QTTB — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| ORBIMED ADVISORS LLC | $52 590 554 | 4 127 987 | 18,53% | Actions |
| Boxer Capital Management, LLC | $40 122 209 | 3 149 310 | 14,14% | Actions |
| Atlas Venture Life Science Advisors, LLC | $34 615 930 | 2 717 106 | 12,20% | Actions |
| BVF INC/IL | $29 939 000 | 2 350 000 | 10,55% | Actions |
| RA CAPITAL MANAGEMENT, L.P. | $29 715 502 | 2 332 457 | 10,47% | Actions |
| Point72 Asset Management, L.P. | $14 949 065 | 1 173 396 | 5,27% | Actions |
| Opaleye Management Inc. | $11 860 940 | 931 000 | 4,18% | Actions |
| Logos Global Management LP | $10 192 000 | 800 000 | 3,59% | Actions |
| SummitTX Capital, L.P. | $9 348 281 | 733 774 | 3,29% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $6 609 550 | 518 803 | 2,33% | Actions |
| Ikarian Capital, LLC | $5 478 200 | 430 000 | 1,93% | Actions |
| Woodline Partners LP | $3 646 341 | 286 212 | 1,29% | Actions |
| AMERICAN CENTURY COMPANIES INC | $3 474 860 | 272 752 | 1,22% | Actions |
| Sanofi | $3 109 617 | 244 083 | 1,10% | Actions |
| ACORN CAPITAL ADVISORS, LLC | $2 754 019 | 216 171 | 0,97% | Actions |
| Ikarian Capital, LLC | $2 548 000 | 200 000 | 0,90% | Option de vente |
| RENAISSANCE TECHNOLOGIES LLC | $2 288 104 | 179 600 | 0,81% | Actions |
| JANE STREET GROUP, LLC | $2 073 396 | 162 747 | 0,73% | Actions |
| MONIMUS CAPITAL MANAGEMENT, LP | $1 682 139 | 132 036 | 0,59% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $1 661 640 | 130 427 | 0,59% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $1 563 506 | 122 690 | 0,55% | Actions |
| CITADEL ADVISORS LLC | $1 537 247 | 120 663 | 0,54% | Actions |
| BlackRock, Inc. | $1 509 780 | 118 507 | 0,53% | Actions |
| VANGUARD GROUP INC | $1 065 889 | 321 051 | 0,38% | Actions |
| MARSHALL WACE, LLP | $854 153 | 67 045 | 0,30% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $843 605 | 66 217 | 0,30% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $780 962 | 61 300 | 0,28% | Option de vente |
| Carlyle Group Inc. | $769 020 | 60 363 | 0,27% | Actions |
| STATE STREET CORP | $665 206 | 52 214 | 0,23% | Actions |
| TWO SIGMA INVESTMENTS, LP | $631 675 | 49 582 | 0,22% | Actions |
| Quadrature Capital Ltd | $463 685 | 36 396 | 0,16% | Actions |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $440 970 | 34 613 | 0,16% | Actions |
| DAFNA Capital Management LLC | $419 095 | 32 896 | 0,15% | Actions |
| Knott David M Jr | $387 449 | 30 412 | 0,14% | Actions |
| Affinity Asset Advisors, LLC | $353 879 | 27 777 | 0,12% | Actions |
| Squarepoint Ops LLC | $303 085 | 23 790 | 0,11% | Actions |
| NORTHERN TRUST CORP | $301 059 | 23 631 | 0,11% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $300 511 | 23 588 | 0,11% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $297 377 | 23 342 | 0,10% | Actions |
| MANGROVE PARTNERS IM, LLC | $282 191 | 22 150 | 0,10% | Actions |
| LPL Financial LLC | $231 486 | 18 170 | 0,08% | Actions |
| UBS Group AG | $191 202 | 15 008 | 0,07% | Actions |
| Balyasny Asset Management L.P. | $157 237 | 12 342 | 0,06% | Actions |
| ExodusPoint Capital Management, LP | $144 421 | 11 336 | 0,05% | Actions |
| MILLENNIUM MANAGEMENT LLC | $139 223 | 10 928 | 0,05% | Actions |
| XTX Topco Ltd | $138 535 | 10 874 | 0,05% | Actions |
| MORGAN STANLEY | $82 259 | 6 456 | 0,03% | Actions |
| Vanguard Global Advisers, LLC | $61 458 | 4 824 | 0,02% | Actions |
| FMR LLC | $43 163 | 3 388 | 0,02% | Actions |
| CITIGROUP INC | $36 793 | 2 888 | 0,01% | Actions |
| Private Wealth Asset Management, LLC | $21 658 | 1 700 | 0,01% | Actions |
| Arax Advisory Partners | $14 154 | 1 111 | 0,00% | Actions |
| FEDERATED HERMES, INC. | $13 377 | 1 050 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $7 351 | 577 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $6 585 | 500 | 0,00% | Actions |
| Russell Investments Group, Ltd. | $5 784 | 454 | 0,00% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $3 860 | 303 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $3 058 | 240 | 0,00% | Actions |
| ACADIAN ASSET MANAGEMENT LLC | $2 779 | 218 234 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $2 115 | 166 | 0,00% | Actions |
| Truvestments Capital LLC | $2 064 | 162 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $1 579 | 124 | 0,00% | Actions |
| Allworth Financial LP | $1 376 | 108 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $1 198 | 94 | 0,00% | Actions |
| Federation des caisses Desjardins du Quebec | $888 | 70 | 0,00% | Actions |
| Clearstead Advisors, LLC | $854 | 67 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $573 | 45 | 0,00% | Actions |
| GROUP ONE TRADING LLC | $433 | 34 | 0,00% | Actions |
| CWM, LLC | $250 | 39 | 0,00% | Actions |
| Cambridge Investment Research Advisors, Inc. | $230 | 18 081 | 0,00% | Actions |
| HRT FINANCIAL LP | $203 | 15 949 | 0,00% | Actions |
| HARBOUR INVESTMENTS, INC. | $140 | 11 | 0,00% | Actions |
| AdvisorNet Financial, Inc | $25 | 2 | 0,00% | Actions |
| DANSKE BANK A/S | $13 | 1 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $0 | 43 | 0,00% | Actions |