RYTM Rhythm Pharmaceuticals, Inc. - Common Stock
$109,79
Precio · Ago 21, 2026
Fundamentales a fecha de Ago 4, 2026
Rango 52S
$74–$122
74% of range
Calificación del Analista
BUY
22 analysts
Precio Objetivo
$142
+29% upside
P/E (TTM)
-35.3
ROE
-309.1%
Margen de Beneficio Neto
-103.6%
Acerca de Rhythm Pharmaceuticals, Inc. - Common Stock Descripción general de la empresa de Wikipedia
RYTM Instantánea de la Acción Precio, capitalización bursátil, P/E, BPA, ROE, deuda/capital, rango de 52 semanas
Precio
$109.79
Capitalización Bursátil
$7.38B
P/E (TTM)
-35.3
BPA (TTM)
$-3.11
Ingresos (TTM)
$190M
Rendimiento div.
—
ROE
-309.1%
Deuda/Capital
0.8
Rango 52S
$75 – $122
RYTM Gráfico del Precio de la Acción OHLCV diario con indicadores técnicos — desplace, amplíe y personalice su vista
Configure
Rendimiento a 10 años Tendencias de ingresos, beneficio neto, márgenes y BPA
Ingresos y Beneficio Neto
$190M
2016-12-31
→
2025-12-31
BPA
$-3.11
2019-12-31
→
2025-12-31
Flujo de caja libre
$-117M
2017-12-31
→
2025-12-31
Márgenes
-103.6%
Valoración Ratios P/E, P/S, P/B, EV/EBITDA: ¿está la acción cara o barata?
Métrica
Tendencia a 5 años
RYTM
Mediana de Pares
P/E (TTM)
-35.3
16.0
P/S (TTM) (P/V (TTM))
38.9
47.5
P/B (P/C)
53.1
8.5
EV / EBITDA
-37.1
—
Price / FCF (Precio / FCF)
-63.3
—
Rentabilidad Márgenes brutos, operativos y netos; ROE, ROA, ROIC
Métrica
Tendencia a 5 años
RYTM
Mediana de Pares
Operating Margin (Margen Operativo)
-101.2%
—
Net Profit Margin (Margen de Beneficio Neto)
-103.6%
-140.2%
ROA
-45.1%
-45.0%
ROE
-309.1%
-86.5%
ROIC
-77.9%
—
Salud financiera Deuda, liquidez, solvencia — solidez del balance general
Métrica
Tendencia a 5 años
RYTM
Mediana de Pares
Debt / Equity (Deuda / Patrimonio)
0.8
0.0
Current Ratio (Ratio corriente)
4.4
5.8
Quick Ratio (Ratio Rápido)
3.9
—
Crecimiento Crecimiento de ingresos, BPA y beneficio neto: interanual, CAGR a 3 años, CAGR a 5 años
Métrica
Tendencia a 5 años
RYTM
Mediana de Pares
Revenue YoY (Ingresos interanuales)
45.8%
—
Revenue CAGR 3Y (Ingresos CAGR 3A)
100.2%
—
Eficiencia de capital Rotación de activos, rotación de inventario, rotación de cuentas por cobrar
Métrica
Tendencia a 5 años
RYTM
Mediana de Pares
RYTM Consenso de analistas Opiniones de analistas alcistas y bajistas, precio objetivo a 12 meses, potencial alcista
COMPRA
22 analistas
- Compra fuerte 8 36,4%
- Compra 12 54,5%
- Mantener 2 9,1%
- Venta 0 0,0%
- Venta fuerte 0 0,0%
Precio objetivo a 12 meses
15 analistas · 2026-08-18
Mediana
$145.00
Ahora
$109.79
Mín
$105.00
Máx
$160.00
Objetivo mediano
$145.00
+32,1%
Objetivo medio
$141.53
+28,9%
Historial de Ganancias EPS real vs estimado, sorpresa %, tasa de aciertos, próxima fecha de resultados
Sorpresa Media
0.00%
| Período | EPS Actual | EPS est. | Sorpresa |
|---|---|---|---|
| 30 de junio de 2026 | $-0.73 | $-0.84 | 0.11% |
| 31 de marzo de 2026 | $-0.83 | $-0.87 | 0.04% |
| 31 de diciembre de 2025 | $-0.73 | $-0.84 | 0.11% |
| 30 de septiembre de 2025 | $-0.82 | $-0.74 | -0.08% |
| 30 de junio de 2025 | $-0.75 | $-0.69 | -0.06% |
| 31 de marzo de 2025 | $-0.81 | $-0.72 | -0.09% |
Comparación de pares (subindustria GICS) Métricas clave frente a competidores del sector
| Ticker | Capitalización Bursátil | P/E | Ingresos interanuales | Margen Neto | ROE | Margen Bruto |
|---|---|---|---|---|---|---|
| RYTM | $7.19B | -34.4 | 45.8% | -103.6% | -309.1% | — |
| TWST | $1.71B | -21.6 | 20.3% | -20.6% | -17.0% | — |
| IBRX | $2.00B | -5.2 | 668.3% | -310.2% | 71.0% | — |
| TGTX | $4.63B | 10.8 | 87.3% | 72.6% | 96.7% | — |
| ORKA | $1.48B | -3.3 | — | — | -25.9% | — |
| CAI | $7.62B | -8.4 | 97.0% | -8.4% | -13.2% | — |
| CGON | $3.35B | -20.0 | 254.7% | -3985.0% | -22.6% | — |
Fundamentales Completos Todas las métricas por año — estado de resultados, balance general, flujo de caja
Estado de resultados 17
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $190M | $130M | $77M | $24M | $3M | $0 | $0 | $0 | $0 | $0 | |
| Cost of Revenue | $19M | $13M | $9M | $2M | $599.0K | · | · | · | · | · | |
| R&D Expense | $167M | $238M | $135M | $109M | $104M | $90M | $109M | $50M | $23M | $20M | |
| SG&A Expense | $195M | $144M | $118M | $92M | $68M | $46M | $37M | $28M | $10M | $6M | |
| Operating Expenses | $382M | $396M | $262M | $203M | $173M | $137M | $146M | $78M | $32M | $26M | |
| Operating Income | $-192M | $-266M | $-184M | $-179M | $-170M | $-137M | $-146M | $-78M | $-32M | $-26M | |
| Interest Expense | · | · | $14M | $5M | · | · | · | · | · | · | |
| Interest Income | · | · | · | · | $447.0K | $3M | $5M | $4M | $566.0K | $33.0K | |
| Other Non-op | $1M | $2M | $190.0K | $-790.0K | $100M | $3M | $5M | $4M | $-1M | $33.0K | |
| Pretax Income | $-196M | $-260M | $-184M | $-181M | $-70M | · | · | · | · | · | |
| Income Tax | $497.0K | $346.0K | $564.0K | · | · | · | · | · | · | · | |
| Net Income | $-197M | $-261M | $-185M | $-181M | $-70M | $-134M | $-141M | $-74M | $-34M | $-26M | |
| EPS (Basic) | $-3.11 | $-4.34 | $-3.20 | $-3.47 | $-1.40 | $-3.04 | $-3.86 | · | · | · | |
| EPS (Diluted) | $-3.11 | $-4.34 | $-3.20 | $-3.47 | $-1.40 | $-3.04 | $-3.86 | · | · | · | |
| Shares (Basic) | 64,984,361 | 60,995,204 | 57,673,128 | 52,120,701 | 49,600,294 | 44,127,220 | 36,422,450 | · | · | · | |
| Shares (Diluted) | 64,984,361 | 60,995,204 | 57,673,128 | 52,120,701 | 49,600,294 | 44,127,220 | 36,422,450 | · | · | · | |
| EBITDA | $-192M | $-265M | $-183M | $-178M | $-169M | $-136M | $-145M | $-78M | $-32M | · |
Balance general 27
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $54M | $89M | $60M | $128M | $59M | $101M | $62M | $50M | $34M | $7M | |
| Short-term Investments | $335M | $231M | $216M | $206M | $236M | $72M | $230M | · | $114M | $4M | |
| Receivables | $26M | $19M | $15M | $6M | $1M | · | · | · | · | · | |
| Inventory | $26M | $19M | $9M | $3M | $111.0K | · | · | · | · | · | |
| Prepaid Expense | $26M | $16M | $9M | $12M | $12M | $9M | $10M | $7M | $3M | $638.0K | |
| Other Current Assets | $10M | $9M | $7M | $7M | $4M | $3M | $4M | $1M | $1M | $216.0K | |
| Current Assets | $467M | $374M | $308M | $354M | $308M | $182M | $302M | $259M | $151M | $11M | |
| PP&E (Net) | $1M | $632.0K | $1M | $2M | $3M | $3M | $4M | $1M | $840.0K | $930.0K | |
| PP&E (Gross) | $6M | $5M | $5M | $5M | $5M | $5M | $4M | $2M | $1M | $1M | |
| Accum. Depreciation | $5M | $5M | $4M | $3M | $2M | $1M | $752.0K | $809.0K | $367.0K | $144.0K | |
| Intangibles | $5M | $6M | $7M | $8M | $5M | · | · | · | · | · | |
| Other Non-current Assets | $3M | $7M | $15M | $17M | · | · | · | · | · | · | |
| Total Assets | $480M | $392M | $333M | $382M | $330M | $187M | $309M | $260M | $152M | $12M | |
| Accounts Payable | $14M | $12M | $5M | $5M | $6M | $5M | $10M | $8M | $2M | $2M | |
| Accrued Liabilities | $84M | $63M | $48M | $33M | $30M | $13M | $14M | $6M | $4M | $3M | |
| Current Liabilities | $106M | $116M | $55M | $40M | $43M | $18M | $24M | $14M | $7M | $5M | |
| Capital Leases | $3M | $4M | $490.0K | $1M | $2M | · | · | · | · | · | |
| Total Liabilities | $210M | $228M | $163M | $118M | $45M | $21M | $28M | $14M | $7M | $5M | |
| Long-term Debt | $108M | $110M | · | · | · | · | · | · | · | · | |
| Total Debt | $108M | $110M | · | · | · | · | · | · | · | · | |
| Common Stock | $67.0K | $61.0K | $59.0K | $56.0K | $50.0K | $44.0K | $44.0K | $34.0K | $27.0K | $10.0K | |
| Paid-in Capital | $1.49B | $1.18B | $1.06B | $974M | $813M | $626M | $606M | $431M | $255M | $44M | |
| Retained Earnings | $-1.35B | $-1.16B | $-895M | $-710M | $-529M | $-459M | $-325M | $-185M | $-110M | $-77M | |
| AOCI | $-796.0K | $-39.0K | $134.0K | $-92.0K | $-1.0K | $49.0K | · | · | · | · | |
| Stockholders' Equity | $139M | $22M | $170M | $264M | $284M | $167M | $281M | $246M | $145M | $-33M | |
| Liabilities + Equity | $480M | $392M | $333M | $382M | $330M | $187M | $309M | $260M | $152M | $12M | |
| Shares Outstanding | 67,205,321 | 62,390,654 | 59,426,559 | 56,612,429 | 50,283,574 | 44,235,903 | 43,996,753 | 34,410,725 | 27,284,140 | 10,196,292 |
Flujo de Efectivo 16
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $500.0K | $700.0K | $900.0K | $896.0K | $816.0K | $690.0K | $834.0K | $442.0K | $223.0K | $144.0K | |
| Stock-based Comp | $67M | $40M | $33M | $20M | $21M | $17M | $12M | $6M | $2M | $1M | |
| Deferred Tax | $0 | $0 | $0 | · | · | · | · | $0 | $0 | $0 | |
| Amort. of Intangibles | · | · | $855.0K | $774.0K | $342.0K | · | · | · | · | · | |
| Other Non-cash | $14M | $106M | $15M | $-13M | $-98M | $-6M | $5M | $5M | $2M | · | |
| Operating Cash Flow | $-116M | $-114M | $-136M | $-173M | $-146M | $-122M | $-123M | $-62M | $-29M | $-23M | |
| CapEx | $953.0K | $0 | $47.0K | $281.0K | $434.0K | $214.0K | $3M | $722.0K | $133.0K | $1M | |
| Investing Cash Flow | $-137M | $-48M | $-6M | $28M | $-62M | $159M | $-28M | $-87M | $-110M | $-5M | |
| Debt Issued | $0 | $0 | $24M | $72M | · | · | · | · | · | · | |
| Net Debt Issued | $-20M | $-13M | $17M | $72M | · | · | · | · | · | · | |
| Stock Issued | $34M | $39M | $49M | $131M | $162M | · | $161M | $163M | $126M | · | |
| Net Stock Activity | $34M | $39M | $49M | $131M | $162M | · | $161M | $163M | $126M | · | |
| Financing Cash Flow | $218M | $191M | $74M | $214M | $166M | $2M | $163M | $165M | $167M | · | |
| Net Change in Cash | $-35M | $29M | $-68M | $68M | $-42M | $39M | $13M | $15M | $28M | $-28M | |
| Free Cash Flow | $-117M | · | $-136M | $-174M | $-146M | $-122M | $-126M | $-63M | $-30M | · | |
| Levered FCF | · | · | $-150M | · | · | · | · | · | · | · |
Rentabilidad 7
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -101.2% | -204.0% | -238.1% | -757.9% | -5391.9% | · | · | · | · | · | |
| Net Margin | -103.6% | -200.3% | -238.5% | -766.2% | -2207.1% | · | · | · | · | · | |
| Pretax Margin | -103.3% | -200.0% | -237.8% | · | · | · | · | · | · | · | |
| EBITDA Margin | -100.9% | -203.5% | -236.9% | -754.1% | -5366.0% | · | · | · | · | · | |
| ROA | -45.1% | -71.9% | -51.6% | -50.9% | -27.0% | -54.1% | -49.5% | -36.0% | -41.1% | · | |
| ROE | -309.1% | -1582.1% | -100.6% | -66.4% | -23.0% | -73.7% | -65.4% | -28.7% | -60.2% | · | |
| ROIC | -77.9% | -202.1% | -108.9% | · | · | · | · | · | · | · |
Liquidez y Solvencia 5
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 4.4 | 3.2 | 5.6 | 8.9 | 7.1 | 10.1 | 12.4 | 19.0 | 22.4 | · | |
| Quick Ratio | 3.9 | 2.9 | 5.3 | 8.5 | 6.8 | 9.6 | 2.6 | 3.6 | 22.0 | · | |
| Debt / Equity | 0.8 | 5.1 | · | · | · | · | · | · | · | · | |
| LT Debt / Equity | 0.7 | 5.0 | · | · | · | · | · | · | · | · | |
| Interest Coverage | · | · | -13.3 | -34.4 | · | · | · | · | · | · |
Eficiencia 3
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.4 | 0.4 | 0.2 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | · | |
| Inventory Turnover | 0.9 | 1.0 | 1.6 | 1.4 | 10.8 | · | · | · | · | · | |
| Receivables Turnover | 8.5 | 7.8 | 7.3 | 6.5 | 6.2 | · | · | · | · | · |
Tasas de Crecimiento 2
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue YoY | 45.8% | 68.1% | 227.6% | 649.5% | · | · | · | · | · | · | |
| Revenue CAGR 3Y | 100.2% | 245.5% | · | · | · | · | · | · | · | · |
Valoración (TTM) 14
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $190M | $130M | $77M | $24M | $3M | $0 | $0 | $0 | $0 | · | |
| Net Income TTM | $-197M | $-261M | $-185M | $-181M | $-70M | $-134M | $-141M | $-74M | $-34M | · | |
| Market Cap | $7.19B | $3.49B | $2.73B | $1.65B | $502M | $1.32B | $1.01B | $925M | $793M | · | |
| Enterprise Value | $6.91B | $3.28B | · | · | · | · | · | · | · | · | |
| P/E | -34.4 | -12.9 | -14.4 | -8.4 | -7.1 | -9.8 | -5.9 | · | · | · | |
| P/S | 37.9 | 26.8 | 35.3 | 69.7 | 159.1 | · | · | · | · | · | |
| P/B | 51.7 | 160.7 | 16.1 | 6.2 | 1.8 | 7.9 | 3.6 | 3.8 | 5.5 | · | |
| P / Tangible Book | 53.8 | 224.5 | 16.8 | 6.4 | 1.8 | 7.9 | · | · | · | · | |
| P / Cash Flow | -62.2 | -30.7 | -20.1 | -9.5 | -3.4 | -10.8 | -8.2 | -14.9 | -26.9 | · | |
| P / FCF | -61.7 | · | -20.1 | -9.5 | -3.4 | -10.8 | -8.0 | -14.7 | -26.8 | · | |
| EV / EBITDA | -36.1 | -12.4 | · | · | · | · | · | · | · | · | |
| EV / FCF | -59.3 | · | · | · | · | · | · | · | · | · | |
| EV / Revenue | 36.4 | 25.2 | · | · | · | · | · | · | · | · | |
| Earnings Yield | -2.9% | -7.8% | -7.0% | -11.9% | -14.0% | -10.2% | -16.8% | · | · | · |
Estado de resultados 16
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $71M | $60M | $57M | $51M | $49M | $33M | $42M | $33M | $29M | $26M | $24M | $23M | $19M | $11M | $9M | $4M | |
| Cost of Revenue | $9M | $7M | $5M | $5M | $6M | $4M | $4M | $4M | $3M | $3M | $3M | $2M | $2M | $1M | $1M | $497.0K | |
| R&D Expense | $43M | $42M | $42M | $46M | $42M | $37M | $41M | $38M | $30M | $129M | $30M | $34M | $34M | $38M | $24M | $21M | |
| SG&A Expense | $67M | $64M | $57M | $52M | $46M | $39M | $38M | $35M | $36M | $34M | $32M | $30M | $30M | $25M | $26M | $22M | |
| Operating Expenses | $120M | $112M | $104M | $104M | $94M | $80M | $83M | $77M | $70M | $166M | $66M | $66M | $66M | $64M | $51M | $44M | |
| Operating Income | $-49M | $-52M | $-47M | $-53M | $-45M | $-47M | $-41M | $-44M | $-40M | $-140M | $-41M | $-44M | $-47M | $-53M | $-42M | $-39M | |
| Interest Expense | · | · | · | · | · | · | · | · | · | $5M | · | $3M | $3M | $3M | · | $2M | |
| Other Non-op | $1M | $-2M | $58.0K | $274.0K | $2M | $-644.0K | $325.0K | $1M | $302.0K | $524.0K | $393.0K | $-159.0K | $-17.0K | $-27.0K | $-54.0K | $-370.0K | |
| Pretax Income | $-49M | $-55M | $-48M | $-53M | $-46M | $-49M | $-43M | $-44M | $-32M | $-141M | $-41M | $-44M | $-47M | $-52M | $-42M | $-41M | |
| Income Tax | $444.0K | $545.0K | $-31.0K | $111.0K | $337.0K | $80.0K | $-89.0K | $-344.0K | $479.0K | $300.0K | $196.0K | $368.0K | $0 | $0 | · | · | |
| Net Income | $-49M | $-56M | $-48M | $-53M | $-47M | $-49M | $-43M | $-44M | $-32M | $-141M | $-42M | $-44M | $-47M | $-52M | $-42M | $-41M | |
| EPS (Basic) | $-0.73 | $-0.83 | $-0.73 | $-0.82 | $-0.75 | $-0.81 | $-0.71 | $-0.73 | $-0.55 | $-2.35 | $-0.70 | $-0.76 | $-0.82 | $-0.92 | $-0.74 | $-0.79 | |
| EPS (Diluted) | $-0.73 | $-0.83 | $-0.73 | $-0.82 | $-0.75 | $-0.81 | $-0.71 | $-0.73 | $-0.55 | $-2.35 | $-0.70 | $-0.76 | $-0.82 | $-0.92 | · | $-0.79 | |
| Shares (Basic) | 68,592,661 | 67,974,193 | -128,020,218 | 66,261,055 | 63,684,359 | 63,059,165 | -121,380,096 | 61,219,918 | 61,011,824 | 60,143,558 | -113,778,469 | 57,874,960 | 56,867,662 | 56,708,975 | -100,004,851 | 51,400,922 | |
| Shares (Diluted) | 68,592,661 | 67,974,193 | -128,020,218 | 66,261,055 | 63,684,359 | 63,059,165 | -121,380,096 | 61,219,918 | 61,011,824 | 60,143,558 | -113,778,469 | 57,874,960 | 56,867,662 | 56,708,975 | · | 51,400,922 | |
| EBITDA | $-49M | $-52M | · | $-53M | $-45M | $-47M | · | $-44M | · | $-140M | · | $-44M | $-47M | $-53M | · | $-39M |
Balance general 28
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $66M | $62M | $54M | $52M | $136M | $106M | $89M | $48M | $162M | $53M | · | $65M | $116M | $110M | · | $185M | |
| Short-term Investments | $265M | $278M | $335M | $364M | $155M | $208M | $231M | $251M | $157M | $148M | · | $235M | $138M | $185M | · | $163M | |
| Receivables | $40M | $34M | $26M | $33M | $26M | $18M | $19M | $19M | $18M | $15M | · | $15M | $14M | $8M | · | $3M | |
| Inventory | $31M | $29M | $26M | $22M | $19M | $19M | $19M | $14M | $12M | $9M | · | $8M | $6M | $5M | · | · | |
| Prepaid Expense | $25M | $27M | $26M | $24M | $25M | $18M | $16M | $9M | $9M | $11M | · | $8M | $10M | $10M | · | $11M | |
| Other Current Assets | · | · | $10M | · | · | · | $9M | · | · | · | · | · | · | · | · | · | |
| Current Assets | $427M | $430M | $467M | $495M | $361M | $369M | $374M | $340M | $357M | $236M | · | $329M | $284M | $318M | · | $362M | |
| PP&E (Net) | $103.0K | $1M | $1M | $237.0K | $297.0K | $462.0K | $632.0K | $801.0K | $973.0K | $1M | · | $2M | $2M | $2M | · | $2M | |
| PP&E (Gross) | · | · | $6M | · | · | · | $5M | · | · | · | · | · | · | · | · | · | |
| Accum. Depreciation | · | · | $5M | · | · | · | $5M | · | · | · | · | · | · | · | · | · | |
| Intangibles | $5M | $5M | $5M | $6M | $6M | $6M | $6M | $6M | $7M | $7M | · | $7M | $7M | $8M | · | $8M | |
| Other Non-current Assets | · | · | $3M | · | · | · | $7M | · | · | · | · | · | · | · | · | · | |
| Total Assets | $437M | $442M | $480M | $507M | $373M | $387M | $392M | $364M | $382M | $259M | · | $354M | $310M | $346M | · | $390M | |
| Accounts Payable | $16M | $12M | $14M | $14M | $16M | $12M | $12M | $5M | $5M | $8M | · | $4M | $8M | $13M | · | $5M | |
| Accrued Liabilities | · | · | $84M | · | · | $59M | $63M | $55M | $48M | $45M | · | $44M | $36M | $31M | · | $26M | |
| Current Liabilities | $124M | $103M | $106M | $104M | $129M | $112M | $116M | $98M | $55M | $54M | · | $50M | $46M | $46M | · | $33M | |
| Capital Leases | $3M | $3M | $3M | $4M | $4M | $4M | $4M | $4M | $3M | $284.0K | · | $692.0K | $888.0K | $1M | · | $1M | |
| Other Non-current Liabilities | · | · | · | · | · | · | · | · | $36M | $35M | · | · | · | · | · | · | |
| Total Liabilities | $220M | $205M | $210M | $211M | $239M | $224M | $228M | $211M | $202M | $197M | · | $157M | $128M | $126M | · | $108M | |
| Long-term Debt | $106M | $108M | $108M | $109M | $110M | $110M | $110M | · | · | · | · | · | · | · | · | $73M | |
| Total Debt | $106M | $108M | · | $109M | $110M | $110M | · | · | · | · | · | · | · | · | · | · | |
| Common Stock | $69.0K | $69.0K | $67.0K | $67.0K | $64.0K | $62.0K | $61.0K | $61.0K | $60.0K | $60.0K | · | $59.0K | $57.0K | $56.0K | · | $56.0K | |
| Paid-in Capital | $1.56B | $1.53B | $1.49B | $1.45B | $1.24B | $1.22B | $1.18B | $1.12B | $1.11B | $1.10B | · | $1.05B | $991M | $982M | · | $949M | |
| Retained Earnings | $-1.46B | $-1.41B | $-1.35B | $-1.30B | $-1.25B | $-1.20B | $-1.16B | $-1.11B | $-1.07B | $-1.04B | · | $-853M | $-809M | $-762M | · | $-668M | |
| AOCI | $-912.0K | $444.0K | $-796.0K | $-926.0K | $-2M | $-51.0K | $-39.0K | $-604.0K | $-617.0K | $-181.0K | · | $-113.0K | $-14.0K | $-6.0K | · | $-339.0K | |
| Stockholders' Equity | $103M | $123M | $139M | $149M | $-12M | $19M | $22M | $11M | $39M | $62M | $170M | $197M | $182M | $220M | $264M | $281M | |
| Liabilities + Equity | $437M | $442M | $480M | $507M | $373M | $387M | $392M | $364M | $382M | $259M | · | $354M | $310M | $346M | · | $390M | |
| Shares Outstanding | 68,816,868 | 68,445,084 | 67,205,321 | 66,684,077 | 63,913,185 | 63,494,892 | 62,390,654 | 61,436,251 | 61,095,949 | 60,964,468 | · | 59,089,352 | 56,896,068 | 56,852,404 | · | 55,756,256 |
Flujo de Efectivo 12
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $26M | $23M | $19M | $19M | $16M | $13M | $11M | $11M | $10M | $8M | $9M | $9M | $9M | $6M | $5M | $5M | |
| Amort. of Intangibles | · | · | · | · | · | · | · | · | · | · | · | · | · | $214.0K | · | $214.0K | |
| Operating Cash Flow | $-9M | $-44M | $-25M | $-27M | $-23M | $-40M | $-19M | $-25M | $-29M | $-41M | $-29M | $-29M | $-41M | $-36M | $-34M | $-47M | |
| CapEx | · | · | · | · | · | · | · | · | · | · | $-1.0K | $1.0K | $0 | $47.0K | $-1.0K | $95.0K | |
| Investing Cash Flow | $14M | $57M | $30M | $-246M | $54M | $25M | $21M | $-91M | $-9M | $30M | $23M | $-95M | $48M | $18M | $-41M | $-40M | |
| Debt Issued | · | · | · | · | · | · | · | · | · | · | $0 | · | · | · | $-3M | $38M | |
| Net Debt Issued | · | $-4M | · | · | · | $-5M | · | · | · | $-3M | · | · | · | $-1M | · | · | |
| Stock Issued | $0 | $0 | · | · | $0 | $34M | · | · | · | · | $0 | · | · | · | $14M | · | |
| Net Stock Activity | · | $0 | · | · | · | $34M | · | · | · | · | · | · | · | · | · | · | |
| Financing Cash Flow | $-1M | $-5M | $-3M | $189M | $-889.0K | $32M | $38M | $2M | $146M | $4M | $2M | $73M | $-965.0K | $-133.0K | $17M | $159M | |
| Net Change in Cash | $3M | $8M | $2M | $-83M | $30M | $17M | $42M | $-114M | $108M | $-7M | $-5M | $-51M | $6M | $-18M | $-57M | $72M | |
| Free Cash Flow | · | · | · | · | · | · | · | · | · | · | · | · | · | $-36M | · | · |
Rentabilidad 7
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -68.1% | -87.1% | · | -102.6% | -93.4% | -143.7% | · | -132.0% | · | -538.7% | · | -195.3% | -242.5% | -458.0% | · | · | |
| Net Margin | -69.2% | -92.6% | · | -103.1% | -96.1% | -151.3% | · | -131.2% | · | -544.4% | · | -196.2% | -243.0% | -455.0% | · | · | |
| Pretax Margin | -68.6% | -91.6% | · | -102.9% | -95.5% | -151.1% | · | -132.3% | · | -543.3% | · | -194.6% | · | · | · | · | |
| EBITDA Margin | -68.1% | -87.1% | · | -102.6% | -93.4% | -143.7% | · | -132.0% | · | -538.7% | · | -195.3% | -242.5% | -458.0% | · | · | |
| ROA | -12.2% | -13.4% | · | -12.2% | -12.4% | -15.3% | · | -12.2% | · | -46.8% | · | -11.9% | -15.9% | -16.6% | · | -11.0% | |
| ROE | -108.3% | -78.5% | · | -66.1% | -340.0% | -122.9% | · | -41.8% | · | -100.5% | · | -18.4% | -24.7% | -22.9% | · | -13.5% | |
| ROIC | -23.4% | -22.9% | · | -20.5% | -46.6% | -36.6% | · | -388.2% | · | -227.6% | · | -22.4% | · | · | · | · |
Liquidez y Solvencia 5
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 3.5 | 4.2 | · | 4.7 | 2.8 | 3.3 | · | 3.5 | · | 4.4 | · | 6.6 | 6.2 | 6.9 | · | 10.9 | |
| Quick Ratio | 3.0 | 3.6 | · | 4.3 | 2.4 | 3.0 | · | 3.3 | · | 4.0 | · | 6.3 | 5.8 | 6.6 | · | 10.6 | |
| Debt / Equity | 1.0 | 0.9 | · | 0.7 | -9.2 | 5.8 | · | · | · | · | · | · | · | · | · | · | |
| LT Debt / Equity | 0.9 | 0.8 | · | 0.7 | -8.9 | 5.7 | · | · | · | · | · | · | · | · | · | · | |
| Interest Coverage | · | · | · | · | · | · | · | · | · | -29.4 | · | -14.0 | -14.1 | -17.2 | · | -18.3 |
Eficiencia 3
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.2 | 0.1 | · | 0.1 | 0.1 | 0.1 | · | 0.1 | · | 0.1 | · | 0.1 | 0.1 | 0.0 | · | · | |
| Inventory Turnover | 0.4 | 0.3 | · | 0.3 | 0.4 | 0.3 | · | 0.4 | · | 0.4 | · | 0.6 | 0.7 | 0.5 | · | · | |
| Receivables Turnover | 2.1 | 2.3 | · | 2.0 | 2.2 | 2.0 | · | 2.0 | · | 2.3 | · | 2.5 | 2.5 | 2.6 | · | · |
Valoración (TTM) 13
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $231M | $193M | · | $166M | $144M | $121M | · | $111M | $97M | $79M | · | $57M | $44M | $26M | · | $16M | |
| Net Income TTM | $-204M | $-205M | · | $-193M | $-172M | $-267M | · | $-261M | $-264M | $-284M | · | $-184M | $-185M | $-191M | · | $-174M | |
| Market Cap | $7.64B | $5.95B | · | $6.73B | $4.04B | $3.36B | · | $3.22B | · | $2.64B | · | $1.35B | $938M | $1.01B | · | $1.37B | |
| Enterprise Value | $7.42B | $5.72B | · | $6.43B | $3.86B | $3.16B | · | · | · | · | · | · | · | · | · | · | |
| P/E | -35.5 | -27.1 | · | -32.5 | -22.2 | -11.9 | · | -11.9 | -9.2 | -8.9 | · | -7.0 | -4.8 | -4.9 | · | -7.1 | |
| P/S | 33.1 | 30.9 | · | 40.6 | 28.1 | 27.8 | · | 29.0 | · | 33.4 | · | 23.6 | 21.3 | 38.5 | · | 86.0 | |
| P/B | 74.2 | 48.4 | · | 45.3 | -339.2 | 177.5 | · | 287.0 | · | 42.9 | · | 6.9 | 5.1 | 4.6 | · | 4.9 | |
| P / Tangible Book | 77.9 | 50.5 | · | 47.0 | · | 259.0 | · | 666.8 | 76.6 | 48.2 | · | 7.1 | 5.4 | 4.8 | · | 5.0 | |
| P / Cash Flow | · | -134.7 | · | · | · | -83.4 | · | · | · | -64.8 | · | · | · | -27.8 | · | · | |
| P / FCF | · | · | · | · | · | · | · | · | · | · | · | · | · | -27.8 | · | · | |
| EV / EBITDA | -152.7 | -109.3 | · | -122.1 | -85.2 | -67.2 | · | · | · | · | · | · | · | · | · | · | |
| EV / Revenue | 32.1 | 29.7 | · | 38.8 | 26.9 | 26.1 | · | · | · | · | · | · | · | · | · | · | |
| Earnings Yield | -2.8% | -3.7% | · | -3.1% | -4.5% | -8.4% | · | -8.4% | -10.9% | -11.2% | · | -14.3% | -20.7% | -20.5% | · | -14.0% |
Estados Financieros Estado de resultados, balance general, flujo de caja — anual, últimos 5 años
Estado de resultados
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Ingresos | $190M | $130M | $77M | $24M | $3M |
| Margen Operativo % | -101.2% | -204.0% | -238.1% | -757.9% | -5391.9% |
| Beneficio neto | $-197M | $-261M | $-185M | $-181M | $-70M |
| EPS Diluido | $-3.11 | $-4.34 | $-3.20 | $-3.47 | $-1.40 |
Balance general
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Deuda / Patrimonio | 0.8 | 5.1 | — | — | — |
| Ratio corriente | 4.4 | 3.2 | 5.6 | 8.9 | 7.1 |
| Ratio Rápido | 3.9 | 2.9 | 5.3 | 8.5 | 6.8 |
Flujo de Efectivo
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Flujo de caja libre | $-117M | — | $-136M | $-174M | $-146M |
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Propietarios institucionales (13F) 320 declarantes · $7.0B total · A fecha de 30 de junio de 2026
Instituciones que informan tener esta acción en su Formulario 13F trimestral de la SEC. Solo posiciones largas; un solo presentador puede aparecer dos veces para tramos de opciones separados. Las patas de put/call de compensación grandes suelen reflejar la creación de mercado o el inventario cubierto, no la convicción direccional.
Actividad institucional — Q2 2026 vs trimestre anterior
| Nuevas posiciones | Posiciones cerradas | Aumentado | Disminuido | Cambio neto de acciones |
|---|---|---|---|---|
| 57 (-9 vs trimestre anterior) | 38 (-8 vs trimestre anterior) | 105 (+2 vs trimestre anterior) | 95 (+11 vs trimestre anterior) | +2.6M |
Comparado con Q1 2026. Las presentaciones del Formulario 13F de la SEC vencen dentro de los 45 días posteriores al final del trimestre, más un pequeño margen para los presentadores tardíos; los trimestres que aún se encuentran dentro de esa ventana se omiten en favor del par más reciente completamente reportado.
| Institución | Valor | Acciones | % de 13F rastreadas | Tipo |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $740 218 912 | 6 666 837 | 10,63% | Acciones |
| BAKER BROS. ADVISORS LP | $622 265 747 | 5 604 483 | 8,94% | Acciones |
| VANGUARD GROUP INC | $612 335 379 | 5 720 622 | 8,80% | Acciones |
| PRIMECAP MANAGEMENT CO/CA/ | $351 837 748 | 3 168 853 | 5,05% | Acciones |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $348 289 452 | 3 136 895 | 5,00% | Acciones |
| VANGUARD CAPITAL MANAGEMENT LLC | $333 753 626 | 3 005 977 | 4,79% | Acciones |
| PERCEPTIVE ADVISORS LLC | $287 156 334 | 2 586 295 | 4,12% | Acciones |
| STATE STREET CORP | $285 728 722 | 2 573 529 | 4,10% | Acciones |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $245 220 303 | 2 208 595 | 3,52% | Acciones |
| Polar Capital Holdings Plc | $184 713 061 | 1 663 632 | 2,65% | Acciones |
| GOLDMAN SACHS GROUP INC | $181 683 274 | 1 636 344 | 2,61% | Acciones |
| Capital Research Global Investors | $170 131 602 | 1 532 303 | 2,44% | Acciones |
| GEODE CAPITAL MANAGEMENT, LLC | $145 911 779 | 1 313 860 | 2,10% | Acciones |
| CITADEL ADVISORS LLC | $140 303 282 | 1 263 652 | 2,02% | Acciones |
| Checkpoint Capital L.P. | $131 681 580 | 1 186 000 | 1,89% | Acciones |
| Siren, L.L.C. | $126 160 613 | 1 136 275 | 1,81% | Acciones |
| Pictet Asset Management Holding SA | $106 252 095 | 957 785 | 1,53% | Acciones |
| MORGAN STANLEY | $94 763 217 | 853 492 | 1,36% | Acciones |
| FMR LLC | $89 815 609 | 808 931 | 1,29% | Acciones |
| Woodline Partners LP | $84 259 668 | 758 891 | 1,21% | Acciones |
| ALLIANCEBERNSTEIN L.P. | $77 814 059 | 894 723 | 1,12% | Acciones |
| Clearbridge Investments, LLC | $77 329 368 | 696 473 | 1,11% | Acciones |
| Rock Springs Capital Management LP | $76 899 156 | 692 598 | 1,10% | Acciones |
| NORGES BANK | $76 149 259 | 685 844 | 1,09% | Acciones |
| Integral Health Asset Management, LLC | $61 066 500 | 550 000 | 0,88% | Acciones |
| VANGUARD FIDUCIARY TRUST CO | $49 488 625 | 445 723 | 0,71% | Acciones |
| Candriam S.C.A. | $48 032 508 | 433 025 | 0,69% | Acciones |
| Squarepoint Ops LLC | $46 956 919 | 422 921 | 0,67% | Acciones |
| Point72 Asset Management, L.P. | $45 989 736 | 414 210 | 0,66% | Acciones |
| Sofinnova Investments, Inc. | $45 303 238 | 408 027 | 0,65% | Acciones |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $44 078 910 | 397 000 | 0,63% | Acciones |
| BRAIDWELL LP | $42 316 642 | 381 128 | 0,61% | Acciones |
| LOOMIS SAYLES & CO L P | $40 081 941 | 361 001 | 0,58% | Acciones |
| Artisan Partners Limited Partnership | $39 395 220 | 354 816 | 0,57% | Acciones |
| AMERIPRISE FINANCIAL INC | $38 809 678 | 349 540 | 0,56% | Acciones |
| ORBIMED ADVISORS LLC | $35 851 587 | 322 900 | 0,52% | Acciones |
| MILLENNIUM MANAGEMENT LLC | $35 165 311 | 316 719 | 0,51% | Acciones |
| WELLINGTON MANAGEMENT GROUP LLP | $35 155 873 | 316 634 | 0,51% | Acciones |
| SILVERARC CAPITAL MANAGEMENT, LLC | $34 581 515 | 311 461 | 0,50% | Acciones |
| Capital World Investors | $24 587 594 | 221 450 | 0,35% | Acciones |
| BNP PARIBAS FINANCIAL MARKETS | $21 914 435 | 197 374 | 0,31% | Acciones |
| KENNEDY CAPITAL MANAGEMENT LLC | $21 452 661 | 193 215 | 0,31% | Acciones |
| Assenagon Asset Management S.A. | $20 706 096 | 186 491 | 0,30% | Acciones |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $17 616 744 | 160 094 | 0,25% | Acciones |
| First Turn Management, LLC | $17 100 619 | 154 018 | 0,25% | Acciones |
| NEW YORK STATE COMMON RETIREMENT FUND | $16 449 317 | 148 152 | 0,24% | Acciones |
| BANK OF AMERICA CORP /DE/ | $16 099 572 | 145 002 | 0,23% | Acciones |
| Nicholas Investment Partners, LP | $15 463 148 | 139 270 | 0,22% | Acciones |
| ADAR1 Capital Management, LLC | $15 117 623 | 136 158 | 0,22% | Acciones |
| Connor, Clark & Lunn Investment Management Ltd. | $15 085 313 | 135 867 | 0,22% | Acciones |
| Qube Research & Technologies Ltd | $14 923 542 | 134 410 | 0,21% | Acciones |
| NEXTBio Capital Management LP | $14 629 091 | 131 758 | 0,21% | Acciones |
| BlackRock, Inc. | $14 611 659 | 131 601 | 0,21% | Acciones |
| Driehaus Capital Management LLC | $14 354 514 | 129 285 | 0,21% | Acciones |
| SummitTX Capital, L.P. | $14 034 303 | 126 401 | 0,20% | Acciones |
| Logos Global Management LP | $13 878 750 | 125 000 | 0,20% | Acciones |
| Opaleye Management Inc. | $13 601 175 | 122 500 | 0,20% | Acciones |
| SEGALL BRYANT & HAMILL, LLC | $13 530 782 | 121 866 | 0,19% | Acciones |
| Longaeva Partners L.P. | $12 221 516 | 110 074 | 0,18% | Acciones |
| Swiss National Bank | $12 179 991 | 109 700 | 0,17% | Acciones |
| PFM Health Sciences, LP | $11 275 097 | 101 550 | 0,16% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $10 991 970 | 99 000 | 0,16% | Opción de compra |
| Aberdeen Group plc | $10 541 854 | 94 946 | 0,15% | Acciones |
| AXIOM INVESTORS LLC /DE | $9 646 286 | 86 880 | 0,14% | Acciones |
| First Light Asset Management, LLC | $9 522 488 | 85 765 | 0,14% | Acciones |
| ALGERT GLOBAL LLC | $9 263 344 | 83 431 | 0,13% | Acciones |
| Granahan Investment Management, LLC | $9 245 468 | 83 270 | 0,13% | Acciones |
| SPHERA FUNDS MANAGEMENT LTD. | $8 926 812 | 80 400 | 0,13% | Acciones |
| WCM INVESTMENT MANAGEMENT, LLC | $8 863 942 | 80 552 | 0,13% | Acciones |
| Atom Investors LP | $8 156 819 | 73 465 | 0,12% | Acciones |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $8 153 155 | 73 432 | 0,12% | Acciones |
| RHUMBLINE ADVISERS | $8 142 147 | 73 333 | 0,12% | Acciones |
| CAPITAL FUND MANAGEMENT S.A. | $7 610 884 | 68 548 | 0,11% | Acciones |
| RENAISSANCE TECHNOLOGIES LLC | $7 581 239 | 68 281 | 0,11% | Acciones |
| PICTON MAHONEY ASSET MANAGEMENT | $7 314 658 | 65 880 | 0,11% | Acciones |
| Blue Owl Capital Holdings LP | $6 823 349 | 61 455 | 0,10% | Acciones |
| ExodusPoint Capital Management, LP | $6 789 151 | 61 147 | 0,10% | Acciones |
| PRUDENTIAL FINANCIAL INC | $6 444 736 | 58 045 | 0,09% | Acciones |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $6 347 585 | 57 170 | 0,09% | Acciones |
| Trexquant Investment LP | $6 245 215 | 56 248 | 0,09% | Acciones |
| NEUBERGER BERMAN GROUP LLC | $6 210 463 | 55 935 | 0,09% | Acciones |
| CITIGROUP INC | $6 124 526 | 55 161 | 0,09% | Acciones |
| VANGUARD ASSET MANAGEMENT, Ltd | $5 915 567 | 53 279 | 0,08% | Acciones |
| WELLS FARGO & COMPANY/MN | $5 842 843 | 52 624 | 0,08% | Acciones |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $5 723 148 | 65 806 | 0,08% | Acciones |
| Nan Fung Group Holdings Ltd | $5 453 794 | 49 120 | 0,08% | Acciones |
| VOYA INVESTMENT MANAGEMENT LLC | $5 384 622 | 48 497 | 0,08% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5 362 749 | 48 300 | 0,08% | Opción de venta |
| CANADA PENSION PLAN INVESTMENT BOARD | $5 262 822 | 47 400 | 0,08% | Acciones |
| Hillsdale Investment Management Inc. | $4 885 320 | 44 000 | 0,07% | Acciones |
| Cinctive Capital Management LP | $4 745 311 | 42 739 | 0,07% | Acciones |
| Zweig-DiMenna Associates LLC | $4 674 363 | 42 100 | 0,07% | Acciones |
| TD Asset Management Inc | $4 305 521 | 38 778 | 0,06% | Acciones |
| EFG International AG | $3 726 164 | 33 563 | 0,05% | Acciones |
| FIRST TRUST ADVISORS LP | $3 606 476 | 32 482 | 0,05% | Acciones |
| Exome Asset Management LLC | $3 576 165 | 32 209 | 0,05% | Acciones |
| Rafferty Asset Management, LLC | $3 575 943 | 32 207 | 0,05% | Acciones |
| STATE OF WISCONSIN INVESTMENT BOARD | $3 573 945 | 32 189 | 0,05% | Acciones |
| MetLife Investment Management, LLC | $3 564 507 | 32 104 | 0,05% | Acciones |
| Schonfeld Strategic Advisors LLC | $3 176 234 | 28 607 | 0,05% | Acciones |
Informantes de la empresa 36 insiders · 12 directivos · 12 consejeros
| Insider | Rol | Última actividad | Acciones en propiedad | Compras 12m | Ventas 12m | Neto 12m |
|---|---|---|---|---|---|---|
| David P Meeker | President and CEO | 11 de febrero de 2026 A | 239 016 | 0 | 0 | $0 |
| Keith Michael Gottesdiener | CEO & President | 9 de marzo de 2020 M | 558 250 | 0 | 0 | $0 |
| Hunter C Smith | Chief Financial Officer | 18 de mayo de 2026 M | 119 611 | 0 | 23 | $-2 217 136 |
| Manher Joshi | Chief Medical Officer | 17 de agosto de 2026 A | — | 0 | 0 | $0 |
| Christopher Paul German | Corporate Controller & CAO | 15 de mayo de 2026 M | 0 | 0 | 2 | $-930 921 |
| Pamela J. Cramer | Chief Human Resources Officer | 11 de febrero de 2026 A | 29 376 | 0 | 4 | $-2 987 366 |
| William T. Roberts | Chief Accounting Officer | 29 de marzo de 2023 M | 7 872 | 0 | 0 | $0 |
| Linda Shapiro Manning | Chief Medical Officer | 9 de febrero de 2022 A | — | 0 | 0 | $0 |
| Murray Stewart | Chief Medical Officer | 11 de febrero de 2021 A | — | 0 | 0 | $0 |
| Nithya Desikan | Chief Commercial Officer | 31 de agosto de 2020 M | 43 602 | 0 | 0 | $0 |
| Leonardus H.T. Van Der Ploeg | Chief Scientific Officer | 31 de mayo de 2019 M | 42 339 | 0 | 0 | $0 |
| Fred T. Fiedorek | Chief Medical Officer | 14 de febrero de 2018 A | — | 0 | 0 | $0 |
| Lynn A. Tetrault | Consejero | 24 de junio de 2026 A | 11 712 | 0 | 1 | $-3 711 840 |
| Stuart A Arbuckle | Consejero | 24 de junio de 2026 A | 11 712 | 0 | 0 | $0 |
| Christophe Jean | Consejero | 24 de junio de 2026 A | 11 712 | 0 | 0 | $0 |
| Jennifer L Good | Consejero | 24 de junio de 2026 A | 11 712 | 0 | 0 | $0 |
| David W J Mcgirr | Consejero | 24 de junio de 2026 A | 11 712 | 0 | 0 | $0 |
| Kimberly J Popovits | Consejero | 1 de abril de 2026 A | — | 0 | 0 | $0 |
| Edward T. Mathers | Consejero | 12 de marzo de 2026 J | 14 168 | 0 | 0 | $0 |
| Camille L Bedrosian | Consejero | 24 de junio de 2025 A | 7 000 | 0 | 0 | $0 |
| Todd Foley | Consejero | 15 de marzo de 2021 S | 909 258 | 0 | 0 | $0 |
| Neil Exter | Consejero | 6 de junio de 2018 A | 0 | 0 | 0 | $0 |
| Hadley Harbor Master Investors (Cayman) L.P. | Propietario del 10% | 10 de octubre de 2017 C | 545 256 | 0 | 0 | $0 |
| Ravi Viswanathan | Propietario del 10% | 10 de octubre de 2017 C | 4 909 956 | 0 | 0 | $0 |
| Ipsen, S.A. | Propietario del 10% | 10 de octubre de 2017 C | 833 099 | 0 | 0 | $0 |
| Forest Baskett | Propietario del 10% | 10 de octubre de 2017 C | 4 909 956 | 0 | 0 | $0 |
| Patrick J. Kerins | Propietario del 10% | 10 de octubre de 2017 C | 4 909 956 | 0 | 0 | $0 |
| David M Mott | Propietario del 10% | 10 de octubre de 2017 C | 4 909 956 | 0 | 0 | $0 |
| James M Barrett | Propietario del 10% | 10 de octubre de 2017 C | 4 909 956 | 0 | 0 | $0 |
| Peter J Barris | Propietario del 10% | 10 de octubre de 2017 C | 4 909 956 | 0 | 0 | $0 |
| Alastair Garfield | — | 13 de agosto de 2026 S | 2 295 | 0 | 4 | $-912 697 |
| Joseph Shulman | — | 13 de agosto de 2026 M | 15 915 | 0 | 8 | $-5 858 835 |
| Jennifer Chien | — | 13 de agosto de 2026 M | 0 | 0 | 1 | $-8 901 395 |
| Yann Mazabraud | — | 12 de agosto de 2026 M | 55 655 | 0 | 6 | $-6 620 591 |
| Simon Kelner | — | 11 de febrero de 2021 A | — | 0 | 0 | $0 |
| Scott D. Sandell | — | 10 de octubre de 2017 C | 4 909 956 | 0 | 0 | $0 |
Informantes de las presentaciones SEC Form 3/4/5; neto = solo P/S de mercado abierto
Activistas y propietarios del %+ 5 7 tenencias
Inversores que presentaron el Anexo 13D de la SEC — propiedad beneficiosa superior al % 5 con la intención de influir en el emisor (participaciones activistas, campañas de la junta directiva, M&A). Cada fila muestra el estado conocido más reciente de la posición de ese declarante.
| Declarante | Presentado | Participación | Estado | Propósito | Presentación |
|---|---|---|---|---|---|
| 30 de abril de 2024 | — | Presentación inicial | — | SEC | |
| Perceptive Advisors LLC, Perceptive Life Sciences Master Fund, Ltd., C2 Life Sciences LLC, Perceptive Discovery Fund LP, Joseph Edelman ×3 presentaciones | 17 de abril de 2024 | — | Presentación inicial | — | SEC |
| New Enterprise Associates 13, L.P., NEA Partners 13, L.P., NEA 13 GP, LTD, Forest Baskett, Patrick J. Kerins, Scott D. Sandell ×2 presentaciones | 29 de marzo de 2023 | — | Presentación inicial | Inversión pasiva | SEC |
| MPM BioVentures V, L.P., MPM Asset Management Investors BV5 LLC, MPM BioVentures V GP LLC, MPM BioVentures V LLC, Ansbert Gadicke, Luke Evnin, Todd Foley ×2 presentaciones | 26 de junio de 2020 | — | Presentación inicial | — | SEC |
| Persona informante no revelada, Persona informante no revelada, Persona informante no revelada, Persona informante no revelada, Persona informante no revelada | 5 de febrero de 2020 | — | Presentación inicial | — | SEC |
| Persona informante no revelada, Persona informante no revelada, Persona informante no revelada, Persona informante no revelada | 12 de febrero de 2019 | — | Presentación inicial | Inversión pasiva | SEC |
| OrbiMed Advisors LLC, OrbiMed Capital GP V LLC ×5 presentaciones | 10 de agosto de 2018 | — | Presentación inicial | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Propiedad de ETFs Mantenido por 52 ETFs
El peso refleja solo las tenencias directas de acciones (N-PORT); los fondos apalancados o basados en derivados pueden tener exposición adicional a swaps no mostrada.
| Fondo | Ponderación | Unidades | A fecha de | Fuente |
|---|---|---|---|---|
| MEDI · Harbor ETF Trust | 3,79% | 12 831 NS | 30 de abril de 2026 | N-PORT |
| HAPS · Harbor ETF Trust | 1,58% | 30 540 NS | 30 de abril de 2026 | N-PORT |
| BBP · ETFis Series Trust I | 1,14% | 8 333 NS | 30 de abril de 2026 | N-PORT |
| GURU · Global X Funds | 0,88% | 6 307 NS | 30 de abril de 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0,85% | 53 930 NS | 30 de abril de 2026 | N-PORT |
| GDOC · Goldman Sachs ETF Trust | 0,68% | 1 538 NS | 31 de mayo de 2026 | N-PORT |
| IBB · iShares Trust | 0,56% | 492 552 SH | 19 de agosto de 2026 | Diario |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,52% | 3 798 SH | 19 de agosto de 2026 | Diario |
| GSC · Goldman Sachs ETF Trust | 0,51% | 14 505 NS | 31 de mayo de 2026 | N-PORT |
| IWO · iShares Trust | 0,39% | 502 139 SH | 19 de agosto de 2026 | Diario |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0,36% | 59 038 SH | 19 de agosto de 2026 | Diario |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,36% | 30 730 NS | 31 de mayo de 2026 | N-PORT |
| BIB · ProShares Trust | 0,30% | 2 526 NS | 31 de mayo de 2026 | N-PORT |
| FSCC · Federated Hermes ETF Trust | 0,30% | 9 299 NS | 31 de mayo de 2026 | N-PORT |
| FNY · First Trust Exchange-Traded AlphaDE… | 0,25% | 15 768 NS | 30 de abril de 2026 | N-PORT |
| BKSE · BNY Mellon ETF Trust | 0,24% | 2 335 NS | 30 de abril de 2026 | N-PORT |
| BBSC · J.P. Morgan Exchange-Traded Fund Tr… | 0,22% | 20 187 NS | 30 de abril de 2026 | N-PORT |
| VBK · VANGUARD INDEX FUNDS | 0,21% | 908 106 SH | 19 de agosto de 2026 | Diario |
| IWM · iShares Trust | 0,20% | 1 409 592 SH | 19 de agosto de 2026 | Diario |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0,19% | 317 548 SH | 19 de agosto de 2026 | Diario |
| ISCG · iShares Trust | 0,19% | 16 599 SH | 19 de agosto de 2026 | Diario |
| FFSM · FIDELITY COVINGTON TRUST | 0,16% | 25 413 NS | 30 de abril de 2026 | N-PORT |
| RSSL · Global X Funds | 0,13% | 22 978 NS | 30 de abril de 2026 | N-PORT |
| ITWO · ProShares Trust | 0,12% | 2 491 NS | 31 de mayo de 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,11% | 292 435 NS | 31 de mayo de 2026 | N-PORT |
| ISCB · iShares Trust | 0,09% | 2 368 SH | 19 de agosto de 2026 | Diario |
| VB · VANGUARD INDEX FUNDS | 0,09% | 1 571 929 SH | 19 de agosto de 2026 | Diario |
| VHT · VANGUARD WORLD FUND | 0,09% | 164 403 SH | 19 de agosto de 2026 | Diario |
| VXF · VANGUARD INDEX FUNDS | 0,08% | 715 506 SH | 19 de agosto de 2026 | Diario |
| FHLC · FIDELITY COVINGTON TRUST | 0,07% | 26 169 NS | 30 de abril de 2026 | N-PORT |
| FAD · First Trust Exchange-Traded AlphaDE… | 0,07% | 4 339 NS | 30 de abril de 2026 | N-PORT |
| UWM · ProShares Trust | 0,07% | 1 948 NS | 31 de mayo de 2026 | N-PORT |
| ESML · iShares Trust | 0,07% | 17 397 SH | 19 de agosto de 2026 | Diario |
| GSSC · Goldman Sachs ETF Trust | 0,06% | 7 134 NS | 31 de mayo de 2026 | N-PORT |
| FNX · First Trust Exchange-Traded AlphaDE… | 0,06% | 10 436 NS | 30 de abril de 2026 | N-PORT |
| WSML · iShares Trust | 0,06% | 3 421 SH | 19 de agosto de 2026 | Diario |
| URTY · ProShares Trust | 0,05% | 1 974 NS | 31 de mayo de 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0,05% | 12 143 SH | 19 de agosto de 2026 | Diario |
| HDG · ProShares Trust | 0,02% | 49 NS | 31 de mayo de 2026 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0,01% | 16 766 NS | 31 de mayo de 2026 | N-PORT |
| TILT · FlexShares Trust | 0,01% | 2 916 NS | 30 de abril de 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0,01% | 2 177 236 SH | 19 de agosto de 2026 | Diario |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0,01% | 4 502 SH | 19 de agosto de 2026 | Diario |
| ITOT · iShares Trust | 0,01% | 84 094 SH | 19 de agosto de 2026 | Diario |
| ESGV · VANGUARD WORLD FUND | 0,01% | 12 173 SH | 19 de agosto de 2026 | Diario |
| IWV · iShares Trust | 0,01% | 14 092 SH | 19 de agosto de 2026 | Diario |
| SCHK · SCHWAB STRATEGIC TRUST | 0,01% | 4 991 NS | 31 de mayo de 2026 | N-PORT |
| SCHB · SCHWAB STRATEGIC TRUST | 0,01% | 35 572 NS | 31 de mayo de 2026 | N-PORT |
| AVUQ · AMERICAN CENTURY ETF TRUST | 0,00% | 24 NS | 31 de mayo de 2026 | N-PORT |
| VT · VANGUARD INTERNATIONAL EQUITY INDEX… | 0,00% | 43 280 SH | 19 de agosto de 2026 | Diario |