PRLD Prelude Therapeutics Incorporated - Common Stock
$5.80
Price · Aug 19, 2026
Fundamentals as of Aug 11, 2026
52W Range
$1–$6
98% of range
Analyst Rating
BUY
9 analysts
Price Target
$8
+38% upside
P/E (TTM)
-2.2
ROE
-137.7%
Net Profit Margin
-819.6%
PRLD Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$5.80
Market Cap
—
P/E (TTM)
-2.2
EPS (TTM)
$-1.29
Revenue (TTM)
$12M
Div Yield
—
ROE
-137.7%
Debt/Equity
—
52W Range
$1 – $6
PRLD Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
$12M
2024-12-31
→
2025-12-31
EPS
$-1.29
2021-12-31
→
2025-12-31
Free Cash Flow
$-56M
2020-12-31
→
2025-12-31
Margins
-819.6%
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
PRLD
Peer Median
P/E (TTM)
-2.2
19.6
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
PRLD
Peer Median
Operating Margin
-861.3%
—
Net Profit Margin
-819.6%
-298.0%
ROA
-62.8%
-56.6%
ROE
-137.7%
-70.8%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
PRLD
Peer Median
Current Ratio
2.0
5.2
Quick Ratio
1.9
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
PRLD
Peer Median
Revenue YoY
73.4%
—
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
PRLD
Peer Median
PRLD Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
9 analysts
- Strong Buy 3 33.3%
- Buy 5 55.6%
- Hold 1 11.1%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
3 analysts · 2026-08-13
Median
$8.00
← Below all targets
$5.80
Low
$6.00
High
$10.00
Median target
$8.00
+37.9%
Mean target
$8.00
+37.9%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.03%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| March 31, 2026 | $-0.13 | $-0.25 | 0.12% |
| Dec. 31, 2025 | $-0.20 | $-0.03 | -0.17% |
| Sept. 30, 2025 | $-0.26 | $-0.37 | 0.11% |
| June 30, 2025 | $-0.41 | $-0.45 | 0.04% |
| March 31, 2025 | $-0.42 | $-0.48 | 0.06% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| PRLD | — | -2.2 | 73.4% | -819.6% | -137.7% | — |
| PRME | $626M | -2.6 | 55.3% | -4342.4% | -221.4% | — |
| ARTV | — | -1.3 | -99.2% | — | — | — |
| EIKN | — | — | — | — | — | — |
| OVID | $212M | -4.0 | 1181.3% | -240.1% | -18.7% | — |
| KYTX | $568M | -2.6 | — | — | -77.4% | — |
| VSTM | $600M | -2.6 | 209.1% | -677.6% | -449.2% | — |
| ZURA | — | — | — | — | — | — |
| EVMN | $540M | -1.5 | 85.7% | -529.8% | -401.2% | — |
| CCCC | $185M | -1.5 | 1.0% | -292.1% | -48.8% | — |
| MPLT | $773M | -0.9 | — | — | -151.1% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 13
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Revenue | $12M | $7M | |
| R&D Expense | $94M | $118M | |
| SG&A Expense | $22M | $29M | |
| Operating Expenses | $117M | $147M | |
| Operating Income | $-105M | $-140M | |
| Other Non-op | $5M | $13M | |
| Income Tax | $0 | $0 | |
| Net Income | $-99M | $-127M | |
| EPS (Basic) | $-1.29 | $-1.68 | |
| EPS (Diluted) | $-1.29 | $-1.68 | |
| Shares (Basic) | 76,956,194 | 75,805,840 | |
| Shares (Diluted) | 76,956,194 | 75,805,840 | |
| EBITDA | $-103M | $-138M |
Balance Sheet 18
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Cash & Equivalents | $35M | $12M | |
| Short-term Investments | $68M | $121M | |
| Prepaid Expense | $2M | $2M | |
| Current Assets | $106M | $136M | |
| PP&E (Net) | $5M | $7M | |
| PP&E (Gross) | $12M | $12M | |
| Accum. Depreciation | $7M | $5M | |
| Total Assets | $141M | $176M | |
| Accounts Payable | $4M | $8M | |
| Accrued Liabilities | $13M | $15M | |
| Current Liabilities | $53M | $26M | |
| Capital Leases | $15M | $15M | |
| Other Non-current Liabilities | $3M | $3M | |
| Total Liabilities | $73M | $44M | |
| Retained Earnings | $-683M | $-584M | |
| AOCI | $8.0K | $35.0K | |
| Stockholders' Equity | $69M | $131M | |
| Liabilities + Equity | $141M | $176M |
Cash Flow 11
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| D&A | $2M | $2M | |
| Stock-based Comp | $12M | $21M | |
| Restructuring | $1M | · | |
| Other Non-cash | $30M | $1M | |
| Operating Cash Flow | $-56M | $-103M | |
| CapEx | $67.0K | $764.0K | |
| Investing Cash Flow | $53M | $90M | |
| Financing Cash Flow | $25M | $-120.0K | |
| Net Change in Cash | $22M | $-13M | |
| Taxes Paid | $0 | $0 | |
| Free Cash Flow | $-56M | $-104M |
Profitability 5
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Operating Margin | -861.3% | -1995.9% | |
| Net Margin | -819.6% | -1816.8% | |
| EBITDA Margin | -847.2% | -1970.6% | |
| ROA | -62.8% | -56.1% | |
| ROE | -137.7% | -88.3% |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Current Ratio | 2.0 | 5.3 | |
| Quick Ratio | 1.9 | 5.2 |
Efficiency 1
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Asset Turnover | 0.1 | 0.0 |
Growth Rates 1
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Revenue YoY | 73.4% | · |
Valuation (TTM) 4
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Revenue TTM | $12M | $7M | |
| Net Income TTM | $-99M | $-127M | |
| P/E | -2.2 | -0.8 | |
| Earnings Yield | -44.5% | -131.8% |
Income Statement 12
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 |
|---|---|---|---|---|---|---|---|---|---|
| Revenue | $6M | $5M | $6M | $6M | $0 | $0 | $4M | $3M | |
| R&D Expense | $16M | $14M | $18M | $22M | $26M | $29M | $32M | $29M | |
| SG&A Expense | $5M | $5M | $5M | $5M | $6M | $6M | $6M | $8M | |
| Operating Expenses | $21M | $19M | $23M | $27M | $32M | $35M | $38M | $37M | |
| Operating Income | $-15M | $-14M | $-17M | $-20M | $-32M | $-35M | $-34M | $-34M | |
| Other Non-op | $2M | $4M | $891.0K | $693.0K | $963.0K | $3M | $5M | $2M | |
| Net Income | $-14M | $-10M | $-16M | $-20M | $-31M | $-32M | $-29M | $-32M | |
| EPS (Basic) | $-0.14 | $-0.13 | $-0.20 | $-0.26 | $-0.41 | $-0.42 | $-0.37 | $-0.43 | |
| EPS (Diluted) | $-0.14 | $-0.13 | $-0.20 | $-0.26 | $-0.41 | $-0.42 | $-0.37 | $-0.43 | |
| Shares (Basic) | 98,388,593 | 82,519,981 | -151,156,365 | 76,132,337 | 75,993,941 | 75,986,281 | -151,548,215 | 75,855,949 | |
| Shares (Diluted) | 98,388,593 | 82,519,981 | -151,156,365 | 76,132,337 | 75,993,941 | 75,986,281 | -151,548,215 | 75,855,949 | |
| EBITDA | $-15M | $-14M | · | $-20M | $-32M | $-34M | · | $-34M |
Balance Sheet 18
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 |
|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $26M | $22M | $35M | $48M | $26M | $40M | $12M | $11M | |
| Short-term Investments | $125M | $60M | $68M | $7M | $47M | $59M | $121M | $142M | |
| Prepaid Expense | $3M | $3M | $2M | $3M | $4M | $3M | $2M | $3M | |
| Current Assets | $155M | $85M | $106M | $58M | $77M | $102M | $136M | $156M | |
| PP&E (Net) | $4M | $5M | $5M | $6M | $6M | $6M | $7M | $7M | |
| PP&E (Gross) | · | · | $12M | · | · | · | $12M | · | |
| Accum. Depreciation | · | · | $7M | · | · | · | $5M | · | |
| Total Assets | $189M | $120M | $141M | $95M | $115M | $141M | $176M | $197M | |
| Accounts Payable | $2M | $2M | $4M | $3M | $5M | $6M | $8M | $6M | |
| Accrued Liabilities | $8M | $6M | $13M | $13M | $13M | $11M | $15M | $14M | |
| Current Liabilities | $38M | $42M | $53M | $18M | $21M | $20M | $26M | $22M | |
| Capital Leases | $15M | $15M | $15M | $15M | $15M | $15M | $15M | $15M | |
| Other Non-current Liabilities | $3M | $3M | $3M | $3M | $3M | $3M | $3M | $3M | |
| Total Liabilities | $56M | $59M | $73M | $36M | $39M | $38M | $44M | $41M | |
| Retained Earnings | $-707M | $-693M | $-683M | $-667M | $-647M | $-616M | $-584M | $-555M | |
| AOCI | $-227.0K | $-41.0K | $8.0K | $2.0K | $-1.0K | $12.0K | $35.0K | $167.0K | |
| Stockholders' Equity | $134M | $60M | $69M | $59M | $76M | $103M | $131M | $156M | |
| Liabilities + Equity | $189M | $120M | $141M | $95M | $115M | $141M | $176M | $197M |
Cash Flow 10
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 |
|---|---|---|---|---|---|---|---|---|---|
| D&A | $353.0K | $391.0K | $418.0K | $425.0K | $433.0K | $435.0K | $489.0K | $405.0K | |
| Stock-based Comp | $2M | $2M | $2M | $2M | $4M | $4M | $4M | $6M | |
| Restructuring | $0 | $0 | $851.0K | $0 | · | · | · | · | |
| Other Non-cash | · | $-14M | · | · | · | $-6M | · | · | |
| Operating Cash Flow | $-16M | $-22M | $23M | $-19M | $-26M | $-34M | $-21M | $-27M | |
| CapEx | $0 | $0 | $0 | $0 | $20.0K | $47.0K | $53.0K | $63.0K | |
| Investing Cash Flow | $-66M | $8M | $-60M | $40M | $12M | $62M | $22M | $11M | |
| Financing Cash Flow | $86M | $-314.0K | $25M | $-5.0K | $37.0K | $-160.0K | $-34.0K | $-131.0K | |
| Net Change in Cash | $5M | $-14M | $-12M | $21M | $-15M | $28M | $1M | $-17M | |
| Free Cash Flow | · | $-22M | · | · | · | $-34M | · | · |
Profitability 5
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 |
|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -270.9% | -309.5% | · | -314.1% | · | · | · | -1145.9% | |
| Net Margin | -244.1% | -226.8% | · | -303.5% | · | · | · | -1075.7% | |
| EBITDA Margin | -270.9% | -301.0% | · | -314.1% | · | · | · | -1145.9% | |
| ROA | -9.2% | -8.0% | · | -13.5% | -18.4% | -16.5% | · | -14.2% | |
| ROE | -13.3% | -12.7% | · | -18.4% | -24.2% | -20.4% | · | -16.4% |
Liquidity & Solvency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 |
|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 4.1 | 2.0 | · | 3.2 | 3.7 | 5.2 | · | 7.0 | |
| Quick Ratio | 4.0 | 2.0 | · | 3.0 | 3.5 | 5.0 | · | 6.9 |
Efficiency 1
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 |
|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | 0.0 | · | · | · | 0.0 |
Valuation (TTM) 4
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 |
|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $17M | · | · | · | · | · | · | · | |
| Net Income TTM | $-75M | $-93M | · | $-115M | $-130M | $-131M | · | $-129M | |
| P/E | -5.7 | -2.8 | · | -0.9 | -0.5 | -0.4 | · | -1.2 | |
| Earnings Yield | -17.6% | -35.7% | · | -105.6% | -212.6% | -225.3% | · | -85.0% |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Revenue | $12M | $7M | — | — | — |
| Operating Margin % | -861.3% | -1995.9% | — | — | — |
| Net Income | $-99M | $-127M | $-122M | $-115M | $-112M |
| Diluted EPS | $-1.29 | $-1.68 | $-2.02 | $-2.44 | $-2.43 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Current Ratio | 2.0 | 5.3 | 10.8 | 9.4 | 15.4 |
| Quick Ratio | 1.9 | 5.2 | 10.7 | 9.3 | 15.2 |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Free Cash Flow | $-56M | $-104M | $-111M | $-87M | $-86M |
Latest News Recent headlines mentioning this company
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Institutional owners (13F) 86 filers · $247.5M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 43 (+32 vs prior Q) | 11 (+7 vs prior Q) | 21 (+2 vs prior Q) | 9 (-1 vs prior Q) | +18.1M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| ORBIMED ADVISORS LLC | $73,151,963 | 13,724,571 | 29.56% | Shares |
| BAKER BROS. ADVISORS LP | $53,959,982 | 10,123,824 | 21.80% | Shares |
| RA CAPITAL MANAGEMENT, L.P. | $34,516,451 | 6,475,882 | 13.95% | Shares |
| Soleus Capital Management, L.P. | $18,006,755 | 3,378,378 | 7.28% | Shares |
| Kynam Capital Management, LP | $12,872,414 | 2,415,087 | 5.20% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $10,710,342 | 2,009,445 | 4.33% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $5,435,705 | 1,019,832 | 2.20% | Shares |
| TWO SIGMA INVESTMENTS, LP | $5,294,657 | 993,369 | 2.14% | Shares |
| ADAR1 Capital Management, LLC | $4,801,797 | 900,900 | 1.94% | Shares |
| MILLENNIUM MANAGEMENT LLC | $4,503,813 | 844,993 | 1.82% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $4,083,286 | 766,095 | 1.65% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $3,751,819 | 703,768 | 1.52% | Shares |
| STATE STREET CORP | $2,285,435 | 428,787 | 0.92% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $1,518,442 | 284,886 | 0.61% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $1,498,796 | 281,200 | 0.61% | Shares |
| MORGAN STANLEY | $1,482,881 | 278,214 | 0.60% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1,033,594 | 193,920 | 0.42% | Shares |
| TWO SIGMA ADVISERS, LP | $688,170 | 237,300 | 0.28% | Shares |
| Connor, Clark & Lunn Investment Management Ltd. | $664,571 | 124,685 | 0.27% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $591,630 | 111,000 | 0.24% | Call option |
| VANGUARD GROUP INC | $456,402 | 157,380 | 0.18% | Shares |
| Hillsdale Investment Management Inc. | $433,862 | 81,400 | 0.18% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $360,425 | 67,622 | 0.15% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $343,785 | 64,500 | 0.14% | Shares |
| JANE STREET GROUP, LLC | $341,653 | 64,100 | 0.14% | Call option |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $339,521 | 63,700 | 0.14% | Put option |
| Squarepoint Ops LLC | $317,348 | 59,540 | 0.13% | Shares |
| BlackRock, Inc. | $271,505 | 50,939 | 0.11% | Shares |
| GOLDMAN SACHS GROUP INC | $265,199 | 49,756 | 0.11% | Shares |
| PANAGORA ASSET MANAGEMENT INC | $253,569 | 47,574 | 0.10% | Shares |
| Mariner, LLC | $241,241 | 45,261 | 0.10% | Shares |
| Nuveen, LLC | $197,333 | 37,023 | 0.08% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $176,594 | 33,132 | 0.07% | Shares |
| Cerity Partners LLC | $175,224 | 32,875 | 0.07% | Shares |
| State of Wyoming | $175,154 | 32,862 | 0.07% | Shares |
| CITADEL ADVISORS LLC | $166,829 | 31,300 | 0.07% | Put option |
| Graham Capital Management, L.P. | $158,674 | 29,770 | 0.06% | Shares |
| WELLS FARGO & COMPANY/MN | $134,982 | 25,325 | 0.05% | Shares |
| BANK OF AMERICA CORP /DE/ | $127,254 | 23,875 | 0.05% | Shares |
| RHUMBLINE ADVISERS | $117,649 | 22,074 | 0.05% | Shares |
| JANE STREET GROUP, LLC | $107,133 | 20,100 | 0.04% | Put option |
| Bank of New York Mellon Corp | $102,618 | 19,253 | 0.04% | Shares |
| Vanguard Global Advisers, LLC | $86,399 | 16,210 | 0.03% | Shares |
| CITADEL ADVISORS LLC | $85,813 | 16,100 | 0.03% | Call option |
| MARSHALL WACE, LLP | $83,845 | 15,731 | 0.03% | Shares |
| ExodusPoint Capital Management, LP | $82,482 | 15,475 | 0.03% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $75,686 | 14,200 | 0.03% | Shares |
| HSBC HOLDINGS PLC | $74,403 | 13,652 | 0.03% | Shares |
| MANGROVE PARTNERS IM, LLC | $71,166 | 13,352 | 0.03% | Shares |
| Qube Research & Technologies Ltd | $69,876 | 13,110 | 0.03% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $68,139 | 12,784 | 0.03% | Shares |
| BARCLAYS PLC | $66,811 | 12,535 | 0.03% | Shares |
| CITIGROUP INC | $60,927 | 11,431 | 0.02% | Shares |
| Invesco Ltd. | $59,008 | 11,071 | 0.02% | Shares |
| Spark Investment Management LLC | $56,498 | 10,600 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $55,922 | 10,492 | 0.02% | Shares |
| CITADEL ADVISORS LLC | $54,531 | 10,231 | 0.02% | Shares |
| ALLIANCEBERNSTEIN L.P. | $36,013 | 10,530 | 0.01% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $34,272 | 6,430 | 0.01% | Shares |
| FMR LLC | $30,003 | 5,629 | 0.01% | Shares |
| STRS OHIO | $29,315 | 5,500 | 0.01% | Shares |
| NORTHERN TRUST CORP | $23,154 | 4,344 | 0.01% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $21,874 | 4,104 | 0.01% | Shares |
| Nuveen Asset Management, LLC | $21,416 | 16,797 | 0.01% | Shares |
| GROUP ONE TRADING LLC | $20,824 | 3,907 | 0.01% | Shares |
| Legal & General Group Plc | $14,386 | 2,699 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $13,432 | 2,520 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $12,669 | 2,377 | 0.01% | Shares |
| Russell Investments Group, Ltd. | $11,832 | 2,220 | 0.00% | Shares |
| JPMORGAN CHASE & CO | $9,318 | 1,890 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $8,709 | 1,634 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $5,000 | 958 | 0.00% | Shares |
| Quarry LP | $4,024 | 755 | 0.00% | Shares |
| DEUTSCHE BANK AG\ | $3,950 | 741 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $3,253 | 611,359 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $2,308 | 433 | 0.00% | Shares |
| CWM, LLC | $1,960 | 573 | 0.00% | Shares |
| Fortitude Family Office, LLC | $1,226 | 230 | 0.00% | Shares |
| Sterling Capital Management LLC | $517 | 97 | 0.00% | Shares |
| UBS Group AG | $123 | 23 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $122 | 22,758 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $117 | 22 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $96 | 18 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $68 | 12,672 | 0.00% | Shares |
| MERCER GLOBAL ADVISORS INC /ADV | $27 | 5 | 0.00% | Shares |
| Optiver Holding B.V. | $21 | 4 | 0.00% | Shares |
Company insiders 15 insiders · 9 officers · 7 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Krishna Vaddi | CEO | Feb. 15, 2022 A | 1,053,519 | 0 | 0 | $0 |
| Laurent Chardonnet | Chief Financial Officer | March 21, 2022 A | 14,500 | 0 | 0 | $0 |
| Brian Piper | Chief Financial Officer | Aug. 25, 2021 M | 0 | 0 | 0 | $0 |
| Jane Huang | President, CMO | July 4, 2023 M | 30,353 | 0 | 0 | $0 |
| Andrew Combs | EVP, Head of Chemistry | April 1, 2022 M | 304,442 | 0 | 0 | $0 |
| Peggy Scherle | Chief Scientific Officer | Feb. 15, 2022 A | 172,920 | 0 | 0 | $0 |
| Deborah Morosini | EVP, Chief of Clinical Affairs | Feb. 15, 2022 A | 444 | 0 | 0 | $0 |
| David J Mauro | Chief Medical Officer | Oct. 5, 2021 M | 0 | 0 | 0 | $0 |
| Christopher Pierce | EVP and Chief of Business Oper | Sept. 2, 2021 M | 3,750 | 0 | 0 | $0 |
| Victor Sandor | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| Katina Dorton | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| David P Bonita | Director | June 9, 2026 A | — | 2 | 0 | $12,499,998 |
| Martin Babler | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| Paul A Friedman, M.D. | Director | June 9, 2026 A | 500,098 | 0 | 0 | $0 |
| Mardi Dier | Director | June 16, 2023 A | 10,000 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 2 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC, ORBIMED CAPITAL GP VI LLC, OrbiMed Genesis GP LLC, ORBIMED CAPITAL LLC ×4 filings | April 23, 2026 | 16.00% | Amendment | — | SEC |
| Baker Bros. Advisors LP, Baker Bros. Advisors (GP) LLC, Julian C. Baker, Felix J. Baker ×6 filings | April 22, 2026 | 15.50% | Amendment | Capital structure | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 13 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| OMFS · Invesco Exchange-Traded Self-Indexe… | 0.03% | 19,657 SH | Aug. 8, 2026 | Daily |
| IWC · iShares Trust | 0.03% | 93,079 SH | Aug. 8, 2026 | Daily |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0.01% | 29,931 SH | Aug. 8, 2026 | Daily |
| IWO · iShares Trust | 0.01% | 254,408 SH | Aug. 8, 2026 | Daily |
| IWM · iShares Trust | 0.00% | 644,659 SH | Aug. 8, 2026 | Daily |
| AVSC · AMERICAN CENTURY ETF TRUST | 0.00% | 13,637 NS | May 31, 2026 | N-PORT |
| DFSU · Dimensional ETF Trust | 0.00% | 3,323 NS | April 30, 2026 | N-PORT |
| DFAS · Dimensional ETF Trust | 0.00% | 7,414 NS | April 30, 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0.00% | 1,348 NS | April 30, 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0.00% | 458,355 SH | Aug. 8, 2026 | Daily |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 1,513,825 SH | Aug. 8, 2026 | Daily |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.00% | 160,484 SH | Aug. 8, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 3,505 SH | Aug. 8, 2026 | Daily |