AKTS — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| MPM BIOIMPACT LLC | $155 860 155 | 4 835 872 | 15,71% | Actions |
| EcoR1 Capital, LLC | $155 492 636 | 4 824 469 | 15,67% | Actions |
| Blue Owl Capital Holdings LP | $98 953 158 | 3 070 219 | 9,97% | Actions |
| BlackRock, Inc. | $73 431 479 | 2 278 358 | 7,40% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $63 372 044 | 1 966 244 | 6,39% | Actions |
| RTW INVESTMENTS, LP | $51 311 546 | 1 592 043 | 5,17% | Actions |
| RA CAPITAL MANAGEMENT, L.P. | $42 363 273 | 1 314 405 | 4,27% | Actions |
| BAKER BROS. ADVISORS LP | $32 112 393 | 996 351 | 3,24% | Actions |
| Octagon Capital Advisors LP | $30 968 099 | 960 847 | 3,12% | Actions |
| Merck & Co., Inc. | $30 710 162 | 952 844 | 3,09% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $26 334 327 | 817 075 | 2,65% | Actions |
| JANUS HENDERSON GROUP PLC | $26 022 437 | 1 454 267 | 2,62% | Actions |
| TCG Crossover Management, LLC | $22 450 129 | 696 560 | 2,26% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $16 787 478 | 520 737 | 1,69% | Actions |
| EVENTIDE ASSET MANAGEMENT, LLC | $16 340 610 | 507 000 | 1,65% | Actions |
| Avidity Partners Management LP | $15 605 766 | 484 200 | 1,57% | Actions |
| STATE STREET CORP | $15 599 642 | 484 010 | 1,57% | Actions |
| a16z Capital Management, L.L.C. | $13 375 450 | 415 000 | 1,35% | Actions |
| Alyeska Investment Group, L.P. | $9 346 700 | 290 000 | 0,94% | Actions |
| FMR LLC | $9 205 887 | 285 631 | 0,93% | Actions |
| ArrowMark Colorado Holdings LLC | $7 924 455 | 245 872 | 0,80% | Actions |
| NORTHERN TRUST CORP | $5 819 933 | 180 575 | 0,59% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $5 377 318 | 166 842 | 0,54% | Actions |
| BARCLAYS PLC | $4 889 163 | 151 696 | 0,49% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4 680 441 | 145 220 | 0,47% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $4 313 470 | 133 834 | 0,43% | Actions |
| TD Asset Management Inc | $3 413 221 | 105 902 | 0,34% | Actions |
| SOROS FUND MANAGEMENT LLC | $3 223 000 | 100 000 | 0,32% | Actions |
| Woodline Partners LP | $3 223 000 | 100 000 | 0,32% | Actions |
| UBS Group AG | $3 221 711 | 99 960 | 0,32% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $3 074 742 | 95 400 | 0,31% | Actions |
| BANK OF AMERICA CORP /DE/ | $2 347 472 | 72 835 | 0,24% | Actions |
| POLEN CAPITAL MANAGEMENT LLC | $2 047 056 | 63 514 | 0,21% | Actions |
| MORGAN STANLEY | $2 018 758 | 62 636 | 0,20% | Actions |
| RAYMOND JAMES FINANCIAL INC | $1 626 455 | 50 464 | 0,16% | Actions |
| Nuveen, LLC | $1 605 569 | 49 816 | 0,16% | Actions |
| Bank of New York Mellon Corp | $1 587 324 | 49 250 | 0,16% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $1 551 005 | 48 123 | 0,16% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1 548 458 | 48 044 | 0,16% | Actions |
| Quantinno Capital Management LP | $1 511 168 | 46 887 | 0,15% | Actions |
| GREAT LAKES ADVISORS, LLC | $1 405 615 | 43 612 | 0,14% | Actions |
| Mirador Capital Partners LP | $1 293 197 | 40 124 | 0,13% | Actions |
| Squarepoint Ops LLC | $1 237 020 | 38 381 | 0,12% | Actions |
| Jump Financial, LLC | $1 056 467 | 32 779 | 0,11% | Actions |
| Sofinnova Investments, Inc. | $1 045 412 | 32 436 | 0,11% | Actions |
| TWO SIGMA INVESTMENTS, LP | $996 358 | 30 914 | 0,10% | Actions |
| READYSTATE ASSET MANAGEMENT LP | $966 900 | 30 000 | 0,10% | Actions |
| WELLS FARGO & COMPANY/MN | $891 450 | 27 659 | 0,09% | Actions |
| RHUMBLINE ADVISERS | $868 429 | 26 945 | 0,09% | Actions |
| CITADEL ADVISORS LLC | $823 058 | 25 537 | 0,08% | Actions |
| SEVEN GRAND MANAGERS, LLC | $805 750 | 25 000 | 0,08% | Actions |
| Ghisallo Capital Management LLC | $805 750 | 25 000 | 0,08% | Actions |
| TUDOR INVESTMENT CORP ET AL | $689 786 | 21 402 | 0,07% | Actions |
| GOLDMAN SACHS GROUP INC | $685 790 | 21 278 | 0,07% | Actions |
| DEUTSCHE BANK AG\ | $677 539 | 21 022 | 0,07% | Actions |
| AMERIPRISE FINANCIAL INC | $644 600 | 20 000 | 0,06% | Actions |
| Mariner, LLC | $572 697 | 17 770 | 0,06% | Actions |
| SEI INVESTMENTS CO | $528 515 | 16 402 | 0,05% | Actions |
| Virtus Investment Advisers, LLC | $480 872 | 14 920 | 0,05% | Actions |
| Invesco Ltd. | $480 485 | 14 908 | 0,05% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $463 435 | 14 379 | 0,05% | Actions |
| CITIGROUP INC | $424 695 | 13 177 | 0,04% | Actions |
| MetLife Investment Management, LLC | $418 797 | 12 994 | 0,04% | Actions |
| Caprock Group, LLC | $319 335 | 9 908 | 0,03% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $314 855 | 9 769 | 0,03% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $277 919 | 8 623 | 0,03% | Actions |
| JPMORGAN CHASE & CO | $266 021 | 8 835 | 0,03% | Actions |
| Russell Investments Group, Ltd. | $249 911 | 7 754 | 0,03% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $241 725 | 7 500 | 0,02% | Actions |
| AXQ CAPITAL, LP | $226 255 | 7 020 | 0,02% | Actions |
| Vanguard Global Advisers, LLC | $221 936 | 6 886 | 0,02% | Actions |
| PNC Financial Services Group, Inc. | $197 893 | 6 140 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $178 232 | 5 530 | 0,02% | Actions |
| LANARK FINANCIAL, INC. | $172 688 | 5 358 | 0,02% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $105 714 | 3 280 | 0,01% | Actions |
| STRS OHIO | $99 913 | 3 100 | 0,01% | Actions |
| Tower Research Capital LLC (TRC) | $73 098 | 2 268 | 0,01% | Actions |
| Pinnacle Wealth Planning Services, Inc. | $73 065 | 2 267 | 0,01% | Actions |
| Legal & General Group Plc | $66 623 | 2 062 | 0,01% | Actions |
| T. Rowe Price Investment Management, Inc. | $66 119 | 2 051 447 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $62 043 | 1 925 | 0,01% | Actions |
| SALEM INVESTMENT COUNSELORS INC | $32 230 | 1 000 | 0,00% | Actions |
| State of Wyoming | $31 747 | 985 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $25 000 | 797 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $24 608 | 763 499 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $22 589 | 700 | 0,00% | Actions |
| FIFTH THIRD BANCORP | $18 576 | 576 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $12 795 | 397 | 0,00% | Actions |
| Global Retirement Partners, LLC | $12 731 | 395 | 0,00% | Actions |
| Arax Advisory Partners | $12 408 | 385 | 0,00% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $9 282 | 288 | 0,00% | Actions |
| Federation des caisses Desjardins du Quebec | $8 057 | 250 | 0,00% | Actions |
| Versant Capital Management, Inc | $6 308 | 324 | 0,00% | Actions |
| Sterling Capital Management LLC | $5 930 | 184 | 0,00% | Actions |
| Allworth Financial LP | $3 997 | 124 | 0,00% | Actions |
| IFP Advisors, Inc | $3 255 | 101 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $2 578 | 80 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $2 414 | 77 | 0,00% | Actions |
| HM PAYSON & CO | $2 386 | 74 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $1 257 | 39 | 0,00% | Actions |
| Quarry LP | $1 096 | 34 | 0,00% | Actions |
| SJS Investment Consulting Inc. | $1 064 | 33 | 0,00% | Actions |
| CoreCap Advisors, LLC | $935 | 29 | 0,00% | Actions |
| WPG Advisers, LLC | $806 | 25 | 0,00% | Actions |
| FWL INVESTMENT MANAGEMENT, LLC | $741 | 23 | 0,00% | Actions |
| GAMMA Investing LLC | $645 | 20 | 0,00% | Actions |
| Rossby Financial, LCC | $580 | 18 | 0,00% | Actions |
| CWM, LLC | $376 | 21 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $258 | 8 | 0,00% | Actions |
| Clearstead Advisors, LLC | $195 | 6 | 0,00% | Actions |
| Essential Partners LLC | $129 | 4 | 0,00% | Actions |
| SG Americas Securities, LLC | $109 | 3 368 | 0,00% | Actions |
| Freestone Grove Partners LP | $64 | 2 | 0,00% | Actions |
| Covestor Ltd | $1 | 23 | 0,00% | Actions |