IONS Ionis Pharmaceuticals, Inc. - Common Stock
$58,28
Precio · Ago 18, 2026
Fundamentales a fecha de Jul 29, 2026
Rango 52S
$42–$87
37% of range
Calificación del Analista
BUY
31 analysts
Precio Objetivo
$89
+53% upside
P/E (TTM)
-24.5
ROE
-68.1%
Margen de Beneficio Neto
—
IONS Instantánea de la Acción Precio, capitalización bursátil, P/E, BPA, ROE, deuda/capital, rango de 52 semanas
Precio
$58.28
Capitalización Bursátil
$9.52B
P/E (TTM)
-24.5
BPA (TTM)
$-2.38
Ingresos (TTM)
—
Rendimiento div.
—
ROE
-68.1%
Deuda/Capital
3.6
Rango 52S
$42 – $87
IONS Gráfico del Precio de la Acción OHLCV diario con indicadores técnicos — desplace, amplíe y personalice su vista
Configure
Rendimiento a 10 años Tendencias de ingresos, beneficio neto, márgenes y BPA
Ingresos y Beneficio Neto
—
2016-12-31
→
2017-12-31
BPA
$-2.38
2016-12-31
→
2025-12-31
Flujo de caja libre
$-320M
2016-12-31
→
2025-12-31
Márgenes
—
Valoración Ratios P/E, P/S, P/B, EV/EBITDA: ¿está la acción cara o barata?
Métrica
Tendencia a 5 años
IONS
Mediana de Pares
P/E (TTM)
-24.5
16.0
P/S (TTM) (P/V (TTM))
10.1
32.5
P/B (P/C)
19.5
3.9
EV / EBITDA
-22.5
—
Price / FCF (Precio / FCF)
-29.7
—
Rentabilidad Márgenes brutos, operativos y netos; ROE, ROA, ROIC
Métrica
Tendencia a 5 años
IONS
Mediana de Pares
ROA
-11.7%
-22.2%
ROE
-68.1%
-37.6%
ROIC
-17.1%
—
Salud financiera Deuda, liquidez, solvencia — solidez del balance general
Métrica
Tendencia a 5 años
IONS
Mediana de Pares
Debt / Equity (Deuda / Patrimonio)
3.6
0.0
Current Ratio (Ratio corriente)
3.8
5.7
Quick Ratio (Ratio Rápido)
3.4
—
Crecimiento Crecimiento de ingresos, BPA y beneficio neto: interanual, CAGR a 3 años, CAGR a 5 años
Métrica
Tendencia a 5 años
IONS
Mediana de Pares
Eficiencia de capital Rotación de activos, rotación de inventario, rotación de cuentas por cobrar
Métrica
Tendencia a 5 años
IONS
Mediana de Pares
IONS Consenso de analistas Opiniones de analistas alcistas y bajistas, precio objetivo a 12 meses, potencial alcista
COMPRA
31 analistas
- Compra fuerte 8 25,8%
- Compra 17 54,8%
- Mantener 6 19,4%
- Venta 0 0,0%
- Venta fuerte 0 0,0%
Precio objetivo a 12 meses
21 analistas · 2026-08-18
Mediana
$90.00
← Por Debajo de Todos los Objetivos
$58.28
Mín
$66.00
Máx
$115.00
Objetivo mediano
$90.00
+54,4%
Objetivo medio
$89.33
+53,3%
Historial de Ganancias EPS real vs estimado, sorpresa %, tasa de aciertos, próxima fecha de resultados
Sorpresa Media
0.42%
| Período | EPS Actual | EPS est. | Sorpresa |
|---|---|---|---|
| 30 de junio de 2026 | $-0.69 | $-1.09 | 0.40% |
| 31 de marzo de 2026 | $-0.56 | $-0.93 | 0.37% |
| 31 de diciembre de 2025 | $-1.41 | $-1.35 | -0.06% |
| 30 de septiembre de 2025 | $-0.80 | $-1.26 | 0.46% |
| 30 de junio de 2025 | $0.70 | $-0.44 | 1.1% |
| 31 de marzo de 2025 | $-0.93 | $-1.14 | 0.21% |
Comparación de pares (subindustria GICS) Métricas clave frente a competidores del sector
| Ticker | Capitalización Bursátil | P/E | Ingresos interanuales | Margen Neto | ROE | Margen Bruto |
|---|---|---|---|---|---|---|
| IONS | $12.92B | -33.2 | — | — | -68.1% | — |
| APGE | $5.16B | -17.9 | — | — | — | — |
| PTGX | $5.47B | -42.6 | -89.4% | -282.8% | -20.3% | — |
| KYMR | $6.33B | -21.1 | -16.7% | -794.0% | -24.4% | — |
| KRYS | $7.20B | 36.0 | 33.9% | 52.6% | 18.1% | — |
| SYRE | $2.56B | 10.1 | -62.0% | — | -26.5% | — |
| PCVX | $6.05B | -8.2 | — | — | -26.6% | — |
| IMVT | $5.07B | -9.0 | 229.2% | — | -73.7% | — |
| IBRX | $2.00B | -5.2 | 668.3% | -310.2% | 71.0% | — |
Fundamentales Completos Todas las métricas por año — estado de resultados, balance general, flujo de caja
Estado de resultados 16
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | · | · | · | · | · | · | · | · | $508M | $347M | $284M | $214M | |
| Cost of Revenue | $16M | $11M | $9M | $14M | $11M | $12M | $4M | $2M | $0 | $0 | · | · | |
| R&D Expense | $916M | $902M | $900M | · | $638M | $531M | $462M | $412M | $372M | $340M | $320M | $239M | |
| SG&A Expense | $394M | $267M | $233M | $150M | $186M | $354M | $287M | $245M | $108M | $49M | $37M | $20M | |
| Operating Expenses | $1.33B | $1.18B | $1.14B | $998M | $841M | $901M | $757M | $661M | $483M | $393M | $359M | $262M | |
| Operating Income | $-382M | $-475M | $-354M | $-410M | $-30M | $-172M | $366M | $-61M | $31M | $-20M | $-76M | $-48M | |
| Interest Expense | $17M | $17M | $13M | $8M | $9M | $10M | $12M | $45M | $45M | $39M | $37M | $22M | |
| Other Non-op | $-15M | $1M | $14M | $-7M | $-10M | $-62.0K | $-686.0K | $-182.0K | $-4M | $0 | · | · | |
| Pretax Income | $-380M | $-460M | $-334M | $-258M | $-29M | $-135M | $339M | $-76M | $-17M | $-57M | $-88M | $-54M | |
| Income Tax | $2M | $-6M | $32M | $12M | $-551.0K | $345M | $52M | $-291M | $-6M | $3M | $372.0K | $-15M | |
| Net Income | $-381M | $-454M | $-366M | $-270M | $-29M | $-444M | $278M | $274M | $346.0K | $-60M | $-88M | $-39M | |
| EPS (Basic) | $-2.38 | $-3.04 | $-2.56 | $-1.90 | $-0.20 | $-3.18 | $2.00 | $2.09 | $0.15 | $-0.50 | $-0.74 | · | |
| EPS (Diluted) | $-2.38 | $-3.04 | $-2.56 | $-1.90 | $-0.20 | $-3.18 | $1.90 | $2.07 | $0.15 | $-0.50 | $-0.74 | · | |
| Shares (Basic) | 160,010,000 | 149,514,000 | 143,190,000 | 141,848,000 | 141,021,000 | 139,612,000 | 139,998,000 | 132,320,000 | 124,016,000 | 120,933,000 | 119,719,000 | · | |
| Shares (Diluted) | 160,010,000 | 149,514,000 | 143,190,000 | 141,848,000 | 141,021,000 | 139,612,000 | 153,164,000 | 134,056,000 | 126,098,000 | 120,933,000 | 119,719,000 | · | |
| EBITDA | $-382M | $-475M | $-354M | $-410M | $-30M | $-172M | $366M | $-61M | $25M | $-46M | $-76M | $-48M |
Balance general 24
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $372M | $242M | $399M | $276M | $869M | $398M | $683M | $279M | $130M | $85M | $129M | $143M | |
| Short-term Investments | $2.31B | $2.06B | $1.93B | $1.71B | $1.25B | · | · | · | · | · | · | · | |
| Inventory | $10M | $13M | $7M | $22M | $25M | $22M | $18M | $9M | $10M | · | · | · | |
| Other Current Assets | $237M | $218M | $205M | $168M | $143M | $140M | $140M | $102M | $73M | $17M | $15M | $16M | |
| Current Assets | $2.99B | $2.62B | $2.64B | $2.20B | $2.35B | $2.13B | $2.72B | $2.21B | $1.17B | $798M | $837M | $837M | |
| PP&E (Net) | $123M | $94M | $71M | $74M | $178M | $181M | $154M | $132M | $122M | $93M | $90M | $89M | |
| Accum. Depreciation | $109M | $106M | $97M | $88M | $103M | $87M | $74M | $61M | $88M | $80M | $73M | $66M | |
| Intangibles | · | · | · | · | $29M | $28M | $26M | $24M | $22M | $20M | · | · | |
| Other Non-current Assets | $172M | $127M | $105M | $75M | $71M | $50M | $28M | $13M | $10M | $1M | · | · | |
| Total Assets | $3.52B | $3.00B | $2.99B | $2.53B | $2.61B | $2.39B | $3.23B | $2.67B | $1.32B | $912M | $948M | $956M | |
| Accounts Payable | $28M | $43M | $26M | $18M | $12M | $17M | $16M | $29M | $25M | $21M | $28M | $18M | |
| Accrued Liabilities | $106M | $108M | $148M | $140M | $89M | $90M | $67M | $48M | $67M | $36M | $28M | $30M | |
| Current Liabilities | $782M | $309M | $448M | $312M | $241M | $599M | $273M | $280M | $244M | $134M | $149M | $115M | |
| Capital Leases | $262M | $162M | $171M | $179M | $19M | · | · | · | · | · | · | · | |
| Other Non-current Liabilities | $28M | $52M | $42M | $16M | $7M | · | · | · | · | · | · | · | |
| Total Liabilities | $3.03B | $2.42B | $2.60B | $1.96B | $1.84B | $1.65B | $1.55B | $1.48B | $957M | $813M | $747M | $698M | |
| Long-term Debt | $1.81B | $1.25B | $1.31B | $1.19B | · | · | · | · | · | · | · | · | |
| Total Debt | $1.76B | $1.20B | $1.24B | $1.18B | · | · | · | · | · | · | · | · | |
| Common Stock | $163.0K | $158.0K | $144.0K | $142.0K | $141.0K | $140.0K | $140.0K | $138.0K | $125.0K | $122.0K | $120.0K | $118.0K | |
| Retained Earnings | $-2.63B | $-2.25B | $-1.80B | $-1.43B | $-1.16B | $-1.13B | $-708M | $-967M | $-1.24B | $-1.18B | $-1.09B | $-1.01B | |
| AOCI | $-25M | $-31M | $-33M | $-57M | $-33M | $-21M | $-25M | $-32M | $-32M | $-30M | $-14M | $40M | |
| Stockholders' Equity | $489M | $588M | $387M | $573M | $772M | $743M | $1.47B | $1.05B | $281M | $100M | $201M | $258M | |
| Liabilities + Equity | $3.52B | $3.00B | $2.99B | $2.53B | $2.61B | $2.39B | $3.23B | $2.67B | $1.32B | $912M | $948M | $956M | |
| Shares Outstanding | 163,304,875 | 157,908,815 | 144,340,526 | 142,057,736 | 141,210,015 | 140,365,594 | 140,339,615 | 137,928,828 | 124,976,373 | 121,636,273 | 120,351,480 | 118,442,726 |
Flujo de Efectivo 14
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $134M | $130M | $106M | $100M | $121M | $230M | $147M | $131M | $86M | $72M | $59M | $31M | |
| Deferred Tax | $0 | $0 | $0 | $0 | $0 | $342M | $904.0K | $-291M | $0 | $0 | $0 | $-11M | |
| Amort. of Intangibles | $2M | $2M | $3M | $2M | $2M | $2M | $2M | $2M | $2M | $2M | · | · | |
| Operating Cash Flow | $-269M | $-501M | $-308M | $-274M | $31M | $36M | $346M | $603M | $174M | $-112M | $21M | $6M | |
| CapEx | $51M | $45M | $24M | $16M | $12M | $35M | $31M | $14M | $35M | $7M | $8M | $8M | |
| Investing Cash Flow | $-278M | $-134M | $-214M | $-263M | $195M | $274M | $-41M | $-930M | $-358M | $57M | $-60M | · | |
| Stock Issued | $0 | $489M | $0 | $0 | · | $0 | $0 | $448M | $72M | $0 | $0 | $0 | |
| Stock Repurchased | · | · | · | $0 | $0 | $91M | $34M | $0 | $0 | · | · | · | |
| Net Stock Activity | $0 | $489M | · | $0 | $0 | $-91M | $-34M | · | $72M | · | $0 | $0 | |
| Financing Cash Flow | $676M | $478M | $644M | $-55M | $246M | $-597M | $100M | $476M | $229M | $11M | $25M | · | |
| Net Change in Cash | $130M | $-157M | $123M | $-593M | $472M | $-286M | $404M | $149M | $45M | $-44M | $-14M | · | |
| Taxes Paid | $-639.0K | $-6M | $48M | $5M | · | $26M | $9M | $0 | $0 | · | · | · | |
| Free Cash Flow | $-320M | $-546M | $-331M | $-290M | $19M | $772.0K | $315M | $589M | $139M | $-119M | $13M | $-1M | |
| Levered FCF | $-337M | $-563M | $-345M | $-299M | $10M | $-128M | $272M | $716M | $106M | $-159M | $-23M | $-17M |
Rentabilidad 7
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | · | · | · | · | · | · | · | · | 4.8% | -13.4% | -26.7% | -22.3% | |
| Net Margin | · | · | · | · | · | · | · | · | -1.2% | -25.0% | -31.1% | -18.2% | |
| Pretax Margin | · | · | · | · | · | · | · | · | -4.6% | -24.1% | -31.0% | -25.4% | |
| EBITDA Margin | · | · | · | · | · | · | · | · | 4.8% | -13.4% | -26.7% | -22.3% | |
| ROA | -11.7% | -15.2% | -13.3% | -10.5% | -1.1% | -16.1% | 10.0% | 13.7% | -0.53% | -9.3% | -9.2% | -4.3% | |
| ROE | -68.1% | -71.9% | -104.3% | -40.1% | -3.8% | -39.0% | 23.4% | 41.2% | -2.8% | -57.6% | -38.5% | -12.3% | |
| ROIC | -17.1% | -26.0% | -23.8% | -24.5% | -3.8% | -58.4% | 21.8% | 16.5% | 5.5% | -48.1% | -37.9% | -13.3% |
Liquidez y Solvencia 5
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 3.8 | 8.5 | 5.9 | 7.1 | 9.7 | 3.7 | 10.0 | 7.9 | 5.2 | 6.0 | 5.6 | 7.3 | |
| Quick Ratio | 3.4 | 7.4 | 5.2 | 6.4 | 3.6 | 0.7 | 2.5 | 1.0 | 0.6 | 0.6 | 0.9 | 1.2 | |
| Debt / Equity | 3.6 | 2.0 | 3.2 | 2.1 | · | · | · | · | · | · | · | · | |
| LT Debt / Equity | 2.7 | 2.0 | 3.2 | 2.1 | · | · | · | · | · | · | · | · | |
| Interest Coverage | -22.1 | -28.0 | -27.9 | -50.5 | -3.2 | -3.8 | 7.5 | -1.4 | 0.5 | -1.2 | -2.1 | -2.1 |
Eficiencia 2
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | · | · | · | · | · | · | · | · | 0.5 | 0.4 | 0.3 | 0.2 | |
| Inventory Turnover | 1.4 | 1.1 | 0.4 | 0.6 | 0.5 | 0.6 | 0.3 | 0.2 | · | · | · | · |
Valoración (TTM) 14
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $944M | $705M | $788M | $587M | $810M | $729M | $1.12B | $600M | $508M | $347M | $284M | $214M | |
| Net Income TTM | $-381M | $-454M | $-366M | $-270M | $-29M | $-444M | $278M | $274M | $346.0K | $-60M | $-88M | $-39M | |
| Market Cap | $12.92B | $5.52B | $7.30B | $5.37B | $4.30B | $7.94B | $8.48B | $7.46B | $6.29B | $5.82B | $7.45B | $7.31B | |
| Enterprise Value | $12.00B | $4.43B | $6.21B | $4.55B | · | · | · | · | · | · | · | · | |
| P/E | -33.2 | -11.5 | -19.8 | -19.9 | -152.2 | -17.8 | 31.8 | 26.1 | 335.3 | -95.7 | -83.7 | -176.4 | |
| P/S | 13.7 | 7.8 | 9.3 | 9.1 | 5.3 | 10.9 | 7.6 | 12.4 | 12.4 | 16.8 | 26.3 | 34.1 | |
| P/B | 26.4 | 9.2 | 18.9 | 9.4 | 5.6 | 9.4 | 5.8 | 7.1 | 19.0 | 58.4 | 37.1 | 28.4 | |
| P / Tangible Book | 26.4 | 9.4 | 18.9 | 9.4 | 5.8 | 11.1 | · | · | · | · | · | · | |
| P / Cash Flow | -48.1 | -11.0 | -23.7 | -19.6 | 139.5 | 221.1 | 24.5 | 12.4 | 36.1 | -51.9 | 352.8 | 1163.5 | |
| P / FCF | -40.4 | -10.1 | -22.0 | -18.5 | 228.0 | 10280.1 | 26.9 | 12.7 | 45.1 | -48.8 | 554.9 | -5930.8 | |
| EV / EBITDA | -31.4 | -9.3 | -17.6 | -11.1 | · | · | · | · | · | · | · | · | |
| EV / FCF | -37.5 | -8.1 | -18.7 | -15.7 | · | · | · | · | · | · | · | · | |
| EV / Revenue | 12.7 | 6.3 | 7.9 | 7.8 | · | · | · | · | · | · | · | · | |
| Earnings Yield | -3.0% | -8.7% | -5.1% | -5.0% | -0.66% | -5.6% | 3.1% | 3.8% | 0.30% | -1.1% | -1.2% | -0.57% |
Estado de resultados 15
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $268M | $246M | $203M | $157M | $452M | $132M | $227M | $134M | $225M | $119M | $325M | $144M | $188M | $131M | $152M | $160M | |
| Cost of Revenue | $3M | $3M | $8M | $2M | $4M | $1M | $4M | $1M | $4M | $2M | $3M | $2M | $3M | $1M | $4M | $2M | |
| SG&A Expense | $150M | $150M | $130M | $97M | $91M | $76M | $88M | $62M | $65M | $53M | $71M | $70M | $46M | $46M | $48M | $34M | |
| Operating Expenses | $370M | $364M | $418M | $317M | $312M | $278M | $337M | $282M | $291M | $269M | $331M | $287M | $279M | $245M | $360M | $219M | |
| Operating Income | $-102M | $-117M | $-214M | $-160M | $140M | $-147M | $-111M | $-149M | $-66M | $-150M | $-6M | $-143M | $-90M | $-114M | $-208M | $-59M | |
| Interest Expense | $5M | $5M | $5M | $4M | $4M | $4M | $4M | $4M | $4M | $4M | $5M | $4M | $2M | $2M | $2M | $2M | |
| Other Non-op | $987.0K | $-456.0K | $-16M | $363.0K | $102.0K | $465.0K | $302.0K | $142.0K | $610.0K | $277.0K | $235.0K | $2M | $11M | $230.0K | $123.0K | $5M | |
| Pretax Income | $-113M | $-92M | $-228M | $-128M | $124M | $-147M | $-107M | $-144M | $-66M | $-143M | $-3M | $-141M | $-77M | $-113M | $-44M | $-47M | |
| Income Tax | $1M | $218.0K | $1M | $213.0K | $-20.0K | $116.0K | $-3M | $-4M | $64.0K | $75.0K | $6M | $7M | $8M | $11M | $8M | $283.0K | |
| Net Income | $-115M | $-93M | $-229M | $-129M | $124M | $-147M | $-104M | $-140M | $-66M | $-143M | $-9M | $-147M | $-85M | $-124M | $-52M | $-47M | |
| EPS (Basic) | $-0.69 | $-0.56 | $-1.41 | $-0.80 | $0.78 | $-0.93 | $-0.66 | $-0.95 | $-0.45 | $-0.98 | $-0.06 | $-1.03 | $-0.60 | $-0.87 | $-0.37 | $-0.33 | |
| EPS (Diluted) | $-0.69 | $-0.56 | $-1.41 | $-0.80 | $0.70 | $-0.93 | $-0.66 | $-0.95 | $-0.45 | $-0.98 | $-0.06 | $-1.03 | $-0.60 | $-0.87 | $-0.37 | $-0.33 | |
| Shares (Basic) | 165,419,000 | 164,874,000 | -317,627,000 | 159,765,000 | 159,137,000 | 158,735,000 | -290,575,000 | 148,593,000 | 145,958,000 | 145,538,000 | -285,960,000 | 143,317,000 | 143,098,000 | 142,735,000 | -283,495,000 | 141,950,000 | |
| Shares (Diluted) | 165,419,000 | 164,874,000 | -340,821,000 | 159,765,000 | 182,331,000 | 158,735,000 | -290,575,000 | 148,593,000 | 145,958,000 | 145,538,000 | -285,960,000 | 143,317,000 | 143,098,000 | 142,735,000 | -283,495,000 | 141,950,000 | |
| EBITDA | $-102M | $-117M | · | $-160M | $140M | $-147M | · | $-149M | $-66M | $-150M | · | $-143M | $-90M | $-114M | · | $-59M |
Balance general 23
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $350M | $173M | $372M | $338M | $297M | $264M | $242M | $335M | $294M | $349M | · | $352M | $425M | $309M | · | $315M | |
| Short-term Investments | $1.70B | $1.75B | $2.31B | $1.90B | $1.99B | $1.88B | $2.06B | $2.15B | $1.78B | $1.86B | · | $1.88B | $1.96B | $2.04B | · | $1.67B | |
| Inventory | $51M | $6M | $10M | $10M | $8M | $12M | $13M | $28M | $29M | $30M | · | $26M | $26M | $22M | · | $21M | |
| Other Current Assets | $327M | $306M | $237M | $244M | $226M | $223M | $218M | $184M | $195M | $174M | · | $181M | $178M | $160M | · | $143M | |
| Current Assets | $2.49B | $2.94B | $2.99B | $2.52B | $2.58B | $2.42B | $2.62B | $2.71B | $2.33B | $2.42B | · | $2.58B | $2.62B | $2.54B | · | $2.15B | |
| PP&E (Net) | $155M | $142M | $123M | $106M | $112M | $103M | $94M | $83M | $76M | $73M | · | $71M | $92M | $85M | · | $181M | |
| Accum. Depreciation | · | · | $109M | · | · | · | $106M | · | · | · | · | · | · | · | · | · | |
| Intangibles | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $30M | |
| Other Non-current Assets | $117M | $136M | $172M | $166M | $132M | $132M | $127M | $120M | $119M | $106M | · | $104M | $86M | $78M | · | $59M | |
| Total Assets | $2.99B | $3.45B | $3.52B | $3.03B | $2.99B | $2.81B | $3.00B | $3.08B | $2.69B | $2.76B | · | $2.93B | $2.97B | $2.89B | · | $2.42B | |
| Accounts Payable | $48M | $26M | $28M | $14M | $23M | $17M | $43M | $9M | $9M | $13M | · | $6M | $24M | $10M | · | $21M | |
| Accrued Liabilities | $116M | $127M | $106M | $99M | $99M | $103M | $108M | $124M | $114M | $106M | · | $119M | $105M | $113M | · | $128M | |
| Current Liabilities | $316M | $717M | $782M | $903M | $897M | $250M | $309M | $305M | $306M | $328M | · | $404M | $288M | $259M | · | $283M | |
| Capital Leases | $262M | $259M | $262M | $263M | $164M | $159M | $162M | $168M | $166M | $169M | · | $173M | $175M | $177M | · | · | |
| Other Non-current Liabilities | $28M | $28M | · | $29M | $59M | $56M | · | $42M | $42M | $42M | · | $49M | $16M | $7M | · | · | |
| Total Liabilities | $2.55B | $2.96B | $3.03B | $2.42B | $2.35B | $2.34B | $2.42B | $2.42B | $2.43B | $2.47B | · | $2.62B | $2.54B | $2.40B | · | $1.83B | |
| Long-term Debt | · | · | $1.81B | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Common Stock | $166.0K | $166.0K | $163.0K | $161.0K | $159.0K | $159.0K | $158.0K | $158.0K | $146.0K | $146.0K | · | $143.0K | $143.0K | $143.0K | · | $142.0K | |
| Retained Earnings | $-2.84B | $-2.72B | $-2.63B | $-2.40B | $-2.27B | $-2.40B | $-2.25B | $-2.15B | $-2.00B | $-1.94B | · | $-1.79B | $-1.64B | $-1.55B | · | $-1.38B | |
| AOCI | $-34M | $-31M | $-25M | $-26M | $-28M | $-29M | $-31M | $-24M | $-35M | $-35M | · | $-46M | $-51M | $-49M | · | $-63M | |
| Stockholders' Equity | $440M | $491M | $489M | $618M | $632M | $476M | $588M | $662M | $264M | $297M | $387M | $315M | $428M | $487M | $573M | $594M | |
| Liabilities + Equity | $2.99B | $3.45B | $3.52B | $3.03B | $2.99B | $2.81B | $3.00B | $3.08B | $2.69B | $2.76B | · | $2.93B | $2.97B | $2.89B | · | $2.42B | |
| Shares Outstanding | 165,636,792 | 165,902,064 | 163,304,875 | 161,137,930 | 159,196,782 | 159,041,259 | 157,908,815 | 157,813,136 | 146,025,246 | 145,844,719 | · | 143,393,493 | 143,167,414 | 143,022,539 | · | 142,017,411 |
Flujo de Efectivo 11
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $46M | $43M | $43M | $31M | $30M | $30M | $36M | $32M | $31M | $31M | $26M | $26M | $27M | $27M | $26M | $24M | |
| Amort. of Intangibles | $700.0K | $661.0K | $638.0K | $621.0K | $598.0K | $582.0K | $459.0K | $617.0K | $621.0K | $639.0K | $655.0K | $660.0K | $637.0K | $607.0K | $610.0K | $608.0K | |
| Operating Cash Flow | $566M | $-793M | $-138M | $-131M | $151M | $-151M | $-116M | $-115M | $-120M | $-150M | $33M | $-109M | $-97M | $-134M | $-200M | $-24M | |
| CapEx | $16M | $22M | $21M | $5M | $12M | $13M | $25M | $9M | $6M | $4M | $-819.0K | $2M | $12M | $10M | $4M | $6M | |
| Investing Cash Flow | $23M | $537M | $-420M | $91M | $-120M | $170M | $68M | $-341M | $62M | $76M | $-27M | $69M | $70M | $-326M | $212M | $-184M | |
| Stock Issued | · | · | $0 | · | · | · | $27.0K | · | · | · | $0 | · | · | · | · | · | |
| Financing Cash Flow | $-412M | $57M | $591M | $81M | $1M | $2M | $-44M | $496M | $3M | $24M | $41M | $-32M | $144M | $492M | $-51M | $2M | |
| Net Change in Cash | $177M | $-199M | $34M | $41M | $33M | $22M | $-93M | $41M | $-55M | $-50M | $47M | $-73M | $116M | $33M | $-39M | $-207M | |
| Taxes Paid | $1M | $-8.0K | $22.0K | $-278.0K | $17.0K | $-400.0K | $-8M | $80.0K | $2M | $13.0K | · | · | · | · | · | · | |
| Free Cash Flow | · | $-815M | · | · | · | $-163M | · | · | · | $-154M | · | · | · | $-144M | · | · | |
| Levered FCF | · | $-820M | · | · | · | $-167M | · | · | · | $-159M | · | · | · | $-146M | · | · |
Rentabilidad 7
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -38.2% | -47.7% | · | -102.2% | 30.9% | -111.6% | · | -111.1% | -29.3% | -125.1% | · | -99.4% | -47.9% | -87.5% | · | -37.0% | |
| Net Margin | -42.8% | -37.6% | · | -82.1% | 27.3% | -111.6% | · | -105.0% | -29.4% | -119.5% | · | -102.2% | -45.3% | -95.2% | · | -29.4% | |
| Pretax Margin | -42.3% | -37.5% | · | -81.9% | 27.3% | -111.6% | · | -107.7% | -29.4% | -119.4% | · | -97.6% | -41.1% | -86.5% | · | -29.2% | |
| EBITDA Margin | -38.2% | -47.7% | · | -102.2% | 30.9% | -111.6% | · | -111.1% | -29.3% | -125.1% | · | -99.4% | -47.9% | -87.5% | · | -37.0% | |
| ROA | -3.8% | -2.9% | · | -4.2% | 4.3% | -5.3% | · | -4.7% | -2.3% | -5.1% | · | -5.5% | -3.1% | -4.6% | · | -1.9% | |
| ROE | -21.4% | -19.1% | · | -20.1% | 27.6% | -38.0% | · | -28.7% | -19.1% | -36.5% | · | -32.4% | -16.2% | -20.8% | · | -8.3% | |
| ROIC | -23.5% | -23.9% | · | -26.0% | 22.1% | -30.9% | · | -21.9% | -25.1% | -50.4% | · | -47.5% | -23.2% | -25.8% | · | -10.0% |
Liquidez y Solvencia 3
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 7.9 | 4.1 | · | 2.8 | 2.9 | 9.7 | · | 8.9 | 7.6 | 7.4 | · | 6.4 | 9.1 | 9.8 | · | 7.6 | |
| Quick Ratio | 6.5 | 2.7 | · | 2.5 | 2.6 | 8.6 | · | 8.2 | 6.8 | 6.7 | · | 5.5 | 8.3 | 9.1 | · | 7.0 | |
| Interest Coverage | -22.2 | -22.8 | · | -38.0 | 34.0 | -35.7 | · | -35.7 | -14.7 | -36.0 | · | -34.1 | -39.4 | -71.0 | · | -27.7 |
Eficiencia 2
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.1 | 0.1 | · | 0.1 | 0.2 | 0.0 | · | 0.0 | 0.1 | 0.0 | · | 0.1 | 0.1 | 0.0 | · | 0.1 | |
| Inventory Turnover | 0.1 | 0.3 | · | 0.1 | 0.2 | 0.1 | · | 0.0 | 0.2 | 0.1 | · | 0.1 | 0.1 | 0.1 | · | 0.1 |
Valoración (TTM) 10
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $874M | $1.06B | · | $967M | $944M | $717M | · | $803M | $813M | $777M | · | $615M | $631M | $576M | · | $875M | |
| Net Income TTM | $-565M | $-327M | · | $-256M | $-268M | $-458M | · | $-359M | $-366M | $-385M | · | $-409M | $-309M | $-329M | · | $7M | |
| Market Cap | $13.13B | $12.46B | · | $10.54B | $6.29B | $4.80B | · | $6.32B | $6.96B | $6.32B | · | $6.50B | $5.87B | $5.11B | · | $6.28B | |
| P/E | -22.9 | -36.3 | · | -38.7 | -21.5 | -10.1 | · | -16.4 | -18.9 | -16.2 | · | -15.8 | -18.9 | -15.5 | · | -368.6 | |
| P/S | 15.0 | 11.8 | · | 10.9 | 6.7 | 6.7 | · | 7.9 | 8.6 | 8.1 | · | 10.6 | 9.3 | 8.9 | · | 7.2 | |
| P/B | 29.9 | 25.4 | · | 17.1 | 10.0 | 10.1 | · | 9.5 | 26.4 | 21.3 | · | 20.6 | 13.7 | 10.5 | · | 10.6 | |
| P / Tangible Book | 29.9 | 25.4 | · | 17.1 | 10.0 | 10.1 | · | 9.5 | 26.4 | 21.3 | · | 20.6 | 13.7 | 10.5 | · | 11.1 | |
| P / Cash Flow | · | -15.7 | · | · | · | -31.8 | · | · | · | -42.2 | · | · | · | -38.1 | · | · | |
| P / FCF | · | -15.3 | · | · | · | -29.4 | · | · | · | -40.9 | · | · | · | -35.4 | · | · | |
| Earnings Yield | -4.4% | -2.8% | · | -2.6% | -4.7% | -9.9% | · | -6.1% | -5.3% | -6.2% | · | -6.3% | -5.3% | -6.5% | · | -0.27% |
Estados Financieros Estado de resultados, balance general, flujo de caja — anual, últimos 5 años
Estado de resultados
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Beneficio neto | $-381M | $-454M | $-366M | $-270M | $-29M |
| EPS Diluido | $-2.38 | $-3.04 | $-2.56 | $-1.90 | $-0.20 |
Balance general
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Deuda / Patrimonio | 3.6 | 2.0 | 3.2 | 2.1 | — |
| Ratio corriente | 3.8 | 8.5 | 5.9 | 7.1 | 9.7 |
| Ratio Rápido | 3.4 | 7.4 | 5.2 | 6.4 | 3.6 |
Flujo de Efectivo
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Flujo de caja libre | $-320M | $-546M | $-331M | $-290M | $19M |
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Propietarios institucionales (13F) 575 declarantes · $10.8B total · A fecha de 30 de junio de 2026
Instituciones que informan tener esta acción en su Formulario 13F trimestral de la SEC. Solo posiciones largas; un solo presentador puede aparecer dos veces para tramos de opciones separados. Las patas de put/call de compensación grandes suelen reflejar la creación de mercado o el inventario cubierto, no la convicción direccional.
Actividad institucional — Q2 2026 vs trimestre anterior
| Nuevas posiciones | Posiciones cerradas | Aumentado | Disminuido | Cambio neto de acciones |
|---|---|---|---|---|
| 80 (-4 vs trimestre anterior) | 40 (-25 vs trimestre anterior) | 199 (+17 vs trimestre anterior) | 156 (+3 vs trimestre anterior) | +28.2M |
Comparado con Q1 2026. Las presentaciones del Formulario 13F de la SEC vencen dentro de los 45 días posteriores al final del trimestre, más un pequeño margen para los presentadores tardíos; los trimestres que aún se encuentran dentro de esa ventana se omiten en favor del par más reciente completamente reportado.
| Institución | Valor | Acciones | % de 13F rastreadas | Tipo |
|---|---|---|---|---|
| Capital World Investors | $1 718 152 930 | 21 669 226 | 15,90% | Acciones |
| FMR LLC | $1 062 239 646 | 13 396 893 | 9,83% | Acciones |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $623 182 054 | 7 859 529 | 5,77% | Acciones |
| VANGUARD CAPITAL MANAGEMENT LLC | $571 799 597 | 7 211 497 | 5,29% | Acciones |
| WELLINGTON MANAGEMENT GROUP LLP | $558 240 214 | 7 040 487 | 5,17% | Acciones |
| TWO SIGMA INVESTMENTS, LP | $495 748 197 | 6 252 342 | 4,59% | Acciones |
| STATE STREET CORP | $343 710 098 | 4 334 848 | 3,18% | Acciones |
| GEODE CAPITAL MANAGEMENT, LLC | $260 920 005 | 3 157 327 | 2,41% | Acciones |
| TWO SIGMA ADVISERS, LP | $241 452 501 | 3 052 111 | 2,23% | Acciones |
| Artisan Partners Limited Partnership | $209 327 536 | 2 640 024 | 1,94% | Acciones |
| Tweedy, Browne Co LLC | $180 805 859 | 2 280 311 | 1,67% | Acciones |
| Deep Track Capital, LP | $174 438 000 | 2 200 000 | 1,61% | Acciones |
| BAKER BROS. ADVISORS LP | $162 364 274 | 2 047 727 | 1,50% | Acciones |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $156 967 955 | 1 979 669 | 1,45% | Acciones |
| AMERICAN CENTURY COMPANIES INC | $154 383 816 | 1 947 076 | 1,43% | Acciones |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $127 260 529 | 1 605 001 | 1,18% | Acciones |
| Pictet Asset Management Holding SA | $126 981 913 | 1 596 998 | 1,18% | Acciones |
| BARCLAYS PLC | $125 150 305 | 1 578 387 | 1,16% | Acciones |
| GOLDMAN SACHS GROUP INC | $117 215 755 | 1 478 317 | 1,08% | Acciones |
| Polar Capital Holdings Plc | $115 289 325 | 1 454 021 | 1,07% | Acciones |
| Alyeska Investment Group, L.P. | $112 426 560 | 1 417 916 | 1,04% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $103 108 716 | 1 300 400 | 0,95% | Opción de compra |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $103 108 000 | 1 300 392 | 0,95% | Acciones |
| VANGUARD FIDUCIARY TRUST CO | $84 114 400 | 1 060 845 | 0,78% | Acciones |
| GROUPAMA ASSET MANAGMENT | $75 195 315 | 937 083 | 0,70% | Acciones |
| Capital International Investors | $65 316 248 | 823 764 | 0,60% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $65 184 309 | 822 100 | 0,60% | Opción de venta |
| Davern Capital Partners, LP | $63 329 637 | 798 709 | 0,59% | Acciones |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | $62 422 083 | 787 263 | 0,58% | Acciones |
| Connor, Clark & Lunn Investment Management Ltd. | $54 253 072 | 684 236 | 0,50% | Acciones |
| Eversept Partners, LP | $52 702 794 | 664 684 | 0,49% | Acciones |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $51 970 948 | 655 454 | 0,48% | Acciones |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $51 370 722 | 647 884 | 0,48% | Acciones |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $50 113 500 | 632 028 | 0,46% | Acciones |
| Caption Management, LLC | $49 952 700 | 630 000 | 0,46% | Opción de compra |
| NEUBERGER BERMAN GROUP LLC | $46 951 653 | 592 151 | 0,43% | Acciones |
| EVENTIDE ASSET MANAGEMENT, LLC | $45 591 750 | 575 000 | 0,42% | Acciones |
| PERCEPTIVE ADVISORS LLC | $44 878 140 | 566 000 | 0,42% | Acciones |
| RENAISSANCE TECHNOLOGIES LLC | $44 355 936 | 559 414 | 0,41% | Acciones |
| JANE STREET GROUP, LLC | $44 045 595 | 555 500 | 0,41% | Opción de compra |
| JANE STREET GROUP, LLC | $43 070 328 | 543 200 | 0,40% | Opción de venta |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $41 414 514 | 522 317 | 0,38% | Acciones |
| BOONE CAPITAL MANAGEMENT LLC | $41 228 976 | 519 977 | 0,38% | Acciones |
| NEW YORK STATE COMMON RETIREMENT FUND | $39 648 965 | 500 050 | 0,37% | Acciones |
| BNP PARIBAS FINANCIAL MARKETS | $36 049 119 | 454 649 | 0,33% | Acciones |
| Candriam S.C.A. | $35 251 607 | 445 019 | 0,33% | Acciones |
| FIRST TRUST ADVISORS LP | $33 872 360 | 427 197 | 0,31% | Acciones |
| PINNACLE ASSOCIATES LTD | $33 282 136 | 419 752 | 0,31% | Acciones |
| BANK OF AMERICA CORP /DE/ | $32 643 138 | 411 693 | 0,30% | Acciones |
| NOMURA HOLDINGS INC | $31 889 804 | 402 192 | 0,30% | Acciones |
| Ikarian Capital, LLC | $31 716 000 | 400 000 | 0,29% | Opción de compra |
| CITADEL ADVISORS LLC | $30 645 585 | 386 500 | 0,28% | Opción de venta |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $28 771 090 | 362 859 | 0,27% | Acciones |
| BlackRock, Inc. | $28 184 582 | 355 462 | 0,26% | Acciones |
| Caption Management, LLC | $27 426 411 | 345 900 | 0,25% | Opción de venta |
| TD Asset Management Inc | $27 002 051 | 340 548 | 0,25% | Acciones |
| Freestone Grove Partners LP | $26 955 983 | 339 967 | 0,25% | Acciones |
| AXA Investment Managers S.A. | $26 590 024 | 406 451 | 0,25% | Acciones |
| Qube Research & Technologies Ltd | $26 479 054 | 333 952 | 0,25% | Acciones |
| Capital Research Global Investors | $26 319 205 | 331 936 | 0,24% | Acciones |
| CAPITAL FUND MANAGEMENT S.A. | $26 130 336 | 329 554 | 0,24% | Acciones |
| ALLIANCEBERNSTEIN L.P. | $25 564 391 | 340 450 | 0,24% | Acciones |
| Carmignac Gestion | $25 452 090 | 321 000 | 0,24% | Acciones |
| Privium Fund Management B.V. | $25 366 774 | 319 924 | 0,23% | Acciones |
| Swiss National Bank | $24 976 350 | 315 000 | 0,23% | Acciones |
| ARK Investment Management LLC | $23 848 064 | 300 770 | 0,22% | Acciones |
| Integral Health Asset Management, LLC | $23 787 000 | 300 000 | 0,22% | Opción de compra |
| Ikarian Capital, LLC | $23 787 000 | 300 000 | 0,22% | Opción de venta |
| MILLENNIUM MANAGEMENT LLC | $22 904 661 | 288 872 | 0,21% | Acciones |
| DAVENPORT & Co LLC | $22 515 188 | 283 960 | 0,21% | Acciones |
| Aberdeen Group plc | $21 995 046 | 277 400 | 0,20% | Acciones |
| California Public Employees Retirement System | $21 475 141 | 270 843 | 0,20% | Acciones |
| TimesSquare Capital Management, LLC | $20 700 361 | 275 674 | 0,19% | Acciones |
| MILLENNIUM MANAGEMENT LLC | $20 417 175 | 257 500 | 0,19% | Opción de compra |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | $19 918 837 | 251 215 | 0,18% | Acciones |
| CITADEL ADVISORS LLC | $18 709 189 | 235 959 | 0,17% | Acciones |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $18 514 136 | 233 499 | 0,17% | Acciones |
| CITADEL ADVISORS LLC | $18 434 925 | 232 500 | 0,17% | Opción de compra |
| Orion Investment Co | $17 470 362 | 220 335 | 0,16% | Acciones |
| Life Cycle Investment Partners Ltd | $17 435 554 | 219 896 | 0,16% | Acciones |
| ALGERT GLOBAL LLC | $16 401 374 | 206 853 | 0,15% | Acciones |
| Corient Private Wealth LP | $15 603 561 | 196 791 | 0,14% | Acciones |
| Eagle Health Investments LP | $15 428 010 | 194 577 | 0,14% | Acciones |
| SECTOR GAMMA AS | $15 022 918 | 189 468 | 0,14% | Acciones |
| Polymer Capital Management (HK) LTD | $14 105 453 | 177 897 | 0,13% | Acciones |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $13 252 259 | 176 485 | 0,12% | Acciones |
| ADAR1 Capital Management, LLC | $13 184 817 | 166 286 | 0,12% | Acciones |
| RHUMBLINE ADVISERS | $13 075 750 | 164 911 | 0,12% | Acciones |
| Sicart Associates LLC | $12 741 427 | 160 694 | 0,12% | Acciones |
| VANGUARD ASSET MANAGEMENT, Ltd | $12 296 928 | 155 088 | 0,11% | Acciones |
| CSS LLC/IL | $12 074 995 | 152 289 | 0,11% | Acciones |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | $11 996 656 | 151 301 | 0,11% | Acciones |
| CITIGROUP INC | $11 996 577 | 151 300 | 0,11% | Opción de compra |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $11 893 500 | 150 000 | 0,11% | Acciones |
| Focus Partners Wealth | $11 728 366 | 147 917 | 0,11% | Acciones |
| Hudson Bay Capital Management LP | $11 497 050 | 145 000 | 0,11% | Acciones |
| Artia Global Partners LP | $11 447 573 | 144 376 | 0,11% | Acciones |
| Sonora Investment Management Group, LLC | $11 108 840 | 169 808 | 0,10% | Acciones |
| Fisher Asset Management, LLC | $10 877 317 | 137 184 | 0,10% | Acciones |
| Atle Fund Management AB | $10 873 116 | 137 131 | 0,10% | Acciones |
Informantes de la empresa 48 insiders · 30 directivos · 19 consejeros
| Insider | Rol | Última actividad | Acciones en propiedad | Compras 12m | Ventas 12m | Neto 12m |
|---|---|---|---|---|---|---|
| Brett P Monia | Chief Executive Officer | 26 de junio de 2026 M | 245 571 | 0 | 17 | $-42 648 430 |
| HOUGEN ELIZABETH L | EVP, Finance & CFO | 16 de marzo de 2026 M | 82 660 | 0 | 6 | $-21 117 075 |
| Kleanthis G Xanthopoulos | President of Regulus | 3 de diciembre de 2007 A | — | 0 | 0 | $0 |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | 7 de julio de 2026 S | 22 096 | 0 | 4 | $-4 810 107 |
| BENNETT C FRANK | EVP, Chief Scientific Officer | 7 de julio de 2026 J | 0 | 0 | 14 | $-19 804 154 |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | 26 de junio de 2026 M | 77 114 | 0 | 6 | $-4 933 991 |
| Joseph Baroldi | EVP, Chief Business Officer | 26 de junio de 2026 M | 4 669 | 0 | 17 | $-6 405 525 |
| O'NEIL PATRICK R. | EVP CLO & General Counsel | 26 de junio de 2026 S | 61 470 | 0 | 16 | $-16 034 086 |
| Eric Swayze | EVP Research | 25 de junio de 2026 S | 21 759 | 0 | 14 | $-8 058 784 |
| Brian Birchler | EVP, Corp and Development Ops | 15 de abril de 2026 M | 67 500 | 0 | 6 | $-3 556 351 |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | 15 de abril de 2026 M | 23 713 | 0 | 4 | $-3 334 240 |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | 2 de abril de 2026 S | 16 348 | 0 | 15 | $-8 854 430 |
| Richard S Geary | EVP, Chief Development Officer | 6 de noviembre de 2025 M | 59 657 | 0 | 13 | $-13 858 595 |
| Onaiza Cadoret-Manier | EVP,Chf GL Pdt Str & Oper Ofc | 2 de febrero de 2024 S | 35 788 | 0 | 0 | $0 |
| Stanley T Crooke | Exec Chairman of the Board | 26 de enero de 2021 S | 2 021 | 0 | 0 | $0 |
| Damien Mcdevitt | Chief Business Officer | 15 de julio de 2019 M | 2 573 | 0 | 0 | $0 |
| Sarah Boyce | Chief Business Officer | 15 de enero de 2018 M | 8 931 | 0 | 0 | $0 |
| ECKER DAVID J | Vice President | 2 de septiembre de 2008 M | 0 | 0 | 0 | $0 |
| Michael J Treble | Vice President, Pres of Ibis | 11 de agosto de 2008 M | 0 | 0 | 0 | $0 |
| Jeffrey M Jonas | Executive Vice President | 2 de enero de 2008 A | — | 0 | 0 | $0 |
| Mark K Wedel | VP & Chief Medical Officer | 6 de julio de 2007 M | 6 603 | 0 | 0 | $0 |
| LEVIN ARTHUR A | Vice President | 25 de abril de 2007 M | 1 674 | 0 | 0 | $0 |
| BROWN RICHARD K | Vice President | 8 de marzo de 2006 M | 2 348 | 0 | 0 | $0 |
| MCNEIL JOHN A | Vice President | 3 de enero de 2005 A | — | 0 | 0 | $0 |
| LOWENSTAM PATRICIA | Vice President | 3 de enero de 2005 A | 603 | 0 | 0 | $0 |
| STEIN ARON | Vice President | 1 de julio de 2004 J | 1 536 | 0 | 0 | $0 |
| Hans A De Haan | VP, Drug Development | 27 de abril de 2004 S | 0 | 0 | 0 | $0 |
| LUNDSTEDT KAREN S | Vice President | 10 de marzo de 2004 M | 5 407 | 0 | 0 | $0 |
| COLE DOUGLAS L | Vice President | 9 de marzo de 2004 M | 9 616 | 0 | 0 | $0 |
| HOLMLUND JON T | Vice President | 1 de julio de 2003 J | 983 | 0 | 0 | $0 |
| Michael R Hayden | Consejero | 31 de julio de 2026 P | 24 000 | 2 | 0 | $1 058 700 |
| Peter N Reikes | Consejero | 15 de julio de 2026 A | 14 222 | 0 | 0 | $0 |
| Ludwig Hantson | Consejero | 15 de julio de 2026 A | — | 0 | 0 | $0 |
| Joan E Herman | Consejero | 15 de julio de 2026 M | 51 306 | 0 | 2 | $-3 173 720 |
| BERTHELSEN SPENCER R | Consejero | 15 de julio de 2026 M | 161 233 | 0 | 2 | $-1 193 280 |
| Allene M. Diaz | Consejero | 7 de julio de 2026 M | 3 811 | 0 | 5 | $-5 278 717 |
| Michael J. Yang | Consejero | 1 de julio de 2026 A | 7 940 | 0 | 0 | $0 |
| Joseph Loscalzo | Consejero | 1 de julio de 2026 A | 36 330 | 0 | 6 | $-8 047 872 |
| Joseph Klein III | Consejero | 1 de julio de 2026 A | 11 014 | 0 | 14 | $-9 356 036 |
| Lynne B Parshall | Consejero | 15 de abril de 2026 S | 51 344 | 0 | 6 | $-2 171 964 |
| Joseph H Wender | Consejero | 1 de diciembre de 2025 S | 36 035 | 0 | 13 | $-8 660 283 |
| MUTO FREDERICK T | Consejero | 15 de julio de 2022 M | 59 597 | 0 | 0 | $0 |
| Breaux Castleman | Consejero | 1 de julio de 2020 A | 19 183 | 0 | 0 | $0 |
| REED JOHN C | Consejero | 6 de septiembre de 2012 M | 0 | 0 | 0 | $0 |
| Richard D Dimarchi | Consejero | 1 de julio de 2010 A | — | 0 | 0 | $0 |
| GARIELI CHRISTOPHER | Consejero | 1 de julio de 2005 A | 155 431 | 0 | 0 | $0 |
| SKALETSKY MARK B | Consejero | 1 de julio de 2004 A | — | 0 | 0 | $0 |
| ISIS PHARMACEUTICALS INC | Propietario del 10% | 10 de octubre de 2020 P | 98 322 397 | 0 | 0 | $0 |
Informantes de las presentaciones SEC Form 3/4/5; neto = solo P/S de mercado abierto
Activistas y propietarios del %+ 5 5 tenencias
Inversores que presentaron el Anexo 13D de la SEC — propiedad beneficiosa superior al % 5 con la intención de influir en el emisor (participaciones activistas, campañas de la junta directiva, M&A). Cada fila muestra el estado conocido más reciente de la posición de ese declarante.
| Declarante | Presentado | Participación | Estado | Propósito | Presentación |
|---|---|---|---|---|---|
| Ionis Pharmaceuticals, Inc. (“Ionis”) ×8 presentaciones | 13 de octubre de 2020 | — | Presentación inicial | — | SEC |
| Isis Pharmaceuticals, Inc. (“ Isis ”) | 31 de julio de 2015 | — | Presentación inicial | — | SEC |
| Isis Pharmaceuticals, Inc. (“Isis”), Stanley T. Crooke (“Crooke”), B. Lynne Parshall (“Parshall”) ×2 presentaciones | 6 de noviembre de 2014 | — | Presentación inicial | — | SEC |
| Genzyme Corporation | 15 de enero de 2008 | — | Presentación inicial | Inversión pasiva | SEC |
| Persona informante no revelada | 12 de abril de 2001 | — | Presentación inicial | Inversión pasiva | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Propiedad de ETFs Mantenido por 85 ETFs
El peso refleja solo las tenencias directas de acciones (N-PORT); los fondos apalancados o basados en derivados pueden tener exposición adicional a swaps no mostrada.
| Fondo | Ponderación | Unidades | A fecha de | Fuente |
|---|---|---|---|---|
| ARKG · ARK ETF Trust | 1,74% | 288 230 NS | 30 de abril de 2026 | N-PORT |
| FXH · First Trust Exchange-Traded AlphaDE… | 1,72% | 201 598 NS | 30 de abril de 2026 | N-PORT |
| BBP · ETFis Series Trust I | 1,48% | 11 708 NS | 30 de abril de 2026 | N-PORT |
| GDOC · Goldman Sachs ETF Trust | 1,37% | 3 614 NS | 31 de mayo de 2026 | N-PORT |
| CGMM · Capital Group Equity ETF Trust I | 1,14% | 414 653 NS | 31 de mayo de 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0,94% | 64 911 NS | 30 de abril de 2026 | N-PORT |
| NUSC · Nushares ETF Trust | 0,87% | 150 398 NS | 30 de abril de 2026 | N-PORT |
| TAX · EA Series Trust | 0,87% | 2 885 NS | 29 de mayo de 2026 | N-PORT |
| JDOC · J.P. Morgan Exchange-Traded Fund Tr… | 0,84% | 1 257 NS | 30 de abril de 2026 | N-PORT |
| COPY · RBB Fund Trust | 0,84% | 37 653 NS | 31 de mayo de 2026 | N-PORT |
| HRTS · Tema ETF Trust | 0,83% | 5 599 NS | 31 de mayo de 2026 | N-PORT |
| IBB · iShares Trust | 0,68% | 1 189 984 SH | 8 de agosto de 2026 | Diario |
| FFND · Northern Lights Fund Trust II | 0,67% | 9 000 NS | 31 de mayo de 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,64% | 8 994 SH | 8 de agosto de 2026 | Diario |
| BIB · ProShares Trust | 0,63% | 6 109 NS | 31 de mayo de 2026 | N-PORT |
| MEDI · Harbor ETF Trust | 0,58% | 2 153 NS | 30 de abril de 2026 | N-PORT |
| FDMO · FIDELITY COVINGTON TRUST | 0,53% | 60 169 NS | 30 de abril de 2026 | N-PORT |
| FNY · First Trust Exchange-Traded AlphaDE… | 0,53% | 36 525 NS | 30 de abril de 2026 | N-PORT |
| OASC · Unified Series Trust | 0,47% | 5 182 NS | 31 de mayo de 2026 | N-PORT |
| QQQJ · Invesco Exchange-Traded Fund Trust … | 0,45% | 94 260 SH | 8 de agosto de 2026 | Diario |
| CGGR · Capital Group Growth ETF | 0,36% | 1 150 284 NS | 31 de mayo de 2026 | N-PORT |
| VBK · VANGUARD INDEX FUNDS | 0,34% | 2 078 639 SH | 8 de agosto de 2026 | Diario |
| SMMV · iShares Trust | 0,32% | 17 089 SH | 8 de agosto de 2026 | Diario |
| BKMC · BNY Mellon ETF Trust | 0,30% | 25 160 NS | 30 de abril de 2026 | N-PORT |
| ISCG · iShares Trust | 0,28% | 51 765 SH | 8 de agosto de 2026 | Diario |
| SCHA · SCHWAB STRATEGIC TRUST | 0,26% | 778 644 NS | 31 de mayo de 2026 | N-PORT |
| IWP · iShares Trust | 0,24% | 895 755 SH | 8 de agosto de 2026 | Diario |
| SCHM · SCHWAB STRATEGIC TRUST | 0,23% | 438 447 NS | 31 de mayo de 2026 | N-PORT |
| FSMD · FIDELITY COVINGTON TRUST | 0,23% | 71 810 NS | 30 de abril de 2026 | N-PORT |
| BBMC · J.P. Morgan Exchange-Traded Fund Tr… | 0,22% | 60 227 NS | 30 de abril de 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0,22% | 110 695 SH | 8 de agosto de 2026 | Diario |
| JMOM · J.P. Morgan Exchange-Traded Fund Tr… | 0,21% | 62 392 NS | 30 de abril de 2026 | N-PORT |
| FFLG · FIDELITY COVINGTON TRUST | 0,21% | 16 403 NS | 30 de abril de 2026 | N-PORT |
| FNX · First Trust Exchange-Traded AlphaDE… | 0,20% | 36 263 NS | 30 de abril de 2026 | N-PORT |
| VFMO · VANGUARD WELLINGTON FUND | 0,20% | 50 927 SH | 8 de agosto de 2026 | Diario |
| FHLC · FIDELITY COVINGTON TRUST | 0,19% | 70 978 NS | 30 de abril de 2026 | N-PORT |
| VHT · VANGUARD WORLD FUND | 0,18% | 471 609 SH | 8 de agosto de 2026 | Diario |
| SMLF · iShares Trust | 0,17% | 133 297 SH | 8 de agosto de 2026 | Diario |
| FAD · First Trust Exchange-Traded AlphaDE… | 0,16% | 10 044 NS | 30 de abril de 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0,15% | 1 895 610 SH | 8 de agosto de 2026 | Diario |
| VB · VANGUARD INDEX FUNDS | 0,15% | 3 600 281 SH | 8 de agosto de 2026 | Diario |
| ESML · iShares Trust | 0,15% | 78 764 SH | 8 de agosto de 2026 | Diario |
| IYH · iShares Trust | 0,15% | 98 412 SH | 8 de agosto de 2026 | Diario |
| NBCR · Neuberger Berman ETF Trust | 0,14% | 16 581 NS | 31 de mayo de 2026 | N-PORT |
| ISCB · iShares Trust | 0,14% | 7 328 SH | 8 de agosto de 2026 | Diario |
| AVIE · AMERICAN CENTURY ETF TRUST | 0,13% | 176 NS | 31 de mayo de 2026 | N-PORT |
| SMMD · iShares Trust | 0,12% | 81 988 SH | 8 de agosto de 2026 | Diario |
| WSML · iShares Trust | 0,08% | 9 548 SH | 8 de agosto de 2026 | Diario |
| LRND · New York Life Investments ETF Trust | 0,07% | 2 788 NS | 30 de abril de 2026 | N-PORT |
| EQAL · Invesco Exchange-Traded Fund Trust … | 0,07% | 9 928 SH | 8 de agosto de 2026 | Diario |