Insider at

04

Insider transactions

05
0 buys (P) 0 sells (S) Net: $0 + 8 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

No open-market trades on record; showing all filings.

DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
June 17, 2026 GPCR A 39,453 · · 39,453 Direct · Acquired (price as of 2026-10-05)
June 23, 2025 GPCR A 51,804 · · 51,804 Direct · Acquired (price as of 2026-10-05)
June 25, 2024 GPCR A 37,500 · · 37,500 Direct · Acquired (price as of 2026-10-05)
June 9, 2021 GYRE A 14,000 · · 14,000 Direct · Acquired (price as of 2026-10-05)
July 1, 2020 GYRE A 1,703 · · 3,635 Direct +88.15% Acquired (price as of 2026-10-05)
June 11, 2020 GYRE A 5,000 · · 5,000 Direct · Acquired (price as of 2026-10-05)
April 1, 2020 GYRE A 1,932 · · 1,932 Direct · Acquired (price as of 2026-10-05)
Jan. 15, 2020 GYRE A 10,000 · · 10,000 Direct · Acquired (price as of 2026-10-05)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
June 17, 2026 GPCR Share Option (right to buy) Ordinary Shares · June 16, 2036 39,453 Acquired
June 23, 2025 GPCR Share Option (right to buy) Ordinary Shares · June 22, 2035 51,804 Acquired
June 25, 2024 GPCR Share Option (right to buy) Ordinary Shares · June 24, 2034 37,500 Acquired
June 9, 2021 GYRE Stock Option (Right to Buy) Common Stock (14,000) $4.55 June 9, 2031 14,000 Acquired
June 11, 2020 GYRE Stock Option (Right to Buy) Common Stock (5,000) $7.18 June 11, 2030 5,000 Acquired
Jan. 15, 2020 GYRE Stock Option (Right to Buy) Common Stock (10,000) $7.29 Jan. 15, 2030 10,000 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 1 holding

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Feb. 2, 2023 GPCR Stock option (right to buy)→ Ordinary Shares (80,000) 80,000 Direct