Insider at

04

Insider transactions

05
0 buys (P) 9 sells (S) Net: $-2,693,581 + 62 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

62 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
June 30, 2026 QURE S 10b5-1 17,060 $46.43 $792,096 25,996 Direct -39.62% Disposed -50.3% (price as of 2026-10-06)
June 30, 2026 QURE S 10b5-1 4,107 $46.49 $190,934 25,996 Direct -13.64% Disposed -50.4% (price as of 2026-10-06)
June 17, 2026 QURE S 10b5-1 5,295 $42.57 $225,408 25,996 Direct -16.92% Disposed -45.8% (price as of 2026-10-06)
June 11, 2026 QURE S 1,993 $27.06 $53,931 25,996 Direct -7.12% Disposed -14.8% (price as of 2026-10-06)
June 3, 2026 QURE S 10b5-1 2,645 $30.01 $79,376 20,439 Direct -11.46% Disposed -23.2% (price as of 2026-10-06)
Jan. 9, 2026 QURE S 10b5-1 6,390 $27.28 $174,319 20,439 Direct -23.82% Disposed -15.5% (price as of 2026-10-06)
Nov. 4, 2025 QURE S 10b5-1 17,810 $30.33 $540,177 20,439 Direct -46.56% Disposed -24.0% (price as of 2026-10-06)
Nov. 4, 2025 QURE S 10b5-1 11,000 $30.34 $333,740 20,439 Direct -34.99% Disposed -24.0% (price as of 2026-10-06)
Nov. 4, 2025 QURE S 10b5-1 10,000 $30.36 $303,600 20,439 Direct -32.85% Disposed -24.0% (price as of 2026-10-06)
June 20, 2025 QURE S 2,112 $14.45 $30,518 20,439 Direct -9.37% Disposed 59.6% (price as of 2026-10-06)
June 13, 2024 QURE S 2,218 $5.16 $11,445 6,501 Direct -25.44% Disposed 346.9% (price as of 2026-10-06)
June 16, 2023 QURE S 2,280 $18.93 $43,160 34,119 Direct -6.26% Disposed 21.8% (price as of 2026-10-06)
Feb. 27, 2023 QURE S 384 $19.99 $7,676 27,699 Direct -1.37% Disposed 15.4% (price as of 2026-10-06)
Feb. 28, 2022 QURE S 600 $16.76 $10,056 19,003 Direct -3.06% Disposed 37.6% (price as of 2026-10-06)
March 2, 2021 QURE S 504 $37.60 $18,950 18,069 Direct -2.71% Disposed -38.7% (price as of 2026-10-06)
Jan. 28, 2020 QURE S 806 $62.20 $50,133 14,128 Direct -5.40% Disposed -62.9% (price as of 2026-10-06)
Jan. 28, 2019 QURE S 1,210 $31.31 $37,885 14,934 Direct -7.50% Disposed -26.3% (price as of 2026-10-06)
Jan. 29, 2018 QURE S 2,878 $18.53 $53,329 12,914 Direct -18.22% Disposed 24.4% (price as of 2026-10-06)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
June 30, 2026 QURE Stock Option (Right to Buy) Ordinary Shares (17,060) $20.18 June 13, 2033 17,060 Disposed
June 30, 2026 QURE Stock Option (Right to Buy) Ordinary Shares (4,107) $37.00 Feb. 25, 2031 4,107 Disposed
June 17, 2026 QURE Stock Option (Right to Buy) Ordinary Shares (5,295) $31.71 Jan. 25, 2029 5,295 Disposed
June 10, 2026 QURE Stock Option (Right to Buy) Ordinary Shares (13,980) $26.82 June 10, 2036 13,980 Acquired
June 3, 2026 QURE Stock Option (Right to Buy) Ordinary Shares (2,645) $16.04 Feb. 24, 2032 2,645 Disposed
Jan. 9, 2026 QURE Stock Option (Right to Buy) Ordinary Shares (6,390) $19.39 Jan. 26, 2028 6,390 Disposed
Jan. 2, 2026 DYAI Restricted Stock Unit Common Stock (21,552) · · 21,552 Disposed
Jan. 2, 2026 DYAI Stock Option Common Stock (67,500) $0.94 Jan. 2, 2036 67,500 Acquired
Jan. 2, 2026 DYAI Restricted Stock Unit Common Stock (39,894) · · 39,894 Acquired
Nov. 4, 2025 QURE Stock Option (Right to Buy) Ordinary Shares (17,810) $14.08 June 15, 2032 17,810 Disposed
Nov. 4, 2025 QURE Stock Option (Right to Buy) Ordinary Shares (11,000) $5.37 Jan. 27, 2027 11,000 Disposed
Nov. 4, 2025 QURE Stock Option (Right to Buy) Ordinary Shares (10,000) $7.37 June 29, 2027 10,000 Disposed
June 11, 2025 QURE Stock Option (Right to Buy) Ordinary Shares (15,630) $16.22 June 11, 2035 15,630 Acquired
March 5, 2025 DYAI Stock Option Common Stock $1.33 March 31, 2025 7,500 Disposed
March 5, 2025 DYAI Stock Option Common Stock $1.33 March 31, 2025 22,500 Disposed
Jan. 2, 2025 DYAI Restricted Stock Unit Common Stock (23,585) · · 23,585 Disposed
Jan. 2, 2025 DYAI Stock Option Common Stock (67,500) $1.74 Jan. 2, 2035 67,500 Acquired
Jan. 2, 2025 DYAI Restricted Stock Unit Common Stock (21,552) · · 21,552 Acquired
June 19, 2024 QURE Stock Option (Right to Buy) Ordinary Shares (15,840) $4.57 June 19, 2034 15,840 Acquired
Jan. 3, 2024 DYAI Restricted Stock Unit Common Stock (27,174) · · 27,174 Disposed
Jan. 2, 2024 DYAI Stock Option Common Stock (67,500) $1.59 Jan. 2, 2034 67,500 Acquired
Jan. 2, 2024 DYAI Restricted Stock Unit Common Stock (23,585) · · 23,585 Acquired
June 13, 2023 QURE Stock Option (Right to Buy) Ordinary Shares (17,060) $20.18 June 13, 2033 17,060 Acquired
Jan. 3, 2023 DYAI Stock Option Common Stock (52,500) $1.38 Jan. 2, 2033 52,500 Acquired
Jan. 3, 2023 DYAI Restricted Stock Unit Common Stock (27,174) · · 27,174 Acquired
June 15, 2022 QURE Stock Option (Right to Buy) Ordinary Shares (17,810) $14.08 June 15, 2032 17,810 Acquired
June 10, 2022 DYAI Stock Option Common Stock (25,000) $2.60 June 9, 2032 25,000 Acquired
Feb. 24, 2022 QURE Stock Option (Right to Buy) Ordinary Shares (2,645) $16.04 Feb. 24, 2032 2,645 Acquired
Jan. 3, 2022 DYAI Stock Option Common Stock (52,500) $4.81 Jan. 2, 2032 52,500 Acquired
Feb. 25, 2021 QURE Stock Option (Right to Buy) Ordinary Shares (4,107) $37.00 Feb. 25, 2031 4,107 Acquired
Jan. 4, 2021 DYAI Stock Option Common Stock (52,500) $5.16 Jan. 3, 2031 52,500 Acquired
Feb. 27, 2020 QURE Stock Option (Right to Buy) Ordinary Shares (3,620) $51.81 Feb. 27, 2030 3,620 Acquired
Jan. 2, 2020 DYAI Stock Option Common Stock (75,000) $5.27 Jan. 1, 2030 75,000 Acquired
June 25, 2019 DYAI Stock Option Common Stock (25,000) $5.83 June 24, 2029 25,000 Acquired
Jan. 25, 2019 QURE Stock Option (Right to Buy) Ordinary Shares (5,295) $31.71 Jan. 25, 2029 5,295 Acquired
Jan. 26, 2018 QURE Stock Option (Right to Buy) Ordinary Shares (6,390) $19.39 Jan. 26, 2028 6,390 Acquired
Jan. 27, 2017 QURE Restricted Stock Units Ordinary Shares (11,000) $0.00 · 11,000 Acquired
Jan. 27, 2017 QURE Stock Option (Right to Buy) Ordinary Shares (11,000) $5.37 Jan. 27, 2027 11,000 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 29 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Feb. 13, 2019 DYAI Common Stock 72,707 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (18,750) 18,750 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (14,062) 14,062 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (14,062) 14,062 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (14,062) 14,062 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (14,062) 14,062 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (12,500) 12,500 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (9,375) 9,375 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (9,375) 9,375 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (9,375) 9,375 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (9,375) 9,375 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (12,500) 12,500 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (9,375) 9,375 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (9,375) 9,375 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (9,375) 9,375 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (9,375) 9,375 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (7,500) 7,500 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (22,500) 22,500 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (6,250) 6,250 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (4,688) 4,688 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (4,687) 4,687 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (4,688) 4,688 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (4,687) 4,687 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (6,250) 6,250 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (4,688) 4,688 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (4,687) 4,687 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (4,688) 4,688 Direct
Feb. 13, 2019 DYAI Stock Option→ Common Stock (4,687) 4,687 Direct
Jan. 10, 2017 QURE Stock Option (right to buy)→ Ordinary Shares (10,000) 10,000 Direct