your badges 52W Range $62–$161 79% of range Analyst Rating BUY 20 analysts Price Target $175 +25% upside P/E 136.0 ROE 11.0% Net Profit Margin 29.4%

PTGX Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $140.06
Market Cap (MRQ) $9.06B
P/E (TTM) 136.0
EPS (TTM) $1.03
Revenue (TTM) $282M
ROE (TTM) 11.0%
52W Range $62–$161

PTGX Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

04
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10-Year Performance Revenue, net income, margins and EPS trends

06
Revenue$46M
2017-12-31 → 2025-12-31
EPS$-2.05
2020-12-31 → 2025-12-31
Free Cash Flow$56M
2016-12-31 → 2025-12-31
Net margin29.4%
2018-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend PTGX 5Y avg Peer Median Verdict
P/E (TTM) 136.05Y avg ≈-13.4 ≈-13.4 · ·
P/S (TTM) 32.15Y avg ≈45.3 ≈45.3 28.1 Fair value
P/B (MRQ) 10.85Y avg ≈4.9 ≈4.9 8.1 Overvalued
Price / FCF (TTM) 69.45Y avg ≈14.3 ≈14.3 · ·
Price / Cash Flow (TTM) 69.05Y avg ≈13.7 ≈13.7 · ·
Price / Tangible Book 14.65Y avg ≈4.9 ≈4.9 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise 18.3%
Next Report Nov 04, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 4, 2026 $2.29 $2.12 7.8%
March 31, 2026 $0.05 $-0.54 109.2%
Dec. 31, 2025 $-0.69 $-0.50 -38.5%
Sept. 30, 2025 $-0.62 $-0.65 4.9%
June 30, 2025 $-0.55 $-0.59 6.8%
March 31, 2025 $-0.19 $-0.24 19.4%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

15
Income Statement 16
Metric Trend 202520242023202220212020201920182017
Revenue $46M$434M$60M$27M$27M$29M$231.0K$31M$20M
R&D Expense $159M$138M$120M$126M$126M$75M$65M$59M$46M
SG&A Expense $45M$43M$33M$32M$27M$19M$16M$14M$12M
Operating Expenses $204M$182M$154M$158M$153M$93M$81M$73M$58M
Operating Income $-158M$253M$-94M$-131M$-126M$-65M$-81M$-42M$-38M
Interest Expense ·····$598.0K$169.0K··
Interest Income $29M$26M$15M$4M$443.0K$900.0K$3M$3M$948.0K
Other Non-op $27.0K$250.0K$-201.0K$-80.0K$-149.0K$-46.0K$-1.0K$-20.0K$-8.0K
Pretax Income $-129M$279M$-79M$-127M$-126M$-65M$-78M$-40M$-37M
Income Tax $838.0K$4M$0$0$0$1M$-691.0K$-799.0K$0
Net Income $-130M$275M$-79M$-127M$-126M$-66M$-77M$-39M$-37M
EPS (Basic) $-2.05$4.47$-1.39$-2.60$-2.71$-1.92···
EPS (Diluted) $-2.05$4.23$-1.39$-2.60$-2.71$-1.92···
Shares (Basic) 63,573,04861,566,98956,763,55949,042,23246,322,91034,396,446···
Shares (Diluted) 63,573,04865,077,72256,763,55949,042,23246,322,91034,396,446···
EBITDA $-157M$254M$-93M$-130M$-125M$-64M$-80M$-42M$-37M
Balance Sheet 22
Metric Trend 202520242023202220212020201920182017
Cash & Equivalents $128M$97M$187M$126M$124M$117M$33M$82M$106M
Short-term Investments $439M$322M$155M$112M$203M$188M$100M$47M$38M
Prepaid Expense $10M$8M$4M$6M$9M$6M$6M$3M$4M
Other Current Assets $10.0K$248.0K$76.0K$42.0K····$1M
Current Assets $578M$592M$356M$243M$341M$316M$145M$138M$151M
PP&E (Net) $4M$3M$1M$2M$2M$1M$2M$861.0K$879.0K
PP&E (Gross) $12M$10M$7M$7M$6M$5M$4M$3M$2M
Accum. Depreciation $8M$7M$6M$5M$4M$3M$3M$2M$2M
Total Assets $668M$745M$358M$248M$348M$324M$155M$139M$164M
Accounts Payable $5M$2M$772.0K$4M$2M$3M$3M$6M$1M
Accrued Liabilities $28M$24M$19M$25M$38M$18M$12M$11M$10M
Current Liabilities $45M$47M$21M$31M$44M$40M$35M$26M$43M
Capital Leases $8M$10M·$1M$4M$4M$6M··
Other Non-current Liabilities ·····$121.0K···
Total Liabilities $53M$69M$21M$32M$48M$45M$75M$27M$43M
Long-term Debt ······$10M··
Common Stock $1.0K$1.0K$1.0K·····$0
Retained Earnings $-471M$-341M$-616M$-537M$-409M$-284M$-218M$-140M$-102M
AOCI $641.0K$-82.0K$-105.0K$-359.0K$-299.0K$28.0K$-221.0K$-233.0K$-6.0K
Stockholders' Equity $615M$675M$337M$216M$300M$280M$80M$113M$121M
Liabilities + Equity $668M$745M$358M$248M$348M$324M$155M$139M$164M
Shares Outstanding 62,577,89761,035,13957,708,61349,339,25247,838,33043,745,46527,217,64923,187,21921,088,306
Cash Flow 16
Metric Trend 202520242023202220212020201920182017
D&A $1M$826.0K$977.0K$1M$813.0K$948.0K$732.0K$527.0K$406.0K
Stock-based Comp $46M$38M$29M$24M$16M$8M$8M$7M$4M
Deferred Tax ·····$1M$-775.0K$-799.0K·
Other Non-cash $141M$-129M$-22M$-6M$478.0K$-16M$27M$-18M$36M
Operating Cash Flow $58M$184M$-70M$-108M$-108M$-72M$-42M$-50M$4M
CapEx $2M$1M$609.0K$795.0K$1M$471.0K$967.0K$486.0K$666.0K
Investing Cash Flow $-49M$-299M$-39M$91M$-16M$-91M$-54M$2M$16M
Debt Issued ······$10M··
Net Debt Issued ·····$-11M···
Stock Issued ··$108M·$124M$213M$34M$2M·
Net Stock Activity ··$108M·$124M$213M$34M$2M·
Financing Cash Flow $23M$26M$170M$19M$130M$248M$46M$24M$66M
Net Change in Cash $31M$-89M$61M$2M$6M$84M$-49M$-24M$85M
Taxes Paid $4M$2M·······
Free Cash Flow $56M$183M$-71M$-109M$-109M$-73M$-42M$-50M$3M
Levered FCF ·····$-74M$-43M··
Profitability 7
Metric Trend 202520242023202220212020201920182017
Operating Margin -343.6%58.2%-156.1%-494.2%-460.0%··-136.7%·
Net Margin -282.8%63.3%-131.6%-479.3%-458.9%··-125.9%·
Pretax Margin -281.0%64.3%-131.6%-479.3%-458.9%··-128.4%·
EBITDA Margin -340.9%58.4%-154.5%-490.4%-457.0%··-135.0%·
ROA -18.4%49.9%-26.1%-42.8%-37.4%-27.6%-52.4%-25.7%-28.7%
ROE -20.3%45.6%-24.7%-55.5%-39.9%-29.4%-88.0%-32.9%-35.5%
ROIC -25.9%36.9%-27.8%-60.9%-41.9%-23.5%-99.8%-38.3%-31.4%
Liquidity & Solvency 3
Metric Trend 202520242023202220212020201920182017
Current Ratio 12.712.516.77.87.77.84.15.33.5
Quick Ratio 12.58.816.17.67.47.63.84.93.4
Interest Coverage ·····-107.9-476.5··
Efficiency 1
Metric Trend 202520242023202220212020201920182017
Asset Turnover 0.10.80.20.10.1··0.2·
Per Share 5
Metric Trend 202520242023202220212020201920182017
Book Value / Share $9.82$11.06$5.83$4.37$6.27$6.39$2.94$4.85$5.72
Revenue / Share $0.72$6.68$1.06$0.54·····
Cash Flow / Share $0.91$2.83$-1.24$-2.21·····
Cash / Share $2.05$1.59$3.24$2.55$2.59$2.68$1.21$3.55$5.03
EPS (TTM) $-2.05$4.23$-1.39$-2.60$-2.71$-1.92···
Growth Rates 3
Metric Trend 202520242023202220212020201920182017
Revenue YoY -89.4%624.1%125.7%-2.8%-4.4%····
Revenue CAGR 3Y 20.1%151.3%28.0%······
Revenue CAGR 5Y 10.0%········
Valuation (TTM) 10
Metric Trend 202520242023202220212020201920182017
Revenue TTM $46M$434M$60M$27M$27M$29M$231.0K$31M$20M
Net Income TTM $-130M$275M$-79M$-127M$-126M$-66M$-77M$-39M$-37M
Market Cap $5.47B$2.36B$1.32B$538M$1.64B$882M$192M$156M$439M
P/E -42.69.1-16.5-4.2-12.6-10.5···
P/S 118.85.422.120.359.830.8830.75.021.9
P/B 8.93.53.92.55.53.22.41.43.6
P / Tangible Book 8.93.53.92.55.53.2···
P / Cash Flow 94.812.8-18.8-5.0-15.2-12.2-4.6-3.1113.3
P / FCF 97.512.9-18.7-4.9-15.0-12.1-4.5-3.1136.8
Earnings Yield -2.4%11.0%-6.1%-23.8%-7.9%-9.5%···

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

16
Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $46M $434M $60M $27M $27M
Operating Margin % -343.6% 58.2% -156.1% -494.2% -460.0%
Net Income $-130M $275M $-79M $-127M $-126M
Diluted EPS $-2.05 $4.23 $-1.39 $-2.60 $-2.71

Institutional owners (13F) 367 filers · $9.5B total · As of Sept. 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 367
Value held $9.5B
New positions 64
Exited positions 34
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
64 (+2 vs prior Q) 34 (-14 vs prior Q) 143 (+30 vs prior Q) 90 (-17 vs prior Q) +3.7M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
BlackRock, Inc. $1,263,534,678 10,307,837 13.28% Shares
FARALLON CAPITAL MANAGEMENT, L.L.C. $778,248,897 6,348,906 8.18% Shares
RTW INVESTMENTS, LP $620,398,832 5,061,175 6.52% Shares
VANGUARD GROUP INC $472,831,684 5,413,690 4.97% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $444,879,349 3,629,298 4.68% Shares
WELLINGTON MANAGEMENT GROUP LLP $418,829,015 3,416,781 4.40% Shares
UBS Group AG $416,676,511 3,399,221 4.38% Shares
STATE STREET CORP $407,156,089 3,321,554 4.28% Shares
VANGUARD CAPITAL MANAGEMENT LLC $349,769,037 2,853,394 3.68% Shares
JANUS HENDERSON GROUP PLC $304,866,424 2,891,527 3.20% Shares
JOHNSON & JOHNSON $300,220,852 2,449,183 3.16% Shares
Invesco Ltd. $286,918,961 2,340,667 3.02% Shares
GEODE CAPITAL MANAGEMENT, LLC $213,475,772 1,741,209 2.24% Shares
Woodline Partners LP $173,349,326 1,414,173 1.82% Shares
BANK OF AMERICA CORP /DE/ $162,356,964 1,324,498 1.71% Shares
JENNISON ASSOCIATES LLC $141,173,058 1,151,681 1.48% Shares
PERCEPTIVE ADVISORS LLC $120,358,728 981,879 1.27% Shares
ADAR1 Capital Management, LLC $117,782,587 960,863 1.24% Shares
MORGAN STANLEY $111,056,578 905,992 1.17% Shares
Alyeska Investment Group, L.P. $109,010,149 889,298 1.15% Shares
Hood River Capital Management LLC $108,206,024 882,738 1.14% Shares
GOLDMAN SACHS GROUP INC $99,639,398 812,852 1.05% Shares
Driehaus Capital Management LLC $89,612,477 731,053 0.94% Shares
Clearbridge Investments, LLC $88,911,554 725,335 0.93% Shares
FMR LLC $82,396,533 672,186 0.87% Shares
NORTHERN TRUST CORP $81,651,153 666,105 0.86% Shares
AMERICAN CENTURY COMPANIES INC $73,376,587 598,600 0.77% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $71,559,017 583,774 0.75% Shares
VOYA INVESTMENT MANAGEMENT LLC $70,068,935 571,618 0.74% Shares
Pictet Asset Management Holding SA $69,624,214 567,990 0.73% Shares
FRANKLIN RESOURCES INC $63,745,523 520,032 0.67% Shares
VANGUARD FIDUCIARY TRUST CO $53,659,027 437,747 0.56% Shares
PRINCIPAL FINANCIAL GROUP INC $47,225,415 385,262 0.50% Shares
Bank of New York Mellon Corp $43,920,414 358,300 0.46% Shares
NEUBERGER BERMAN GROUP LLC $37,071,502 302,427 0.39% Shares
BNP PARIBAS FINANCIAL MARKETS $36,954,438 301,472 0.39% Shares
683 Capital Management, LLC $35,548,200 290,000 0.37% Shares
Nuveen, LLC $34,823,140 284,085 0.37% Shares
Stephens Investment Management Group LLC $34,546,967 281,832 0.36% Shares
BNP PARIBAS ASSET MANAGEMENT Holding S.A. $31,867,368 259,972 0.34% Shares
Eagle Health Investments LP $30,439,311 248,322 0.32% Shares
NEXTBio Capital Management LP $26,885,839 219,333 0.28% Shares
SEGALL BRYANT & HAMILL, LLC $26,320,868 214,724 0.28% Shares
SEB Asset Management AB $25,737,215 209,963 0.27% Shares
Public Sector Pension Investment Board $25,458,395 207,688 0.27% Shares
CITIGROUP INC $24,352,723 198,668 0.26% Shares
JPMORGAN CHASE & CO $22,569,540 183,098 0.24% Shares
DIMENSIONAL FUND ADVISORS LP $21,836,172 178,152 0.23% Shares
Affinity Asset Advisors, LLC $21,099,083 172,125 0.22% Shares
Fisher Asset Management, LLC $20,902,831 170,524 0.22% Shares

Show all 367 institutional owners →

Activists & 5%+ owners 1 position

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Lilly Ventures Fund I, LLC, LV Management Group, LLC, S. Edward Torres, Steven E. Hall, Ph.D., Armen B. Shanafelt, Ph.D. ×2 filings June 8, 2020 · Initial filing · SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 20 insiders · 10 officers · 11 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
PATEL DINESH V PH D President and CEO Sept. 10, 2026 M 522,968 0 14 $-60,578,256
Asif Ali Chief Financial Officer Sept. 30, 2026 M 59,003 0 7 $-15,627,745
Donald A. Kalkofen Chief Financial Officer Feb. 15, 2022 A 18,521 0 0 $0
Thomas P. O'Neil Chief Financial Officer Aug. 15, 2018 A 30,560 0 0 $0
Arturo Molina MD Chief Medical Officer March 26, 2026 M 84,115 0 6 $-4,491,766
Suneel Gupta Chief Development Officer Nov. 26, 2024 M 267,433 0 0 $0
David Y Liu Chief R&D Strategy Officer Nov. 16, 2022 M 167,590 0 0 $0
Samuel R Saks Chief Medical Officer Feb. 26, 2021 A 14,000 0 0 $0
Richard S Shame Chief Medical Officer Feb. 28, 2019 A 32,021 0 0 $0
William A Hodder Sr. VP - Corporate Development Oct. 11, 2016 A · 0 0 $0
William D. Waddill Director June 23, 2026 M 7,825 0 6 $-5,580,420
Bryan Giraudo Director May 7, 2026 M 12,695 0 4 $-5,918,880
Harold E Selick Director March 26, 2026 M 60,845 0 1 $-2,520,000
Lewis T Williams Director Feb. 17, 2026 M 7,825 0 1 $-1,483,560
Sarah A O'Dowd Director Jan. 2, 2026 A 7,825 0 0 $0
Daniel N Swisher JR Director Oct. 26, 2023 A · 0 0 $0
Sarah B. Noonberg Director Jan. 16, 2023 A 0 0 0 $0
Chaitan Khosla PHD Director Aug. 11, 2020 M 0 0 0 $0
Armen Shanafelt Director May 29, 2018 A 2,099,482 0 0 $0
Julie Papanek Director May 25, 2017 A 2,453,255 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 56 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
PSCH · Invesco Exchange-Traded Fund Trust … 4.91% 62,279 SH Oct. 1, 2026 Daily
XSMO · Invesco Exchange-Traded Fund Trust 2.71% 551,491 SH Oct. 1, 2026 Daily
PBE · Invesco Exchange-Traded Fund Trust 2.59% 77,923 SH Oct. 1, 2026 Daily
RZG · Invesco Exchange-Traded Fund Trust 2.02% 17,092 SH Oct. 1, 2026 Daily
BBP · ETFis Series Trust I 1.71% 12,363 NS July 31, 2026 N-PORT
VAMO · Cambria ETF Trust 1.00% 7,935 NS July 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.88% 31,902 NS July 31, 2026 N-PORT
VIOG · VANGUARD ADMIRAL FUNDS 0.81% 71,955 SH Aug. 19, 2026 Daily
IBB · iShares Trust 0.66% 466,476 SH Sept. 11, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.60% 4,579 SH Oct. 1, 2026 Daily
IWO · iShares Trust 0.59% 579,401 SH Sept. 11, 2026 Daily
QVMS · Invesco Exchange-Traded Fund Trust … 0.56% 9,298 SH Oct. 1, 2026 Daily
ESSC · Strategy Shares 0.55% 1,449 NS July 31, 2026 N-PORT
VTWG · VANGUARD SCOTTSDALE FUNDS 0.44% 65,879 SH Aug. 19, 2026 Daily
VIOO · VANGUARD ADMIRAL FUNDS 0.40% 211,363 SH Aug. 19, 2026 Daily
JPSE · J.P. Morgan Exchange-Traded Fund Tr… 0.39% 16,778 NS July 31, 2026 N-PORT
BKSE · BNY Mellon ETF Trust 0.36% 2,314 NS July 31, 2026 N-PORT
FNY · First Trust Exchange-Traded AlphaDE… 0.35% 14,976 NS July 31, 2026 N-PORT
IWM · iShares Trust 0.29% 1,572,745 SH Sept. 11, 2026 Daily
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.28% 14,392 NS July 31, 2026 N-PORT
RSSL · Global X Funds 0.27% 29,469 NS July 31, 2026 N-PORT
PWS · Pacer Funds Trust 0.25% 436 NS July 31, 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0.23% 354,172 SH Aug. 19, 2026 Daily
ROSC · Lattice Strategies Trust 0.23% 1,028 NS July 31, 2026 N-PORT
VBK · VANGUARD INDEX FUNDS 0.22% 851,812 SH Aug. 19, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.17% 27,056 SH Aug. 19, 2026 Daily
FNX · First Trust Exchange-Traded AlphaDE… 0.17% 16,805 NS July 31, 2026 N-PORT
ESUM · Strategy Shares 0.17% 2,228 NS July 31, 2026 N-PORT
ESML · iShares Trust 0.13% 24,877 SH Sept. 11, 2026 Daily
ISCG · iShares Trust 0.11% 7,049 SH Sept. 11, 2026 Daily
FAD · First Trust Exchange-Traded AlphaDE… 0.11% 4,495 NS July 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.10% 24,256 NS July 31, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.09% 17,937 SH Oct. 1, 2026 Daily
VB · VANGUARD INDEX FUNDS 0.09% 1,475,028 SH Aug. 19, 2026 Daily
VHT · VANGUARD WORLD FUND 0.09% 153,362 SH Aug. 19, 2026 Daily
SMDX · Tidal Trust III 0.08% 772 NS July 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.08% 693,286 SH Aug. 19, 2026 Daily
WSML · iShares Trust 0.07% 3,201 SH Sept. 11, 2026 Daily
RWJ · Invesco Exchange-Traded Fund Trust … 0.02% 2,464 SH Oct. 1, 2026 Daily
DCOR · Dimensional ETF Trust 0.01% 3,216 NS July 31, 2026 N-PORT
ITOT · iShares Trust 0.01% 78,521 SH Sept. 11, 2026 Daily
IWV · iShares Trust 0.01% 16,255 SH Sept. 11, 2026 Daily
TILT · FlexShares Trust 0.01% 1,782 NS July 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.01% 2,045,389 SH Aug. 19, 2026 Daily
VT · VANGUARD INTERNATIONAL EQUITY INDEX… 0.01% 49,344 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.01% 5,067 SH Aug. 19, 2026 Daily
ESGV · VANGUARD WORLD FUND 0.01% 13,583 SH Aug. 19, 2026 Daily
DFAS · Dimensional ETF Trust 0.00% 2,599 NS July 31, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.00% 5,700 NS July 31, 2026 N-PORT
IJR · iShares Trust · 3,688,949 SH Sept. 10, 2026 Daily
IJT · iShares Trust · 571,914 SH Sept. 9, 2026 Daily
XJR · iShares Trust · 8,347 SH Aug. 31, 2026 Daily
ISCB · iShares Trust · 2,384 SH Sept. 11, 2026 Daily
ISCV · iShares Trust · 6,767 SH Sept. 11, 2026 Daily
SMLF · iShares Trust · 28,109 SH Sept. 11, 2026 Daily
SMMV · iShares Trust · 10,763 SH Sept. 1, 2026 Daily

PTGX Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 20 analysts BUY
Median target $171.00 +22.1%
7 35.0% Strong Buy
12 60.0% Buy
1 5.0% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

13 analysts · 2026-09-20

Mean target $174.69 +24.7%

← Below all targets Current price $140.06
Low$149.00 Mean$174.69 High$225.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
PTGX $5.47B -42.6 -89.4% -282.8% -20.3% ·
KRYS $7.20B 36.0 33.9% 52.6% 18.1% ·
ARWR $4.68B -3449.0 23258.2% -0.20% -0.50% ·
CYTK $7.81B -9.7 376.6% -891.6% 152.7% ·
KYMR $6.33B -21.1 -16.7% -794.0% -24.4% ·
PCVX $6.05B -8.2 · · -26.6% ·
TGTX $4.63B 10.8 87.3% 72.6% 96.7% ·
PRAX $7.43B -21.9 249.5% · -47.3% ·

Latest News Recent headlines mentioning this company

23
Protagonist Therapeutics Inc. (PTGX): Billionaire Tom Steyer Likes Upside Potential of This Stock Yahoo Finance · 5 months ago Do Protagonist Therapeutics’ (PTGX) Derisked Drugs Have Blockbuster Potential? Yahoo Finance · 6 months ago

Trading Signals Recent buy/sell signals with entry price and risk/reward ratio

25
BLUECHIP_DIP Stopped out Jun 1
risk 1 reward 5.00
entry $98.42 R:R 5.00
BOUNCE_UP Stopped out Dec 18
risk 1 reward 2.00
entry $88.31 R:R 2.00

No open signal right now — no card is filled, and that's honest.

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

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Source: SEC 10-Q filed Aug 5, 2026