DRUG — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | $93 518 052 | 1 284 324 | 14,26% | Actions |
| Cormorant Asset Management, LP | $63 180 000 | 900 000 | 9,63% | Actions |
| BlackRock, Inc. | $48 170 117 | 686 184 | 7,34% | Actions |
| Vivo Capital, LLC | $39 113 474 | 557 172 | 5,96% | Actions |
| Vestal Point Capital, LP | $38 259 000 | 545 000 | 5,83% | Actions |
| BRAIDWELL LP | $33 964 304 | 483 822 | 5,18% | Actions |
| Driehaus Capital Management LLC | $30 423 065 | 433 377 | 4,64% | Actions |
| Balyasny Asset Management L.P. | $24 222 721 | 345 053 | 3,69% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $23 517 000 | 335 000 | 3,59% | Actions |
| Point72 Asset Management, L.P. | $22 984 603 | 327 416 | 3,50% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $19 866 600 | 283 000 | 3,03% | Actions |
| RA CAPITAL MANAGEMENT, L.P. | $18 603 000 | 265 000 | 2,84% | Actions |
| Parkman Healthcare Partners LLC | $14 394 721 | 205 053 | 2,19% | Actions |
| MPM BIOIMPACT LLC | $14 188 403 | 202 114 | 2,16% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $12 026 312 | 171 315 | 1,83% | Actions |
| GOLDMAN SACHS GROUP INC | $9 384 968 | 133 689 | 1,43% | Actions |
| EVENTIDE ASSET MANAGEMENT, LLC | $9 126 913 | 130 013 | 1,39% | Actions |
| STATE STREET CORP | $8 576 896 | 122 178 | 1,31% | Actions |
| SEVEN GRAND MANAGERS, LLC | $8 424 000 | 120 000 | 1,28% | Actions |
| GREAT POINT PARTNERS LLC | $7 694 131 | 109 603 | 1,17% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $7 311 049 | 104 146 | 1,11% | Actions |
| ORBIMED ADVISORS LLC | $6 528 600 | 93 000 | 1,00% | Actions |
| ACUTA CAPITAL PARTNERS, LLC | $6 510 699 | 92 745 | 0,99% | Actions |
| Ikarian Capital, LLC | $6 244 361 | 88 951 | 0,95% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $5 620 212 | 80 060 | 0,86% | Actions |
| Sio Capital Management, LLC | $5 191 430 | 73 952 | 0,79% | Actions |
| Trexquant Investment LP | $4 957 173 | 70 615 | 0,76% | Actions |
| B Group, Inc. | $4 738 500 | 67 500 | 0,72% | Actions |
| MILLENNIUM MANAGEMENT LLC | $4 685 148 | 66 740 | 0,71% | Actions |
| CITADEL ADVISORS LLC | $4 670 616 | 66 533 | 0,71% | Actions |
| Schonfeld Strategic Advisors LLC | $4 652 645 | 66 277 | 0,71% | Actions |
| Walleye Capital LLC | $4 640 641 | 66 106 | 0,71% | Actions |
| VANGUARD GROUP INC | $3 790 871 | 48 576 | 0,58% | Actions |
| Woodline Partners LP | $3 205 894 | 45 668 | 0,49% | Actions |
| NORTHERN TRUST CORP | $2 981 114 | 42 466 | 0,45% | Actions |
| Artia Global Partners LP | $2 696 171 | 38 407 | 0,41% | Actions |
| AMERIPRISE FINANCIAL INC | $2 660 720 | 37 902 | 0,41% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $2 509 440 | 35 747 | 0,38% | Actions |
| KVP Capital Advisors, LP | $2 233 273 | 31 813 | 0,34% | Actions |
| SUPERSTRING CAPITAL MANAGEMENT LP | $2 138 011 | 30 456 | 0,33% | Actions |
| ADAR1 Capital Management, LLC | $2 127 060 | 30 300 | 0,32% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $1 956 474 | 27 870 | 0,30% | Actions |
| BANK OF AMERICA CORP /DE/ | $1 893 013 | 26 966 | 0,29% | Actions |
| AdvisorShares Investments LLC | $1 704 035 | 24 274 | 0,26% | Actions |
| Aquatic Capital Management LLC | $1 462 336 | 20 831 | 0,22% | Actions |
| PLATINUM INVESTMENT MANAGEMENT LTD | $1 342 715 | 19 127 | 0,20% | Actions |
| MORGAN STANLEY | $1 305 698 | 18 599 | 0,20% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1 265 846 | 18 032 | 0,19% | Actions |
| Nuveen, LLC | $1 185 608 | 16 889 | 0,18% | Actions |
| UBS Group AG | $1 090 627 | 15 536 | 0,17% | Actions |
| Bank of New York Mellon Corp | $1 046 100 | 14 902 | 0,16% | Actions |
| Exome Asset Management LLC | $709 722 | 10 110 | 0,11% | Actions |
| TWO SIGMA INVESTMENTS, LP | $674 341 | 9 606 | 0,10% | Actions |
| RHUMBLINE ADVISERS | $613 051 | 8 733 | 0,09% | Actions |
| TUDOR INVESTMENT CORP ET AL | $582 028 | 8 291 | 0,09% | Actions |
| FRANKLIN RESOURCES INC | $563 004 | 8 020 | 0,09% | Actions |
| FMR LLC | $551 159 | 7 851 | 0,08% | Actions |
| DEUTSCHE BANK AG\ | $548 122 | 7 808 | 0,08% | Actions |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $505 370 | 7 199 | 0,08% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $491 470 | 7 001 | 0,07% | Actions |
| LPL Financial LLC | $484 029 | 6 895 | 0,07% | Actions |
| WELLS FARGO & COMPANY/MN | $474 622 | 6 761 | 0,07% | Actions |
| JANE STREET GROUP, LLC | $449 280 | 6 400 | 0,07% | Actions |
| Seven Fleet Capital Management LP | $448 929 | 6 395 | 0,07% | Actions |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $427 588 | 6 091 | 0,07% | Actions |
| ALLIANCEBERNSTEIN L.P. | $414 470 | 5 680 | 0,06% | Actions |
| Engineers Gate Manager LP | $379 922 | 5 412 | 0,06% | Actions |
| DNB Asset Management AS | $338 504 | 4 822 | 0,05% | Actions |
| JPMORGAN CHASE & CO | $330 542 | 4 778 | 0,05% | Actions |
| MetLife Investment Management, LLC | $316 672 | 4 511 | 0,05% | Actions |
| Invesco Ltd. | $281 923 | 4 016 | 0,04% | Actions |
| Vanguard Global Advisers, LLC | $271 674 | 3 870 | 0,04% | Actions |
| CITIGROUP INC | $259 682 | 3 612 | 0,04% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $239 522 | 3 412 | 0,04% | Actions |
| STRS OHIO | $231 660 | 3 300 | 0,04% | Actions |
| BARCLAYS PLC | $228 571 | 3 256 | 0,03% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $182 520 | 2 600 | 0,03% | Actions |
| Russell Investments Group, Ltd. | $179 220 | 2 553 | 0,03% | Actions |
| Police & Firemen's Retirement System of New Jersey | $142 927 | 2 036 | 0,02% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $86 627 | 1 234 | 0,01% | Actions |
| Caitong International Asset Management Co., Ltd | $84 310 | 1 201 | 0,01% | Actions |
| ROYAL BANK OF CANADA | $80 000 | 1 133 | 0,01% | Actions |
| Tower Research Capital LLC (TRC) | $70 972 | 1 011 | 0,01% | Actions |
| Legal & General Group Plc | $50 465 | 718 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $47 174 | 672 | 0,01% | Actions |
| China Universal Asset Management Co., Ltd. | $42 120 | 600 | 0,01% | Actions |
| State of Wyoming | $33 626 | 479 | 0,01% | Actions |
| Pinnacle Wealth Planning Services, Inc. | $9 688 | 138 | 0,00% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $6 880 | 98 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $5 616 | 80 | 0,00% | Actions |
| Allworth Financial LP | $3 370 | 48 | 0,00% | Actions |
| Quarry LP | $1 895 | 27 | 0,00% | Actions |
| Sterling Capital Management LLC | $1 825 | 26 | 0,00% | Actions |
| GAMMA Investing LLC | $1 404 | 20 | 0,00% | Actions |
| TD Waterhouse Canada Inc. | $1 331 | 20 | 0,00% | Actions |
| CWM, LLC | $803 | 11 | 0,00% | Actions |
| Arax Advisory Partners | $772 | 11 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $433 | 6 167 | 0,00% | Actions |
| Bell Investment Advisors, Inc | $422 | 6 | 0,00% | Actions |
| SJS Investment Consulting Inc. | $351 | 5 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $351 | 5 | 0,00% | Actions |