CRNX Crinetics Pharmaceuticals, Inc. - Common Stock

NASDAQ · Pharmaceuticals · Lihat di SEC EDGAR ↗
$84,77
Harga · Agu 19, 2026
Fundamental per Agu 3, 2026

Tentang Crinetics Pharmaceuticals, Inc. - Common Stock Tinjauan perusahaan dari Wikipedia

Crinetics Pharmaceuticals is a global pharmaceutical company known for developing drugs for the treatment of endocrine-related diseases. It was founded by Scott Struthers, Frank Zhu, Ana Kusnetzow, and Stephen F. Betz in 2008 and is headquartered in San Diego, California. It went public on NASDAQ in 2018.

Baca selengkapnya

Crinetics Pharmaceuticals is a global pharmaceutical company known for developing drugs for the treatment of endocrine-related diseases. It was founded by Scott Struthers, Frank Zhu, Ana Kusnetzow, and Stephen F. Betz in 2008 and is headquartered in San Diego, California. It went public on NASDAQ in 2018.

In July 2026, Vertex Pharmaceuticals agreed to acquire the company for $10 billion.

History

Struthers, Zhu, Kusnetzow, and Betz founded Crinetics in 2008 after previously working together on a small molecule drug for the treatment of endometriosis at Neurocrine Biosciences.

Crinetics expanded into a larger laboratory in 2010. After receiving NIH grant funding, Crinetics moved into its second laboratory.

In 2011, Crinetics Pharmaceuticals competed for the Michelson Prize, a competition sponsored by the Found Animals Foundation to develop a low-cost, non-surgical method for sterilizing dogs and cats, which would later lead to the licensing of a molecule for the treatment of acromegaly in large breed dogs.

Crinetics first synthesized its lead drug candidate to treat acromegaly. The drug was named paltusotine, in 2016. Crinetics Pharmaceuticals went public with an IPO in 2018. It conducted Phase II trials for paltusotine from 2019 to 2020. It conducted Phase III trials for paltusotine from 2021 to 2024. After the drug succeeded in a second Phase III study, the FDA accepted the company's new drug application for paltusotine and the company announced it was planning for a 2025 launch for the drug. The FDA set a Prescription Drug User Fee Act for the drug on September 25, 2025.

In 2021, Crinetics, together with 5AM Ventures and Frazier Healthcare Partners, formed an independently operated new company, Radionetics Oncology, aimed to develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range of oncology indications.

Crinetics partnered with the veterinary medicine company Loyal to develop a pill to extend the lifespans of large dogs in 2023.

In 2024, Scott Struthers received the Ernst & Young Entrepreneur of the Year Award for his work with Crinetics. In 2024, Crinetics was reported to have patent activity in rare diseases, health technology, and addiction therapies.

In 2024, Radionetics formed a strategic relationship with Eli Lilly and Company to take forward Radionetics’ proprietary GPCR targeting small molecule radiopharmaceuticals. Under the terms of the agreement, Radionetics received a $140 million upfront cash payment. As part of the strategic agreement, Lilly obtained the exclusive right to acquire Radionetics upon conclusion of an exercise period for $1 billion.

Crinetics also established its first office outside the United States in Zug, Switzerland in 2024.

In 2025, Crinetics Pharmaceuticals plans to file an Investigational New Drug for an oral thyroid stimulating hormone receptor antagonist and its nonpeptide drug conjugate (CRN09682). A total of four development candidates are currently in IND-enabling studies, including a PTH antagonist (Hyperparathyrodism), non-peptide drug conjugate (NETs and SST2-expressing solid tumors), TSH antagonist (Graves’ disease & TED) and SST3 agonist (ADPKD).

In July 2026, Vertex Pharmaceuticals agreed to acquire Crinetics for $10 billion.

Treatments

Crinetics’ pipeline focuses on synthesizing novel molecules for rare endocrine diseases. It is most known for developing paltusotine, a drug designed to treat the hormonal disorder acromegaly. Paltusotine works by helping moderate elevated IGF-1 levels, which is the main symptom of acromegaly. Paltusotine has also been tested as a treatment for carcinoid syndrome.

Crinetics has also developed oral treatments for neuroendocrine tumors, hyperinsulism, and Cushing's disease. The company's drug for treating Cushing's disease, Atumeltnant (also known as CRN049894), works by reducing levels of ACTH.

The company's pipeline also includes an oral parathyroid hormone inhibitor program for hyperparathyroidism and treatments for thyroid eye disease, Graves' disease, and obesity. Additionally, Crinetics nonpeptide drug conjugates (NDCs) include CRN09682, which is a somatostatin receptor 2 (SST2) targeted drug. NDCs are a new technology developed in-house by Crinetics.

== References ==

Sumber: Wikipedia (English), CC BY-SA 4.0 · Lihat di Wikipedia ↗

Wikidata ↗

CRNX Cuplikan Saham Harga, kapitalisasi pasar, P/E, EPS, ROE, utang/ekuitas, kisaran 52 minggu

Harga
$84.77
Kapitalisasi Pasar
$8.10B
P/E (TTM)
-17.1
EPS (TTM)
$-4.95
Pendapatan (TTM)
$8M
Imbal Hasil Dividen
ROE
-43.0%
D/E Utang/Ekuitas
Rentang 52M
$29 – $85

CRNX Grafik Harga Saham OHLCV harian dengan indikator teknis — geser, perbesar, dan sesuaikan tampilan Anda

Kinerja 10 Tahun Tren Pendapatan, laba bersih, margin, dan EPS

Pendapatan & Laba Bersih $8M
10-point trend, +1206.6%
2016-12-31 2025-12-31
EPS $-4.95
6-point trend, -104.5%
2020-12-31 2025-12-31
Arus Kas Bebas $-384M
8-point trend, -1770.0%
2018-12-31 2025-12-31
Margin -6046.2%

Valuasi Rasio P/E, P/S, P/B, EV/EBITDA — apakah sahamnya mahal atau murah?

Metrik
Tren 5 Tahun
CRNX
Median Rekan
P/E (TTM)
5-point trend, +7.3%
-17.1
47.9
P/S (TTM)
5-point trend, -53.9%
1052.7
16.2
P/B
5-point trend, +10.1%
8.2
9.3
Price / FCF (Harga / FCF)
5-point trend, +23.7%
-21.1

Profitabilitas Margin kotor, operasional, dan bersih; ROE, ROA, ROIC

Metrik
Tren 5 Tahun
CRNX
Median Rekan
Operating Margin (Margin Operasi)
5-point trend, +32.8%
-6714.8%
Net Profit Margin (Margin Laba Bersih)
5-point trend, +39.4%
-6046.2%
5.1%
ROA
5-point trend, +9.8%
-36.3%
0.81%
ROE
5-point trend, -5.0%
-43.0%
-15.3%
ROIC
5-point trend, -60.6%
-52.1%

Kesehatan Keuangan Utang, likuiditas, solvabilitas — kekuatan neraca

Metrik
Tren 5 Tahun
CRNX
Median Rekan
Current Ratio (Rasio Lancar)
5-point trend, -42.8%
12.3
2.7
Quick Ratio (Rasio Cepat)
5-point trend, -42.1%
12.1

Pertumbuhan Pertumbuhan Pendapatan, EPS, dan Laba Bersih: YoY, CAGR 3T, CAGR 5T

Metrik
Tren 5 Tahun
CRNX
Median Rekan
Revenue YoY (Pendapatan YoY)
5-point trend, +613.9%
640.7%
Revenue CAGR 3Y (CAGR Pendapatan 3T)
5-point trend, +613.9%
17.6%
Revenue CAGR 5Y (CAGR Pendapatan 5T)
5-point trend, +613.9%
155.3%

Metrik Per Saham EPS, nilai buku per saham, arus kas per saham, dividen per saham

Metrik
Tren 5 Tahun
CRNX
Median Rekan
EPS (Diluted)
5-point trend, -76.8%
$-4.95

Efisiensi Modal Perputaran aset, perputaran persediaan, perputaran piutang

Metrik
Tren 5 Tahun
CRNX
Median Rekan

CRNX Konsensus Analis Opini analis bullish dan bearish, target harga 12 bulan, potensi kenaikan

TAHAN 21 analis
  • Beli Kuat 3 14,3%
  • Beli 4 19,0%
  • Tahan 14 66,7%
  • Jual 0 0,0%
  • Jual Kuat 0 0,0%

Target Harga 12 Bulan

10 analis · 2026-08-13
Target median $85.00 +0,3%
Target rata-rata $85.50 +0,9%

Riwayat Pendapatan EPS aktual vs perkiraan, kejutan %, tingkat keberhasilan, tanggal pendapatan berikutnya

Kejutan Rata-rata
-0.01%
Periode EPS Aktual EPS Estimasi Kejutan
30 Juni 2026 $-1.14 $-1.23 0.09%
31 Maret 2026 $-1.23 $-1.26 0.03%
31 Des. 2025 $-1.29 $-1.39 0.10%
30 Sep. 2025 $-1.38 $-1.28 -0.10%
30 Juni 2025 $-1.23 $-1.12 -0.11%
31 Maret 2025 $-1.04 $-0.96 -0.08%

Perbandingan rekan (sub-industri GICS) Metrik utama vs rekan sektor

Ticker Kapitalisasi Pasar P/E Pendapatan YoY Margin Bersih ROE Margin Kotor
CRNX $4.45B -9.4 640.7% -6046.2% -43.0%
CORT $3.69B 42.4 12.8% 13.1% 15.5%
ELAN $11.25B -48.1 6.2% -4.9% -3.5% 55.0%
AXSM $9.29B -49.6 65.5% -28.7% -227.0%
LQDA $3.01B -43.1 1031.2% -43.5% -230.0%
BLTE
DFTX $1.32B -6.5 212.0% -71.0%
AMRX 57.3 8.1% 2.4% -80.0% 36.9%
LGND $3.74B 30.8 60.4% 46.4% 13.5%
LLY 46.8 44.7% 31.7% 101.2%

Fundamental Lengkap Semua metrik per tahun — laporan laba rugi, neraca, arus kas

Laporan Laba Rugi 17
Data Laporan Laba Rugi Tahunan untuk CRNX
Metrik Tren 202520242023202220212020201920182017
Revenue 9-point trend, +276.3% $8M $1M $4M $5M $1M $71.0K $1M $2M $2M
Cost of Revenue 3-point trend, +1076000.00 $1M $0 $0 · · · · · ·
R&D Expense 9-point trend, +3496.4% $332M $240M $169M $130M $84M $57M $42M $24M $9M
SG&A Expense 9-point trend, +9767.5% $191M $100M $58M $42M $25M $18M $14M $7M $2M
Operating Expenses 9-point trend, +4594.5% $524M $340M $227M $173M $109M $75M $55M $31M $11M
Operating Income 9-point trend, -5562.0% $-517M $-339M $-223M $-168M $-108M $-75M $-54M $-29M $-9M
Interest Expense · · · · · · · · $8.0K
Interest Income 9-point trend, +199857.7% $52M $41M $13M $4M $157.0K $991.0K $3M $2M $26.0K
Other Non-op 9-point trend, -1090.0% $-357.0K $-519.0K $-159.0K $5M $61.0K $1M $3M $2M $-30.0K
Pretax Income 9-point trend, -4979.6% $-465M $-298M $-209M $-164M $-108M $-74M $-50M $-27M $-9M
Income Tax 9-point trend, +180000.00 $180.0K $0 $0 $0 $0 $0 $0 $0 $0
Net Income 9-point trend, -4981.5% $-465M $-298M $-215M $-164M $-108M $-74M $-50M $-27M $-9M
EPS (Basic) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
EPS (Diluted) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
Shares (Basic) 6-point trend, +208.9% 94,057,000 80,783,000 58,071,000 51,982,000 38,436,000 30,448,000 · · ·
Shares (Diluted) 6-point trend, +208.9% 94,057,000 80,783,000 58,071,000 51,982,000 38,436,000 30,448,000 · · ·
EBITDA 8-point trend, -1686.4% $-513M $-339M $-223M $-168M $-108M $-75M $-54M $-29M ·
Neraca 24
Data Neraca Tahunan untuk CRNX
Metrik Tren 202520242023202220212020201920182017
Cash & Equivalents 9-point trend, +615.4% $102M $265M $55M $33M $201M $93M $40M $45M $14M
Short-term Investments 8-point trend, +679.1% $926M $1.09B $504M $302M $133M $78M $78M $119M ·
Receivables 2-point trend, +592000.00 $592.0K $0 · · · · · · ·
Inventory 2-point trend, +2022000.00 $2M $0 · · · · · · ·
Prepaid Expense 9-point trend, +1733.4% $18M $21M $16M $11M $11M $7M $5M $3M $973.0K
Other Current Assets 9-point trend, +1346.0% $3M $2M $448.0K $2M $912.0K $1M $668.0K $876.0K $239.0K
Current Assets 9-point trend, +6812.9% $1.05B $1.38B $574M $345M $345M $177M $123M $167M $15M
PP&E (Net) 9-point trend, +3474.0% $14M $12M $11M $4M $3M $3M $4M $4M $400.0K
PP&E (Gross) 9-point trend, +3060.2% $22M $20M $16M $8M $6M $6M $6M $5M $704.0K
Accum. Depreciation 9-point trend, +2515.8% $8M $8M $5M $4M $3M $3M $2M $741.0K $304.0K
Other Non-current Assets 7-point trend, +8472.7% · $3M $2M $37.0K $0 $40.0K $82.0K · $33.0K
Total Assets 9-point trend, +7120.5% $1.13B $1.43B $635M $352M $351M $183M $130M $171M $16M
Accounts Payable 9-point trend, +5510.7% $23M $6M $7M $7M $3M $6M $5M $5M $403.0K
Accrued Liabilities 2-point trend, +2240.8% · · · · · · · $4M $179.0K
Current Liabilities 9-point trend, +9384.1% $85M $60M $44M $28M $16M $10M $8M $8M $897.0K
Capital Leases 7-point trend, +767.2% $42M $45M $48M $2M $3M $4M $5M · ·
Other Non-current Liabilities 3-point trend, +3240000.00 $3M $829.0K $0 · · · · · ·
Total Liabilities 9-point trend, +14484.1% $134M $110M $96M $36M $19M $15M $13M $11M $920.0K
Common Stock 4-point trend, +25200.0% · · $253.0K $0 · · · $24.0K $1.0K
Retained Earnings 9-point trend, -8614.6% $-1.42B $-952M $-654M $-439M $-275M $-168M $-94M $-43M $-16M
AOCI 8-point trend, +2957.4% $2M $963.0K $977.0K $-4M $-382.0K $25.0K $148.0K $61.0K ·
Stockholders' Equity 9-point trend, +6704.2% $992M $1.32B $539M $316M $332M $169M $117M $160M $-15M
Liabilities + Equity 9-point trend, +7120.5% $1.13B $1.43B $635M $352M $351M $183M $130M $171M $16M
Shares Outstanding 9-point trend, +6067.8% 95,575,000 92,926,000 68,175,000 53,877,000 47,597,000 33,001,000 24,263,000 24,061 1,549,575
Arus Kas 13
Data Arus Kas Tahunan untuk CRNX
Metrik Tren 202520242023202220212020201920182017
D&A 9-point trend, +2946.9% $4M $3M $1M $983.0K $922.0K $948.0K $887.0K $471.0K $128.0K
Stock-based Comp 9-point trend, +33488.2% $91M $69M $41M $28M $17M $10M $6M $2M $271.0K
Deferred Tax Flat — no change across 3 periods $0 $0 $0 · · · · · ·
Other Non-cash $-8M · · · · · · · ·
Operating Cash Flow 9-point trend, -3886.9% $-378M $-230M $-169M $-115M $-89M $-62M $-46M $-19M $-9M
CapEx 9-point trend, +1795.4% $6M $4M $5M $2M $436.0K $186.0K $492.0K $1M $304.0K
Investing Cash Flow 9-point trend, +57306.6% $174M $-575M $-200M $-174M $-56M $217.0K $42M $-119M $-304.0K
Stock Issued 7-point trend, -100.0% $0 $985M $370M $117M $250M $114M · $106M ·
Net Stock Activity 6-point trend, -100.0% $0 $970M $369M $117M $250M $114M · · ·
Financing Cash Flow 9-point trend, +243.5% $41M $1.01B $391M $122M $253M $115M $67.0K $170M $12M
Net Change in Cash 8-point trend, +10176.9% · $210M $22M $-167M $108M $53M $-5M $31M $2M
Taxes Paid 3-point trend, +89000.00 $89.0K $0 $0 · · · · · ·
Free Cash Flow 8-point trend, -1770.0% $-384M $-230M $-171M $-117M $-89M $-62M $-47M $-21M ·
Profitabilitas 7
Data Profitabilitas Tahunan untuk CRNX
Metrik Tren 202520242023202220212020201920182017
Operating Margin 8-point trend, -467.9% -6714.8% -32613.5% -5547.2% -3544.1% -9990.9% -105567.6% -4512.3% -1182.5% ·
Net Margin 8-point trend, -441.4% -6046.2% -28720.7% -5345.9% -3460.4% -9985.2% -103960.6% -4226.5% -1116.8% ·
Pretax Margin 8-point trend, -441.2% -6043.9% -28720.7% -5345.9% -3460.4% -9985.2% -103960.6% -4226.5% -1116.8% ·
EBITDA Margin 8-point trend, -463.6% -6664.1% -32613.5% -5547.2% -3544.1% -9990.9% -105567.6% -4512.3% -1182.5% ·
ROA 8-point trend, -25.3% -36.3% -28.8% -43.5% -46.6% -40.3% -47.0% -33.4% -29.0% ·
ROE 8-point trend, -159.9% -43.0% -27.7% -39.5% -49.1% -41.0% -41.4% -40.9% -16.6% ·
ROIC 8-point trend, -190.8% -52.1% -25.6% -41.3% -53.1% -32.5% -44.4% -46.0% -17.9% ·
Likuiditas & Solvabilitas 2
Data Likuiditas & Solvabilitas Tahunan untuk CRNX
Metrik Tren 202520242023202220212020201920182017
Current Ratio 8-point trend, -41.4% 12.3 23.0 13.1 12.5 21.6 16.9 14.8 21.0 ·
Quick Ratio 8-point trend, -41.5% 12.1 22.7 12.7 12.1 20.9 16.3 14.2 20.7 ·
Efisiensi 3
Data Efisiensi Tahunan untuk CRNX
Metrik Tren 202520242023202220212020201920182017
Asset Turnover 8-point trend, -76.9% 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ·
Inventory Turnover 1.1 · · · · · · · ·
Receivables Turnover 26.0 · · · · · · · ·
Per Saham 5
Data Per Saham Tahunan untuk CRNX
Metrik Tren 202520242023202220212020201920182017
Book Value / Share 8-point trend, +55.9% $10.38 $14.26 $7.91 $5.87 $6.97 $5.12 $4827.89 $6.66 ·
Revenue / Share 4-point trend, -10.2% $0.08 $0.01 $0.07 $0.09 · · · · ·
Cash Flow / Share 4-point trend, -81.3% $-4.02 $-2.80 $-2.86 $-2.22 · · · · ·
Cash / Share 8-point trend, -43.2% $1.06 $2.85 $0.81 $0.61 $4.22 $2.82 $1662.04 $1.87 ·
EPS (TTM) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
Tingkat Pertumbuhan 3
Data Tingkat Pertumbuhan Tahunan untuk CRNX
Metrik Tren 202520242023202220212020201920182017
Revenue YoY 5-point trend, -54.8% 640.7% -74.1% -15.3% 339.4% 1418.3% · · · ·
Revenue CAGR 3Y 3-point trend, -93.8% 17.6% -1.2% 283.8% · · · · · ·
Revenue CAGR 5Y 155.3% · · · · · · · ·
Valuasi (TTM) 10
Data Valuasi (TTM) Tahunan untuk CRNX
Metrik Tren 202520242023202220212020201920182017
Revenue TTM 8-point trend, +217.0% $8M $1M $4M $5M $1M $71.0K $1M $2M ·
Net Income TTM 8-point trend, -1616.1% $-465M $-298M $-215M $-164M $-108M $-74M $-50M $-27M ·
Market Cap 8-point trend, +516.6% $4.45B $4.75B $2.43B $986M $1.35B $466M $608.8K $722M ·
P/E 6-point trend, -61.3% -9.4 -13.9 -9.6 -5.8 -10.1 -5.8 · · ·
P/S 8-point trend, +94.5% 578.1 4573.0 604.5 208.1 1254.4 6558.4 0.5 297.2 ·
P/B 8-point trend, -0.4% 4.5 3.6 4.5 3.1 4.1 2.8 0.0 4.5 ·
P / Tangible Book 6-point trend, +62.7% 4.5 3.6 4.5 3.1 4.1 2.8 · · ·
P / Cash Flow 8-point trend, +68.3% -11.8 -21.0 -14.6 -8.6 -15.3 -7.5 -0.0 -37.1 ·
P / FCF 8-point trend, +67.0% -11.6 -20.7 -14.2 -8.4 -15.2 -7.5 -0.0 -35.2 ·
Earnings Yield 6-point trend, +38.0% -10.6% -7.2% -10.4% -17.2% -9.9% -17.2% · · ·

Laporan Keuangan Laporan laba rugi, neraca, arus kas — tahunan, 5 tahun terakhir

Laporan Laba Rugi
2025-12-312024-12-312023-12-312022-12-312021-12-31
Pendapatan $8M$1M$4M$5M$1M
Margin Operasi % -6714.8%-32613.5%-5547.2%-3544.1%-9990.9%
Laba Bersih $-465M$-298M$-215M$-164M$-108M
EPS Dilusian $-4.95$-3.69$-3.69$-3.15$-2.80
Neraca
2025-12-312024-12-312023-12-312022-12-312021-12-31
Rasio Lancar 12.323.013.112.521.6
Rasio Cepat 12.122.712.712.120.9
Arus Kas
2025-12-312024-12-312023-12-312022-12-312021-12-31
Arus Kas Bebas $-384M$-230M$-171M$-117M$-89M

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Pemilik institusional (13F) 287 pengaju · $3.2B total · Per tanggal 30 Juni 2026

Institusi yang melaporkan kepemilikan saham ini dalam SEC Form 13F triwulanan mereka. Hanya posisi panjang; satu pengaju dapat muncul dua kali untuk leg opsi terpisah. Kaki put/call offset yang besar biasanya mencerminkan pembuatan pasar atau inventaris yang dilindungi, bukan keyakinan arah.

Aktivitas institusional — Q2 2026 vs kuartal sebelumnya
Posisi baru Posisi yang keluar Meningkat Menurun Perubahan bersih saham
63 (+17 vs Kuartal sebelumnya) 30 (-14 vs Kuartal sebelumnya) 95 (-17 vs Kuartal sebelumnya) 63 (+3 vs Kuartal sebelumnya) +21.6M

Dibandingkan dengan Q1 2026. Pengajuan Formulir 13F SEC jatuh tempo dalam waktu 45 hari setelah akhir kuartal ditambah kelonggaran singkat untuk pengaju terlambat — kuartal yang masih dalam jangka waktu tersebut dilewati demi pasangan terakhir yang dilaporkan sepenuhnya.

Institusi Nilai Saham % dari 13F yang dilacak Tipe
FMR LLC $486.250.673 12.994.406 15,13% Saham
FARALLON CAPITAL MANAGEMENT, L.L.C. $336.372.047 8.989.098 10,46% Saham
Driehaus Capital Management LLC $241.866.078 6.463.551 7,52% Saham
WELLINGTON MANAGEMENT GROUP LLP $237.002.526 6.333.579 7,37% Saham
VANGUARD PORTFOLIO MANAGEMENT LLC $180.836.416 4.832.614 5,63% Saham
VANGUARD CAPITAL MANAGEMENT LLC $177.567.704 4.745.262 5,52% Saham
STATE STREET CORP $100.635.477 2.689.350 3,13% Saham
Bellevue Group AG $98.040.400 2.620.000 3,05% Saham
BAKER BROS. ADVISORS LP $87.991.820 2.351.465 2,74% Saham
GEODE CAPITAL MANAGEMENT, LLC $87.542.675 2.338.905 2,72% Saham
Polar Capital Holdings Plc $85.108.460 2.274.411 2,65% Saham
Pictet Asset Management Holding SA $77.572.984 2.075.375 2,41% Saham
Siren, L.L.C. $53.165.887 1.420.788 1,65% Saham
First Light Asset Management, LLC $50.923.606 1.360.866 1,58% Saham
NOVO HOLDINGS A/S $49.394.400 1.320.000 1,54% Saham
AMERICAN CENTURY COMPANIES INC $47.245.129 1.262.562 1,47% Saham
ADAR1 Capital Management, LLC $45.730.234 1.222.080 1,42% Saham
DIMENSIONAL FUND ADVISORS LP $44.555.208 1.190.679 1,39% Saham
MONTANOVA CAPITAL, LLC $44.390.560 1.186.279 1,38% Saham
ORBIMED ADVISORS LLC $37.382.580 999.000 1,16% Saham
Hood River Capital Management LLC $36.259.830 968.996 1,13% Saham
GOLDMAN SACHS GROUP INC $34.657.132 926.166 1,08% Saham
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $32.841.401 877.643 1,02% Saham
Aberdeen Group plc $30.699.181 820.395 0,95% Saham
Candriam S.C.A. $30.618.690 819.032 0,95% Saham
VANGUARD FIDUCIARY TRUST CO $28.230.995 754.436 0,88% Saham
Fisher Asset Management, LLC $27.748.912 741.553 0,86% Saham
SCHRODER INVESTMENT MANAGEMENT GROUP $17.709.036 479.400 0,55% Saham
AMERIPRISE FINANCIAL INC $17.451.149 466.356 0,54% Saham
Impax Asset Management Group plc $16.277.700 435.000 0,51% Saham
Prosight Management, LP $14.020.002 374.666 0,44% Saham
Universal- Beteiligungs- und Servicegesellschaft mbH $13.991.714 373.910 0,44% Saham
KENNEDY CAPITAL MANAGEMENT LLC $13.685.018 365.714 0,43% Saham
BRAUN STACEY ASSOCIATES INC $13.027.511 348.143 0,41% Saham
Fiera Capital Corp $12.395.263 331.247 0,39% Saham
BANK OF AMERICA CORP /DE/ $11.271.877 301.226 0,35% Saham
Defilade Capital Management, L.P. $8.959.845 239.440 0,28% Saham
SEB Asset Management AB $8.003.786 213.891 0,25% Saham
Foresite Capital Management VI LLC $7.933.414 212.010 0,25% Saham
RICE HALL JAMES & ASSOCIATES, LLC $7.346.220 196.318 0,23% Saham
TD Asset Management Inc $7.152.534 191.142 0,22% Saham
Swiss National Bank $6.877.796 183.800 0,21% Saham
SEGALL BRYANT & HAMILL, LLC $6.855.307 183.199 0,21% Saham
BlackRock, Inc. $6.781.290 181.221 0,21% Saham
JENNISON ASSOCIATES LLC $6.056.839 161.861 0,19% Saham
New Leaf Venture Partners, L.L.C. $5.872.650 141.000 0,18% Saham
SILVERCREST ASSET MANAGEMENT GROUP LLC $5.865.136 156.738 0,18% Saham
Foresite Capital Management IV, LLC $5.613.000 150.000 0,17% Saham
Bank of New York Mellon Corp $5.581.754 149.165 0,17% Saham
NEW YORK STATE COMMON RETIREMENT FUND $5.508.898 147.218 0,17% Saham
ENVESTNET ASSET MANAGEMENT INC $5.471.384 146.216 0,17% Saham
Moody Aldrich Partners LLC $5.466.201 146.077 0,17% Saham
Ishara Investments LP $5.369.770 143.500 0,17% Saham
CITADEL ADVISORS LLC $5.176.271 138.329 0,16% Saham
RHUMBLINE ADVISERS $4.861.141 129.908 0,15% Saham
ALLIANCEBERNSTEIN L.P. $4.782.618 131.680 0,15% Saham
GordonMD Global Investments LP $4.751.779 126.985 0,15% Saham
MANUFACTURERS LIFE INSURANCE COMPANY, THE $4.712.974 125.948 0,15% Saham
JANUS HENDERSON GROUP PLC $4.700.428 129.392 0,15% Saham
Cormorant Asset Management, LP $4.677.500 125.000 0,15% Saham
SECTOR GAMMA AS $4.289.380 114.628 0,13% Saham
XTX Topco Ltd $4.164.547 111.292 0,13% Saham
ALPS ADVISORS INC $3.981.825 106.409 0,12% Saham
FEDERATED HERMES, INC. $3.957.390 105.756 0,12% Saham
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $3.834.048 105.563 0,12% Saham
Nuveen Asset Management, LLC $3.760.151 73.541 0,12% Saham
Burkehill Global Management, LP $3.742.000 100.000 0,12% Saham
Nuveen, LLC $3.619.262 96.720 0,11% Saham
VICTORY CAPITAL MANAGEMENT INC $3.484.251 93.112 0,11% Saham
MORGAN STANLEY $3.320.829 88.744 0,10% Saham
TWO SIGMA INVESTMENTS, LP $3.266.729 87.299 0,10% Saham
VANGUARD ASSET MANAGEMENT, Ltd $3.254.754 86.979 0,10% Saham
AWM Investment Company, Inc. $3.180.700 85.000 0,10% Saham
Odyssean, LLC $3.160.344 84.456 0,10% Saham
Affinity Asset Advisors, LLC $2.806.500 75.000 0,09% Saham
ALGERT GLOBAL LLC $2.714.147 72.532 0,08% Saham
ExodusPoint Capital Management, LP $2.652.404 70.882 0,08% Saham
Ensign Peak Advisors, Inc $2.507.290 67.004 0,08% Saham
BARCLAYS PLC $2.466.127 65.904 0,08% Saham
FIRST TRUST ADVISORS LP $2.370.631 63.352 0,07% Saham
Man Group plc $2.284.229 61.043 0,07% Saham
MetLife Investment Management, LLC $2.258.709 60.361 0,07% Saham
CITIGROUP INC $2.255.229 60.268 0,07% Saham
Longaeva Partners L.P. $2.184.879 58.388 0,07% Saham
Swedbank AB $2.155.392 57.600 0,07% Saham
STATE OF WISCONSIN INVESTMENT BOARD $2.068.016 55.265 0,06% Saham
Jump Financial, LLC $1.923.388 51.400 0,06% Saham
Lighthouse Investment Partners, LLC $1.871.000 50.000 0,06% Saham
Vestmark Advisory Solutions, Inc. $1.823.252 48.724 0,06% Saham
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $1.787.254 47.762 0,06% Saham
VANGUARD GROUP INC $1.774.626 38.123 0,06% Saham
Point72 Asset Management, L.P. $1.735.577 46.381 0,05% Saham
BNP PARIBAS FINANCIAL MARKETS $1.696.398 45.334 0,05% Saham
RAYMOND JAMES FINANCIAL INC $1.606.254 42.925 0,05% Saham
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1.549.188 41.400 0,05% Opsi beli
Invesco Ltd. $1.545.446 41.300 0,05% Saham
Vanguard Global Advisers, LLC $1.485.986 39.711 0,05% Saham
HighMark Wealth Management LLC $1.444.224 38.595 0,04% Saham
OAK RIDGE INVESTMENTS LLC $1.405.046 37.548 0,04% Saham
Orion Porfolio Solutions, LLC $1.404.234 37.526 0,04% Saham

Orang dalam perusahaan 20 orang dalam · 9 pejabat · 10 direktur

Orang Dalam Peran Aktivitas terakhir Saham dimiliki Beli 12m Jual 12m Bersih 12m
Tobin Schilke Chief Financial Officer 10 Maret 2025 A 52.000 0 0 $0
Marc Wilson CFO 26 Sep. 2024 M 111.092 0 0 $0
Jeff E. Knight Chief Operating Officer 19 Maret 2025 S 87.491 0 0 $0
Stephen F. Betz Chief Scientific Officer 12 Juni 2025 M 99.713 0 0 $0
Dana Pizzuti Chief Med and Dev Officer 19 Maret 2025 S 72.233 0 0 $0
Isabel Kalofonos Chief Commercial Officer 10 Jan. 2025 A 0 0 $0
James Hassard Chief Commercial Officer 5 Juli 2024 M 29.259 0 0 $0
Alan Seth Krasner Chief Medical Officer 17 Okt. 2023 M 43.210 0 0 $0
Ajay Madan Chief Development Officer 28 Feb. 2022 A 176.995 0 0 $0
Coelho Rogerio Vivaldi Direktur 2 Juli 2026 S 19.225 0 1 $-120.000
Caren Deardorf Direktur 18 Juni 2026 A 22.225 0 0 $0
Weston Nichols Direktur 18 Juni 2026 A 22.225 0 0 $0
Stephanie Okey Direktur 18 Juni 2026 A 12.325 0 2 $-246.143
Matthew K Fust Direktur 18 Juni 2026 A 28.761 0 0 $0
Camille L Bedrosian Direktur 18 Juni 2026 A 22.225 0 0 $0
Wendell Wierenga Direktur 18 Juni 2026 A 122.071 0 0 $0
Wendall Wierenga Direktur 11 Juni 2025 A 116.146 0 0 $0
Stephen W Kaldor Direktur 19 Juni 2020 A 0 0 $0
Jack Nielsen Direktur 21 Juni 2019 A 0 0 $0
Richard Scott Struthers 7 Agu 2026 M 424.706 0 0 $0

Orang dalam dari pengajuan SEC Form 3/4/5; bersih = hanya P/S pasar terbuka

Aktivis & pemilik 5%+ 1 saham

Investor yang mengajukan Jadwal 13D SEC — kepemilikan manfaat di atas 5% dengan niat untuk memengaruhi penerbit (kepemilikan aktivis, kampanye dewan, M&A). Setiap baris menunjukkan status terbaru yang diketahui dari posisi pengaju tersebut.

Pengaju Diajukan Kepemilikan Status Tujuan Pengajuan
Perceptive Advisors LLC, Joseph Edelman, Perceptive Life Sciences Master Fund, Ltd. ×6 pengajuan 1 Maret 2024 Pengajuan awal SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Kepemilikan ETF Dimiliki oleh 55 ETF

Bobot mencerminkan kepemilikan ekuitas langsung (N-PORT) saja; dana berbasis leverage atau derivatif mungkin memiliki eksposur swap tambahan yang tidak ditampilkan.

Dana Bobot Unit Per tanggal Sumber
SBIO · ALPS ETF Trust 2,37% 107.892 NS 31 Mei 2026 N-PORT
IHE · iShares Trust 1,95% 376.636 SH 8 Agu 2026 Harian
FMED · Fidelity Covington Trust 1,65% 19.000 NS 31 Mei 2026 N-PORT
PILL · Direxion Shares ETF Trust 1,40% 4.666 NS 30 April 2026 N-PORT
BBP · ETFis Series Trust I 1,23% 18.743 NS 30 April 2026 N-PORT
MMSC · First Trust Exchange-Traded Fund VI… 0,75% 11.043 NS 31 Mei 2026 N-PORT
IBB · iShares Trust 0,63% 718.323 SH 8 Agu 2026 Harian
IBBQ · Invesco Exchange-Traded Fund Trust … 0,60% 5.737 SH 8 Agu 2026 Harian
IWO · iShares Trust 0,54% 940.202 SH 8 Agu 2026 Harian
NUSC · Nushares ETF Trust 0,28% 93.045 NS 30 April 2026 N-PORT
ISCG · iShares Trust 0,27% 32.694 SH 8 Agu 2026 Harian
IWM · iShares Trust 0,27% 2.625.192 SH 8 Agu 2026 Harian
VTWG · VANGUARD SCOTTSDALE FUNDS 0,23% 110.770 SH 8 Agu 2026 Harian
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0,20% 38.553 NS 30 April 2026 N-PORT
BIB · ProShares Trust 0,19% 3.872 NS 31 Mei 2026 N-PORT
ESML · iShares Trust 0,16% 55.438 SH 8 Agu 2026 Harian
BKSE · BNY Mellon ETF Trust 0,15% 3.142 NS 30 April 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0,15% 51.135 SH 8 Agu 2026 Harian
FNY · First Trust Exchange-Traded AlphaDE… 0,14% 18.879 NS 30 April 2026 N-PORT
ISCB · iShares Trust 0,13% 4.625 SH 8 Agu 2026 Harian
VTWO · VANGUARD SCOTTSDALE FUNDS 0,12% 596.648 SH 8 Agu 2026 Harian
RSSL · Global X Funds 0,12% 42.391 NS 30 April 2026 N-PORT
VBK · VANGUARD INDEX FUNDS 0,11% 1.399.667 SH 8 Agu 2026 Harian
FFSM · FIDELITY COVINGTON TRUST 0,10% 31.759 NS 30 April 2026 N-PORT
ITWO · ProShares Trust 0,09% 4.601 NS 31 Mei 2026 N-PORT
OMFS · Invesco Exchange-Traded Self-Indexe… 0,09% 2.909 SH 8 Agu 2026 Harian
SCHA · SCHWAB STRATEGIC TRUST 0,08% 492.431 NS 31 Mei 2026 N-PORT
FNX · First Trust Exchange-Traded AlphaDE… 0,07% 24.991 NS 30 April 2026 N-PORT
WSML · iShares Trust 0,07% 5.742 SH 8 Agu 2026 Harian
FHLC · FIDELITY COVINGTON TRUST 0,06% 41.183 NS 30 April 2026 N-PORT
DFAS · Dimensional ETF Trust 0,05% 196.549 NS 30 April 2026 N-PORT
UWM · ProShares Trust 0,05% 3.599 NS 31 Mei 2026 N-PORT
VB · VANGUARD INDEX FUNDS 0,05% 2.419.186 SH 8 Agu 2026 Harian
VHT · VANGUARD WORLD FUND 0,05% 275.155 SH 8 Agu 2026 Harian
FAD · First Trust Exchange-Traded AlphaDE… 0,04% 5.196 NS 30 April 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0,04% 1.210.574 SH 8 Agu 2026 Harian
AVIE · AMERICAN CENTURY ETF TRUST 0,04% 112 NS 31 Mei 2026 N-PORT
URTY · ProShares Trust 0,04% 3.643 NS 31 Mei 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0,02% 5.689 NS 31 Mei 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0,02% 3.773 NS 31 Mei 2026 N-PORT
HDG · ProShares Trust 0,02% 91 NS 31 Mei 2026 N-PORT
ITOT · iShares Trust 0,01% 146.419 SH 8 Agu 2026 Harian
IWV · iShares Trust 0,01% 27.043 SH 8 Agu 2026 Harian
DFAC · Dimensional ETF Trust 0,01% 125.853 NS 30 April 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0,01% 3.342.704 SH 8 Agu 2026 Harian
VTHR · VANGUARD SCOTTSDALE FUNDS 0,01% 8.345 SH 8 Agu 2026 Harian
ESGV · VANGUARD WORLD FUND 0,01% 22.843 SH 8 Agu 2026 Harian
ONEQ · Fidelity Commonwealth Trust 0,01% 28.694 NS 31 Mei 2026 N-PORT
DCOR · Dimensional ETF Trust 0,01% 5.863 NS 30 April 2026 N-PORT
TILT · FlexShares Trust 0,01% 3.388 NS 30 April 2026 N-PORT