CRNX Crinetics Pharmaceuticals, Inc. - Common Stock

NASDAQ · Pharmaceuticals · Visualizza su SEC EDGAR ↗
$84,77
Prezzo · Ago 19, 2026
Fondamentali al Ago 3, 2026

Informazioni su Crinetics Pharmaceuticals, Inc. - Common Stock Panoramica della società da Wikipedia

Crinetics Pharmaceuticals is a global pharmaceutical company known for developing drugs for the treatment of endocrine-related diseases. It was founded by Scott Struthers, Frank Zhu, Ana Kusnetzow, and Stephen F. Betz in 2008 and is headquartered in San Diego, California. It went public on NASDAQ in 2018.

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Crinetics Pharmaceuticals is a global pharmaceutical company known for developing drugs for the treatment of endocrine-related diseases. It was founded by Scott Struthers, Frank Zhu, Ana Kusnetzow, and Stephen F. Betz in 2008 and is headquartered in San Diego, California. It went public on NASDAQ in 2018.

In July 2026, Vertex Pharmaceuticals agreed to acquire the company for $10 billion.

History

Struthers, Zhu, Kusnetzow, and Betz founded Crinetics in 2008 after previously working together on a small molecule drug for the treatment of endometriosis at Neurocrine Biosciences.

Crinetics expanded into a larger laboratory in 2010. After receiving NIH grant funding, Crinetics moved into its second laboratory.

In 2011, Crinetics Pharmaceuticals competed for the Michelson Prize, a competition sponsored by the Found Animals Foundation to develop a low-cost, non-surgical method for sterilizing dogs and cats, which would later lead to the licensing of a molecule for the treatment of acromegaly in large breed dogs.

Crinetics first synthesized its lead drug candidate to treat acromegaly. The drug was named paltusotine, in 2016. Crinetics Pharmaceuticals went public with an IPO in 2018. It conducted Phase II trials for paltusotine from 2019 to 2020. It conducted Phase III trials for paltusotine from 2021 to 2024. After the drug succeeded in a second Phase III study, the FDA accepted the company's new drug application for paltusotine and the company announced it was planning for a 2025 launch for the drug. The FDA set a Prescription Drug User Fee Act for the drug on September 25, 2025.

In 2021, Crinetics, together with 5AM Ventures and Frazier Healthcare Partners, formed an independently operated new company, Radionetics Oncology, aimed to develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range of oncology indications.

Crinetics partnered with the veterinary medicine company Loyal to develop a pill to extend the lifespans of large dogs in 2023.

In 2024, Scott Struthers received the Ernst & Young Entrepreneur of the Year Award for his work with Crinetics. In 2024, Crinetics was reported to have patent activity in rare diseases, health technology, and addiction therapies.

In 2024, Radionetics formed a strategic relationship with Eli Lilly and Company to take forward Radionetics’ proprietary GPCR targeting small molecule radiopharmaceuticals. Under the terms of the agreement, Radionetics received a $140 million upfront cash payment. As part of the strategic agreement, Lilly obtained the exclusive right to acquire Radionetics upon conclusion of an exercise period for $1 billion.

Crinetics also established its first office outside the United States in Zug, Switzerland in 2024.

In 2025, Crinetics Pharmaceuticals plans to file an Investigational New Drug for an oral thyroid stimulating hormone receptor antagonist and its nonpeptide drug conjugate (CRN09682). A total of four development candidates are currently in IND-enabling studies, including a PTH antagonist (Hyperparathyrodism), non-peptide drug conjugate (NETs and SST2-expressing solid tumors), TSH antagonist (Graves’ disease & TED) and SST3 agonist (ADPKD).

In July 2026, Vertex Pharmaceuticals agreed to acquire Crinetics for $10 billion.

Treatments

Crinetics’ pipeline focuses on synthesizing novel molecules for rare endocrine diseases. It is most known for developing paltusotine, a drug designed to treat the hormonal disorder acromegaly. Paltusotine works by helping moderate elevated IGF-1 levels, which is the main symptom of acromegaly. Paltusotine has also been tested as a treatment for carcinoid syndrome.

Crinetics has also developed oral treatments for neuroendocrine tumors, hyperinsulism, and Cushing's disease. The company's drug for treating Cushing's disease, Atumeltnant (also known as CRN049894), works by reducing levels of ACTH.

The company's pipeline also includes an oral parathyroid hormone inhibitor program for hyperparathyroidism and treatments for thyroid eye disease, Graves' disease, and obesity. Additionally, Crinetics nonpeptide drug conjugates (NDCs) include CRN09682, which is a somatostatin receptor 2 (SST2) targeted drug. NDCs are a new technology developed in-house by Crinetics.

== References ==

Fonte: Wikipedia (Inglese), CC BY-SA 4.0 · Vedi su Wikipedia ↗

Wikidata ↗

CRNX Snapshot del titolo Prezzo, capitalizzazione di mercato, P/E, EPS, ROE, debito/capitale proprio, intervallo 52 settimane

Prezzo
$84.77
Capitalizzazione di Mercato
$8.10B
P/E (TTM)
-17.1
EPS (TTM)
$-4.95
Ricavi (TTM)
$8M
Rendimento div.
ROE
-43.0%
D/E Debito/Patrimonio
Intervallo 52 sett.
$29 – $85

CRNX Grafico del prezzo delle azioni OHLCV giornaliero con indicatori tecnici — panoramica, zoom e personalizza la tua visualizzazione

Performance decennale Andamento di ricavi, utile netto, margini e EPS

Ricavi e Utile Netto $8M
10-point trend, +1206.6%
2016-12-31 2025-12-31
EPS $-4.95
6-point trend, -104.5%
2020-12-31 2025-12-31
Flusso di cassa libero $-384M
8-point trend, -1770.0%
2018-12-31 2025-12-31
Margini -6046.2%

Valutazione Rapporti P/E, P/S, P/B, EV/EBITDA — il titolo è costoso o economico?

Metrica
Tendenza 5 anni
CRNX
Mediana dei peer
P/E (TTM)
5-point trend, +7.3%
-17.1
47.9
P/S (TTM)
5-point trend, -53.9%
1052.7
16.2
P/B
5-point trend, +10.1%
8.2
9.3
Price / FCF (Prezzo / FCF)
5-point trend, +23.7%
-21.1

Redditività Margini lordi, operativi e netti; ROE, ROA, ROIC

Metrica
Tendenza 5 anni
CRNX
Mediana dei peer
Operating Margin (Margine Operativo)
5-point trend, +32.8%
-6714.8%
Net Profit Margin (Margine di Profitto Netto)
5-point trend, +39.4%
-6046.2%
5.1%
ROA
5-point trend, +9.8%
-36.3%
0.81%
ROE
5-point trend, -5.0%
-43.0%
-15.3%
ROIC
5-point trend, -60.6%
-52.1%

Salute finanziaria Debito, liquidità, solvibilità — solidità del bilancio

Metrica
Tendenza 5 anni
CRNX
Mediana dei peer
Current Ratio (Rapporto corrente)
5-point trend, -42.8%
12.3
2.7
Quick Ratio
5-point trend, -42.1%
12.1

Crescita Crescita di ricavi, EPS e utile netto: YoY, CAGR 3Y, CAGR 5Y

Metrica
Tendenza 5 anni
CRNX
Mediana dei peer
Revenue YoY (Ricavi YoY)
5-point trend, +613.9%
640.7%
Revenue CAGR 3Y (CAGR Ricavi 3Y)
5-point trend, +613.9%
17.6%
Revenue CAGR 5Y (CAGR Ricavi 5Y)
5-point trend, +613.9%
155.3%

Metriche per Azione EPS, valore contabile per azione, flusso di cassa per azione, dividendo per azione

Metrica
Tendenza 5 anni
CRNX
Mediana dei peer
EPS (Diluted) (EPS (Diluito))
5-point trend, -76.8%
$-4.95

Efficienza del Capitale Rotazione delle attività, rotazione delle scorte, rotazione dei crediti

Metrica
Tendenza 5 anni
CRNX
Mediana dei peer

CRNX Consenso degli analisti Opinioni degli analisti, sia rialziste che ribassiste, target price a 12 mesi, potenziale di rialzo

MANTIENI 21 analisti
  • Acquisto forte 3 14,3%
  • Compra 4 19,0%
  • Mantieni 14 66,7%
  • Vendi 0 0,0%
  • Vendita forte 0 0,0%

Target Price a 12 Mesi

10 analisti · 2026-08-13
Target mediano $85.00 +0,3%
Target medio $85.50 +0,9%

Cronologia utili EPS effettivo vs stima, surprise %, tasso di superamento, data prossimi utili

Sorpresa media
-0.01%
Periodo EPS Actual EPS Stimato Sorpresa
30 Giugno 2026 $-1.14 $-1.23 0.09%
31 Marzo 2026 $-1.23 $-1.26 0.03%
31 Dicembre 2025 $-1.29 $-1.39 0.10%
30 Settembre 2025 $-1.38 $-1.28 -0.10%
30 Giugno 2025 $-1.23 $-1.12 -0.11%
31 Marzo 2025 $-1.04 $-0.96 -0.08%

Confronto Peer (GICS sub-settore industriale) Metriche chiave rispetto ai pari del settore

Ticker Capitalizzazione di Mercato P/E Rev YoY Margine Netto ROE Margine lordo
CRNX $4.45B -9.4 640.7% -6046.2% -43.0%
CORT $3.69B 42.4 12.8% 13.1% 15.5%
ELAN $11.25B -48.1 6.2% -4.9% -3.5% 55.0%
AXSM $9.29B -49.6 65.5% -28.7% -227.0%
LQDA $3.01B -43.1 1031.2% -43.5% -230.0%
BLTE
DFTX $1.32B -6.5 212.0% -71.0%
LGND $3.74B 30.8 60.4% 46.4% 13.5%
AMRX 57.3 8.1% 2.4% -80.0% 36.9%
LLY 46.8 44.7% 31.7% 101.2%

Fondamentali Completi Tutte le metriche per anno — conto economico, stato patrimoniale, rendiconto finanziario

Conto Economico 17
Dati annuali Conto Economico per CRNX
Metrica Tendenza 202520242023202220212020201920182017
Revenue 9-point trend, +276.3% $8M $1M $4M $5M $1M $71.0K $1M $2M $2M
Cost of Revenue 3-point trend, +1076000.00 $1M $0 $0 · · · · · ·
R&D Expense 9-point trend, +3496.4% $332M $240M $169M $130M $84M $57M $42M $24M $9M
SG&A Expense 9-point trend, +9767.5% $191M $100M $58M $42M $25M $18M $14M $7M $2M
Operating Expenses 9-point trend, +4594.5% $524M $340M $227M $173M $109M $75M $55M $31M $11M
Operating Income 9-point trend, -5562.0% $-517M $-339M $-223M $-168M $-108M $-75M $-54M $-29M $-9M
Interest Expense · · · · · · · · $8.0K
Interest Income 9-point trend, +199857.7% $52M $41M $13M $4M $157.0K $991.0K $3M $2M $26.0K
Other Non-op 9-point trend, -1090.0% $-357.0K $-519.0K $-159.0K $5M $61.0K $1M $3M $2M $-30.0K
Pretax Income 9-point trend, -4979.6% $-465M $-298M $-209M $-164M $-108M $-74M $-50M $-27M $-9M
Income Tax 9-point trend, +180000.00 $180.0K $0 $0 $0 $0 $0 $0 $0 $0
Net Income 9-point trend, -4981.5% $-465M $-298M $-215M $-164M $-108M $-74M $-50M $-27M $-9M
EPS (Basic) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
EPS (Diluted) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
Shares (Basic) 6-point trend, +208.9% 94,057,000 80,783,000 58,071,000 51,982,000 38,436,000 30,448,000 · · ·
Shares (Diluted) 6-point trend, +208.9% 94,057,000 80,783,000 58,071,000 51,982,000 38,436,000 30,448,000 · · ·
EBITDA 8-point trend, -1686.4% $-513M $-339M $-223M $-168M $-108M $-75M $-54M $-29M ·
Stato Patrimoniale 24
Dati annuali Stato Patrimoniale per CRNX
Metrica Tendenza 202520242023202220212020201920182017
Cash & Equivalents 9-point trend, +615.4% $102M $265M $55M $33M $201M $93M $40M $45M $14M
Short-term Investments 8-point trend, +679.1% $926M $1.09B $504M $302M $133M $78M $78M $119M ·
Receivables 2-point trend, +592000.00 $592.0K $0 · · · · · · ·
Inventory 2-point trend, +2022000.00 $2M $0 · · · · · · ·
Prepaid Expense 9-point trend, +1733.4% $18M $21M $16M $11M $11M $7M $5M $3M $973.0K
Other Current Assets 9-point trend, +1346.0% $3M $2M $448.0K $2M $912.0K $1M $668.0K $876.0K $239.0K
Current Assets 9-point trend, +6812.9% $1.05B $1.38B $574M $345M $345M $177M $123M $167M $15M
PP&E (Net) 9-point trend, +3474.0% $14M $12M $11M $4M $3M $3M $4M $4M $400.0K
PP&E (Gross) 9-point trend, +3060.2% $22M $20M $16M $8M $6M $6M $6M $5M $704.0K
Accum. Depreciation 9-point trend, +2515.8% $8M $8M $5M $4M $3M $3M $2M $741.0K $304.0K
Other Non-current Assets 7-point trend, +8472.7% · $3M $2M $37.0K $0 $40.0K $82.0K · $33.0K
Total Assets 9-point trend, +7120.5% $1.13B $1.43B $635M $352M $351M $183M $130M $171M $16M
Accounts Payable 9-point trend, +5510.7% $23M $6M $7M $7M $3M $6M $5M $5M $403.0K
Accrued Liabilities 2-point trend, +2240.8% · · · · · · · $4M $179.0K
Current Liabilities 9-point trend, +9384.1% $85M $60M $44M $28M $16M $10M $8M $8M $897.0K
Capital Leases 7-point trend, +767.2% $42M $45M $48M $2M $3M $4M $5M · ·
Other Non-current Liabilities 3-point trend, +3240000.00 $3M $829.0K $0 · · · · · ·
Total Liabilities 9-point trend, +14484.1% $134M $110M $96M $36M $19M $15M $13M $11M $920.0K
Common Stock 4-point trend, +25200.0% · · $253.0K $0 · · · $24.0K $1.0K
Retained Earnings 9-point trend, -8614.6% $-1.42B $-952M $-654M $-439M $-275M $-168M $-94M $-43M $-16M
AOCI 8-point trend, +2957.4% $2M $963.0K $977.0K $-4M $-382.0K $25.0K $148.0K $61.0K ·
Stockholders' Equity 9-point trend, +6704.2% $992M $1.32B $539M $316M $332M $169M $117M $160M $-15M
Liabilities + Equity 9-point trend, +7120.5% $1.13B $1.43B $635M $352M $351M $183M $130M $171M $16M
Shares Outstanding 9-point trend, +6067.8% 95,575,000 92,926,000 68,175,000 53,877,000 47,597,000 33,001,000 24,263,000 24,061 1,549,575
Flusso di cassa 13
Dati annuali Flusso di cassa per CRNX
Metrica Tendenza 202520242023202220212020201920182017
D&A 9-point trend, +2946.9% $4M $3M $1M $983.0K $922.0K $948.0K $887.0K $471.0K $128.0K
Stock-based Comp 9-point trend, +33488.2% $91M $69M $41M $28M $17M $10M $6M $2M $271.0K
Deferred Tax Flat — no change across 3 periods $0 $0 $0 · · · · · ·
Other Non-cash $-8M · · · · · · · ·
Operating Cash Flow 9-point trend, -3886.9% $-378M $-230M $-169M $-115M $-89M $-62M $-46M $-19M $-9M
CapEx 9-point trend, +1795.4% $6M $4M $5M $2M $436.0K $186.0K $492.0K $1M $304.0K
Investing Cash Flow 9-point trend, +57306.6% $174M $-575M $-200M $-174M $-56M $217.0K $42M $-119M $-304.0K
Stock Issued 7-point trend, -100.0% $0 $985M $370M $117M $250M $114M · $106M ·
Net Stock Activity 6-point trend, -100.0% $0 $970M $369M $117M $250M $114M · · ·
Financing Cash Flow 9-point trend, +243.5% $41M $1.01B $391M $122M $253M $115M $67.0K $170M $12M
Net Change in Cash 8-point trend, +10176.9% · $210M $22M $-167M $108M $53M $-5M $31M $2M
Taxes Paid 3-point trend, +89000.00 $89.0K $0 $0 · · · · · ·
Free Cash Flow 8-point trend, -1770.0% $-384M $-230M $-171M $-117M $-89M $-62M $-47M $-21M ·
Redditività 7
Dati annuali Redditività per CRNX
Metrica Tendenza 202520242023202220212020201920182017
Operating Margin 8-point trend, -467.9% -6714.8% -32613.5% -5547.2% -3544.1% -9990.9% -105567.6% -4512.3% -1182.5% ·
Net Margin 8-point trend, -441.4% -6046.2% -28720.7% -5345.9% -3460.4% -9985.2% -103960.6% -4226.5% -1116.8% ·
Pretax Margin 8-point trend, -441.2% -6043.9% -28720.7% -5345.9% -3460.4% -9985.2% -103960.6% -4226.5% -1116.8% ·
EBITDA Margin 8-point trend, -463.6% -6664.1% -32613.5% -5547.2% -3544.1% -9990.9% -105567.6% -4512.3% -1182.5% ·
ROA 8-point trend, -25.3% -36.3% -28.8% -43.5% -46.6% -40.3% -47.0% -33.4% -29.0% ·
ROE 8-point trend, -159.9% -43.0% -27.7% -39.5% -49.1% -41.0% -41.4% -40.9% -16.6% ·
ROIC 8-point trend, -190.8% -52.1% -25.6% -41.3% -53.1% -32.5% -44.4% -46.0% -17.9% ·
Liquidità e Solvibilità 2
Dati annuali Liquidità e Solvibilità per CRNX
Metrica Tendenza 202520242023202220212020201920182017
Current Ratio 8-point trend, -41.4% 12.3 23.0 13.1 12.5 21.6 16.9 14.8 21.0 ·
Quick Ratio 8-point trend, -41.5% 12.1 22.7 12.7 12.1 20.9 16.3 14.2 20.7 ·
Efficienza 3
Dati annuali Efficienza per CRNX
Metrica Tendenza 202520242023202220212020201920182017
Asset Turnover 8-point trend, -76.9% 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ·
Inventory Turnover 1.1 · · · · · · · ·
Receivables Turnover 26.0 · · · · · · · ·
Per Azione 5
Dati annuali Per Azione per CRNX
Metrica Tendenza 202520242023202220212020201920182017
Book Value / Share 8-point trend, +55.9% $10.38 $14.26 $7.91 $5.87 $6.97 $5.12 $4827.89 $6.66 ·
Revenue / Share 4-point trend, -10.2% $0.08 $0.01 $0.07 $0.09 · · · · ·
Cash Flow / Share 4-point trend, -81.3% $-4.02 $-2.80 $-2.86 $-2.22 · · · · ·
Cash / Share 8-point trend, -43.2% $1.06 $2.85 $0.81 $0.61 $4.22 $2.82 $1662.04 $1.87 ·
EPS (TTM) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
Tassi di Crescita 3
Dati annuali Tassi di Crescita per CRNX
Metrica Tendenza 202520242023202220212020201920182017
Revenue YoY 5-point trend, -54.8% 640.7% -74.1% -15.3% 339.4% 1418.3% · · · ·
Revenue CAGR 3Y 3-point trend, -93.8% 17.6% -1.2% 283.8% · · · · · ·
Revenue CAGR 5Y 155.3% · · · · · · · ·
Valutazione (TTM) 10
Dati annuali Valutazione (TTM) per CRNX
Metrica Tendenza 202520242023202220212020201920182017
Revenue TTM 8-point trend, +217.0% $8M $1M $4M $5M $1M $71.0K $1M $2M ·
Net Income TTM 8-point trend, -1616.1% $-465M $-298M $-215M $-164M $-108M $-74M $-50M $-27M ·
Market Cap 8-point trend, +516.6% $4.45B $4.75B $2.43B $986M $1.35B $466M $608.8K $722M ·
P/E 6-point trend, -61.3% -9.4 -13.9 -9.6 -5.8 -10.1 -5.8 · · ·
P/S 8-point trend, +94.5% 578.1 4573.0 604.5 208.1 1254.4 6558.4 0.5 297.2 ·
P/B 8-point trend, -0.4% 4.5 3.6 4.5 3.1 4.1 2.8 0.0 4.5 ·
P / Tangible Book 6-point trend, +62.7% 4.5 3.6 4.5 3.1 4.1 2.8 · · ·
P / Cash Flow 8-point trend, +68.3% -11.8 -21.0 -14.6 -8.6 -15.3 -7.5 -0.0 -37.1 ·
P / FCF 8-point trend, +67.0% -11.6 -20.7 -14.2 -8.4 -15.2 -7.5 -0.0 -35.2 ·
Earnings Yield 6-point trend, +38.0% -10.6% -7.2% -10.4% -17.2% -9.9% -17.2% · · ·

Bilanci Conto economico, stato patrimoniale, flusso di cassa — annuale, ultimi 5 anni

Conto Economico
2025-12-312024-12-312023-12-312022-12-312021-12-31
Ricavi $8M$1M$4M$5M$1M
Margine Operativo % -6714.8%-32613.5%-5547.2%-3544.1%-9990.9%
Utile netto $-465M$-298M$-215M$-164M$-108M
EPS Diluito $-4.95$-3.69$-3.69$-3.15$-2.80
Stato Patrimoniale
2025-12-312024-12-312023-12-312022-12-312021-12-31
Rapporto corrente 12.323.013.112.521.6
Quick Ratio 12.122.712.712.120.9
Flusso di cassa
2025-12-312024-12-312023-12-312022-12-312021-12-31
Flusso di cassa libero $-384M$-230M$-171M$-117M$-89M

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Proprietari istituzionali (13F) 286 filer · $3.2B totale · Aggiornato al 30 Giugno 2026

Istituzioni che segnalano il possesso di questo titolo nel loro Modulo SEC 13F trimestrale. Solo posizioni lunghe; un singolo depositante può apparire due volte per diverse gambe di opzioni. Grandi posizioni put/call contrapposte riflettono tipicamente market-making o inventario coperto, non convinzione direzionale.

Attività istituzionale — Q2 2026 vs trimestre precedente
Nuove posizioni Posizioni chiuse Aumentato Diminuito Variazione netta delle azioni
63 (+17 vs trimestre precedente) 30 (-14 vs trimestre precedente) 95 (-17 vs trimestre precedente) 63 (+3 vs trimestre precedente) +21.6M

Confrontato con Q1 2026. Le dichiarazioni SEC Form 13F sono dovute entro 45 giorni dalla fine del trimestre più un breve margine per i dichiaranti in ritardo — i trimestri ancora all'interno di questa finestra vengono saltati a favore della coppia più recente completamente riportata.

Istituzione Valore Azioni % di 13F tracciati Tipo
FMR LLC $486.250.673 12.994.406 15,13% Azioni
FARALLON CAPITAL MANAGEMENT, L.L.C. $336.372.047 8.989.098 10,46% Azioni
Driehaus Capital Management LLC $241.866.078 6.463.551 7,52% Azioni
WELLINGTON MANAGEMENT GROUP LLP $237.002.526 6.333.579 7,37% Azioni
VANGUARD PORTFOLIO MANAGEMENT LLC $180.836.416 4.832.614 5,63% Azioni
VANGUARD CAPITAL MANAGEMENT LLC $177.567.704 4.745.262 5,52% Azioni
STATE STREET CORP $100.635.477 2.689.350 3,13% Azioni
Bellevue Group AG $98.040.400 2.620.000 3,05% Azioni
BAKER BROS. ADVISORS LP $87.991.820 2.351.465 2,74% Azioni
GEODE CAPITAL MANAGEMENT, LLC $87.542.675 2.338.905 2,72% Azioni
Polar Capital Holdings Plc $85.108.460 2.274.411 2,65% Azioni
Pictet Asset Management Holding SA $77.572.984 2.075.375 2,41% Azioni
Siren, L.L.C. $53.165.887 1.420.788 1,65% Azioni
First Light Asset Management, LLC $50.923.606 1.360.866 1,58% Azioni
NOVO HOLDINGS A/S $49.394.400 1.320.000 1,54% Azioni
AMERICAN CENTURY COMPANIES INC $47.245.129 1.262.562 1,47% Azioni
ADAR1 Capital Management, LLC $45.730.234 1.222.080 1,42% Azioni
DIMENSIONAL FUND ADVISORS LP $44.555.208 1.190.679 1,39% Azioni
MONTANOVA CAPITAL, LLC $44.390.560 1.186.279 1,38% Azioni
ORBIMED ADVISORS LLC $37.382.580 999.000 1,16% Azioni
Hood River Capital Management LLC $36.259.830 968.996 1,13% Azioni
GOLDMAN SACHS GROUP INC $34.657.132 926.166 1,08% Azioni
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $32.841.401 877.643 1,02% Azioni
Aberdeen Group plc $30.699.181 820.395 0,95% Azioni
Candriam S.C.A. $30.618.690 819.032 0,95% Azioni
VANGUARD FIDUCIARY TRUST CO $28.230.995 754.436 0,88% Azioni
Fisher Asset Management, LLC $27.748.912 741.553 0,86% Azioni
SCHRODER INVESTMENT MANAGEMENT GROUP $17.709.036 479.400 0,55% Azioni
AMERIPRISE FINANCIAL INC $17.451.149 466.356 0,54% Azioni
Impax Asset Management Group plc $16.277.700 435.000 0,51% Azioni
Prosight Management, LP $14.020.002 374.666 0,44% Azioni
Universal- Beteiligungs- und Servicegesellschaft mbH $13.991.714 373.910 0,44% Azioni
KENNEDY CAPITAL MANAGEMENT LLC $13.685.018 365.714 0,43% Azioni
BRAUN STACEY ASSOCIATES INC $13.027.511 348.143 0,41% Azioni
Fiera Capital Corp $12.395.263 331.247 0,39% Azioni
BANK OF AMERICA CORP /DE/ $11.271.877 301.226 0,35% Azioni
Defilade Capital Management, L.P. $8.959.845 239.440 0,28% Azioni
SEB Asset Management AB $8.003.786 213.891 0,25% Azioni
Foresite Capital Management VI LLC $7.933.414 212.010 0,25% Azioni
RICE HALL JAMES & ASSOCIATES, LLC $7.346.220 196.318 0,23% Azioni
TD Asset Management Inc $7.152.534 191.142 0,22% Azioni
Swiss National Bank $6.877.796 183.800 0,21% Azioni
SEGALL BRYANT & HAMILL, LLC $6.855.307 183.199 0,21% Azioni
BlackRock, Inc. $6.781.290 181.221 0,21% Azioni
JENNISON ASSOCIATES LLC $6.056.839 161.861 0,19% Azioni
New Leaf Venture Partners, L.L.C. $5.872.650 141.000 0,18% Azioni
SILVERCREST ASSET MANAGEMENT GROUP LLC $5.865.136 156.738 0,18% Azioni
Foresite Capital Management IV, LLC $5.613.000 150.000 0,17% Azioni
Bank of New York Mellon Corp $5.581.754 149.165 0,17% Azioni
NEW YORK STATE COMMON RETIREMENT FUND $5.508.898 147.218 0,17% Azioni
ENVESTNET ASSET MANAGEMENT INC $5.471.384 146.216 0,17% Azioni
Moody Aldrich Partners LLC $5.466.201 146.077 0,17% Azioni
Ishara Investments LP $5.369.770 143.500 0,17% Azioni
CITADEL ADVISORS LLC $5.176.271 138.329 0,16% Azioni
RHUMBLINE ADVISERS $4.861.141 129.908 0,15% Azioni
ALLIANCEBERNSTEIN L.P. $4.782.618 131.680 0,15% Azioni
GordonMD Global Investments LP $4.751.779 126.985 0,15% Azioni
MANUFACTURERS LIFE INSURANCE COMPANY, THE $4.712.974 125.948 0,15% Azioni
JANUS HENDERSON GROUP PLC $4.700.428 129.392 0,15% Azioni
Cormorant Asset Management, LP $4.677.500 125.000 0,15% Azioni
SECTOR GAMMA AS $4.289.380 114.628 0,13% Azioni
XTX Topco Ltd $4.164.547 111.292 0,13% Azioni
ALPS ADVISORS INC $3.981.825 106.409 0,12% Azioni
FEDERATED HERMES, INC. $3.957.390 105.756 0,12% Azioni
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $3.834.048 105.563 0,12% Azioni
Nuveen Asset Management, LLC $3.760.151 73.541 0,12% Azioni
Burkehill Global Management, LP $3.742.000 100.000 0,12% Azioni
Nuveen, LLC $3.619.262 96.720 0,11% Azioni
VICTORY CAPITAL MANAGEMENT INC $3.484.251 93.112 0,11% Azioni
MORGAN STANLEY $3.320.829 88.744 0,10% Azioni
TWO SIGMA INVESTMENTS, LP $3.266.729 87.299 0,10% Azioni
VANGUARD ASSET MANAGEMENT, Ltd $3.254.754 86.979 0,10% Azioni
AWM Investment Company, Inc. $3.180.700 85.000 0,10% Azioni
Odyssean, LLC $3.160.344 84.456 0,10% Azioni
Affinity Asset Advisors, LLC $2.806.500 75.000 0,09% Azioni
ALGERT GLOBAL LLC $2.714.147 72.532 0,08% Azioni
ExodusPoint Capital Management, LP $2.652.404 70.882 0,08% Azioni
Ensign Peak Advisors, Inc $2.507.290 67.004 0,08% Azioni
BARCLAYS PLC $2.466.127 65.904 0,08% Azioni
FIRST TRUST ADVISORS LP $2.370.631 63.352 0,07% Azioni
Man Group plc $2.284.229 61.043 0,07% Azioni
MetLife Investment Management, LLC $2.258.709 60.361 0,07% Azioni
CITIGROUP INC $2.255.229 60.268 0,07% Azioni
Longaeva Partners L.P. $2.184.879 58.388 0,07% Azioni
Swedbank AB $2.155.392 57.600 0,07% Azioni
STATE OF WISCONSIN INVESTMENT BOARD $2.068.016 55.265 0,06% Azioni
Jump Financial, LLC $1.923.388 51.400 0,06% Azioni
Lighthouse Investment Partners, LLC $1.871.000 50.000 0,06% Azioni
Vestmark Advisory Solutions, Inc. $1.823.252 48.724 0,06% Azioni
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $1.787.254 47.762 0,06% Azioni
VANGUARD GROUP INC $1.774.626 38.123 0,06% Azioni
Point72 Asset Management, L.P. $1.735.577 46.381 0,05% Azioni
BNP PARIBAS FINANCIAL MARKETS $1.696.398 45.334 0,05% Azioni
RAYMOND JAMES FINANCIAL INC $1.606.254 42.925 0,05% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1.549.188 41.400 0,05% Opzione Call
Invesco Ltd. $1.545.446 41.300 0,05% Azioni
Vanguard Global Advisers, LLC $1.485.986 39.711 0,05% Azioni
HighMark Wealth Management LLC $1.444.224 38.595 0,04% Azioni
OAK RIDGE INVESTMENTS LLC $1.405.046 37.548 0,04% Azioni
Orion Porfolio Solutions, LLC $1.404.234 37.526 0,04% Azioni

Insider aziendali 20 insider · 9 dirigenti · 10 direttori

Insider Ruolo Ultima attività Azioni possedute Acquisti 12m Vendite 12m Netto 12m
Tobin Schilke Chief Financial Officer 10 Marzo 2025 A 52.000 0 0 $0
Marc Wilson CFO 26 Settembre 2024 M 111.092 0 0 $0
Jeff E. Knight Chief Operating Officer 19 Marzo 2025 S 87.491 0 0 $0
Stephen F. Betz Chief Scientific Officer 12 Giugno 2025 M 99.713 0 0 $0
Dana Pizzuti Chief Med and Dev Officer 19 Marzo 2025 S 72.233 0 0 $0
Isabel Kalofonos Chief Commercial Officer 10 Gennaio 2025 A 0 0 $0
James Hassard Chief Commercial Officer 05 Luglio 2024 M 29.259 0 0 $0
Alan Seth Krasner Chief Medical Officer 17 Ottobre 2023 M 43.210 0 0 $0
Ajay Madan Chief Development Officer 28 Febbraio 2022 A 176.995 0 0 $0
Coelho Rogerio Vivaldi Direttore 02 Luglio 2026 S 19.225 0 1 $-120.000
Caren Deardorf Direttore 18 Giugno 2026 A 22.225 0 0 $0
Weston Nichols Direttore 18 Giugno 2026 A 22.225 0 0 $0
Stephanie Okey Direttore 18 Giugno 2026 A 12.325 0 2 $-246.143
Matthew K Fust Direttore 18 Giugno 2026 A 28.761 0 0 $0
Camille L Bedrosian Direttore 18 Giugno 2026 A 22.225 0 0 $0
Wendell Wierenga Direttore 18 Giugno 2026 A 122.071 0 0 $0
Wendall Wierenga Direttore 11 Giugno 2025 A 116.146 0 0 $0
Stephen W Kaldor Direttore 19 Giugno 2020 A 0 0 $0
Jack Nielsen Direttore 21 Giugno 2019 A 0 0 $0
Richard Scott Struthers 07 Agosto 2026 M 424.706 0 0 $0

Insider dai depositi SEC Modulo 3/4/5; netto = solo acquisti/vendite di mercato

Attivisti e proprietari del 5%+ 1 partecipazione

Investitori che hanno depositato SEC Schedule 13D — proprietà effettiva superiore al 5% con l'intento di influenzare l'emittente (partecipazioni attiviste, campagne per il consiglio di amministrazione, M&A). Ogni riga mostra lo stato più recente noto della posizione di quel depositante.

Depositante Depositato Partecipazione Stato Scopo Deposito
Perceptive Advisors LLC, Joseph Edelman, Perceptive Life Sciences Master Fund, Ltd. ×6 depositi 01 Marzo 2024 Deposito iniziale SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Proprietà ETF Posseduti da 55 ETF

Il peso riflette solo le partecipazioni azionarie dirette (N-PORT); fondi a leva o basati su derivati possono detenere ulteriore esposizione swap non mostrata.

Fondo Peso Unità Aggiornato al Fonte
SBIO · ALPS ETF Trust 2,37% 107.892 NS 31 Maggio 2026 N-PORT
IHE · iShares Trust 1,95% 376.636 SH 08 Agosto 2026 Giornaliero
FMED · Fidelity Covington Trust 1,65% 19.000 NS 31 Maggio 2026 N-PORT
PILL · Direxion Shares ETF Trust 1,40% 4.666 NS 30 Aprile 2026 N-PORT
BBP · ETFis Series Trust I 1,23% 18.743 NS 30 Aprile 2026 N-PORT
MMSC · First Trust Exchange-Traded Fund VI… 0,75% 11.043 NS 31 Maggio 2026 N-PORT
IBB · iShares Trust 0,63% 718.323 SH 08 Agosto 2026 Giornaliero
IBBQ · Invesco Exchange-Traded Fund Trust … 0,60% 5.737 SH 08 Agosto 2026 Giornaliero
IWO · iShares Trust 0,54% 940.202 SH 08 Agosto 2026 Giornaliero
NUSC · Nushares ETF Trust 0,28% 93.045 NS 30 Aprile 2026 N-PORT
ISCG · iShares Trust 0,27% 32.694 SH 08 Agosto 2026 Giornaliero
IWM · iShares Trust 0,27% 2.625.192 SH 08 Agosto 2026 Giornaliero
VTWG · VANGUARD SCOTTSDALE FUNDS 0,23% 110.770 SH 08 Agosto 2026 Giornaliero
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0,20% 38.553 NS 30 Aprile 2026 N-PORT
BIB · ProShares Trust 0,19% 3.872 NS 31 Maggio 2026 N-PORT
ESML · iShares Trust 0,16% 55.438 SH 08 Agosto 2026 Giornaliero
BKSE · BNY Mellon ETF Trust 0,15% 3.142 NS 30 Aprile 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0,15% 51.135 SH 08 Agosto 2026 Giornaliero
FNY · First Trust Exchange-Traded AlphaDE… 0,14% 18.879 NS 30 Aprile 2026 N-PORT
ISCB · iShares Trust 0,13% 4.625 SH 08 Agosto 2026 Giornaliero
VTWO · VANGUARD SCOTTSDALE FUNDS 0,12% 596.648 SH 08 Agosto 2026 Giornaliero
RSSL · Global X Funds 0,12% 42.391 NS 30 Aprile 2026 N-PORT
VBK · VANGUARD INDEX FUNDS 0,11% 1.399.667 SH 08 Agosto 2026 Giornaliero
FFSM · FIDELITY COVINGTON TRUST 0,10% 31.759 NS 30 Aprile 2026 N-PORT
ITWO · ProShares Trust 0,09% 4.601 NS 31 Maggio 2026 N-PORT
OMFS · Invesco Exchange-Traded Self-Indexe… 0,09% 2.909 SH 08 Agosto 2026 Giornaliero
SCHA · SCHWAB STRATEGIC TRUST 0,08% 492.431 NS 31 Maggio 2026 N-PORT
FNX · First Trust Exchange-Traded AlphaDE… 0,07% 24.991 NS 30 Aprile 2026 N-PORT
WSML · iShares Trust 0,07% 5.742 SH 08 Agosto 2026 Giornaliero
FHLC · FIDELITY COVINGTON TRUST 0,06% 41.183 NS 30 Aprile 2026 N-PORT
DFAS · Dimensional ETF Trust 0,05% 196.549 NS 30 Aprile 2026 N-PORT
UWM · ProShares Trust 0,05% 3.599 NS 31 Maggio 2026 N-PORT
VB · VANGUARD INDEX FUNDS 0,05% 2.419.186 SH 08 Agosto 2026 Giornaliero
VHT · VANGUARD WORLD FUND 0,05% 275.155 SH 08 Agosto 2026 Giornaliero
FAD · First Trust Exchange-Traded AlphaDE… 0,04% 5.196 NS 30 Aprile 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0,04% 1.210.574 SH 08 Agosto 2026 Giornaliero
AVIE · AMERICAN CENTURY ETF TRUST 0,04% 112 NS 31 Maggio 2026 N-PORT
URTY · ProShares Trust 0,04% 3.643 NS 31 Maggio 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0,02% 5.689 NS 31 Maggio 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0,02% 3.773 NS 31 Maggio 2026 N-PORT
HDG · ProShares Trust 0,02% 91 NS 31 Maggio 2026 N-PORT
ITOT · iShares Trust 0,01% 146.419 SH 08 Agosto 2026 Giornaliero
IWV · iShares Trust 0,01% 27.043 SH 08 Agosto 2026 Giornaliero
DFAC · Dimensional ETF Trust 0,01% 125.853 NS 30 Aprile 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0,01% 3.342.704 SH 08 Agosto 2026 Giornaliero
VTHR · VANGUARD SCOTTSDALE FUNDS 0,01% 8.345 SH 08 Agosto 2026 Giornaliero
ESGV · VANGUARD WORLD FUND 0,01% 22.843 SH 08 Agosto 2026 Giornaliero
ONEQ · Fidelity Commonwealth Trust 0,01% 28.694 NS 31 Maggio 2026 N-PORT
DCOR · Dimensional ETF Trust 0,01% 5.863 NS 30 Aprile 2026 N-PORT
TILT · FlexShares Trust 0,01% 3.388 NS 30 Aprile 2026 N-PORT