Insider at

04

Insider transactions

05
0 buys (P) 28 sells (S) Net: $-3,772,795 + 26 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

26 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
March 6, 2026 MDGL S 646 $431.94 $279,033 13,826 Direct -4.46% Disposed 15.6% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 40 $425.08 $17,003 13,786 Direct -0.29% Disposed 17.5% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 420 $426.86 $179,281 13,366 Direct -3.05% Disposed 17.0% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 80 $427.84 $34,227 13,286 Direct -0.60% Disposed 16.7% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 160 $429.00 $68,640 13,126 Direct -1.20% Disposed 16.4% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 40 $429.58 $17,183 13,086 Direct -0.30% Disposed 16.3% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 120 $430.90 $51,708 12,966 Direct -0.92% Disposed 15.9% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 116 $432.56 $50,177 12,850 Direct -0.89% Disposed 15.5% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 160 $434.20 $69,472 12,690 Direct -1.25% Disposed 15.0% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 80 $435.32 $34,826 12,610 Direct -0.63% Disposed 14.7% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 80 $436.69 $34,935 12,530 Direct -0.63% Disposed 14.4% (price as of 2026-10-02)
March 6, 2026 MDGL S 10b5-1 40 $437.65 $17,506 12,490 Direct -0.32% Disposed 14.1% (price as of 2026-10-02)
March 2, 2026 MDGL S 1,183 $427.21 $505,389 9,257 Direct -11.33% Disposed 16.9% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 320 $570.39 $182,525 14,293 Direct -2.19% Disposed -12.4% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 410 $571.99 $234,516 13,883 Direct -2.87% Disposed -12.7% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 354 $573.02 $202,849 13,529 Direct -2.55% Disposed -12.8% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 717 $574.00 $411,558 12,812 Direct -5.30% Disposed -13.0% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 120 $574.95 $68,994 12,692 Direct -0.94% Disposed -13.1% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 240 $576.15 $138,276 12,452 Direct -1.89% Disposed -13.3% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 320 $577.81 $184,899 12,132 Direct -2.57% Disposed -13.6% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 258 $578.83 $149,338 11,874 Direct -2.13% Disposed -13.7% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 480 $579.85 $278,328 11,394 Direct -4.04% Disposed -13.9% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 240 $585.44 $140,506 11,154 Direct -2.11% Disposed -14.7% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 240 $587.85 $141,084 10,914 Direct -2.15% Disposed -15.0% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 160 $589.65 $94,344 10,754 Direct -1.47% Disposed -15.3% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 160 $590.37 $94,459 10,594 Direct -1.49% Disposed -15.4% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 74 $595.20 $44,045 10,520 Direct -0.70% Disposed -16.1% (price as of 2026-10-02)
Dec. 2, 2025 MDGL S 10b5-1 80 $596.18 $47,694 10,440 Direct -0.76% Disposed -16.2% (price as of 2026-10-02)
March 10, 2025 MDGL S 10b5-1 258 $323.04 $83,344 10,440 Direct -2.41% Disposed 54.6% (price as of 2026-10-02)
March 3, 2025 MDGL S 1,187 $325.89 $386,831 7,688 Direct -13.37% Disposed 53.2% (price as of 2026-10-02)
March 3, 2025 MDGL S 10b5-1 774 $323.54 $250,420 6,914 Direct -10.07% Disposed 54.4% (price as of 2026-10-02)
Oct. 14, 2022 RARE S 10b5-1 1,629 $40.16 $65,421 66,695 Direct -2.38% Disposed -62.1% (price as of 2026-10-02)
Oct. 12, 2022 RARE S 3,484 $38.22 $133,158 68,324 Direct -4.85% Disposed -60.2% (price as of 2026-10-02)
March 3, 2022 RARE S 10b5-1 420 $64.55 $27,111 51,808 Direct -0.80% Disposed -76.4% (price as of 2026-10-02)
March 1, 2022 RARE S 534 $66.62 $35,575 38,228 Direct -1.38% Disposed -77.2% (price as of 2026-10-02)
Oct. 14, 2021 RARE S 10b5-1 3,261 $81.16 $264,663 38,762 Direct -7.76% Disposed -81.2% (price as of 2026-10-02)
Oct. 12, 2021 RARE S 3,477 $82.79 $287,861 42,023 Direct -7.64% Disposed -81.6% (price as of 2026-10-02)
Sept. 29, 2020 PRLD P 10,000 $19.00 $190,000 10,000 Direct · Acquired -80.7% (price as of 2026-10-02)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
March 4, 2026 MDGL Stock Option (Right to Buy) Common Stock (6,519) $434.80 March 4, 2036 6,519 Acquired
Jan. 2, 2026 ORIC Stock Option (right to buy) Common Stock (40,000) $8.17 Jan. 1, 2036 40,000 Acquired
Dec. 2, 2025 MDGL Stock Option (Right to Buy) Common Stock (4,173) $251.63 March 1, 2034 4,173 Disposed
June 12, 2025 PRLD Director Stock Option (Right to Buy) Common Stock (38,000) $1.04 June 11, 2035 38,000 Acquired
March 5, 2025 MDGL Stock Option (Right to Buy) Common Stock (6,374) $347.28 March 5, 2035 6,374 Acquired
Jan. 2, 2025 ORIC Stock Option (right to buy) Common Stock (35,000) $8.26 Jan. 1, 2035 35,000 Acquired
June 14, 2024 PRLD Director Stock Option (Right to Buy) Common Stock (23,500) $3.90 June 13, 2034 23,500 Acquired
June 12, 2024 ORIC Stock Option (right to buy) Common Stock (25,600) $7.90 June 11, 2034 25,600 Acquired
June 16, 2023 PRLD Director Stock Option (Right to Buy) Common Stock (23,500) $5.56 June 15, 2033 23,500 Acquired
June 14, 2023 ORIC Stock Option (right to buy) Common Stock (20,500) $6.33 June 13, 2033 20,500 Acquired
June 17, 2022 PRLD Director Stock Option (Right to Buy) Common Stock (34,300) $4.74 June 16, 2032 34,300 Acquired
June 17, 2022 ORIC Stock Option (right to buy) Common Stock (53,700) $3.75 June 16, 2032 53,700 Acquired
March 1, 2022 RARE Stock Option (Right to Buy) Common Stock (24,900) $67.37 March 1, 2032 24,900 Acquired
June 18, 2021 PRLD Director Stock Option (Right to Buy) Common Stock (23,344) $31.02 June 17, 2031 23,344 Acquired
June 16, 2021 ORIC Stock Option (right to buy) Common Stock (16,625) $19.03 June 15, 2031 16,625 Acquired
March 1, 2021 RARE Stock Option (Right to Buy) Common Stock (11,000) $142.47 March 1, 2031 11,000 Acquired
Oct. 12, 2020 RARE Stock Option (Right to Buy) Common Stock (40,000) $95.50 Oct. 12, 2030 40,000 Acquired
Sept. 24, 2020 PRLD Director Stock Option (right to buy) Common Stock (3,458) $19.00 Sept. 23, 2030 3,458 Acquired
April 23, 2020 ORIC Stock Option (right to buy) Common Stock (33,250) $16.00 April 22, 2030 33,250 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 5 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
March 21, 2024 MDGL Common Stock 8,875 Direct
March 21, 2024 MDGL Stock Option (Right to Buy)→ Common Stock (13,353) 13,353 Direct
March 21, 2024 MDGL Market Stock Unit→ Common Stock (8,875) 8,875 Direct
Sept. 24, 2020 PRLD Director→ Common Stock (43,230) 43,230 Direct
April 23, 2020 ORIC No securities of the Issuer are beneficially owned. 0 Direct

Compensation (DEF 14A)

08

Matched by name from proxy statements (DEF 14A) — verify against the filing.

RARE

EVP
Fiscal yearSalaryBonusStock awards Option awardsNon-equity incentivePension changeOtherTotal
2022 $607,346 · $2,928,368 $892,550 · · $8,492 $4,436,756
2021 $561,539 · $1,653,212 $866,427 $247,523 · $3,173 $3,331,874
2020 $116,346 $100,000 $3,820,000 $2,084,296 · · · $6,120,642

Figures from the Summary Compensation Table of the company's proxy statement (DEF 14A). Compensation is not a recommendation.