PTGX Stock Option (right to buy) Common Stock (24,000) $12.88 Sept. 13, 2026 24,000 Acquired
June 9, 2016 GYRE Stock Option (Right to Buy) Common Stock (7,500) $1.88 June 9, 2026 7,500 Acquired
Oct. 22, 2015 GYRE Stock Option (Right to Buy) Common Stock (6,750) $4.40 Oct. 22, 2025 6,750 Acquired
Oct. 22, 2015 GYRE Stock Option (Right to Buy) Common Stock (6,750) $4.40 Oct. 22, 2025 6,750 Acquired
Oct. 22, 2015 GYRE Stock Option (Right to Buy) Common Stock (8,250) $4.40 Oct. 22, 2025 8,250 Acquired
Aug. 20, 2015 GYRE Warrant (Right to Buy) Common Stock (287) $33.27 April 9, 2019 287 Acquired
Aug. 20, 2015 GYRE Stock Option (Right to Buy) Common Stock (2,966) $10.48 May 13, 2020 2,966 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 5 holdings

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Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Aug. 10, 2016 PTGX Stock Option (right to buy)→ Common Stock (3,310) 3,310 Direct
Aug. 10, 2016 PTGX Stock Option (right to buy)→ Common Stock (6,196) 6,196 Direct
Aug. 10, 2016 PTGX Stock Option (right to buy)→ Common Stock (6,490) 6,490 Direct
Aug. 10, 2016 PTGX Stock Option (right to buy)→ Common Stock (10,724) 10,724 Direct
Aug. 10, 2016 PTGX Stock Option (right to buy)→ Common Stock (14,299) 14,299 Direct