BCRX BioCryst Pharmaceuticals, Inc. - Common Stock

NASDAQ · Biotechnology · Visualizza su SEC EDGAR ↗
$9,88
Prezzo · Ago 18, 2026
Fondamentali al Ago 5, 2026

Informazioni su BioCryst Pharmaceuticals, Inc. - Common Stock Panoramica della società da Wikipedia

BioCryst Pharmaceuticals, Inc. is an American pharmaceutical company headquartered in Durham, North Carolina. The company is a commercial stage biotech company that focuses on developing and commercializing medicines for hereditary angioedema (HAE) and other rare diseases. BioCryst's antiviral drug peramivir (Rapivab) was approved by the FDA in December 2014 and berotralstat (ORLADEYO) was approved in December 2020.

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BioCryst Pharmaceuticals, Inc. is an American pharmaceutical company headquartered in Durham, North Carolina. The company is a commercial stage biotech company that focuses on developing and commercializing medicines for hereditary angioedema (HAE) and other rare diseases. BioCryst's antiviral drug peramivir (Rapivab) was approved by the FDA in December 2014 and berotralstat (ORLADEYO) was approved in December 2020.

History

The company was founded in 1986 by Charles E. Bugg and John A. Montgomery. In March 1994, BioCryst became a public company when it completed an initial public offering by listing its shares on the NASDAQ stock exchange. In 2008, the company was named one of the fastest growing companies by Deloitte & Touche in its 2008 list of Technology Fast 500.

In October 2010, BioCryst announced its headquarters would move to Durham, North Carolina, where the company has had an office since 2006. In January 2018, BioCryst signed a definitive merger agreement with Idera Pharmaceuticals, with plans for the combined company to change its name and move to Pennsylvania. However, BioCryst shareholders voted down the merger in July.

Pipeline

BioCryst’s core development programs include:

Berotralstat (BCX7353), an oral inhibitor of plasma kallikrein for prevention and treatment of hereditary angioedema (HAE).

FDA has approved Expanded Access Program for berotralstat for eligible patients in the United States.

Berotralstat has a PDUFA date for FDA approval on December 3, 2020.

On December 3, 2020, the FDA approved berotralstat as the first oral hereditary angioedema prophylaxis.

BCX9930, an oral Factor D inhibitor for the treatment of complement-mediated diseases.

FDA has granted Fast Track designation for BCX9930, for the treatment of paroxysmal nocturnal hemoglobinuria (PNH).

BCX9250, an oral ALK-2 inhibitor for treatment of fibrodysplasia ossificans progressiva (FOP).

Galidesivir (BCX4430) is a broad-spectrum antiviral in advanced development for the treatment of viruses including SARS-CoV-2 (the cause of COVID-19), Ebola, Marburg, Yellow Fever and Zika.

Galidesivir was safe and generally well tolerated in Phase 1 clinical safety and pharmacokinetics trials conducted in 2019 by both intravenous and intramuscular routes of administration in healthy human subjects.

In animal studies, galidesivir has demonstrated survival benefits against a variety of serious pathogens, including Ebola, Marburg, Yellow Fever and Zika viruses.

BioCryst is developing galidesivir in collaboration with U.S. government agencies and other institutions.

In September 2013, NIAID contracted with BioCryst for the development of galidesivir as a treatment for Marburg virus disease and potentially for other filoviruses, including Ebola virus.

In March 2015, BioCryst announced that the Biomedical Advanced Research and Development Authority (BARDA) within the U.S. Department of Health & Human Services’ Office of the Assistant Secretary for Preparedness and Response (ASPR) has awarded BioCryst a contract for the continued development of galidesivir as a potential treatment for diseases caused by RNA pathogens, including filoviruses.

In April 2020, BioCryst began enrollment of a randomized, double-blind, placebo-controlled clinical trial to assess the safety, clinical impact and antiviral effects of galidesivir in patients with COVID-19. This clinical trial is (NCT03891420) is being funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The company later made the decision to cease conducting further trials.

Fonte: Wikipedia (Inglese), CC BY-SA 4.0 · Vedi su Wikipedia ↗

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BCRX Snapshot del titolo Prezzo, capitalizzazione di mercato, P/E, EPS, ROE, debito/capitale proprio, intervallo 52 settimane

Prezzo
$9.88
Capitalizzazione di Mercato
$2.51B
P/E (TTM)
9.7
EPS (TTM)
$1.21
Ricavi (TTM)
$875M
Rendimento div.
ROE
-97.6%
D/E Debito/Patrimonio
0.0
Intervallo 52 sett.
$6 – $11

BCRX Grafico del prezzo delle azioni OHLCV giornaliero con indicatori tecnici — panoramica, zoom e personalizza la tua visualizzazione

Performance decennale Andamento di ricavi, utile netto, margini e EPS

Ricavi e Utile Netto $875M
10-point trend, +3219.7%
2016-12-31 2025-12-31
EPS $1.21
6-point trend, +211.0%
2020-12-31 2025-12-31
Flusso di cassa libero $345M
9-point trend, +687.4%
2016-12-31 2025-12-31
Margini 30.2%

Valutazione Rapporti P/E, P/S, P/B, EV/EBITDA — il titolo è costoso o economico?

Metrica
Tendenza 5 anni
BCRX
Mediana dei peer
P/E (TTM)
5-point trend, +147.9%
9.7
97.6
P/S (TTM)
5-point trend, -88.3%
2.9
7.7
P/B
5-point trend, +41.6%
-21.1
8.0
EV / EBITDA
5-point trend, +132.8%
6.5
Price / FCF (Prezzo / FCF)
5-point trend, +127.3%
7.3

Redditività Margini lordi, operativi e netti; ROE, ROA, ROIC

Metrica
Tendenza 5 anni
BCRX
Mediana dei peer
Operating Margin (Margine Operativo)
5-point trend, +134.5%
39.0%
Net Profit Margin (Margine di Profitto Netto)
5-point trend, +125.8%
30.2%
-51.7%
ROA
5-point trend, +231.7%
52.5%
-44.2%
ROE
5-point trend, -167.3%
-97.6%
-63.5%
ROIC
5-point trend, +54.3%
-282.4%

Salute finanziaria Debito, liquidità, solvibilità — solidità del bilancio

Metrica
Tendenza 5 anni
BCRX
Mediana dei peer
Debt / Equity (Debito / Patrimonio Netto)
5-point trend, +100.0%
0.0
18.7
Current Ratio (Rapporto corrente)
5-point trend, -62.2%
2.1
4.9
Quick Ratio
5-point trend, -62.2%
1.9

Crescita Crescita di ricavi, EPS e utile netto: YoY, CAGR 3Y, CAGR 5Y

Metrica
Tendenza 5 anni
BCRX
Mediana dei peer
Revenue YoY (Ricavi YoY)
5-point trend, +456.6%
94.1%
Revenue CAGR 3Y (CAGR Ricavi 3Y)
5-point trend, +456.6%
47.8%
Revenue CAGR 5Y (CAGR Ricavi 5Y)
5-point trend, +456.6%
117.9%

Metriche per Azione EPS, valore contabile per azione, flusso di cassa per azione, dividendo per azione

Metrica
Tendenza 5 anni
BCRX
Mediana dei peer
EPS (Diluted) (EPS (Diluito))
5-point trend, +217.5%
$1.21

Efficienza del Capitale Rotazione delle attività, rotazione delle scorte, rotazione dei crediti

Metrica
Tendenza 5 anni
BCRX
Mediana dei peer

BCRX Consenso degli analisti Opinioni degli analisti, sia rialziste che ribassiste, target price a 12 mesi, potenziale di rialzo

COMPRA 17 analisti
  • Acquisto forte 5 29,4%
  • Compra 10 58,8%
  • Mantieni 2 11,8%
  • Vendi 0 0,0%
  • Vendita forte 0 0,0%

Target Price a 12 Mesi

11 analisti · 2026-08-17
Target mediano $17.00 +72,1%
Target medio $20.82 +110,7%

Cronologia utili EPS effettivo vs stima, surprise %, tasso di superamento, data prossimi utili

Sorpresa media
0.02%
Periodo EPS Actual EPS Stimato Sorpresa
30 Giugno 2026 $0.30 $0.12 0.18%
31 Marzo 2026 $-0.09 $0.05 -0.14%
31 Dicembre 2025 $0.01 $0.04 -0.03%
30 Settembre 2025 $0.06 $0.04 0.02%
30 Giugno 2025 $0.04 $0.01 0.03%
31 Marzo 2025 $0.00 $-0.07 0.07%

Confronto Peer (GICS sub-settore industriale) Metriche chiave rispetto ai pari del settore

Ticker Capitalizzazione di Mercato P/E Rev YoY Margine Netto ROE Margine lordo
BCRX $1.66B 6.4 94.1% 30.2% -97.6%
BEAM $2.82B -34.2 120.0% -57.2% -7.0%
KOD $1.73B -6.5 -202.0%
SLS $577M -15.1 -55.4%
RARE $2.22B -3.9 20.2% -85.4% -1613.2%
COAG
KLRA
CDNA $959M -47.1 13.8% -5.6% -6.8%
PGEN $1.48B -3.1 146.7% -2588.2% 3159.1%
VERA -10.9 -55.9%
MLYS $2.96B -15.8 -32.2%

Fondamentali Completi Tutte le metriche per anno — conto economico, stato patrimoniale, rendiconto finanziario

Conto Economico 16
Dati annuali Conto Economico per BCRX
Metrica Tendenza 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +6328.8% $875M $451M $331M $271M $157M $18M $49M $21M $25M $26M $48M $14M
Cost of Revenue 11-point trend, +1907400.0% $19M $12M $4M $6M $7M $2M $4M · $1M $2M $1M $1.0K
R&D Expense 12-point trend, +220.7% $166M $175M $217M $253M $209M $123M $107M $85M $67M $61M $73M $52M
SG&A Expense 12-point trend, +4572.9% $349M $266M $214M $159M $119M $68M $37M $30M $14M $11M $13M $7M
Operating Expenses 12-point trend, +799.1% $534M $453M $435M $419M $335M $193M $148M $115M $83M $75M $88M $59M
Operating Income 12-point trend, +845.0% $341M $-3M $-104M $-148M $-178M $-175M $-99M $-94M $-57M $-49M $-39M $-46M
Interest Expense 10-point trend, +2065.6% · · $108M $99M $59M $15M $12M $9M $9M $6M $5M $5M
Other Non-op 4-point trend, +23.3% $-74M $-84M $-123M $-96M · · · · · · · ·
Pretax Income 7-point trend, +345.5% $267M $-87M $-226M $-244M $-182M $-183M $-109M · · · · ·
Income Tax 11-point trend, +3530000.00 $4M $2M $310.0K $3M $2M $0 $0 $0 $0 $0 $0 ·
Net Income 12-point trend, +683.9% $264M $-89M $-227M $-247M $-184M $-183M $-109M $-101M $-66M $-55M $-43M $-45M
EPS (Basic) 6-point trend, +215.6% $1.26 $-0.43 $-1.18 $-1.33 $-1.03 $-1.09 · · · · · ·
EPS (Diluted) 6-point trend, +211.0% $1.21 $-0.43 $-1.18 $-1.33 $-1.03 $-1.09 · · · · · ·
Shares (Basic) 6-point trend, +25.5% 209,893,000 206,696,000 192,198,000 185,908,000 179,117,000 167,267,000 · · · · · ·
Shares (Diluted) 12-point trend, +227.3% 218,581,000 206,696,000 192,198,000 185,908,000 179,117,000 167,267,000 115,600,000 103,185,000 84,451,000 73,699,000 72,901,000 66,773,000
EBITDA 11-point trend, +850.9% $342M $-1M $-102M $-147M $-177M $-174M $-99M $-93M · $-48M $-39M $-46M
Stato Patrimoniale 27
Dati annuali Stato Patrimoniale per BCRX
Metrica Tendenza 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +64.5% $90M $105M $111M $305M $504M $272M $114M $27M $50M $22M $29M $55M
Short-term Investments 2-point trend, -14.4% $185M $216M · · · · · · · · · ·
Receivables 12-point trend, +2675.2% $107M $79M $57M $51M $29M $9M $22M $4M $6M $9M $6M $4M
Inventory 11-point trend, +690.3% $5M $8M $29M $28M $16M $7M $0 $2M · $500.0K $2M $683.0K
Prepaid Expense 12-point trend, +178.4% $17M $14M $20M $13M $10M $6M $4M $2M $1M $1M $3M $6M
Current Assets 12-point trend, +352.6% $404M $422M $496M $516M $566M $324M $164M $114M $125M $67M $64M $89M
PP&E (Net) 12-point trend, +4143.0% $9M $8M $8M $9M $9M $7M $7M $9M $10M $10M $5M $207.0K
PP&E (Gross) 12-point trend, +27.7% $18M $20M $19M $18M $17M $14M $14M $15M $15M $15M $19M $14M
Accum. Depreciation 12-point trend, -33.0% $9M $12M $11M $10M $8M $7M $7M $6M $5M $5M $14M $14M
Other Non-current Assets 12-point trend, -6.0% $6M $5M $80.0K $7M $6M $4M $4M $978.0K $2M $4M $5M $6M
Total Assets 12-point trend, +275.6% $514M $490M $517M $550M $588M $335M $175M $147M $178M $90M $122M $137M
Accounts Payable 12-point trend, +455.5% $16M $12M $21M $14M $28M $19M $14M $8M $6M $4M $9M $3M
Accrued Liabilities 12-point trend, +1015.8% $126M $113M $103M $88M $73M $34M $21M $16M $13M $11M $16M $11M
Short-term Debt 7-point trend, +0.0% · · · · · $30M $30M $29M $29M $28M $28M $30M
Current Liabilities 12-point trend, +242.2% $196M $160M $150M $106M $104M $106M $92M $69M $75M $54M $62M $57M
Capital Leases 6-point trend, +121.4% $9M $8M $8M $4M $6M $4M · · · · · ·
Other Non-current Liabilities · · · · · · · $3M · · · ·
Total Liabilities 3-point trend, -34.9% $633M $966M $972M · · · · · · · · ·
Long-term Debt 6-point trend, +1196.3% · · · · $298M $123M $50M $30M $23M $23M · ·
Total Debt 11-point trend, -100.0% $0 $315M $303M $232M $136M $150M $30M $29M · $28M $30M $30M
Common Stock 12-point trend, +196.0% $2M $2M $2M $2M $2M $2M $2M $1M $984.0K $738.0K $734.0K $720.0K
Paid-in Capital 12-point trend, +155.1% $1.38B $1.29B $1.22B $1.16B $1.10B $1.00B $877M $780M $715M $567M $558M $543M
Retained Earnings 12-point trend, -221.9% $-1.51B $-1.77B $-1.68B $-1.45B $-1.21B $-1.02B $-841M $-732M $-632M $-566M $-511M $-468M
AOCI 12-point trend, +129.2% $38.0K $921.0K $1M $26.0K $177.0K $3.0K $39.0K $-297.0K $-243.0K $-12.0K $-206.0K $-130.0K
Stockholders' Equity 12-point trend, -257.5% $-119M $-476M $-456M $-295M $-107M $-19M $38M $49M $84M $2M $48M $76M
Liabilities + Equity 12-point trend, +275.6% $514M $490M $517M $550M $588M $335M $175M $147M $178M $90M $122M $137M
Shares Outstanding 12-point trend, +196.1% 213,060,000 208,543,000 205,771,000 187,906,000 184,350,000 176,883,000 154,082,000 110,063,000 98,411,000 73,782,000 73,355,000 71,955,000
Flusso di cassa 16
Dati annuali Flusso di cassa per BCRX
Metrica Tendenza 202520242023202220212020201920182017201620152014
D&A 12-point trend, +684.7% $1M $1M $2M $1M $777.0K $748.0K $724.0K $770.0K $704.0K $483.0K $180.0K $177.0K
Stock-based Comp 12-point trend, +735.9% $85M $65M $56M $45M $35M $15M $18M $9M $13M $8M $10M $10M
Deferred Tax 5-point trend, -662.3% $-1M $-354.0K $-682.0K $11.0K $-159.0K · · · · · · ·
Other Non-cash 11-point trend, +53.3% $-2M $-29M $75M $39M $6M $30M $870.0K $-1M · $-7M $20M $-4M
Operating Cash Flow 12-point trend, +1001.1% $347M $-52M $-95M $-162M $-142M $-135M $-90M $-93M $-41M $-53M $-13M $-39M
CapEx 12-point trend, +2228.3% $2M $1M $2M $1M $2M $514.0K $343.0K $366.0K $328.0K $5M $5M $106.0K
Investing Cash Flow 11-point trend, +23.9% $-14M $53M $-131M $-128M $16M $-7M $78M $5M $-65M $23M $-18M ·
Debt Issued 5-point trend, +0.00 $0 $0 $300M $73M $0 · · · · · · ·
Net Debt Issued 3-point trend, -200.0% $-300M $0 $300M · · · · · · · · ·
Stock Issued 8-point trend, -100.0% · · $0 $0 $50M $93M $58M $53M $134M · · $107M
Net Stock Activity 7-point trend, -100.0% · · $0 $0 $50M $93M $58M $53M · · · $107M
Financing Cash Flow 11-point trend, -6486.8% $-350M $-6M $32M $88M $360M $301M $99M $63M $136M $23M $5M ·
Net Change in Cash 12-point trend, -144.9% $-15M $-6M $-194M $-201M $233M $159M $87M $-25M $30M $-7M $-26M $33M
Taxes Paid 3-point trend, +95.5% $3M $2M $1M · · · · · · · · ·
Free Cash Flow 11-point trend, +992.2% $345M $-53M $-97M $-163M $-145M $-138M $-90M $-93M · $-59M $-18M $-39M
Levered FCF 4-point trend, -35.1% · · $-206M $-263M $-205M $-152M · · · · · ·
Redditività 7
Dati annuali Redditività per BCRX
Metrica Tendenza 202520242023202220212020201920182017201620152014
Operating Margin 11-point trend, +111.6% 39.0% -0.56% -31.3% -54.8% -113.1% -981.1% -203.7% -456.2% · -184.4% -81.7% -336.4%
Net Margin 11-point trend, +109.1% 30.2% -19.7% -68.4% -91.2% -117.1% -1026.4% -223.0% -490.2% · -209.2% -89.1% -332.1%
Pretax Margin 6-point trend, +103.0% 30.6% -19.3% -68.3% -90.2% -115.7% -1026.4% · · · · · ·
EBITDA Margin 11-point trend, +111.7% 39.1% -0.29% -30.8% -54.3% -112.6% -976.9% -202.2% -452.5% · -182.6% -81.4% -335.0%
ROA 11-point trend, +208.0% 52.5% -17.6% -42.5% -43.4% -39.9% -71.7% -67.6% -62.3% · -52.0% -32.9% -48.7%
ROE 11-point trend, +19.5% -97.6% 18.8% 52.3% 92.0% 144.9% -2543.5% 7257.4% -165.8% · -223.7% -69.8% -121.3%
ROIC 6-point trend, -110.8% -282.4% 1.6% 68.2% 238.4% -618.4% -133.9% · · · · · ·
Liquidità e Solvibilità 5
Dati annuali Liquidità e Solvibilità per BCRX
Metrica Tendenza 202520242023202220212020201920182017201620152014
Current Ratio 11-point trend, +33.2% 2.1 2.6 3.3 4.9 5.5 3.1 1.8 1.6 · 1.2 1.0 1.5
Quick Ratio 11-point trend, +105.8% 1.9 1.1 1.1 3.4 5.1 2.7 1.5 0.4 · 0.6 0.5 0.9
Debt / Equity 11-point trend, -100.0% 0.0 -0.7 -0.7 -0.8 -1.3 -7.8 0.8 0.6 · 17.9 0.6 0.4
LT Debt / Equity 6-point trend, +100.0% 0.0 -0.7 -0.7 -0.8 -1.3 -6.2 · · · · · ·
Interest Coverage 9-point trend, +89.5% · · -1.0 -1.5 -3.0 -12.1 -8.4 -10.3 · -7.5 -7.6 -9.2
Efficienza 3
Dati annuali Efficienza per BCRX
Metrica Tendenza 202520242023202220212020201920182017201620152014
Asset Turnover 11-point trend, +1088.9% 1.7 0.9 0.6 0.5 0.3 0.1 0.3 0.1 · 0.2 0.4 0.1
Inventory Turnover 9-point trend, +97455.2% 2.8 0.4 0.2 0.3 0.6 0.4 · · · 2.2 1.2 0.0
Receivables Turnover 10-point trend, -1.6% 9.4 6.6 6.2 6.8 8.3 1.2 3.7 4.0 · 3.5 9.6 ·
Per Azione 5
Dati annuali Per Azione per BCRX
Metrica Tendenza 202520242023202220212020201920182017201620152014
Book Value / Share 11-point trend, -153.2% $-0.56 $-2.28 $-2.21 $-1.57 $-0.58 $-0.11 $0.25 $0.45 · $0.02 $0.65 $1.05
Revenue / Share 10-point trend, +504.6% $4.00 $2.18 $1.72 $1.46 $0.88 $0.11 $0.42 $0.20 · $0.36 $0.66 ·
Cash Flow / Share 10-point trend, +983.4% $1.59 $-0.25 $-0.49 $-0.87 $-0.79 $-0.82 $-0.77 $-0.90 · $-0.73 $-0.18 ·
Cash / Share 11-point trend, -44.4% $0.42 $0.50 $0.54 $1.62 $2.74 $1.54 $0.74 $0.24 · $0.30 $0.39 $0.76
EPS (TTM) 11-point trend, +301.7% $1.21 $-0.43 $-1.18 $-1.33 $-1.03 $-1.09 $-0.61 $-0.61 $-0.61 $-0.61 $-0.60 ·
Tassi di Crescita 3
Dati annuali Tassi di Crescita per BCRX
Metrica Tendenza 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, -88.0% 94.1% 36.0% 22.4% 72.3% 782.4% · · · · · · ·
Revenue CAGR 3Y 3-point trend, -71.0% 47.8% 42.1% 165.0% · · · · · · · · ·
Revenue CAGR 5Y 117.9% · · · · · · · · · · ·
Valutazione (TTM) 13
Dati annuali Valutazione (TTM) per BCRX
Metrica Tendenza 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +6328.8% $875M $451M $331M $271M $157M $18M $49M $21M $25M $26M $48M $14M
Net Income TTM 12-point trend, +683.9% $264M $-89M $-227M $-247M $-184M $-183M $-109M $-101M $-66M $-55M $-43M $-45M
Market Cap 11-point trend, +89.9% $1.66B $1.57B $1.23B $2.16B $2.55B $1.32B $532M $888M · $467M $757M $875M
Enterprise Value 11-point trend, +63.1% $1.39B $1.78B $1.43B $2.08B $2.18B $1.20B $447M $891M · $473M $758M $850M
P/E 11-point trend, +137.5% 6.4 -17.5 -5.1 -8.6 -13.4 -6.8 -5.7 -13.2 -8.0 -10.4 -17.2 ·
P/S 11-point trend, -97.0% 1.9 3.5 3.7 8.0 16.2 74.0 10.9 43.0 · 17.7 15.7 64.3
P/B 11-point trend, -220.6% -13.9 -3.3 -2.7 -7.3 -23.9 -68.4 13.9 18.0 · 296.0 15.9 11.6
P / Cash Flow 11-point trend, +121.1% 4.8 -30.1 -13.0 -13.3 -18.0 -9.6 -5.9 -9.6 · -8.7 -57.7 -22.7
P / FCF 11-point trend, +121.3% 4.8 -29.5 -12.7 -13.2 -17.7 -9.6 -5.9 -9.6 · -8.0 -41.5 -22.6
EV / EBITDA 11-point trend, +121.7% 4.1 -1371.2 -14.0 -14.2 -12.3 -6.9 -4.5 -9.5 · -9.8 -19.3 -18.7
EV / FCF 11-point trend, +118.3% 4.0 -33.5 -14.6 -12.8 -15.1 -8.7 -5.0 -9.6 · -8.1 -41.6 -22.0
EV / Revenue 11-point trend, -97.5% 1.6 3.9 4.3 7.7 13.9 67.1 9.2 43.1 · 18.0 15.7 62.5
Earnings Yield 11-point trend, +367.0% 15.5% -5.7% -19.7% -11.6% -7.4% -14.6% -17.7% -7.6% -12.4% -9.6% -5.8% ·

Bilanci Conto economico, stato patrimoniale, flusso di cassa — annuale, ultimi 5 anni

Conto Economico
2025-12-312024-12-312023-12-312022-12-312021-12-31
Ricavi $875M$451M$331M$271M$157M
Margine Operativo % 39.0%-0.56%-31.3%-54.8%-113.1%
Utile netto $264M$-89M$-227M$-247M$-184M
EPS Diluito $1.21$-0.43$-1.18$-1.33$-1.03
Stato Patrimoniale
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debito / Patrimonio Netto 0.0-0.7-0.7-0.8-1.3
Rapporto corrente 2.12.63.34.95.5
Quick Ratio 1.91.11.13.45.1
Flusso di cassa
2025-12-312024-12-312023-12-312022-12-312021-12-31
Flusso di cassa libero $345M$-53M$-97M$-163M$-145M

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Proprietari istituzionali (13F) 346 filer · $2.1B totale · Aggiornato al 30 Giugno 2026

Istituzioni che segnalano il possesso di questo titolo nel loro Modulo SEC 13F trimestrale. Solo posizioni lunghe; un singolo depositante può apparire due volte per diverse gambe di opzioni. Grandi posizioni put/call contrapposte riflettono tipicamente market-making o inventario coperto, non convinzione direzionale.

Attività istituzionale — Q2 2026 vs trimestre precedente
Nuove posizioni Posizioni chiuse Aumentato Diminuito Variazione netta delle azioni
63 (-7 vs trimestre precedente) 34 (-7 vs trimestre precedente) 130 (+19 vs trimestre precedente) 83 (+3 vs trimestre precedente) +25.9M

Confrontato con Q1 2026. Le dichiarazioni SEC Form 13F sono dovute entro 45 giorni dalla fine del trimestre più un breve margine per i dichiaranti in ritardo — i trimestri ancora all'interno di questa finestra vengono saltati a favore della coppia più recente completamente riportata.

Istituzione Valore Azioni % di 13F tracciati Tipo
RA CAPITAL MANAGEMENT, L.P. $158.271.860 15.827.186 7,51% Azioni
STATE STREET CORP $151.910.980 15.191.098 7,21% Azioni
DEERFIELD MANAGEMENT COMPANY, L.P. $150.964.030 15.096.403 7,16% Azioni
VANGUARD CAPITAL MANAGEMENT LLC $113.642.360 11.364.236 5,39% Azioni
VANGUARD PORTFOLIO MANAGEMENT LLC $111.391.580 11.139.158 5,29% Azioni
TCG Crossover Management, LLC $110.209.680 11.020.968 5,23% Azioni
PERCEPTIVE ADVISORS LLC $103.088.880 10.308.888 4,89% Azioni
JANUS HENDERSON GROUP PLC $83.961.589 8.814.865 3,98% Azioni
Vestal Point Capital, LP $83.000.000 8.300.000 3,94% Azioni
TWO SIGMA INVESTMENTS, LP $67.753.490 6.775.349 3,21% Azioni
GEODE CAPITAL MANAGEMENT, LLC $53.581.572 5.356.880 2,54% Azioni
Aberdeen Group plc $53.108.710 5.310.871 2,52% Azioni
Frazier Life Sciences Management, L.P. $40.092.400 4.009.240 1,90% Azioni
GOLDMAN SACHS GROUP INC $35.393.210 3.539.321 1,68% Azioni
MILLENNIUM MANAGEMENT LLC $33.947.290 3.394.729 1,61% Azioni
TWO SIGMA ADVISERS, LP $31.895.074 4.089.112 1,51% Azioni
RP Management, LLC $28.846.155 3.846.154 1,37% Azioni
DIMENSIONAL FUND ADVISORS LP $27.161.110 2.716.111 1,29% Azioni
Fisher Asset Management, LLC $26.040.270 2.604.027 1,24% Azioni
RENAISSANCE TECHNOLOGIES LLC $25.302.900 2.530.290 1,20% Azioni
Kynam Capital Management, LP $25.226.600 2.522.660 1,20% Azioni
Candriam S.C.A. $25.125.293 2.514.949 1,19% Azioni
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $23.532.910 2.353.291 1,12% Azioni
RICE HALL JAMES & ASSOCIATES, LLC $23.320.430 2.332.043 1,11% Azioni
AQR CAPITAL MANAGEMENT LLC $21.850.110 2.185.011 1,04% Azioni
Nantahala Capital Management, LLC $19.011.600 1.901.160 0,90% Azioni
Eversept Partners, LP $18.656.530 1.865.653 0,89% Azioni
ORBIMED ADVISORS LLC $18.520.000 1.852.000 0,88% Azioni
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND $18.449.120 1.844.912 0,88% Azioni
VANGUARD FIDUCIARY TRUST CO $17.595.730 1.759.573 0,83% Azioni
CITADEL ADVISORS LLC $17.591.600 1.759.160 0,83% Azioni
IMC-Chicago, LLC $16.343.360 1.634.336 0,78% Azioni
Parkman Healthcare Partners LLC $16.242.790 1.624.279 0,77% Azioni
JANE STREET GROUP, LLC $14.267.680 1.426.768 0,68% Azioni
OP Asset Management Ltd $13.409.900 1.340.990 0,64% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $11.956.510 1.195.651 0,57% Azioni
Pictet Asset Management Holding SA $11.951.392 1.249.771 0,57% Azioni
BNP PARIBAS FINANCIAL MARKETS $11.740.520 1.174.052 0,56% Azioni
FIRST TRUST ADVISORS LP $11.204.690 1.120.469 0,53% Azioni
JANE STREET GROUP, LLC $9.944.130 994.413 0,47% Opzione Call
Cubist Systematic Strategies, LLC $9.462.419 1.246.696 0,45% Azioni
MOORE CAPITAL MANAGEMENT, LP $8.483.360 848.336 0,40% Azioni
FMR LLC $8.062.330 806.233 0,38% Azioni
BANK OF AMERICA CORP /DE/ $7.754.020 775.402 0,37% Azioni
ExodusPoint Capital Management, LP $7.449.170 744.917 0,35% Azioni
Man Group plc $7.324.800 732.480 0,35% Azioni
Rosalind Advisors, Inc. $7.215.040 721.504 0,34% Azioni
Schonfeld Strategic Advisors LLC $7.108.160 710.816 0,34% Azioni
BlackRock, Inc. $5.984.400 598.440 0,28% Azioni
Elmind Capital, LP $5.200.000 520.000 0,25% Azioni
Bridgewater Associates, LP $4.910.570 491.057 0,23% Azioni
NAN FUNG TRINITY (HK) LTD $4.500.000 450.000 0,21% Azioni
SPHERA FUNDS MANAGEMENT LTD. $4.220.510 422.051 0,20% Azioni
Swiss National Bank $4.152.680 415.268 0,20% Azioni
Susquehanna Portfolio Strategies, LLC $4.047.040 404.704 0,19% Azioni
DAFNA Capital Management LLC $4.002.480 400.248 0,19% Azioni
Hudson Bay Capital Management LP $4.000.000 400.000 0,19% Azioni
Aquatic Capital Management LLC $3.628.950 362.895 0,17% Azioni
DOLIVER CAPITAL ADVISORS, INC. $3.563.603 374.328 0,17% Azioni
Assenagon Asset Management S.A. $3.530.440 353.044 0,17% Azioni
Kodai Capital Management LP $3.515.993 468.799 0,17% Azioni
MACKENZIE FINANCIAL CORP $3.472.990 347.299 0,16% Azioni
CITIGROUP INC $3.467.520 346.752 0,16% Azioni
Phocas Financial Corp. $3.405.410 340.541 0,16% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $3.238.000 323.800 0,15% Opzione Call
ALPS ADVISORS INC $3.179.600 317.960 0,15% Azioni
ALLIANCEBERNSTEIN L.P. $3.121.694 327.909 0,15% Azioni
RHUMBLINE ADVISERS $2.798.390 279.839 0,13% Azioni
Rafferty Asset Management, LLC $2.656.180 265.618 0,13% Azioni
Point72 Asset Management, L.P. $2.609.170 260.917 0,12% Azioni
Nuveen, LLC $2.599.030 259.903 0,12% Azioni
NFJ INVESTMENT GROUP, LLC $2.568.330 256.833 0,12% Azioni
Nebula Research & Development LLC $2.567.121 286.509 0,12% Azioni
WINTON GROUP Ltd $2.556.000 255.600 0,12% Azioni
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $2.459.444 258.345 0,12% Azioni
MARTINGALE ASSET MANAGEMENT L P $2.425.080 242.508 0,12% Azioni
WELLINGTON MANAGEMENT GROUP LLP $2.324.670 232.467 0,11% Azioni
CITADEL ADVISORS LLC $2.322.000 232.200 0,11% Opzione Call
IEQ CAPITAL, LLC $2.274.210 227.421 0,11% Azioni
Bank of New York Mellon Corp $2.251.670 225.167 0,11% Azioni
D. E. Shaw & Co., Inc. $2.249.120 224.912 0,11% Azioni
JUPITER ASSET MANAGEMENT LTD $2.221.030 222.103 0,11% Azioni
HUSSMAN STRATEGIC ADVISORS, INC. $2.100.000 210.000 0,10% Azioni
PFM Health Sciences, LP $2.073.570 207.357 0,10% Azioni
VANGUARD ASSET MANAGEMENT, Ltd $1.962.800 196.280 0,09% Azioni
TUDOR INVESTMENT CORP ET AL $1.951.280 195.128 0,09% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1.853.000 185.300 0,09% Opzione Put
VIRGINIA RETIREMENT SYSTEMS ET Al $1.820.161 233.354 0,09% Azioni
Engineers Gate Manager LP $1.750.020 175.002 0,08% Azioni
Squarepoint Ops LLC $1.747.140 174.714 0,08% Azioni
QTR Family Wealth, LLC $1.610.820 161.082 0,08% Azioni
Gotham Asset Management, LLC $1.564.210 156.421 0,07% Azioni
CITADEL ADVISORS LLC $1.450.000 145.000 0,07% Opzione Put
Corient Private Wealth LP $1.429.860 142.986 0,07% Azioni
NEW YORK STATE COMMON RETIREMENT FUND $1.386.570 138.657 0,07% Azioni
Quantinno Capital Management LP $1.374.530 137.453 0,07% Azioni
MetLife Investment Management, LLC $1.356.700 135.670 0,06% Azioni
PROFUND ADVISORS LLC $1.340.340 134.034 0,06% Azioni
Virtus Investment Advisers, LLC $1.336.640 133.664 0,06% Azioni
ADAR1 Capital Management, LLC $1.330.000 133.000 0,06% Azioni

Insider aziendali 51 insider · 21 dirigenti · 30 direttori

Insider Ruolo Ultima attività Azioni possedute Acquisti 12m Vendite 12m Netto 12m
Babar Ghias Chief Financial Officer 17 Dicembre 2025 A 268.700 0 0 $0
Anthony Doyle Chief Financial Officer 19 Dicembre 2024 A 377.867 0 0 $0
Thomas R Staab II Senior Vice President and CFO 21 Febbraio 2020 A 125.176 0 0 $0
Stuart Grant SR VP & CFO 16 Marzo 2011 M 57.102 0 0 $0
Charles K Gayer President and CCO 22 Dicembre 2025 M 952.583 0 0 $0
Claude J Bennett Chief Operating Officer 14 Marzo 2008 A 65.730 0 0 $0
Alane P Barnes Chief Legal Officer 13 Maggio 2026 M 400.703 0 7 $-3.461.969
Sandeep Menon Chief R&D Officer 06 Aprile 2026 A 205.150 0 0 $0
Helen M. Thackray Chief R&D Officer 31 Marzo 2025 F 377.318 0 0 $0
Michael L Jones Exec. Director, Finance - PAO 19 Dicembre 2022 A 16.653 0 0 $0
Yarlagadda S Babu Chief Discovery Officer 14 Novembre 2022 M 298.541 0 0 $0
William P Sheridan Chief Medical Officer 10 Marzo 2022 M 37.954 0 0 $0
Megan Sniecinski Chief Business Officer 15 Dicembre 2020 A 45.000 0 0 $0
Lynne Powell Senior VP - CCO 28 Gennaio 2019 M 0 0 0 $0
David Mccullough VP 15 Marzo 2012 F 24.124 0 0 $0
Robert S Lowrey Controller, PAO 07 Febbraio 2011 A 9.766 0 0 $0
Mike Mills Principal Accounting Officer 12 Marzo 2010 M 0 0 0 $0
Michael A Darwin Principal Accounting Officer 31 Luglio 2008 P 3.048 0 0 $0
Jonathan M Nugent VP Corp Communications 31 Luglio 2007 P 508 0 0 $0
James W Alexander SR. VP, Chief Medical Officer 31 Luglio 2007 P 3.659 0 0 $0
Randall B Riggs Senior VP Business Development 16 Maggio 2007 A 1.928 0 0 $0
Amy E Mckee Direttore 11 Giugno 2026 A 47.177 0 1 $-100.285
Theresa Heggie Direttore 11 Giugno 2026 A 80.646 0 1 $-504.823
Machelle Sanders Direttore 11 Giugno 2026 A 45.936 0 1 $-68.544
Jill C. Milne Direttore 11 Giugno 2026 A 31.938 0 0 $0
Steven Frank Direttore 11 Giugno 2026 A 35.459 0 0 $0
Steven K Galson Direttore 11 Giugno 2026 A 27.794 0 0 $0
Jon P Stonehouse Direttore 11 Giugno 2026 A 1.339.775 0 0 $0
Vincent Milano Direttore 11 Giugno 2026 A 108.483 0 0 $0
Alan G Levin Direttore 11 Giugno 2026 A 79.565 0 0 $0
Nancy J Hutson Direttore 12 Giugno 2025 A 99.138 0 0 $0
George B Abercrombie Direttore 12 Giugno 2024 A 36.431 0 0 $0
Steve Aselage Direttore 12 Giugno 2024 A 70.159 0 0 $0
Kenneth B Lee JR Direttore 13 Giugno 2023 A 68.863 0 0 $0
Robert Alexander Ingram Direttore 28 Febbraio 2023 A 100.198 0 0 $0
Stanley C Erck Direttore 28 Novembre 2018 M 48.333 0 0 $0
Fred Cohen Direttore 20 Giugno 2018 A 119.410 0 0 $0
Sanj K Patel Direttore 24 Maggio 2017 A 0 0 $0
Charles A Sanders Direttore 29 Febbraio 2016 A 12.971 0 0 $0
Peder Jensen Direttore 02 Maggio 2014 A 60.000 0 0 $0
John L Higgins Direttore 23 Maggio 2012 A 0 0 $0
HOROVITZ ZOLA P Direttore 23 Maggio 2012 A 3.000 0 0 $0
Stephen R Biggar Direttore 12 Maggio 2011 A 0 0 $0
Beth C Seidenberg Direttore 13 Maggio 2010 A 3.000 0 0 $0
William W Featheringill Direttore 13 Maggio 2010 A 231.538 0 0 $0
William M Spencer III Direttore 16 Maggio 2007 A 186.761 0 0 $0
Joseph H Sherrill JR Direttore 16 Maggio 2007 A 451.900 0 0 $0
Charles E Bugg Direttore 18 Marzo 2007 A 62.439 0 0 $0
GORDON CARL L Direttore 17 Maggio 2006 A 1.100.000 0 0 $0
John A Montgomery Direttore 04 Novembre 2003 M 46.785 0 0 $0

Insider dai depositi SEC Modulo 3/4/5; netto = solo acquisti/vendite di mercato

Attivisti e proprietari del 5%+ 15 partecipazioni

Investitori che hanno depositato SEC Schedule 13D — proprietà effettiva superiore al 5% con l'intento di influenzare l'emittente (partecipazioni attiviste, campagne per il consiglio di amministrazione, M&A). Ogni riga mostra lo stato più recente noto della posizione di quel depositante.

Depositante Depositato Partecipazione Stato Scopo Deposito
Great Point Partners, LLC, Dr. Jeffrey R. Jay, M.D., Mr. David Kroin ×3 depositi 31 Luglio 2018 Deposito iniziale SEC
RA Capital Management, LLC, Peter Kolchinsky, RA Capital Healthcare Fund, L.P. 02 Aprile 2018 Deposito iniziale Investimento passivo SEC
Baker Bros. Advisors LP, Baker Bros. Advisors (GP) LLC, Julian C. Baker, Felix J. Baker ×5 depositi 16 Agosto 2016 Deposito iniziale SEC
Baker Bros. Advisors, LLC, Julian C. Baker, Felix J. Baker ×2 depositi 23 Ottobre 2012 Deposito iniziale SEC
Julian C. Baker, Felix J. Baker ×4 depositi 13 Ottobre 2011 Deposito iniziale SEC
L. John Doerr III, KPCB Pandemic and Bio Defense Fund, LLC, KPTV, LLC ×2 depositi 20 Agosto 2007 Deposito iniziale SEC
Persona segnalante non divulgata, Persona segnalante non divulgata, Persona segnalante non divulgata 07 Dicembre 2005 Deposito iniziale SEC
Persona segnalante non divulgata, Persona segnalante non divulgata, Persona segnalante non divulgata 07 Dicembre 2005 Deposito iniziale SEC
Persona segnalante non divulgata, Persona segnalante non divulgata, Persona segnalante non divulgata 07 Dicembre 2005 Deposito iniziale SEC
Persona segnalante non divulgata 13 Ottobre 2005 Deposito iniziale SEC
Persona segnalante non divulgata, Persona segnalante non divulgata, Persona segnalante non divulgata 26 Febbraio 2004 Deposito iniziale SEC
Persona segnalante non divulgata, Persona segnalante non divulgata, Persona segnalante non divulgata 25 Febbraio 2004 Deposito iniziale SEC
Persona segnalante non divulgata, Persona segnalante non divulgata, Persona segnalante non divulgata 24 Febbraio 2004 Deposito iniziale SEC
Biotechnology Value Fund, L.P., Investment 10, L.L.C., Biotechnology Value Fund II, L.P., BVF Investments, L.L.C., BVF Partners L.P., BVF Inc. ×2 depositi 31 Ottobre 2003 Deposito iniziale SEC
William W. Featheringill 14 Febbraio 2002 Deposito iniziale SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Proprietà ETF Posseduti da 53 ETF

Il peso riflette solo le partecipazioni azionarie dirette (N-PORT); fondi a leva o basati su derivati possono detenere ulteriore esposizione swap non mostrata.

Fondo Peso Unità Aggiornato al Fonte
PBE · Invesco Exchange-Traded Fund Trust 2,65% 1.023.838 SH 08 Agosto 2026 Giornaliero
BBP · ETFis Series Trust I 1,93% 125.015 NS 30 Aprile 2026 N-PORT
ABLS · Abacus FCF ETF Trust 1,26% 1.682 NS 30 Aprile 2026 N-PORT
LABU · Direxion Shares ETF Trust 0,67% 381.305 NS 30 Aprile 2026 N-PORT
FYC · First Trust Exchange-Traded AlphaDE… 0,54% 612.341 NS 30 Aprile 2026 N-PORT
CALF · Pacer Funds Trust 0,41% 1.556.494 NS 30 Aprile 2026 N-PORT
FYX · First Trust Exchange-Traded AlphaDE… 0,28% 364.624 NS 30 Aprile 2026 N-PORT
BFOR · ALPS ETF Trust 0,25% 59.894 NS 31 Maggio 2026 N-PORT
OMFS · Invesco Exchange-Traded Self-Indexe… 0,24% 72.535 SH 08 Agosto 2026 Giornaliero
GSSC · Goldman Sachs ETF Trust 0,19% 213.133 NS 31 Maggio 2026 N-PORT
SMLF · iShares Trust 0,17% 758.958 SH 08 Agosto 2026 Giornaliero
IBBQ · Invesco Exchange-Traded Fund Trust … 0,16% 13.830 SH 08 Agosto 2026 Giornaliero
IBB · iShares Trust 0,15% 1.580.105 SH 08 Agosto 2026 Giornaliero
ESSC · Strategy Shares 0,15% 4.183 NS 30 Aprile 2026 N-PORT
VTWG · VANGUARD SCOTTSDALE FUNDS 0,14% 249.665 SH 08 Agosto 2026 Giornaliero
IWO · iShares Trust 0,13% 2.097.061 SH 08 Agosto 2026 Giornaliero
BIB · ProShares Trust 0,11% 9.271 NS 31 Maggio 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0,11% 57.134 NS 30 Aprile 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0,10% 81.871 NS 30 Aprile 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0,07% 1.339.774 SH 08 Agosto 2026 Giornaliero
ISCG · iShares Trust 0,07% 73.787 SH 08 Agosto 2026 Giornaliero
IWM · iShares Trust 0,07% 5.925.076 SH 08 Agosto 2026 Giornaliero
PRFZ · Invesco Exchange-Traded Fund Trust 0,07% 206.325 SH 08 Agosto 2026 Giornaliero
RSSL · Global X Funds 0,06% 97.958 NS 30 Aprile 2026 N-PORT
DFAS · Dimensional ETF Trust 0,05% 806.097 NS 30 Aprile 2026 N-PORT
ITWO · ProShares Trust 0,05% 10.652 NS 31 Maggio 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0,05% 1.154.262 NS 31 Maggio 2026 N-PORT
VBK · VANGUARD INDEX FUNDS 0,04% 1.696.014 SH 08 Agosto 2026 Giornaliero
ISCB · iShares Trust 0,03% 10.494 SH 08 Agosto 2026 Giornaliero
FHLC · FIDELITY COVINGTON TRUST 0,03% 96.151 NS 30 Aprile 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0,03% 2.837.341 SH 08 Agosto 2026 Giornaliero
VHT · VANGUARD WORLD FUND 0,03% 624.412 SH 08 Agosto 2026 Giornaliero
UWM · ProShares Trust 0,03% 8.331 NS 31 Maggio 2026 N-PORT
URTY · ProShares Trust 0,02% 8.425 NS 31 Maggio 2026 N-PORT
VB · VANGUARD INDEX FUNDS 0,02% 2.922.024 SH 08 Agosto 2026 Giornaliero
WSML · iShares Trust 0,02% 11.689 SH 08 Agosto 2026 Giornaliero
MSSM · MORGAN STANLEY PATHWAY FUNDS 0,01% 9.529 NS 31 Maggio 2026 N-PORT
HDG · ProShares Trust 0,01% 212 NS 31 Maggio 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0,01% 80.493 NS 31 Maggio 2026 N-PORT
DFUS · Dimensional ETF Trust 0,00% 74.317 NS 30 Aprile 2026 N-PORT
IWV · iShares Trust 0,00% 72.218 SH 08 Agosto 2026 Giornaliero
AVUQ · AMERICAN CENTURY ETF TRUST 0,00% 937 NS 31 Maggio 2026 N-PORT
ITOT · iShares Trust 0,00% 336.352 SH 08 Agosto 2026 Giornaliero
SCHB · SCHWAB STRATEGIC TRUST 0,00% 141.645 NS 31 Maggio 2026 N-PORT
TILT · FlexShares Trust 0,00% 6.314 NS 30 Aprile 2026 N-PORT
DFAC · Dimensional ETF Trust 0,00% 34.873 NS 30 Aprile 2026 N-PORT
DFAT · Dimensional ETF Trust 0,00% 8.956 NS 30 Aprile 2026 N-PORT
FSCC · Federated Hermes ETF Trust 0,00% 129 NS 31 Maggio 2026 N-PORT
DFAU · Dimensional ETF Trust 0,00% 3.019 NS 30 Aprile 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0,00% 8.070.274 SH 08 Agosto 2026 Giornaliero